2,104 results on '"Rodriguez, Martin"'
Search Results
402. Contrast Estimation in Vibroacoustic Signals for Diagnosing Early Faults of Short-Circuited Turns in Transformers under Different Load Conditions
- Author
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Huerta-Rosales, Jose R., primary, Granados-Lieberman, David, additional, Amezquita-Sanchez, Juan P., additional, Garcia-Perez, Arturo, additional, Bueno-Lopez, Maximiliano, additional, and Valtierra-Rodriguez, Martin, additional
- Published
- 2022
- Full Text
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403. Detection of Multiple Faults in a Low-Power Wind Turbine by using Convolutional Neural Networks
- Author
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Rangel-Rodriguez, Angel H., primary, Huerta-Rosales, Jose R., additional, Amezquita-Sanchez, Juan P., additional, Granados-Lieberman, David, additional, Bueno-Lopez, Maximiliano, additional, and Valtierra-Rodriguez, Martin, additional
- Published
- 2022
- Full Text
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404. Incipient Damage Detection in a Truss-Type Bridge using vibration responses and MUSIC Technique
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Hernandez-Maqueda, Cristian J., primary, Amezquita-Sanchez, Juan P., additional, Valtierra-Rodriguez, Martin, additional, Perez-Ramirez, Carlos A., additional, Dominguez-Gonzalez, Aurelio, additional, Toledano-Ayala, Manuel, additional, and Morales-Hernandez, Luis A., additional
- Published
- 2022
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405. Corneal topography using dynamic point shifting method in quadrangular OLED´s prism
- Author
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Rodriguez Rodriguez, Martin I., primary, Valderrama Juárez, Carlos Enrique, additional, Damián Zamacona, Juan Ricardo, additional, and Diaz Uribe, Rufino, additional
- Published
- 2022
- Full Text
- View/download PDF
406. Control of prenatal exposures to mercury in Europe: harmonized communication of fish-consumption advice to pregnant women combined with human biomonitoring
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Katsonouri, Andromachi, primary, Gabriel, Catherine, additional, Esteban López, Marta, additional, Halldórsson, Þórhallur Ingi, additional, Namorado, Sónia, additional, Snoj Tratnik, Janja, additional, Giannadaki, Despina, additional, Karakitsios, Spyros, additional, Anastasi, Elena, additional, Rodriguez Martin, Laura, additional, Horvat, Milena, additional, Karakoltzidis, Achilleas, additional, Domínguez Morueco, Noelia, additional, Thoma, Chrysanthi, additional, Eiríksdóttir, Ása Valgerður, additional, Assunção, Ricardo Manuel Abreu de, additional, and Sarigiannis, Dimosthenis, additional
- Published
- 2022
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407. Concurrent Assessment of Phthalates/HEXAMOLL® DINCH Exposure and Wechsler Intelligence Scale for Children Performance in Three European Cohorts of the HBM4EU Aligned Studies
- Author
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Rosolen, Valentina, primary, Giordani, Elisa, additional, Mariuz, Marika, additional, Parpinel, Maria, additional, Ronfani, Luca, additional, Vecchi Brumatti, Liza, additional, Bin, Maura, additional, Calamandrei, Gemma, additional, Mustieles, Vicente, additional, Gilles, Liese, additional, Govarts, Eva, additional, Baken, Kirsten, additional, Rodriguez Martin, Laura, additional, Schoeters, Greet, additional, Sepai, Ovnair, additional, Sovcikova, Eva, additional, Fabelova, Lucia, additional, Šidlovská, Miroslava, additional, Kolena, Branislav, additional, Kold Jensen, Tina, additional, Frederiksen, Hanne, additional, Kolossa-Gehring, Marike, additional, Lange, Rosa, additional, Apel, Petra, additional, Castano, Argelia, additional, Esteban López, Marta, additional, Jacobs, Griet, additional, Voorspoels, Stefan, additional, Jurdáková, Helena, additional, Górová, Renáta, additional, and Barbone, Fabio, additional
- Published
- 2022
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408. Early Mobilization Program in a Pediatric Intensive Care Unit
- Author
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Garcia Delgado, E, primary, Sanchez Ezquerra, E, additional, Tores Garcia, E, additional, Moran Arribas, S, additional, Herrera Monge, P, additional, Daza Diaz, A, additional, Protero Diaz, M, additional, Rodriguez Martin, A, additional, Garcia De Las Peñas, S, additional, Ordoñez Saez, O, additional, Ramos Casado, V, additional, Hernandez Gil, M, additional, Lopez Sanchez, E, additional, and Prieto Arroyo, G, additional
- Published
- 2022
- Full Text
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409. Fourier-Based Adaptive Signal Decomposition Method Applied to Fault Detection in Induction Motors
- Author
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De Santiago-Perez, J. Jesus, primary, Valtierra-Rodriguez, Martin, additional, Amezquita-Sanchez, Juan Pablo, additional, Perez-Soto, Gerardo Israel, additional, Trejo-Hernandez, Miguel, additional, and Rivera-Guillen, Jesus Rooney, additional
- Published
- 2022
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410. Cooling analysis of welded materials for crack detection using infrared thermography
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Rodríguez-Martin, M., Lagüela, S., González-Aguilera, D., and Arias, P.
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- 2014
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411. Association Between Bullous Pemphigoid and Neurologic Diseases: A Case-Control Study
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Casas-de-la-Asunción, E., Ruano-Ruiz, J., Rodríguez-Martín, A.M., Vélez García-Nieto, A., and Moreno-Giménez, J.C.
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- 2014
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412. Asociación de penfigoide y enfermedad neurológica: estudio de casos y controles
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Casas-de-la-Asunción, E., Ruano-Ruiz, J., Rodríguez-Martín, A.M., Vélez García-Nieto, A., and Moreno-Giménez, J.C.
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- 2014
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413. A branch-and-cut algorithm for the hub location and routing problem
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Rodríguez-Martín, Inmaculada, Salazar-González, Juan-José, and Yaman, Hande
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- 2014
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414. Monitorización ambulatoria de la presión arterial y actividad física en pacientes hipertensos
- Author
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García-Ortiz, L., de Cabo-Laso, A., Rodriguez-Martín, C., Recio-Rodríguez, J.I., Garcia Garcia, A., Rodriguez-Sanchez, E., Agudo-Conde, C., and Gomez-Marcos, M.A.
