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In this work we theoretically and experimentally analyze the resonant behavior of individual 3 × 3 gold particle oligomers illuminated under normal and oblique incidence. While this structure hosts both dipolar and quadrupolar electric and magnetic delocalized modes, only dipolar electric and quadrupolar magnetic modes remain at normal incidence. These modes couple into a strongly asymmetric spectral response typical of a Fano-like resonance. In the basis of the coupled mode theory, an analytical representation of the optical extinction in terms of singular functions is used to identify the hybrid modes emerging from the electric and magnetic mode coupling and to interpret the asymmetric line profiles. Especially, we demonstrate that the characteristic Fano line shape results from the spectral interference of a broad hybrid mode with a sharp one. This structure presents a special feature in which the electric field intensity is confined on different lines of the oligomer depending on the illumination wavelength relative to the Fano dip. This Fano-type resonance is experimentally observed performing extinction cross section measurements on arrays of gold nano-disks. The vanishing of the Fano dip when increasing the incidence angle is also experimentally observed in accordance with numerical simulations.

Background and aimsSmoke-free psychiatric hospitalisation provides opportunity for initiating tobacco cessation treatment. The current study reports on psychiatric patients' interest in continuing nicotine replacement therapy (NRT) posthospitalisation and examines patient predictors of NRT requests, quit attempts and abstinence at 1-week follow-up.MethodsDaily smokers were recruited and interviewed on locked psychiatric units at three smoke-free San Francisco Bay Area hospitals. Intent to quit smoking was not required to participate and 73% of eligible smokers enrolled. Analyses focused on 816 participants (49% female) randomised to interventions providing counselling tailored to readiness to quit with availability of NRT posthospitalisation. Logistic regressions tested demographic, smoking and psychiatric factors predictive of NRT requests, quit attempts and abstinence 1-week postdischarge.ResultsParticipants averaged 17 (SD=10) cigarettes/day for an average of 19 (SD=14) years. Most (88%) requested study-provided NRT (74% right at discharge). Participants preparing to quit and those with more severe psychiatric symptoms were more likely to request NRT at discharge (p

Children with Attention Deficit/Hyperactivity Disorder (ADHD) receive approximately 80% of instruction in the general education classroom, where individualized behavioral management strategies may be difficult for teachers to consistently deliver. Mobile device apps provide promising platforms to manage behavior. This pilot study evaluated the utility of a web-based application (iSelfControl) designed to support classroom behavior management. iSelfControl prompted students every 'Center' (30-minutes) to self-evaluate using a universal token-economy classroom management system focused on compliance, productivity, and positive relationships. Simultaneously, the teacher evaluated each student on a separate iPad. Using Multi Level Modeling, we examined 13 days of data gathered from implementation with 5th grade students (N = 12) at a school for children with ADHD and related executive function difficulties. First, an unconditional growth model evaluated the overall amount of change in aggregated scores over time as well as the degree of systematic variation in scores within and across teacher-student dyads. Second, separate intercepts and slopes were estimated for teacher and student to estimate degree of congruency between trajectories. Finally, differences between teacher and student scores were tested at each time-point in separate models to examine unique 'Center' effects. 51% of the total variance in scores was attributed to differences between dyads. Trajectories of student and teacher scores remained relatively stable across seven time-points each day and did not statistically differ from each other. On any given day, students tended to evaluate their behaviors more positively (entered higher scores for themselves) compared to corresponding teacher scores. In summary, iSelfControl provides a platform for self and teacher evaluation that is an important adjunct to conventional classroom management strategies. The application captured teacher/student discrepancies and significant variations across the day. Future research with a larger, clinically diagnosed sample in multiple classrooms is needed to assess generalizability to a wider variety of classroom settings.

