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190 results on '"Shen, Z. Q."'

151. Synthesis and characterization of macroporous silica modified with optically active poly[ N-(oxazolinylphenyl)acrylamide] derivatives for potential application as chiral stationary phases.

Author

Tian, Y., Lu, W., Che, Y., Shen, L. B., Jiang, L. M., and Shen, Z. Q.

Subjects
ACRYLAMIDE, SILICA, CHIRALITY, POLYMERS, CHROMATOGRAPHIC analysis, MOLECULAR recognition
Abstract

The article discusses the results of a study on the preparation and characteristics of poly(N-(oxazolinylphenyl)acrylamide] derivatives modified with macroporous silica for use as chiral stationary phases (CSP). The authors revealed that CSP showed enhanced chromatographic performances than brush-type analogs produced by the alternative grafting-from approach. The study also noted that polymer derivatives bonded with silica have excellent enantioselectivity property.

Published
2010
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152. TWILIGHT CITY -- A VIRTUAL ENVIRONMENT FOR MOUT.

Author

Zhou, S. P., Ting, S.-P., Shen, Z. Q., and Luo, L. B.

Subjects
VIRTUAL reality, MILITARY education, MILITARY science, SIMULATION methods & models, WAR games
Abstract

We describe our work on Twilight City, a virtual training environment for Military Operations on Urbanized Terrain (MOUT). MOUT are often characterized by building-to-building, room-to-room, and person-to-person close combat, therefore the virtual training environment for MOUT requires high fidelity in 3D graphics and realistic behaviors of various objects. Twilight City is constructed on a commercial multi-player first-person shooter (FPS) game engine, the Unreal Tournament (UT). Various modifications to the UT game engine have been made to incorporate various aspects in real MOUT scenarios. Case studies show that the AI bots are able to demonstrate some human-like tactical behavior. Human factor tests are conducted to evaluate the performance of Twilight City. The results demonstrate the effectiveness of Twilight City as an urban warfare simulation environment. The lessons learned from these experiments are also discussed which provide directions for future improvement. [ABSTRACT FROM AUTHOR]

Published
2008
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165. White Paper on East Asian Vision for mm/submm VLBI: Toward Black Hole Astrophysics down to Angular Resolution of 1~R$_{S}$

Author

Asada, K., Kino, M., Honma, M., Hirota, T., Lu, R. -S, Inoue, M., Sohn, B. -W, Shen, Z. -Q, Ho, P. T. P., Kazunori Akiyama, Algaba, J-C, An, T., Bower, G., Byun, D-Y, Dodson, R., Doi, A., Edwards, P. G., Fujisawa, K., Gu, M-F, Hada, K., Hagiwara, Y., Jaroenjittichai, P., Jung, T., Kawashima, T., Koyama, S., Lee, S-S, Matsushita, S., Nagai, H., Nakamura, M., Niinuma, K., Phillips, C., Park, J-H, Pu, H-Y, Ro, H-W, Stevens, J., Trippe, S., Wajima, K., and Zhao, G-Y

Subjects
High Energy Astrophysical Phenomena (astro-ph.HE), FOS: Physical sciences, Astrophysics - High Energy Astrophysical Phenomena
Abstract

This White Paper details the intentions and plans of the East Asian Very Long Baseline Interferometry (VLBI) community for pushing the frontiers of millimeter/submillimeter VLBI. To this end, we shall endeavor to actively promote coordinated efforts in the East Asia region. Our goal is to establish firm collaborations among the East Asia VLBI community in partnership with related institutes in North America and Europe and to expand existing global mm/submm VLBI arrays for (a) exploring the vicinity of black holes with an ultimate angular resolution down to 1~R$_{S}$ (Schwarzschild radius) and (b) investigating the dynamics of circumstellar gas in star-forming regions and late-type stars, and circumnuclear gas around active galactic nuclei (AGNs). In the first half of this White Paper, we highlight scientific accomplishments of the East Asia (EA) VLBI community. Various VLBI research results on M87, Sgr A*, blazars, narrow-line Seyfert~1 galaxies, and compact symmetric objects are described, and future visions of our VLBI science are briefly presented. Maser science of star formation, stellar evolution, and physics of accretion disks around AGNs are also discussed. A new vision for conducting multi-transition maser studies using mm/submm VLBI together with the Atacama Large Millimeter/Submillimeter Array (ALMA) is described. In the second half of this White Paper, we describe the EA community's vision for using mm/submm VLBI arrays in the framework or extended version of the Event Horizon Telescope (EHT) and the Global Millimeter VLBI Array (GMVA). The accomplishment of the aforementioned goal will maximize the overall scientific outcomes of mm/submm VLBI in the world., Comment: 93 pages, 54 figures. White Paper from East Asia VLBI community

170. Measurement of the cosmic ray proton spectrum from 40 GeV to 100 TeV with the DAMPE satellite

Author

Chi Wang, Y. Z. Gong, Yujuan Liu, Kai-Kai Duan, Yaohui Zhang, L. G. Wang, Dong Ya Guo, Cihang Luo, X. Y. Peng, Jie Liu, Guangshun Huang, Zhi-Yu Sun, S. Wang, R. R. Fan, Maria Ionica, Jie Kong, Peng-Xiong Ma, Zhi Hui Xu, Xiaoyuan Huang, Yu-Sa Wang, N. H. Liao, L. Feng, Michael Ma, H. Liu, X. Y. Ma, Z. X. Dong, Dingsong Wu, Jun-jun Guo, Niu Xiaoyang, A. D'Amone, K. Gong, S. C. Wen, I. De Mitri, P. Azzarello, Min Gao, Chengrui Zhou, Shengxia Zhang, Shumei Wu, Mn Mazziotta, G. Z. Shang, K. Xi, Xian-Min Jin, F. Loparco, Xin-Fu Zhao, Z. Z. Xu, Y. Y. Huang, Shuang Xue Han, X. L. Wang, Zhongjie Yang, Y. H. Yu, G. Marsella, Zhao-Min Wang, Jinglai Duan, Andrii Tykhonov, S. B. Liu, Y. Zhang, Meng Su, Q. An, Y. F. Dong, C. Q. Feng, Xiulian Pan, Ju-Xian Song, Peidong Yang, W. Li, Y. M. Hu, S.X. Li, S. Y. Ma, H. T. Xu, Jindong Zhang, Z. Q. Xia, Yali Zhou, Jialong Chen, J. Z. Wang, X. X. Li, H. Su, M. S. Cai, Jian Wu, X. J. Bi, Haiqiong Wang, Yifan Yang, Tianxiao Ma, F. J. Gan, Donghong Chen, J. J. Zang, Hao Ting Dai, Huaguang Wang, Zhoubin Zhang, P. Bernardini, Z.-Q. Shen, F. Gargano, H. S. Chen, Manyu Ding, Y. F. Liang, R. Qiao, D. Droz, Chuan Yue, W. X. Peng, Y. F. Wei, Shi-Jun Lei, Q. Yuan, Y. J. Zhang, P. Fusco, Yun-Zhi Zhang, A. Surdo, YM Liang, Jiang Chang, J. J. Wei, Lihui Wu, D. Mo, Y. Li, Giacinto Donvito, A. De Benedittis, Wangli Chen, Yang Haibo, Quan Wang, R. Asfandiyarov, M. Di Santo, J. Y. Zhang, Xi Zhu, J. N. Rao, D. M. Wei, Zongye Zhang, Hong Yun Zhao, Yu-Xuan Zhu, D. D'Urso, Hu-Rong Yao, S. Vitillo, Yen-Po Wang, Yugang Zhang, M. Y. Cui, M. M. Salinas, Fang Fang, Wei Liu, T. S. Cui, Huan Zhao, Z. Xu, X. J. Teng, Tie-Kuang Dong, W. H. Shen, Z. T. Shen, Shanta M. Zimmer, Xian Qiang Li, Xin Wu, C. Liu, Y. F. Wang, V. Gallo, W. Zhang, Wei Jiang, Yuqing Fan, Fengtao Zhang, G. F. Xue, Pengchao Zhang, Xiangpeng Guo, Xixian Wang, An Q., Asfandiyarov R., Azzarello P., Bernardini P., Bi X. J., Cai M. S., Chang J., Chen D. Y., Chen H. F., Chen J. L., Chen W., Cui M. Y., Cui T. S., Dai H. T., D'Amone A., De Benedittis A., De Mitri I., Di Santo M., Ding M., Dong T. K., Dong Y. F., Dong Z. X., Donvito G., Droz D., Duan J. L., Duan K. K., D'Urso D., Fan R. R., Fan Y. Z., Fang F., Feng C. Q., Feng L., Fusco P., Gallo V., Gan F. J., Gao M., Gargano F., Gong K., Gong Y. Z., Guo D. Y., Guo J. H., Guo X. L., Han S. X., Hu Y. M., Huang G. S., Huang X. Y., Huang Y. Y., Ionica M., Jiang W., Jin X., Kong J., Lei S. J., Li S., Li W. L., Li X., Li X. Q., Li Y., Liang Y. F., Liang Y. M., Liao N. H., Liu C. M., Liu H., Liu J., Liu S. B., Liu W. Q., Liu Y., Loparco F., Luo C. N., Ma M., Ma P. X., Ma S. Y., Ma T., Ma X. Y., Marsella G., Mazziotta M. N., Mo D., Niu X. Y., Pan X., Peng W. X., Peng X. Y., Qiao R., Rao J. N., Salinas M. M., Shang G. Z., Shen W. H., Shen Z. Q., Shen Z. T., Song J. X., Su H., Su M., Sun Z. Y., Surdo A., Teng X. J., Tykhonov A., Vitillo S., Wang C., Wang H., Wang H. Y., Wang J. Z., Wang L. G., Wang Q., Wang S., Wang X. H., Wang X. L., Wang Y. F., Wang Y. P., Wang Y. Z., Wang Z. M., Wei D. M., Wei J. J., Wei Y. F., Wen S. C., Wu D., Wu J., Wu L. B., Wu S. S., Wu X., Xi K., Xia Z. Q., Xu H. T., Xu Z. H., Xu Z. L., Xu Z. Z., Xue G. F., Yang H. B., Yang P., Yang Y. Q., Yang Z. L., Yao H. J., Yu Y. H., Yuan Q., Yue C., Zang J. J., Zhang F., Zhang J. Y., Zhang J. Z., Zhang P. F., Zhang S. X., Zhang W. Z., Zhang Y., Zhang Y. J., Zhang Y. L., Zhang Y. P., Zhang Y. Q., Zhang Z., Zhang Z. Y., Zhao H., Zhao H. Y., Zhao X. F., Zhou C. Y., Zhou Y., Zhu X., Zhu Y., Zimmer S., An, Q., Asfandiyarov, R., Azzarello, P., Bernardini, P., Bi, X. J., Cai, M. S., Chang, J., Chen, D. Y., Chen, H. F., Chen, J. L., Chen, W., Cui, M. Y., Cui, T. S., Dai, H. T., D'Amone, A., De Benedittis, A., De Mitri, I., Di Santo, M., Ding, M., Dong, T. K., Dong, Y. F., Dong, Z. X., Donvito, G., Droz, D., Duan, J. L., Duan, K. K., D'Urso, D., Fan, R. R., Fan, Y. Z., Fang, F., Feng, C. Q., Feng, L., Fusco, P., Gallo, V., Gan, F. J., Gao, M., Gargano, F., Gong, K., Gong, Y. Z., Guo, D. Y., Guo, J. H., Guo, X. L., Han, S. X., Hu, Y. M., Huang, G. S., Huang, X. Y., Huang, Y. Y., Ionica, M., Jiang, W., Jin, X., Kong, J., Lei, S. J., Li, S., Li, W. L., Li, X., Li, X. Q., Li, Y., Liang, Y. F., Liang, Y. M., Liao, N. H., Liu, C. M., Liu, H., Liu, J., Liu, S. B., Liu, W. Q., Liu, Y., Loparco, F., Luo, C. N., Ma, M., Ma, P. X., Ma, S. Y., Ma, T., Ma, X. Y., Marsella, G., Mazziotta, M. N., Mo, D., Niu, X. Y., Pan, X., Peng, W. X., Peng, X. Y., Qiao, R., Rao, J. N., Salinas, M. M., Shang, G. Z., Shen, W. H., Shen, Z. Q., Shen, Z. T., Song, J. X., Su, H., Su, M., Sun, Z. Y., Surdo, A., Teng, X. J., Tykhonov, A., Vitillo, S., Wang, C., Wang, H., Wang, H. Y., Wang, J. Z., Wang, L. G., Wang, Q., Wang, S., Wang, X. H., Wang, X. L., Wang, Y. F., Wang, Y. P., Wang, Y. Z., Wang, Z. M., Wei, D. M., Wei, J. J., Wei, Y. F., Wen, S. C., Wu, D., Wu, J., Wu, L. B., Wu, S. S., Wu, X., Xi, K., Xia, Z. Q., Xu, H. T., Xu, Z. H., Xu, Z. L., Xu, Z. Z., Xue, G. F., Yang, H. B., Yang, P., Yang, Y. Q., Yang, Z. L., Yao, H. J., Yu, Y. H., Yuan, Q., Yue, C., Zang, J. J., Zhang, F., Zhang, J. Y., Zhang, J. Z., Zhang, P. F., Zhang, S. X., Zhang, W. Z., Zhang, Y., Zhang, Y. J., Zhang, Y. L., Zhang, Y. P., Zhang, Y. Q., Zhang, Z., Zhang, Z. Y., Zhao, H., Zhao, H. Y., Zhao, X. F., Zhou, C. Y., Zhou, Y., Zhu, X., Zhu, Y., and Zimmer, S.