- Published
- 2014
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415. Comparison of the duration and power spectral changes of monopolar and bipolar M waves caused by alterations in muscle fibre conduction velocity
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Rodriguez-Falces, Javier, Navallas, Javier, Malanda, Armando, and Rodriguez-Martin, Olivia
- Published
- 2014
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416. Evaluation of an Advanced Physical Diagnosis Course Using Consumer Preferences Methods: The Nominal Group Technique
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Coker, Joshua, Castiglioni, Analia, Stanford Massie, F., Russell, Stephen W., Shaneyfelt, Terrance, Willett, Lisa L., Estrada, Carlos A., Kraemer, Ryan R., Morris, Jason L., and Rodriguez, Martin
- Published
- 2014
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417. Percepción del entorno para la práctica de actividad física en escolares de la provincia de Cuenca, España
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Gutiérrez-Zornoza, Myriam, Rodríguez-Martín, Beatriz, Martínez-Andrés, María, García-López, Úrsula, and Sánchez-López, Mairena
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- 2014
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418. Nefritis intersticial cariomegálica
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Martelli Guerrero, Xhamy, Monfa Guix, Elena, Alzoghby Abi Chaker, Jacques, Álvarez Cañas, Concepción, Rodríguez Martin, Laura, Martínez Rosero, Catherine, Romero Zaldumbide, Erika, Stifan Kasabji, George, Sastre López, Aránzazu, Lucas Álvarez, Cristina, de León Gómez, Benjamín, and Prieto Velasco, Mario
- Published
- 2024
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419. History of the discovery and development of Biomodulina T (InmunyVital®), a useful immunomodulator with a broad range of clinical applications
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Roman R. Rodriguez Martin, Olivia Gonzalez Gonzalez, Carolina Rodriguez Gonzalez, and Rene R. Rodriguez Gonzalez
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Pharmacology ,Immunology ,Immunology and Allergy - Published
- 2023
420. A System for Dynamic Adaptation of Web Interfaces Based on User Interaction Requirements
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Gonzalez-Pisano, Javier, Rodriguez-Fernandez, Maria, Gonzalez-Rodriguez, Martin, Bobes-Bascaran, Jose Ramon, Garcia-Marsa, Jaime, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Miesenberger, Klaus, editor, Klaus, Joachim, editor, Zagler, Wolfgang, editor, and Karshmer, Arthur, editor
- Published
- 2008
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421. P14 Reference Values of the West Spanish Population of the Hemodynamic Indices Evaluated with a New Wrist Worn Device
- Author
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Gomez-Sanchez, Marta, Gomez-Sanchez, Leticia, Alonso-Domínguez, Rosario, Gonzalez-Sanchez, Jesus, Agudo-Conde, Cristina, Sánchez-Aguadero, Natalia, Rodriguez-Martin, Carmela, and Garcia-Ortiz, Luis
- Published
- 2018
- Full Text
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422. Remote Navigability Testing Using Data Gathering Agents
- Author
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Gonzalez-Rodriguez, Martin, Diez-Diaz, Fidel, Vidau, Agueda, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, and Stephanidis, Constantine, editor
- Published
- 2007
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423. An Accesible and Collaborative Tourist Guide Based on Augmented Reality and Mobile Devices
- Author
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Díez-Díaz, Fidel, González-Rodríguez, Martín, Vidau, Agueda, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, and Stephanidis, Constantine, editor
- Published
- 2007
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424. Protophormia terraenovae. A new allergenic species in amateur fishermen of Caceres, Spain
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Porcel Carreño, Sergio, de la Losa, Fernando Pineda, Frontera Carrión, Eva, Rodríguez Martín, Elena, Ramos Cantariño, Alfonso, Sánchez González, Ana, Rodríguez Trabado, Ana, Jiménez Timón, Soledad, Alvarado Arenas, Manuela, Medina Velasco, Víctor, Rodríguez Martín, María, and Hernández Arbeiza, Javier
- Published
- 2009
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425. Transplanting FVIII/ET3-secreting cells in fetal sheep increases FVIII levels long-term without inducing immunity or toxicity.
- Author
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Rodriguez, Martin, Trevisan, Brady, Ramamurthy, Ritu M., George, Sunil K., Diaz, Jonathan, Alexander, Jordan, Meares, Diane, Schwahn, Denise J., Quilici, David R., Figueroa, Jorge, Gautreaux, Michael, Farland, Andrew, Atala, Anthony, Doering, Christopher B., Spencer, H. Trent, Porada, Christopher D., and Almeida-Porada, Graça
- Subjects
FETUS ,HEMOPHILIA treatment ,HEMOPHILIACS ,HEMOPHILIA ,SHEEP ,IMMUNITY ,SHEEP breeding ,FRAGILE X syndrome - Abstract
Hemophilia A is the most common X-linked bleeding disorder affecting more than half-a-million individuals worldwide. Persons with severe hemophilia A have coagulation FVIII levels <1% and experience spontaneous debilitating and life-threatening bleeds. Advances in hemophilia A therapeutics have significantly improved health outcomes, but development of FVIII inhibitory antibodies and breakthrough bleeds during therapy significantly increase patient morbidity and mortality. Here we use sheep fetuses at the human equivalent of 16–18 gestational weeks, and we show that prenatal transplantation of human placental cells (10
7 –108 /kg) bioengineered to produce an optimized FVIII protein, results in considerable elevation in plasma FVIII levels that persists for >3 years post-treatment. Cells engraft in major organs, and none of the recipients mount immune responses to either the cells or the FVIII they produce. Thus, these studies attest to the feasibility, immunologic advantage, and safety of treating hemophilia A prior to birth. The authors show in a preclinical large animal model that in utero delivery of FVIII-secreting human placental cells is feasible, safe, and yields elevated plasma FVIII activity for at least three years without triggering immunity, affirming prenatal treatment of hemophilia A. [ABSTRACT FROM AUTHOR]- Published
- 2023
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426. A Novel Wavelet Transform-Homogeneity Model for Sudden Cardiac Death Prediction Using ECG Signals
- Author
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Amezquita-Sanchez, Juan P., Valtierra-Rodriguez, Martin, Adeli, Hojjat, and Perez-Ramirez, Carlos A.
- Published
- 2018
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427. An Iterated Local Search Heuristic for a Capacitated Hub Location Problem
- Author
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Rodríguez-Martín, Inmaculada, Salazar-González, Juan-José, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Almeida, Francisco, editor, Blesa Aguilera, María J., editor, Blum, Christian, editor, Moreno Vega, José Marcos, editor, Pérez Pérez, Melquíades, editor, Roli, Andrea, editor, and Sampels, Michael, editor
- Published
- 2006
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428. Identification and Differential Diagnosis of Traumatic Lesions of the Skeleton
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Rodríguez-Martín, Conrado, Schmitt, Aurore, editor, Cunha, Eugénia, editor, and Pinheiro, João, editor
- Published
- 2006
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429. SVM-based posture identification with a single waist-located triaxial accelerometer
- Author
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Rodriguez-Martin, Daniel, Samà, Albert, Perez-Lopez, Carlos, Català, Andreu, Cabestany, Joan, and Rodriguez-Molinero, Alejandro
- Published
- 2013
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430. Exposure to Morphine and Cocaine Modify the Transcriptomic Landscape in Zebrafish Embryos
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Andrés Angel Calderon-Garcia, Maria Perez-Fernandez, Daniel Curto-Aguilera, Ivan Rodriguez-Martin, Mercedes Sánchez-Barba, and Veronica Gonzalez-Nunez
- Subjects
General Neuroscience - Abstract
Morphine and other opioid analgesics are the drugs of election to treat moderate-to-severe pain, and they elicit their actions by binding to the opioid receptors. Cocaine is a potent inhibitor of dopamine, serotonin, and noradrenaline reuptake, as it blocks DAT, the dopamine transporter, causing an increase in the local concentration of these neurotransmitters in the synaptic cleft. The molecular effects of these drugs have been studied in specific brain areas or nuclei, but the systemic effects in the whole organism have not been comprehensively analyzed. This study aims to analyze the transcriptomic changes elicited by morphine (10 uM) and cocaine (15 uM) in zebrafish embryos. An RNAseq assay was performed with tissues extracts from zebrafish embryos treated from 5 hpf (hours post fertilization) to 72 hpf, and the most representative deregulated genes were experimentally validated by qPCR. We have found changes in the expression of genes related to lipid metabolism, chemokine receptor ligands, visual system, hemoglobins, and metabolic detoxification pathways. Besides, morphine and cocaine modified the global DNA methylation pattern in zebrafish embryos, which would explain the changes in gene expression elicited by these two drugs of abuse.
