5,728 results on '"S, Anand"'
Search Results
402. Implementing and evaluating the performance of various Machine Learning algorithms with different datasets
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V. Neethidevan and S. Anand
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General Nursing ,Education - Abstract
Machine learning algorithms are used to train the machine to learn on its own and improve from experience. It involves building the mathematical models to help in understand the data. When these models are applied with tunable parameters to the observed data. Using this program can be considered to be learning from the data. Once the models learned enough from the data given as input, they could be used for predicting and understand different features of new data. The supervised learning involves modelling the relationship between measured features of data and some label associated with data. Once the model is trained with enough data and features, then new data can be given to the model for classification purpose. It is further classified into classification tasks and regression tasks. Unsupervised learning involves modelling the features of a dataset without reference to any label, and in this based on some similarity features data are grouped into some form. The similarity features are nothing but distance between the data is very minimum. These models include tasks such as clustering and dimensionality reduction. Clustering algorithms identify distinct groups of data, while dimensionality reduction algorithms search for more simple representations of the data.
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- 2022
403. Development of a Robotic Shear Wave Elastography System for Noninvasive Staging of Liver Disease in Murine Models
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Tomasz J. Czernuszewicz, Adam M. Aji, Christopher J. Moore, Stephanie A. Montgomery, Brian Velasco, Gabriela Torres, Keerthi S. Anand, Kennita A. Johnson, Allison M. Deal, Dženan Zukić, Matthew McCormick, Bernd Schnabl, Caterina M. Gallippi, Paul A. Dayton, and Ryan C. Gessner
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Liver Cirrhosis ,Mice, Inbred C57BL ,Disease Models, Animal ,Mice ,Robotic Surgical Procedures ,Hepatology ,Non-alcoholic Fatty Liver Disease ,Animals ,Elasticity Imaging Techniques ,Reproducibility of Results ,Female - Abstract
Shear wave elastography (SWE) is an ultrasound-based stiffness quantification technology that is used for noninvasive liver fibrosis assessment. However, despite widescale clinical adoption, SWE is largely unused by preclinical researchers and drug developers for studies of liver disease progression in small animal models due to significant experimental, technical, and reproducibility challenges. Therefore, the aim of this work was to develop a tool designed specifically for assessing liver stiffness and echogenicity in small animals to better enable longitudinal preclinical studies. A high-frequency linear array transducer (12-24 MHz) was integrated into a robotic small animal ultrasound system (Vega; SonoVol, Inc., Durham, NC) to perform liver stiffness and echogenicity measurements in three dimensions. The instrument was validated with tissue-mimicking phantoms and a mouse model of nonalcoholic steatohepatitis. Female C57BL/6J mice (n = 40) were placed on choline-deficient, L-amino acid-defined, high-fat diet and imaged longitudinally for 15 weeks. A subset was sacrificed after each imaging timepoint (n = 5) for histological validation, and analyses of receiver operating characteristic (ROC) curves were performed. Results demonstrated that robotic measurements of echogenicity and stiffness were most strongly correlated with macrovesicular steatosis (R
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- 2022
404. Abstract P2-13-45: Interim results of a phase 1 study of the novel immunotoxin MT-5111 in patients with HER2+tumors
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Brian A. Van Tine, Monica Mita, Minal A. Barve, Erika P. Hamilton, Andrew J. Brenner, Frances Valdes, Daniel Ahn, Joleen Hubbard, Jason Starr, Angela Georgy, Joshua Pelham, Banmeet S. Anand, Thomas Strack, Andrés Machado Sandri, and Zev A. Wainberg
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Cancer Research ,Oncology - Abstract
Background: Engineered toxin bodies (ETBs) are composed of a de-immunized Shiga-like Toxin A subunit genetically fused to an antibody-like binding domain. ETBs can force receptor internalization, induce potent cell-kill via enzymatic and permanent inactivation of ribosomes, and may not be subject to resistance mechanisms of other therapeutics. MT-5111 is a 55 kD ETB targeting HER2 in solid tumors that binds to an epitope distinct from trastuzumab and pertuzumab, offering potential combination strategies with other HER2-targeting agents. MT-5111 may demonstrate efficacy in patients (pts) resistant to other HER2-targeting agents, as its mechanism of action does not rely on inhibition of kinase signaling or cytoskeletal or DNA damage. Methods: The primary objective is to determine the maximum tolerated dose (MTD) of MT-5111 monotherapy in adult pts with advanced HER2+ solid tumors. Secondary objectives are pharmacokinetics (PK), efficacy, and immunogenicity. Using a modified 3+3 design, the dose-escalation part of the study enrolls pts with HER2+ tumors into 7 cohorts: 0.5, 1, 2, 3, 4.5, 6.75, and 10 µg/kg/dose. Three dose-expansion cohorts will follow for HER2+ breast cancer, gastro-esophageal cancer, and other HER2+ tumors. All pts receive MT-5111 weekly as 30-min IV infusions in each 21-day treatment (tx) cycle (C) until disease progression (PD), unacceptable toxicity, death, or withdrawn consent (NCT04029922). Results: Per data cut in June 2021, 21 pts (mean age 64 years, range 34-78; 38% male) in cohorts 1-6 with breast (n=7), biliary (n=6), gastric (n=3), pancreatic (n=2), lung (n=2), and colon (n=1) cancer were treated (Table 1). Pts had a median of 4 prior lines of systemic therapies (range, 1-8) and 2 prior lines of HER2-targeting treatments (range, 0-6). No Grade (G)4 or 5 tx-emergent (TE) adverse events (AEs) occurred. Tx-related AEs occurred in 11 (52%) pts; the most common was fatigue (n=7, 33%). One pt (4.5 µg/kg) had a possibly (per PI) related G3 serious AE (SAE) of dyspnea and hypoxia, but also lymphangitic carcinomatosis and H. influenzae infection. The other related SAE occurred in a pt (6.75 µg/kg) who had a G1 transient troponin increase without concomitant cardiac symptoms or ECG/ECHO changes. All other related AEs were ≤G2. There were no clinically significant changes in cardiac biomarkers (troponin, ECG, left ventricular ejection fraction) nor were there cases of capillary leak syndrome. Two pts (3 µg/kg and 4.5 µg/kg) had reversible G2 infusion-related reactions. Best response to date has been stable disease. AUClast data matched PK simulations based on non-human primate studies, and Cmax data at 6.75 µg/kg indicated that current in-human exposure was between the IC50 values of high and medium HER2-expressing cell lines (approximately 10-89 ng/mL). Thus, a dose of at least 10 µg/kg may be required to achieve effective exposure. To date, no dose-limiting toxicities have been observed and the 10 µg/kg/dose cohort is now accruing. Conclusions: MT-5111 was well tolerated with no clinically significant immuno- or cardiotoxicity. Dose escalation is ongoing and nearing levels expected to be required for efficacious exposure. Table 1.Metastatic HER2 status and MT-5111 treatment by cohortDose0.5 µg/kg1.0 µg/kg2.0 µg/kg3.0 µg/kg4.5 µg/kg6.75 µg/kgCohort123456Number of patients treated with MT-5111433335Metastatic HER2 2+ by IHC: ALL/BC1/11/11/01/10/04/0Metastatic HER2 3+ by IHC: ALL/BC3/12/02/12/13/01/1BC, breast cancer. Citation Format: Brian A. Van Tine, Monica Mita, Minal A. Barve, Erika P. Hamilton, Andrew J. Brenner, Frances Valdes, Daniel Ahn, Joleen Hubbard, Jason Starr, Angela Georgy, Joshua Pelham, Banmeet S. Anand, Thomas Strack, Andrés Machado Sandri, Zev A. Wainberg. Interim results of a phase 1 study of the novel immunotoxin MT-5111 in patients with HER2+tumors [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr P2-13-45.
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- 2022
405. Lossless Compression of Hyperspectral Imagery by Assimilating Decorrelation and Pre-processing with Efficient Displaying Using Multiscale HDR Approach
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A. S. Anand Swamy, A. S. Mamatha, N. Shylashree, and Vijay Nath
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Electrical and Electronic Engineering ,Computer Science Applications ,Theoretical Computer Science - Published
- 2022
406. A Systematic Review and Network Meta-Analysis of Pharmacological Treatment of Heart Failure With Reduced Ejection Fraction
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Jasper Tromp, Wouter Ouwerkerk, Dirk J. van Veldhuisen, Hans L. Hillege, A. Mark Richards, Peter van der Meer, Inder S. Anand, Carolyn S.P. Lam, Adriaan A. Voors, and Epidemiology and Data Science
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pharmacotherapy ,HF ,  ,heart failure ,HETEROGENEITY ,COMBINATION ,GUIDELINES ,Cardiology and Cardiovascular Medicine ,network meta-analysis ,THERAPIES - Abstract
OBJECTIVES This study sought to estimate and compare the aggregate treatment benefit of pharmacological therapy for heart failure (HF) with reduced ejection fraction. BACKGROUND The estimated treatment effects of various combinations of contemporary HF medical therapies are not well characterized. METHODS We performed a systematic network meta-analysis, using MEDLINE/EMBASE and the Cochrane Central Register of Controlled Trials for randomized controlled trials published between January 1987 and January 2020. We included angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, beta-blockers (BB), mineralocorticoid receptor antagonists (MRAs), digoxin, hydralazine-isosorbide dinitrate, ivabradine, angiotensin receptor-neprilysin inhibitors (ARNi), sodium glucose cotransporter-2 inhibitors (SGLT2i), vericiguat, and omecamtiv-mecarbil. The primary outcome was all-cause death. We estimated the life-years gained in 2 HF populations (BIOSTAT-CHF [BIOlogy Study to TAilored Treatment in Chronic Heart Failure] and ASIAN-HF [Asian Sudden Cardiac Death in Heart Failure Registry]). RESULTS We identified 75 relevant trials representing 95,444 participants. A combination of ARNi, BB, MRA, and SGLT2i was most effective in reducing all-cause death (HR: 0.39; 95% CI: 0.31-0.49); followed by ARNi, BB, MRA, and vericiguat (HR: 0.41; 95% CI: 0.32-0.53); and ARNi, BB, and MRA (HR: 0.44; 95% CI: 0.36-0.54). Results were similar for the composite outcome of cardiovascular death or first hospitalization for HF (HR: 0.36; 95% CI: 0.29-0.46 for ARNi, BB, MRA, and SGLT2i; HR: 0.44; 95% CI: 0.35-0.56 for ARNi, BB, MRA, and omecamtiv-mecarbil; and HR: 0.43; 95% CI: 0.34-0.55 for ARNi, BB, MRA, and vericiguat). The estimated additional number of life-years gained for a 70-year-old patient on ARNi, BB, MRA, and SGLT2i was 5.0 years (2.5-7.5 years) compared with no treatment in secondary analyses. CONCLUSIONS In patients with HF with reduced ejection fraction, the estimated aggregate benefit is greatest for a combination of ARNi, BB, MRA, and SGLT2i. (J Am Coll Cardiol HF 2022;10:73-84) (c) 2022 by the American College of Cardiology Foundation.
