388 results on '"Shuxia Li"'
Search Results
352. Genetic and Environmental Dissections of Sub-Phenotypes of Metabolic Syndrome in the Chinese Population: A Twin-Based Heritability Study
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Shuxia Li, Dongfeng Zhang, Zengchang Pang, Haiping Duan, Qihua Tan, Torben A Kruse, Kaare Christensen, and Kirsten Ohm Kyvik
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Adult ,Male ,China ,Health (social science) ,Twins ,Blood Pressure ,Bivariate analysis ,Environment ,Models, Biological ,Genetic correlation ,Body Mass Index ,Correlation ,Young Adult ,Risk Factors ,Physiology (medical) ,Humans ,Medicine ,Triglycerides ,Metabolic Syndrome ,Genetics ,Univariate analysis ,business.industry ,Body Weight ,Univariate ,Middle Aged ,Heritability ,medicine.disease ,Lipids ,Phenotype ,Cholesterol ,Original Article ,Female ,Metabolic syndrome ,Factor Analysis, Statistical ,business - Abstract
Objective: We perform a comprehensive heritability study on multiple phenotypes related to metabolic syndrome using Chinese twins to assess the genetic and environmental effects in determining the variation and covariation of the phenotypes in the Chinese population. Methods: The studied sample contains 654 twins collected in the Qingdao municipality. A total of 10 phenotypes covering anthropometric measurements, plasma glucose levels, lipids, blood pressures etc. were examined. Univariate and bivariate structural equation models were fitted for assessing the genetic and environmental contributions. Results: The AE model combining additive genetic (A) and unique environmental (E) factors produced the best fit for all phenotypes except for triglyceride. Modest to high heritability estimates were obtained in univariate analysis ranging from 0.5 for total cholesterol to 0.78 for weight. The bivariate model estimated high genetic correlations between systolic and diastolic blood pressures, between total cholesterol and low density lipoprotein cholesterol, modest genetic correlations between BMI and blood pressures. No significant common environmental correlation was found between any pair of the phenotypes. Conclusions: Our results showed significant genetic contributions to the sub-phenotypes of metabolic syndrome. Although pleiotropic genetic control may exist for some physiologically similar phenotypes, our results do not support a common genetic mechanism among the phenotypes covered in our study.
- Published
- 2011
353. Computer-designed orthogonal RNA aptamers programmed to recognize Ebola virus glycoproteins
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Yue Teng, Shuxia Liu, Shan Yang, Xiaocan Guo, Yanwen Zhang, Yajun Song, and Yujun Cui
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Ebola virus ,Glycoproteins ,RNA aptamers ,Molecular dynamic ,de novo design ,Infectious and parasitic diseases ,RC109-216 ,Public aspects of medicine ,RA1-1270 - Abstract
Ebola virus (EBOV), a member of the filovirus family, is an enveloped negative-sense RNA virus that causes lethal infections in humans and primates. Thousands of people have died from the Ebola virus disease (EVD) in West Africa, and no specific antiviral medication and treatment have been approved for EVD. Although the development of an EBOV vaccine is promising, immunity to any vaccine is not immediate. Here, we computationally analysed the structure of EBOV glycoprotein GP2 (GP2EBOV) and designed RNA aptamers that recognize and inhibit it. The aptamers specifically bind to conserved arginine residues (Arg587 and Arg596) located in the C-terminal coiled-coil region of GP2EBOV. Molecular docking of the synthetic RNA aptamers with the ectodomain of GP2EBOV revealed that the optimized orthogonal RNA aptamers have strong binding affinities with the coiled-coil region of GP2EBOV. The characterized RNA aptamers may facilitate strategies to block replication of EBOV and related Filoviruses, and thus may serve as important antivirals to reduce mortality associated with these infections.
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- 2019
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354. The Urban Macro-Economic Model System
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Shuxia Li
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Ninth ,Government ,Process (engineering) ,Regional science ,Economic model ,Business ,Plan (drawing) ,Macro ,Economic forecasting ,Task (project management) - Abstract
In the Summer of 1989, the Government of Qingdao entrusted us to charge with a task, to make a Economic Model for designing the Eighth and Ninth Five-Year Plans of this city. So a research group was organized. In June of 1990 the Macro-Economic Model System of Qingdao (MEMSQ) was developed and a number of major economic indices forecasting, policy simulation, annual plan evaluations, economic structure analysis of this city were run. The modelling system was handed over to the Plan Committee of the City Government, and had been used in the process of designing the plans.
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- 1992
355. An Estimate and Discussion about the Improvement of Labour Force Quality for Industry Output Contribution in Qingdao
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Shuxia Li, Haohao Li, and Keren Sun
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Combinatorics ,Physics ,Operations research ,Production (computer science) - Abstract
Consider the Cobb-Douglas production function on the assumption of constant returns to scale $$Y = A{e^{bt}}{L^{1 - \beta }}{K^\beta }$$ (1) we can calculate the proportion of outputs increase depending on composite technical progress: $${k_1} = \tfrac{b}{{\tfrac{{\Delta Y}}{Y}}}$$ (2) the proportion of outputs increase depending on labour force: $${k_2} = \tfrac{{(1 - \beta )\tfrac{{\Delta L}}{L}}}{{\tfrac{{\Delta Y}}{Y}}}$$ (3) the proportion of outputs increase depending on fixed assets: $${k_3} = \tfrac{{\beta \tfrac{{\Delta K}}{K}}}{{\tfrac{{\Delta Y}}{Y}}}$$ (4)