- Published
- 2022
431. Measuring the role of age in user performance during interaction with computers
- Author
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Pariente-Martinez, Beatriz, Gonzalez-Rodriguez, Martin, Fernandez-Lanvin, Daniel, and De Andres-Suarez, Javier
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- 2016
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432. Two-Dimensional Coupled Distributed Hydrologic–Hydraulic Model Simulation on Watershed
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Cea, Miguel and Rodriguez, Martin
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- 2016
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433. Disrupted T Cell Receptor Signaling Pathways in Systemic Autoimmunity
- Author
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Blasini, Ana M., Rodríguez, Martín A., and Zouali, Moncef, editor
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- 2005
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434. Antipsychotics and neutropoenia: An update
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Rodriguez Luis Menendez, Blas Santiago Fernandez, Hernandez Sanchez Maria Del Carmen, Rodriguez Martin Menendez, Mendez Sanchez Jose Angel, and Perez Antonio Iglesias
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business.industry ,Medicine ,General Medicine ,business - Published
- 2021
435. Aberrant integration of Hepatitis B virus DNA promotes major restructuring of human hepatocellular carcinoma genome architecture
- Author
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Hidewaki Nakagawa, Hiroshi Aikata, Mónica Martínez-Fernández, Atsushi Ono, Marta Tojo, Peter J. Campbell, Adrian Baez-Ortega, Kerstin Haase, Jonas Demeulemeester, Adam Butler, Xavier Forns, Rosanna Abal, Keiran Raine, Javier Temes, Urtzi Garaigorta, Daniel García-Souto, Carmen Rivas, Aitor Rodriguez-Casanova, Eva G. Alvarez, Sonia Zumalave, Jorge Zamora, Hiroki Yamaue, Clemency Jolly, Yang Li, Peter Van Loo, Jose M. C. Tubio, Kazuaki Chayama, Iago Otero, Sofía Pérez-del-Pulgar, Masaki Ueno, Miguel Blanco, Shinya Hayami, Sandra Rodriguez-Perales, Kazuhiro Maejima, Jorge Rodríguez-Castro, Angel Diaz-Lagares, Raúl Torres-Ruiz, Ana Pequeño-Valtierra, Juan Ruiz-Bañobre, Ana Oitaben, Bernardo Rodriguez-Martin, Paula Otero, Alicia L. Bruzos, Álvarez, Eva G [0000-0002-3522-5088], Demeulemeester, Jonas [0000-0002-2660-2478], Otero, Paula [0000-0001-5614-1468], García-Souto, Daniel [0000-0002-0997-8799], Temes, Javier [0000-0003-3370-4728], Rodriguez-Martin, Bernardo [0000-0003-4693-3140], Oitaben, Ana [0000-0002-4877-6145], Bruzos, Alicia L [0000-0003-4362-545X], Haase, Kerstin [0000-0002-0944-5618], Zumalave, Sonia [0000-0002-2108-1861], Rodríguez-Castro, Jorge [0000-0003-2912-9601], Rodriguez-Casanova, Aitor [0000-0002-9828-3613], Raine, Keiran M [0000-0002-5634-1539], Otero, Iago [0000-0002-7924-693X], Blanco, Miguel G [0000-0002-2883-7326], Ruiz-Bañobre, Juan [0000-0003-0755-4295], Pérez-Del-Pulgar, Sofía [0000-0002-9890-300X], Torres-Ruiz, Raúl [0000-0001-9606-0398], Rodriguez-Perales, Sandra [0000-0001-7221-3636], Garaigorta, Urtzi [0000-0002-0683-5725], Campbell, Peter J [0000-0002-3921-0510], Van Loo, Peter [0000-0003-0292-1949], Tubio, Jose MC [0000-0003-3540-2459], and Apollo - University of Cambridge Repository
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LIVER ,Hepatocellular carcinoma ,General Physics and Astronomy ,medicine.disease_cause ,Genome ,631/67/1858 ,Ecology,Evolution & Ethology ,Cancer genomics ,Tumour virus infections ,631/208/69 ,Human Biology & Physiology ,Multidisciplinary ,Liver Neoplasms ,ASSOCIATION ,READ ALIGNMENT ,TRANSLOCATION ,Multidisciplinary Sciences ,Gene Expression Regulation, Neoplastic ,Science & Technology - Other Topics ,Liver cancer ,Genetics & Genomics ,Hepatitis B virus ,Carcinoma, Hepatocellular ,Science ,Virus Integration ,631/67/1504/1610/4029 ,45/23 ,Biology ,General Biochemistry, Genetics and Molecular Biology ,Virus ,Article ,14/32 ,CHROMOSOMES ,medicine ,Humans ,Gene ,Computational & Systems Biology ,Science & Technology ,Whole Genome Sequencing ,MUTATIONS ,Genome, Human ,Cancer ,General Chemistry ,Tumour Biology ,medicine.disease ,digestive system diseases ,DNA, Viral ,Cancer research ,Carcinogenesis - Abstract
Most cancers are characterized by the somatic acquisition of genomic rearrangements during tumour evolution that eventually drive the oncogenesis. Here, using multiplatform sequencing technologies, we identify and characterize a remarkable mutational mechanism in human hepatocellular carcinoma caused by Hepatitis B virus, by which DNA molecules from the virus are inserted into the tumour genome causing dramatic changes in its configuration, including non-homologous chromosomal fusions, dicentric chromosomes and megabase-size telomeric deletions. This aberrant mutational mechanism, present in at least 8% of all HCC tumours, can provide the driver rearrangements that a cancer clone requires to survive and grow, including loss of relevant tumour suppressor genes. Most of these events are clonal and occur early during liver cancer evolution. Real-time timing estimation reveals some HBV-mediated rearrangements occur as early as two decades before cancer diagnosis. Overall, these data underscore the importance of characterising liver cancer genomes for patterns of HBV integration., Hepatitis B virus (HBV) infection and DNA integration is a frequent cause of hepatocellular carcinoma (HCC), but the consequences of this process are not fully understood. Here the authors use whole-genome and long-read sequencing data from HCC patient samples to study the timing and alterations induced by HBV insertions.
- Published
- 2021
436. Structural Variation in Cancer: Role, Prevalence, and Mechanisms
- Author
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Cosenza, Marco Raffaele, primary, Rodriguez-Martin, Bernardo, additional, and Korbel, Jan O., additional
- Published
- 2022
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437. Efficacy, safety and prognostic factors in patients with refractory metastatic colorectal cancer treated with trifluridine/tipiracil plus bevacizumab in a real-world setting
- Author
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Martínez-Lago, Nieves, primary, Chucla, Teresa Calleja, additional, De Castro, Beatriz Alonso, additional, Ponte, Rafael Varela, additional, Rendo, Cristina Reboredo, additional, Rodriguez, Martin Igor Gomez-Randulfe, additional, Diaz, Sofia Silva, additional, Suarez, Begoña Graña, additional, de la Cámara Gomez, Juan, additional, Fernández, Fernando Busto, additional, Salvador, María Mateos, additional, and Lopez, Margarita Reboredo, additional
- Published
- 2022
- Full Text
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438. Educación para la autogestión en lupus: consideraciones de un proceso en construcción para Latinoamérica
- Author
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Fuentes Silva, Yurilis, primary, Rodriguez Martin, Alberto, additional, Drenkard, Cristina, additional, and María Nay Valero, María Nay Valero, additional
- Published
- 2022
- Full Text
- View/download PDF