Subjects
dark matter, cosmic rays, space, Proton, Milky Way, Astrophysics::High Energy Astrophysical Phenomena, Dark matter, FOS: Physical sciences, Cosmic ray, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, Kinetic energy, 01 natural sciences, 0103 physical sciences, 010306 general physics, Nuclear Experiment, Research Articles, Physics, High Energy Astrophysical Phenomena (astro-ph.HE), Spectral index, Multidisciplinary, 010308 nuclear & particles physics, High Energy Physics::Phenomenology, Settore FIS/01 - Fisica Sperimentale, SciAdv r-articles, Physics::Accelerator Physics, High Energy Physics::Experiment, Astrophysics - High Energy Astrophysical Phenomena, Research Article
Abstract

DAMPE satellite has directly measured the cosmic ray proton spectrum from 40 GeV to 100 TeV and revealed a new feature at about 13.6 TeV., The precise measurement of the spectrum of protons, the most abundant component of the cosmic radiation, is necessary to understand the source and acceleration of cosmic rays in the Milky Way. This work reports the measurement of the cosmic ray proton fluxes with kinetic energies from 40 GeV to 100 TeV, with 2 1/2 years of data recorded by the DArk Matter Particle Explorer (DAMPE). This is the first time that an experiment directly measures the cosmic ray protons up to ~100 TeV with high statistics. The measured spectrum confirms the spectral hardening at ~300 GeV found by previous experiments and reveals a softening at ~13.6 TeV, with the spectral index changing from ~2.60 to ~2.85. Our result suggests the existence of a new spectral feature of cosmic rays at energies lower than the so-called knee and sheds new light on the origin of Galactic cosmic rays.

Published
2019

171. The on-orbit calibration of DArk Matter Particle Explorer

Author

Chang Qing Feng, A. D'Amone, X.Q. Ma, K. Gong, D. Mo, R. Asfandiyarov, G. Ambrosi, Y. M. Hu, Peng-Xiong Ma, Xun Feng Zhao, Zhi Hui Xu, Jinglai Duan, Tianxiao Ma, G. Z. Shang, H. T. Xu, C. Liu, X. Y. Ma, M. Y. Cui, S. C. Wen, Chenchen Wang, J. J. Zang, Deng Yi Chen, Xixian Wang, M. M. Salinas, Niu Xiaoyang, Yaping Wang, Shanta M. Zimmer, J. N. Rao, Haiqiong Wang, Da Ming Wei, Z. Y. Sun, Hao Ting Dai, V. Gallo, Q. An, Peidong Yang, Honglong Wang, D. D’Urso, Yuan Zhu Wang, Xiulian Pan, W. Zhang, I. De Mitri, H. Liu, Yang Haibo, Wei Liang Li, D.L. Zhang, H. S. Chen, Min Gao, Li Bo Wu, A. De Benedittis, Wangli Chen, Xi Zhu, Shuyao Li, X.B. Tian, Paolo Bernardini, J.N. Dong, Sha Wu, Y. Q. Zhang, Hu-Rong Yao, Kai-Kai Duan, Y. F. Wei, Jin Chang, Jiangtao Guo, F. J. Gan, S. Y. Ma, Wei Jiang, Z. Q. Xia, Yifan Yang, L. G. Wang, P. Azzarello, Y. J. Zhang, F. Gargano, Zhenyu Zhang, Maria Ionica, Jie Kong, Y. F. Liang, Yali Zhou, Jing Xing Song, M. Di Santo, Xin Wu, Y. F. Wang, R. R. Fan, R. Qiao, M. Caragiulo, Yuqing Fan, N. H. Liao, Jindan Zhang, Qian Wang, Y.L. Xin, Jie Liu, Zhoubin Zhang, Y. H. Yu, Zhao-Qiang Shen, T. S. Cui, Zhao-Min Wang, Yun Long Zhang, Yao Ming Liang, G. F. Xue, Shengxia Zhang, Zhongjie Yang, J. J. Wei, Z. Xu, Dan Jiang, F. Loparco, Laiyu Zhang, S. Vitillo, X. L. Wang, Wei Liu, Y. Zhang, Yongxiang Liu, J.B. Zhang, J. L. Chen, Qing Yuan, Meng Su, Z.Z. Xu, G. Marsella, Andrii Tykhonov, S. Wang, X. J. Teng, Tie-Kuang Dong, M. M. Ma, Zhang Yalan, Shi-Jun Lei, D. Droz, Fengtao Zhang, Huan Zhao, S. B. Liu, M. N. Mazziotta, H. Su, A. Surdo, Jin Zhou Wang, S. Garrappa, W. H. Shen, Yinlian Zhu, Z. T. Shen, Pengchao Zhang, Guang Shun Huang, Fang Fang, X. X. Li, Hong Yun Zhao, M. S. Cai, W. X. Peng, Y. Li, Y. Z. Gong, Z. X. Dong, Chang Yi Zhou, X. Y. Peng, Lingyan Feng, K. Xi, Jindong Zhang, Di Wu, Jian Wu, Chuan Yue, Y. Y. Huang, P. Fusco, Y. F. Dong, Shan-Shan Gao, Manyu Ding, Xian-Min Jin, Ambrosi, G., An, Q., Asfandiyarov, R., Azzarello, P., Bernardini, P., Cai, M. S., Caragiulo, M., Chang, J., Chen, D. Y., Chen, H. F., Chen, J. L., Chen, W., Cui, M. Y., Cui, T. S., Dai, H. T., D'Amone, A., Benedittis, De, Mitri, De, I., Ding, Di Santo, M., Dong, J. N., Dong, T. K., Dong, Y. F., Dong, Z. X., Droz, D., Duan, K. K., Duan, J. L., D'Urso, D., Fan, R. R., Fan, Y. Z., Iemail, Author, Fang, F., Feng, C. Q., Feng, L., Fusco, P., Gallo, V., Gan, F., Gao, M., Gao, S. S., Gargano, F., Garrappa, S., Gong, K., Gong, Y. Z., Guo, J. H., Email Author, Hu, Y. M., Huang, G. S., Huang, Y. Y., Ionica, M., Jiang, D., Jiang, W., Jin, X., Kong, J., Lei, S. J., Li, S., Li, X., Li, W. L., Li, Y., Liang, Y. F., Liang, Y. M., Liao, N. H., Liu, C. M., Liu, H., Liu, J., Liu, S. B., Liu, W. Q., Liu, Y., Loparco, F., Ma, M., Ma, P. X., Ma, S. Y., Ma, T., Ma, X. Q., Ma, X. Y., Marsella, G., Mazziotta, M. N., Mo, D., Niu, X. Y., Pan, X, Peng, X. Y., Peng, W. X., Qiao, R., Rao, J. N., Salinas, M. M., Shang, G. Z., Shen, W. H., Shen, Z. Q., Shen, Z. T., Song, J. X., Su, H., Su, M., Sun, Z. Y., Surdo, A., Teng, X. J., Tian, X. B., Tykhonov, A., Vitillo, S., Wang, C., Wang, H., Wang, H. Y., Wang, J. Z., Wang, L. G., Wang, Q., Wang, S., Wang, X. H., Wang, X. L., Wang, Y. F., Wang, Y. P., Wang, Y. Z., Wang, Z. M., Wen, S. C., Wei, D. M., Wei J. J., A, Wei Y. F., C, Wu D., J, Wu J., A, H, Wu, L. B., c Wu, S. S., k Wu, X., d Xi, K., j Xia, Z. Q., a h, Xin Y. L., A, Xu H. T., K, Xu Z. H., A, H, Xu, Z. L., a Xu, Z. Z., a Xue, G. F., k Yang, H. B., j Yang, P., j Yang, Y. Q., j Yang, Z. L., j Yao, H. J., j Yu, Y. H., j Yuan, Q., a h, Yue C., A, Zang J. J., A, Zhang D. L., C, Zhang F., M, Zhang J. B., C, Zhang J. Y., M, Zhang J. Z., J, Zhang L., A, I, Zhang, P. F., a Zhang, S. X., j Zhang, W. Z., k Zhang, Y., a i, Zhang Y. J., J, Zhang Y. Q., A, Y. L., c Zhang, Y. P., j Zhang, Z., a Zhang, Z. Y., c Zhao, H., m Zhao, H. Y., j Zhao, X. F., k Zhou, C. Y., k Zhou, Y., j Zhu, X., c Zhu, Y., k Zimmer, Ambrosi G., An Q., Asfandiyarov R., Azzarello P., Bernardini P., Cai M. S., Caragiulo M., Chang J., Chen D. Y., Chen H. F., Chen J. L., Chen W., Cui M. Y., Cui T. S., Dai H. T., D'Amone A., De Beneditti, De Mitri, I. Ding, Dong J. N., Dong T. K., Dong Y. F., Dong Z. X., Droz D., Duan K. K., Duan J. L., D'Urso D., Fan R. R., Fan Y. Z., iEmail Author, Fang F., Feng C. Q., Feng L., Fusco P., Gallo V., Gan F., Gao M., Gao S. S., Gargano F., Garrappa S., Gong K., Gong Y. Z., J. H. Email Author, Hu Y. M., Huang G. S., Huang Y. Y., Ionica M., Jiang D., Jiang W., Jin X., Kong J., Lei S. J., Li S., Li X., Li W. L., Li Y., Liang Y. F., Liang Y. M., Liao N. H., Liu C. M., Liu H., Liu J., Liu S. B., Liu W. Q., Liu Y., Loparco F., Ma M., Ma P. X., Ma S. Y., Ma T., Ma X. Q., Ma X. Y., Marsella G., Mazziotta M. N., Mo D., Niu X. Y., Pan X, Peng X. Y., Peng W. X., Qiao R., Rao J. N., Salinas M. M., Shang G. Z., Shen W. H., Shen Z. Q., Shen Z. T., Song J. X., Su H., Su M., Sun Z. Y., Surdo A., Teng X. J., Tian X. B., Tykhonov A., Vitillo S., Wang C., Wang H., Wang H. Y., Wang J. Z., Wang L. G., Wang Q., Wang S., Wang X. H., Wang X. L., Wang Y. F., Wang Y. P., Wang Y. Z., Wang Z. M., Wen S. C., Wei D. M., Wei J. J. a, Wei Y. F. c, Wu D. j, Wu J. a, h Wu, L. B. c Wu, S. S. k Wu, X. d Xi, K. j Xia, Z. Q. a h, Xin Y. L. a, Xu H. T. k, Xu Z. H. a, h Xu, Z. L. a Xu, Z. Z. a Xue, G. F. k Yang, H. B. j Yang, P. j Yang, Y. Q. j Yang, Z. L. j Yao, H. J. j Yu, Y. H. j Yuan, Q. a h, Yue C. a, Zang J. J. a, Zhang D. L. c, Zhang F. m, Zhang J. B. c, Zhang J. Y. m, Zhang J. Z. j, Zhang L. a, i Zhang, P. F. a Zhang, S. X. j Zhang, W. Z. k Zhang, Y. a i, Zhang Y. J. j, Zhang Y. Q. a, Y. L. c Zhang, Y. P. j Zhang, Z. a Zhang, Z. Y. c Zhao, H. m Zhao, H. Y. j Zhao, X. F. k Zhou, C. Y. k Zhou, Y. j Zhu, X. c Zhu, and Y. k Zimmer