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- 2022
407. Dose-limiting, adverse event-associated bradycardia with β-blocker treatment of atrial fibrillation in the GENETIC-AF trial
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Michiel Rienstra, Debra Marshall, William T. Abraham, Michel White, Ian A. Carroll, Sophia P. Huebler, Ryan Aleong, Dirk J. van Veldhuisen, Stephen B. Wilton, William H. Sauer, Stuart J. Connolly, Jonathan P. Piccini, Inder S. Anand, Christopher M. O'Connor, Jeff S. Healey, Christopher Dufton, Michael R. Bristow, and Cardiovascular Centre (CVC)
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Bradycardia ,medicine.medical_specialty ,business.industry ,Bucindolol ,Atrial fibrillation ,medicine.disease ,chemistry.chemical_compound ,chemistry ,Heart failure ,Internal medicine ,Heart rate ,Cardiology ,cardiovascular system ,Medicine ,Sinus rhythm ,cardiovascular diseases ,Electrical conduction system of the heart ,medicine.symptom ,business ,Metoprolol ,medicine.drug ,circulatory and respiratory physiology - Abstract
Background: Heart failure (HF) patients with atrial fibrillation (AF) often have conduction system disorders, which may be worsened by β-blocker therapy.Objective: In a post hoc analysis we examined the prevalence of bradycardia and its association with adverse events (AEs) and failure to achieve target dose in the GENETIC-AF trial.Methods: Patients randomized to metoprolol (n = 125) or bucindolol (n = 131) entering 24-week efficacy follow-up and receiving study medication were evaluated. Bradycardia was defined as an electrocardiogram (ECG) heart rate (HR) Results: Mean HR in sinus rhythm (SR) was 62.6 ± 12.5 bpm for metoprolol and 68.3 ± 11.1 bpm for bucindolol (P < .0001), but in AF HRs were not different (87.5 bpm vs 89.7 bpm, respectively). Episodes per patient for bucindolol vs metoprolol were 0.82 vs 2.08 (P < .001) for bradycardia and 0.24 vs 0.57 for severe bradycardia (P < .001), with 98.9% of the episodes occurring in SR. Patients experiencing bradycardia had a 4.15-fold higher prevalence of study medication dose reduction (P Conclusion: In AF-prone HF patients bradycardia may limit the effectiveness of β blockers, and this property is agent-dependent.
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- 2022
408. Erratum: 'A Gravitational-wave Measurement of the Hubble Constant Following the Second Observing Run of Advanced LIGO and Virgo' (2021, ApJ, 909, 218)
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B. P. Abbott, R. Abbott, T. D. Abbott, S. Abraham, F. Acernese, K. Ackley, C. Adams, R. X. Adhikari, V. B. Adya, C. Affeldt, M. Agathos, K. Agatsuma, N. Aggarwal, O. D. Aguiar, L. Aiello, A. Ain, P. Ajith, G. Allen, A. Allocca, M. A. Aloy, P. A. Altin, A. Amato, S. Anand, A. Ananyeva, S. B. Anderson, W. G. Anderson, S. V. Angelova, S. Antier, S. Appert, K. Arai, M. C. Araya, J. S. Areeda, M. Arène, N. Arnaud, S. M. Aronson, K. G. Arun, S. Ascenzi, G. Ashton, S. M. Aston, P. Astone, F. Aubin, P. Aufmuth, K. AultONeal, C. Austin, V. Avendano, A. Avila-Alvarez, S. Babak, P. Bacon, F. Badaracco, M. K. M. Bader, S. Bae, J. Baird, P. T. Baker, F. Baldaccini, G. Ballardin, S. W. Ballmer, A. Bals, S. Banagiri, J. C. Barayoga, C. Barbieri, S. E. Barclay, B. C. Barish, D. Barker, K. Barkett, S. Barnum, F. Barone, B. Barr, L. Barsotti, M. Barsuglia, D. Barta, J. Bartlett, I. Bartos, R. Bassiri, A. Basti, M. Bawaj, J. C. Bayley, M. Bazzan, B. Bécsy, M. Bejger, I. Belahcene, A. S. Bell, D. Beniwal, M. G. Benjamin, B. K. Berger, G. Bergmann, S. Bernuzzi, C. P. L. Berry, D. Bersanetti, A. Bertolini, J. Betzwieser, R. Bhandare, J. Bidler, E. Biggs, I. A. Bilenko, S. A. Bilgili, G. Billingsley, I. A. Birney, O. Birnholtz, S. Biscans, M. Bischi, S. Biscoveanu, A. Bisht, M. Bitossi, M. A. Bizouard, J. K. Blackburn, J. Blackman, C. D. Blair, D. G. Blair, R. M. Blair, S. Bloemen, F. Bobba, N. Bode, M. Boer, Y. Boetzel, G. Bogaert, F. Bondu, R. Bonnand, P. Booker, B. A. Boom, R. Bork, V. Boschi, S. Bose, V. Bossilkov, J. Bosveld, Y. Bouffanais, A. Bozzi, C. Bradaschia, P. R. Brady, A. Bramley, M. Branchesi, J. E. Brau, M. Breschi, T. Briant, J. H. Briggs, F. Brighenti, A. Brillet, M. Brinkmann, P. Brockill, A. F. Brooks, J. Brooks, D. D. Brown, S. Brunett, A. Buikema, T. Bulik, H. J. Bulten, A. Buonanno, D. Buskulic, C. Buy, R. L. Byer, M. Cabero, L. Cadonati, G. Cagnoli, C. Cahillane, J. Calderón Bustillo, T. A. Callister, E. Calloni, J. B. Camp, W. A. Campbell, M. Canepa, K. C. Cannon, H. Cao, J. Cao, G. Carapella, F. Carbognani, S. Caride, M. F. Carney, G. Carullo, J. Casanueva Diaz, C. Casentini, S. Caudill, M. Cavaglià, F. Cavalier, R. Cavalieri, G. Cella, P. Cerdá-Durán, E. Cesarini, O. Chaibi, K. Chakravarti, S. J. Chamberlin, M. Chan, S. Chao, P. Charlton, E. A. Chase, E. Chassande-Mottin, D. Chatterjee, M. Chaturvedi, B. D. Cheeseboro, H. Y. Chen, X. Chen, Y. Chen, H.-P. Cheng, C. K. Cheong, H. Y. Chia, F. Chiadini, A. Chincarini, A. Chiummo, G. Cho, H. S. Cho, M. Cho, N. Christensen, Q. Chu, S. Chua, K. W. Chung, S. Chung, G. Ciani, M. Cieślar, A. A. Ciobanu, R. Ciolfi, F. Cipriano, A. Cirone, F. Clara, J. A. Clark, P. Clearwater, F. Cleva, E. Coccia, P.-F. Cohadon, D. Cohen, M. Colleoni, C. G. Collette, C. Collins, M. Colpi, L. R. Cominsky, M. Constancio Jr., L. Conti, S. J. Cooper, P. Corban, T. R. Corbitt, I. Cordero-Carrión, S. Corezzi, K. R. Corley, N. Cornish, D. Corre, A. Corsi, S. Cortese, C. A. Costa, R. Cotesta, M. W. Coughlin, S. B. Coughlin, J.-P. Coulon, S. T. Countryman, P. Couvares, P. B. Covas, E. E. Cowan, D. M. Coward, M. J. Cowart, D. C. Coyne, R. Coyne, J. D. E. Creighton, T. D. Creighton, J. Cripe, M. Croquette, S. G. Crowder, T. J. Cullen, A. Cumming, L. Cunningham, E. Cuoco, T. Dal Canton, G. Dálya, B. D’Angelo, S. L. Danilishin, S. D’Antonio, K. Danzmann, A. Dasgupta, C. F. Da Silva Costa, L. E. H. Datrier, V. Dattilo, I. Dave, M. Davier, D. Davis, E. J. Daw, D. DeBra, M. Deenadayalan, J. Degallaix, M. De Laurentis, S. Deléglise, W. Del Pozzo, L. M. DeMarchi, N. Demos, T. Dent, R. De Pietri, R. De Rosa, C. De Rossi, R. DeSalvo, O. de Varona, S. Dhurandhar, M. C. Díaz, T. Dietrich, L. Di Fiore, C. DiFronzo, C. Di Giorgio, F. Di Giovanni, M. Di Giovanni, T. Di Girolamo, A. Di Lieto, B. Ding, S. Di Pace, I. Di Palma, F. Di Renzo, A. K. Divakarla, A. Dmitriev, Z. Doctor, F. Donovan, K. L. Dooley, S. Doravari, I. Dorrington, T. P. Downes, M. Drago, J. C. Driggers, Z. Du, J.-G. Ducoin, P. Dupej, O. Durante, S. E. Dwyer, P. J. Easter, G. Eddolls, T. B. Edo, A. Effler, P. Ehrens, J. Eichholz, S. S. Eikenberry, M. Eisenmann, R. A. Eisenstein, L. Errico, R. C. Essick, H. Estelles, D. Estevez, Z. B. Etienne, T. Etzel, M. Evans, T. M. Evans, V. Fafone, S. Fairhurst, X. Fan, S. Farinon, B. Farr, W. M. Farr, E. J. Fauchon-Jones, M. Favata, M. Fays, M. Fazio, C. Fee, J. Feicht, M. M. Fejer, F. Feng, A. Fernandez-Galiana, I. Ferrante, E. C. Ferreira, T. A. Ferreira, F. Fidecaro, I. Fiori, D. Fiorucci, M. Fishbach, R. P. Fisher, J. M. Fishner, R. Fittipaldi, M. Fitz-Axen, V. Fiumara, R. Flaminio, M. Fletcher, E. Floden, E. Flynn, H. Fong, J. A. Font, P. W. F. Forsyth, J.-D. Fournier, Francisco Hernandez Vivanco, S. Frasca, F. Frasconi, Z. Frei, A. Freise, R. Frey, V. Frey, P. Fritschel, V. V. Frolov, G. Fronzè, P. Fulda, M. Fyffe, H. A. Gabbard, B. U. Gadre, S. M. Gaebel, J. R. Gair, L. Gammaitoni, S. G. Gaonkar, C. García-Quirós, F. Garufi, B. Gateley, S. Gaudio, G. Gaur, V. Gayathri, G. Gemme, E. Genin, A. Gennai, D. George, J. George, L. Gergely, S. Ghonge, Abhirup Ghosh, Archisman Ghosh, S. Ghosh, B. Giacomazzo, J. A. Giaime, K. D. Giardina, D. R. Gibson, K. Gill, L. Glover, J. Gniesmer, P. Godwin, E. Goetz, R. Goetz, B. Goncharov, G. González, J. M. Gonzalez Castro, A. Gopakumar, S. E. Gossan, M. Gosselin, R. Gouaty, B. Grace, A. Grado, M. Granata, A. Grant, S. Gras, P. Grassia, C. Gray, R. Gray, G. Greco, A. C. Green, R. Green, E. M. Gretarsson, A. Grimaldi, S. J. Grimm, P. Groot, H. Grote, S. Grunewald, P. Gruning, G. M. Guidi, H. K. Gulati, Y. Guo, A. Gupta, Anchal Gupta, P. Gupta, E. K. Gustafson, R. Gustafson, L. Haegel, O. Halim, B. R. Hall, E. D. Hall, E. Z. Hamilton, G. Hammond, M. Haney, M. M. Hanke, J. Hanks, C. Hanna, M. D. Hannam, O. A. Hannuksela, T. J. Hansen, J. Hanson, T. Harder, T. Hardwick, K. Haris, J. Harms, G. M. Harry, I. W. Harry, R. K. Hasskew, C. J. Haster, K. Haughian, F. J. Hayes, J. Healy, A. Heidmann, M. C. Heintze, H. Heitmann, F. Hellman, P. Hello, G. Hemming, M. Hendry, I. S. Heng, J. Hennig, M. Heurs, S. Hild, T. Hinderer, S. Hochheim, D. Hofman, A. M. Holgado, N. A. Holland, K. Holt, D. E. Holz, P. Hopkins, C. Horst, J. Hough, E. J. Howell, C. G. Hoy, Y. Huang, M. T. Hübner, E. A. Huerta, D. Huet, B. Hughey, V. Hui, S. Husa, S. H. Huttner, T. Huynh-Dinh, B. Idzkowski, A. Iess, H. Inchauspe, C. Ingram, R. Inta, G. Intini, B. Irwin, H. N. Isa, J.-M. Isac, M. Isi, B. R. Iyer, T. Jacqmin, S. J. Jadhav, K. Jani, N. N. Janthalur, P. Jaranowski, D. Jariwala, A. C. Jenkins, J. Jiang, D. S. Johnson, A. W. Jones, D. I. Jones, J. D. Jones, R. Jones, R. J. G. Jonker, L. Ju, J. Junker, C. V. Kalaghatgi, V. Kalogera, B. Kamai, S. Kandhasamy, G. Kang, J. B. Kanner, S. J. Kapadia, C. Karathanasis, S. Karki, R. Kashyap, M. Kasprzack, S. Katsanevas, E. Katsavounidis, W. Katzman, S. Kaufer, K. Kawabe, N. V. Keerthana, F. Kéfélian, D. Keitel, R. Kennedy, J. S. Key, F. Y. Khalili, I. Khan, S. Khan, E. A. Khazanov, N. Khetan, M. Khursheed, N. Kijbunchoo, Chunglee Kim, J. C. Kim, K. Kim, W. Kim, W. S. Kim, Y.