- Published
- 1992
356. Gene, environment and cognitive function: a Chinese twin ageing study.
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Chunsheng Xu, Jianping Sun, Haiping Duan, Fuling Ji, Xiaocao Tian, Yaoming Zhai, Shaojie Wang, Zengchang Pang, Dongfeng Zhang, Zhongtang Zhao, Shuxia Li, Mc Gue, Matt, Hjelmborg, Jacob V. B., Christensen, Kaare, and Qihua Tan
- Abstract
Background: the genetic and environmental contributions to cognitive function in the old people have been well addressed for the Western populations using twin modelling showing moderate to high heritability. No similar study has been conducted in the world largest and rapidly ageing Chinese population living under distinct environmental condition as the Western populations. Objective: this study aims to explore the genetic and environmental impact on normal cognitive ageing in the Chinese twins. Design/setting: cognitive function was measured on 384 complete twin pairs with median age of 50 years for seven cognitive measurements including visuospatial, linguistic skills, naming, memory, attention, abstraction and orientation abilities. Data were analysed by fitting univariate and bivariate twin models to estimate the genetic and environmental components in the variance and co-variance of the cognitive assessments. Results: intra-pair correlation on cognitive measurements was low to moderate in monozygotic twins (0.23-0.41, overall 0.42) and low in dizygotic twins (0.05-0.30, overall 0.31) with the former higher than the latter for each item. Estimate for heritability was moderate for overall cognitive function (0.44, 95% CI: 0.34-0.53) and low to moderate for visuospatial, naming, attention and orientation abilities ranging from 0.28 to 0.38. No genetic contribution was estimated to linguistic skill, abstraction and memory which instead were under low to moderate control by shared environmental factors accounting for 23-33% of the total variances. In contrast, all cognitive performances showed moderate to high influences by the unique environmental factors. Conclusions: genetic factor and common family environment have a limited contribution to cognitive function in the Chinese adults. Individual unique environment is likely to play a major role in determining the levels of cognitive performance. [ABSTRACT FROM AUTHOR]
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- 2015
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357. Using a Household Juice Extractor for Introductory Cell Biology Laboratories: An Example of DNA Extraction from Onion Bulbs
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Kristen Smith, Shuxia Li, Douglas Wilson, Susan Sollars, and James P. Braselton
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Food science ,Onion bulb ,Biology ,DNA extraction ,Extractor - Published
- 1997
358. Ant Colony Optimization Algorithm-Based Disassembly Sequence Planning.
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Hongbo Shan, Shuxia Li, Jing Huang, Zhimin Gao, and Wei Li
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- 2007
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359. A New Hybrid GA/SA Algorithm for the Job Shop Scheduling Problem.
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Raidl, Günther R., Gottlieb, Jens, Chaoyong Zhang, Peigen Li, Yunqing Rao, and Shuxia Li
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Among the modern heuristic methods, simulated annealing (SA) and genetic algorithms (GA) represent powerful combinatorial optimization methods with complementary strengths and weaknesses. Borrowing from the respective advantages of the two paradigms, an effective combination of GA and SA, called Genetic Simulated Algorithm (GASA), is developed to solve the job shop scheduling problem (JSP). This new algorithm incorporates metropolis acceptance criterion into crossover operator, which could maintain the good characteristics of the previous generation and reduce the disruptive effects of genetic operators. Furthermore, we present two novel features for this algorithm to solve JSP. Firstly, a new full active schedule (FAS) based on the operation-based representation is presented to construct schedule, which can further reduce the search space. Secondly, we propose a new crossover operator, named Precedence Operation Crossover (POX), for the operation-based representation. The approach is tested on a set of standard instances and compared with other approaches. The Simulation results validate the effectiveness of the proposed algorithm. [ABSTRACT FROM AUTHOR]
- Published
- 2005
360. Three new records of aspicilioid lichens from China.
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Xuejiao Hou, Shuxia Li, and Qiang Ren
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LICHENS , *PLANT species , *SODIUM hypochlorite , *MORPHOLOGY - Abstract
As a result of our studies on the lichen family Megasporaceae, three species new to China, Aspicilia cupulifera (H.Magn.) Oxner, A. narssaquensis (Lynge) J. W. Thomson and Circinaria arida Owe-Larss., A. Nordin & Tibell are described and illustrated. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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361. Doubly-excited 1,3De resonance states of two-electron positive ions Li+ and Be2+ in Debye plasmas.
- Author
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Kar, Sabyasachi, Yang Wang, Zishi Jiang, Shuxia Li, and Ratnavelu, K.