ObjectiveThe objective of this study was to investigate the effect of mechanical strain by mapping physicochemical properties at periodontal ligament (PDL)-bone and PDL-cementum attachment sites and within the tissues per se.DesignAccentuated mechanical strain was induced by applying a unidirectional force of 0.06N for 14 days on molars in a rat model. The associated changes in functional space between tooth and bone, mineral formation and resorbing events at the PDL-bone and PDL-cementum attachment sites were identified by using micro-X-ray computed tomography (micro-XCT), atomic force microscopy (AFM), dynamic histomorphometry, Raman microspectroscopy, AFM-based nanoindentation technique, and were correlated with histochemical stains specific to low and high molecular weight GAGs, including biglycan, and osteoclast distribution through tartrate-resistant acid phosphatase (TRAP) staining.ResultsUnique chemical and mechanical qualities including heterogenous bony fingers with hygroscopic Sharpey's fibers contributing to a higher organic (amide III - 1240 cm-1) to inorganic (phosphate - 960 cm-1) ratio, with lower average elastic modulus of 8 GPa versus 12 GPa in unadapted regions were identified. Furthermore, an increased presence of elemental Zn in cement lines and mineralizing fronts of PDL-bone was observed. Adapted regions containing bony fingers exhibited woven bone-like architecture and these regions rich in biglycan (BGN) and bone sialoprotein (BSP) also contained high-molecular weight polysaccharides predominantly at the site of polarized bone growth.ConclusionsFrom a fundamental science perspective the shift in local properties due to strain amplification at the soft-hard tissue attachment sites is governed by semiautonomous cellular events at the PDL-bone and PDL-cementum sites. Over time, these strain-mediated events can alter the physicochemical properties of tissues per se, and consequently the overall biomechanics of the bone-PDL-tooth complex. From a clinical perspective, the shifts in magnitude and duration of forces on the periodontal ligament can prompt a shift in physiologic mineral apposition in cementum and alveolar bone albeit of an adapted quality owing to the rapid mechanical translation of the tooth.

The provision and maintenance of quality teachers is a matter of priority for the profession. Moreover, teacher attrition is costly to the profession, to the community and to those teachers who leave feeling disillusioned. There is a need to investigate the experiences of early career teachers to consider how these issues contribute to decisions about staying in or leaving the profession. This paper reports on an aspect of a larger study on teacher retention. It describes and analyses the experiences of teachers participating in the study and highlights implications for teacher retention. The study proposes the notion of "resilient stayers", and how beginning teachers' resilience might be strengthened and supported. It asks what combination of circumstances in the school and the system, and individual resources of resilience on the part of early career teachers, might maximise the chances of teachers choosing to remain in the profession.

In this brief review, we summarize and elaborate on some of the nomenclature of polaritonic phenomena and systems as they appear in the literature on quantum materials and quantum optics. Our summary includes at least 70 different types of polaritonic light–matter dressing effects. This summary also unravels a broad panorama of the physics and applications of polaritons. A constantly updated version of this review is available at https://infrared.cni.columbia.edu.

The formation dynamics of excitons in 2D transition metal dichalcogenides are challenging to probe directly because of their inherently fast timescales. Here, the authors use extremely short optical pulses to excite an electron-hole plasma, and show the formation of 2D excitons in MoS2 on the timescale of 30 fs.

The authors use time-resolved scanning near-field optical microscopy to probe the ultrafast excitonic processes and their impact on waveguide operation in transition metal dichalcogenide crystals. They observe significant modulation of the complex index by monitoring waveguide modes on the fs time scale, and identify both coherent and incoherent manipulations of WSe2 excitonic resonances.

