332 results on '"Tondera A"'
Search Results
302. Corrigendum to "Constructed wetlands for combined seweroverflow treatment: A state-of-the-art review"[Sci. Total Environ. 727 (2020) 138618].
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Rizzo, A., Tondera, K., Pálfy, T.G., Dittmer, U., Meyer, D., Schreiber, C., Zacharias, N., Ruppelt, J.P., Esser, D., Molle, P., Troesch, S., and Masi, F.
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- 2021
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303. Metabolic Signatures Uncover Distinct Targets in Molecular Subsets of Diffuse Large B Cell Lymphoma
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Erik Norberg, Bjoern Chapuy, Michael R. Green, Jarrod A. Marto, Hong Yin, Stefano Monti, Linfeng Chen, Feng Zhou, Klaudia Polak, Pilar Caro, Daniel Tondera, Illana A. Stanley, Scott B. Ficarro, Margaret A. Shipp, John S. Gounarides, Nika N. Danial, and Amar U. Kishan
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Cancer Research ,B-cell receptor ,breakpoint cluster region ,Cell Biology ,Biology ,Mitochondrion ,medicine.disease ,Article ,Cell biology ,Biochemistry ,Oncology ,hemic and lymphatic diseases ,Proteome ,medicine ,Receptor ,Beta oxidation ,Gene ,Diffuse large B-cell lymphoma - Abstract
SummaryMolecular signatures have identified several subsets of diffuse large B cell lymphoma (DLBCL) and rational targets within the B cell receptor (BCR) signaling axis. The OxPhos-DLBCL subset, which harbors the signature of genes involved in mitochondrial metabolism, is insensitive to inhibition of BCR survival signaling but is functionally undefined. We show that, compared with BCR-DLBCLs, OxPhos-DLBCLs display enhanced mitochondrial energy transduction, greater incorporation of nutrient-derived carbons into the tricarboxylic acid cycle, and increased glutathione levels. Moreover, perturbation of the fatty acid oxidation program and glutathione synthesis proved selectively toxic to this tumor subset. Our analysis provides evidence for distinct metabolic fingerprints and associated survival mechanisms in DLBCL and may have therapeutic implications.
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304. Assessing the role of microbial communities in the performance of constructed wetlands used to treat combined sewer overflows.
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Ruppelt, Jan P., Tondera, Katharina, Wallace, Sarah J., Button, Mark, Pinnekamp, Johannes, and Weber, Kela P.
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Combined sewer overflows are contaminated with various micropollutants which pose risk to both environmental and human health. Some micropollutants, such as carbamazepine and sulfamethoxazole, are very persistent and difficult to remove from wastewater. Event loaded vertical-flow constructed wetlands (retention soil filters; RSFs) have proven to be effective in the treatment of combined sewer overflows for a wide range of pollutants. However, little is known about how microbial communities contribute to the treatment efficiency, specifically to the reduction of micropollutants. To the best of our knowledge, this is the first study attempting to close this gap. Microbial communities in pilot-scale RSFs were investigated, which showed explicit grouping of metabolic activity at different filter depths with some differential abundance of identified genera. The highest microbial activity was found in the top layer of 0.75 m deep filters, whereas homogeneous activity dominated in a 0.50 m deep filter, indicating oxygen availability to be a limiting factor of the metabolic activity in RSFs. The removal efficiencies of all investigated organic trace substances were correlated to the utilization of specific carbon sources. Most notable is the correlation between the carbon source glucose-1-phosphate and the removal of metoprolol. The strongest correlations for other substances were the removal of diclofenac to the utilization of the carbohydrate i-erythritole; bisphenol A to carbohydrate α- d -lactose, and 1-H-benzotriazole to carbonic acid D-galacturonic acid. Those results are supported by positive correlations of specific microbial genera with both the utilization of the above mentioned carbon sources and the removal efficiency for the respective micropollutants. Most notable is correlation of Tetrasphaera and the removal of benzotriazole and diclofenac. Unlabelled Image • Insights to removal mechanisms of constructed wetlands for combined sewer overflows • Microbial function and structure were analyzed within the same systems. • Grouping of the metabolic acitivity at different filter depths was identified. • Specific carbon sources found as co-metabolites for the removal of micropollutants. • Interrelations of microbial genera, utilization of carbon sources and performance [ABSTRACT FROM AUTHOR]
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- 2020
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305. Effect of Plant Species and Nutrient Loading Rates in Treatment Wetlands for Polluted River Water Under a Subtropical Climate.
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Tondera, Katharina, Shang, Kankan, Vincent, Gilles, Chazarenc, Florent, Hu, Yonghong, and Brisson, Jacques
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TYPHA latifolia ,PLANT nutrients ,PHRAGMITES ,GIANT reed ,PLANT species ,WETLANDS ,ADVECTION ,WETLAND restoration - Abstract
The performance of 14 large pilot-scale horizontal flow wetlands (~ 60 m
2 each) designed to treat polluted river water was tested in a 3-year study at the Chenshan Botanical Garden in Shanghai, China. Five local species, Arundo donax, Cyperus alternifolius, Phragmites australis, Thalia dealbata and Typha orientalis, were planted in monocultures and in a polyculture of Phragmites, Thalia and Typha. Total nitrogen (TN) removal was compared among species and to an unplanted bed. Each bed was replicated once, and the parallel setup received a TN inflow concentration of 16 mg L−1 on average over each summer season, a level twice as high as for the beds receiving unspiked inflow. During the first 2 years of operation, the only significant differences in pollutant removal were between planted and unplanted systems. In the third year, significant differences appeared among planted beds in the high nutrient systems, with Phragmites being the most efficient species in TN removal and Arundo the least, suggesting that greater inflow and more maturity may be needed before differences can be detected. The polyculture was never significantly more efficient than the other planted systems. However, it ranked among the best systems in 2018. Yet, while a greater removal of the polyculture over the average TN removal of all monocultures taken together may develop over time, we found no evidence that the polyculture may get more efficient than the best monoculture. Observation over all phases of plant establishment made it possible to draw conclusions for future design and operation. [ABSTRACT FROM AUTHOR]- Published
- 2020
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306. Constructed wetlands for combined sewer overflow treatment: A state-of-the-art review.
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Rizzo, A., Tondera, K., Pálfy, T.G., Dittmer, U., Meyer, D., Schreiber, C., Zacharias, N., Ruppelt, J.P., Esser, D., Molle, P., Troesch, S., and Masi, F.
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Combined sewer overflows (CSOs) are a major source of surface water pollution and degradation. This is particularly visible where sewage collection with combined sewer and centralized treatment are well established, such as in Europe and North America: an overwhelming number of surface water bodies are in insufficient status of ecology, hydrology and physico-chemical parameters. Therefore, several countries have started implementing constructed wetlands (CWs) as mainstream on-spot treatment. This paper summarizes the main design approaches that can be adopted. We identified eight different schemes for the implementation of CSO-CWs, based on our international experience and documented by a literature analysis. The performance review includes conventional water quality parameters, as well as pathogen and emergent contaminant removal. Furthermore, modelling tools for advanced design and for understanding a wide applicability of these green infrastructures are presented. This paper also provides a review on other side benefits offered by the adoption of Nature-Based Solutions for CSO treatment, such as ecosystem services, and the most common issues related to their operation and maintenance. Our analysis has produced a list of key factors for design and operation, all derived from full-scale installations in operation up to more than ten years. Unlabelled Image • Combined sewer overflows (CSOs) convey significant pollutant loads to water bodies. • Constructed wetlands (CWs) are Nature-Based Solutions for CSO pollution control. • Review gives state-of-the-art of CSO-CWs based on research and year-long practice. • CSO-CWs show effective removal of conventional, emerging and pathogenic pollutants. • CSO-CWs can provide other ecosystem services (e.g. flood protection, biodiversity). [ABSTRACT FROM AUTHOR]
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- 2020
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307. Generation of three induced pluripotent cell lines (iPSCs) from an Aicardi–Goutières syndrome (AGS) patient harboring a deletion in the genomic locus of the sterile alpha motif and HD domain containing protein 1 (SAMHD1).
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Fuchs, Nina V., Schieck, Maximilian, Neuenkirch, Michaela, Tondera, Christiane, Schmitz, Heike, Wendeburg, Lena, Steinemann, Doris, Elpers, Christiane, Rutsch, Frank, and König, Renate
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Aicardi-Goutières syndrome (AGS) is a hereditary early onset encephalopathy. AGS patients display variable clinical manifestations including intracranial calcification, cerebral atrophy, white matter abnormalities and characteristic leukocytosis as well as a constitutive upregulation of type I IFN production indicative of a type I interferonopathy. Seven genes (SAMHD1, TREX1, RNASEH2B, RNASEH2C, RNASEH2A, ADAR1, IFIH1) have been associated with the AGS phenotype, up to now. Here, we describe the generation of three induced pluripotent stem cell lines from a patient with a deletion of coding exons 14 and 15 of the SAMHD1 gene. [ABSTRACT FROM AUTHOR]
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- 2020
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308. Induced pluripotent stem cell line (PEIi003-A) derived from an apparently healthy male individual.
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Fuchs, Nina V., Schieck, Maximilian, Neuenkirch, Michaela, Tondera, Christiane, Schmitz, Heike, Steinemann, Doris, Göhring, Gudrun, and König, Renate
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Induced pluripotent stem cells (iPSCs) are a useful tool to investigate pathomechanistic and cellular processes due to their differentiation potential into different somatic cell types in vitro. Here, we have generated iPSCs from an apparently healthy male individual using an integration-free reprogramming method. The resulting iPSCs are pluripotent and display a normal karyotype. Furthermore, we demonstrate that this iPSC line can be differentiated into all three germ layers. [ABSTRACT FROM AUTHOR]
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- 2020
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309. Induced pluripotent stem cells (iPSCs) derived from a renpenning syndrome patient with c.459_462delAGAG mutation in PQBP1 (PEIi001-A).
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Fuchs, Nina V., Schieck, Maximilian, Neuenkirch, Michaela, Tondera, Christiane, Schmitz, Heike, des Portes, Vincent, Germanaud, David, Steinemann, Doris, Göhring, Gudrun, and König, Renate
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The Renpenning syndrome spectrum is a rare X-linked mental retardation syndrome characterized by intellectual disability, microcephaly, low stature, lean body and hypogonadism. Mutations in the polyglutamine tract binding protein 1 (PQBP1) locus are causative for disease. Here, we describe the generation of an iPSC line from a patient mutated in the polar amino acid-rich domain of PQBP1 resulting in a C-terminal truncated protein (c.459_462 delAGAG, type p.R153fs193X). [ABSTRACT FROM AUTHOR]
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- 2019
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310. Combined sewer overflows: A critical review on best practice and innovative solutions to mitigate impacts on environment and human health.
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Botturi, Alice, Ozbayram, E. Gozde, Tondera, Katharina, Gilbert, Nathalie I., Rouault, Pascale, Caradot, Nicolas, Gutierrez, Oriol, Daneshgar, Saba, Frison, Nicola, Akyol, Çağrı, Foglia, Alessia, Eusebi, Anna Laura, and Fatone, Francesco
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COMBINED sewer overflows , *SEWERAGE , *BEST practices - Abstract
Combined sewer overflows (CSOs) are of major environmental concern for impacted surface waterbodies. In the last decades, major storm events have become increasingly regular in some areas, and meteorological scenarios predict a further rise in their frequency. Consequently, control and treatment of CSOs with respect to best practice examples, innovative treatment solutions, and management of sewer systems are an inevitable necessity. As a result, the number of publications concerning quality, quantity, and type of treatments has recently increased. This review therefore aims to provide a critical overview on the effects, control, and treatment of CSOs in terms of impact on the environment and public health, strict measures addressed by regulations, and the various treatment alternatives including natural and compact treatments. Drawing together the previous studies, an innovative treatment and control guideline are also proposed for the better management practices. [ABSTRACT FROM AUTHOR]
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- 2021
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311. Improving Flows in Misaligned Culverts.
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Jaeger, Rick, Jacobs, Carolyn, Tondera, Katharina, and Tindale, Neil
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CULVERTS ,COMPUTATIONAL fluid dynamics ,CONSTRUCTION costs ,HIGHER order transitions - Abstract
This study investigated different approaches to optimize flows in misaligned culverts. Structures aligned with the natural stream are always preferred, as misalignments cause a change of direction at the culvert inlet associated with lower performance and sedimentation and erosion problems. This optimal positioning can cause high financial costs and a flow optimization minimizing the associated problems could be a viable alternative. In this study, we used computational fluid dynamics analysis to evaluate the flow in 44 different scenarios with misalignment angles ranging from 0 ° to 90 °. It was found that smooth transitions towards the narrowest point in the stream (culvert) were possible for any degree of misalignment resulting in improved, uniform velocity distributions and less turbulence. An experimental setup was able to confirm the possible flow improvements. The proposed approach of flow redirection can lower construction costs and gives planners and designers more flexibility as tailored reinforcement and redesign of the stream embankment can be used as an alternative to costly creek alignments. [ABSTRACT FROM AUTHOR]
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- 2019
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312. Combined Sewer Overflows: A critical review on best practice and innovative solutions to mitigate impacts on environment and human health
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Alice Botturi, E. Gozde Ozbayram, Katharina Tondera, Nathalie I. Gilbert, Pascale Rouault, Nicolas Caradot, Oriol Gutierrez, Saba Daneshgar, Nicola Frison, Çağrı Akyol, Alessia Foglia, Anna Laura Eusebi, and Francesco Fatone
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Combined sewer overflows ,13. Climate action ,nature based solutions ,urban water management ,water quality ,6. Clean water ,3. Good health ,sewer system - Abstract
Combined sewer overflows (CSOs) are of major environmental concern for impacted surface waterbodies. In the last decades, major storm events have become increasingly regular in someareas, and meteorological scenarios predict a further rise in their frequency. Consequently, control and treatment of CSOs with respect to best practice examples, innovative treatment solutions and management of sewer systems is an inevitable necessity. As a result, the number ofpublications concerning quality, quantity and type of treatments has recently increased. This review therefore aims to provide a critical overview on the effects, control and treatment of CSOs in terms of impact on the environment and public health, strict measures addressed byregulations, and the various treatment alternatives including natural and compact treatments. Drawing together the previous studies, an innovative treatment and control guideline is also proposed for the better management practices.
313. Homeostatic functions of BCL-2 proteins beyond apoptosis
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Danial, Nn, Alfredo Giménez-Cassina, and Tondera, D.
314. Proceedings of the Frontiers of Retrovirology Conference 2016
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Irena Zurnic, Sylvia Hütter, Ute Lehmann, Nicole Stanke, Juliane Reh, Tobias Kern, Fabian Lindel, Gesche Gerresheim, Martin Hamann, Erik Müllers, Paul Lesbats, Peter Cherepanov, Erik Serrao, Alan Engelman, Dirk Lindemann, Claire Da Silva Santos, Kevin Tartour, Andrea Cimarelli, Rya Burdick, Jianbo Chen, Jaya Sastri, Wei-Shau Hu, Vinay Pathak, Oliver T. Keppler, Karine Pradeau, Sylvia Eiler, Nicolas Levy, Sarah Lennon, Sarah Cianferani, Stéphane Emiliani, Marc Ruff, Vincent Parissi, Sylvie Rato, Antonio Rausell, Miguel Munoz, Amalio Telenti, Angela Ciuffi, Alexander Zhyvoloup, Anat Melamed, Ian Anderson, Delphine Planas, Janos Kriston-Vizi, Robin Ketteler, Chen- Hsuin Lee, Andy Merritt, Petronela Ancuta, Charles Bangham, Ariberto Fassati, Anthony Rodari, Benoit Van Driessche, Mathilde Galais, Nadége Delacourt, Sylvain Fauquenoy, Caroline Vanhulle, Anna Kula, Arsène Burny, Olivier Rohr, Carine Van Lint, Thijs van Montfort, Renee van der Sluis, Dave Speijer, Ben Berkhout, Bo Meng, Andrzej Rutkowski, Neil Berry, Lars Dölken, Andrew Lever, Thomas Schuster, Benedikt Asbach, Ralf Wagner, Christine Gross, Veit Wiesmann, Martina Kalmer, Thomas Wittenberg, Jan Gettemans, Andrea K. Thoma-Kress, Minghua Li, Eric O. Freed, Shan-Lu Liu, Janis Müller, Jan Münch, Xaver Sewald, Pradeep Uchil, Mark Ladinsky, Jagadish Beloor, Ruoxi Pi, Christin Herrmann, Nasim Motamedi, Thomas Murooka, Michael Brehm, Dale Greiner, Thorsten Mempel, Pamela Bjorkman, Priti Kumar, Walther Mothes, Simone Joas, Erica Parrish, Clement Wesley Gnanadurai, Edina Lump, Christina M. Stürzel, Nicholas F. Parrish, Ulrike Sauermann, Katharina Töpfer, Tina Schultheiss, Steven Bosinger, Guido Silvestri, Cristian Apetrei, Nicholas Huot, Michaela Müller-Trutwin, Daniel Sauter, Beatrice H. Hahn, Christiane Stahl-Hennig, Frank Kirchhoff, Gerald Schumann, Sabine Jung-Klawitter, Nina V. Fuchs, Kyle R. Upton, Martin Muñoz-Lopez, Ruchi Shukla, Jichang Wang, Marta Garcia-Canadas, Cesar Lopez-Ruiz, Daniel J. Gerhardt, Attila Sebe, Ivana Grabundzija, Patricia Gerdes, Sylvia Merkert, Andres Pulgarin, Anja Bock, Ulrike Held, Anett Witthuhn, Alexandra Haase, Ernst J. Wolvetang, Ulrich Martin, Zoltán Ivics, Zsuzsanna Izsvák, J. Garcia-Perez, Geoffrey J. Faulkner, Tara Hurst, Aris Katzourakis, Gkikas Magiorkinis, Kerstin Schott, Rita Derua, Janna Seifried, Andreas Reuter, Heike Schmitz, Christiane Tondera, Alberto Brandariz-Nuñez, Felipe Diaz-Griffero, Veerle Janssens, Renate König, Hanna-Mari Baldauf, Lena Stegmann, Sarah-Marie Schwarz, Maud Trotard, Margarethe Martin, Gina Lenzi, Manja Burggraf, Xiaoyu Pan, Oliver I. Fregoso, Efrem S. Lim, Libin Abraham, Elina Erikson, Laura Nguyen, Ina Ambiel, Frank Rutsch, Baek Kim, Michael Emerman, Oliver T. Fackler, Sabine Wittmann, Rayk Behrendt, Bianca Volkmann, Kristin Eissmann, Thomas Gramberg, Sebastian Bolduan, Herwig Koppensteiner, Stefanie Regensburg, Ruth Brack-Werner, Rika Draenert, Michael Schindler, Aurélie Ducroux, Shuting Xu, Aparna Ponnurangam, Sergej Franz, Angelina Malassa, Ellen Ewald, Christine Goffinet, Sin-Yee Fung, Ching-Ping Chan, Chun-Kit Yuen, Kin-Hang Kok, Chin-Ping Chan, Dong-Yan Jin, Ulf Dittmer, Dorota Kmiec, Shilpa Iyer, Christina Stürzel, Beatrice Hahn, Yasuo Ariumi, Mariko Yasuda-Inoue, Koudai Kawano, Satoshi Tateishi, Priscilla Turelli, Alex Compton, Nicolas Roy, Françoise Porrot, Anne Billet, Nicoletta Casartelli, Jacob Yount, Chen Liang, Oliver Schwartz, Carsten Magnus, Lucia Reh, Penny Moore, Therese Uhr, Jacqueline Weber, Lynn Morris, Alexandra Trkola, Rashel V. Grindberg, Erika Schlaepfer, Gideon Schreiber, Viviana Simon, Roberto F. Speck, Zeger Debyser, Lenard Vranckx, Jonas Demeulemeester, Suha Saleh, Eric Verdin, Anna Cereseto, Frauke Christ, Rik Gijsbers, Gang Wang, Na Zhao, Atze T. Das, Josef Köstler, Beatriz Perdiguero, Mariano Esteban, Bertram L. Jacobs, David C. Montefiori, Celia C. LaBranche, Nicole L. Yates, Georgia D. Tomaras, Guido Ferrari, Kathryn E. Foulds, Mario Roederer, Gary Landucci, Donald N. Forthal, Michael S. Seaman, Natalie Hawkins, Steven G. Self, Sanjay Phogat, James Tartaglia, Susan W. Barnett, Brian Burke, Anthony D. Cristillo, Song Ding, Jonathan L. Heeney, Giuseppe Pantaleo, Viktoria Stab, Armin Ensser, Bettina Tippler, Dennis Burton, Matthias Tenbusch, Klaus Überla, Galit Alter, Giuseppe Lofano, Anne-Sophie Dugast, Viraj Kulkarni, Todd Suscovich, Tatiana Opazo, Felipe Barraza, Diego Herrera, Andrea Garces, Tomas Schwenke, Diego Tapia, Jorge Cancino, Gloria Arriagada, Christina Haußner, Dominik Damm, Anette Rohrhofer, Barbara Schmidt, Jutta Eichler, Rebecca Midgley, James Wheeldon, Vincent Piguet, Priyanka Khopkar, Megha Rohamare, Smita Kulkarni, Ana Godinho-Santos, Allan Hance, Joao Goncalves, Fabrizio Mammano, Romain Gasser, Meriem Hamoudi, Martina Pellicciotta, Zhicheng Zhou, Clara Visdeloup, Philippe Colin, Martine Braibant, Bernard Lagane, Matteo Negroni, Jula Wamara, Norbert Bannert, Thibault Mesplede, Nathan Osman, Kaitlin Anstett, Jiaming Calvin Liang, Hanh Thi Pham, Mark Wainberg, Wei Shao, Jigui Shan, Mary Kearney, Xiaolin Wu, Frank Maldarelli, John Mellors, Brian Luke, John Coffin, Stephen Hughes, Thomas Fricke, Silvana Opp, Caitlin Shepard, Dmitri Ivanov, Jose Valle-Casuso, Marine Kanja, Pierre Cappy, Daniela Lener, Ekaterina Knyazhanskaya, Andrey Anisenko, Timofey Zatsepin, Marina Gottikh, Alexander Komkov, Anastasia Minervina, Gaiaz Nugmanov, Vadim Nazarov, Konstantin Khodosevich, Ilgar Mamedov, Yuri Lebedev, Marta Colomer-Lluch, Ruth Serra-Moreno, Ambra Sarracino, Lavina Gharu, Alexander Pasternak, Alessandro Marcello, Ann Marie McCartin, Anurag Kulkarni, Valentin Le Douce, Virginie Gautier, Ann Baeyens, Evelien Naessens, Anouk Van Nuffel, Karin Weening, Anne- Marie Reilly, Eva Claeys, Wim Trypsteen, Linos Vandekerckhove, Sven Eyckerman, Kris Gevaert, Bruno Verhasselt, Hoi Ping Mok, Nicholas Norton, Axel Fun, Jack Hirst, Mark Wills, Dalibor Miklik, Filip Senigl, Jiri Hejnar, Jun-ichi Sakuragi, Sayuri Sakuragi, Masaru Yokoyama, Tatsuo Shioda, Hironori Sato, Jochen Bodem, Rebecca Moschall, Sarah Denk, Steffen Erkelenz, Christian Schenk, Heiner Schaal, Norbert Donhauser, Ellen Socher, Sebastian Millen, Heinrich Sticht, Melanie Mann, Guochao Wei, Matthew J. Betts, Yang Liu, Timo Kehl, Robert B. Russell, Martin Löchelt, Oliver Hohn, Saeed Mostafa, Kirsten Hanke, Stephen Norley, Chia-Yen Chen, Masashi Shingai, Pedro Borrego, Nuno Taveira, Klaus Strebel, Chris Hellmund, Melanie Friedrich, Friedrich Hahn, Christian Setz, Pia Rauch, Kirsten Fraedrich, Alina Matthaei, Petra Henklein, Maximilian Traxdorf, Torgils Fossen, Ulrich Schubert, Aya Khwaja, Meytal Galilee, Akram Alian, Birco Schwalbe, Heiko Hauser, Michael Schreiber, Mirte Scherpenisse, Young-Keol Cho, Jungeun Kim, Daeun Jeong, Katerina Trejbalova, Martina Benesova, Dana Kucerova, Zdenka Vernerova, Rachel Amouroux, Petra Hajkova, Daniel Elleder, Tomas Hron, Helena Farkasova, Abinash Padhi, Jan Paces, Henan Zhu, Robert Gifford, Pablo Murcia, Maria Luisa Carrozza, Anna-Maria Niewiadomska, Maurizio Mazzei, Mounir Abi-Said, Joseph Hughes, Stéphane Hué, Adetayo Obasa, Graeme Jacobs, Susan Engelbrecht, Katharina Mack, Kathrin Starz, Matthias Geyer, Frederic Bibollet-Ruche, Marie Leoz, Jean Christophe Plantier, Ayele Argaw-Denboba, Emanuela Balestrieri, Annalucia Serafino, Ilaria Bucci, Chiara Cipriani, Corrado Spadafora, Paolo Sinibaldi-Vallebona, Claudia Matteucci, S. Nandi Jayashree, Ujjwal Neogi, Anil K. Chhangani, Shravan Sing Rathore, Bajrang R. J. Mathur, Adeyemi Abati, B. Taylan Koç, Tuba Çiğdem Oğuzoğlu, Takatoshi Shimauchi, Stephan Caucheteux, Jocelyn Turpin, Katja Finsterbusch, Yoshiki Tokura, Shanti Souriant, Luciana Balboa, Karine Pingris, Denise Kviatcowsky, Brigitte Raynaud-Messina, Céline Cougoule, Ingrid Mercier, Marcelo Kuroda, Pablo González-Montaner, Sandra Inwentarz, Eduardo Jose Moraña, Maria del Carmen Sasiain, Olivier Neyrolles, Isabelle Maridonneau-Parini, Geanncarlo Lugo-Villarino, Christel Vérollet, Alexandra Herrmann, Dominique Thomas, Nerea Ferreirós Bouzas, Xavier Lahaye, Anvita Bhargava, Takeshi Satoh, Matteo Gentili, Silvia Cerboni, Aymeric Silvin, Cécile Conrad, Hakim Ahmed-Belkacem, Elisa C. Rodriguez, Jean-François Guichou, Nathalie Bosquet, Matthieu Piel, Roger Le Grand, Megan King, Jean-Michel Pawlotsky, Nicolas Manel, Henning Hofmann, Benedicte Vanwalscappel, Nicolin Bloch, Nathaniel Landau, Stanislav Indik, Benedikt Hagen, José Carlos Valle-Casuso, Awatef Allouch, Annie David, Françoise Barré-Sinoussi, Monsef Benkirane, Gianfranco Pancino, Asier Saez-Cirion, Wing-Yiu Lee, Richard Sloan, Bianca Schulte, Jonas Blomberg, Luana Vargiu, Patricia Rodriguez-Tomé, Enzo Tramontano, Göran Sperber, Namita Kumari, Tatiana Ammosova, Sharmeen Diaz, Patricia Oneal, Sergei Nekhai, Audrey Fahrny, Gustavo Gers-Huber, Annette Audigé, Anitha Jayaprakash, Ravi Sachidanandam, Matt Hernandez, Marsha Dillon-White, Emmanuel Maze, Claire Ham, Neil Almond, Greg Towers, Robert Belshaw, Patrícia de Sousa-Pereira, Joana Abrantes, Massimo Pizzato, Pedro J. Esteves, Tanja Kahle, Sven Schmitt, Laura Merkel, Nina Reuter, Thomas Stamminger, Ilaria Dalla Rosa, Kate Bishop, Antonella Spinazzola, Harriet Groom, Gabrielle Vieyres, Mathias Müsken, Thomas Zillinger, Veit Hornung, Winfried Barchet, Susanne Häussler, Thomas Pietschmann, Aneela Javed, Nicole Leuchte, Gabriela Salinas, Lennart Opitz, Sieghart Sopper, Christiane Mummert, Christian Hofmann, Angela G. Hückelhoven, Silke Bergmann, Sandra M. Müller-Schmucker, Ellen G. Harrer, Jan Dörrie, Niels Schaft, Thomas Harrer, Laure Cardinaux, M.- L. Zahno, H.- R. Vogt, R. Zanoni, G. Bertoni, Maximilian Muenchhoff, Philip Goulder, Oliver Keppler, Stephanie Rebensburg, Markus Helfer, Yuwei Zhang, Huicheng Chen, Annie Bernier, Annie Gosselin, Jean- Pierre Routy, Birgitta Wöhrl, Anna Schneider, Angela Corona, Imke Spöring, Mareike Jordan, Bernd Buchholz, Elias Maccioni, Roberto Di Santo, Kristian Schweimer, Christian Schölz, Brian Weinert, Sebastian Wagner, Petra Beli, Yasuyuki Miyake, Jun Qi, Lars Jensen, Werner Streicher, Anna McCarthy, Nicholas Westwood, Sonia Lain, Jürgen Cox, Patrick Matthias, Matthias Mann, James Bradner, Chunaram Choudhary, Marcel Stern, Elena Valletta, Caterina Frezza, Francesca Marino-Merlo, Sandro Grelli, Anna Lucia Serafino, Antonio Mastino, Beatrice Macchi, Meike Kaulfuß, Sonja Windmann, Wibke Bayer, Sello Mikasi, Rebecca Heß, Michael Storcksdieck gen. Bonsmann, Carsten Kirschning, Bernd Lepenies, Anne Kolenbrander, Vladimir Temchura, Kenta Iijima, Junya Kobayashi, and Yukihito Ishizaka
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0301 basic medicine ,03 medical and health sciences ,030104 developmental biology ,Infectious Diseases ,Retroviral infection ,Virology ,Pandemic ,Biology ,Meeting Abstracts - Abstract
Table of contents Oral presentations Session 1: Entry & uncoating O1 Host cell polo-like kinases (PLKs) promote early prototype foamy virus (PFV) replication Irena Zurnic, Sylvia Hütter, Ute Lehmann, Nicole Stanke, Juliane Reh, Tobias Kern, Fabian Lindel, Gesche Gerresheim, Martin Hamann, Erik Müllers, Paul Lesbats, Peter Cherepanov, Erik Serrao, Alan Engelman, Dirk Lindemann O2 A novel entry/uncoating assay reveals the presence of at least two species of viral capsids during synchronized HIV-1 infection Claire Da Silva Santos, Kevin Tartour, Andrea Cimarelli O3 Dynamics of nuclear envelope association and nuclear import of HIV-1 complexes Rya Burdick, Jianbo Chen, Jaya Sastri, Wei-Shau Hu, Vinay Pathak O4 Human papillomavirus protein E4 potently enhances the susceptibility to HIV infection Oliver T. Keppler Session 2: Reverse transcription & integration O5 Structure and function of HIV-1 integrase post translational modifications Karine Pradeau, Sylvia Eiler, Nicolas Levy, Sarah Lennon, Sarah Cianferani, Stéphane Emiliani, Marc Ruff O6 Regulation of retroviral integration by RNA polymerase II associated factors and chromatin structure Vincent Parissi Session 3: Transcription and latency O7 A novel single-cell analysis pipeline to identify specific biomarkers of HIV permissiveness Sylvie Rato, Antonio Rausell, Miguel Munoz, Amalio Telenti, Angela Ciuffi O8 A capsid-dependent integration program linking T cell activation to HIV-1 gene expression Alexander Zhyvoloup, Anat Melamed, Ian Anderson, Delphine Planas, Janos Kriston-Vizi, Robin Ketteler, Chen-Hsuin Lee, Andy Merritt, Petronela Ancuta, Charles Bangham, Ariberto Fassati O9 Characterisation of new RNA polymerase III and RNA polymerase II transcriptional promoters in the Bovine Leukemia Virus genome Anthony Rodari, Benoit Van Driessche, Mathilde Galais, Nadége Delacourt, Sylvain Fauquenoy, Caroline Vanhulle, Anna Kula, Arsène Burny, Olivier Rohr, Carine Van Lint O10 Tissue-specific dendritic cells differentially modulate latent HIV-1 reservoirs Thijs van Montfort, Renee van der Sluis, Dave Speijer, Ben Berkhout Session 4: RNA trafficking & packaging O11 A novel cis-acting element affecting HIV replication Bo Meng, Andrzej Rutkowski, Neil Berry, Lars Dölken, Andrew Lever O12 Tolerance of HIV’s late gene expression towards stepwise codon adaptation Thomas Schuster, Benedikt Asbach, Ralf Wagner Session 5: Assembly & release O13 Importance of the tax-inducible actin-bundling protein fascin for transmission of human T cell leukemia virus Type 1 (HTLV-1) Christine Gross, Veit Wiesmann, Martina Kalmer, Thomas Wittenberg, Jan Gettemans, Andrea K. Thoma-Kress O14 Lentiviral nef proteins antagonize TIM-mediated inhibition of viral release Minghua Li, Eric O. Freed, Shan-Lu Liu Session 6: Pathogenesis & evolution O15 SEVI and semen prolong the half-life of HIV-1 Janis Müller, Jan Münch O16 CD169+ macrophages mediate retrovirus trans-infection of permissive lymphocytes to establish infection in vivo Xaver Sewald, Pradeep Uchil, Mark Ladinsky, Jagadish Beloor, Ruoxi Pi, Christin Herrmann, Nasim Motamedi, Thomas Murooka, Michael Brehm, Dale Greiner, Thorsten Mempel, Pamela Bjorkman, Priti Kumar, Walther Mothes O17 Efficient replication of a vpu containing SIVagm construct in African Green Monkeys requires an HIV-1 nef gene Simone Joas, Erica Parrish, Clement Wesley Gnanadurai, Edina Lump, Christina M. Stürzel, Nicholas F. Parrish, Ulrike Sauermann, Katharina Töpfer, Tina Schultheiss, Steven Bosinger, Guido Silvestri, Cristian Apetrei, Nicholas Huot, Michaela Müller-Trutwin, Daniel Sauter, Beatrice H. Hahn, Christiane Stahl-Hennig, Frank Kirchhoff O18 Reprogramming initiates mobilization of endogenous mutagenic LINE-1, Alu and SVA retrotransposons in human induced pluripotent stem cells with consequences for host gene expression Gerald Schumann, Sabine Jung-Klawitter, Nina V. Fuchs, Kyle R. Upton, Martin Muñoz-Lopez, Ruchi Shukla, Jichang Wang, Marta Garcia-Canadas, Cesar Lopez-Ruiz, Daniel J. Gerhardt, Attila Sebe, Ivana Grabundzija, Patricia Gerdes, Sylvia Merkert, Andres Pulgarin, Anja Bock, Ulrike Held, Anett Witthuhn, Alexandra Haase, Ernst J. Wolvetang, Ulrich Martin, Zoltán Ivics, Zsuzsanna Izsvák, J. Garcia-Perez, Geoffrey J. Faulkner O19 NF-κB activation induces expression of human endogenous retrovirus and particle production Tara Hurst, Aris Katzourakis, Gkikas Magiorkinis Session 7a and b: Innate sensing & intrinsic immunity O20 Identification of the phosphatase acting on T592 in SAMHD1 during M/G1 transition Kerstin Schott, Rita Derua, Janna Seifried, Andreas Reuter, Heike Schmitz, Christiane Tondera, Alberto Brandariz-Nuñez, Felipe Diaz-Griffero, Veerle Janssens, Renate König O21 Vpx overcomes a SAMHD1-independent block to HIV reverse transcription that is specific to resting CD4 T cells Hanna-Mari Baldauf, Lena Stegmann, Sarah-Marie Schwarz, Maud Trotard, Margarethe Martin, Gina Lenzi, Manja Burggraf, Xiaoyu Pan, Oliver I. Fregoso, Efrem S. Lim, Libin Abraham, Elina Erikson, Laura Nguyen, Ina Ambiel, Frank Rutsch, Renate König, Baek Kim, Michael Emerman, Oliver T. Fackler, Oliver T. Keppler O22 The role of SAMHD1 in antiviral restriction and immune sensing in the mouse Sabine Wittmann, Rayk Behrendt, Bianca Volkmann, Kristin Eissmann, Thomas Gramberg O23 T cells expressing reduced restriction factors are preferentially infected in therapy naïve HIV-1 patients Sebastian Bolduan, Herwig Koppensteiner, Stefanie Regensburg, Ruth Brack-Werner, Rika Draenert, Michael Schindler O24 cGAS-mediated innate immunity spreads through HIV-1 env-induced membrane fusion sites from infected to uninfected primary HIV-1 target cells Aurélie Ducroux, Shuting Xu, Aparna Ponnurangam, Sergej Franz, Angelina Malassa, Ellen Ewald, Christine Goffinet O25 Perturbation of innate RNA and DNA sensing by human T cell leukemia virus type 1 oncoproteins Sin-Yee Fung, Ching-Ping Chan, Chun-Kit Yuen, Kin-Hang Kok, Chin-Ping Chan, Dong-Yan Jin O26 Induction and anti-viral activity of Interferon α subtypes in HIV-1 infection Ulf Dittmer O27 Vpu-mediated counteraction of tetherin is a major determinant of HIV-1 interferon resistance Dorota Kmiec, Shilpa Iyer, Christina Stürzel, Daniel Sauter, Beatrice Hahn, Frank Kirchhoff O28 DNA repair protein Rad18 restricts HIV-1 and LINE-1 life cycle Yasuo Ariumi, Mariko Yasuda-Inoue, Koudai Kawano, Satoshi Tateishi, Priscilla Turelli O29 Natural mutations in IFITM3 allow escape from post-translational regulation and toggle antiviral specificity Alex Compton, Nicolas Roy, Françoise Porrot, Anne Billet, Nicoletta Casartelli, Jacob Yount, Chen Liang, Oliver Schwartz Session 8: Adaptive immunity & immune evasion O30 Observing evolution in HIV-1 infection: phylogenetics and mutant selection windows to infer the influence of the autologous antibody response on the viral quasispecies Carsten Magnus, Lucia Reh, Penny Moore, Therese Uhr, Jacqueline Weber, Lynn Morris, Alexandra Trkola O31 Dose and subtype specific analyses of the anti-HIV effects of IFN-alpha family members Rashel V. Grindberg, Erika Schlaepfer, Gideon Schreiber, Viviana Simon, Roberto F. Speck Session 9: Novel antiviral strategies O32 LEDGIN-mediated inhibition of the integrase-LEDGF/p75 interaction reduces reactivation of residual latent HIV Zeger Debyser, Lenard Vranckx, Jonas Demeulemeester, Suha Saleh, Eric Verdin, Anna Cereseto, Frauke Christ, Rik Gijsbers O33 NKG2D-mediated clearance of reactivated viral reservoirs by natural killer cells O34 Inhibition of HIV reactivation in brain cells by AAV-mediated delivery of CRISPR/Cas9 O35 CRISPR-Cas9 as antiviral: potent HIV-1 inhibition, but rapid virus escape and the subsequent design of escape-proof antiviral strategies Ben Berkhout, Gang Wang, Na Zhao, Atze T. Das Session 10: Recent advances in HIV vaccine development O36 Priming with a potent HIV-1 DNA vaccine frames the quality of T cell and antibody responses prior to a poxvirus and protein boost Benedikt Asbach, Josef Köstler, Beatriz Perdiguero, Mariano Esteban, Bertram L. Jacobs, David C. Montefiori, Celia C. LaBranche, Nicole L. Yates, Georgia D. Tomaras, Guido Ferrari, Kathryn E. Foulds, Mario Roederer, Gary Landucci, Donald N. Forthal, Michael S. Seaman, Natalie Hawkins, Steven G. Self, Sanjay Phogat, James Tartaglia, Susan W. Barnett, Brian Burke, Anthony D. Cristillo, Song Ding, Jonathan L. Heeney, Giuseppe Pantaleo, Ralf Wagner O37 Passive immunisation with a neutralising antibody against HIV-1 Env prevents infection of the first cells in a mucosal challenge rhesus monkey model Christiane Stahl-Hennig, Viktoria Stab, Armin Ensser, Ulrike Sauermann, Bettina Tippler, Dennis Burton, Matthias Tenbusch, Klaus Überla O38 HIV antibody Fc-glycoforms drive B cell affinity maturation Galit Alter, Giuseppe Lofano, Anne-Sophie Dugast, Viraj Kulkarni, Todd Suscovich Poster presentations Topic 1: Entry & uncoating P1 Dynein light chain is required for murine leukemia virus infection Tatiana Opazo, Felipe Barraza, Diego Herrera, Andrea Garces, Tomas Schwenke, Diego Tapia, Jorge Cancino, Gloria Arriagada P2 Peptide paratope mimics of the broadly neutralising HIV-1 antibody b12 Christina Haußner, Dominik Damm, Anette Rohrhofer, Barbara Schmidt, Jutta Eichler P3 Investigating cellular pathways involved in the transmission of HIV-1 between dendritic cells and T cells using RNAi screening techniques Rebecca Midgley, James Wheeldon, Vincent Piguet P4 Co-receptor tropism in HIV-1, HIV-2 monotypic and dual infections Priyanka Khopkar, Megha Rohamare, Smita Kulkarni P5 Characterisation of the role of CIB1 and CIB2 as HIV-1 helper factors Ana Godinho-Santos, Allan Hance, Joao Goncalves, Fabrizio Mammano P6 Buffering deleterious polymorphisms in the highly constrained C2 region of HIV-1 envelope by the flexible V3 domain Romain Gasser, Meriem Hamoudi, Martina Pellicciotta, Zhicheng Zhou, Clara Visdeloup, Philippe Colin, Martine Braibant, Bernard Lagane, Matteo Negroni P7 Entry inhibition of HERV-K(HML-2) by an Env-IgG fusion protein Jula Wamara, Norbert Bannert Topic 2: Reverse transcription & integration P8 The R263K/H51Y resistance substitutions in HIV integrase decreases levels of integrated HIV DNA over time Thibault Mesplede, Nathan Osman, Kaitlin Anstett, Jiaming Calvin Liang, Hanh Thi Pham, Mark Wainberg P9 The Retrovirus Integration Database (RID) Wei Shao, Jigui Shan, Mary Kearney, Xiaolin Wu, Frank Maldarelli, John Mellors, Brian Luke, John Coffin, Stephen Hughes P10 The small molecule 3G11 inhibits HIV-1 reverse transcription Thomas Fricke, Silvana Opp, Caitlin Shepard, Dmitri Ivanov, Baek Kim, Jose Valle-Casuso, Felipe Diaz-Griffero P11 Dual and opposite regulation of HIV-1 integration by hRAD51: impact on therapeutical approaches using homologous DNA repair modulators Vincent Parissi P12 A flexible motif essential for integration by HIV-1 integrase Marine Kanja, Pierre Cappy, Matteo Negroni, Daniela Lener P13 Interaction between HIV-1 integrase and the host protein Ku70: identification of the binding site and study of the influence on integrase-proteasome interplay Ekaterina Knyazhanskaya, Andrey Anisenko, Timofey Zatsepin, Marina Gottikh P14 Normalisation based method for deep sequencing of somatic retroelement integrations in human genome Alexander Komkov, Anastasia Minervina, Gaiaz Nugmanov, Vadim Nazarov, Konstantin Khodosevich, Ilgar Mamedov, Yuri Lebedev Topic 3: Transcription and latency P15 BCA2/RABRING7 restricts HIV-1 transcription by preventing the nuclear translocation of NF-κB Marta Colomer-Lluch, Ruth Serra-Moreno P16 MATR3 post-transcriptional regulation of HIV-1 transcription during latency Ambra Sarracino, Anna Kula, Lavina Gharu, Alexander Pasternak, Carine Van Lint, Alessandro Marcello P17 HIV-1 tat intersects the SUMO pathway to regulate HIV-1 promoter activity Ann Marie McCartin, Anurag Kulkarni, Valentin Le Douce, Virginie Gautier P18 Conservation in HIV-1 Vpr guides tertiary gRNA folding and alternative splicing Ann Baeyens, Evelien Naessens, Anouk Van Nuffel, Karin Weening, Anne-Marie Reilly, Eva Claeys, Wim Trypsteen, Linos Vandekerckhove, Sven Eyckerman, Kris Gevaert, Bruno Verhasselt P19 The majority of reactivatable latent HIV are genetically distinct Hoi Ping Mok, Nicholas Norton, Axel Fun, Jack Hirst, Mark Wills, Andrew Lever P20 Do mutations in the tat exonic splice enhancer contribute to HIV-1 latency? Nicholas Norton, Hoi Ping Mok, Jack Hirst, Andrew Lever P21 Culture-to-Ct: A fast and direct RT-qPCR HIV gene reactivation screening method using primary T cell culture Valentin Le Douce, Ann Marie McCartin, Virginie Gautier P22 A novel approach to define populations of early silenced proviruses Dalibor Miklik, Filip Senigl, Jiri Hejnar Topic 4: RNA trafficking & packaging P23 Functional analysis of the structure and conformation of HIV-1 genome RNA DIS Jun-ichi Sakuragi, Sayuri Sakuragi, Masaru Yokoyama, Tatsuo Shioda, Hironori Sato P24 Regulation of foamy viral env splicing controls gag and pol expression Jochen Bodem, Rebecca Moschall, Sarah Denk, Steffen Erkelenz, Christian Schenk, Heiner Schaal Topic 5: Assembly & release P25 Transfer of HTLV-1 p8 to target T cells depends on VASP: a novel interaction partner of p8 Norbert Donhauser, Ellen Socher, Sebastian Millen, Heinrich Sticht, Andrea K. Thoma-Kress P26 COL4A1 and COL4A2 are novel HTLV-1 tax targets with a putative role in virus transmission Christine Gross, Sebastian Millen, Melanie Mann, Klaus Überla, Andrea K. Thoma-Kress P27 The C terminus of foamy virus gag protein is required for particle formation, and virus budding: starting assembly at the C terminus? Guochao Wei, Matthew J. Betts, Yang Liu, Timo Kehl, Robert B. Russell, Martin Löchelt P28 Generation of an antigen-capture ELISA and analysis of Rec and Staufen-1 effects on HERV-K(HML-2) virus particle production Oliver Hohn, Saeed Mostafa, Kirsten Hanke, Stephen Norley, Norbert Bannert P29 Antagonism of BST-2/tetherin is a conserved function of primary HIV-2 Env glycoproteins Chia-Yen Chen, Masashi Shingai, Pedro Borrego, Nuno Taveira, Klaus Strebel P30 Mutations in the packaging signal region of the HIV-1 genome cause a late domain mutant phenotype Chris Hellmund, Bo Meng, Andrew Lever P31 p6 regulates membrane association of HIV-1 gag Melanie Friedrich, Friedrich Hahn, Christian Setz, Pia Rauch, Kirsten Fraedrich, Alina Matthaei, Petra Henklein, Maximilian Traxdorf, Torgils Fossen, Ulrich Schubert Topic 6: Pathogenesis & evolution P32 Molecular and structural basis of protein evolution during viral adaptation Aya Khwaja, Meytal Galilee, Akram Alian P33 HIV-1 enhancement and neutralisation by soluble gp120 and its role for the selection of the R5-tropic “best fit” Birco Schwalbe, Heiko Hauser, Michael Schreiber P34 An insertion of seven amino acids in the Env cytoplasmic tail of Human Immunodeficiency Virus type 2 (HIV-2) selected during disease progression enhances viral replication François Dufrasne, Mara Lucchetti, Patrick Goubau, Jean Ruelle P35 Cell-associated HIV-1 unspliced to multiply spliced RNA ratio at 12 weeks ART correlates with markers of immune activation and apoptosis and predicts the CD4 T-cell count at 96 weeks ART Mirte Scherpenisse, Ben Berkhout, Alexander Pasternak P36 Faster progression in non-B subtype HIV-1-infected patients than Korean subclade of subtype B is accompanied by higher variation and no induction of gross deletion in non-B nef gene by Korean red ginseng treatment Young-Keol Cho, Jungeun Kim, Daeun Jeong P37 Aberrant expression of ERVWE1 endogenous retrovirus and overexpression of TET dioxygenases are characteristic features of seminoma Katerina Trejbalova, Martina Benesova, Dana Kucerova, Zdenka Vernerova, Rachel Amouroux, Petra Hajkova, Jiri Hejnar P38 Life history of the oldest lentivirus: characterisation of ELVgv integrations and the TRIM5 selection pattern in dermoptera Daniel Elleder, Tomas Hron, Helena Farkasova, Abinash Padhi, Jan Paces P39 Characterisation of a highly divergent endogenous retrovirus in the equine germ line Henan Zhu, Robert Gifford, Pablo Murcia P40 The emergence of pandemic retroviral infection in small ruminants Maria Luisa Carrozza, Anna-Maria Niewiadomska, Maurizio Mazzei, Mounir Abi-Said, Joseph Hughes, Stéphane Hué, Robert Gifford P41 Near full-length genome (NFLG) Characterisation of HIV-1 subtype B identified in South Africa Adetayo Obasa, Graeme Jacobs, Susan Engelbrecht P42 Acquisition of Vpu-mediated tetherin antagonism by an HIV-1 group O strain Katharina Mack, Kathrin Starz, Daniel Sauter, Matthias Geyer, Frederic Bibollet-Ruche, Christina Stürzel, Marie Leoz, Jean Christophe Plantier, Beatrice H. Hahn, Frank Kirchhoff P43 The human endogenous retrovirus type K is involved in cancer stem cell markers expression and in human melanoma malignancy Ayele Argaw-Denboba, Emanuela Balestrieri, Annalucia Serafino, Ilaria Bucci, Chiara Cipriani, Corrado Spadafora, Paolo Sinibaldi-Vallebona, Claudia Matteucci P44 Natural infection of Indian non-human primates by unique lentiviruses S. Nandi Jayashree, Ujjwal Neogi, Anil K. Chhangani, Shravan Sing Rathore, Bajrang R. J. Mathur P45 Free cervical cancer screening among HIV-positive women receiving antiretroviral treatment in Nigeria Adeyemi Abati P46 Molecular evolutionary status of feline immunodeficiency virus in Turkey B. Taylan Koç, Tuba Çiğdem Oğuzoğlu Topic 7: Innate sensing & intrinsic immunity P47 Cell-to-cell contact with HTLV-1-infected T cells reduces dendritic cell immune functions and contributes to infection in trans. Takatoshi Shimauchi, Stephan Caucheteux, Jocelyn Turpin, Katja Finsterbusch, Charles Bangham, Yoshiki Tokura, Vincent Piguet P48 Deciphering the mechanisms of HIV-1 exacerbation induced by Mycobacterium tuberculosis in monocytes/macrophages Shanti Souriant, Luciana Balboa, Karine Pingris, Denise Kviatcowsky, Brigitte Raynaud-Messina, Céline Cougoule, Ingrid Mercier, Marcelo Kuroda, Pablo González-Montaner, Sandra Inwentarz, Eduardo Jose Moraña, Maria del Carmen Sasiain, Olivier Neyrolles, Isabelle Maridonneau-Parini, Geanncarlo Lugo-Villarino, Christel Vérollet P49 The SAMHD1-mediated inhibition of LINE-1 retroelements is regulated by phosphorylation Alexandra Herrmann, Sabine Wittmann, Caitlin Shepard, Dominique Thomas, Nerea Ferreirós Bouzas, Baek Kim, Thomas Gramberg P50 Activities of nuclear envelope protein SUN2 in HIV infection Xavier Lahaye, Anvita Bhargava, Takeshi Satoh, Matteo Gentili, Silvia Cerboni, Aymeric Silvin, Cécile Conrad, Hakim Ahmed-Belkacem, Elisa C. Rodriguez, Jean-François Guichou, Nathalie Bosquet, Matthieu Piel, Roger Le Grand, Megan King, Jean-Michel Pawlotsky, Nicolas Manel P51 Activation of TLR7/8 with a small molecule agonist induces a novel restriction to HIV-1 infection of monocytes Henning Hofmann, Benedicte Vanwalscappel, Nicolin Bloch, Nathaniel Landau P52 Steady state between the DNA polymerase and Rnase H domain activities of reverse transcriptases determines the sensitivity of retroviruses to inhibition by APOBEC3 proteins Stanislav Indik, Benedikt Hagen P53 HIV restriction in mature dendritic cells is related to p21 induction and p21-mediated control of the dNTP pool and SAMHD1 activity. José Carlos Valle-Casuso, Awatef Allouch, Annie David, Françoise Barré-Sinoussi, Michaela Müller-Trutwin, Monsef Benkirane, Gianfranco Pancino, Asier Saez-Cirion P54 IFITM protens restrict HIV-1 protein synthesis Wing-Yiu Lee, Chen Liang, Richard Sloan P55 Characterisation and functional analysis of the novel restriction factor Serinc5 Bianca Schulte, Silvana Opp, Felipe Diaz-Griffero P56 piRNA sequences are common in Human Endogenous Retroviral Sequences (HERVs): An antiretroviral restriction mechanism? Jonas Blomberg, Luana Vargiu, Patricia Rodriguez-Tomé, Enzo Tramontano, Göran Sperber P57 Ferroportin restricts HIV-1 infection in sickle cell disease Namita Kumari, Tatiana Ammosova, Sharmeen Diaz, Patricia Oneal, Sergei Nekhai P58 APOBEC3G modulates the response to antiretroviral drugs in humanized mice Audrey Fahrny, Gustavo Gers-Huber, Annette Audigé, Roberto F. Speck, Anitha Jayaprakash, Ravi Sachidanandam, Matt Hernandez, Marsha Dillon-White, Viviana Simon P59 High-throughput epigenetic analysis of evolutionarily young endogenous retrovirus presents in the mule deer (Odocoileus hemionus) genome Tomas Hron, Helena Farkasova, Daniel Elleder P60 Characterisation of the expression of novel endogenous retroviruses and immune interactions in a macaque model Neil Berry, Emmanuel Maze, Claire Ham, Neil Almond, Greg Towers, Robert Belshaw P61 HIV-1 restriction by orthologs of SERINC3 and SERINC5 Patrícia de Sousa-Pereira, Joana Abrantes, Massimo Pizzato, Pedro J. Esteves, Oliver T. Fackler, Oliver T. Keppler, Hanna-Mari Baldauf P62 TRIM19/PML restricts HIV infection in a cell type-dependent manner Bianca Volkmann, Tanja Kahle, Kristin Eissmann, Alexandra Herrmann, Sven Schmitt, Sabine Wittmann, Laura Merkel, Nina Reuter, Thomas Stamminger, Thomas Gramberg P63 Recent invasion of the mule deer genome by a retrovirus Helena Farkasova, Tomas Hron, Daniel Elleder P64 Does the antiviral protein SAMHD1 influence mitochondrial function? Ilaria Dalla Rosa, Kate Bishop, Antonella Spinazzola, Harriet Groom P65 cGAMP transfers intercellularly via HIV-1 Env-mediated cell–cell fusion sites and triggers an innate immune response in primary target cells Shuting Xu, Aurélie Ducroux, Aparna Ponnurangam, Sergej Franz, Gabrielle Vieyres, Mathias Müsken, Thomas Zillinger, Angelina Malassa, Ellen Ewald, Veit Hornung, Winfried Barchet, Susanne Häussler, Thomas Pietschmann, Christine Goffinet P66 Pre-infection transcript levels of FAM26F in PBMCS inform about overall plasma viral load in acute and postacute phase after SIV-infection Ulrike Sauermann, Aneela Javed, Nicole Leuchte, Gabriela Salinas, Lennart Opitz, Christiane Stahl-Hennig, Sieghart Sopper P67 Sequence-function analysis of three T cell receptors targeting the HIV-1 p17 epitope SLYNTVATL Christiane Mummert, Christian Hofmann, Angela G. Hückelhoven, Silke Bergmann, Sandra M. Müller-Schmucker, Ellen G. Harrer, Jan Dörrie, Niels Schaft, Thomas Harrer P68 An immunodominant region of the envelope glycoprotein of small ruminant lentiviruses may function as decoy antigen Laure Cardinaux, M.-L. Zahno, H.-R. Vogt, R. Zanoni, G. Bertoni P69 Impact of immune activation, immune exhaustion, broadly neutralising antibodies and viral reservoirs on disease progression in HIV-infected children Maximilian Muenchhoff, Philip Goulder, Oliver Keppler Topic 9: Novel antiviral strategies P70 Identification of natural compounds as new antiviral products by bioassay-guided fractionation Alexandra Herrmann, Stephanie Rebensburg, Markus Helfer, Michael Schindler, Ruth Brack-Werner P71 The PPARG antagonism disconnects the HIV replication and effector functions in Th17 cells Yuwei Zhang, Huicheng Chen, Delphine Planas, Annie Bernier, Annie Gosselin, Jean-Pierre Routy, Petronela Ancuta P72 Characterisation of a multiresistant subtype AG reverse transcriptase: AZT resistance, sensitivity to RNase H inhibitors and inhibitor binding Birgitta Wöhrl, Anna Schneider, Angela Corona, Imke Spöring, Mareike Jordan, Bernd Buchholz, Elias Maccioni, Roberto Di Santo, Jochen Bodem, Enzo Tramontano, Kristian Schweimer P73 Insigths into the acetylation pattern of HDAC inhibitors and their potential role in HIV therapy Christian Schölz, Brian Weinert, Sebastian Wagner, Petra Beli, Yasuyuki Miyake, Jun Qi, Lars Jensen, Werner Streicher, Anna McCarthy, Nicholas Westwood, Sonia Lain, Jürgen Cox, Patrick Matthias, Matthias Mann, James Bradner, Chunaram Choudhary P74 HPV-derived and seminal amyloid peptides enhance HIV-1 infection and impair the efficacy of broadly neutralising antibodies and antiretroviral drugs Marcel Stern, Oliver T. Keppler P75 D(−)lentiginosine inhibits both proliferation and virus expression in cells infected by HTLV-1 in vitro Elena Valletta, Caterina Frezza, Claudia Matteucci, Francesca Marino-Merlo, Sandro Grelli, Anna Lucia Serafino, Antonio Mastino, Beatrice Macchi P76 HIV-1 resistance analyses of the Cape Winelands districts, South Africa Sello Mikasi, Graeme Jacobs, Susan Engelbrecht Topic 10: Recent advances in HIV vaccine development P77 Induction of complex retrovirus antigen-specific immune responses by adenovirus-based vectors depends on the order of vector administration Meike Kaulfuß, Sonja Windmann, Wibke Bayer P78 Direct impact of structural properties of HIV-1 Env on the regulation of the humoral immune response Rebecca Heß, Michael Storcksdieck gen. Bonsmann, Viktoria Stab, Carsten Kirschning, Bernd Lepenies, Matthias Tenbusch, Klaus Überla P79 Lentiviral virus-like particles mediate gerenration of T-follicular helper cells in vitro Anne Kolenbrander, Klaus Überla, Vladimir Temchura P80 Recruitment of HIV-1 Vpr to DNA damage sites and protection of proviral DNA from nuclease activity Kenta Iijima, Junya Kobayashi, Yukihito Ishizaka
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315. Mineral composition of atmospheric dust in Biebrza National Park, Poland
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Tondera, A., Jabłońska, M., and Janusz Janeczek
316. Combined Sewer Overflows: A critical review on best practice and innovative solutions to mitigate impacts on environment and human health
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Botturi, Alice, E. Gozde Ozbayram, Tondera, Katharina, Gilbert, Nathalie I., Rouault, Pascale, Caradot, Nicolas, Gutierrez, Oriol, Daneshgar, Saba, Frison, Nicola, Çağrı Akyol, Foglia, Alessia, Eusebi, Anna Laura, and Fatone, Francesco
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Combined sewer overflows ,13. Climate action ,nature based solutions ,urban water management ,water quality ,sewer system - Abstract
Combined sewer overflows (CSOs) are of major environmental concern for impacted surface waterbodies. In the last decades, major storm events have become increasingly regular in some areas, and meteorological scenarios predict a further rise in their frequency. Consequently, control and treatment of CSOs with respect to best practice examples, innovative treatment solutions and management of sewer systems is an inevitable necessity. As a result, the number of publications concerning quality, quantity and type of treatments has recently increased. This review therefore aims to provide a critical overview on the effects, control and treatment of CSOs in terms of impact on the environment and public health, strict measures addressed by regulations, and the various treatment alternatives including natural and compact treatments. Drawing together the previous studies, an innovative treatment and control guideline is also proposed for the better management practices., The authors acknowledge the European Union's Horizon2020 research and innovation programme for co-funding INTCATCH innovation action under grant agreement No.689341.
317. Results of geophysical research performed on A4 highway in the service area Wirek and Halemba.
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Zych J., Machowski M., Tondera M., Zych J., Machowski M., and Tondera M.
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A section of the A4 highway in Poland passes through several active coal mining areas with various geotechnical characteristics between the Batory junction in Chorzow and the Sosnica junction in Gliwice. There are also several faults, the most significant being the ‘third fault’ which outcrops near the Wirek and Halemba service areas and intersects the A4 in the vicinity of the KP-11 footbridge. The large amount of geotechnical information available was not noted or used during the design or construction phases, resulting in problems including craters which appeared in the south part of the Halema service area after a rainstorm. Investigations including the use of ground penetrating radar have been carried out to provide an accurate assessment of the geological strata in the area., A section of the A4 highway in Poland passes through several active coal mining areas with various geotechnical characteristics between the Batory junction in Chorzow and the Sosnica junction in Gliwice. There are also several faults, the most significant being the ‘third fault’ which outcrops near the Wirek and Halemba service areas and intersects the A4 in the vicinity of the KP-11 footbridge. The large amount of geotechnical information available was not noted or used during the design or construction phases, resulting in problems including craters which appeared in the south part of the Halema service area after a rainstorm. Investigations including the use of ground penetrating radar have been carried out to provide an accurate assessment of the geological strata in the area.
318. Development of a railway embankment in Glogow copper smelter by use of innovative copper slag aggregate.
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Machowski M., Gambal P., Kordiumow R., Koziel E., Lopatka A., Tondera M., Machowski M., Gambal P., Kordiumow R., Koziel E., Lopatka A., and Tondera M.
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The use is described of Cu slag aggregate for the construction of a railway embankment at the Glogow Cu smelter in Poland. The embankment was reinforced with geosynthetic material. Analyses of the stability of the embankment and the subsoil consolidation process are presented., The use is described of Cu slag aggregate for the construction of a railway embankment at the Glogow Cu smelter in Poland. The embankment was reinforced with geosynthetic material. Analyses of the stability of the embankment and the subsoil consolidation process are presented.
319. Dealing with the consequences of the mining industry and requirements on active operation and future planning.
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Meier G., Klapperich H., Tondera D., Meier G., Klapperich H., and Tondera D.
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Problems associated with support structures in disused mines are discussed. The main issues have to date been with timber and stone or brick walling supports which are subject to degradation and oxidation processes as a result of the combined effect of oxygen and water. The concrete and steel employed in modern mines are more stable and have a longer life than wooden supports but may also be affected by natural degradation processes, and this must be taken into account in future planning. The effects of different conditions and processes on the various categories of support materials in old German mines are discussed with photographic illustrations of intensive fungal growth on wooden supports after six months, convergence of stone walls, mortar solution loss from brickwork, damage to sprayed concrete by sulphate influx, and severe corrosion of steel supports in the Rothschonberger adit. In sulphide ore mines and many coal mines, the oxidation of pyrite and other sulphides and the hydrolysis of metal ions such as Al3+ and Mn2+ give rise to hydrogen ions that substantially reduce the pH level, resulting in corrosive acid mine drainage. Conversely, timbers submerged underwater in flooded mines can be preserved intact for many years because of the lack of oxygen., Problems associated with support structures in disused mines are discussed. The main issues have to date been with timber and stone or brick walling supports which are subject to degradation and oxidation processes as a result of the combined effect of oxygen and water. The concrete and steel employed in modern mines are more stable and have a longer life than wooden supports but may also be affected by natural degradation processes, and this must be taken into account in future planning. The effects of different conditions and processes on the various categories of support materials in old German mines are discussed with photographic illustrations of intensive fungal growth on wooden supports after six months, convergence of stone walls, mortar solution loss from brickwork, damage to sprayed concrete by sulphate influx, and severe corrosion of steel supports in the Rothschonberger adit. In sulphide ore mines and many coal mines, the oxidation of pyrite and other sulphides and the hydrolysis of metal ions such as Al3+ and Mn2+ give rise to hydrogen ions that substantially reduce the pH level, resulting in corrosive acid mine drainage. Conversely, timbers submerged underwater in flooded mines can be preserved intact for many years because of the lack of oxygen.
320. New wheelchair technology
- Author
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Seeliger, K., primary, Klosner, H., additional, Tondera, K. L., additional, and Engel, P., additional
- Published
- 1985
- Full Text
- View/download PDF
321. New wheelchair technology
- Author
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P. Engel, H. Klosner, K. L. Tondera, and K. Seeliger
- Subjects
medicine.medical_specialty ,Engineering ,Wheelchair ,Physical medicine and rehabilitation ,business.industry ,Rehabilitation ,medicine ,Physical Therapy, Sports Therapy and Rehabilitation ,business - Published
- 1985
322. Electrically Controlled Click‐Chemistry for Assembly of Bioactive Hydrogels on Diverse Micro‐ and Flexible Electrodes
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Aruã Clayton Da Silva, Teuku Fawzul Akbar, Thomas Edward Paterson, Carsten Werner, Christoph Tondera, and Ivan Rusev Minev
- Subjects
Polymers and Plastics ,Organic Chemistry ,Materials Chemistry ,Hydrogels ,Click Chemistry ,Electrodes ,Polyethylene Glycols ,Polymerization - Abstract
The seamless integration of electronics with living matter requires advanced materials with programmable biological and engineering properties. Here electrochemical methods to assemble semi-synthetic hydrogels directly on electronically conductive surfaces are explored. Hydrogels consisting of poly (ethylene glycol) (PEG) and heparin building blocks are polymerized by spatially controlling the click reaction between their thiol and maleimide moieties. The gels are grown as conformal coatings or 2D patterns on ITO, gold, and PtIr. This study demonstrates that such coatings significantly influence the electrochemical properties of the metal-electrolyte interface, likely due to space charge effects in the gels. Further a promising route toward engineering and electrically addressable extracellular matrices by printing arrays of gels with binary cell adhesiveness on flexible conductive surfaces is highlighted.
