301. Individualised risk in patients undergoing lung volume reduction surgery: the Glenfield BFG score.
- Author
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Greening NJ, Vaughan P, Oey I, Steiner MC, Morgan MD, Rathinam S, and Waller DA
- Subjects
- Aged, Area Under Curve, Body Mass Index, Carbon Monoxide chemistry, Decision Making, Female, Forced Expiratory Volume, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Plethysmography, Prospective Studies, Pulmonary Disease, Chronic Obstructive mortality, Pulmonary Disease, Chronic Obstructive physiopathology, Pulmonary Disease, Chronic Obstructive surgery, ROC Curve, Regression Analysis, Risk, Sensitivity and Specificity, Time Factors, Lung physiopathology, Lung surgery, Pneumonectomy methods, Severity of Illness Index
- Abstract
Lung volume reduction surgery (LVRS) has been shown to be beneficial in patients with chronic obstructive pulmonary disease, but there is low uptake, partly due to perceived concerns of high operative mortality. We aimed to develop an individualised risk score following LVRS.This was a cohort study of patients undergoing LVRS. Factors independently predicting 90-day mortality and a risk prediction score were identified. Reliability of the score was tested using area under the receiver operating characteristic curve (AUROC).237 LVRS procedures were performed. The multivariate analysis factors associated independently with death were: body mass index (BMI)<18.5 kg·m
-2 (OR 2.83, p=0.059), forced expiratory volume in 1 s (FEV1 )<0.71 L (OR 5.47, p=0.011) and transfer factor of the lung for carbon monoxide ( TLCO ) <20% (OR 5.56, p=0.031). A risk score was calculated and total score assigned. AUROC for the risk score was 0.80 and a better predictor than individual components (p<0.01). The score was stratified into three risk groups. Of the total patients, 46% were classified as low risk. Similar improvements in lung function and health status were seen in all groups. The score was introduced and tested in a further 71 patients. AUROC for 90-day mortality in this cohort was 0.84.It is possible to provide an individualised predictive risk score for LVRS, which may aid decision making for both clinicians and patients., Competing Interests: Conflict of interest: Disclosures can be found alongside this article at erj.ersjournals.com, (Copyright ©ERS 2017.)- Published
- 2017
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