439. EPILEPTIC SEIZURE PREDICTION USING WAVELET TRANSFORM, FRACTAL DIMENSION, SUPPORT VECTOR MACHINE, AND EEG SIGNALS
- Author
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PEREZ-SANCHEZ, ANDREA V., primary, VALTIERRA-RODRIGUEZ, MARTIN, additional, PEREZ-RAMIREZ, CARLOS A., additional, DE-SANTIAGO-PEREZ, J. JESUS, additional, and AMEZQUITA-SANCHEZ, JUAN P., additional
- Published
- 2022
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440. Position paper on management of personal data in environment and health research in Europe
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Eva, Govarts, primary, Liese, Gilles, additional, Stephanie, Bopp, additional, Petr, Holub, additional, Leslie, Matalonga, additional, Roel, Vermeulen, additional, Martine, Vrijheid, additional, Sergi, Beltran, additional, Mette, Hartlev, additional, Sarah, Jones, additional, Laura, Rodriguez Martin, additional, Arnout, Standaert, additional, Morris A., Swertz, additional, Jan, Theunis, additional, Xenia, Trier, additional, Nina, Vogel, additional, Koert, Van Espen, additional, Sylvie, Remy, additional, and Greet, Schoeters, additional
- Published
- 2022
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441. Integrating knowledge and omics to decipher mechanisms via large‐scale models of signaling networks
- Author
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Garrido‐Rodriguez, Martin, primary, Zirngibl, Katharina, additional, Ivanova, Olga, additional, Lobentanzer, Sebastian, additional, and Saez‐Rodriguez, Julio, additional
- Published
- 2022
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442. Comparison of methods and resources for cell-cell communication inference from single-cell RNA-Seq data
- Author
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Dimitrov, Daniel, primary, Türei, Dénes, additional, Garrido-Rodriguez, Martin, additional, Burmedi, Paul L., additional, Nagai, James S., additional, Boys, Charlotte, additional, Ramirez Flores, Ricardo O., additional, Kim, Hyojin, additional, Szalai, Bence, additional, Costa, Ivan G., additional, Valdeolivas, Alberto, additional, Dugourd, Aurélien, additional, and Saez-Rodriguez, Julio, additional
- Published
- 2022
- Full Text
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443. Modeling of electric springs and their multi-objective voltage control based on continuous genetic algorithm for unbalanced distribution networks
- Author
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Tapia-Tinoco, Guillermo, primary, Granados-Lieberman, David, additional, Valtierra-Rodriguez, Martin, additional, Gabriel Avina-Cervantes, Juan, additional, and Garcia-Perez, Arturo, additional
- Published
- 2022
- Full Text
- View/download PDF
444. VISCOELASTIC TESTING IN CARDIAC SURGERY
- Author
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RODRIGUEZ MARTIN, I., primary
- Published
- 2022
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445. Harmonization of Human Biomonitoring Studies in Europe: Characteristics of the HBM4EU-Aligned Studies Participants
- Author
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Gilles, Liese, primary, Govarts, Eva, additional, Rodriguez Martin, Laura, additional, Andersson, Anna-Maria, additional, Appenzeller, Brice M. R., additional, Barbone, Fabio, additional, Castaño, Argelia, additional, Coertjens, Dries, additional, Den Hond, Elly, additional, Dzhedzheia, Vazha, additional, Eržen, Ivan, additional, López, Marta Esteban, additional, Fábelová, Lucia, additional, Fillol, Clémence, additional, Franken, Carmen, additional, Frederiksen, Hanne, additional, Gabriel, Catherine, additional, Haug, Line Småstuen, additional, Horvat, Milena, additional, Halldórsson, Thórhallur Ingi, additional, Janasik, Beata, additional, Holcer, Nataša Janev, additional, Kakucs, Réka, additional, Karakitsios, Spyros, additional, Katsonouri, Andromachi, additional, Klánová, Jana, additional, Kold-Jensen, Tina, additional, Kolossa-Gehring, Marike, additional, Konstantinou, Corina, additional, Koponen, Jani, additional, Lignell, Sanna, additional, Lindroos, Anna Karin, additional, Makris, Konstantinos C., additional, Mazej, Darja, additional, Morrens, Bert, additional, Murínová, Ľubica Palkovičová, additional, Namorado, Sónia, additional, Pedraza-Diaz, Susana, additional, Peisker, Jasmin, additional, Probst-Hensch, Nicole, additional, Rambaud, Loïc, additional, Rosolen, Valentina, additional, Rucic, Enrico, additional, Rüther, Maria, additional, Sarigiannis, Dimosthenis, additional, Tratnik, Janja Snoj, additional, Standaert, Arnout, additional, Stewart, Lorraine, additional, Szigeti, Tamás, additional, Thomsen, Cathrine, additional, Tolonen, Hanna, additional, Eiríksdóttir, Ása, additional, Van Nieuwenhuyse, An, additional, Verheyen, Veerle J., additional, Vlaanderen, Jelle, additional, Vogel, Nina, additional, Wasowicz, Wojciech, additional, Weber, Till, additional, Zock, Jan-Paul, additional, Sepai, Ovnair, additional, and Schoeters, Greet, additional
- Published
- 2022
- Full Text
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446. Decomposition Approaches for a Capacitated Hub Problem
- Author
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Rodríguez-Martín, Inmaculada, Salazar-González, Juan-José, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Carbonell, Jaime G., editor, Siekmann, Jörg, editor, Lemaître, Christian, editor, Reyes, Carlos A., editor, and González, Jesús A., editor
- Published
- 2004
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447. Designing User Interfaces Tailored to the Current User’s Requirements in Real Time
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González Rodríguez, Martín, Pérez Pérez, J. Ramón, Paule Ruíz, M. Puerto, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Miesenberger, Klaus, editor, Klaus, Joachim, editor, Zagler, Wolfgang L., editor, and Burger, Dominique, editor
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- 2004
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448. The Features of Development in the Pacific Countries of the African, Caribbean and Pacific Group
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Cuenca Garcia, Eduardo, Rodriguez Martin, Jose Antonio, and Navarro Pabsdorf, Margarita
- Abstract
In this article we present a new proposal for the measurement of development, applied to the Pacific Countries of the African, Caribbean and Pacific Group (ACP), conditional on their insularity, and with privileged relations with the European Union. Our index has been constructed attending to the criteria defined in the Goals of the Millennium Declaration. For this purpose we will use the P2 distance method for the year 2007, the last year for which data are available. This index integrates socio-economic variables that permit a territorial ordering of the Pacific ACPs, in terms of those partial indicators.
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- 2010
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449. Tau phosphorylation affects its axonal transport and degradation
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Rodríguez-Martín, Teresa, Cuchillo-Ibáñez, Inmaculada, Noble, Wendy, Nyenya, Fanon, Anderton, Brian H., and Hanger, Diane P.