-M. Kim, C. Kimball, P. J. King, M. Kinley-Hanlon, R. Kirchhoff, J. S. Kissel, L. Kleybolte, J. H. Klika, S. Klimenko, T. D. Knowles, P. Koch, S. M. Koehlenbeck, G. Koekoek, S. Koley, V. Kondrashov, A. Kontos, N. Koper, M. Korobko, W. Z. Korth, M. Kovalam, D. B. Kozak, C. Krämer, V. Kringel, N. Krishnendu, A. Królak, N. Krupinski, G. Kuehn, A. Kumar, P. Kumar, Rahul Kumar, Rakesh Kumar, L. Kuo, A. Kutynia, S. Kwang, B. D. Lackey, D. Laghi, K. H. Lai, T. L. Lam, M. Landry, B. B. Lane, R. N. Lang, J. Lange, B. Lantz, R. K. Lanza, A. Lartaux-Vollard, P. D. Lasky, M. Laxen, A. Lazzarini, C. Lazzaro, P. Leaci, S. Leavey, Y. K. Lecoeuche, C. H. Lee, H. K. Lee, H. M. Lee, H. W. Lee, J. Lee, K. Lee, J. Lehmann, A. K. Lenon, N. Leroy, N. Letendre, Y. Levin, A. Li, J. Li, K. J. L. Li, T. G. F. Li, X. Li, F. Lin, F. Linde, S. D. Linker, T. B. Littenberg, J. Liu, X. Liu, M. Llorens-Monteagudo, R. K. L. Lo, L. T. London, A. Longo, M. Lorenzini, V. Loriette, M. Lormand, G. Losurdo, J. D. Lough, C. O. Lousto, G. Lovelace, M. E. Lower, H. Lück, D. Lumaca, A. P. Lundgren, R. Lynch, Y. Ma, R. Macas, S. Macfoy, M. MacInnis, D. M. Macleod, A. Macquet, I. Magaña Hernandez, F. Magaña-Sandoval, R. M. Magee, E. Majorana, I. Maksimovic, A. Malik, N. Man, V. Mandic, V. Mangano, G. L. Mansell, M. Manske, M. Mantovani, M. Mapelli, F. Marchesoni, F. Marion, S. Márka, Z. Márka, C. Markakis, A. S. Markosyan, A. Markowitz, E. Maros, A. Marquina, S. Marsat, F. Martelli, I. W. Martin, R. M. Martin, V. Martinez, D. V. Martynov, H. Masalehdan, K. Mason, E. Massera, A. Masserot, T. J. Massinger, M. Masso-Reid, S. Mastrogiovanni, A. Matas, F. Matichard, L. Matone, N. Mavalvala, J. J. McCann, R. McCarthy, D. E. McClelland, S. McCormick, L. McCuller, S. C. McGuire, C. McIsaac, J. McIver, D. J. McManus, T. McRae, S. T. McWilliams, D. Meacher, G. D. Meadors, M. Mehmet, A. K. Mehta, J. Meidam, E. Mejuto Villa, A. Melatos, G. Mendell, R. A. Mercer, L. Mereni, K. Merfeld, E. L. Merilh, M. Merzougui, S. Meshkov, C. Messenger, C. Messick, F. Messina, R. Metzdorff, P. M. Meyers, F. Meylahn, A. Miani, H. Miao, C. Michel, H. Middleton, L. Milano, A. L. Miller, M. Millhouse, J. C. Mills, M. C. Milovich-Goff, O. Minazzoli, Y. Minenkov, A. Mishkin, C. Mishra, T. Mistry, S. Mitra, V. P. Mitrofanov, G. Mitselmakher, R. Mittleman, G. Mo, D. Moffa, K. Mogushi, S. R. P. Mohapatra, M. Molina-Ruiz, M. Mondin, M. Montani, C. J. Moore, D. Moraru, F. Morawski, G. Moreno, S. Morisaki, B. Mours, C. M. Mow-Lowry, F. Muciaccia, Arunava Mukherjee, D. Mukherjee, S. Mukherjee, Subroto Mukherjee, N. Mukund, A. Mullavey, J. Munch, E. A. Muñiz, M. Muratore, P. G. Murray, A. Nagar, I. Nardecchia, L. Naticchioni, R. K. Nayak, B. F. Neil, J. Neilson, G. Nelemans, T. J. N. Nelson, M. Nery, A. Neunzert, L. Nevin, K. Y. Ng, S. Ng, C. Nguyen, P. Nguyen, D. Nichols, S. A. Nichols, S. Nissanke, F. Nocera, C. North, L. K. Nuttall, M. Obergaulinger, J. Oberling, B. D. O’Brien, G. Oganesyan, G. H. Ogin, J. J. Oh, S. H. Oh, F. Ohme, H. Ohta, M. A. Okada, M. Oliver, P. Oppermann, Richard J. Oram, B. O’Reilly, R. G. Ormiston, L. F. Ortega, R. O’Shaughnessy, S. Ossokine, D. J. Ottaway, H. Overmier, B. J. Owen, A. E. Pace, G. Pagano, M. A. Page, G. Pagliaroli, A. Pai, S. A. Pai, J. R. Palamos, O. Palashov, C. Palomba, H. Pan, P. K. Panda, P. T. H. Pang, C. Pankow, F. Pannarale, B. C. Pant, F. Paoletti, A. Paoli, A. Parida, W. Parker, D. Pascucci, A. Pasqualetti, R. Passaquieti, D. Passuello, M. Patil, B. Patricelli, E. Payne, B. L. Pearlstone, T. C. Pechsiri, A. J. Pedersen, M. Pedraza, R. Pedurand, A. Pele, S. Penn, A. Perego, C. J. Perez, C. Périgois, A. Perreca, J. Petermann, H. P. Pfeiffer, M. Phelps, K. S. Phukon, O. J. Piccinni, M. Pichot, F. Piergiovanni, V. Pierro, G. Pillant, L. Pinard, I. M. Pinto, M. Pirello, M. Pitkin, W. Plastino, R. Poggiani, D. Y. T. Pong, S. Ponrathnam, P. Popolizio, E. K. Porter, J. Powell, A. K. Prajapati, J. Prasad, K. Prasai, R. Prasanna, G. Pratten, T. Prestegard, M. Principe, G. A. Prodi, L. Prokhorov, M. Punturo, P. Puppo, M. Pürrer, H. Qi, V. Quetschke, P. J. Quinonez, F. J. Raab, G. Raaijmakers, H. Radkins, N. Radulesco, P. Raffai, S. Raja, C. Rajan, B. Rajbhandari, M. Rakhmanov, K. E. Ramirez, A. Ramos-Buades, Javed Rana, K. Rao, P. Rapagnani, V. Raymond, M. Razzano, J. Read, T. Regimbau, L. Rei, S. Reid, D. H. Reitze, P. Rettegno, F. Ricci, C. J. Richardson, J. W. Richardson, P. M. Ricker, G. Riemenschneider, K. Riles, M. Rizzo, N. A. Robertson, F. Robinet, A. Rocchi, L. Rolland, J. G. Rollins, V. J. Roma, M. Romanelli, J. Romano, R. Romano, C. L. Romel, J. H. Romie, C. A. Rose, D. Rose, K. Rose, D. Rosińska, S. G. Rosofsky, M. P. Ross, S. Rowan, A. Rüdiger, P. Ruggi, G. Rutins, K. Ryan, S. Sachdev, T. Sadecki, M. Sakellariadou, O. S. Salafia, L. Salconi, M. Saleem, A. Samajdar, L. Sammut, E. J. Sanchez, L. E. Sanchez, N. Sanchis-Gual, J. R. Sanders, K. A. Santiago, E. Santos, N. Sarin, B. Sassolas, B. S. Sathyaprakash, O. Sauter, R. L. Savage, P. Schale, M. Scheel, J. Scheuer, P. Schmidt, R. Schnabel, R. M. S. Schofield, A. Schönbeck, E. Schreiber, B. W. Schulte, B. F. Schutz, J. Scott, S. M. Scott, E. Seidel, D. Sellers, A. S. Sengupta, N. Sennett, D. Sentenac, V. Sequino, A. Sergeev, Y. Setyawati, D. A. Shaddock, T. Shaffer, M. S. Shahriar, M. B. Shaner, A. Sharma, P. Sharma, P. Shawhan, H. Shen, R. Shink, D. H. Shoemaker, D. M. Shoemaker, K. Shukla, S. ShyamSundar, K. Siellez, M. Sieniawska, D. Sigg, L. P. Singer, D. Singh, N. Singh, A. Singhal, A. M. Sintes, S. Sitmukhambetov, V. Skliris, B. J. J. Slagmolen, T. J. Slaven-Blair, J. R. Smith, R. J. E. Smith, S. Somala, E. J. Son, S. Soni, B. Sorazu, F. Sorrentino, T. Souradeep, E. Sowell, A. P. Spencer, M. Spera, A. K. Srivastava, V. Srivastava, K. Staats, C. Stachie, M. Standke, D. A. Steer, M. Steinke, J. Steinlechner, S. Steinlechner, D. Steinmeyer, S. P. Stevenson, D. Stocks, R. Stone, D. J. Stops, K. A. Strain, G. Stratta, S. E. Strigin, A. Strunk, R. Sturani, A. L. Stuver, V. Sudhir, T. Z. Summerscales, L. Sun, S. Sunil, A. Sur, J. Suresh, P. J. Sutton, B. L. Swinkels, M. J. Szczepańczyk, M. Tacca, S. C. Tait, C. Talbot, D. B. Tanner, D. Tao, M. Tápai, A. Tapia, J. D. Tasson, R. Taylor, R. Tenorio, L. Terkowski, M. Thomas, P. Thomas, S. R. Thondapu, K. A. Thorne, E. Thrane, Shubhanshu Tiwari, Srishti Tiwari, V. Tiwari, K. Toland, M. Tonelli, Z. Tornasi, A. Torres-Forné, C. I. Torrie, D. Töyrä, F. Travasso, G. Traylor, M. C. Tringali, A. Tripathee, A. Trovato, L. Trozzo, K. W. Tsang, M. Tse, R. Tso, L. Tsukada, D. Tsuna, T. Tsutsui, D. Tuyenbayev, K. Ueno, D. Ugolini, C. S. Unnikrishnan, A. L. Urban, S. A. Usman, H. Vahlbruch, G. Vajente, G. Valdes, M. Valentini, N. van Bakel, M. van Beuzekom, J. F. J. van den Brand, C. Van Den Broeck, D. C. Vander-Hyde, L. van der Schaaf, J. V. VanHeijningen, A. A. van Veggel, M. Vardaro, V. Varma, S. Vass, M. Vasúth, A. Vecchio, G. Vedovato, J. Veitch, P. J. Veitch, K. Venkateswara, G. Venugopalan, D. Verkindt, F. Vetrano, A. Viceré, A. D. Viets, S. Vinciguerra, D. J. Vine, J.-Y. Vinet, S. Vitale, T. Vo, H. Vocca, C. Vorvick, S. P. Vyatchanin, A. R. Wade, L. E. Wade, M. Wade, R. Walet, M. Walker, L. Wallace, S. Walsh, H. Wang, J. Z. Wang, S. Wang, W. H. Wang, Y. F. Wang, R. L. Ward, Z. A. Warden, J. Warner, M. Was, J. Watchi, B. Weaver, L.-W. Wei, M. Weinert, A. J. Weinstein, R. Weiss, F. Wellmann, L. Wen, E. K. Wessel, P. Weßels, J. W. Westhouse, K. Wette, J. T. Whelan, B. F. Whiting, C. Whittle, D. M. Wilken, D. Williams, A. R. Williamson, J. L. Willis, B. Willke, W. Winkler, C. C. Wipf, H. Wittel, G. Woan, J. Woehler, J. K. Wofford, J. L. Wright, D. S. Wu, D. M. Wysocki, S. Xiao, R. Xu, H. Yamamoto, C. C. Yancey, L. Yang, Y. Yang, Z. Yang, M. J. Yap, M. Yazback, D. W. Yeeles, Hang Yu, Haocun Yu, S. H. R. Yuen, A. K. Zadrożny, A. Zadrożny, M. Zanolin, T. Zelenova, J.-P. Zendri, M. Zevin, J. Zhang, L. Zhang, T. Zhang, C. Zhao, G. Zhao, M. Zhou, Z. Zhou, X. J. Zhu, A. B. Zimmerman, M. E. Zucker, J. Zweizig, and The LIGO Scientific Collaboration and the Virgo Collaboration
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Astrophysics ,QB460-466 - Published
- 2021
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409. SN 2019yvq Does Not Conform to SN Ia Explosion Models
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M. A. Tucker, C. Ashall, B. J. Shappee, P. J. Vallely, C. S. Kochanek, M. E. Huber, G. S. Anand, J. V. Keane, E. Y. Hsiao, and T. W.-S. Holoien
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- 2021
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410. The Space Omics and Medical Atlas (SOMA) and international astronaut biobank