Derivation of mean age of air (AoA) and age spectra from atmospheric measurements remains a challenge and often requires output from atmospheric models. This study tries to minimize the direct influence of model output and presents an extension and application of a previously established inversion method to derive age spectra from mixing ratios of long- and short-lived trace gases. For a precise description of cross-tropopause transport processes, the inverse method is extended to incorporate air entrainment into the stratosphere across the tropical and extratropical tropopause. We first use simulations with the Chemical Lagrangian Model of the Stratosphere (CLaMS) to provide a general proof of concept of the extended principle in a controllable and consistent environment, where the method is applied to an idealized set of 10 trace gases with predefined constant lifetimes and compared to reference model age spectra. In the second part of the study we apply the extended inverse method to atmospheric measurements of multiple long- and short-lived trace gases measured aboard the High Altitude and Long Range (HALO) research aircraft during the two research campaigns POLSTRACC–GW-LCYCLE–SALSA (PGS) and Wave-driven Isentropic Exchange (WISE). As some of the observed species undergo significant loss processes in the stratosphere, a Monte Carlo simulation is introduced to retrieve age spectra and chemical lifetimes in stepwise fashion and to account for the large uncertainties. Results show that in the idealized model scenario the inverse method retrieves age spectra robustly on annual and seasonal scales. The extension to multiple entry regions proves reasonable as our CLaMS simulations reveal that in the model between 50 % and 70 % of air in the lowermost stratosphere has entered through the extratropical tropopause (30–90∘ N and S) on annual average. When applied to observational data of PGS and WISE, the method derives age spectra and mean AoA with meaningful spatial distributions and quantitative range, yet large uncertainties. Results indicate that entrainment of fresh tropospheric air across both the extratropical and tropical tropopause peaked prior to both campaigns, but with lower mean AoA for WISE than PGS data. The ratio of moments for all retrieved age spectra for PGS and WISE is found to range between 0.52 and 2.81 years. We conclude that the method derives reasonable and consistent age spectra using observations of chemically active trace gases. Our findings might contribute to an improved assessment of transport with age spectra in future studies.

O presente estudo tem como tema as Tecnologias Digitais de Informação e Comunicação (TDICs) no processo de ensino de Geografia nos anos finais do Ensino Fundamental. Tal abordagem vai além de equipamentos como computadores, celulares e videogames. Esse conceito abrange as transformações ocorridas, sobretudo com o surgimento e a expansão da internet, que alteram os modos de vida e os relacionamentos nos mais diferentes setores e segmentos da sociedade, inclusive na educação. A metodologia adotada foi em torno das concepções da abordagem qualitativa, com pesquisa de campo, sob o enfoque fenomenológico. Como técnicas para a geração de dados, foram usadas observação, entrevista semiestruturada e aplicação de questionários. Os sujeitos da pesquisa foram 05 professores de Geografia e 26 alunos do 6º ao 9º ano do Ensino Fundamental em três escolas da rede municipal de ensino de Imperatriz - MA. Para tanto são apresentados os resultados da pesquisa sobre a percepção dos professores e alunos em relação às facilidades e/ou dificuldades que cercam o uso das TDICs e de que forma o uso dessas tecnologias pode contribuir, ou não, para o ensino dessa disciplina.

We present novel measurements of five short-lived brominated source gases (CH2Br2, CHBr3, CH2ClBr, CHCl2Br and CHClBr2). These rather short-lived gases are an important source of bromine to the stratosphere, where they can lead to depletion of ozone. The measurements have been obtained using an in situ gas chromatography and mass spectrometry (GC–MS) system on board the High Altitude and Long Range Research Aircraft (HALO). The instrument is extremely sensitive due to the use of chemical ionization, allowing detection limits in the lower parts per quadrillion (ppq, 10−15) range. Data from three campaigns using HALO are presented, where the upper troposphere and lower stratosphere (UTLS) of the northern hemispheric mid-to-high latitudes were sampled during winter and during late summer to early fall. We show that an observed decrease with altitude in the stratosphere is consistent with the relative lifetimes of the different compounds. Distributions of the five source gases and total organic bromine just below the tropopause show an increase in mixing ratio with latitude, in particular during polar winter. This increase in mixing ratio is explained by increasing lifetimes at higher latitudes during winter. As the mixing ratios at the extratropical tropopause are generally higher than those derived for the tropical tropopause, extratropical troposphere-to-stratosphere transport will result in elevated levels of organic bromine in comparison to air transported over the tropical tropopause. The observations are compared to model estimates using different emission scenarios. A scenario with emissions mainly confined to low latitudes cannot reproduce the observed latitudinal distributions and will tend to overestimate organic bromine input through the tropical tropopause from CH2Br2 and CHBr3. Consequently, the scenario also overestimates the amount of brominated organic gases in the stratosphere. The two scenarios with the highest overall emissions of CH2Br2 tend to overestimate mixing ratios at the tropical tropopause, but they are in much better agreement with extratropical tropopause mixing ratios. This shows that not only total emissions but also latitudinal distributions in the emissions are of importance. While an increase in tropopause mixing ratios with latitude is reproduced with all emission scenarios during winter, the simulated extratropical tropopause mixing ratios are on average lower than the observations during late summer to fall. We show that a good knowledge of the latitudinal distribution of tropopause mixing ratios and of the fractional contributions of tropical and extratropical air is needed to derive stratospheric inorganic bromine in the lowermost stratosphere from observations. In a sensitivity study we find maximum differences of a factor 2 in inorganic bromine in the lowermost stratosphere from source gas injection derived from observations and model outputs. The discrepancies depend on the emission scenarios and the assumed contributions from different source regions. Using better emission scenarios and reasonable assumptions on fractional contribution from the different source regions, the differences in inorganic bromine from source gas injection between model and observations is usually on the order of 1 ppt or less. We conclude that a good representation of the contributions of different source regions is required in models for a robust assessment of the role of short-lived halogen source gases on ozone depletion in the UTLS.