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- 2013
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450. Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig
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Rubanova, Y, Shi, R, Harrigan, C, Li, R, Wintersinger, J, Sahin, N, Deshwar, A, Dentro, S, Leshchiner, I, Gerstung, M, Jolly, C, Haase, K, Tarabichi, M, Yu, K, Gonzalez, S, Macintyre, G, Adams, D, Anur, P, Beroukhim, R, Boutros, P, Bowtell, D, Campbell, P, Cao, S, Christie, E, Cmero, M, Cun, Y, Dawson, K, Demeulemeester, J, Donmez, N, Drews, R, Eils, R, Fan, Y, Fittall, M, Garsed, D, Getz, G, Ha, G, Imielinski, M, Jerman, L, Ji, Y, Kleinheinz, K, Lee, J, Lee-Six, H, Livitz, D, Malikic, S, Markowetz, F, Martincorena, I, Mitchell, T, Mustonen, V, Oesper, L, Peifer, M, Peto, M, Raphael, B, Rosebrock, D, Sahinalp, S, Salcedo, A, Schlesner, M, Schumacher, S, Sengupta, S, Shin, S, Spiro, O, Stein, L, Vazquez-Garcia, I, Vembu, S, Wheeler, D, Yang, T, Yao, X, Yuan, K, Zhu, H, Wang, W, Morris, Q, Spellman, P, Wedge, D, Van Loo, P, Aaltonen, L, Abascal, F, Abeshouse, A, Aburatani, H, Agrawal, N, Ahn, K, Ahn, S, Aikata, H, Akbani, R, Akdemir, K, Al-Ahmadie, H, Al-Sedairy, S, Al-Shahrour, F, Alawi, M, Albert, M, Aldape, K, Alexandrov, L, Ally, A, Alsop, K, Alvarez, E, Amary, F, Amin, S, Aminou, B, Ammerpohl, O, Anderson, M, Ang, Y, Antonello, D, Aparicio, S, Appelbaum, E, Arai, Y, Aretz, A, Arihiro, K, Ariizumi, S, Armenia, J, Arnould, L, Asa, S, Assenov, Y, Atwal, G, Aukema, S, Auman, J, Aure, M, Awadalla, P, Aymerich, M, Bader, G, Baez-Ortega, A, Bailey, M, Bailey, P, Balasundaram, M, Balu, S, Bandopadhayay, P, Banks, R, Barbi, S, Barbour, A, Barenboim, J, Barnholtz-Sloan, J, Barr, H, Barrera, E, Bartlett, J, Bartolome, J, Bassi, C, Bathe, O, Baumhoer, D, Bavi, P, Baylin, S, Bazant, W, Beardsmore, D, Beck, T, Behjati, S, Behren, A, Niu, B, Bell, C, Beltran, S, Benz, C, Berchuck, A, Bergmann, A, Bergstrom, E, Berman, B, Berney, D, Bernhart, S, Berrios, M, Bersani, S, Bertl, J, Betancourt, M, Bhandari, V, Bhosle, S, Biankin, A, Bieg, M, Bigner, D, Binder, H, Birney, E, Birrer, M, Biswas, N, Bjerkehagen, B, Bodenheimer, T, Boice, L, Bonizzato, G, De Bono, J, Boot, A, Bootwalla, M, Borg, A, Borkhardt, A, Boroevich, K, Borozan, I, Borst, C, Bosenberg, M, Bosio, M, Boultwood, J, Bourque, G, Bova, G, Bowen, D, Bowlby, R, Boyault, S, Boyce, R, Boyd, J, Brazma, A, Brennan, P, Brewer, D, Brinkman, A, Bristow, R, Broaddus, R, Brock, J, Brock, M, Broeks, A, Brooks, A, Brooks, D, Brors, B, Brunak, S, Bruxner, T, Bruzos, A, Buchanan, A, Buchhalter, I, Buchholz, C, Bullman, S, Burke, H, Burkhardt, B, Burns, K, Busanovich, J, Bustamante, C, Butler, A, Butte, A, Byrne, N, Borresen-Dale, A, Caesar-Johnson, S, Cafferkey, A, Cahill, D, Calabrese, C, Caldas, C, Calvo, F, Camacho, N, Campo, E, Cantu, C, Carey, T, Carlevaro-Fita, J, Carlsen, R, Cataldo, I, Cazzola, M, Cebon, J, Cerfolio, R, Chadwick, D, Chakravarty, D, Chalmers, D, Chan, C, Chan, K, Chan-Seng-Yue, M, Chandan, V, Chang, D, Chanock, S, Chantrill, L, Chateigner, A, Chatterjee, N, Chayama, K, Chen, H, Chen, J, Chen, K, Chen, Y, Chen, Z, Cherniack, A, Chien, J, Chiew, Y, Chin, S, Cho, J, Cho, S, Choi, J, Choi, W, Chomienne, C, Chong, Z, Choo, S, Chou, A, Christ, A, Chuah, E, Cibulskis, C, Cibulskis, K, Cingarlini, S, Clapham, P, Claviez, A, Cleary, S, Cloonan, N, Collins, C, Connor, A, Cooke, S, Cooper, C, Cope, L, Corbo, V, Cordes, M, Cordner, S, Cortes-Ciriano, I, Covington, K, Cowin, P, Craft, B, Craft, D, Creighton, C, Curley, E, Cutcutache, I, Czajka, K, Czerniak, B, Dagg, R, Danilova, L, Davi, M, Davidson, N, Davies, H, Davis, I, Davis-Dusenbery, B, De La Vega, F, De Paoli-Iseppi, R, Defreitas, T, Tos, A, Delaneau, O, Demchok, J, Demidov, G, Demircioglu, D, Dennis, N, Denroche, R, Desai, N, Deshpande, V, Desmedt, C, Deu-Pons, J, Dhalla, N, Dhani, N, Dhingra, P, Dhir, R, Dibiase, A, Diamanti, K, Ding, L, Ding, S, Dinh, H, Dirix, L, Doddapaneni, H, Dow, M, Drapkin, R, Drechsel, O, Serge, S, Dudderidge, T, Dueso-Barroso, A, Dunford, A, Dunn, M, Dursi, L, Duthie, F, Dutton-Regester, K, Eagles, J, Easton, D, Edmonds, S, Edwards, P, Edwards, S, Eeles, R, Ehinger, A, Eils, J, El-Naggar, A, Eldridge, M, Ellrott, K, Erkek, S, Escaramis, G, Espiritu, S, Estivill, X, Etemadmoghadam, D, Eyfjord, J, Faltas, B, Fan, D, Faquin, W, Farcas, C, Fassan, M, Fatima, A, Favero, F, Fayzullaev, N, Felau, I, Fereday, S, Ferguson, M, Ferretti, V, Feuerbach, L, Field, M, Fink, J, Finocchiaro, G, Fisher, C, Fitzgerald, A, Fitzgerald, R, Flanagan, A, Fleshner, N, Flicek, P, Foekens, J, Fong, K, Fonseca, N, Foster, C, Fox, N, Fraser, M, Frazer, S, Frenkel-Morgenstern, M, Friedman, W, Frigola, J, Fronick, C, Fujimoto, A, Fujita, M, Fukayama, M, Fulton, L, Fulton, R, Furuta, M, Futreal, P, Fullgrabe, A, Gabriel, S, Gallinger, S, Gambacorti-Passerini, C, Gao, J, Gao, S, Garraway, L, Garred, O, Garrison, E, Gehlenborg, N, Gelpi, J, George, J, Gerhard, D, Gerhauser, C, Gershenwald, J, Gerstein, M, Ghori, M, Ghossein, R, Giama, N, Gibbs, R, Gibson, B, Gill, A, Gill, P, Giri, D, Glodzik, D, Gnanapragasam, V, Goebler, M, Goldman, M, Gomez, C, Gonzalez-Perez, A, Gordenin, D, Gossage, J, Gotoh, K, Govindan, R, Grabau, D, Graham, J, Grant, R, Green, A, Green, E, Greger, L, Grehan, N, Grimaldi, S, Grimmond, S, Grossman, R, Grundhoff, A, Gundem, G, Guo, Q, Gupta, M, Gupta, S, Gut, I, Gut, M, Goke, J, Haake, A, Haan, D, Haas, S, Haber, J, Habermann, N, Hach, F, Haider, S, Hama, N, Hamdy, F, Hamilton, A, Hamilton, M, Han, L, Hanna, G, Hansmann, M, Haradhvala, N, Harismendy, O, Harliwong, I, Harmanci, A, Harrington, E, Hasegawa, T, Haussler, D, Hawkins, S, Hayami, S, Hayashi, S, Hayes, D, Hayes, S, Hayward, N, Hazell, S, He, Y, Heath, A, Heath, S, Hedley, D, Hegde, A, Heiman, D, Heinold, M, Heins, Z, Heisler, L, Hellstrom-Lindberg, E, Helmy, M, Heo, S, Hepperla, A, Heredia-Genestar, J, Herrmann, C, Hersey, P, Hess, J, Hilmarsdottir, H, Hinton, J, Hirano, S, Hiraoka, N, Hoadley, K, Hobolth, A, Hodzic, E, Hoell, J, Hoffmann, S, Hofmann, O, Holbrook, A, Holik, A, Hollingsworth, M, Holmes, O, Holt, R, Hong, C, Hong, E, Hong, J, Hooijer, G, Hornshoj, H, Hosoda, F, Hou, Y, Hovestadt, V, Howat, W, Hoyle, A, Hruban, R, Hu, J, Hu, T, Hua, X, Huang, K, Huang, M, Huang, V, Huang, Y, Huber, W, Hudson, T, Hummel, M, Hung, J, Huntsman, D, Hupp, T, Huse, J, Huska, M, Hutter, B, Hutter, C, Hubschmann, D, Iacobuzio-Donahue, C, Imbusch, C, Imoto, S, Isaacs, W, Isaev, K, Ishikawa, S, Iskar, M, Islam, S, Ittmann, M, Ivkovic, S, Izarzugaza, J, Jacquemier, J, Jakrot, V, Jamieson, N, Jang, G, Jang, S, Jayaseelan, J, Jayasinghe, R, Jefferys, S, Jegalian, K, Jennings, J, Jeon, S, Jiao, W, Johansson, P, Johns, A, Johns, J, Johnson, R, Johnson, T, Joly, Y, Jonasson, J, Jones, C, Jones, D, Jones, N, Jones, S, Jonkers, J, Y. S., J, Juhl, H, Jung, J, Juul, M, Juul, R, Juul, S, Jager, N, Kabbe, R, Kahles, A, Kahraman, A, Kaiser, V, Kakavand, H, Kalimuthu, S, von Kalle, C, Kang, K, Karaszi, K, Karlan, B, Karlic, R, Karsch, D, Kasaian, K, Kassahn, K, Katai, H, Kato, M, Katoh, H, Kawakami, Y, Kay, J, Kazakoff, S, Kazanov, M, Keays, M, Kebebew, E, Kefford, R, Kellis, M, Kench, J, Kennedy, C, Kerssemakers, J, Khoo, D, Khoo, V, Khuntikeo, N, Khurana, E, Kilpinen, H, Kim, H, Kim, J, Kim, Y, King, T, Klapper, W, Klimczak, L, Knappskog, S, Kneba, M, Knoppers, B, Koh, Y, Komorowski, J, Komura, D, Komura, M, Kong, G, Kool, M, Korbel, J, Korchina, V, Korshunov, A, Koscher, M, Koster, R, Kote-Jarai, Z, Koures, A, Kovacevic, M, Kremeyer, B, Kretzmer, H, Kreuz, M, Krishnamurthy, S, Kube, D, Kumar, K, Kumar, P, Kumar, S, Kumar, Y, Kundra, R, Kubler, K, Kuppers, R, Lagergren, J, Lai, P, Laird, P, Lakhani, S, Lalansingh, C, Lalonde, E, Lamaze, F, Lambert, A, Lander, E, Landgraf, P, Landoni, L, Langerod, A, Lanzos, A, Larsimont, D, Larsson, E, Lathrop, M, Lau, L, Lawerenz, C, Lawlor, R, Lawrence, M, Lazar, A, Lazic, A, Le, X, Lee, D, Lee, E, Lee, H, Lee, M, Lehmann, K, Lehrach, H, Lenze, D, Leonard, C, Leongamornlert, D, Letourneau, L, Letunic, I, Levine, D, Lewis, L, Ley, T, Li, C, C. 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S, Yakneen, S, Yamaguchi, R, Yamaguchi, T, Yamamoto, M, Yamamoto, S, Yamaue, H, Yang, F, Yang, H, Yang, J, Yang, L, Yang, S, Yang, Y, Yaspo, M, Yates, L, Yau, C, Ye, C, Ye, K, Yellapantula, V, Yoon, C, Yoon, S, Yousif, F, Yu, J, Yu, W, Yu, Y, Yuan, Y, Yuen, D, Yung, C, Zaikova, O, Zamora, J, Zapatka, M, Zenklusen, J, Zenz, T, Zeps, N, Zhang, C, Zhang, F, Zhang, H, Zhang, J, Zhang, X, Zhang, Y, Zhang, Z, Zhao, Z, Zheng, L, Zheng, X, Zhou, W, Zhou, Y, Zhu, B, Zhu, J, Zhu, S, Zou, L, Zou, X, Defazio, A, van As, N, van Deurzen, C, van de Vijver, M, van't Veer, L, von Mering, C, Rubanova Y., Shi R., Harrigan C. F., Li R., Wintersinger J., Sahin N., Deshwar A. G., Dentro S. C., Leshchiner I., Gerstung M., Jolly C., Haase K., Tarabichi M., Yu K., Gonzalez S., Macintyre G., Adams D. J., Anur P., Beroukhim R., Boutros P. C., Bowtell D. D., Campbell P. J., Cao S., Christie E. L., Cmero M., Cun Y., Dawson K. J., Demeulemeester J., Donmez N., Drews R. M., Eils R., Fan Y., Fittall M., Garsed D. W., Getz G., Ha G., Imielinski M., Jerman L., Ji Y., Kleinheinz K., Lee J., Lee-Six H., Livitz D. G., Malikic S., Markowetz F., Martincorena I., Mitchell T. J., Mustonen V., Oesper L., Peifer M., Peto M., Raphael B. J., Rosebrock D., Sahinalp S. C., Salcedo A., Schlesner M., Schumacher S., Sengupta S., Shin S. J., Spiro O., Stein L. D., Vazquez-Garcia I., Vembu S., Wheeler D. A., Yang T. -P., Yao X., Yuan K., Zhu H., Wang W., Morris Q. D., Spellman P. T., Wedge D. C., Van Loo P., Aaltonen L. A., Abascal F., Abeshouse A., Aburatani H., Agrawal N., Ahn K. S., Ahn S. -M., Aikata H., Akbani R., Akdemir K. C., Al-Ahmadie H., Al-Sedairy S. T., Al-Shahrour F., Alawi M., Albert M., Aldape K., Alexandrov L. B., Ally A., Alsop K., Alvarez E. G., Amary F., Amin S. B., Aminou B., Ammerpohl O., Anderson M. J., Ang Y., Antonello D., Aparicio S., Appelbaum E. L., Arai Y., Aretz A., Arihiro K., Ariizumi S. -I., Armenia J., Arnould L., Asa S., Assenov Y., Atwal G., Aukema S., Auman J. T., Aure M. R. R., Awadalla P., Aymerich M., Bader G. D., Baez-Ortega A., Bailey M. H., Bailey P. J., Balasundaram M., Balu S., Bandopadhayay P., Banks R. E., Barbi S., Barbour A. P., Barenboim J., Barnholtz-Sloan J., Barr H., Barrera E., Bartlett J., Bartolome J., Bassi C., Bathe O. F., Baumhoer D., Bavi P., Baylin S. B., Bazant W., Beardsmore D., Beck T. A., Behjati S., Behren A., Niu B., Bell C., Beltran S., Benz C., Berchuck A., Bergmann A. K., Bergstrom E. N., Berman B. P., Berney D. M., Bernhart S. H., Berrios M., Bersani S., Bertl J., Betancourt M., Bhandari V., Bhosle S. G., Biankin A. V., Bieg M., Bigner D., Binder H., Birney E., Birrer M., Biswas N. K., Bjerkehagen B., Bodenheimer T., Boice L., Bonizzato G., De Bono J. S., Boot A., Bootwalla M. S., Borg A., Borkhardt A., Boroevich K. A., Borozan I., Borst C., Bosenberg M., Bosio M., Boultwood J., Bourque G., Bova G. S., Bowen D. T., Bowlby R., Bowtell D. D. L., Boyault S., Boyce R., Boyd J., Brazma A., Brennan P., Brewer D. S., Brinkman A. B., Bristow R. G., Broaddus R. R., Brock J. E., Brock M., Broeks A., Brooks A. N., Brooks D., Brors B., Brunak S., Bruxner T. J. C., Bruzos A. L., Buchanan A., Buchhalter I., Buchholz C., Bullman S., Burke H., Burkhardt B., Burns K. H., Busanovich J., Bustamante C. D., Butler A. P., Butte A. J., Byrne N. J., Borresen-Dale A. -L., Caesar-Johnson S. J., Cafferkey A., Cahill D., Calabrese C., Caldas C., Calvo