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Overbey, Eliah G., Kim, JangKeun, Tierney, Braden T., Park, Jiwoon, Houerbi, Nadia, Lucaci, Alexander G., Garcia Medina, Sebastian, Damle, Namita, Najjar, Deena, Grigorev, Kirill, Afshin, Evan E., Ryon, Krista A., Sienkiewicz, Karolina, Patras, Laura, Klotz, Remi, Ortiz, Veronica, MacKay, Matthew, Schweickart, Annalise, Chin, Christopher R., Sierra, Maria A., Valenzuela, Matias F., Dantas, Ezequiel, Nelson, Theodore M., Cekanaviciute, Egle, Deards, Gabriel, Foox, Jonathan, Narayanan, S. Anand, Schmidt, Caleb M., Schmidt, Michael A., Schmidt, Julian C., Mullane, Sean, Tigchelaar, Seth Stravers, Levitte, Steven, Westover, Craig, Bhattacharya, Chandrima, Lucotti, Serena, Wain Hirschberg, Jeremy, Proszynski, Jacqueline, Burke, Marissa, Kleinman, Ashley S., Butler, Daniel J., Loy, Conor, Mzava, Omary, Lenz, Joan, Paul, Doru, Mozsary, Christopher, Sanders, Lauren M., Taylor, Lynn E., Patel, Chintan O., Khan, Sharib A., Suhail Mohamad, Mir, Byhaqui, Syed Gufran Ahmad, Aslam, Burhan, Gajadhar, Aaron S., Williamson, Lucy, Tandel, Purvi, Yang, Qiu, Chu, Jessica, Benz, Ryan W., Siddiqui, Asim, Hornburg, Daniel, Blease, Kelly, Moreno, Juan, Boddicker, Andrew, Zhao, Junhua, Lajoie, Bryan, Scott, Ryan T., Gilbert, Rachel R., Lai Polo, San-huei, Altomare, Andrew, Kruglyak, Semyon, Levy, Shawn, Ariyapala, Ishara, Beer, Joanne, Zhang, Bingqing, Hudson, Briana M., Rininger, Aric, Church, Sarah E., Beheshti, Afshin, Church, George M., Smith, Scott M., Crucian, Brian E., Zwart, Sara R., Matei, Irina, Lyden, David C., Garrett-Bakelman, Francine, Krumsiek, Jan, Chen, Qiuying, Miller, Dawson, Shuga, Joe, Williams, Stephen, Nemec, Corey, Trudel, Guy, Pelchat, Martin, Laneuville, Odette, De Vlaminck, Iwijn, Gross, Steven, Bolton, Kelly L., Bailey, Susan M., Granstein, Richard, Furman, David, Melnick, Ari M., Costes, Sylvain V., Shirah, Bader, Yu, Min, Menon, Anil S., Mateus, Jaime, Meydan, Cem, and Mason, Christopher E.
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Spaceflight induces molecular, cellular and physiological shifts in astronauts and poses myriad biomedical challenges to the human body, which are becoming increasingly relevant as more humans venture into space1–6. Yet current frameworks for aerospace medicine are nascent and lag far behind advancements in precision medicine on Earth, underscoring the need for rapid development of space medicine databases, tools and protocols. Here we present the Space Omics and Medical Atlas (SOMA), an integrated data and sample repository for clinical, cellular and multi-omic research profiles from a diverse range of missions, including the NASA Twins Study7, JAXA CFE study8,9, SpaceX Inspiration4 crew10–12, Axiom and Polaris. The SOMA resource represents a more than tenfold increase in publicly available human space omics data, with matched samples available from the Cornell Aerospace Medicine Biobank. The Atlas includes extensive molecular and physiological profiles encompassing genomics, epigenomics, transcriptomics, proteomics, metabolomics and microbiome datasets, which reveal some consistent features across missions, including cytokine shifts, telomere elongation and gene expression changes, as well as mission-specific molecular responses and links to orthologous, tissue-specific mouse datasets. Leveraging the datasets, tools and resources in SOMA can help to accelerate precision aerospace medicine, bringing needed health monitoring, risk mitigation and countermeasure data for upcoming lunar, Mars and exploration-class missions.
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- 2024
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411. Differentiating glaucoma from chiasmal compression using optical coherence tomography: the macular naso-temporal ratio
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Kleerekooper, Iris, Wagner, Siegfried K, Trip, S Anand, Plant, Gordon T, Petzold, Axel, Keane, Pearse A, and Khawaja, Anthony P
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Background/aimsThe analysis of visual field loss patterns is clinically useful to guide differential diagnosis of visual pathway pathology. This study investigates whether a novel index of macular atrophy patterns can discriminate between chiasmal compression and glaucoma.MethodsA retrospective series of patients with preoperative chiasmal compression, primary open-angle glaucoma (POAG) and healthy controls. Macular optical coherence tomography (OCT) images were analysed for the macular ganglion cell and inner plexiform layer (mGCIPL) thickness. The nasal hemi-macula was compared with the temporal hemi-macula to derive the macular naso-temporal ratio (mNTR). Differences between groups and diagnostic accuracy were explored with multivariable linear regression and the area under the receiver operating characteristic curve (AUC).ResultsWe included 111 individuals (31 with chiasmal compression, 30 with POAG and 50 healthy controls). Compared with healthy controls, the mNTR was significantly greater in POAG cases (β=0.07, 95% CI 0.03 to 0.11, p=0.001) and lower in chiasmal compression cases (β=−0.12, 95% CI −0.16 to –0.09, p<0.001), even though overall mGCIPL thickness did not discriminate between these pathologies (p=0.36). The mNTR distinguished POAG from chiasmal compression with an AUC of 95.3% (95% CI 90% to 100%). The AUCs when comparing healthy controls to POAG and chiasmal compression were 79.0% (95% CI 68% to 90%) and 89.0% (95% CI 80% to 98%), respectively.ConclusionsThe mNTR can distinguish between chiasmal compression and POAG with high discrimination. This ratio may provide utility over-and-above previously reported sectoral thinning metrics. Incorporation of mNTR into the output of OCT instruments may aid earlier diagnosis of chiasmal compression.
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- 2024
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412. A Scheme to Verify Services with Unboundedly many Clients using NuSMV.
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S. Sheerazuddin, S. Anand, and R. S. Anish Badhri
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- 2018
413. DSS-induced colitis produces inflammation-induced bone loss while irisin treatment mitigates the inflammatory state in both gut and bone
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Metzger, Corinne E., Narayanan, S. Anand, Elizondo, Jon P., Carter, Anne Michal, Zawieja, David C., Hogan, Harry A., and Bloomfield, Susan A.
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- 2019
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414. Surface Texture and Microstructural Characterization of Thin-Walled Ti6Al4V Part Processed Using Laser Powder Bed Fusion Technique: Effect of Build Direction.
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Kumar, S. Anand, Kushwaha, Ajay, Shrivastava, Abhishek, Nagesha, B. K., and Barad, Sanjay
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Objective: The current research investigates the surface texture and microstructural characterization of thin-walled Ti6Al4V along the build direction processed using laser powder bed fusion (LPBF) technology using an intra-comparison approach. Methodology: The two-dimensional and three-dimensional surface morphology and multi-scale surface roughness analysis of all Ti6Al4V samples were performed using an opto-digital microscope (with extended focus imaging coupled with high dynamic range imaging). Moreover, the scanning electron microscope, microhardness tester, and X-ray diffraction techniques were used to analyze the microstructural and microhardness values. Findings: (1) The lath thickness was relatively thicker in the LPBF-processed Ti6Al4V sample's microstructure at central locations than in the top and bottom locations. (2) The areal surface roughness (Sa), Rk, and Sk values were relatively lower for the middle region than for the bottom and top regions of the thin-walled part, implying nonuniform surface topography along the build direction. (3) The middle region had a higher surface texture and texture amplitude symmetry periodicity than the top and bottom regions along the build direction. Value: Overall, the established methodology employed on the thin-walled Ti6Al4V part processed using LPBF technology enables the selection criteria of a suitable surface finishing process to achieve isotropic finish for practical industrial applications. [ABSTRACT FROM AUTHOR]
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- 2023
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415. Genetic influences on disease course and severity, 30 years after a clinically isolated syndrome.
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Sahi, Nitin, Haider, Lukas, Chung, Karen, Carrasco, Ferran Prados, Kanber, Baris, Samson, Rebecca, Thompson, Alan J., Wheeler-Kingshott, Claudia A. M. Gandini, Trip, S. Anand, Brownlee, Wallace, Ciccarelli, Olga, Barkhof, Frederik, Tur, Carmen, Houlden, Henry, and Chard, Declan
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- 2023
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416. Comparative Study of Polyherbal Formulation for Antiarthritic Activity Having Cockle Shell, Egg Shell, Ginger and Balloon Vein in Gel Form and Oil Form: A Novel Preparation for Anti-Oxidant Activity.
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Nithya, S., Dhanalakshmi, S., Babu, S. Anand, Nirmala, S., Bharathi, D., and Karpagavalli, L.
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ANTIOXIDANTS ,LITERATURE reviews ,GINGER ,SPECIFIC gravity ,VEINS - Abstract
Inflammatory and chronic disease of the joints and tissues surrounding them, rheumatoid arthritis is known as the most common form of arthritis. Traditional medicines plays major role because of more advantageous like lesser side effects, naturally available and cost effective. A formulation for anti arthritis activity was developed, isolated, and evaluated in this study. Based on the extensive review of the literature, we have formulated three formulation like gel, polyherbal oil formulation with extract of herbs and polyherbal formulation with powders of herbs. We have selected, traditional herbs (Cockle shell, Egg shell, Ginger and Ballon Vein) based on the literature and does a comparative study between gel and the oil formulation to check which has better anti arthritis activity. The selected herbs for formulation of gel are cockle shell and egg shell which has rich calcium content and for oil formulation herbs like ballon vein and ginger were chosen. The chemical constituent present in herbs plays a major role in curing rheumatoid arthritis. Then finally we have done a evaluation like ph measurement, spreadability, specific gravity, antioxidant study etc., between the comparison of DPPH assay of the formulation, clearly reported that the efficacy in the medicated oil in the extract and well in the macerated oil showed significant anti-oxidant activity when compared to the gel. [ABSTRACT FROM AUTHOR]
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- 2023
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417. Modified Smell Detection Algorithm for Optimal Paths Engineering in Hybrid Sdn
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Chandra S S, Vinod, primary and Hareendran S, Anand, additional
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- 2023
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418. Rationale, design, and methods for Canadian alliance for healthy hearts and minds cohort study (CAHHM) – a Pan Canadian cohort study
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Sonia S. Anand, Jack V. Tu, Philip Awadalla, Sandra Black, Catherine Boileau, David Busseuil, Dipika Desai, Jean-Pierre Després, Russell J. de Souza, Trevor Dummer, Sébastien Jacquemont, Bartha Knoppers, Eric Larose, Scott A. Lear, Francois Marcotte, Alan R. Moody, Louise Parker, Paul Poirier, Paula J. Robson, Eric E. Smith, John J. Spinelli, Jean-Claude Tardif, Koon K. Teo, Natasa Tusevljak, Matthias G. Friedrich, and on behalf of the CAHHM Study Investigators
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Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background The Canadian Alliance for Healthy Hearts and Minds (CAHHM) is a pan-Canadian, prospective, multi-ethnic cohort study being conducted in Canada. The overarching objective of the CAHHM is to understand the association of socio-environmental and contextual factors (such as societal structure, activity, nutrition, social and tobacco environments, and access to health services) with cardiovascular risk factors, subclinical vascular disease, and cardiovascular and other chronic disease outcomes. Methods/Design Participants between 35 and 69 years of age are being recruited from existing cohorts and a new First Nations Cohort to undergo a detailed assessment of health behaviours (including diet and physical activity), cognitive function, assessment of their local home and workplace environments, and their health services access and utilization. Physical measures including weight, height, waist/hip circumference, body fat percentage, and blood pressure are collected. In addition, eligible participants undergo magnetic resonance imaging (MRI) of the brain, heart, carotid artery and abdomen to detect early subclinical vascular disease and ectopic fat deposition. Discussion CAHHM is a prospective cohort study designed to investigate the impact of community level factors, individual health behaviours, and access to health services, on cognitive function, subclinical vascular disease, fat distribution, and the development of chronic diseases among adults living in Canada.
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- 2016
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419. Reviving the Ganges Water Machine: potential
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U. A. Amarasinghe, L. Muthuwatta, L. Surinaidu, S. Anand, and S. K. Jain
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Technology ,Environmental technology. Sanitary engineering ,TD1-1066 ,Geography. Anthropology. Recreation ,Environmental sciences ,GE1-350 - Abstract
The Ganges River basin faces severe water challenges related to a mismatch between supply and demand. Although the basin has abundant surface water and groundwater resources, the seasonal monsoon causes a mismatch between supply and demand as well as flooding. Water availability and flood potential is high during the 3–4 months (June–September) of the monsoon season. Yet, the highest demands occur during the 8–9 months (October–May) of the non-monsoon period. Addressing this mismatch, which is likely to increase with increasing demand, requires substantial additional storage for both flood reduction and improvements in water supply. Due to hydrogeological, environmental, and social constraints, expansion of surface storage in the Ganges River basin is problematic. A range of interventions that focus more on the use of subsurface storage (SSS), and on the acceleration of surface–subsurface water exchange, has long been known as the Ganges Water Machine (GWM). The approach of the GWM for providing such SSS is through additional pumping and depleting of the groundwater resources prior to the onset of the monsoon season and recharging the SSS through monsoon surface runoff. An important condition for creating such SSS is the degree of unmet water demand. The paper shows that the potential unmet water demand ranging from 59 to 124 Bm3 year−1 exists under two different irrigation water use scenarios: (i) to increase irrigation in the Rabi (November–March) and hot weather (April–May) seasons in India, and the Aman (July–November) and Boro (December–May) seasons in Bangladesh, to the entire irrigable area, and (ii) to provide irrigation to Rabi and the hot weather season in India and the Aman and Boro seasons in Bangladesh to the entire cropped area. However, the potential for realizing the unmet irrigation demand is high only in 7 sub-basins in the northern and eastern parts, is moderate to low in 11 sub-basins in the middle, and has little or no potential in 4 sub-basins in the western part of the Ganges basin. Overall, a revived GWM plan has the potential to meet 45–84 Bm3year−1 of unmet water demand.
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- 2016
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420. Aleukemic granulocytic sarcoma and leukemia cutis: A report of two rare cases and review of literature
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Rahul S Kulkarni, Asha S Anand, Apurva A Patel, Sandip A Shah, Harsha P Panchal, Sonia K Parikh, Hemangini H Vora, Biren P Parikh, and Avinash Talele
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6-thioguanine ,aleukemic granulocytic sarcoma ,aleukemic leukemia cutis ,chemotherapy ,lung ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Granulocytic sarcoma (GS), also called myeloid sarcoma is an extramedullary tumor of the immature granulocytic cells. It is a rare entity and mostly accompanied by acute myeloid leukemia (AML). Very rarely, it is detected before clinical signs of leukemia or other diseases. When the bone marrow biopsy reveals no other hematologic malignancies, the GS is described as aleukemic, primary or isolated. Here, we report two rare cases, one of which presented as aleukemic GS of lymph nodes with aleukemic leukemia cutis, and the other with aleukemic GS of lung. Both cases posed diagnostic dilemma in view of their atypical presentations and site of involvement. Final diagnosis was made by immunohistochemistry (IHC). Both patients were treated with standard induction chemotherapy for AML. One patient had relapsed on treatment and was further treated with only 6-thioguanine leading to complete remission. Our cases emphasize the importance of early suspicion and use of IHC in diagnosis of aleukemic GS and also potential role of oral thioguanine alone in relapsed cases not eligible for hematopoietic stem cell transplant.
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- 2016
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421. Efficacy of single-dose rasburicase in the management of tumor lysis syndrome: a case series from a regional cancer center in western India
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Sandeep R Kukkar, Harsha P Panchal, Asha S Anand, Apurva A Patel, Sonia P Parikh, and Sandip A Shah
- Subjects
Hematologic malignancy ,hyperuricemia ,single-dose rasburicase ,tumor lysis syndrome ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background: Tumor lysis syndrome (TLS) is an oncological emergency. Rasburicase (recombinant urate oxidase) has been proven to be an effective therapy for prevention of TLS and its serious consequences in patients with hematological malignancies such as acute leukemias with high white blood cells count, Burkitt lymphoma, and lymphoblastic lymphoma with high tumor burden. The US Food and Drug Administration recommended daily dosing regimen for 5 days is unaffordable by each and every patient in developing countries such as India. Recently, the conducted studies have clearly shown a similar efficacy for a single dose of rasburicase. Herein, we report a case series of 15 patients, including children and adults with hematologic malignancies, in whom TLS was managed by a single dose of rasburicase. Materials and Methods: We retrospectively analyzed the efficacy of single-dose rasburicase (SDR) (0.15 mg/kg intravenous infusion over 30 min) in patients with hematologic malignancies at risk for TLS. The drug was administered in five adult and 10 pediatric patients admitted to the Gujarat Cancer and Research Institute between January 2013 and December 2014. Results: The study included 15 patients, out of which 10 were pediatric (8 male:2 female) and five were adults (5 male:0 female). Patients with hematologic malignancies having Eastern Cooperative Oncology Group performance status 0–2 and at high risk or potential risk for TLS were selected. The median ages in pediatric and adult groups were 7.7 years and 32 years, respectively. The presence of hyperuricemia (plasma uric acid (UA) levels ≥7.5 mg/dl) or a diagnosis of very aggressive lymphoma or leukemia based on the World Health Organization classification of hematopoietic and lymphoid neoplasms in patients was classified as high-risk. Rasburicase was administered in a single dose of 0.15 mg/kg intravenously over 30 min. Patients were evaluated by clinical examination and blood biochemical tests at frequent intervals. Plasma samples for UA were collected at baseline before rasburicase, 6–24 h post-rasburicase, 48 h post-rasburicase, and daily during treatment. The blood samples for UA during the course of treatment were collected in prechilled tubes containing heparin and immediately immersed and transported on ice. The blood samples were analyzed within 4 h of collection. Serum electrolytes, blood urea nitrogen, creatinine, calcium, and phosphorous were monitored daily during this period. A single dose of rasburicase produced a rapid and sustained therapeutic effect of lowering the plasma UA levels in all the 15 patients. Renal parameters normalized within 72 h. UA levels remained below 4 mg/dl throughout the administration of chemotherapy until discharge, and none of the patients required a repeat dosing of rasburicase. Conclusion: SDR is a highly economical and clinically effective way of managing patients with TLS and could serve as an alternative to the 5-day treatment in a resource-limited country such as India.
- Published
- 2016
- Full Text
- View/download PDF
422. Spectrum Hole Identification in IEEE 802.22 WRAN using Unsupervised Learning
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V. Balaji, S. Anand, C.R. Hota, and G. Raghurama
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Cognitive radio ,Dynamic Spectrum Access ,Cooperative Sensing ,TV white space ,Machine Learning ,Technology - Abstract
In this paper we present a Cooperative Spectrum Sensing (CSS) algorithm for Cognitive Radios (CR) based on IEEE 802.22Wireless Regional Area Network (WRAN) standard. The core objective is to improve cooperative sensing efficiency which specifies how fast a decision can be reached in each round of cooperation (iteration) to sense an appropriate number of channels/bands (i.e. 86 channels of 7MHz bandwidth as per IEEE 802.22) within a time constraint (channel sensing time). To meet this objective, we have developed CSS algorithm using unsupervised K-means clustering classification approach. The received energy level of each Secondary User (SU) is considered as the parameter for determining channel availability. The performance of proposed algorithm is quantified in terms of detection accuracy, training and classification delay time. Further, the detection accuracy of our proposed scheme meets the requirement of IEEE 802.22 WRAN with the target probability of falsealrm as 0.1. All the simulations are carried out using Matlab tool.
