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1,155 results on '"Shi, Qinghua"'

404. ArhGAP30 promotes p53 acetylation and function in colorectal cancer

Author

Wang, Jilin, primary, Qian, Jin, additional, Hu, Ye, additional, Kong, Xuan, additional, Chen, Haoyan, additional, Shi, Qinghua, additional, Jiang, Long, additional, Wu, Chenming, additional, Zou, Weiping, additional, Chen, Yingxuan, additional, Xu, Jie, additional, and Fang, Jing-Yuan, additional

Published
2014
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415. Essential requirement of mammalian Pumiliofamily in embryonic development

Author

Lin, Kaibo, Zhang, Shikun, Shi, Qinghua, Zhu, Mengyi, Gao, Liuze, Xia, Wenjuan, Geng, Baobao, Zheng, Zimeng, and Xu, Eugene Yujun

Abstract

Loss of mouse Pum1 and Pum2 led to embryonic lethality by embryonic day 8.5. Gastrulation failure and reduced growth occurred in Pum1- and Pum2-deficient embryos. Gata6 expression increased in embryonic stem cells (ESCs) and embryos in the absence of Pum1 and Pum2. PUM1-mediated posttranscriptional regulation of Gata6 expression in ESCs is important for gastrulation.

Published
2018
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418. Griseofulvin-induced aneuploidy and meiotic delay in male mouse germ cells: detected by using conventional cytogenetics and three-color FISH

Author

Shi Qinghua, Thomas E. Schmid, and Ilse-Dore Adler

Subjects
Male, Antifungal Agents, Health, Toxicology and Mutagenesis, Aneuploidy, Biology, Griseofulvin, Andrology, Mice, Random Allocation, Meiosis, Genetics, medicine, Image Processing, Computer-Assisted, Animals, Interkinesis, Metaphase, In Situ Hybridization, Fluorescence, Chromosome Aberrations, Epididymis, medicine.diagnostic_test, Dose-Response Relationship, Drug, urogenital system, Chromosome, medicine.disease, Sperm, Spermatozoa, Microscopy, Fluorescence, Female, DNA Probes, Corn oil, Fluorescence in situ hybridization
Abstract

Griseofulvin (GF) was tested in male mouse germ cells for the induction of meiotic delay and aneuploidy. Starved mice were orally treated with 500, 1000 and 2000 mg/kg of GF in corn oil and testes were sampled 22 h later for meiotic delay analysis and chromosome counting in spermatocytes at the second meiotic metaphase (MMII). A dose-related increase in meiotic delay by dose-dependently arresting spermatocytes in first meiotic metaphase (MMI) or/and prolonging interkinesis was observed. Hyperhaploid MMII cells were not significantly increased. Sperm were sampled from the Caudae epididymes 22 days after GF-treatment of the males for three-color fluorescence in situ hybridization (FISH). The frequencies of diploidies were 0.01-0.02% in sperm of the solvent control animals and increased dose-dependently to 0.03%, 0.068% and 0.091%, respectively, for 500, 1000 and 2000 mg/kg of GF. The frequencies of disomic sperm were increased significantly above the controls in all GF-treated groups but showed no dose response. The data for individual classes of disomic sperm indicated that MII was more sensitive than MI to GF-induced non-disjunction in male mice. A comparison of the present data from male mice and literature data from female mice suggests that mouse oocytes are more sensitive than mouse spermatocytes to GF-induced meiotic delay and aneuploidy.

Published
1999

434. Overexpression of S- adenosylmethionine synthetase 1 enhances tomato callus tolerance to alkali stress through polyamine and hydrogen peroxide cross-linked networks.

Author

Gong, Biao, Wang, Xiufeng, Wei, Min, Yang, Fengjuan, Li, Yan, and Shi, Qinghua

Abstract

S- adenosylmethionine synthetase is a member of the stress-induced family genes. Our previous research indicated that overexpression of SlSAMS1 confers alkali stress tolerance to tomato seedlings. However, information regarding the alkali stress tolerance mechanism of SlSAMS1 and the cross-linked network between SlSAMS1 and downstream signal has been limited. To study how SlSAMS1 improves alkali stress tolerance, we manipulated the SlSAMS1 transgenic calluses through a pharmacological approach and found that overexpression of SlSAMS1 was positively correlated with polyamine (PA) and hydrogen peroxide (HO) accumulation leading to improve alkali stress tolerance. Additionally, the accumulation of HO in SlSAMS1 overexpression calluses depended on polyamine oxidase activity. The activities of antioxidant system, accumulation of organic acid, Na detoxification as well as alkali stress tolerance of the SlSAMS1 transgenic calluses were reversed by PA biosynthesis inhibitors, but not significantly influenced by ethylene biosynthesis inhibitors. These results suggest that overexpression of SlSAMS1 enhances alkali stress tolerance through PA and HO cross-linked networks, which provide new insight into how SlSAMS1 functions as a stress mediatory element in regulating plants tolerance to alkali stress. [ABSTRACT FROM AUTHOR]

Published
2016
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437. Measurement of the Thermal Diffusivity of Carbon Composite by Water-Heat Balance Method

Author

张先辉 Zhang Xianhui, 周雅斌 Zhou Yabin, 石庆华 Shi Qinghua, 曾捷 Zeng Jie, 曹海东 Cao Haidong, 张倩昀 Zhang Qianyun, and 李继峰 Li Jifeng

Subjects
Materials science, chemistry, Heat balance, Composite number, chemistry.chemical_element, Electrical and Electronic Engineering, Composite material, Thermal diffusivity, Carbon, Atomic and Molecular Physics, and Optics, Electronic, Optical and Magnetic Materials
Published
2013

438. The limits of consumption of food in China in 2030

Author

Luyten, J.C., Shi Qinghua, and Penning de Vries, F.W.T.

Subjects
Research Institute for Agrobiology and Soil Fertility, Life Science, Instituut voor Agrobiologisch en Bodemvruchtbaarheidsonderzoek
Published
1996

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