Subjects
Physics::Instrumentation and Detectors, Astrophysics::High Energy Astrophysical Phenomena, Dark matter, FOS: Physical sciences, Cosmic ray, Scintillator, 01 natural sciences, High Energy Physics - Experiment, High Energy Physics - Experiment (hep-ex), 0103 physical sciences, Neutron detection, Dark Matter, Instrumentation and Methods for Astrophysics (astro-ph.IM), 010303 astronomy & astrophysics, High Energy Astrophysical Phenomena (astro-ph.HE), Physics, Calorimeter (particle physics), 010308 nuclear & particles physics, Detector, Settore FIS/01 - Fisica Sperimentale, Gamma ray, Astronomy, Astronomy and Astrophysics, Cosmic Rays, South Atlantic Anomaly, High Energy Physics::Experiment, Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - High Energy Astrophysical Phenomena
Abstract

The DArk Matter Particle Explorer (DAMPE), a satellite-based cosmic ray and gamma-ray detector, was launched on December 17, 2015, and began its on-orbit operation on December 24, 2015. In this work we document the on-orbit calibration procedures used by DAMPE and report the calibration results of the Plastic Scintillator strip Detector (PSD), the Silicon-Tungsten tracKer-converter (STK), the BGO imaging calorimeter (BGO), and the Neutron Detector (NUD). The results are obtained using Galactic cosmic rays, bright known GeV gamma-ray sources, and charge injection into the front-end electronics of each sub-detector. The determination of the boundary of the South Atlantic Anomaly (SAA), the measurement of the live time, and the alignments of the detectors are also introduced. The calibration results demonstrate the stability of the detectors in almost two years of the on-orbit operation.

Published
2019

172. Genome-wide association analysis identifies the genetic basis of fat deposition in the tails of sheep ( Ovis aries).

Author

Xu, S.‐S., Ren, X., Yang, G.‐L., Xie, X.‐L., Zhao, Y.‐X., Zhang, M., Shen, Z.‐Q., Ren, Y.‐L., Gao, L., Shen, M., Kantanen, J., and Li, M.‐H.

Subjects
*SHEEP genetics, *TAILS, *SINGLE nucleotide polymorphisms, *GENOTYPES, *PHENOTYPES, *X chromosome
Abstract

Fat-tailed sheep ( Ovis aries) can survive in harsh environments and satisfy human's intake of dietary fat. However, the animals require more feed, which increases the cost of farming. Thus, most farmers currently prefer thin-tailed, short-tailed or docked sheep. To date, the molecular mechanism of the formation of fat tails in sheep has not been completely elucidated. Here, we conducted a genome-wide association study using phenotypes and genotypes (the Ovine Infinium HD SNP BeadChip genotype data) of two breeds of contrasting tail types (78 Small-tailed and 78 Large-tailed Han sheep breeds) to identify functional genes and variants associated with fat deposition. We identified four significantly (rs416433540, rs409848439, rs408118325 and rs402128848) and three approximately associated autosomal SNPs (rs401248376, rs402445895 and rs416201901). Gene annotation indicated that the surrounding genes ( CREB1, STEAP4, CTBP1 and RIP140, also known as NRIP1) function in lipid storage or fat cell regulation. Furthermore, through an X-chromosome-wide association analysis, we detected significantly associated SNPs in the OARX: 88-89 Mb region, which could be a strong candidate genomic region for fat deposition in tails of sheep. Our results represent a new genomic resource for sheep genetics and breeding. In addition, the findings provide novel insights into genetic mechanisms of fat deposition in the tail of sheep and other mammals. [ABSTRACT FROM AUTHOR]

Published
2017
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173. A genome-wide association study reveals candidate genes for the supernumerary nipple phenotype in sheep ( Ovis aries).

Author

Peng, W.‐F., Xu, S.‐S., Ren, X., Lv, F.‐H., Xie, X.‐L., Zhao, Y.‐X., Zhang, M., Shen, Z.‐Q., Ren, Y.‐L., Gao, L., Shen, M., Kantanen, J., and Li, M.‐H.

Subjects
*SHEEP genetics, *NIPPLE (Anatomy), *PHENOTYPES, *HAPLOTYPES, *GENE ontology, *SINGLE nucleotide polymorphisms, *SHEEP breeding
Abstract

Genome-wide association studies ( GWASs) have been widely applied in livestock to identify genes associated with traits of economic interest. Here, we conducted the first GWAS of the supernumerary nipple phenotype in Wadi sheep, a native Chinese sheep breed, based on Ovine Infinium HD SNP BeadChip genotypes in a total of 144 ewes (75 cases with four teats, including two normal and two supernumerary teats, and 69 control cases with two teats). We detected 63 significant SNPs at the chromosome-wise threshold. Additionally, one candidate region (chr1: 170.723-170.734 Mb) was identified by haplotype-based association tests, with one SNP (rs413490006) surrounding functional genes BBX and CD47 on chromosome 1 being commonly identified as significant by the two mentioned analyses. Moreover, Gene Ontology enrichment for the significant SNPs identified by the GWAS analysis was functionally clustered into the categories of receptor activity and synaptic membrane. In addition, pathway mapping revealed four promising pathways (Wnt, oxytocin, MAPK and axon guidance) involved in the development of the supernumerary nipple phenotype. Our results provide novel and important insights into the genetic mechanisms underlying the phenotype of supernumerary nipples in mammals, including humans. These findings may be useful for future breeding and genetics in sheep and other livestock. [ABSTRACT FROM AUTHOR]

Published
2017
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174. Traditional Chinese Medicine in the Treatment of Reproductive Disorders of Large Animals in Asia.

Author

Zuo, Z. H., Zhang, T. Y., Chu, J., Zhang, Q., Guo, Y. X., Shen, Z. Q., and He, C.

Subjects
*CHINESE medicine, *VETERINARY medicine, *GENITAL diseases, *HOMEOSTASIS, *THERAPEUTICS
Abstract

Reproductive diseases have been a great threat in large animal herds. Before induction of western medicines, traditional Chinese medicine (TCM) that is based on the use of herbal medicine, acupuncture, massage and other forms of therapy has been practiced in China for thousands of years. The foundational text of Chinese medicine dated back to 5th century to 3rd century BCE, humans in China began developing the TCM therapy by maintaining normal homeostasis and body functions. Traditional Chinese medicine prophylaxis is a very different strategy from that of the western medicine, targeting the balance of the diseased animals as compared to the single lesion. Traditional Chinese medicine was also applied to cure ruminant's reproductive disorders such as infertility, abortion and retained placenta. With the increasing concerns of the antibiotic resistance and drug abuse happened, TCM has acquired re-recognition as compared to western medicines due to eco-friendly consumer-driven developments and less residue in food chains. More importantly, a growing number of active substances or extracts with the reliable efficacy are being identified, meanwhile, the quality control measures are satisfied in the large-scale production already. However, few TCM is recognized to be used internationally as the popular human medication. Even less TCM is prescribed legally to animal industry due to poor understanding TCM philosophy and lack of the right guidelines of the registration. This summary aims to elucidate the TCM application in the treatment of the reproductive disorder in large animals and offer alternative strategies for prophylaxis. [ABSTRACT FROM AUTHOR]

Published
2016

175. Measurement of the Cosmic Ray Helium Energy Spectrum from 70 GeV to 80 TeV with the DAMPE Space Mission

Author

Fengtao Zhang, Y. F. Wang, Y. Y. Huang, Xiangpeng Guo, Jinfei Wu, D. Droz, J. N. Rao, Jinglai Duan, Yang Haibo, C. Liu, D. M. Wei, Zongye Zhang, X. Y. Ma, P. Azzarello, P. Fusco, Z. Y. Sun, Niu Xiaoyang, I. De Mitri, W. Zhang, Cihang Luo, C. Q. Feng, Yu Xing Cui, X. X. Li, M. S. Cai, Z.-Q. Shen, G. Marsella, X. L. Wang, S. Wang, F. Loparco, Guan Wen Yuan, Y. F. Wei, Jin Chang, Y. J. Zhang, Giacinto Donvito, W. X. Peng, J. L. Chen, Q. An, S. B. Liu, S. C. Wen, F. Gargano, Xiulian Pan, Y. Z. Gong, Cang Zhao, Yuqing Fan, T. S. Cui, H. T. Xu, A. De Benedittis, E. Catanzani, M. M. Salinas, Y. H. Yu, Zhao-Min Wang, Yun Long Zhang, Andrii Tykhonov, Wei Liu, Dingsong Wu, Zhenyu Zhang, Yifan Yang, G. F. Xue, Fang Fang, Pengtao Yang, M. Di Santo, R. Qiao, Yaohui Zhang, Xian Qiang Li, X. J. Bi, Chuan Yue, Min Gao, Z. Q. Xia, Shumei Wu, X. Y. Peng, M. M. Ma, Wenhan Jiang, J. Z. Wang, F. C. T. Barbato, M. Stolpovskiy, Hengchang Liu, F. Alemanno, P. Bernardini, J. J. Wei, Lihui Wu, Yujuan Liu, J. Liu, Yao Ming Liang, Z. Xu, A. Parenti, L. Feng, Yun-Zhi Zhang, A. Ruina, D. Mo, M. Y. Cui, Xin Wu, L. Silveri, Jun-jun Guo, Yu-Sa Wang, Hong Yun Zhao, W. Li, Hu-Rong Yao, Jinyuo Song, Z. Z. Xu, Z. X. Dong, Yan Fang Wang, Kun Fang, Y. Zhang, A. D'Amone, H. Su, Meng Su, A. Kotenko, Maria Ionica, Jie Kong, Shi-Jun Lei, Sheng Xia Zhang, Q. Yuan, Guangshun Huang, R. R. Fan, Peng-Xiong Ma, Xun Feng Zhao, Zhi Hui Xu, S.X. Li, A. Surdo, Yu-Xuan Zhu, X. J. Teng, Tie-Kuang Dong, W. H. Shen, Z. T. Shen, D. D'Urso, Zu-Cheng Chen, L. G. Wang, Dong Ya Guo, Xiaoyuan Huang, Y. M. Hu, F. de Palma, Hao Ting Dai, C. Perrina, Tianxiao Ma, Donghong Chen, Kai-Kai Duan, Maksym Deliyergiyev, D. Kyratzis, K. Gong, Chengrui Zhou, Mn Mazziotta, G. Z. Shang, Shuang Xue Han, J. J. Zang, Huaguang Wang, Alemanno F., An Q., Azzarello P., Barbato F.C.T., Bernardini P., Bi X.J., Cai M.S., Catanzani E., Chang J., Chen D.Y., Chen J.L., Chen Z.F., Cui M.Y., Cui T.S., Cui Y.X., Dai H.T., D'amone A., De Benedittis A., De Mitri I., De Palma F., Deliyergiyev M., Di Santo M., Dong T.K., Dong Z.X., Donvito G., Droz D., Duan J.L., Duan K.K., D'urso D., Fan R.R., Fan Y.Z., Fang K., Fang F., Feng C.Q., Feng L., Fusco P., Gao M., Gargano F., Gong K., Gong Y.Z., Guo D.Y., Guo J.H., Guo X.L., Han S.X., Hu Y.M., Huang G.S., Huang X.Y., Huang Y.Y., Ionica M., Jiang W., Kong J., Kotenko A., Kyratzis D., Lei S.J., Li S., Li W.L., Li X., Li X.Q., Liang Y.M., Liu C.M., Liu H., Liu J., Liu S.B., Liu W.Q., Liu Y., Loparco F., Luo C.N., Ma M., Ma P.X., Ma T., Ma X.Y., Marsella G., Mazziotta M.N., Mo D., Niu X.Y., Pan X., Parenti A., Peng W.X., Peng X.Y., Perrina C., Qiao R., Rao J.N., Ruina A., Salinas M.M., Shang G.Z., Shen W.H., Shen Z.Q., Shen Z.T., Silveri L., Song J.X., Stolpovskiy M., Su H., Su M., Sun Z.Y., Surdo A., Teng X.J., Tykhonov A., Wang H., Wang J.Z., Wang L.G., Wang S., Wang X.L., Wang Y., Wang Y.F., Wang Y.Z., Wang Z.M., Wei D.M., Wei J.J., Wei Y.F., Wen S.C., Wu D., Wu J., Wu L.B., Wu S.S., Wu X., Xia Z.Q., Xu H.T., Xu Z.H., Xu Z.L., Xu Z.Z., Xue G.F., Yang H.B., Yang P., Yang Y.Q., Yao H.J., Yu Y.H., Yuan G.W., Yuan Q., Yue C., Zang J.J., Zhang F., Zhang S.X., Zhang W.Z., Zhang Y., Zhang Y.J., Zhang Y.L., Zhang Y.P., Zhang Y.Q., Zhang Z., Zhang Z.Y., Zhao C., Zhao H.Y., Zhao X.F., Zhou C.Y., Zhu Y., Alemanno, F., An, Q., Azzarello, P., Barbato, F. C. T., Bernardini, P., Bi, X. J., Cai, M. S., Catanzani, E., Chang, J., Chen, D. Y., Chen, J. L., Chen, Z. F., Cui, M. Y., Cui, T. S., Cui, Y. X., Dai, H. T., D’Amone, A., De Benedittis, A., De Mitri, I., de Palma, F., Deliyergiyev, M., Di Santo, M., Dong, T. K., Dong, Z. X., Donvito, G., Droz, D., Duan, J. L., Duan, K. K., D’Urso, D., Fan, R. R., Fan, Y. Z., Fang, K., Fang, F., Feng, C. Q., Feng, L., Fusco, P., Gao, M., Gargano, F., Gong, K., Gong, Y. Z., Guo, D. Y., Guo, J. H., Guo, X. L., Han, S. X., Hu, Y. M., Huang, G. S., Huang, X. Y., Huang, Y. Y., Ionica, M., Jiang, W., Kong, J., Kotenko, A., Kyratzis, D., Lei, S. J., Li, S., Li, W. L., Li, X., Li, X. Q., Liang, Y. M., Liu, C. M., Liu, H., Liu, J., Liu, S. B., Liu, W. Q., Liu, Y., Loparco, F., Luo, C. N., Ma, M., Ma, P. X., Ma, T., Ma, X. Y., Marsella, G., Mazziotta, M. N., Mo, D., Niu, X. Y., Pan, X., Parenti, A., Peng, W. X., Peng, X. Y., Perrina, C., Qiao, R., Rao, J. N., Ruina, A., Salinas, M. M., Shang, G. Z., Shen, W. H., Shen, Z. Q., Shen, Z. T., Silveri, L., Song, J. X., Stolpovskiy, M., Su, H., Su, M., Sun, Z. Y., Surdo, A., Teng, X. J., Tykhonov, A., Wang, H., Wang, J. Z., Wang, L. G., Wang, S., Wang, X. L., Wang, Y., Wang, Y. F., Wang, Y. Z., Wang, Z. M., Wei, D. M., Wei, J. J., Wei, Y. F., Wen, S. C., Wu, D., Wu, J., Wu, L. B., Wu, S. S., Wu, X., Xia, Z. Q., Xu, H. T., Xu, Z. H., Xu, Z. L., Xu, Z. Z., Xue, G. F., Yang, H. B., Yang, P., Yang, Y. Q., Yao, H. J., Yu, Y. H., Yuan, G. W., Yuan, Q., Yue, C., Zang, J. J., Zhang, F., Zhang, S. X., Zhang, W. Z., Zhang, Y., Zhang, Y. J., Zhang, Y. L., Zhang, Y. P., Zhang, Y. Q., Zhang, Z., Zhang, Z. Y., Zhao, C., Zhao, H. Y., Zhao, X. F., Zhou, C. Y., and Zhu, Y.

Subjects
Astrophysics::High Energy Astrophysical Phenomena, Dark matter, General Physics and Astronomy, chemistry.chemical_element, FOS: Physical sciences, Cosmic ray, Space (mathematics), 01 natural sciences, 7. Clean energy, Cosmic ray, helium, High Energy Physics - Experiment, Nuclear physics, High Energy Physics - Experiment (hep-ex), 0103 physical sciences, Energy spectrum, cosmic rays, dark matter, space, crystals, 010306 general physics, Helium, Physics, High Energy Astrophysical Phenomena (astro-ph.HE), COSMIC cancer database, detector, Settore FIS/01 - Fisica Sperimentale, calibration, chemistry, Particle, Astrophysics - High Energy Astrophysical Phenomena, Nucleon, performance
Abstract

The measurement of the energy spectrum of cosmic ray helium nuclei from 70 GeV to 80 TeV using 4.5 years of data recorded by the DArk Matter Particle Explorer (DAMPE) is reported in this work. A hardening of the spectrum is observed at an energy of about 1.3 TeV, similar to previous observations. In addition, a spectral softening at about 34 TeV is revealed for the first time with large statistics and well controlled systematic uncertainties, with an overall significance of $4.3\sigma$. The DAMPE spectral measurements of both cosmic protons and helium nuclei suggest a particle charge dependent softening energy, although with current uncertainties a dependence on the number of nucleons cannot be ruled out., Comment: 11 pages, 13 figures, published in Phys. Rev. Lett. Add one more digit for first three columns in Table S2

Published
2021

176. Structure of 8Li from a reaction cross-section measurement.

Author

Fan, G. W., Fukuda, M., Nishimura, D., Cai, X. L., Fukuda, S., Hachiuma, I., Ichikawa, C., Izumikawa, T., Kanazawa, M., Kitagawa, A., Kuboki, T., Lantz, M., Mihara, M., Nagashima, M., Namihira, K., Ohkuma, Y., Ohtsubo, T., Zhongzhou Ren, Sato, S., and Shen, Z. Q.

Subjects
*NUCLEAR physics, *LITHIUM, *NUCLEAR reactions, *PARTICLE interactions, *ENERGY security
Abstract

We have precisely measured reaction cross sections (R) for 8Li using 9Be, 12C, 27Al, and proton targets at intermediate energies by the transmission method. From the energy dependence of the R including the high energy data, the density distribution of 8Li was deduced through a modified Glauber model. It is shown that 8Li has a shorter tail structure in the density as compared with that of 8B and the matter radius of 8Li is similar to those of the other nonhalo Li isotopes. The result is consistent with the previous experiments that there is a tendency for 8Li to be a skin nucleus. [ABSTRACT FROM AUTHOR]

Published
2014
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177. The DArk Matter Particle Explorer mission

Author

M. M. Ma, Y.L. Xin, Shengxia Zhang, Y. Y. Huang, Y. Z. Gong, H.Y. Zhao, P. Fusco, Zhao-Qiang Shen, Peidong Yang, Zhao-Min Wang, Yuan Zhu Wang, Maria Ionica, Jie Kong, Yun Long Zhang, F. Loparco, Dan Jiang, J.N. Dong, Y. L. Li, X. Y. Peng, J. L. Chen, H. S. Chen, S. C. Wen, Y. F. Dong, Jinglai Duan, P. Azzarello, N. H. Liao, X. L. Wang, M. M. Salinas, M. Caragiulo, Ya Peng Zhang, M. Pohl, V. Gallo, W. Zhang, Andrii Tykhonov, Niu Xiaoyang, Hai Tao Xu, X. X. Li, Shi-Jun Lei, G. Marsella, Wei Jiang, Min Gao, M. S. Cai, X. Zhu, Z. X. Dong, Yong Zhou, S. Y. Ma, Wei Liang Li, A. De Benedittis, Q. An, Sha Wu, Deng Yi Chen, Y. F. Wei, J.B. Zhang, T.T. Miao, G. F. Xue, Chuan Yue, Z.L. Yang, Y.F. Liang, P. Bernardini, Yifan Yang, Laiyu Zhang, Jianyi Yang, W. X. Peng, Z. M. Zhang, Giacinto Donvito, L. G. Wang, J. G. Lu, Y. J. Zhang, R. Qiao, Shan-Shan Gao, Zi-Qing Xia, Hui Jun Yao, Zhi-Yu Sun, Fang Fang, Yi-Zhong Fan, S. Vitillo, Jie Liu, S. Li, J. J. Wei, R. R. Fan, Lei Feng, Y. Zhu, K. Xi, A. D'Amone, Peng-Xiong Ma, Ping Zhang, Xun Feng Zhao, Jianli Zhang, M. N. Mazziotta, H. Su, Di Wu, Y. M. Hu, Da Ming Wei, Chang Yi Zhou, A. Surdo, Yang Liu, Yen-Po Wang, D. Droz, D. D'Urso, W. Chen, Jian Wu, Jin Zhou Wang, F. Zhang, Q. Wang, Jian Hua Guo, M. Duranti, X. J. Teng, Tie-Kuang Dong, I. De Mitri, Xiao Yong Ma, W. H. Shen, X.B. Tian, Chao Zhang, Z. T. Shen, Hong Yun Zhao, Z. Xu, Chang Qing Feng, T. S. Cui, Chunjie Wang, Ju-Xian Song, G. Ambrosi, Q.Z. Liu, Xiaohui Wang, Haiyan Wang, Y. Zhang, X.Q. Ma, Meng Su, D. Mo, Yan Fang Wang, R. Asfandiyarov, Yao Ming Liang, B. Bertucci, Stephan Zimmer, Guang Shun Huang, Yang Haibo, X. Jin, Zhenyu Zhang, M. Di Santo, Tao Ma, Xin Wu, M. Y. Cui, Yongjie Zhang, Yu-Hong Yu, H. Liu, J. N. Rao, Qiang Yuan, S. B. Liu, Jilong Zhang, Chi Wang, W.Q. Gan, Wenqiang Liu, V. Vagelli, Zi Zong Xu, Jin Chang, F. J. Gan, F. Gargano, D.L. Zhang, H. W. Wang, Kai-Kai Duan, K. Gong, G. Z. Shang, Shu Xin Wang, J. J. Zang, Chang, J., Ambrosi, G., An, Q., Asfandiyarov, R., Azzarello, P., Bernardini, P., Bertucci, B., Cai, M. S., Caragiulo, M., Chen, D. Y., Chen, H. F., Chen, J. L., Chen, W., Cui, M. Y., Cui, T. S., D'Amone, A., DE BENEDITTIS, Antonio, De Mitri, I., DI SANTO, Margherita, Dong, J. N., Dong, T. K., Dong, Y. F., Dong, Z. X., Donvito, G., Droz, D., Duan, K. K., Duan, J. L., Duranti, M., D'Urso, D., Fan, R. R., Fan, Y. Z., Fang, F., Feng, C. Q., Feng, L., Fusco, P., Gallo, V., Gan, F. J., Gan, W. Q., Gao, M., Gao, S. S., Gargano, F., Gong, K., Gong, Y. Z., Guo, J. H., Hu, Y. M., Huang, G. S., Huang, Y. Y., Ionica, M., Jiang, D., Jiang, W., Jin, X., Kong, J., Lei, S. J., Li, S., Li, X., Li, W. L., Li, Y., Liang, Y. F., Liang, Y. M., Liao, N. H., Liu, Q. Z., Liu, H., Liu, J., Liu, S. B., Liu, W. Q., Liu, Y., Loparco, F., Lã¼, J., Ma, M., Ma, P. X., Ma, S. Y., Ma, T., Ma, X. Q., Ma, X. Y., Marsella, G., Mazziotta, M. N., Mo, D., Miao, T. T., Niu, X. Y., Pohl, M., Peng, X. Y., Peng, W. X., Qiao, R., Rao, J. N., Salinas, M. M., Shang, G. Z., Shen, W. H., Shen, Z. Q., Shen, Z. T., Song, J. X., Su, H., Su, M., Sun, Z. Y., Surdo, A., Teng, X. J., Tian, X. B., Tykhonov, A., Vagelli, V., Vitillo, S., Wang, C., Wang, Chi, Wang, H., Wang, H. Y., Wang, J. Z., Wang, L. G., Wang, Q., Wang, S., Wang, X. H., Wang, X. L., Wang, Y. F., Wang, Y. P., Wang, Y. Z., Wen, S. C., Wang, Z. M., Wei, D. M., Wei, J. J., Wei, Y. F., Wu, D., Wu, J., Wu, S. S., Wu, X., Xi, K., Xia, Z. Q., Xin, Y. L., Xu, H. T., Xu, Z. L., Xu, Z. Z., Xue, G. F., Yang, H. B., Yang, J., Yang, P., Yang, Y. Q., Yang, Z. L., Yao, H. J., Yu, Y. H., Yuan, Q., Yue, C., Zang, J. J., Zhang, C., Zhang, D. L., Zhang, F., Zhang, J. B., Zhang, J. Y., Zhang, J. Z., Zhang, L., Zhang, P. F., Zhang, S. X., Zhang, W. Z., Zhang, Y., Zhang, Y. J., Zhang, Y. Q., Zhang, Y. L., Zhang, Y. P., Zhang, Z., Zhang, Z. Y., Zhao, H., Zhao, H. Y., Zhao, X. F., Zhou, C. Y., Zhou, Y., Zhu, X., Zhu, Y., Zimmer, S., DE BENEDITTIS, ANTONIO, DI SANTO, MARGHERITA, and Lü, J.