F., Camacho N., Campo E., Cantu C., Carey T. E., Carlevaro-Fita J., Carlsen R., Cataldo I., Cazzola M., Cebon J., Cerfolio R., Chadwick D. E., Chakravarty D., Chalmers D., Chan C. W. Y., Chan K., Chan-Seng-Yue M., Chandan V. S., Chang D. K., Chanock S. J., Chantrill L. A., Chateigner A., Chatterjee N., Chayama K., Chen H. -W., Chen J., Chen K., Chen Y., Chen Z., Cherniack A. D., Chien J., Chiew Y. -E., Chin S. -F., Cho J., Cho S., Choi J. K., Choi W., Chomienne C., Chong Z., Choo S. P., Chou A., Christ A. N., Chuah E., Cibulskis C., Cibulskis K., Cingarlini S., Clapham P., Claviez A., Cleary S., Cloonan N., Collins C. C., Connor A. A., Cooke S. L., Cooper C. S., Cope L., Corbo V., Cordes M. G., Cordner S. M., Cortes-Ciriano I., Covington K., Cowin P. A., Craft B., Craft D., Creighton C. J., Curley E., Cutcutache I., Czajka K., Czerniak B., Dagg R. A., Danilova L., Davi M. V., Davidson N. R., Davies H., Davis I. J., Davis-Dusenbery B. N., De La Vega F. M., De Paoli-Iseppi R., Defreitas T., Tos A. P. D., Delaneau O., Demchok J. A., Demidov G. M., Demircioglu D., Dennis N. M., Denroche R. E., Desai N., Deshpande V., Desmedt C., Deu-Pons J., Dhalla N., Dhani N. C., Dhingra P., Dhir R., DiBiase A., Diamanti K., Ding L., Ding S., Dinh H. Q., Dirix L., Doddapaneni H. V., Dow M. T., Drapkin R., Drechsel O., Serge S., Dudderidge T., Dueso-Barroso A., Dunford A. J., Dunn M., Dursi L. J., Duthie F. R., Dutton-Regester K., Eagles J., Easton D. F., Edmonds S., Edwards P. A., Edwards S. E., Eeles R. A., Ehinger A., Eils J., El-Naggar A., Eldridge M., Ellrott K., Erkek S., Escaramis G., Espiritu S. M. G., Estivill X., Etemadmoghadam D., Eyfjord J. E., Faltas B. M., Fan D., Faquin W. C., Farcas C., Fassan M., Fatima A., Favero F., Fayzullaev N., Felau I., Fereday S., Ferguson M. L., Ferretti V., Feuerbach L., Field M. A., Fink J. L., Finocchiaro G., Fisher C., Fittall M. W., Fitzgerald A., Fitzgerald R. C., Flanagan A. M., Fleshner N. E., Flicek P., Foekens J. A., Fong K. M., Fonseca N. A., Foster C. S., Fox N. S., Fraser M., Frazer S., Frenkel-Morgenstern M., Friedman W., Frigola J., Fronick C. C., Fujimoto A., Fujita M., Fukayama M., Fulton L. A., Fulton R. S., Furuta M., Futreal P. A., Fullgrabe A., Gabriel S. B., Gallinger S., Gambacorti-Passerini C., Gao J., Gao S., Garraway L., Garred O., Garrison E., Gehlenborg N., Gelpi J. L. L., George J., Gerhard D. S., Gerhauser C., Gershenwald J. E., Gerstein M., Ghori M., Ghossein R., Giama N. H., Gibbs R. A., Gibson B., Gill A. J., Gill P., Giri D. D., Glodzik D., Gnanapragasam V. J., Goebler M. E., Goldman M. J., Gomez C., Gonzalez-Perez A., Gordenin D. A., Gossage J., Gotoh K., Govindan R., Grabau D., Graham J. S., Grant R. C., Green A. R., Green E., Greger L., Grehan N., Grimaldi S., Grimmond S. M., Grossman R. L., Grundhoff A., Gundem G., Guo Q., Gupta M., Gupta S., Gut I. G., Gut M., Goke J., Haake A., Haan D., Haas S., Haber J. E., Habermann N., Hach F., Haider S., Hama N., Hamdy F. C., Hamilton A., Hamilton M. P., Han L., Hanna G. B., Hansmann M., Haradhvala N. J., Harismendy O., Harliwong I., Harmanci A. O., Harrington E., Hasegawa T., Haussler D., Hawkins S., Hayami S., Hayashi S., Hayes D. N., Hayes S. J., Hayward N. K., Hazell S., He Y., Heath A. P., Heath S. C., Hedley D., Hegde A. M., Heiman D. I., Heinold M. C., Heins Z., Heisler L. E., Hellstrom-Lindberg E., Helmy M., Heo S. G., Hepperla A. J., Heredia-Genestar J. M., Herrmann C., Hersey P., Hess J. M., Hilmarsdottir H., Hinton J., Hirano S., Hiraoka N., Hoadley K. A., Hobolth A., Hodzic E., Hoell J. I., Hoffmann S., Hofmann O., Holbrook A., Holik A. Z., Hollingsworth M. A., Holmes O., Holt R. A., Hong C., Hong E. P., Hong J. H., Hooijer G. K., Hornshoj H., Hosoda F., Hou Y., Hovestadt V., Howat W., Hoyle A. P., Hruban R. H., Hu J., Hu T., Hua X., Huang K. -L., Huang M., Huang M. N., Huang V., Huang Y., Huber W., Hudson T. J., Hummel M., Hung J. A., Huntsman D., Hupp T. R., Huse J., Huska M. R., Hutter B., Hutter C. M., Hubschmann D., Iacobuzio-Donahue C. A., Imbusch C. D., Imoto S., Isaacs W. B., Isaev K., Ishikawa S., Iskar M., Islam S. M. A., Ittmann M., Ivkovic S., Izarzugaza J. M. G., Jacquemier J., Jakrot V., Jamieson N. B., Jang G. H., Jang S. J., Jayaseelan J. C., Jayasinghe R., Jefferys S. R., Jegalian K., Jennings J. L., Jeon S. -H., Jiao W., Johansson P. A., Johns A. L., Johns J., Johnson R., Johnson T. A., Joly Y., Jonasson J. G., Jones C. D., Jones D. R., Jones D. T. W., Jones N., Jones S. J. M., Jonkers J., Ju Y. S., Juhl H., Jung J., Juul M., Juul R. I., Juul S., Jager N., Kabbe R., Kahles A., Kahraman A., Kaiser V. B., Kakavand H., Kalimuthu S., von Kalle C., Kang K. J., Karaszi K., Karlan B., Karlic R., Karsch D., Kasaian K., Kassahn K. S., Katai H., Kato M., Katoh H., Kawakami Y., Kay J. D., Kazakoff S. H., Kazanov M. D., Keays M., Kebebew E., Kefford R. F., Kellis M., Kench J. G., Kennedy C. J., Kerssemakers J. N. A., Khoo D., Khoo V., Khuntikeo N., Khurana E., Kilpinen H., Kim H. K., Kim H. -L., Kim H. -Y., Kim H., Kim J., Kim J. K., Kim Y., King T. A., Klapper W., Klimczak L. J., Knappskog S., Kneba M., Knoppers B. M., Koh Y., Jan Komorowski, Komura D., Komura M., Kong G., Kool M., Korbel J. O., Korchina V., Korshunov A., Koscher M., Koster R., Kote-Jarai Z., Koures A., Kovacevic M., Kremeyer B., Kretzmer H., Kreuz M., Krishnamurthy S., Kube D., Kumar K., Kumar P., Kumar S., Kumar Y., Kundra R., Kubler K., Kuppers R., Lagergren J., Lai P. H., Laird P. W., Lakhani S. R., Lalansingh C. M., Lalonde E., Lamaze F. C., Lambert A., Lander E., Landgraf P., Landoni L., Langerod A., Lanzos A., Larsimont D., Larsson E., Lathrop M., Lau L. M. S., Lawerenz C., Lawlor R. T., Lawrence M. S., Lazar A. J., Lazic A. M., Le X., Lee D., Lee E. A., Lee H. J., Lee J. J. -K., Lee