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323. Zweihundert Jahre deutsche Finnlandbegeisterung.
- Author
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Tondera, Benedikt
- Abstract
The article presents a review for the book "Zweihundert Jahre deutsche Finnlandbegeisterung," which was edited by Robert Schweitzer.
- Published
- 2011
324. Empire of friends: Soviet power and socialist internationalism in Cold War Czechoslovakia: by Rachel Applebaum, Ithaca and London, Cornell University Press, 2019, 294 pp., US$49.95 (hardcover), ISBN 978-1-5017-3557-8.
- Author
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Tondera, Benedikt
- Published
- 2020
- Full Text
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325. Who Is Qualified to Perform Manipulations?
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Tondera, Harold B.
- Abstract
An excerpt from the article "Who is Qualified to Perform Manipulations?," by Dr. Chester Y. Smith is presented.
- Published
- 2008
326. Praise for ACA news.
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Tondera HB
- Published
- 2008
327. Successful Chiropractic Hospital Models.
- Author
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Bernstein, Michael A. and Tondera, Harold B.
- Abstract
A letter to the editor is presented in response to the article "Uncharted Territory--Chiropractors in Pursuit of Hospital Privileges," in the January 2008 issue.
- Published
- 2008
328. Biocompatibility and inflammatory response in vitro and in vivo to gelatin-based biomaterials with tailorable elastic properties.
- Author
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Ullm, Sandra, Krüger, Anne, Tondera, Christoph, Gebauer, Tim P., Neffe, Axel T., Lendlein, Andreas, Jung, Friedrich, and Pietzsch, Jens
- Subjects
- *
BIOCOMPATIBILITY , *INFLAMMATION , *GELATIN , *BIOMATERIALS , *CYCLOOXYGENASES , *CYTOKINES - Abstract
Hydrogels prepared from gelatin and lysine diisocyanate ethyl ester provide tailorable elastic properties and degradation behavior. Their interaction with human aortic endothelial cells (HAEC) as well as human macrophages (Mɸ) and granulocytes (Gɸ) were explored. The experiments revealed a good biocompatibility, appropriate cell adhesion, and cell infiltration. Direct contact to hydrogels, but not contact to hydrolytic or enzymatic hydrogel degradation products, resulted in enhanced cyclooxygenase-2 (COX-2) expression in all cell types, indicating a weak inflammatory activation in vitro . Only Mɸ altered their cytokine secretion profile after direct hydrogel contact, indicating a comparably pronounced inflammatory activation. On the other hand, in HAEC the expression of tight junction proteins, as well as cytokine and matrix metalloproteinase secretion were not influenced by the hydrogels, suggesting a maintained endothelial cell function. This was in line with the finding that in HAEC increased thrombomodulin synthesis but no thrombomodulin membrane shedding occurred. First in vivo data obtained after subcutaneous implantation of the materials in immunocompetent mice revealed good integration of implants in the surrounding tissue, no progredient fibrous capsule formation, and no inflammatory tissue reaction in vivo . Overall, the study demonstrates the potential of gelatin-based hydrogels for temporal replacement and functional regeneration of damaged soft tissue. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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329. Modelling Under Varying Flows
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Rizzo, Anacleto, Pálfy, Tamás Gábor, Forquet, Nicolas, Tondera, Katharina, editor, Blecken, Godecke-Tobias, editor, Chazarenc, Florent, editor, and Tanner, Chris C., editor
- Published
- 2018
- Full Text
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330. Elimination of micropollutants in four test-scale constructed wetlands treating combined sewer overflow: Influence of filtration layer height and feeding regime.
- Author
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Ruppelt, Jan P., Pinnekamp, Johannes, and Tondera, Katharina
- Subjects
- *
COMBINED sewer overflows , *CONSTRUCTED wetlands , *BISPHENOL A , *BODIES of water , *MICROPOLLUTANTS , *FILTERS & filtration - Abstract
Municipal wastewater can contain large amounts of organic micropollutants. Some of these substances are harmful to the environment, even at low concentrations, e.g. when being discharged untreated into surface water bodies in case of combined sewer overflows (CSOs) during or after heavy rainfall events. Constructed wetlands can be very effective in treating CSOs. To date, there have only been few investigations about the retention of micropollutants using retention soil filters (RSFs), which basically are vertical flow constructed wetlands with an additional retention area. Thus, focus of this study was set on the interaction between dry periods, loading events, filter operation time, and the resulting removal of micropollutants originating from CSOs. The removal of 1-H-benzotriazole, carbamazepine, diclofenac, metoprolol, sulfamethoxazole and bisphenol A was examined in four test-scale RSFs. Removal efficiencies of approximately 70% were found for metoprolol. 1-H-benzotriazole, diclofenac and bisphenol A were removed moderately between 30 and 40%. For carbamazepine and sulfamethoxazole, negative retention rates were found. No significant correlations were found between removal efficiencies and the length of the antecedent dry period and/or filter operation time. However, the study showed that removal efficiencies depend strongly on respective inflow concentrations. Thickness of the filter layer seems to have an influence as well; does not lead to uniform results, though. Image 1 • RSFs remove metoprolol, 1-H-benzotriazole, diclofenac and Bisphenol A. • Influent concentrations are decisive for most removal efficiencies. • Dry periods and filter age do not influence removal efficiencies significantly. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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331. Are floating treatment wetlands more suitable for retrofitting highway runoff basins than vertical-flow treatment wetlands?
- Author
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Wirtz, Hannah, Ruppelt, Jan P., Schippers, Jos H.M., Neinhuis, Andrea E., Luetjens, Laura, van Dongen, Joost T., Pinnekamp, Johannes, and Tondera, Katharina
- Subjects
- *
POLYCYCLIC aromatic hydrocarbons , *SETTLING basins , *RUNOFF , *STORM water retention basins , *WATER table , *RETROFITTING , *STORMWATER infiltration - Abstract
Highway runoffs introduce numerous traffic-related pollutants – such as heavy metals, suspended solids and different kinds of hydrocarbons – into surface waters, thus endangering environmental health. In Germany, sedimentation basins with oil retention baffles are mandatory for the treatment of highway runoff in water protection areas. If the distance to the groundwater table is too low, further treatment with event-loaded vertical-flow treatment wetlands (VFWs) is required. In this study, we evaluated if retrofitting of stormwater retention basins to floating treatment wetlands (FTWs) can serve as an alternative to post-treatment VFWs and if native plant species could adapt to the oxygen-deprived salt-enriched environment. Two such basins with two hydraulically separated parallel chambers each near the municipality of Cologne were equipped with floating mats on one chamber, while the other one served as control. One location additionally had hydraulically separated post-treatment VFWs, allowing for a comparison with the treatment efficiency of the FTW. The removal of chloride, sulfate, suspended solids (total and < 63 μm), nutrients, metals, petroleum derived hydrocarbons and polycyclic aromatic hydrocarbons (PDH and PAH) was examined in 54 events over a period of two years. As a result, it was found that plants can create an intense root network despite hostile conditions in the basins. For the target parameters (TSS 63 , PAH and PDH), the removal efficiency of the stormwater retention basin was already sufficient. For metals and ammonium nitrogen, the VFWs proved to be more efficient, whereas for nitrate nitrogen, this was the case for FTWs. None of the treatment systems proved effective against reducing chloride concentration from deicing salts. [Display omitted] [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
332. [Solar retinopathy. Rare cause of acute loss of vision].
- Author
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Weber P, Kurlemann G, Lunecke C, and Tondera A
- Subjects
- Adolescent, Blindness drug therapy, Diagnosis, Differential, Electroencephalography, Electrophysiology, Evoked Potentials, Visual, Female, Fluorescein Angiography, Fundus Oculi, Humans, Macula Lutea pathology, Neurologic Examination, Ophthalmic Solutions, Papilledema etiology, Prednisolone administration & dosage, Prednisolone therapeutic use, Prognosis, Radiation Injuries complications, Retinal Diseases complications, Scotoma etiology, Tomography, X-Ray Computed, Blindness etiology, Radiation Injuries etiology, Retinal Diseases etiology, Sunlight adverse effects
- Abstract
History and Clinical Findings: A 15-year-old girl was admitted to hospital for acute bilateral visual deterioration and central scotoma of two days' duration. It became known on the third day that she had looked into the sun on several occasions, for several minutes at a time., Investigations: In addition to the scotoma there was a visual loss to 0.05 in the right and 0.1 in the left eye. Neurological examination and imaging of the head were unremarkable. At first the visual evoked potential was prolonged (122 ms on right, 130 ms on left), but all other electrophysiological tests were normal. Fundoscopy at first showed macular oedema and pigment changes in the macula., Treatment and Course: Local application of prednisolone (0.5 mg five times daily) gradually improved the vision and it returned to normal after 8 weeks. The initially prolonged visual evoked potential restored to normal either. No pathophysiological reason for this was found., Conclusion: In case of acute loss of vision in the absence of other neurological findings, external factors should be considered in the differential diagnosis.
- Published
- 1996
- Full Text
- View/download PDF
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