Subjects
Physics - Instrumentation and Detectors, Satellite launches, Gamma ray observatories, Astrophysics, Galactic cosmic rays, 01 natural sciences, Cosmology, High Energy Physics - Experiment, High Energy Physics - Experiment (hep-ex), Observatory, Detectors and Experimental Techniques, Cosmic rays , dark matter , space experiments, 010303 astronomy & astrophysics, physics.ins-det, Space science missions, Physics, High Energy Astrophysical Phenomena (astro-ph.HE), astro-ph.HE, Astrophysics::Instrumentation and Methods for Astrophysics, Instrumentation and Detectors (physics.ins-det), Cosmology, Galaxies, Gamma rays, Tellurium compounds, Chinese Academy of Sciences, Dark matter particles, Explorer missions, Galactic cosmic rays, Gamma ray observatories, Satellite launches, Scientific objectives, Space science missions, Cosmic rays, Space Science, Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - High Energy Astrophysical Phenomena, Particle Physics - Experiment, Astrophysics and Astronomy, Astrophysics::High Energy Astrophysical Phenomena, Dark matter, FOS: Physical sciences, Cosmic ray, dark matter, Tellurium compounds, 0103 physical sciences, Cosmic rays, Instrumentation and Methods for Astrophysics (astro-ph.IM), 010308 nuclear & particles physics, hep-ex, Gamma rays, Astronomy, Astronomy and Astrophysics, Galaxies, Chinese academy of sciences, Galaxy, Scientific objectives, Dark matter particles, Chinese Academy of Sciences, Satellite, space experiments, Explorer missions, astro-ph.IM
Abstract

The DArk Matter Particle Explorer (DAMPE), one of the four scientific space science missions within the framework of the Strategic Pioneer Program on Space Science of the Chinese Academy of Sciences, is a general purpose high energy cosmic-ray and gamma-ray observatory, which was successfully launched on December 17th, 2015 from the Jiuquan Satellite Launch Center. The DAMPE scientific objectives include the study of galactic cosmic rays up to $\sim 10$ TeV and hundreds of TeV for electrons/gammas and nuclei respectively, and the search for dark matter signatures in their spectra. In this paper we illustrate the layout of the DAMPE instrument, and discuss the results of beam tests and calibrations performed on ground. Finally we present the expected performance in space and give an overview of the mission key scientific goals., 45 pages, including 29 figures and 6 tables. Published in Astropart. Phys

Published
2017

178. Direct detection of a break in the teraelectronvolt cosmic-ray spectrum of electrons and positrons

Author

J. N. Rao, D. M. Wei, P. Azzarello, Peng-Xiong Ma, Y. H. Yu, Shan-Shan Gao, Chi Wang, Q. An, L. G. Wang, YM Liang, Dong Ya Guo, Min Gao, Z. X. Dong, Jie Liu, Tianxiao Ma, Donghong Chen, Wei Liu, Yifan Yang, Zhihua Zhang, Jun-jun Guo, Y. F. Liang, S. Wang, Huan Zhao, D.L. Zhang, X.Q. Ma, Maria Ionica, Jie Kong, G. Ambrosi, Luzhao Feng, Yu-Sa Wang, Fang Fang, N. H. Liao, D. Mo, Niu Xiaoyang, Yaping Wang, R. Qiao, Qiuju Yuan, I. De Mitri, X.B. Tian, Z. Z. Xu, Zheng Wang, Michael Ma, R. Asfandiyarov, X. X. Li, Y. M. Hu, M. S. Cai, Guangshun Huang, M. Di Santo, H. Liu, J.N. Dong, Z.-Q. Shen, Zhongjie Yang, W. X. Peng, Peidong Yang, Jialong Chen, Stephan Zimmer, Y. F. Wei, K. Xi, Laiyu Zhang, Zhi-Yu Sun, W. Li, F. Loparco, X. L. Wang, Chao Zhang, Y. J. Zhang, Y. Z. Gong, Jindong Zhang, X. Y. Ma, M. Duranti, Kai-Kai Duan, Y. Zhang, Yun-Zhi Zhang, R. R. Fan, Valerio Vagelli, Xixian Wang, Ju-Xian Song, G. Marsella, Meng Su, Yaohui Zhang, Xian-Min Jin, S.X. Li, S. B. Liu, Huijun Yao, Andrii Tykhonov, J. J. Wei, Lihui Wu, X. Y. Peng, H. T. Xu, Yujuan Liu, Hong Yun Zhao, Jie Zhang, S. Y. Ma, Z. Q. Xia, Dan Jiang, Yali Zhou, X. J. Teng, Tie-Kuang Dong, S. C. Wen, Y. Li, A. D'Amone, Yi-Zhong Fan, K. Gong, J. Z. Wang, Yugang Zhang, H. S. Chen, Chengrui Zhou, Giacinto Donvito, Yang Haibo, Zhoubin Zhang, P. Bernardini, W. H. Shen, M. Y. Cui, G. Z. Shang, Chuan Yue, Jindan Zhang, Di Wu, Xin-Fu Zhao, Y. Y. Huang, Z. T. Shen, Qian Wang, P. Fusco, Shumei Wu, J. J. Zang, Y. F. Dong, Jinfei Wu, C. Q. Feng, Jinglai Duan, Huaguang Wang, B. Bertucci, Jin Chang, F. J. Gan, F. Gargano, M. N. Mazziotta, H. Su, Haiqiong Wang, Fengtao Zhang, Z. Xu, Pengchao Zhang, Xin Wu, Y. F. Wang, S. Vitillo, D. Droz, T. S. Cui, V. Gallo, W. Zhang, Wei Jiang, G. F. Xue, S. Garrappa, Yu-Xuan Zhu, D. D'Urso, Shi-Jun Lei, M. M. Salinas, Y.L. Xin, Xi Zhu, Shengxia Zhang, A. Surdo, A. De Benedittis, Wangli Chen, Ambrosi, G., An, Q., Asfandiyarov, R., Azzarello, P., Bernardini, P., Bertucci, B., Cai, M. S., Chang, J., Chen, D. Y., Chen, H. F., Chen, J. L., Chen, W., Cui, M. Y., Cui, T. S., D’Amone, A., De Benedittis, A., De Mitri, I., Di Santo, M., Dong, J. N., Dong, T. K., Dong, Y. F., Dong, Z. X., Donvito, G., Droz, D., Duan, K. K., Duan, J. L., Duranti, M., D’Urso, D., Fan, R. R., Fan, Y. Z., Fang, F., Feng, C. Q., Feng, L., Fusco, P., Gallo, V., Gan, F. J., Gao, M., Gao, S. S., Gargano, F., Garrappa, S., Gong, K., Gong, Y. Z., Guo, D. Y., Guo, J. H., Hu, Y. M., Huang, G. S., Huang, Y. Y., Ionica, M., Jiang, D., Jiang, W., Jin, X., Kong, J., Lei, S. J., Li, S., Li, X., Li, W. L., Li, Y., Liang, Y. F., Liang, Y. M., Liao, N. H., Liu, H., Liu, J., Liu, S. B., Liu, W. Q., Liu, Y., Loparco, F., Ma, M., Ma, P. X., Ma, S. Y., Ma, T., Ma, X. Q., Ma, X. Y., Marsella, G., Mazziotta, M. N., Mo, D., Niu, X. Y., Peng, X. Y., Peng, W. X., Qiao, R., Rao, J. N., Salinas, M. M., Shang, G. Z., H. Shen, W., Shen, Z. Q., Shen, Z. T., Song, J. X., Su, H., Su, M., Sun, Z. Y., Surdo, A., Teng, X. J., Tian, X. B., Tykhonov, A., Vagelli, V., Vitillo, S., Wang, C., Wang, H., Wang, H. Y., Wang, J. Z., Wang, L. G., Wang, Q., Wang, S., Wang, X. H., Wang, X. L., Wang, Y. F., Wang, Y. P., Wang, Y. Z., Wen, S. C., Wang, Z. M., Wei, D. M., Wei, J. J., Wei, Y. F., Wu, D., Wu, J., Wu, L. B., Wu, S. S., Wu, X., Xi, K., Xia, Z. Q., Xin, Y. L., Xu, H. T., Xu, Z. L., Xu, Z. Z., Xue, G. F., Yang, H. B., Yang, P., Yang, Y. Q., Yang, Z. L., Yao, H. J., Yu, Y. H., Yuan, Q., Yue, C., Zang, J. J., Zhang, C., Zhang, D. L., Zhang, F., Zhang, J. B., Zhang, J. Y., Zhang, J. Z., Zhang, L., Zhang, P. F., Zhang, S. X., Zhang, W. Z., Zhang, Y., Zhang, Y. J., Zhang, Y. Q., Zhang, Y. L., Zhang, Y. P., Zhang, Z., Zhang, Z. Y., Zhao, H., Zhao, H. Y., Zhao, X. F., Zhou, C. Y., Zhou, Y., Zhu, X., Zhu, Y., and Zimmer, S.

Subjects
Astrophysics::High Energy Astrophysical Phenomena, Dark matter, FOS: Physical sciences, Cosmic ray, Electron, 01 natural sciences, dark matter, High Energy Physics - Experiment, Nuclear physics, High Energy Physics - Experiment (hep-ex), High Energy Physics - Phenomenology (hep-ph), Positron, cosmic rays, 0103 physical sciences, 010303 astronomy & astrophysics, Cherenkov radiation, High Energy Astrophysical Phenomena (astro-ph.HE), Physics, cosmic rays , dark matter , electrons , space experiments, Multidisciplinary, Annihilation, 010308 nuclear & particles physics, Settore FIS/01 - Fisica Sperimentale, Spectrum (functional analysis), electrons, Galaxy, High Energy Physics - Phenomenology, High Energy Physics::Experiment, space experiments, Astrophysics - High Energy Astrophysical Phenomena
Abstract

High energy cosmic ray electrons plus positrons (CREs), which lose energy quickly during their propagation, provide an ideal probe of Galactic high-energy processes and may enable the observation of phenomena such as dark-matter particle annihilation or decay. The CRE spectrum has been directly measured up to $\sim 2$ TeV in previous balloon- or space-borne experiments, and indirectly up to $\sim 5$ TeV by ground-based Cherenkov $\gamma$-ray telescope arrays. Evidence for a spectral break in the TeV energy range has been provided by indirect measurements of H.E.S.S., although the results were qualified by sizeable systematic uncertainties. Here we report a direct measurement of CREs in the energy range $25~{\rm GeV}-4.6~{\rm TeV}$ by the DArk Matter Particle Explorer (DAMPE) with unprecedentedly high energy resolution and low background. The majority of the spectrum can be properly fitted by a smoothly broken power-law model rather than a single power-law model. The direct detection of a spectral break at $E \sim0.9$ TeV confirms the evidence found by H.E.S.S., clarifies the behavior of the CRE spectrum at energies above 1 TeV and sheds light on the physical origin of the sub-TeV CREs., Comment: 18 pages, 6 figures, Nature in press, doi:10.1038/nature24475

Published
2017

179. Measurement of the Cosmic Ray Helium Energy Spectrum from 70 GeV to 80 TeV with the DAMPE Space Mission.

Author

Alemanno F, An Q, Azzarello P, Barbato FCT, Bernardini P, Bi XJ, Cai MS, Catanzani E, Chang J, Chen DY, Chen JL, Chen ZF, Cui MY, Cui TS, Cui YX, Dai HT, D'Amone A, De Benedittis A, De Mitri I, de Palma F, Deliyergiyev M, Di Santo M, Dong TK, Dong ZX, Donvito G, Droz D, Duan JL, Duan KK, D'Urso D, Fan RR, Fan YZ, Fang K, Fang F, Feng CQ, Feng L, Fusco P, Gao M, Gargano F, Gong K, Gong YZ, Guo DY, Guo JH, Guo XL, Han SX, Hu YM, Huang GS, Huang XY, Huang YY, Ionica M, Jiang W, Kong J, Kotenko A, Kyratzis D, Lei SJ, Li S, Li WL, Li X, Li XQ, Liang YM, Liu CM, Liu H, Liu J, Liu SB, Liu WQ, Liu Y, Loparco F, Luo CN, Ma M, Ma PX, Ma T, Ma XY, Marsella G, Mazziotta MN, Mo D, Niu XY, Pan X, Parenti A, Peng WX, Peng XY, Perrina C, Qiao R, Rao JN, Ruina A, Salinas MM, Shang GZ, Shen WH, Shen ZQ, Shen ZT, Silveri L, Song JX, Stolpovskiy M, Su H, Su M, Sun ZY, Surdo A, Teng XJ, Tykhonov A, Wang H, Wang JZ, Wang LG, Wang S, Wang XL, Wang Y, Wang YF, Wang YZ, Wang ZM, Wei DM, Wei JJ, Wei YF, Wen SC, Wu D, Wu J, Wu LB, Wu SS, Wu X, Xia ZQ, Xu HT, Xu ZH, Xu ZL, Xu ZZ, Xue GF, Yang HB, Yang P, Yang YQ, Yao HJ, Yu YH, Yuan GW, Yuan Q, Yue C, Zang JJ, Zhang F, Zhang SX, Zhang WZ, Zhang Y, Zhang YJ, Zhang YL, Zhang YP, Zhang YQ, Zhang Z, Zhang ZY, Zhao C, Zhao HY, Zhao XF, Zhou CY, and Zhu Y

Abstract

The measurement of the energy spectrum of cosmic ray helium nuclei from 70 GeV to 80 TeV using 4.5 years of data recorded by the Dark Matter Particle Explorer (DAMPE) is reported in this work. A hardening of the spectrum is observed at an energy of about 1.3 TeV, similar to previous observations. In addition, a spectral softening at about 34 TeV is revealed for the first time with large statistics and well controlled systematic uncertainties, with an overall significance of 4.3σ. The DAMPE spectral measurements of both cosmic protons and helium nuclei suggest a particle charge dependent softening energy, although with current uncertainties a dependence on the number of nucleons cannot be ruled out.

Published
2021
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180. Measurement of the cosmic ray proton spectrum from 40 GeV to 100 TeV with the DAMPE satellite.

Author

An Q, Asfandiyarov R, Azzarello P, Bernardini P, Bi XJ, Cai MS, Chang J, Chen DY, Chen HF, Chen JL, Chen W, Cui MY, Cui TS, Dai HT, D'Amone A, De Benedittis A, De Mitri I, Di Santo M, Ding M, Dong TK, Dong YF, Dong ZX, Donvito G, Droz D, Duan JL, Duan KK, D'Urso D, Fan RR, Fan YZ, Fang F, Feng CQ, Feng L, Fusco P, Gallo V, Gan FJ, Gao M, Gargano F, Gong K, Gong YZ, Guo DY, Guo JH, Guo XL, Han SX, Hu YM, Huang GS, Huang XY, Huang YY, Ionica M, Jiang W, Jin X, Kong J, Lei SJ, Li S, Li WL, Li X, Li XQ, Li Y, Liang YF, Liang YM, Liao NH, Liu CM, Liu H, Liu J, Liu SB, Liu WQ, Liu Y, Loparco F, Luo CN, Ma M, Ma PX, Ma SY, Ma T, Ma XY, Marsella G, Mazziotta MN, Mo D, Niu XY, Pan X, Peng WX, Peng XY, Qiao R, Rao JN, Salinas MM, Shang GZ, Shen WH, Shen ZQ, Shen ZT, Song JX, Su H, Su M, Sun ZY, Surdo A, Teng XJ, Tykhonov A, Vitillo S, Wang C, Wang H, Wang HY, Wang JZ, Wang LG, Wang Q, Wang S, Wang XH, Wang XL, Wang YF, Wang YP, Wang YZ, Wang ZM, Wei DM, Wei JJ, Wei YF, Wen SC, Wu D, Wu J, Wu LB, Wu SS, Wu X, Xi K, Xia ZQ, Xu HT, Xu ZH, Xu ZL, Xu ZZ, Xue GF, Yang HB, Yang P, Yang YQ, Yang ZL, Yao HJ, Yu YH, Yuan Q, Yue C, Zang JJ, Zhang F, Zhang JY, Zhang JZ, Zhang PF, Zhang SX, Zhang WZ, Zhang Y, Zhang YJ, Zhang YL, Zhang YP, Zhang YQ, Zhang Z, Zhang ZY, Zhao H, Zhao HY, Zhao XF, Zhou CY, Zhou Y, Zhu X, Zhu Y, and Zimmer S

Abstract

The precise measurement of the spectrum of protons, the most abundant component of the cosmic radiation, is necessary to understand the source and acceleration of cosmic rays in the Milky Way. This work reports the measurement of the cosmic ray proton fluxes with kinetic energies from 40 GeV to 100 TeV, with 2 1 / 2 years of data recorded by the DArk Matter Particle Explorer (DAMPE). This is the first time that an experiment directly measures the cosmic ray protons up to ~100 TeV with high statistics. The measured spectrum confirms the spectral hardening at ~300 GeV found by previous experiments and reveals a softening at ~13.6 TeV, with the spectral index changing from ~2.60 to ~2.85. Our result suggests the existence of a new spectral feature of cosmic rays at energies lower than the so-called knee and sheds new light on the origin of Galactic cosmic rays., (Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).)

Published
2019
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181. Design of fuzzy cognitive maps using neural networks for predicting chaotic time series.

Author

Song HJ, Miao CY, Shen ZQ, Roel W, Maja DH, and Francky C

Subjects
Algorithms, Artificial Intelligence, Computer Simulation, Learning, Fuzzy Logic, Neural Networks, Computer, Pattern Recognition, Automated, Problem Solving
Abstract

As a powerful paradigm for knowledge representation and a simulation mechanism applicable to numerous research and application fields, Fuzzy Cognitive Maps (FCMs) have attracted a great deal of attention from various research communities. However, the traditional FCMs do not provide efficient methods to determine the states of the investigated system and to quantify causalities which are the very foundation of the FCM theory. Therefore in many cases, constructing FCMs for complex causal systems greatly depends on expert knowledge. The manually developed models have a substantial shortcoming due to model subjectivity and difficulties with accessing its reliability. In this paper, we propose a fuzzy neural network to enhance the learning ability of FCMs so that the automatic determination of membership functions and quantification of causalities can be incorporated with the inference mechanism of conventional FCMs. In this manner, FCM models of the investigated systems can be automatically constructed from data, and therefore are independent of the experts. Furthermore, we employ mutual subsethood to define and describe the causalities in FCMs. It provides more explicit interpretation for causalities in FCMs and makes the inference process easier to understand. To validate the performance, the proposed approach is tested in predicting chaotic time series. The simulation studies show the effectiveness of the proposed approach., (Copyright © 2010 Elsevier Ltd. All rights reserved.)

Published
2010
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182. Ischemic postconditioning modified renal oxidative stress and lipid peroxidation caused by ischemic reperfusion injury in rats.

Author

Yun Y, Duan WG, Chen P, Wu HX, Shen ZQ, Qian ZY, and Wang DH

Subjects
Animals, Blood Urea Nitrogen, Catalase metabolism, Catalase pharmacology, Disease Models, Animal, Gene Expression Regulation, Enzymologic, Glutathione metabolism, Kidney pathology, Peroxidase metabolism, Postoperative Complications physiopathology, Rats, Reperfusion Injury prevention & control, Superoxide Dismutase genetics, Superoxide Dismutase metabolism, Lipid Peroxidation drug effects, Oxidative Stress physiology, Reperfusion Injury physiopathology
Abstract

Several recent studies have shown that ischemic postconditioning (IPostC) protects hears from ischemic reperfusion insults in various animal models. However, the mechanism of IPostC remains unclear. In the present study, we investigated the hypothesis that PostC protected kidneys against ischemic reperfusion injury by modifying renal oxidative stress and lipid peroxidation. Rats underwent 45 minutes of renal pedicle ligature followed by reperfusion for 1, 3, 6, 12, or 24 hours. IPostC was performed using 6, 10 second cycles of reperfusion and 10 seconds of renal pedicle occlusion at the end of the ischemia. Our data showed that IPostC attenuated renal dysfunction, significantly increasing the activity of antioxidases, including superoxide dismutase (SOD), catalase (CAT), and glutathione perokidase (GSH-Px) in renal homogenates, and concentrations of GSH and SOD expression. The level of malondialdehyde (MDA) and the activity of myeloperoxidase (MPO) were significantly decreased in IPostC rats. These results indicated that the protective effects of IPosC may be related to modification of renal oxidative stress and lipid peroxidation caused by ischemic reperfusion injury in rats.

Published
2009
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183. Down-regulation of cyclooxygenase-2 is involved in ischemic postconditioning protection against renal ischemia reperfusion injury in rats.

Author

Yun Y, Duan WG, Chen P, Wu HX, Shen ZQ, Qian ZY, and Wang DH

Subjects
Animals, Blood Urea Nitrogen, Creatinine blood, Cyclooxygenase 1 metabolism, Ischemia physiopathology, Male, Postoperative Complications epidemiology, Rats, Rats, Sprague-Dawley, Reperfusion Injury epidemiology, Reperfusion Injury prevention & control, Cyclooxygenase 2 metabolism, Kidney Transplantation adverse effects
Abstract

Ischemic postconditioning (IPostC) is a phenomenon whereby rapid intermittent interruptions of blood flow in the early phase of reperfusion protect an organ from ischemia-reperfusion injury. In the present study, we investigated whether the protective effect of IPostC was associated with the cyclooxygenase-2 (COX-2) pathway by evaluating its expression following renal ischemia-reperfusion in rats. Animals underwent 45 minutes of renal pedicle occlusion followed by reperfusion for 1.5, 3, 6, 12, or 24 hours. IPostC was performed by six 10-second cycles of reperfusion and 10 seconds of renal pedicle occlusion at the end of ischemia. Blood and kidney samples were collected at each reperfusion time point. The protein expression of COX-1 and COX-2 were evaluated by Western blotting. Our data showed that IPostC attenuated the renal dysfunction and decreased COX-2 expression induced by ischemia-reperfusion insults. The results indicated that the protective effect of IPostC was related to down-regulation of COX-2 expression.

Published
2009
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184. A novel flocculant of Al(OH)3-polyacrylamide ionic hybrid.

Author

Yang WY, Qian JW, and Shen ZQ

Abstract

A novel flocculant based on hybrid Al(OH)(3)-polyacrylamide (HAPAM) has been synthesized using a redox initiation system ((NH(4))(2)S(2)O(8)-NaHSO(3)) at 40 degrees C in aqueous medium. The HAPAM was characterized by viscometry, IR spectroscopy, TEM, conductivity, and TGA. The flocculation behavior for 0.25 wt% kaolin suspension was evaluated by spectrophotometry and phase contrast microscopy. It was found that an ionic bond exists between Al(OH)(3) colloid and polyacrylamide (PAM) chains in the HAPAM and the flocculation efficiency of HAPAM is much better than that of commercial polyacrylamide (PAM) and PAM/AlCl(3) blend.

Published
2004
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185. Effect of copper aspirinate on contraction of isolated rabbit aortic strips.

Author

Yang WM, Shen ZQ, Chen ZH, Li L, Peng F, and Liu WP

Subjects
Animals, Aorta drug effects, Female, Male, Norepinephrine antagonists & inhibitors, Potassium Chloride antagonists & inhibitors, Rabbits, Aspirin analogs & derivatives, Aspirin pharmacology, Muscle Contraction drug effects, Muscle, Smooth, Vascular drug effects
Abstract

Aim: To investigate the effect of copper aspirinate on contraction of vascular smooth muscle., Methods: Isolated rabbit aortic strips, including intact endothelium strips and endothelial cell-denuded aortic strips, were suspended in modified Krebs'solution to determine effects of copper aspirinate on the contraction induced by norepinephrine (NE), KCl, and CaCl2, while CuSO4, aspirin, and vehicle were used as controls., Results: Copper aspirinate possessed antagonistic effect on contraction of rabbit aortic strips induced by NE with an IC50 value of 31 nmol/L, while CuSO4 had much l ess antagonistic effect with an IC50 value of 0.29 micromol/L, and aspirin did not work in the same preparation. No effect of copper aspirinate were found on the contraction induced by KCl and CaCl2. Effects on endothelial cell denuded aortic strips were similar to those in the normal aortic strips., Conclusion: Copper aspirinate possessed different effects from aspirin and CuSO4 on vascular smooth muscles. It inhibited contraction induced by NE with an activity stronger than CuSO4 at the same Cu2+ concentration, this action might be due to blockade of the receptor-operated Ca2+ channels, and it might not be linked to the endothelium.

Published
2001

186. Paeonilide, a novel anti-PAF-active monoterpenoid-derived metabolite from Paeonia delavayi.

Author

Liu JK, Ma YB, Wu DG, Lu Y, Shen ZQ, Zheng QT, and Chen ZH

Subjects
Drugs, Chinese Herbal metabolism, Molecular Conformation, Plant Roots chemistry, Plant Roots metabolism, Plants, Medicinal metabolism, Platelet Aggregation Inhibitors classification, Platelet Aggregation Inhibitors isolation & purification, Terpenes classification, Terpenes isolation & purification, Drugs, Chinese Herbal chemistry, Plants, Medicinal chemistry, Platelet Activating Factor antagonists & inhibitors, Platelet Aggregation Inhibitors chemistry, Terpenes chemistry
Abstract

A novel monoterpenoid-derived metabolite, paeonilide, was isolated from the roots of Paeonia delavayi. Its structure was established by a combination of spectroscopic and X-ray crystallographic analyses. It showed an anti-PAF effect with an IC50 value of ca. 8 microg/ml.

Published
2000
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187. Effect of protopine on cytosolic Ca2+ in rabbit platelets.

Author

Shen ZQ, Chen ZH, and Duan L

Subjects
Adenosine Diphosphate antagonists & inhibitors, Animals, Arachidonic Acid antagonists & inhibitors, Benzophenanthridines, Biological Transport, Active, Female, Male, Platelet Activating Factor antagonists & inhibitors, Rabbits, Alkaloids pharmacology, Berberine Alkaloids, Blood Platelets metabolism, Calcium blood, Platelet Aggregation Inhibitors pharmacology
Abstract

Aim: To study the influence of protopine (Pro) on the cytoplasmic free Ca2+ concentration ([Ca2+]i) in rabbit platelets., Methods: Measurement of [Ca2+]i of platelets in vitro by Fura 2-AM fluorescence technique., Results: In the presence of CaCl2 1 mmol.L-1, Pro 10, 20, and 40 mumol.L-1 attenuated the rise in [Ca2+]i evoked by ADP from (420 +/- 57) to (320 +/- 26), (264 +/- 21), and (180 +/- 14) nmol.L-1, respectively, by arachidonic acid (AA) from (280 +/- 36) to (210 +/- 17), (184 +/- 21), and (143 +/- 16) nmol.L-1, respectively, and by platelet-activating factor (PAF) from (350 +/- 42) to (282 +/- 31), (223 +/- 30), and (165 +/- 15) nmol.L-1, respectively. In the presence of egtazic acid 1 mmol.L-1, Pro 10, 20, and 40 mumol.L-1 reduced the Ca2+ release induced by ADP, AA, and PAF, respectively. Pro 10, 20, and 40 mumol.L-1 also decreased ADP-, AA-, and PAF-induced Ca2+ influx., Conclusion: Pro inhibited not only Ca2+ release but also the influx of Ca2+.

Published
1999

188. Effects of copper-aspirin complex on plasma 6-keto-prostaglandin F(1alpha) level and platelet cytosolic calcium in rabbits.

Author

Shen ZQ, Li L, Wu LO, Liu WP, and Chen ZH

Abstract

Effects of copper-aspirin complex on washed platelet aggregation, thromboxane B(2) formation and 6-ketoprostaglandin F(1alpha) level were monitored by Born's and Terashita's methods, respectively. The influence of copper-aspirin complex on cytosolic free calcium was examined using the fluorescent indicator, Fura 2-AM. Copper-aspirin complex significantly inhibited arachidonic acid-induced aggregation in washed platelets. The IC(50) value was 9.6 micromol L(-1). Copper-aspirin complex significantly decreased arachidonic acid-induced thromboxane B(2) formation by 87.1% in washed platelets. Ten mg kg(-1) of copper-aspirin complex given intragastrically markedly increased the plasma level of 6-keto-prostaglandin F(1alpha). Aspirin, however, reduced both thromboxane B(2) formation and 6-keto-prostaglandin F(1alpha) level. In the presence of CaCl2 1 mmol L(-1), copper-aspirin complex (20, 40 and 80 micromol L(-1)) markedly lowered arachidonic acid-induced increase in platelet calcium from the resting level (270+/-36 nmol L(-1)) to 213+/-14, 170+/-20 and 135+/-17 nmol L(-1), respectively. In the presence of ethylene glycol-bis (beta-aminoethyl ether) N,N,N',N'-tetraacetic acid 1 mmol L(-1), copper-aspirin complex (20, 40 and 80 micromol l L(-1)) significantly suppressed the release of intracellular calcium induced by arachidonic acid from 127+/-23 nmol L-1 to 108+/-17, 93+/-12 and 70+/-13 nmol L(-1).

Published
1999
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189. Inhibitory effects of copper-aspirin complex on platelet aggregation.

Author

Shen ZQ, Chen ZH, Ma GY, Wang DC, Wu WL, Liu WP, Yang YK, and Xiong HZ

Subjects
6-Ketoprostaglandin F1 alpha blood, Animals, Aspirin pharmacology, Blood Platelets metabolism, Female, Male, Rabbits, Serotonin blood, Thromboxane B2 biosynthesis, Anti-Inflammatory Agents, Non-Steroidal pharmacology, Aspirin analogs & derivatives, Platelet Aggregation drug effects, Platelet Aggregation Inhibitors pharmacology
Abstract

Aim: To study the inhibitory effects of copper-aspirin complex (CuAsp) on platelet aggregation., Methods: With adenosine diphosphate the effects of CuAsp on platelet aggregation in vitro or in vivo were investigated. Radioimmunoassay and fluorophotometry were used to measure thromboxane B2 (TXB2) generation from platelets, the levels of TXB2 and of 6-keto-PGF1 alpha in plasma and the platelet serotonin release reaction., Results: In vitro, CuAsp inhibited arachidonic acid (AA)-induced aggregation (IC50 = 17 mumol.L-1, 95% confidence limits: 9-33 mumol.L-1), the release of 5-HT (IC50 = 19 mumol.L-1, 95% confidence limits: 10-30 mumol.L-1), and TXB2 generation from platelets (P < 0.05). CuAsp 10 mg.kg-1 i.g. selectively inhibited AA-induced aggregation, and increased the 6-keto-PGF1 alpha concentration in plasma while decreased that of TXB2., Conclusion: CuAsp, in vitro or in vivo, shows more potent inhibitory effects on AA-induced aggregation than aspirin (Asp), related to the inhibition of platelet cyclooxygenase and the release of active substances from platelets.

Published
1997

190. Application of biotin-avidin system, determination of circulating immune complexes, and evaluation of antibody response in different hydatidosis patients.

Author

Shen ZQ, Feng XH, Qian ZX, Liu RL, and Yang CR

Subjects
Animals, Avidin, Biotin, Echinococcosis diagnosis, Enzyme-Linked Immunosorbent Assay, Humans, Predictive Value of Tests, Antibodies, Helminth analysis, Antigen-Antibody Complex analysis, Echinococcosis immunology, Echinococcus immunology
Abstract

The avidin-biotin-peroxidase complex enzyme-linked immunosorbent assay (ABC-ELISA) and standard ELISA were used for the detection of Echinococcus granulosus antibody in sera of 101 patients operated on for hydatid disease, 40 patients with miscellaneous nonhydatid diseases, and 61 normal subjects. Sensitivity and specificity of the two procedures were comparable and the geometric mean antibody titer detected with ABC-ELISA was higher than with standard ELISA. The ABC-ELISA is a sensitive, specific, simple, and convenient method for diagnosing hydatidosis.

Published
1988

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