J. -Y., Lee M. T. M., Lehmann K. -V., Lehrach H., Lenze D., Leonard C. R., Leongamornlert D. A., Letourneau L., Letunic I., Levine D. A., Lewis L., Ley T., Li C., Li C. H., Li H. I., Li J., Li L., Li S., Li X., Li Y., Liang H., Liang S. -B., Lichter P., Lin P., Lin Z., Linehan W. M., Lingjaerde O. C., Liu D., Liu E. M., Liu F. -F. F., Liu F., Liu J., Liu X., Livingstone J., Livitz D., Livni N., Lochovsky L., Loeffler M., Long G. V., Lopez-Guillermo A., Lou S., Louis D. N., Lovat L. B., Lu Y., Lu Y. -J., Luchini C., Lungu I., Luo X., Luxton H. J., Lynch A. G., Lype L., Lopez C., Lopez-Otin C., Ma E. Z., Ma Y., MacGrogan G., MacRae S., Madsen T., Maejima K., Mafficini A., Maglinte D. T., Maitra A., Majumder P. P., Malcovati L., Malleo G., Mann G. J., Mantovani-Loffler L., Marchal K., Marchegiani G., Mardis E. R., Margolin A. A., Marin M. G., Markowski J., Marks J., Marques-Bonet T., Marra M. A., Marsden L., Martens J. W. M., Martin S., Martin-Subero J. I., Martinez-Fundichely A., Maruvka Y. E., Mashl R. J., Massie C. E., Matthew T. J., Matthews L., Mayer E., Mayes S., Mayo M., Mbabaali F., McCune K., McDermott U., McGillivray P. D., McLellan M. D., McPherson J. D., McPherson J. R., McPherson T. A., Meier S. R., Meng A., Meng S., Menzies A., Merrett N. D., Merson S., Meyerson M., Meyerson W., Mieczkowski P. A., Mihaiescu G. L., Mijalkovic S., Mikkelsen T., Milella M., Mileshkin L., Miller C. A., Miller D. K., Miller J. K., Mills G. B., Milovanovic A., Minner S., Miotto M., Arnau G. M., Mirabello L., Mitchell C., Miyano S., Miyoshi N., Mizuno S., Molnar-Gabor F., Moore M. J., Moore R. A., Morganella S., Morrison C., Mose L. E., Moser C. D., Muinos F., Mularoni L., Mungall A. J., Mungall K., Musgrove E. A., Mutch D., Muyas F., Muzny D. M., Munoz A., Myers J., Myklebost O., Moller P., Nagae G., Nagrial A. M., Nahal-Bose H. K., Nakagama H., Nakagawa H., Nakamura H., Nakamura T., Nakano K., Nandi T., Nangalia J., Nastic M., Navarro A., Navarro F. C. P., Neal D. E., Nettekoven G., Newell F., Newhouse S. J., Newton Y., Ng A. W. T., Ng A., Nicholson J., Nicol D., Nie Y., Nielsen G. P., Nielsen M. M., Nik-Zainal S., Noble M. S., Nones K., Northcott P. A., Notta F., O'Connor B. D., O'Donnell P., O'Donovan M., O'Meara S., O'Neill B. P., O'Neill J. R., Ocana D., Ochoa A., Ogden C., Ohdan H., Ohi K., Ohno-Machado L., Oien K. A., Ojesina A. I., Ojima H., Okusaka T., Omberg L., Ong C. K., Ossowski S., Ott G., Ouellette B. F. F., P'ng C., Paczkowska M., Paiella S., Pairojkul C., Pajic M., Pan-Hammarstrom Q., Papaemmanuil E., Papatheodorou I., Paramasivam N., Park J. W., Park J. -W., Park K., Park P. J., Parker J. S., Parsons S. L., Pass H., Pasternack D., Pastore A., Patch A. -M., Pauporte I., Pea A., Pearson J. V., Pedamallu C. S., Pedersen J. S., Pederzoli P., Pennell N. A., Perou C. M., Perry M. D., Petersen G. M., Petrelli N., Petryszak R., Pfister S. M., Phillips M., Pich O., Pickett H. A., Pihl T. D., Pillay N., Pinder S., Pinese M., Pinho A. V., Pitkanen E., Pivot X., Pineiro-Yanez E., Planko L., Plass C., Polak P., Pons T., Popescu I., Potapova O., Prasad A., Preston S. R., Prinz M., Pritchard A. L., Prokopec S. D., Provenzano E., Puente X. S., Puig S., Puiggros M., Pulido-Tamayo S., Pupo G. M., Purdie C. A., Quinn M. C., Rabionet R., Rader J. S., Radlwimmer B., Radovic P., Raeder B., Raine K. M., Ramakrishna M., Ramakrishnan K., Ramalingam S., Rathmell W. K., Rausch T., Reifenberger G., Reimand J., Reis-Filho J., Reuter V., Reyes-Salazar I., Reyna M. A., Reynolds S. M., Rheinbay E., Riazalhosseini Y., Richardson A. L., Richter J., Ringel M., Ringner M., Rino Y., Rippe K., Roach J., Roberts L. R., Roberts N. D., Roberts S. A., Robertson A. G., Robertson A. J., Rodriguez J. B., Rodriguez-Martin B., Rodriguez-Gonzalez F. G., Roehrl M. H. A., Rohde M., Rokutan H., Romieu G., Rooman I., Roques T., Rosenberg M., Rosenstiel P. C., Rosenwald A., Rowe E. W., Royo R., Rozen S. G., Rubin M. A., Rubio-Perez C., Rudneva V. A., Rusev B. C., Ruzzenente A., Ratsch G., Sabarinathan R., Sabelnykova V. Y., Sadeghi S., Saini N., Saito-Adachi M., Saksena G., Salgado R., Salichos L., Sallari R., Saller C., Salvia R., Sam M., Samra J. S., Sanchez-Vega F., Sander C., Sanders G., Sarin R., Sarrafi I., Sasaki-Oku A., Sauer T., Sauter G., Saw R. P. M., Scardoni M., Scarlett C. J., Scarpa A., Scelo G., Schadendorf D., Schein J. E., Schilhabel M. B., Schlomm T., Schmidt H. K., Schramm S. -J., Schreiber S., Schultz N., Schumacher S. E., Schwarz R. F., Scolyer R. A., Scott D., Scully R., Seethala R., Segre A. V., Selander I., Semple C. A., Senbabaoglu Y., Sereni E., Serra S., Sgroi D. C., Shackleton M., Shah N. C., Shahabi S., Shang C. A., Shang P., Shapira O., Shelton T., Shen C., Shen H., Shepherd R., Shi Y., Shiah Y. -J., Shibata T., Shih J., Shimizu E., Shimizu K., Shiraishi Y., Shmaya T., Shmulevich I., Shorser S. I., Short C., Shrestha R., Shringarpure S. S., Shriver C., Shuai S., Sidiropoulos N., Siebert R., Sieuwerts A. M., Sieverling L., Signoretti S., Sikora K. O., Simbolo M., Simon R., Simons J. V., Simpson J. T., Simpson P. T., Singer S., Sinnott-Armstrong N., Sipahimalani P., Skelly T. J., Smid M., Smith J., Smith-McCune K., Socci N. D., Sofia H. J., Soloway M. G., Song L., Sood A. K., Sothi S., Sotiriou C., Soulette C. M., Span P. N., Sperandio N., Spillane A. J., Spring J., Staaf J., Stadler P. F., Staib P., Stark S. G., Stebbings L., Stefansson O. A., Stegle O., Stenhouse A., Stewart C., Stilgenbauer S., Stobbe M. D., Stratton M. R., Stretch J. R., Struck A. J., Stuart J. M., Stunnenberg H. G., Su H., Su X., Sun R. X., Sungalee S., Susak H., Suzuki A., Sweep F., Szczepanowski M., Sultmann H., Yugawa T., Tam A., Tamborero D., Tan B. K. T., Tan D., Tan P., Tanaka H., Taniguchi H., Tanskanen T. J., