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Abstract: The structural and elastic properties were calculated using ab initio plane wave pseudopotential method within the generalized gradient approximation (GGA). Our results indicated that MgSe undergoes a structural phase transition from NaCl-type (B1) to FeSi-type (B28) at a pressure near to about 111GPa. The calculated elastic stiffness coefficients presented a linear behaviour versus pressure. The structural parameters and elastic constants of the fundamental ground are generally in good agreement with the available theoretical and experimental data. [Copyright &y& Elsevier]

The structural parameters and hydrostatic pressure coefficients of CdSxTe1-x in the two phases, namely zinc-blende and NaCl as well as the transition pressures from zinc-blende to NaCl structures at various S concentrations are presented. The calculations are performed using the full potential linearized augmented plane wave (FP-LAPW) method within the density functional theory (DFT) in the local density approximation (LDA), and two developed refinements, namely the generalized gradient approximation (GGA) of Perdew et al. for the structural properties and Engel-Vosko for the band structure calculations. Detailed comparisons are made with published experimental and theoretical data and show generally good agreement. The present results regarding the studied quantities for compositions x in the 0–1 range (0 < x < 1) and for the NaCl phase are predictions and may serve as a reference for experimental work. [ABSTRACT FROM AUTHOR]

Abstract: The elastic constants and related properties of zinc-blende Al x In1−x P y Sb1−y and Al x Ga1−x P y Sb1−y quaternary semiconductor alloys lattice matched to InAs substrate are obtained for various aluminium concentrations over the range 0–1 using the pseudopotential method within the virtual crystal approximation combined with the Harrison bond–orbital model. The agreement between our results and published experimental data, which are only available for binary parent compounds, is generally satisfactory, while our calculated results for quaternaries of interest are predictions. Except for the internal strain parameter, all studied quantities are found to exhibit the same qualitative behavior with respect to the composition x when replacing the indium (In) by the gallium (Ga). The numerically calculated results provide more opportunities to obtain diverse elastic properties while still controlling the composition components. [Copyright &y& Elsevier]

STUDY OBJECTIVE: The Vesta project aims to assess the role of traffic related air pollution in the occurrence of childhood asthma. DESIGN AND SETTING: Case-control study conducted in five French metropolitan areas between 1998 and 2000. A set of 217 pairs of matched 4 to 14 years old cases and controls were investigated. An index of lifelong exposure to traffic exhausts was constructed, using retrospective information on traffic density close to all home and school addresses since birth; this index was also calculated for the 0-3 years age period to investigate the effect of early exposures. MAIN RESULTS: Adjusted on environmental tobacco smoke, personal and parental allergy, and several confounders, lifelong exposure was not associated with asthma. In contrast, associations before age of 3 were significant: odds ratios for tertiles 2 and 3 of the exposure index, relative to tertile 1, exhibited a positive trend (1.48 (95%CI = 0.7 to 3.0) and 2.28 (1.1 to 4.6)), with greater odds ratios among subjects with positive skin prick tests. CONCLUSIONS: These results suggest that traffic related pollutants might have contributed to the asthma epidemic that has taken place during the past decades among children. [ABSTRACT FROM AUTHOR]

The first complete estimation of the compressible energy cascade rate |ϵC| at magnetohydrodynamic (MHD) and subion scales is obtained in Earth's magnetosheath using Magnetospheric MultiScale spacecraft data and an exact law derived recently for compressible Hall MHD turbulence. A multispacecraft technique is used to compute the velocity and magnetic gradients, and then all the correlation functions involved in the exact relation. It is shown that when the density fluctuations are relatively small, |ϵC| identifies well with its incompressible analog |ϵI| at MHD scales but becomes much larger than |ϵI| at subion scales. For larger density fluctuations, |ϵC| is larger than |ϵI| at every scale with a value significantly higher than for smaller density fluctuations. Our study reveals also that for both small and large density fluctuations, the nonflux terms remain always negligible with respect to the flux terms and that the major contribution to |ϵC| at subion scales comes from the compressible Hall flux. [ABSTRACT FROM AUTHOR]

The first estimation of the energy cascade rate |εC| of magnetosheath turbulence is obtained using the Cluster and THEMIS spacecraft data and an exact law of compressible isothermal magnetohydrodynamics turbulence. The mean value of |εC| is found to be close to 10-13 J m-3 s-1, at least 2 orders of magnitude larger than its value in the solar wind (~ 10-16 J m-3 s-1 in the fast wind). Two types of turbulence are evidenced and shown to be dominated either by incompressible Alfvénic or compressible magnetosoniclike fluctuations. Density fluctuations are shown to amplify the cascade rate and its spatial anisotropy in comparison with incompressible Alfvénic turbulence. Furthermore, for compressible magnetosonic fluctuations, large cascade rates are found to lie mostly near the linear kinetic instability of the mirror mode. New empirical power-laws relating |εC| to the turbulent Mach number and to the internal energy are evidenced. These new findings have potential applications in distant astrophysical plasmas that are not accessible to in situ measurements. [ABSTRACT FROM AUTHOR]

The role of supersonic turbulence in structuring the interstellar medium (ISM) remains an unsettled question. Here, this problem is investigated using a new exact law of compressible isothermal hydrodynamic turbulence, which involves two-point correlations in physical space. The new law is shown to have a compact expression that contains a single flux term reminiscent of the incompressible case and a source term with a simple expression whose sign is given by the divergence of the velocity. The law is then used to investigate the properties of such a turbulence at integral Mach number 4 produced by a massive numerical simulation with a grid resolution of points. The flux (resp. source) term was found to have positive (resp. negative) contribution to the total energy cascade rate, which is interpreted as a direct cascade amplified by compression, while their sum is constant in the inertial range. Using a local (in space) analysis it is shown that the source is mainly driven by filamentary structures in which the flux is negligible. Taking positive defined correlations reveals the existence of different turbulent regimes separated by the sonic scale, which determines the scale over which the nonnegligible source modifies the scaling of the flux. Our study provides new insight into the dynamics and structures of supersonic interstellar turbulence. [ABSTRACT FROM AUTHOR]

The exact law for fully developed homogeneous compressible magnetohydrodynamics (CMHD) turbulence is derived. For an isothermal plasma, without the assumption of isotropy, the exact law is expressed as a function of the plasma velocity field, the compressible Alfvén velocity, and the scalar density, instead of the Elsasser variables used in previous works. The theoretical results show four different types of terms that are involved in the nonlinear cascade of the total energy in the inertial range. Each category is examined in detail, in particular, those that can be written either as source or flux terms. Finally, the role of the background magnetic field B0 is highlighted and a comparison with the incompressible MHD (IMHD) model is discussed. This point is particularly important when testing this exact law on numerical simulations and in situ observations in space plasmas. [ABSTRACT FROM AUTHOR]

A response from the authors of the study "Evidence of a Cascade and Dissipation of Solar-Wind Turbulence at the Electron Gyroscale" in the 2009 issue is presented.

The article discusses a study which evaluates the effectiveness of monoclonal antibody, omalizumab, in monozygotic twin sisters with severe allergic asthma. The study demonstrated that treatment with omalizumab produced progressive improvement in respiratory function in the sisters. The results suggest that the beneficial effects of treatment with omalizumab in severe allergic asthma on respiratory function when there is a strong allergic phenotype.

Turbulence is ubiquitous in the solar wind. Turbulence causes kinetic and magnetic energy to cascade to small scales where they are eventually dissipated, adding heat to the plasma. The details of how this occurs are not well understood. This article reviews the evidence for turbulent dissipation and examines various diagnostics for identifying solar wind regions where dissipation is occurring. We also discuss how future missions will further enhance our understanding of the importance of turbulence to solar wind dynamics. [ABSTRACT FROM AUTHOR]

An ion‐scale flux rope (FR), embedded in a high‐speed electron flow (possibly an electron vortex), is investigated in the magnetotail using observations from the Magnetospheric Multiscale (MMS) spacecraft. Intense electric field and current and abundant waves are observed in the exterior and interior regions of the FR. Comparable parallel and perpendicular currents in the interior region imply that the FR has a non‐force‐free configuration. Electron demagnetization occurs in some subregions of the FR. It is surprising that strong dissipation (J × E' up to 2,000 pW/m3) occurs in the center of the FR without signatures of secondary reconnection or coalescence of two FRs, implying that FR may provide another important channel for energy dissipation in space plasmas. These features indicate that the observed FR is still highly dynamical, and hosts multiscale coupling processes, even though the FR has a very large scale and is far away from the reconnection site. Plain Language Summary: Flux ropes, 3‐D helical magnetic structures, in which magnetic field lines twist with each other, play an important role in the macroscopic and microscopic physical process during magnetic reconnection. Most of previous studies focused on the flux ropes in the reconnection region. However, some physical process inside macroscopic flux ropes far away from the reconnection site in the magnetotail is still unclear due to the lack of high time resolution data. In this letter, thanks to the unprecedented high time resolution data of the Magnetospheric Multiscale (MMS) mission, we report an ion‐scale flux rope and study its dynamics. Our observations demonstrate that the observed flux rope is still highly dynamical, and hosting multiscale coupling processes and strong energy dissipation, even though the flux rope has very large scale and is far away from the reconnection site. Key Points: An ion‐scale flux rope, embedded in possible electron vortex, is investigated in the magnetotail in detailsElectron demagnetization occurs in some subregions of the flux rope, and abundant waves are detected in the exterior and interior regionsStrong dissipation occurs in the flux rope, implying that flux rope provides another important channel for energy dissipation in space plasma [ABSTRACT FROM AUTHOR]