- Published
- 2016
- Full Text
- View/download PDF
423. Electrochemical Studies of Novel X-Type Barium Hexaferrite Nanoplatelets for Supercapacitor Applications
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M. Suganya, J. Kishor Kumar, S. Anand, K. Mohamed Racik, S. Muthupandi, and S. Muniyappan
- Subjects
Condensed Matter Physics ,Electronic, Optical and Magnetic Materials - Published
- 2022
424. Serial Assessment of High-Sensitivity Cardiac Troponin and the Effect of Dapagliflozin in Patients With Heart Failure With Reduced Ejection Fraction
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Pardeep S. Jhund, Kieran F. Docherty, Marc S. Sabatine, Eileen O'Meara, Daniel Lindholm, David A. Morrow, John J.V. McMurray, Petr Jarolim, Paul Welsh, Jose C. Nicolau, Naveed Sattar, AM Langkilde, Mikhail Kosiborod, Mikaela Sjöstrand, Vijay K. Chopra, Morten Schou, Ann Hammarstedt, David D. Berg, Inder S. Anand, Rudolf A. de Boer, and Cardiovascular Centre (CVC)
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Male ,medicine.medical_specialty ,BIOMARKERS ,heart failure ,Placebo ,GUIDELINES ,Ventricular Function, Left ,Ventricular Dysfunction, Left ,chemistry.chemical_compound ,Glucosides ,Physiology (medical) ,Internal medicine ,medicine ,Clinical endpoint ,sodium-glucose transporter 2 inhibitors ,Humans ,Benzhydryl Compounds ,Dapagliflozin ,Aged ,Proportional Hazards Models ,Aged, 80 and over ,Clinical Trials as Topic ,Ejection fraction ,business.industry ,troponin ,NATRIURETIC PEPTIDE ,Hazard ratio ,Absolute risk reduction ,Stroke Volume ,clinical trial ,Middle Aged ,medicine.disease ,PROGNOSTIC VALUE ,Quartile ,chemistry ,Heart failure ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business ,Numbers Needed To Treat - Abstract
Background: Circulating high-sensitivity cardiac troponin T (hsTnT) predominantly reflects myocardial injury, and higher levels are associated with a higher risk of worsening heart failure and death in patients with heart failure with reduced ejection fraction. Less is known about the prognostic significance of changes in hsTnT over time, the effects of dapagliflozin on clinical outcomes in relation to baseline hsTnT levels, and the effect of dapagliflozin on hsTnT levels. Methods: DAPA-HF (Dapagliflozin and Prevention of Adverse Outcomes in Heart Failure) was a randomized, double-blind, placebo-controlled trial of dapagliflozin (10 mg daily) in patients with New York Heart Association class II to IV symptoms and left ventricular ejection fraction ≤40% (median follow-up, 18.2 months). hsTnT (Roche Diagnostics) was measured at baseline in 3112 patients and at 1 year in 2506 patients. The primary end point was adjudicated worsening heart failure or cardiovascular death. Clinical end points were analyzed according to baseline hsTnT and change in hsTnT from baseline to 1 year. Comparative treatment effects on clinical end points with dapagliflozin versus placebo were assessed by baseline hsTnT. The effect of dapagliflozin on hsTnT was explored. Results: Median baseline hsTnT concentration was 20.0 (25th–75th percentile, 13.7–30.2) ng/L. Over 1 year, 67.9% of patients had a ≥10% relative increase or decrease in hsTnT concentrations, and 43.5% had a ≥20% relative change. A stepwise gradient of higher risk for the primary end point was observed across increasing quartiles of baseline hsTnT concentration (adjusted hazard ratio Q4 versus Q1, 3.44 [95% CI, 2.46–4.82]). Relative and absolute increases in hsTnT over 1 year were associated with higher subsequent risk of the primary end point. The relative reduction in the primary end point with dapagliflozin was consistent across quartiles of baseline hsTnT ( P -interaction=0.55), but patients in the top quartile tended to have the greatest absolute risk reduction (absolute risk difference, 7.5% [95% CI, 1.0%–14.0%]). Dapagliflozin tended to attenuate the increase in hsTnT over time compared with placebo (relative least squares mean reduction, –3% [–6% to 0%]; P =0.076). Conclusions: Higher baseline hsTnT and greater increase in hsTnT over 1 year are associated with worse clinical outcomes. Dapagliflozin consistently reduced the risk of the primary end point, irrespective of baseline hsTnT levels. Registration: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT03036124.
- Published
- 2022
425. Planetary nebula luminosity function distances for 19 galaxies observed by PHANGS–MUSE
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Fabian Scheuermann, Kathryn Kreckel, Gagandeep S Anand, Guillermo A Blanc, Enrico Congiu, Francesco Santoro, Schuyler D Van Dyk, Ashley T Barnes, Frank Bigiel, Simon C O Glover, Brent Groves, Ralf S Klessen, J M Diederik Kruijssen, Erik Rosolowsky, Eva Schinnerer, Andreas Schruba, Elizabeth J Watkins, and Thomas G Williams
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Space and Planetary Science ,Astrophysics::High Energy Astrophysical Phenomena ,Astrophysics of Galaxies (astro-ph.GA) ,FOS: Physical sciences ,Astronomy and Astrophysics ,Astrophysics::Cosmology and Extragalactic Astrophysics ,Astrophysics - Astrophysics of Galaxies ,Astrophysics::Galaxy Astrophysics - Abstract
We provide new planetary nebula luminosity function (PNLF) distances to 19 nearby spiral galaxies that were observed with VLT/MUSE by the PHANGS collaboration. Emission line ratios are used to separate planetary nebulae (PNe) from other bright [OIII] emitting sources like compact supernovae remnants (SNRs) or HII regions. While many studies have used narrowband imaging for this purpose, the detailed spectral line information provided by integral field unit (IFU) spectroscopy grants a more robust way of categorising different [OIII] emitters. We investigate the effects of SNR contamination on the PNLF and find that we would fail to classify all objects correctly, when limited to the same data narrowband imaging provides. However, the few misclassified objects usually do not fall on the bright end of the luminosity function, and only in three cases does the distance change by more than $1\sigma$. We find generally good agreement with literature values from other methods. Using metallicity constraints that have also been derived from the same IFU data, we revisit the PNLF zero point calibration. Over a range of $8.34 < 12 + \log(\mathrm{O}/\mathrm{H}) < 8.59$, our sample is consistent with a constant zero point and yields $M^*=-4.542^{+0.103}_{-0.059}\, \mathrm{mag}$, within $1\sigma$ of other literature values. MUSE pushes the limits of PNLF studies and makes galaxies beyond $20\, \mathrm{Mpc}$ accessible for this kind of analysis. This approach to the PNLF shows great promise for leveraging existing archival IFU data on nearby galaxies., Comment: 23 pages, 31 figures. Accepted for publication in MNRAS
- Published
- 2022
426. Diabetes and pre‐diabetes in patients with heart failure and preserved ejection fraction
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Alice M, Jackson, Rasmus, Rørth, Jiankang, Liu, Søren Lund, Kristensen, Inder S, Anand, Brian L, Claggett, John G F, Cleland, Vijay K, Chopra, Akshay S, Desai, Junbo, Ge, Jianjian, Gong, Carolyn S P, Lam, Martin P, Lefkowitz, Aldo P, Maggioni, Felipe, Martinez, Milton, Packer, Marc A, Pfeffer, Burkert, Pieske, Margaret M, Redfield, Adel R, Rizkala, Jean L, Rouleau, Petar M, Seferović, Jasper, Tromp, Dirk J, Van Veldhuisen, Mehmet B, Yilmaz, Faiez, Zannad, Michael R, Zile, Lars, Køber, Mark C, Petrie, Pardeep S, Jhund, Scott D, Solomon, John J V, McMurray, and Cardiovascular Centre (CVC)
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Heart Failure ,Prediabetic State ,Natriuretic Peptide, Brain ,Diabetes Mellitus ,Humans ,Stroke Volume ,Middle Aged ,Prognosis ,Cardiology and Cardiovascular Medicine ,Peptide Fragments ,Ventricular Function, Left - Abstract
Aim: There is an association between heart failure with preserved ejection fraction (HFpEF) and insulin resistance, but less is known about the diabetic continuum, and in particular about pre-diabetes, in HFpEF. We examined characteristics and outcomes of participants with diabetes or pre-diabetes in PARAGON-HF.Methods and results: Patients aged ≥50 years with left ventricular ejection fraction ≥45%, structural heart disease and elevated N-terminal pro-B-type natriuretic peptide (NT-proBNP) were eligible. Patients were classified according to glycated haemoglobin (HbA1c): (i) normal HbA1c, Conclusion: Pre-diabetes is common in patients with HFpEF and is associated with worse clinical status and greater risk of HFH. Clinical Trial Registration: ClinicalTrials.gov Identifier NCT01920711.
- Published
- 2022
427. Anisotropic yielding performance of additively manufactured Inconel 718: Effect of thermal treatment
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Abhishek Shrivastava, S. Anand Kumar, Samrat Rao, and B.K. Nagesha
- Published
- 2022
428. Cardiac biomarkers retain prognostic significance in patients with heart failure and chronic obstructive pulmonary disease
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Kui Toh Gerard Leong, Fazlur Jaufeerally, Carolyn S.P. Lam, Kai M. Eggers, Roberto Latini, Alberto Aimo, Robert N. Doughty, Hean Yee Ong, Josep Lupón, Inder S. Anand, Giuseppe Vergaro, Kurt Huber, Ida Gustafsson, Richard W. Troughton, Yasuchika Takeishi, Michele Emdin, Tze P. Ng, Lidia Staszewsky, Claudio Passino, Antoni Bayes-Genis, Akiomi Yoshihisa, James L. Januzzi, Poh Shuan Daniel Yeo, Rudolf A. de Boer, A. Mark Richards, Hans-Peter Brunner-La Rocca, Thor Ueland, Greg D. Gamble, Cardiovascular Centre (CVC), RS: Carim - H02 Cardiomyopathy, MUMC+: MA Med Staf Spec Cardiologie (9), and Cardiologie
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Male ,medicine.medical_specialty ,medicine.drug_class ,Gastroenterology ,Severity of Illness Index ,Pulmonary Disease ,Pulmonary Disease, Chronic Obstructive ,Troponin T ,Interquartile range ,Natriuretic Peptide ,Chronic Obstructive/mortality ,Internal medicine ,Forced Expiratory Volume ,Natriuretic Peptide, Brain ,medicine ,Natriuretic peptide ,Humans ,In patient ,Aged ,Troponin T/blood ,Heart Failure ,COPD ,Ejection fraction ,Heart Failure/mortality ,business.industry ,General Medicine ,Middle Aged ,medicine.disease ,Prognosis ,Comorbidity ,Interleukin-1 Receptor-Like 1 Protein ,Peptide Fragments ,Hospitalization ,Pulmonary Disease, Chronic Obstructive/mortality ,Heart failure ,Interleukin-1 Receptor-Like 1 Protein/blood ,Female ,Natriuretic Peptide, Brain/blood ,Brain/blood ,Cardiology and Cardiovascular Medicine ,business ,Peptide Fragments/blood ,Biomarkers ,Biomarkers/blood - Abstract
AIMS: Chronic obstructive pulmonary disease (COPD) is a frequent comorbidity in patients with heart failure (HF). We assessed the influence of COPD on circulating levels and prognostic value of three HF biomarkers: N-terminal pro-B-type natriuretic peptide (NT-proBNP), high-sensitivity troponin T (hs-TnT), and soluble suppression of tumorigenesis-2 (sST2).METHODS: Individual data from patients with chronic HF, known COPD status, NT-proBNP and hs-TnT values (n = 8088) were analysed. A subgroup (n = 3414) had also sST2 values.RESULTS: Patients had a median age of 66 years (interquartile interval 57-74), 77% were men and 82% had HF with reduced ejection fraction. NT-proBNP, hs-TnT and sST2 were 1207 ng/l (487-2725), 17 ng/l (9-31) and 30 ng/ml (22-44), respectively. Patients with COPD (n = 1249, 15%) had higher NT-proBNP (P = 0.042) and hs-TnT (P CONCLUSIONS: Among patients with HF, those with COPD have higher NT-proBNP and hs-TnT, but not sST2. All these biomarkers yield prognostic significance regardless of the COPD status.
- Published
- 2022
429. A Novel GPU-Based Approach to Exploit Time-Respectingness in Public Transport Networks for Efficient Computation of Earliest Arrival Time
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Sunil Kumar Maurya and Anshu S. Anand
- Subjects
General Computer Science ,General Engineering ,General Materials Science ,Electrical and Electronic Engineering - Published
- 2022
430. Simplified Technique for Mounting the Cast in the Mean Value Articulator Using a Newly Designed Mounting Device: An Innovative Clinical Technique
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S Anand, Sonia Abraham, A Kirubakaran, VR Arun Kumar, VC Karthik, and S Nithyapriya
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General Dentistry - Published
- 2022
431. Design and optimization of a 3D printed prosthetic socket for transtibial amputees
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Piyush Rai, Venkatessan Jankiraman, Mohit Teacher, Rajkumar Velu, S. Anand Kumar, Trevor Binedell, and Karupppasamy Subburaj
- Published
- 2022
432. Battery Management System (BMS) for Electric Vehicle Applications
- Author
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S, Anand, primary, Kulkarni, Shreeram V, additional, Gupta, Sandeep, additional, and V., Parthasarathy, additional
- Published
- 2022
- Full Text
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433. Applications of Additive Manufacturing Techniques in Aerospace Industry
- Author
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Kumar, S. Anand, primary, Pathania, Akshay, additional, Shrivastava, Abhishek, additional, Rajkumar, V., additional, and Raghupatruni, Prasad, additional
- Published
- 2022
- Full Text
- View/download PDF
434. Author response: Timeline of changes in spike conformational dynamics in emergent SARS-CoV-2 variants reveal progressive stabilization of trimer stalk with altered NTD dynamics
- Author
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Varun Venkatakrishnan, Theresa SC Buckley, Sean M Braet, Kim-Marie A Dam, Pamela J Bjorkman, and Ganesh S Anand
- Published
- 2023
435. Somatic variants and exon-level copy number changes in five hyperplastic-stage oral leukoplakias
- Author
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Anuhya Anne, Lov Kumar, Revanth K. Salavadi, Pradeep S. Anand, Swapna Nuguri, Sukhvinder Bindra, Kanapuram V. R. Reddy, Madhusudhana R. Gummanur, and Kommu N. Mohan
- Subjects
Genetics ,Molecular Biology ,Genetics (clinical) - Abstract
Oral leukoplakia (OL), an oral potentially malignant disorder begins with a hyperplastic/hyperkeratotic stage at which no genome-scale somatic single nucleotide variant profiles have been described so far. We performed exome sequencing of five cases at this stage with no evidence of dysplasia to identify genetic alterations (exon-level copy number alterations, indels, and single nucleotide variants), their association with transcript levels and relationship with oral cancer susceptibility. Pathway enrichment analysis of genes associated with tobacco chewing and age-related mutation signatures, transcripts with variants predicted to be functionally damaging and those with significantly altered levels have all indicated the involvement of focal adhesion, ECM–receptor interactions, regulation of cytoskeleton and DNA repair. Two novel mutations identified in FAT1 tumor suppressor gene were associated with decreased transcript levels. In addition, 16 expressed cancer driver genes contained functionally damaging variants. Many of the affected genes were also reported in dysplastic OL lesions. The presence of variants in cancer driver genes and those shared with oral dysplasias possibly provide a basis for further progression and increased susceptibility to oral cancer.
- Published
- 2023
436. List of contributors
- Author
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M.M. Abdel-Mottaleb, Bader Alqahtani, Sergio T. Amancio-Filho, S. Anand Kumar, Siegfried Arneitz, Ricardo Henrique Buzolin, Pedro dos Santos Effertz, Abou Bakr Elshalakany, Norbert Enzinger, Carlos Alberto Feliciano Belei, Jochen Giedenbacher, Rafael Paiotti M. Guimarães, Franz Haas, Aziz Huskic, C.T. Justus Panicker, M. Kumaran, Benjamin Meier, Lisa Minkowitz, Marcel Müller, Florian Pixner, Prasad Raghupatruni, D. Rajamani, Samrat Rao, Sachin Salunkhe, T. Sathies, V. Senthilkumar, Abhishek Shrivastava, Mateusz Skalon, Christof Sommitsch, and Norbert Wild
- Published
- 2023
437. Computer vision based online monitoring technique: part quality enhancement in the selective laser melting process
- Author
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Brahmansh Kaushik and S. Anand Kumar
- Published
- 2023
438. Geometrical Form Deviation and Defect Analysis of SLM Processed Slender Parts Using Computer Vision Methodology
- Author
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Brahmansh Kaushik, S. Anand Kumar, and V. Rajkumar
- Published
- 2023
439. Bio-inspired advancements in additive manufacturing
- Author
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Ruban Whenish, Selvam Arivazhagan, Rajkumar Velu, and S Anand Kumar
- Published
- 2023
440. Dual wide band patch antenna for WLAN/WiMAX and X-Band operations
- Author
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Rekha G. Nair, P.D. Geo Emmanuel, Allen Jose Benny, S. Anand, Alen Thomas, and B. Smitha
- Subjects
General Medicine - Published
- 2023
441. Postprocessing challenges in metal AM: Strategies for achieving homogeneous microstructure in Ni-based superalloys
- Author
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Abhishek Shrivastava, S. Anand Kumar, and Samrat Rao
- Published
- 2023
442. SARS-CoV-2 spike protein as a bacterial lipopolysaccharide delivery system in an overzealous inflammatory cascade
- Author
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Firdaus Samsudin, Palur Raghuvamsi, Ganna Petruk, Manoj Puthia, Jitka Petrlova, Paul MacAry, Ganesh S Anand, Peter J Bond, and Artur Schmidtchen
- Subjects
SARS-CoV-2 ,lipopolysaccharide ,Genetics ,hyperinflammation ,COVID-19 ,Cell Biology ,General Medicine ,TLR4 ,spike protein ,Molecular Biology - Abstract
Accumulating evidence indicates a potential role for bacterial lipopolysaccharide (LPS) in the overactivation of the immune response during SARS-CoV-2 infection. LPS is recognized by Toll-like receptor 4, mediating proinflammatory effects. We previously reported that LPS directly interacts with SARS-CoV-2 spike (S) protein and enhances proinflammatory activities. Using native gel electrophoresis and hydrogen–deuterium exchange mass spectrometry, we showed that LPS binds to multiple hydrophobic pockets spanning both the S1 and S2 subunits of the S protein. Molecular simulations validated by a microscale thermophoresis binding assay revealed that LPS binds to the S2 pocket with a lower affinity compared to S1, suggesting a role as an intermediate in LPS transfer. Congruently, nuclear factor-kappa B (NF-κB) activation in monocytic THP-1 cells is strongly boosted by S2. Using NF-κB reporter mice followed by bioimaging, a boosting effect was observed for both S1 and S2, with the former potentially facilitated by proteolysis. The Omicron S variant binds to LPS, but with reduced affinity and LPS boosting in vitro and in vivo. Taken together, the data provide a molecular mechanism by which S protein augments LPS-mediated hyperinflammation.
- Published
- 2023
443. List of contributors
- Author
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Nesma T. Aboulkhair, Puneeta Ajmera, Esther T. Akinlabi, S.A. Akinlabi, Hend Alqaydi, Nujood Alshehhi, S. Anand Kumar, Dheeraj Kumar Angajala, Selvam Arivazhagan, Jayesh Bellare, Amit Bhardwaj, Anurag Bhatnagar, Sudip Dasgupta, Arup Dey, Amal M.K. Esawi, Victor Gambhir, Natalia B. Ghisi C, Carmen M. González-Henríquez, Deepak Gupta, Abid Haleem, Sunir Hassan, Vineet Jain, Mohd Javaid, T-C. Jen, Anita Jena, K. Kalaichelvan, Sheetal Kalra, Brahmansh Kaushik, Ajay Kumar, Arvind Kumar, Cheruvu Siva Kumar, Lokesh Kumar, Parveen Kumar, M. Kumaran, Rasheedat M. Mahamood, Mayurkumar A. Makhesana, Ashish Kumar Mishra, Santosh Kr. Mishra, Ravi Kant Mittal, Bidyut Pal, Kaushik M. Patel, Dan A. Pérez-Monje, Mona Prabhakar, Kishore Pradeep, Rija Nirina Raoelison, Juan Rodríguez-Hernández, Fernando E. Rodríguez-Umanzor, Ankit Sahai, Bijaya Bikram Samal, Mauricio A. Sarabia-Vallejos, T. Sathies, Sonam Sehrawat, V. Senthilkumar, Rahul Swarup Sharma, Mohd Shoeb, Hari Singh, Yogendra Pratap Singh, P.R. Sreeraj, J. Srinivas, S. Stalin, U. Sudhakar, Tadele Belay Tuli, Shailendra Kumar Varshney, Rajkumar Velu, Ruban Whenish, Anshul Yadav, Kuldeep Yadav, Sheetal Yadav, and Nita Yodo
- Published
- 2023
444. High-resolution measurements from the airborne Atmospheric Nitrogen Dioxide Imager (ANDI)
- Author
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J. P. Lawrence, J. S. Anand, J. D. Vande Hey, J. White, R. R. Leigh, P. S. Monks, and R. J. Leigh
- Subjects
Environmental engineering ,TA170-171 ,Earthwork. Foundations ,TA715-787 - Abstract
Nitrogen dioxide is both a primary pollutant with direct health effects and a key precursor of the secondary pollutant ozone. This paper reports on the development, characterisation and test flight of the Atmospheric Nitrogen Dioxide Imager (ANDI) remote sensing system. The ANDI system includes an imaging UV/Vis grating spectrometer able to capture scattered sunlight spectra for the determination of tropospheric nitrogen dioxide (NO2) concentrations by way of DOAS slant column density and vertical column density measurements. Results are shown for an ANDI test flight over Leicester City in the UK on a cloud-free winter day in February 2013. Retrieved NO2 columns gridded to a surface resolution of 80 m × 20 m revealed hotspots in a series of locations around Leicester City, including road junctions, the train station, major car parks, areas of heavy industry, a nearby airport (East Midlands) and a power station (Ratcliffe-on-Soar). In the city centre the dominant source of NO2 emissions was identified as road traffic, contributing to a background concentration as well as producing localised hotspots. Quantitative analysis revealed a significant urban increment over the city centre which increased throughout the flight.
- Published
- 2015
- Full Text
- View/download PDF
445. Analysis of a Multilevel Voltage-Based Coordinating Controller for Solar-Wind Energy Generator: A Simulation, Development and Validation Approach
- Author
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T. Lachumanan, R. Singh, M. I. Shapiai, and T. J. S. Anand
- Subjects
Matlab/Simulink ,coordinating controller ,solar-wind ,T1-995 ,Information technology ,TA1-2040 ,renewable energy sources ,Engineering (General). Civil engineering (General) ,T58.5-58.64 ,voltage-based ,Technology (General) - Abstract
This paper presents the development and the performance analysis of the developed model of a voltage-based coordinating controller. This model is developed to perform activities such as sensing, measuring, switching, coordinating, and effectively managing the output voltages produced by the solar-wind renewable energy sources in order to supply the connected load or/and charge the battery storage system. The developed model has different tasks to perform when solar-wind energy sources both produce output voltages simultaneously, also contributing to solving the requirements of different synchronization algorithms for a multi-agent renewable energy system. The sensed and measured output voltages of the solar-wind energy sources are used as directive information to allow the developed model’s controller to supply the available power to the connected load or/and charge the battery storage system. Also, the produced information at the model’s controller input is used to individually control the other sub-system, which directly assists in achieving the aim of simultaneous operation when both solar and wind energy sources produce output voltages. The model is developed and simulated in Matlab/Simulink. The simulation results are used to validate the developed methodology and the aims of the developed model.