Superconducting nanowires with quantum phase slips are promising candidates for future quantum technologies. Here, Lyatti et al. report evidence for energy-level quantization and single photon control of phase slips in ultra-thin YBa2Cu3O7-x nanowires, promising for quantum sensing and computing.

This paper presents a novel bearingless synchronous reluctance slice motor topology that contains no permanent magnets. The rotor with two iron poles and flux barriers is levitated and rotated through a stator winding system with six coils wired as two three-phase systems. A constant rotor-oriented magnetization current is applied to generate a magnetic bias flux. The system can be controlled similar to a bearingless permanent magnet synchronous slice motor and provides passive stabilization of axial and tilting movements of the rotor. The motor topology is discussed in detail and a prototype implementation is presented. Its performance with regard to passive properties, achievable torque, controllability, and wide air gap suitability is benchmarked against two other designs that contain permanent magnets either in the rotor or the stator. A loss analysis of all topologies is performed and suitable application areas are identified. The proposed design provides an interesting alternative to existing bearingless slice motor topologies in applications that require high rotational speeds, high process or ambient temperatures, or a disposable low-cost rotor with short exchange intervals.

Goal: The importance of the main impeller design parameters in bearingless centrifugal pumps with respect to hemolysis for cardiopulmonary bypass (CPB) and extracorporeal membrane oxygenation (ECMO) applications are studied in this work. Methods: Impeller prototypes were designed based on theoretical principles. They were manufactured and their hydraulic and hemolytic performance were analyzed experimentally. The cell compatibility is benchmarked against commercially available centrifugal blood pumps BPX-80 (Medtronic) and FloPump 32 (International Biophysics Corporation). Results: The developed prototypes outperform the BPX-80 and FloPump 32 with regard to hemocompatibility by more than a factor of 4.5. The implemented pump features reduced overall and priming volumes. A significant improvement of the cell compatibility is achieved by increasing the radial gap between the impeller and the pump head. The blade should be sufficiently high and a blade outlet angle of 90° provides favorable performance. No correlation between the hydraulic and hemolytic performance is observed. Conclusions: This work identified the most important geometrical parameters of the impeller for blood pumps with respect to cell compatibility. This provides valuable design guidelines for improving existing pumps.

This paper introduces a bearingless motor topology with a magnet-free rotor that provides a higher rotor torque density and wider magnetic air gap compared to previously published topologies. The stray flux is minimized by using a stator with only eight teeth in temple configuration that contain permanent magnets. The motor performance is analyzed based on experimental prototypes, that were designed using 3D FEM simulations, for even and odd rotor pole pair numbers of six and nine, respectively. Control schemes that compensate parasitic radial forces to achieve stable magnetic levitation of the rotors are presented. The implemented prototypes reached a rotational speed of 2000 rpm and a maximum torque of 8 Nm.