We derive an exact law for three-dimensional (3D) homogeneous compressible isothermal Hall magnetohydrodynamic turbulence, without the assumption of isotropy. The Hall current is shown to introduce new flux and source terms that act at the small scales (comparable or smaller than the ion skin depth) to significantly impact the turbulence dynamics. The law provides an accurate means to estimate the energy cascade rate over a broad range of scales covering the magnetohydrodynamic inertial range and the sub-ion dispersive range in 3D numerical simulations and in in situ spacecraft observations of compressible turbulence. This work is particularly relevant to astrophysical flows in which small-scale density fluctuations cannot be ignored such as the solar wind, planetary magnetospheres, and the interstellar medium. [ABSTRACT FROM AUTHOR]

Using spatio-temporal spectra, we show direct evidence of excitation of magnetosonic and Alfvén waves in three-dimensional compressible magnetohydrodynamic turbulence at small Mach numbers. For the plasma pressure dominated regime, or the high β regime (with β the ratio between fluid and magnetic pressure), and for the magnetic pressure dominated regime, or the low β regime, we study magnetic field fluctuations parallel and perpendicular to a guide magnetic field B0. In the low β case, we find excitation of compressible and incompressible fluctuations, with a transfer of energy towards Alfvénic modes and to a lesser extent towards magnetosonic modes. In particular, we find signatures of the presence of fast magnetosonic waves in a scenario compatible with that of weak turbulence. In the high β case, fast and slow magnetosonic waves are present, with no clear trace of Alfvén waves, and a significant part of the energy is carried by two-dimensional turbulent eddies. [ABSTRACT FROM AUTHOR]

The environmental and economic impacts linked with solar systems are largely based on discharges of slurry generated during the various stages of sawing and cutting ingots. These discharges into the environment are subject to the general regulations on hazardous and special industrial waste disposal. Therefore, they should not be abandoned or burned in open air. The cutting of Silicon ingots leads to the production of Silicon wafers additional costs, losing more than 30% of Silicon material. Abrasive grains (Silicon Carbide) trapped between the wire and the block of Silicon need to be removed by various mechanisms to be later evacuated by slurry fragments. In the interest of decreasing operational costs during polycrystalline ingot slicing at Semiconductors Research Center, and, avoid environmental problems; it is necessary to recover the solar grade Silicon from the Silicon sawing waste. For this reason, the removal of metal fragments has become a preliminary requirement to regenerate the slurry; in addition, the solid phase needs to be separated from the liquid phase after the dissolution PEG with the solvent. In the present study, magnetic separation and centrifugation methods were adopted for metals removal, followed by the analysis of some operating parameters such as: washing time, pH, and initial concentration of Silicon. Finally, analytical, morphological and basic methods were performed in order to evaluate the efficiency of the process undertaken. [ABSTRACT FROM AUTHOR]

Abstract: Energy band structures under pressure of calcium selenide (CaSe) were calculated using the plane-wave pseudopotential code CASTEP. The results show a progressive transition from a direct to an indirect gap semiconductor at a pressure of about 2GPa, in the B1 phase. An insulator–conductor change was also observed at 70GPa, in the B2 phase. Concerning CaSe, these two results could not be evidenced in previous literature. Hence, our work is a first attempt in this direction. [Copyright &y& Elsevier]