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LITHIUM ions ,DEBYE'S theory ,WAVE functions ,EXPONENTIAL functions ,DELOCALIZATION energy - Abstract
We investigate the bound
1,3 D states and the doubly-excited1,3 De resonance states of two-electron positive ions Li+ and Be2+ by employing correlated exponential wave functions. In the framework of the stabilization method, we are able to extract three series (2pnp, 2snd, 2pnf) of ¹De resonances and two series (2pnp, 2snd) of ³De resonances below the N = 2 threshold. The1,3 De resonance parameters (resonance energies and widths) for Li+ and Be2+ along with the bound-excited 1s3d 1,3D state energies are reported for the first time as functions of the screening parameter. Accurate resonance energies and widths are also reported for Li+ and Be2+ in vacuum. For free-atomic cases, comparisons are made with the reported results and few resonance states are reported for the first time. [ABSTRACT FROM AUTHOR]- Published
- 2014
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362. LncRNA DLX6-AS1 Promotes Malignant Phenotype and Lymph Node Metastasis in Prostate Cancer by Inducing LARGE Methylation
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Zhifeng Zhao, Shuxia Liang, and Fuguang Sun
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prostate cancer ,LncRNA homeobox 6 antisense 1 ,DNA methyltransferase 1 ,like-acetylglucosaminyltransferase ,CpG island methylation ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Long non-coding RNAs (lncRNAs) have recently become recognized as crucial players in cancer cellular events including proliferation, migration, and invasion. Herein, we investigated the potential role of lncRNA DLX6-AS1 in prostate cancer cell malignant behaviors and lymph node metastasis. A differentially expressed lncRNA DLX6-AS1 and its downstream regulatory gene (LARGE) were predicted by analysis in silico. RT-qPCR and western blot analysis results demonstrated that DLX6-AS1 was highly expressed, but LARGE was poorly expressed in prostate cancer tissues and cells. The online website indicated that DLX6-AS1 negatively targeted LARGE expression, which was validated by Pearson correlation analysis and MSP. ChIP, RIP, and RNA pull-down assays further suggested that DLX6-AS1 downregulated LARGE expression through recruitment of DNMT1 to its promoter. We induced DLX6-AS1/LARGE overexpression or knockdown to examine their effects through Edu and Transwell assays, which revealed that DLX6-AS1 overexpression accelerated proliferation, invasion, and migration of prostate cancer cells, and that overexpression of LARGE rescued these effects. Tumors xenografts studies confirmed that DLX6-AS1 promoted lymph node metastasis by regulating LARGE, as evidenced by enhanced expression of MMP-9, uPAR, and cathepsin B. In summary, DLX6-AS1 stimulated prostate cancer malignant progression and lymph node metastasis by inducing DNMT1-mediated LARGE methylation, highlighting a potential therapeutic target against prostate cancer.
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- 2020
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363. Multimodal nonlinear optical microscopy improves the accuracy of early diagnosis of squamous intraepithelial neoplasia.
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Seng Khoon Teh, Wei Zheng, Shuxia Li, Dong Li, Yan Zeng, Yanqi Yang, and Jianan Y. Qua
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MICROSCOPY ,PRECANCEROUS conditions ,DIAGNOSTIC imaging research ,FLUORESCENCE ,KERATIN ,NAD (Coenzyme) ,TRYPTOPHAN - Abstract
We explore diagnostic utility of a multicolor excitation multimodal nonlinear optical (NLO) microscopy for noninvasive detection of squamous epithelial precancer in vivo. The 7,12-dimenthylbenz(a)anthracene treated hamster cheek pouch was used as an animal model of carcinogenesis. The NLO microscope system employed was equipped with the ability to collect multiple tissue endogenous NLO signals such as two-photon excited fluorescence of keratin, nicotinamide adenine dinucleotide, collagen, and tryptophan, and second harmonic generation of collagen in spectral and time domains simultaneously. A total of 34 (11 controlled and 23 treated) Golden Syrian hamsters with 62 in vivo spatially distinct measurement sites were assessed in this study. High-resolution label-free NLO images were acquired from stratum corneum, stratum granulosum-stratum basale, and stroma for all tissue measurement sites. A total of nine and eight features from 745 and 600 nm excitation wavelengths, respectively, involving tissue structural and intrinsic biochemical properties were found to contain significant diagnostic information for precancers detection (p < 0.05). Particularly, 600 nm excited tryptophan fluorescence signals emanating from stratum corneum was revealed to provide remarkable diagnostic utility. Multivariate statistical techniques confirmed the integration of diagnostically significant features from multicolor excitation wavelengths yielded improved diagnostic accuracy as compared to using the individual wavelength alone. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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364. Power assessment for genetic association study of human longevity using offspring of long-lived subjects.
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Qihua Tan, Jing Zhao, Shuxia Li, Kruse, Torben, and Christensen, Kaare
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LONGEVITY ,COMPUTER simulation ,GENE frequency ,FAMILIES ,HEREDITY ,GENOTYPE-environment interaction ,GENETIC research - Abstract
Recently, an indirect genetic association approach that compares genotype frequencies in offspring of long-lived subjects and offspring from random families has been introduced to study gene-longevity associations. Although the indirect genetic association has certain advantages over the direct association approach that compares genotype frequency between centenarians and young controls, the power has been of concern. This paper reports a power study performed on the indirect approach using computer simulation. We perform our simulation study by introducing the current Danish population life table and the proportional hazard model for generating individual lifespan. Family genotype data is generated using a genetic linkage program for given SNP allele frequency. Power is estimated by setting the type I error rate at 0.05 and by calculating the Armitage’s chi-squared test statistic for 200 replicate samples for each setting of the specified allele risk and frequency parameters under different modes of inheritance and for different sample sizes. The indirect genetic association analysis is a valid approach for studying gene-longevity association, but the sample size requirement is about 3–4 time larger than the direct approach. It also has low power in detecting non-additive effect genes. Indirect genetic association using offspring from families with both parents as nonagenarians is nearly as powerful as using offspring from families with one centenarian parent. In conclusion, the indirect design can be a good choice for studying longevity in comparison with other alternatives, when relatively large sample size is available. [ABSTRACT FROM AUTHOR]
- Published
- 2010
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365. Haplotype association analysis of human disease traits using genotype data of unrelated individuals.
