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Once awarded Archie Cochrane's infamous 'wooden spoon' for the limited application of randomised controlled trial evidence to questions of clinical practice, obstetricians were inspired to action and ultimately became leaders in the development of evidence based medicine.(1) This article is protected by copyright. All rights reserved.

Asteroseismology of bright stars has become increasingly important as a method to determine fundamental properties (in particular ages) of stars. The Kepler Space Telescope initiated a revolution by detecting oscillations in more than 500 main-sequence and subgiant stars. However, most Kepler stars are faint, and therefore have limited constraints from independent methods such as long-baseline interferometry. Here, we present the discovery of solar-like oscillations in $��$ Men A, a naked-eye (V=5.1) G7 dwarf in TESS's Southern Continuous Viewing Zone. Using a combination of astrometry, spectroscopy, and asteroseismology, we precisely characterize the solar analog alpha Men A (Teff = 5569 +/- 62 K, R = 0.960 +/- 0.016 Rsun, M = 0.964 +/- 0.045 Msun). To characterize the fully convective M dwarf companion, we derive empirical relations to estimate mass, radius, and temperature given the absolute Gaia magnitude and metallicity, yielding M = 0.169 +/- 0.006, R = 0.19 +/- 0.01 and Teff = 3054 +/- 44 K. Our asteroseismic age of 6.2 +/- 1.4 (stat) +/- 0.6 (sys) Gyr for the primary places $��$ Men B within a small population of M dwarfs with precisely measured ages. We combined multiple ground-based spectroscopy surveys to reveal an activity cycle of 13.1 +/- 1.1 years, a period similar to that observed in the Sun. We used different gyrochronology models with the asteroseismic age to estimate a rotation period of ~30 days for the primary. Alpha Men A is now the closest (d=10pc) solar analog with a precise asteroseismic age from space-based photometry, making it a prime target for next-generation direct imaging missions searching for true Earth analogs., Accepted to The Astrophysical Journal; 15 pages, 10 figures

OBJECTIVE: Selective fetal growth restriction (sFGR) occurs in monochorionic twin pregnancies when unequal placental sharing leads to restriction in the growth of just one twin. Management options include laser separation of the fetal circulations, selective reduction or expectant management, but what constitutes the best treatment is not yet known. New trials in this area are urgently needed but, in this rare and complex group, maximizing the relevance and utility of clinical research design and outputs is paramount. A core outcome set ensures standardized outcome collection and reporting in future research. The objective of this study was to develop a core outcome set for studies evaluating treatments for sFGR in monochorionic twins. METHODS: An international steering group of clinicians, researchers and patients with experience of sFGR was established to oversee the process of development of a core outcome set for studies investigating the management of sFGR. Outcomes reported in the literature were identified through a systematic review and informed the design of a three-round Delphi survey. Clinicians, researchers, and patients and family representatives participated in the survey. Outcomes were scored on a Likert scale from 1 (limited importance for making a decision) to 9 (critical for making a decision). Consensus was defined a priori as a Likert score of ≥ 8 in the third round of the Delphi survey. Participants were then invited to take part in an international meeting of stakeholders in which the modified nominal group technique was used to consider the consensus outcomes and agree on a final core outcome set. RESULTS: Ninety-six outcomes were identified from 39 studies in the systematic review. One hundred and three participants from 23 countries completed the first round of the Delphi survey, of whom 88 completed all three rounds. Twenty-nine outcomes met the a priori criteria for consensus and, along with six additional outcomes, were prioritized in a consensus development meeting, using the modified nominal group technique. Twenty-five stakeholders participated in this meeting, including researchers (n = 3), fetal medicine specialists (n = 3), obstetricians (n = 2), neonatologists (n = 3), midwives (n = 4), parents and family members (n = 6), patient group representatives (n = 3), and a sonographer. Eleven core outcomes were agreed upon. These were live birth, gestational age at birth, birth weight, intertwin birth-weight discordance, death of surviving twin after death of cotwin, loss during pregnancy or before final hospital discharge, parental stress, procedure-related adverse maternal outcome, length of neonatal stay in hospital, neurological abnormality on postnatal imaging and childhood disability. CONCLUSIONS: This core outcome set for studies investigating the management of sFGR represents the consensus of a large and diverse group of international collaborators. Use of these outcomes in future trials should help to increase the clinical relevance of research on this condition. Consensus agreement on core outcome definitions and measures is now required. Copyright © 2019 ISUOG. Published by John Wiley & Sons Ltd. ispartof: ULTRASOUND IN OBSTETRICS & GYNECOLOGY vol:55 issue:5 pages:652-660 ispartof: location:England status: published