Objective. – Asthma in adults is a chronic inflammatory disease characterized principally by eosinophilic infiltration. Since there are few data on BronchoAlveolar Lavage (BAL) in children with asthma, we investigated the relationship between clinical parameters (such as age, allergic sensitization and asthma severity) and differential cell counts in BAL fluid in asthmatic children.Patients and methods. – BAL fluid was obtained from 79 asthmatic infants and children (age 5 months to 18 years; 67% males). 48% of these children had allergic asthma and 43% had severe, persistent asthma. The clinical significance of the bronchoalveolar cell profiles was analyzed by multivariate analysis.Results. – The results showed that: 1) young infants have significantly more total alveolar cells, especially macrophages, compared to older children; 2) allergic asthma was associated with the presence of alveolar eosinophils; 3) severe, persistent asthma and asthma of long duration were associated with an increased number of alveolar neutrophils.Conclusion. – Our results show for the first time that alveolar eosinophilic inflammation is present in BAL fluid obtained from asthmatic babies and infants. [Copyright &y& Elsevier]

The differential heating of electrons and ions by turbulence in weakly collisional magnetized plasmas and the scales at which such energy dissipation is most effective are still debated. Using a large data sample measured in Earth's magnetosheath by the magnetospheric multiscale mission and the coarse-grained energy equations derived from the Vlasov-Maxwell system, we find evidence of a balance over two decades in scales between the energy cascade and dissipation rates. The decline of the cascade rate at kinetic scales (in contrast with a constant one in the inertial range), is balanced by an increasing ion and electron heating rates, estimated via the pressure strain. Ion scales are found to contribute most effectively to ion heating, while electron heating originates from both ion and electron scales. These results can potentially impact the current understanding of particle heating in turbulent magnetized plasmas as well as their theoretical and numerical modeling.

The interplay between plasma turbulence and magnetic reconnection remains an unsettled question in astrophysical and laboratory plasmas. Here, we report the first observational evidence that magnetic reconnection drives subion-scale turbulence in magnetospheric plasmas by transferring energy to small scales. We employ a spatial "coarse-grained" model of Hall magnetohydrodynamics, enabling us to measure the nonlinear energy transfer rate across scale ℓ at position x. Its application to Magnetospheric Multiscale mission data shows that magnetic reconnection drives intense energy transfer to subion-scales. This observational evidence is remarkably supported by the results from Hybrid Vlasov-Maxwell simulations of turbulence to which the coarse-grained model is also applied. These results can potentially answer some open questions on plasma turbulence in planetary environments.

We derive the coarse-graining (CG) equations of incompressible Hall magnetohydrodynamic (HMHD) turbulence to investigate the local (in space) energy transfer rate as a function of the filtering scale ℓ. First, the CG equations are space averaged to obtain the analytical expression of the mean cascade rate. Its application to three-dimensional simulations of (weakly compressible) HMHD shows a cascade rate consistent with the value of the mean dissipation rate in the simulations and with the classical estimates based on the "third-order" law. Furthermore, we developed an anisotropic version of CG that allows us to study the magnitude of the cascade rate along different directions with respect to the mean magnetic field. Its implementation on the numerical data with moderate background magnetic field shows a weaker cascade along the magnetic field than in the perpendicular plane, while an isotropic cascade is recovered in the absence of a background field. The strength of the CG approach is further revealed when considering the local-in-space energy transfer, which is shown theoretically and numerically to match at a given position x, when locally averaged over a neighboring region, the (quasi-)local dissipation. Prospects of exploiting this model to investigate local dissipation in spacecraft data are discussed.

We derive an exact law for compressible pressure-anisotropic magnetohydrodynamic turbulence. For a gyrotropic pressure tensor, we study the double-adiabatic case and show the presence of new flux and source terms in the exact law, reminiscent of the plasma instability conditions due to pressure anisotropy. The Hall term is shown to bring ion-scale corrections to the exact law without affecting explicitly the pressure terms. In the pressure isotropy limit we recover all known results obtained for isothermal and polytropic closures. The incompressible limit of the gyrotropic system leads to a generalization of the Politano and Pouquet's law where a new incompressible source term is revealed and reflects exchanges of the magnetic and kinetic energies with the no-longer-conserved internal energy. We highlight the possibilities offered by the new laws to investigate potential links between turbulence cascade and instabilities widely observed in laboratory and astrophysical plasmas.

The smallest characteristic scales, at which electron dynamics determines the plasma behaviour, are the next frontier in space and astrophysical plasma research. The analysis of astrophysical processes at these scales lies at the heart of the research theme of electron-astrophysics. Electron scales are the ultimate bottleneck for dissipation of plasma turbulence, which is a fundamental process not understood in the electron-kinetic regime. In addition, plasma electrons often play an important role for the spatial transfer of thermal energy due to the high heat flux associated with their velocity distribution. The regulation of this electron heat flux is likewise not understood. By focussing on these and other fundamental electron processes, the research theme of electron-astrophysics links outstanding science questions of great importance to the fields of space physics, astrophysics, and laboratory plasma physics. In this White Paper, submitted to ESA in response to the Voyage 2050 call, we review a selection of these outstanding questions, discuss their importance, and present a roadmap for answering them through novel space-mission concepts., Competing Interests: Conflicts of interest/Competing interestsNone., (© The Author(s) 2021.)