- Published
- 2021
446. Reduction in Acute Limb Ischemia With Rivaroxaban Versus Placebo in Peripheral Artery Disease After Lower Extremity Revascularization: Insights From VOYAGER PAD
- Author
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Sonia S. Anand, Judith Hsia, Marianne Brodmann, Marc P. Bonaca, Henrik Sillesen, Nicholas J. Leeper, E. Sebastian Debus, Eva Muehlhofer, Connie N. Hess, Joshua A. Beckman, Peter Habertheuer, Rafael Diaz, Rupert Bauersachs, Michael Szarek, Scott D. Berkowitz, Manesh R. Patel, Richard J. Powell, Lloyd Haskell, Mark R. Nehler, and Warren H. Capell
- Subjects
Male ,medicine.medical_specialty ,medicine.medical_treatment ,Placebo ,Revascularization ,Rivaroxaban ,Ischemia ,peripheral arterial disease ,Physiology (medical) ,Internal medicine ,medicine ,Humans ,Cumulative incidence ,Myocardial infarction ,rivaroxaban ,thrombosis ,Aged ,Aspirin ,business.industry ,Hazard ratio ,Middle Aged ,medicine.disease ,Clopidogrel ,respiratory tract diseases ,Lower Extremity ,Amputation ,Acute Disease ,lower extremity ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business ,Numbers Needed To Treat ,medicine.drug - Abstract
Background: Patients with peripheral artery disease (PAD) are at heightened risk of acute limb ischemia (ALI), a thrombotic event associated with amputation, disability, and mortality. Previous lower extremity revascularization (LER) is associated with increased ALI risk in chronic PAD. However, the pattern of risk, clinical correlates, and outcomes after ALI early after LER are not well-studied, and effective therapies to reduce ALI post-LER are lacking. Methods: The VOYAGER PAD trial (Vascular Outcomes Study of ASA [Acetylsalicylic Acid] Along With Rivaroxaban in Endovascular or Surgical Limb Revascularization for PAD; rNCT02504216) randomized patients with PAD undergoing LER to rivaroxaban 2.5 mg twice daily or placebo on a background of low-dose aspirin. The primary outcome was a composite of ALI, major amputation of vascular cause, myocardial infarction, ischemic stroke, or cardiovascular death. ALI was prospectively ascertained and adjudicated by a blinded committee. The cumulative incidence of ALI was calculated using Kaplan-Meier estimates, and Cox proportional hazards models were used to generate hazard ratios and associated CIs. Analyses were performed as intention-to-treat. Results: Among 6564 patients followed for a median of 2.3 years, 382 (5.8%) had a total of 508 ALI events. In placebo patients, the 3-year cumulative incidence of ALI was 7.8%. After multivariable modeling, previous LER, baseline ankle-brachial index P =0.0001), with benefit starting early (HR, 0.45 [95% CI, 0.24–0.85]; P =0.0068 at 30 days). Benefit was present for severe ALI (associated with death, amputation, or prolonged hospitalization and intensive care unit stay, HR, 0.58 [95% CI, 0.40–0.83]; P =0.003) and regardless of LER type (surgical versus endovascular revascularization, P interaction=0.42) or clopidogrel use ( P interaction=0.59). Conclusions: After LER for symptomatic PAD, ALI is frequent, particularly early after LER, and is associated with poor prognosis. Low-dose rivaroxaban plus aspirin reduces ALI after LER, including ALI events associated with the most severe outcomes. The benefit of rivaroxaban for ALI appears early, continues over time, and is consistent regardless of revascularization approach or clopidogrel use.
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- 2021
447. Equity and Game-Theory Strategies to Promote Gender Diversity and Inclusion in an Academic Health Science Centre
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Mark Crowther, William Harper, Sonia S. Anand, Ali Ariaeinejad, and Yijinmide Buren
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Medical education ,Gender diversity ,media_common.quotation_subject ,Equity (finance) ,humanities ,Promotion (rank) ,RC666-701 ,Diseases of the circulatory (Cardiovascular) system ,Original Article ,Salary ,Cardiology and Cardiovascular Medicine ,Psychology ,Productivity ,Inclusion (education) ,Game theory ,Diversity (business) ,media_common - Abstract
Background: Achieving diversity, inclusion, and gender equity remains an elusive challenge for many institutions worldwide and is understudied in Canadian academic health science centres. Methods: McMaster University’s Department of Medicine undertook surveys and analyses to determine whether there was inequity in leadership positions and salaries, or unprofessional behaviour within the department. Measures of academic productivity in relation to gender for both educators and researchers were analyzed. The department began shifting policies to foster greater gender diversity and inclusion. A revision of the leadership selection process, incorporating tenets of equity and a new game theory–based strategy called Diversitive Agreement Versus Nash Equilibrium (DAvNE) was evaluated. Results: The department’s survey revealed underrepresentation of women and people of colour in leadership positions, with perceived barriers to their promotion. Both women and people of colour reported experiencing unprofessional behaviour directed toward them. A gender gap in base salary was observed, with female full professors being paid less. No difference in academic productivity was seen between male and female educators or researchers. The leadership competitions conducted under new selection processes emphasizing diversity resulted in 66% of participating women securing a leadership position, in comparison to 25% of participating men. People of colour made up 27% of members participating in these leadership competitions, but none was successful in obtaining a position. Conclusions: Diversity and inclusion disparities in the Department of Medicine at McMaster University indicate a need for further efforts and innovation to bring about greater gender and racial equity. Résumé: Contexte: La mise en place des conditions nécessaires à la diversité, à l’inclusion et à l’équité des genres demeure un défi difficile à relever pour de nombreux établissements dans le monde entier. C’est une démarche peu étudiée dans les centres universitaires canadiens des sciences de la santé. Méthodologie: Le département de médecine de l’Université McMaster a mené des sondages et des analyses en vue de déterminer s’il existait en son sein même des iniquités en matière d’attribution des postes de direction et de fixation des salaires, ou des comportements non professionnels. Des mesures de la productivité universitaire des éducateurs et des chercheurs ont été analysées en fonction des genres. Le département a entrepris une réforme de ses politiques afin de favoriser une plus grande diversité et inclusion des genres. Une révision du processus de sélection des candidats aux postes de direction, intégrant les principes d’équité et une nouvelle stratégie fondée sur la théorie des jeux appelée Diversitive Agreement Versus Nash Equilibrium (DAvNE [accord de diversité vs équilibre de Nash]), a été évaluée. Résultats: Le sondage du département a révélé qu’il existait une sous-représentation des femmes et des personnes de couleur parmi les titulaires des postes de direction, ainsi que des obstacles perçus à leur promotion. Tant les femmes que les personnes de couleur ont fait état de comportements non professionnels à leur endroit. Un écart entre les genres a été observé au chapitre de la rémunération de base, les professeurs titulaires de sexe féminin étant moins rémunérées. Aucune différence n’a été observée sur le plan de la productivité universitaire entre les femmes et les hommes au sein de l’effectif des éducateurs et des chercheurs. Les concours pour les postes de direction ont été organisés en fonction de nouveaux processus de sélection mettant l’accent sur la diversité. Au final, 66 % des candidats qui ont vu leur candidature retenue étaient des femmes et 25 %, des hommes. Dans le cadre de ces concours, 27 % des candidats étaient des personnes de couleur, mais aucun n’a réussi à obtenir un poste. Conclusions: Les disparités notées en matière de diversité et d’inclusion au sein du département de médecine de l’Université McMaster montrent que l’atteinte d’une plus grande équité des genres et des races passe par des efforts et une innovation soutenus.
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- 2021
448. Enhancing MRI Brain Images Using Contourlet Transform and Adaptive Histogram Equalization
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J. Murugachandravel and S. Anand
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ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION ,Health Informatics ,Radiology, Nuclear Medicine and imaging - Abstract
Human brain can be viewed using MRI images. These images will be useful for physicians, only if their quality is good. We propose a new method called, Contourlet Based Two Stage Adaptive Histogram Equalization (CBTSA), that uses Nonsubsampled Contourlet Transform (NSCT) for smoothing images and adaptive histogram equalization (AHE), under two occasions, called stages, for enhancement of the low contrast MRI images. The given MRI image is fragmented into equal sized sub-images and NSCT is applied to each of the sub-images. AHE is imposed on each resultant sub-image. All processed images are merged and AHE is applied again to the merged image. The clarity of the output image obtained by our method has outperformed the output image produced by traditional methods. The quality was measured and compared using criteria like, Entropy, Absolute Mean Brightness Error (AMBE) and Peak Signal to Noise Ratio (PSNR).
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- 2021
449. Boundary-type sets of strong product of directed graphs
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Mary Shalet Thottungal Joseph, Bijo S. Anand, Manoj Changat, and Prasanth G. Narasimha-Shenoi
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Strongly connected component ,Algebra and Number Theory ,Boundary (topology) ,Digraph ,Directed graph ,Type (model theory) ,Theoretical Computer Science ,Combinatorics ,Product (mathematics) ,Path (graph theory) ,Metric (mathematics) ,Discrete Mathematics and Combinatorics ,Geometry and Topology ,Mathematics - Abstract
Let D = ( V , E ) be a strongly connected digraph and let u and v be two vertices in D . The maximum distance md( u , v ) is defined as md( u , v ) = max{ d ( u , v ), d ( v , u )} , where d ( u , v ) denotes the length of a shortest directed u - v path in D . This is a metric. The boundary, contour, eccentricity and periphery sets of a strongly connected digraph D with respect to this metric have been defined. The boundary-type sets of the strong product of two digraphs is investigated in this article.
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- 2021
450. Effect of different polyvinylpyrrolidone and 3-mercaptopropionic acid concentrations on structural, morphological, and optical properties of cadmium sulfide quantum dots
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A. Manikandan, S. Muniyappan, P. Murugakoothan, P. Ramasamy, S. Anand, Muthu Senthil Pandian, and P. Karuppasamy
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Photoluminescence ,Materials science ,Polyvinylpyrrolidone ,Condensed Matter Physics ,Atomic and Molecular Physics, and Optics ,Cadmium sulfide ,Electronic, Optical and Magnetic Materials ,chemistry.chemical_compound ,chemistry ,Dynamic light scattering ,Quantum dot ,medicine ,Electrical and Electronic Engineering ,Fourier transform infrared spectroscopy ,Spectroscopy ,Powder diffraction ,Nuclear chemistry ,medicine.drug - Abstract
The ultimate aim of this manuscript is to understand and analyze the influence of polyvinylpyrrolidone (PVP) and 3-mercaptopropionic acid (3-MPA) concentrations on the properties of cadmium sulfide (CdS) quantum dots. In this scenario, PVP- and 3-MPA-capped CdS quantum dots (QDs) were prepared through chemical precipitation method. The synthesized CdS quantum dots were characterized by powder X-ray diffraction (PXRD) analysis, Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy-dispersive X-ray (EDX) analysis, ultraviolet–visible (UV–Vis) reflectance spectroscopy, photoluminescence (PL) analysis, the Commission International de I’Eclairage (CIE) 1931 chromaticity analysis, and dynamic light scattering (DLS) study.
- Published
- 2021
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