New Zealand's Alpine Fault is a large, plate-bounding strike-slip fault, which ruptures in large (Mw>8) earthquakes. We conducted field and laboratory analyses of fault rocks to assess its fault zone architecture. Results reveal that the Alpine Fault Zone has a complex geometry, comprising an anastomosing network of multiple slip planes that have accommodated different amounts of displacement. This contrasts with the previous perception of the Alpine Fault Zone, which assumes a single principal slip zone accommodated all displacement. This interpretation is supported by results of drilling projects and geophysical investigations. Furthermore, observations presented here show that the young, largely unconsolidated sediments that constitute the footwall at shallow depths have a significant influence on fault gouge rheological properties and structure.

Measurements of halogenated trace gases in ambient air frequently rely on canister sampling followed by offline laboratory analysis. This allows for a large number of compounds to be analysed under stable conditions, maximizing measurement precision. However, individual compounds might be affected during the sampling and storage of canister samples. In order to assess halocarbon stability in whole-air samples from the upper troposphere and lowermost stratosphere, we performed stability tests using the high-resolution sampler (HIRES) air sampling unit, which is part of the Civil Aircraft for the Regular Investigation of the atmosphere Based on an Instrument Container (CARIBIC) instrument package. The HIRES unit holds 88 lightweight stainless-steel cylinders that are pressurized in flight to 4.5 bar using metal bellows pumps. The HIRES unit was first deployed in 2010 but has up to now not been used for regular halocarbon analysis with the exception of chloromethane analysis. The sample collection unit was tested for the sampling and storage effects of 28 halogenated compounds. The focus was on compound stability in the stainless-steel canisters during storage of up to 5 weeks and on the influence of ozone, since flights take place in the upper troposphere and lowermost stratosphere with ozone mixing ratios of up to several hundred parts per billion by volume (ppbv). Most of the investigated (hydro)chlorofluorocarbons and long-lived hydrofluorocarbons were found to be stable over a storage time of up to 5 weeks and were unaltered by ozone being present during pressurization. Some compounds such as dichloromethane, trichloromethane, and tetrachloroethene started to decrease in the canisters after a storage time of more than 2 weeks or exhibited lowered mixing ratios in samples pressurized with ozone present. A few compounds such as tetrachloromethane and tribromomethane were found to be unstable in the HIRES stainless-steel canisters independent of ozone levels. Furthermore, growth was observed during storage for some species, namely for HFC-152a, HFC-23, and Halon 1301.

The substantial progress made in the basic sciences of the brain has yet to be adequately translated to successful clinical therapeutics to treat central nervous system (CNS) diseases. Possible explanations include the lack of quantitative and validated biomarkers, the subjective nature of many clinical endpoints, and complex pharmacokinetic/pharmacodynamic relationships, but also the possibility that highly selective drugs in the CNS do not reflect the complex interactions of different brain circuits. Although computational systems pharmacology modeling designed to capture essential components of complex biological systems has been increasingly accepted in pharmaceutical research and development for oncology, inflammation, and metabolic disorders, the uptake in the CNS field has been very modest. In this article, a cross‐disciplinary group with representatives from academia, pharma, regulatory, and funding agencies make the case that the identification and exploitation of CNS therapeutic targets for drug discovery and development can benefit greatly from a system and network approach that can span the gap between molecular pathways and the neuronal circuits that ultimately regulate brain activity and behavior. The National Institute of Neurological Disorders and Stroke (NINDS), in collaboration with the National Institute on Aging (NIA), National Institute of Mental Health (NIMH), National Institute on Drug Abuse (NIDA), and National Center for Advancing Translational Sciences (NCATS), convened a workshop to explore and evaluate the potential of a quantitative systems pharmacology (QSP) approach to CNS drug discovery and development. The objective of the workshop was to identify the challenges and opportunities of QSP as an approach to accelerate drug discovery and development in the field of CNS disorders. In particular, the workshop examined the potential for computational neuroscience to perform QSP‐based interrogation of the mechanism of action for CNS diseases, along with a more accurate and comprehensive method for evaluating drug effects and optimizing the design of clinical trials. Following up on an earlier white paper on the use of QSP in general disease mechanism of action and drug discovery, this report focuses on new applications, opportunities, and the accompanying limitations of QSP as an approach to drug development in the CNS therapeutic area based on the discussions in the workshop with various stakeholders.

This paper analyzes the compulsory measures adopted by Brazil and Chile in processes of expulsion of migrants. The particular case of Haitian migration is studied, and what its implications have been at the judicial level, through a case study highlighting what have been the criteria and standards applied by the immigration authorities of both countries. In relation to the procedure to be adopted, it is observed that through qualitative research it will be possible to account for the different representations on the subject under study, without neglecting the quantitative method, as it will contribute to the evaluation and categorization of contained data in government information databases, such as data from the Ministry of Justice and Public Security of Brazil, the National Institute of Statistics and the Judiciary of Chile, and the Institute of Public Policies and Human Rights of Mercosur, with the elaboration of a diagnosis of the displacement of Haitians in South American countries, with special emphasis on the migratory realities of Haitians in Brazil and Chile. In the same way, the research includes the analysis of decisions adopted by the Superior Courts of Justice of Chile and Brazil, as well as the documentary and bibliographic survey, especially articles from specialized international magazines on the subject. In addition, the existing laws and public policies in Chile and Brazil, the conventions, protocols and other international instruments that help to better understand the reality studied will be consulted.

ABSTRACT The emergence of SARS-CoV-2 created a crucial need for serology assays to detect anti-SARS-CoV-2 antibodies, which led to many serology assays entering the market. A trans-government collaboration was created in April 2020 to independently evaluate the performance of commercial SARS-CoV-2 serology assays and help inform U.S. Food and Drug Administration (FDA) regulatory decisions. To assess assay performance, three evaluation panels with similar antibody titer distributions were assembled. Each panel consisted of 110 samples with positive (n = 30) serum samples with a wide range of anti-SARS-CoV-2 antibody titers and negative (n = 80) plasma and/or serum samples that were collected before the start of the COVID-19 pandemic. Each sample was characterized for anti-SARS-CoV-2 antibodies against the spike protein using enzyme-linked immunosorbent assays (ELISA). Samples were selected for the panel when there was agreement on seropositivity by laboratories at National Cancer Institute’s Frederick National Laboratory for Cancer Research (NCI-FNLCR) and Centers for Disease Control and Prevention (CDC). The sensitivity and specificity of each assay were assessed to determine Emergency Use Authorization (EUA) suitability. As of January 8, 2021, results from 91 evaluations were made publicly available (https://open.fda.gov/apis/device/covid19serology/, and https://www.cdc.gov/coronavirus/2019-ncov/covid-data/serology-surveillance/serology-test-evaluation.html). Sensitivity ranged from 27% to 100% for IgG (n = 81), from 10% to 100% for IgM (n = 74), and from 73% to 100% for total or pan-immunoglobulins (n = 5). The combined specificity ranged from 58% to 100% (n = 91). Approximately one-third (n = 27) of the assays evaluated are now authorized by FDA for emergency use. This collaboration established a framework for assay performance evaluation that could be used for future outbreaks and could serve as a model for other technologies. IMPORTANCE The SARS-CoV-2 pandemic created a crucial need for accurate serology assays to evaluate seroprevalence and antiviral immune responses. The initial flood of serology assays entering the market with inadequate performance emphasized the need for independent evaluation of commercial SARS-CoV-2 antibody assays using performance evaluation panels to determine suitability for use under EUA. Through a government-wide collaborative network, 91 commercial SARS-CoV-2 serology assay evaluations were performed. Three evaluation panels with similar overall antibody titer distributions were assembled to evaluate performance. Nearly one-third of the assays evaluated met acceptable performance recommendations, and two assays had EUAs revoked and were removed from the U.S. market based on inadequate performance. Data for all serology assays evaluated are available at the FDA and CDC websites (https://open.fda.gov/apis/device/covid19serology/, and https://www.cdc.gov/coronavirus/2019-ncov/covid-data/serology-surveillance/serology-test-evaluation.html).