Background: Atopic dermatitis (AD) is known to predate asthma and other atopic disorders described under the term "atopic march". However, this classic sequence is not always present and only a few studies have addressed children at risk of developing asthma. The objective of this study is to define early-onset AD phenotypes leading to asthma., Methods: We performed a cluster analysis with 9 variables of 214 infants with early-onset AD prospectively enrolled in the ORCA cohort and followed each year on the occurrence of asthma until the age of 6., Results: We identified 3 clusters - cluster 1 (n = 94) with low to no sensitization to food (27.7%) or aeroallergens (10.6%) and moderate AD severity (SCORAD 25.29 +/- 14.6) called "AD with low sensitization"; - cluster 2 (n = 84) characterized by a higher AD severity (SCORAD 32.66+/-16.6) and frequent sensitization to food (98.9%) or aeroallergens (26.2%), most likely multiple (96.4% for food allergens), called "AD with multiple sensitizations" - cluster 3 (n = 36) with parental history, moderate AD severity (SCORAD 24.46+/-15.7), moderate rate of sensitization to food allergens (38.9%) (exclusively single) with no sensitization to aeroallergens, called "AD with familial history of asthma". Percentages of children suffering from asthma at the age of 6 were higher in clusters 2 and 3 (36.1% and 33.3% respectively versus 14.9% in cluster 1, p<0.01)., Conclusion: Two phenotypes in infants with early-onset AD convey a higher risk of developing asthma during childhood: multiple sensitization and familial history of asthma.

Turbulence is ubiquitous in the solar wind. Turbulence causes kinetic and magnetic energy to cascade to small scales where they are eventually dissipated, adding heat to the plasma. The details of how this occurs are not well understood. This article reviews the evidence for turbulent dissipation and examines various diagnostics for identifying solar wind regions where dissipation is occurring. We also discuss how future missions will further enhance our understanding of the importance of turbulence to solar wind dynamics., (© 2015 The Author(s) Published by the Royal Society. All rights reserved.)

Background: Early-onset atopic dermatitis (AD) is a particular phenotype that may convey a risk of developing multiple sensitizations to allergens but little is known about the pathway of sensitization. The aims of this study were to describe the natural history of sensitization to allergens for this phenotype and to identify the most predictive marker associated with the risk of developing sensitization to inhaled allergens in a well-selected cohort of infants with AD., Methods: Infants with active AD were enrolled and prospectively explored for biological markers of atopy every year until the age of 6 yr. Allergic sensitization was defined as the presence of positive specific IgEs to allergens and multiple sensitizations as being sensitized to ≥2 allergens. Elevated blood eosinophilia was defined as an eosinophil blood count ≥470 eosinophils/mm(3) and elevated total IgE as a serum IgE level ≥45 kU/l., Results: Two hundred and twenty-nine infants were included. Elevated blood eosinophilia was observed at baseline in 60 children (26.2%) and elevated total IgE in 85 (37.1%). When elevated at baseline, eosinophilia and IgE levels remained significantly higher during the follow-up period. Sensitization to food allergens decreased from 58% to 34%, whereas sensitization to inhaled allergens increased over time from 17% to 67%. Initial multiple sensitizations to food allergens were the most predictive factor for the risk of developing sensitization to inhaled allergens at 6 yr (OR 3.72 [1.68-8.30] p < 0.001)., Conclusions: In the early-onset AD phenotype, multiple sensitization to food allergens conveys a higher risk of sensitization to inhaled allergens than single sensitization., (© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)

The prevalence of cancer is not well established and probably underestimated in long-stay psychiatric inpatients. Psychiatric patients do not have the same access for cancer screening and care. Therapeutic decision-making is a real ethical problem. In this context, access to medical care should be provided by the establishment of guidelines and/or recommendations for this specific population. The aim of our study was to assess how cancer was managed among long term psychiatric inpatients. For this pilot study, we used a mixed methodology: a quantitative part with a retrospective chart review of cancer patients in a psychiatric institution and a qualitative part based on semi-structured interviews with psychiatrists with discourse analysis. Delay in cancer diagnosis can be explained by communication and behavior disorders, inadequate screening, and additional tests often refused by patients. Compliance and ethical issues (i.e. obtaining informed consent) are many pitfalls to optimal cancer care that should be explored in further research.

We show the first three dimensional (3D) dispersion relations and k spectra of magnetic turbulence in the solar wind at subproton scales. We used the Cluster data with short separations and applied the k-filtering technique to the frequency range where the transition to subproton scales occurs. We show that the cascade is carried by highly oblique kinetic Alfvén waves with ω(plas) ≤ 0.1ω(ci) down to k(⊥) ρ(i)∼2. Each k spectrum in the direction perpendicular to B0 shows two scaling ranges separated by a breakpoint (in the interval [0.4,1]k(⊥)ρ(i): a Kolmogorov scaling k(⊥)⁻¹ⁱ⁷ followed by a steeper scaling ∼k(⊥)⁻⁴ⁱ⁵. We conjecture that the turbulence undergoes a transition range, where part of the energy is dissipated into proton heating via Landau damping and the remaining energy cascades down to electron scales where electron Landau damping may predominate.

To evaluate the relationship between clinical parameters and differential cell counts, bronchoalveolar lavage was performed in 79 asthmatic infants and children with unusual asthma. Multivariate analysis showed significant associations between (1) allergic asthma and the presence of alveolar eosinophils and (2) persistent and longer asthma and an increased number of alveolar neutrophils. Our results provide the first evidence that in asthmatic infants and children eosinophilic inflammation is related to allergic sensitization.

A case-control study was conducted in five French metropolitan areas in order to assess the role of traffic-related air pollution in the occurrence of childhood asthma. This paper presents the study design and describes the distribution of key exposure variables. A set of 217 pairs of matched 4- to 14-year-old cases and controls were investigated (matching criteria: city, age, and gender). Current and past environmental smoke exposures, indoor allergens or air pollution sources, and personal and family atopy were assessed by standard questionnaires. When possible, direct measurements were done to check the validity of this information, on current data: skin prick tests, urine cotinine, house dust mites densities, personal exposures to, and home indoor concentrations of NO(x) and PM(2.5). Cumulative exposure to traffic-related pollutants was estimated through two indices: "traffic density" refers to a time-weighted average of the traffic density-to-road distance ratio for all home and school addresses of each child's life; "air pollution" index combines lifelong time-activity patterns and ambient air concentration estimates of NO(x), using an air dispersion model of traffic exhausts. Average current PM(2.5) personal exposure is 23.8 microg/m3 (SD=17.4), and average indoor concentrations=22.5 microg/m3 (18.2); corresponding values for NO(2) are 31.4 (13.9) and 36.1 (21.4) microg/m3. Average lifelong calculated exposures to traffic-related NO(x) emissions are 62.6 microg/m3 (43.1). The five cities show important contrasts of exposure to traffic pollutants. These data will allow comparison of lifelong exposures to indicators of traffic exhausts between cases and controls, including during early ages, while controlling for a host of known enhancers or precipitators of airway chronic inflammation and for possible confounders.

The prevalence of respiratory allergies has increased over the last 20 years, highlighting the need for a simple and noninvasive tool to investigate, in a clinical and epidemiological context, airway-inflammation mechanisms encountered in allergic and inflammatory processes. The nose, as the first region of the respiratory tract to come in contact with airborne pollutants, is easily explored with the use of nasal lavage (NL). We evaluated an NL method for adults and children, along with its reproducibility and capacity to separate different subgroups. NL reproducibility, assessed in 10 healthy, nonsmoking adults on three different occasions, was determined with the use of the intraclass coefficient of correlation for such inflammatory markers as total cell count, albumin, urea, neutrophil elastase, alpha(1)-antitrypsin, interleukin-6, and interleukin-8. Using this NL method, we analyzed nasal markers of 50 healthy adults (smokers and nonsmokers) and 12 healthy children. Our NL method demonstrated high reproducibility with regard to total cell count, albumin, urea, and alpha(1)-antitrypsin (intraclass correlation coefficient > 0.75). Compared with NL results in nonsmokers, NL in heavy smokers revealed significant increased concentrations of total cell counts and interleukin-8 and significant decreased concentrations of interleukin-6. These findings suggest that NL can be used as a tool in the assessment of inflammation because it has the correct reproducibility and can discriminate between heavy smokers and nonsmokers. Moreover, the use of this standardized method in children is feasible.