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QIHUA TAN, LENE CHRISTIANSEN, KAARE CHRISTENSEN, LISE BATHUM, SHUXIA LI, JING HUA ZHAO, and TORBEN A. KRUSE
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- 2005
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366. Temperature Influence on Formability and Microstructure of AZ31B during Electric Hot Temperature-Controlled Incremental Forming
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Haoran Zhang, Xingrong Chu, Shuxia Lin, Huawei Bai, and Jiao Sun
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Magnesium alloy sheet ,electric ,incremental forming ,microstructure ,deformation behavior ,Technology ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Microscopy ,QH201-278.5 ,Descriptive and experimental mechanics ,QC120-168.85 - Abstract
The straight groove test of AZ31B magnesium alloy sheet by electric hot temperature-controlled incremental sheet forming (ISF) was conducted at different temperatures. The temperature influence on fracture depth, deformation force and strain distribution was investigated. It was found that the limit depth and major strain increased as the temperature rose and that the forming force decreased correspondingly. Furthermore, the fracture behavior changed from brittle fracture to ductile fracture. Considering the formability and surface wear comprehensively, the optimized forming temperature was determined to be 300 °C. The microstructure of the groove specimen was analyzed and the dynamic recrystallization (DRX) was considered to be the reason for the improved formability. The degree of DRX depended on the temperature and degree of deformation, which resulted in non-uniform distribution of hardness within the cross section of the groove specimen.
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- 2021
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367. Effects of Different Fertilizer Treatments on Rhizosphere Soil Microbiome Composition and Functions
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Yanan Li, Chengyu Wang, Tianye Wang, Yutao Liu, Shuxia Jia, Yunhang Gao, and Shuxia Liu
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metagenomic analysis ,rhizosphere ,soil microbiome ,microbiome function ,fertilizer ,Agriculture - Abstract
Fertilization influences the soil microbiome. However, little is known about the effects of long-term fertilization on soil microbial metabolic pathways. In this study, we investigated the soil microbiome composition and function and microbial participation in the N cycle according to the Kyoto Encyclopedia of Genes and Genomes (KEGG) and gene ontology (GO) functional annotation of different genes in a metagenomic analysis after long-term fertilization. Fertilizer application significantly changed the soil C/N ratio. Chemical fertilizer (NPK) treatment decreased soil pH, and chemical fertilizer combined with straw (NPK+S0.5) treatment increased ammonium nitrogen (NH4+-N) but decreased nitrate nitrogen (NO3−-N). NPK, NPK+S0.5 and S0.5 applications did not change the soil microbiome composition or dominant phylum but changed the relative abundances of microbiome components. Moreover, fertilizer significantly influenced metabolic processes, cellular processes and single-organism processes. Compared with a no-fertilizer treatment (CK), the NPK treatment resulted in more differentially expressed gene (DEG) pathways than the NPK+S0.5 and S0.5 treatments, and these pathways significantly correlated with soil nitrate nitrogen (NO3−-N), available phosphorus (AP) and the moisture content of soil (MC). KEGG analysis found that fertilizer application mainly affected the ribosome, photosynthesis and oxidative phosphorylation pathways. S0.5 and NPK+S0.5 increased microbial nitrogen fixation, and NPK and NPK+S0.5 decreased amoA and amoB and accelerated denitrification. Thus, organic fertilizer increased N fixation and nitrification, and inorganic N fertilizer accelerated denitrification. We found that the function of the soil microbiome under different fertilizer applications could be important for the rational application of fertilizer and for environmental and sustainable development.
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- 2020
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368. An Integrative Analysis Reveals a Central Role of P53 Activation via MDM2 in Zika Virus Infection Induced Cell Death
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Yue Teng, Shufeng Liu, Xiaocan Guo, Shuxia Liu, Yuan Jin, Tongtong He, Dehua Bi, Pei Zhang, Baihan Lin, Xiaoping An, Dan Feng, Zhiqiang Mi, and Yigang Tong
- Subjects
Zika virus ,microcephaly ,capsid protein ,P53 ,MDM2 ,cell death ,Microbiology ,QR1-502 - Abstract
Zika virus (ZIKV) infection is an emerging global threat that is suspected to be associated with fetal microcephaly. However, the molecular mechanisms underlying ZIKV disease pathogenesis in humans remain elusive. Here, we investigated the human protein interaction network associated with ZIKV infection using a systemic virology approach, and reconstructed the transcriptional regulatory network to analyze the mechanisms underlying ZIKV-elicited microcephaly pathogenesis. The bioinformatics findings in this study show that P53 is the hub of the genetic regulatory network for ZIKV-related and microcephaly-associated proteins. Importantly, these results imply that the ZIKV capsid protein interacts with mouse double-minute-2 homolog (MDM2), which is involved in the P53-mediated apoptosis pathway, activating the death of infected neural cells. We also found that synthetic mimics of the ZIKV capsid protein induced cell death in vitro and in vivo. This study provides important insight into the relationship between ZIKV infection and brain diseases.
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- 2017
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369. Anti-OSM Antibody Inhibits Tubulointerstitial Lesion in a Murine Model of Lupus Nephritis
- Author
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Qingjuan Liu, Yunxia Du, Kejun Li, Wei Zhang, Xiaojuan Feng, Jun Hao, Hongbo Li, and Shuxia Liu
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Pathology ,RB1-214 - Abstract
The purpose of this study was to investigate the role of oncostatin M (OSM) in tubulointerstitial lesion (TIL) in lupus nephritis (LN). We found that OSM was highly expressed in the renal tissue of LN mice. OSM is one of the interleukin-6 cytokine family members. In order to clarify the role and mechanism of OSM in LN, mice with LN were treated with anti-OSM antibody or isotype antibody. We evaluated the tubular epithelial-mesenchymal transdifferentiation (EMT) by detecting the E-cadherin, α-smooth muscle actin (α-SMA), and fibronectin (FN) expression. We analyzed the inflammation by observing the monocyte chemotactic factor-1 (MCP-1) and intercellular adhesion molecule (ICAM-1) expression and calculated the tubulointerstitial fibrosis area by Masson staining. The results showed that anti-OSM antibody, rather than isotype antibody, improved EMT, inflammation, and tubulointerstitial fibrosis. In addition, the signal transducer and activator of transcription (STAT) 1 and STAT3 signaling was activated by tyrosine phosphorylation in LN mouse renal tissue, indicating that the phosphorylated STAT1 (p-STAT1) and p-STAT3 were involved in kidney injury. Moreover, decreased p-STAT3 instead of p-STAT1 has been observed after anti-OSM antibody injection. Thus, we concluded that OSM is associated with TIL in lupus nephritis, which may be connected with the activation of STAT3 rather than that of STAT1.
- Published
- 2017
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370. Diagnostic value of nonlinear optical signals from collagen matrix in the detection of epithelial precancer.
- Author
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Wei Zheng, Dong Li, Shuxia Li, Yan Zeng, Yanqi Yang, and Qu, Jianan Y.
- Published
- 2011
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371. Decontamination of Arsenic in Actual Water Samples by Calcium Containing Layered Double Hydroxides from a Convenient Synthesis Method
- Author
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Hongtao Lu, Shuxia Liu, Hua Zhang, Yanling Qiu, Jianfu Zhao, and Zhiliang Zhu
- Subjects
calcium ,layered double hydroxides ,arsenic ,adsorption ,actual water sample ,Hydraulic engineering ,TC1-978 ,Water supply for domestic and industrial purposes ,TD201-500 - Abstract
A series of calcium-containing layered double hydroxides (LDHs) and calcined product (CLDH) were synthesized using a comparative simple synthesis method (without using organic solvents and with a shortened reaction time) and applied in the adsorption of arsenic in water. The adsorption performance of arsenate on these LDHs and CLDH were studied using batch tests. The effects of various factors during the adsorption process, such as pH of the solution, dosage of materials, coexisting ions, contact time, and initial arsenate concentration, were evaluated. The maximum adsorption capacity of arsenate on three materials (CaFe-CLDH, CaFe-Cl-LDH, CaFe-NO3-LDH) were 156.0 mg·g−1, 150.5 mg·g−1, and 148.0 mg·g−1, respectively. When the concentration of CaFe-CLDH was 0.5 g·L−1, the concentration of arsenate was reduced from 5000 μg·L−1 to 10 μg·L−1 after adsorption. Moreover, when the CaFe-NO3-LDH or CaFe-Cl-LDH dosage was 1.0 g·L−1, a similar decontamination result could be achieved. The synthesized CaFe-CLDH was used to treat actual contaminated water samples from a river in a mining area north of Lengshuijiang City in Hunan Province, China. After treating using CaFe-CLDH, the residual arsenic concentration of actual water samples can fully meet the requirements for arsenic in the drinking water standards of the World Health Organization and China. This indicates that synthetic CaFe-CLDH has the potential to serve as an effective adsorbent for the removal of arsenic contamination.
- Published
- 2018
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372. Additional file 5: of Epigenetic signature of preterm birth in adult twins
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Qihua Tan, Shuxia Li, Frost, Morten, Nygaard, Marianne, Soerensen, Mette, Larsen, Martin, Christensen, Kaare, and Christiansen, Lene
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3. Good health - Abstract
Table S3. CpGs under top DMRs. (PDF 71 kb)
373. Additional file 2: of Epigenetic signature of preterm birth in adult twins
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Qihua Tan, Shuxia Li, Frost, Morten, Nygaard, Marianne, Soerensen, Mette, Larsen, Martin, Christensen, Kaare, and Christiansen, Lene
- Subjects
3. Good health - Abstract
Table S1. PTB EWAS results with p value below 1%. (PDF 570 kb)
374. DNA methylation profiles of polycystic ovarian syndrome in Chinese women: A case-control study
- Author
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Shuxia Li, Hongmei Duan, Zhu, D., Ren, A., Dorte Glintborg, Marianne Andersen, Skov, V., Mads Thomassen, Kruse, Torben A., and Qihua Tan
- Abstract
As a universally common endocrinopathy in women of reproductive age, the polycystic ovarian syndrome is characterized by composite clinical phenotypes refl ecting the contributions of reproductive impact of ovarian dysfunction and metabolic abnormalities with widely varying symptoms resulting from interference of the genome with the environment through integrative biological mechanisms including epigenetics. We have performed a genome-wide DNA methylation analysis on polycystic ovarian syndrome using Illumina’s HumanMethylation450 BeadChip array. We identifi ed a substantial number of genomic sites diff erentially methylated in the whole blood of 30 PCOS patients and 30 healthy controls (52 sites, false discovery rate
375. Epigenetic signature of preterm birth in adult twins
- Author
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Qihua Tan and Shuxia Li
- Abstract
Preterm birth is a leading cause of perinatal mortality and long-term health consequences. Epigenetic mechanisms may have been at play in preterm birth survivors and these could be persistent and detrimental to health later in life. We performed a genome-wide DNA methylation profiling adult twins of premature birth to identify genomic regions under differential epigenetic regulation in 144 twins with a median age of 33 years (age range: 30-36). Association analysis detected three genomic regions annotated to the SDHAP3, TAGLN3, and GSTT1 genes on chromosomes 5, 3, and 22 (FWER: 0.01, 0.02 and 0.04) respectively. These genes display strong involvement in neurodevelopmental disorders,cancer susceptibility and premature delivery. The three identified significant regions were successfully replicated in an independent sample of twins of even older age (median age 66, range: 56-80) with similar regulatory patterns and nominal p values
376. Secular change in 13 metabolic phenotypes: A Chinese longitudinal twin study
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Shuxia Li, Zengchang Pang, Dongfeng Zhang, Haiping Duan, Qihua Tan, Jacob Hjelmborg, Kirsten Ohm Kyvik, and Kruse, Torben A.
- Subjects
Chinese ,Longitudinal Studies ,twin study ,metabolic syndrome - Abstract
Aims: The genetic and environmental influences on metabolic phenotypeshave been intensively studied by twin modeling in different populations.However, twin studies on secular change in metabolic phenotypes havebeen rare due to high expenses, losses of follow up, and long waiting timein prospective investigations. Based on Chinese twin data collected fromDanish-Chinese collaboration research, we perform twin modeling on 13metabolic phenotypes (total cholesterol; triglyceride; high density lipoprotein(HDL); low density lipoprotein (LDL); urine acid (UA); glucose; weight; bodymass index (BMI); waist and hip circumstance and ratio (WHR); systolicblood pressure (SBP); diastolic blood pressure (DBP)) measured longitudinallyin a period of 7 years in 254 middle aged Chinese twins (126 monozygotic;128 dizygotic twins). Methods: Univariate ACE, ADE models andtheir nested models were fitted to the secular changes in each of the 13phenotypes with best fitting model selected based on model performance.Age and sex were included as covariates in the models to adjust for theireffects on secular trend. Results: Variations in secular change in 3 lipids(total cholesterol; triglyceride; LDL), weight and blood pressure (SBP, DBP)have AE model as the best fitting model with low to moderate (a2: 0.25 -0.46) genetic control. Variations in secular change in the rest of the phenotypeshave CE model as the best fitting model with low to moderate (c2:0.21 - 0.55) control by shared environmental factors. Secular changes inall phenotypes are under moderate to high (e2: 0.45 - 0.79) control by uniqueenvironmental factors. Conclusions: Variations in secular change in the13 metabolic phenotypes show limited genetic control. Our results emphasizethe special importance of unique environment in determining individualchange in metabolic phenotypes in adult Chinese.
377. Additional file 2: of Epigenetic signature of preterm birth in adult twins
- Author
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Qihua Tan, Shuxia Li, Frost, Morten, Nygaard, Marianne, Soerensen, Mette, Larsen, Martin, Christensen, Kaare, and Christiansen, Lene
- Subjects
3. Good health - Abstract
Table S1. PTB EWAS results with p value below 1%. (PDF 570 kb)
378. Genome-wide linkage scan for QTL affecting BMI in Chinese twins using high density SNP markers
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Zhang, D., Shuxia Li, Pang, Z., Kruse, Torben A., Kaare Christensen, Kirsten Ohm Kyvik, and Qihua Tan
379. Bivariate analysis of blood pressure traits in Danish and Chinese twins
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Shuxia Li, Kruse, Torben A., and Kirsten Ohm Kyvik
- Subjects
blood pressure ,twin - Abstract
Studying the multiplex genetic basis of blood pressure regulation can help with elucidating the etiology of hypertension and related diseases as well as with the development of more efficient prevention and treatment strategies. This study aims at investigating the genetic and environmental backgrounds for blood pressure variation as well as for phenotype correlation between systolic and diastolic blood pressure by fitting bivariate models to Danish and Chinese twins and comparing ethnic difference between the two samples. The Danish sample consists of 756 twin pairs (309 monozygotic or MZ pairs, 447 dizygotic or DZ pairs) and Chinese sample includes a total of 325 pairs of twins (183 MZ twin pairs and 142 DZ twin pairs). Our parameter estimates revealed moderate to high additive genetic and unique environmental influences on both systolic and diastolic blood pressure and on their correlation with an overall pattern of higher genetic regulation in Danish than in Chinese twins while higher contribution by unique environment in Chinese than in Danish twins. The estimated genetic components in blood pressure and in blood pressure correlation could serve to guide new researches aiming at looking for heritable genetic variants that affect systolic and/or diastolic blood pressure. Meanwhile, the estimated high contribution to blood pressure by unique environment suggests that promoting healthy lifestyle could provide an efficient way for the control of hypertension especially in the Chinese population.
380. Identification, replication and characterization of epigenetic remodelling in the aging genome
- Author
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Shuxia Li, Lene Christiansen, Kaare Christensen, Kruse, Torben A., Paul Redmond, Marioni, Riccardo E., Deary, Lan J., and Qihua Tan
- Subjects
Epigenetics and Gene Regulation - Abstract
Background: Aging is a complex biological process that involves numerous changes at various levels through remodelling of multiple biological processes and regulatory mechanisms including epigenetics. Recent analysis of the DNA methylome has reported large numbers of epigenetic markers associated with human aging. Validation and characterization of the significant findings are necessary both for obtaining reliable results and for better describing the age-associated epigenetic modifications. Methods: Based on genome-wide DNA methylation data measured in a large collection of older individuals in the Lothian Birth Cohorts of 1921 and 1936, we performed an association study to identify age-associated CpGs and replicated the findings in two independent cohorts of Danish twins. The double-replicated CpGs were characterized by distribution over gene regions and by their location in relation to CpG islands conditional on their age-dependent patterns of methylation status. The replicated CpGs were further characterized by their involvement in gene-sets or canonical pathways to study their functional implications. Results: We identified 67,604 age-associated CpG sites reaching genome-wide significance of FWER
381. Cross-population disparity in genetic and environmental effect on endophenotypes associated with metabolic syndrome
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Qihua Tan, Shuxia Li, Pang, Z., Zhang, D., Kruse, Torben A., Kaare Christensen, and Kirsten Ohm Kyvik
382. Additional file 5: of Epigenetic signature of preterm birth in adult twins
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Qihua Tan, Shuxia Li, Frost, Morten, Nygaard, Marianne, Soerensen, Mette, Larsen, Martin, Christensen, Kaare, and Christiansen, Lene
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3. Good health - Abstract
Table S3. CpGs under top DMRs. (PDF 71 kb)
383. Adaptive Fuzzy Computed-Torque Control for Robot Manipulator with Uncertain Dynamics
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Yuan Chen, Guangying Ma, Shuxia Lin, and Jun Gao
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Electronics ,TK7800-8360 ,Electronic computers. Computer science ,QA75.5-76.95 - Abstract
To overcome the disadvantages of conventional computed-torque control and fuzzy control, and to exploit their attractive features, this paper proposes two types of adaptive control scheme combining conventional computed-torque control and different fuzzy compensators for the robust tracking control of robotic manipulators with structured and unstructured uncertainties. Fuzzy compensators based on feed-forward and feed-back are developed to compensate these uncertain dynamics. On the basis of Lyapunov stability theory, a tracking error limit is derived for the closed-loop control system and the convergence and stability of the control schemes are proved. Comparisons of their performances with conventional computed-torque controllers under the condition of these uncertainties are carried out. The validity of the two types of adaptive control scheme is shown by numerical simulations of a three-link rotary robot manipulator.
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- 2012
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384. Retrospective analysis of main and interaction effects in genetic association studies of human complex traits
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Jing Hua Zhao, Charlotte Brasch-Andersen, Torben A Kruse, Kaare Christensen, Lene Christiansen, Shuxia Li, and Qihua Tan
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Aging ,lcsh:QH426-470 ,Locus (genetics) ,Biology ,Logistic regression ,03 medical and health sciences ,Cognition ,Quantitative Trait, Heritable ,Genetics ,Humans ,Genetic Predisposition to Disease ,Genetics(clinical) ,Allele ,Categorical variable ,Genetics (clinical) ,Alleles ,030304 developmental biology ,Genetic association ,Aged ,Retrospective Studies ,0303 health sciences ,Models, Genetic ,030305 genetics & heredity ,Polytomous Rasch model ,Environmental exposure ,Environmental Exposure ,Middle Aged ,lcsh:Genetics ,Logistic Models ,Haplotypes ,Trait ,Research Article - Abstract
Background The etiology of multifactorial human diseases involves complex interactions between numerous environmental factors and alleles of many genes. Efficient statistical tools are demanded in identifying the genetic and environmental variants that affect the risk of disease development. This paper introduces a retrospective polytomous logistic regression model to measure both the main and interaction effects in genetic association studies of human discrete and continuous complex traits. In this model, combinations of genotypes at two interacting loci or of environmental exposure and genotypes at one locus are treated as nominal outcomes of which the proportions are modeled as a function of the disease trait assigning both main and interaction effects and with no assumption of normality in the trait distribution. Performance of our method in detecting interaction effect is compared with that of the case-only model. Results Results from our simulation study indicate that our retrospective model exhibits high power in capturing even relatively small effect with reasonable sample sizes. Application of our method to data from an association study on the catalase -262C/T promoter polymorphism and aging phenotypes detected significant main and interaction effects for age-group and allele T on individual's cognitive functioning and produced consistent results in estimating the interaction effect as compared with the popular case-only model. Conclusion The retrospective polytomous logistic regression model can be used as a convenient tool for assessing both main and interaction effects in genetic association studies of human multifactorial diseases involving genetic and non-genetic factors as well as categorical or continuous traits.
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385. A homeodomain-leucine zipper I transcription factor, MeHDZ14, regulates internode elongation and leaf rolling in cassava (Manihot esculenta Crantz).
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Xiaoling Yu, Xin Guo, Pingjuan Zhao, Shuxia Li, Liangping Zou, Wenbin Li, Ziyin Xu, Ming Peng, and Mengbin Ruan
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CASSAVA , *HOMEOBOX proteins , *TRANSCRIPTION factors , *PLANT growth , *CAFFEIC acid - Abstract
Drought stress impairs plant growth and other physiological functions. MeHDZ14, a homeodomainleucine zipper I transcription factor, is strongly induced by drought stress in various cassava cultivars. However, the role of MeHDZ14 in cassava growth regulation has remained unclear. Here we report that MeHDZ14 affected plant height, such that a dwarf phenotype and altered internode elongation were observed in transgenic cassava lines. MeHDZ14 was found to negatively regulate the biosynthesis of lignin. Its overexpression resulted in abaxially rolled leaves. The morphogenesis of leaf epidermal cells was inhibited by overexpression of MeHDZ14, with decreased auxin and gibberellin and increased cytokinin contents. MeHDZ14 was found to regulate many drought-responsive genes, including genes involved in cell wall synthesis and expansion. MeHDZ14 bound to the promoter of caffeic acid 3-Omethyltransferase 1 (MeCOMT1), acting as a transcriptional repressor of genes involved in cell wall development. MeHDZ14 appears to act as a negative regulator of internode elongation and epidermal cell morphogenesis during cassava leaf development. [ABSTRACT FROM AUTHOR]
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- 2023
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386. Down-regulation of MeMYB2 leads to anthocyanin accumulation and increases chilling tolerance in cassava (Manihot esculenta Crantz).