Esta pesquisa qualitativa investigou o lugar do corpo no Ensino Superior, a partir da análise do discurso de estudantes e professores de graduação que, em 2020, experimentaram aulas virtualizadas no período da pandemia de COVID-19. O contexto de estudo foi uma instituição de Ensino Superior do RS/Brasil. As informações foram coletadas com 245 estudantes e 40 professores, por meio de um questionário elaborado no Google Forms. Em relação ao lugar do corpo nas aulas da graduação, constataram-se compreensões diferentes, que transitam entre a possibilidade de renúncia ao encontro físico e presencial, como no caso do ensino dos conhecimentos teóricos, e as que reclamam da ausência corporal, principalmente, em se tratando do conhecimento construído em aulas práticas, nos laboratórios de ensino e na interação entre estudantes e professores. Conclui-se que ainda há lugar para o corpo no Ensino Superior e que aprendemos na relação com o outro e por meio dos sentidos corporais. Negar o corpo é colocar-se na contramão da essência da existência humana, pois somos corpo e nos fazemos presentes no mundo a partir dele.

Children often perform worse than adults on tasks that require focused attention. While this is commonly regarded as a sign of incomplete cognitive development, a broader attentional focus could also endow children with the ability to find novel solutions to a given task. To test this idea, we investigated children’s ability to discover and use novel aspects of the environment that allowed them to improve their decision-making strategy. Participants were given a simple choice task in which the possibility of strategy improvement was neither mentioned by instructions nor encouraged by explicit error feedback. Among 47 children (8—10 years of age) who were instructed to perform the choice task across two experiments, 27.5% showed a full strategy change. This closely matched the proportion of adults who had the same insight (28.2% of n = 39). The amount of erroneous choices, working memory capacity and inhibitory control, in contrast, indicated substantial disadvantages of children in task execution and cognitive control. A task difficulty manipulation did not affect the results. The stark contrast between age-differences in different aspects of cognitive performance might offer a unique opportunity for educators in fostering learning in children.

Climate services are becoming instrumental for providing actionable climate information to society. To understand the needs of society, climate service providers increasingly engage in processes of co-creation with practitioners. Yet, while these science-practice interactions are highly promising to match the demand and supply side of climate services, they come with challenges of their own. Potential barriers include difficulties in mutual understanding, diverging perspectives on the research problem, or a lack of resources and training in engaging with practice partners. Importantly, however, these barriers are surmountable if properly addressed. In this paper, we present the results of a series of interviews with researchers working in the funding line European Research Area for Climate Services (ERA4CS). We identify five challenges that these researchers are facing in their interactions with practice partners. From these challenges, we infer best practices that can help to strengthen such interactions. In line with other suggestions in the literature, we propose the role of a boundary manager as a promising way to put these best practices into action. This mediating role between science and society either can be taken by scientists themselves, or can be institutionalized as a dedicated position within climate service organizations. Adding to the experience that climate service providers already have, increased emphasis on boundary management could further improve their science-practice engagements

Introdução: Nas últimas décadas, os resultados das artroplastias totais de joelho (ATJ) melhoraram significativamente, contudo, ainda estão sujeitas a complicações, sendo a infecção a mais complexa de ser solucionada. Por isso, o caso relatado a seguir objetiva salientar as manifestações clínicas e o manejo de uma infecção fúngica após artroplastia total do joelho (IATJ). Descrição do caso: Paciente feminina, 83 anos, foi submetida a uma ATJ esquerda em outubro de 2013, com melhora gradual da dor e recuperação funcional. Um ano depois, apresentou dor súbita associada a derrame no joelho esquerdo, sendo realizada punção dessa articulação para cultura, a qual evidenciou a presença de Candida albicans. Diante desse quadro, o infectologista iniciou tratamento com micafungina. Sete dias após o início da terapia, ela estava sem dor, com secreção serosanguinolenta em pouca quantidade na ferida operatória (FO) e 2 dias depois encontrava-se limpa. Assim, a paciente seguiu com a terapia antifúngica via endovenosa em casa. Em dezembro de 2015, ela apresentou dor e derrame articular na prótese do joelho novamente, sendo realizado procedimento de revisão da prótese. Prescreveu-se antibiótico e a paciente permaneceu estável. No dia seguinte, iniciou-se Teicoplanina devido a um episódio de febre. Contudo, com o resultado da cultura - Staphylococcus aureus sensível a Oxacilina - ajustou-se a antibioticoterapia. Comentários: A partir desse caso e da literatura, sabe-se que condições ligadas ao paciente, ao procedimento cirúrgico e ao pós-operatório são fatores de risco para IATJ. Vários são os métodos complementares à investigação clínica para o diagnóstico infeccioso e melhor caracterização do quadro. A terapia para IATJ deve ser individualizada, mas geralmente envolve a combinação da antibioticoterapia sistêmica com a cirurgia. A troca do implante é o procedimento de escolha, sendo o desbridamento com retenção da prótese uma opção em casos agudos. No caso apresentado, o manejo inicial foi com o uso de antifúngico, tendo em vista a cultura positiva para Candida albicans. Posteriormente, com a recidiva dos sintomas, optou-se pela troca da prótese e administração de antimicrobianos. A IATJ está associada ao aumento da morbimortalidade e dos custos de internação, por isso, mesmo com a melhora da técnica da ATJ, é importante o conhecimento da IATJ para que a prevenção, o diagnóstico e o tratamento precoce sejam possíveis.

Delta ( δ ) sunspots sometimes host fast photospheric flows along the central magnetic polarity inversion line (PIL). Here we study the strong Doppler shift signature in the central penumbral light bridge of solar active region NOAA 12673. Observations from the Helioseismic and Magnetic Imager (HMI) indicate highly sheared and strong magnetic fields. Large Doppler shifts up to 3.2 km s ^−1 appeared during the formation of the light bridge and persisted for about 16 hr. A new velocity estimator, called DAVE4VMwDV, reveals fast converging and shearing motion along the PIL from HMI vector magnetograms, and recovers the observed Doppler signal much better than an old version of the algorithm. The inferred velocity vectors are largely (anti-)parallel to the inclined magnetic fields, suggesting that the observed Doppler shift contains a significant contribution from the projected field-aligned flows. High-resolution observations from the Hinode/Spectro-Polarimeter further exhibit a clear correlation between the Doppler velocity and the cosine of the magnetic inclination, which is in agreement with HMI results and consistent with a field-aligned flow of about 9.6 km s ^−1 . The complex Stokes profiles suggest significant gradients of physical variables along the line of sight. We discuss the implications on the δ -spot magnetic structure and the flow-driving mechanism.

We investigate the cross-calibration of the Hinode/Solar Optical Telescope-Spectro-Polarimeter (SOT-SP) and Solar Dynamics Observatory/Helioseismic and Magnetic Imager (SDO/HMI) instrument metadata, specifically the correspondence of the scaling and pointing information. Accurate calibration of these data sets gives the correspondence needed by interinstrument studies and learning-based magnetogram systems, and is required for physically meaningful photospheric magnetic field vectors. We approach the problem by robustly fitting geometric models on correspondences between images from each instrument’s pipeline. This technique is common in computer vision, but several critical details are required when using scanning-slit spectrograph data like Hinode/SOT-SP. We apply this technique to data spanning a decade of the Hinode mission. Our results suggest corrections to the published Level 2 Hinode/SOT-SP data. First, an analysis on approximately 2700 scans suggests that the reported pixel size in Hinode/SOT-SP Level 2 data is incorrect by around 1%. Second, analysis of over 12,000 scans shows that the pointing information is often incorrect by dozens of arcseconds with a strong bias. Regression of these corrections indicates that thermal effects have caused secular and cyclic drift in Hinode/SOT-SP pointing data over its mission. We offer two solutions. First, direct coalignment with SDO/HMI data via our procedure can improve alignments for many Hinode/SOT-SP scans. Second, since the pointing errors are predictable, simple post-hoc corrections can substantially improve the pointing. We conclude by illustrating the impact of this updated calibration on derived physical data products needed for research and interpretation. Among other things, our results suggest that the pointing errors induce a hemispheric bias in estimates of radial current density.