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Xin Guo, Xiaohui Yu, Chenyu Lin, Pingjuan Zhao, Bin Wang, Liangping Zou, Shuxia Li, Xiaoling Yu, Yinhua Chen, Peng Zhang, Ming Peng, and Mengbin Ruan
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- *
CASSAVA , *ANTHOCYANINS , *REACTIVE oxygen species , *CYANIDIN , *TRANSCRIPTION factors - Abstract
Chilling-induced accumulation of reactive oxygen species (ROS) is harmful to plants, which usually produce anthocyanins to scavenge ROS as protection from chilling stress. As a tropical crop, cassava is hypersensitive to chilling, but the biochemical basis of this hypersensitivity remains unclear. We previously generated MeMYB2-RNAi transgenic cassava with increased chilling tolerance. Here we report that MeMYB2-RNAi transgenic cassava accumulated less ROS but more cyanidin-3-O-glucoside than the wild type under early chilling stress. Under this stress, the anthocyanin biosynthesis pathway was more active in MeMYB2-RNAi lines than in the wild type, and several genes involved in the pathway, including MeTT8, were up-regulated by MeMYB2-RNAi in the transgenic cassava. MeMYB2 bound to the MeTT8 promoter and blocked its expression under both normal and chilling conditions, thereby inhibiting anthocyanin accumulation. MeTT8 was shown to bind to the promoter of Dihydroflavonol 4-reductase (MeDFR-2) and increased MeDFR-2 expression. MeMYB2 appears to act as an inhibitor of chilling-induced anthocyanin accumulation during the rapid response of cassava to chilling stress. [ABSTRACT FROM AUTHOR]
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- 2023
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387. Research on the spatial distribution characteristics of arable land economic quality composite grade and ecology environment in Yunnan Province, China
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Gengjie ZHANG, Chuan ZHANG, Shuxia Liu, and Honggang Zheng
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arable land ,economic quality composite grade ,distribution ,ecological environment ,Yunnan Province ,Biotechnology ,TP248.13-248.65 - Abstract
ABSTRACT Understanding the distribution characteristics of arable land in Yunnan Province is of significant importance to make scientific decisionsto use and improve the quality of arable land. In this study, the distribution characteristics of the arable land grade including 129 counties were analyzed based on the accomplishment of cultivated land classification in Yunnan Province. The results showed that the average economic quality composite grade was 2.9, in a range of 1 to 13, which means that the economic quality of arable landof Yunnan Province is relatively lower. In excellent zone, the grade ranges from 1 to 10, and the average grade is 2.4. In good zone, it ranges from 1~13, and the average grade is 3.1. In medium zone, it ranges from 1~12, and the average value is 3.2. In poor zone, it ranges from 1~11, and the average is 3. In worse zone, it ranges from 1~10, and the average is 2.2. The middle and poor arable land has the largest area, which concentrated in the middle and poor zones and dominantly influenced the average grade in the whole province. This research will serve as a reference forarable landpolicy making in the future, especiallyon apace arrangement optimization, quality improvement and ecology environment protection in Yunnan Province.
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388. Genetic Association Analysis of Human Longevity in Cohort Studies of Elderly Subjects: An Example of the PON1 Gene in the Danish 1905 Birth Cohort.
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Qihua Tan, Christiansen, Lene, Bathum, Lise, Shuxia Li, Kruse, Torben A., and Christensen, Xaare
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HUMAN genetic variation , *GENOTYPE-environment interaction , *LONGEVITY , *REGRESSION analysis , *DANES - Abstract
Although the case-control or the cross-sectional design has been popular in genetic association studies of human longevity, such a design is prone to false positive results due to sampling bias and a potential secular trend in gene-environment interactions. To avoid these problems, the cohort or follow-up study design has been recommended. With the observed individual survival information, the Cox regression model has been used for single-locus data analysis. In this article, we present a novel survival analysis model that combines population survival with individual genotype and phenotype information in assessing the genetic association with human longevity in cohort studies. By monitoring the changes in the observed genotype frequencies over the follow-up period in a birth cohort, we are able to assess the effects of the genotypes and/or haplotypes on individual survival. With the estimated parameters, genotype- and/or haplotype-specific survival and hazard functions can be calculated without any parametric assumption on the survival distribution. In addition, our model estimates haplotype frequencies in a birth cohort over the follow-up time, which is not observable in the multilocus genotype data. A computer simulation study was conducted to specifically assess the performance and power of our haplotype-based approach for given risk and frequency parameters under different sample sizes. Application of our method to paraoxonase genotype data detected a haplotype that significantly reduces carriers' hazard of death and thus reveals and stresses the important role of genetic variation in maintaining human survival at advanced ages. [ABSTRACT FROM AUTHOR]
- Published
- 2006
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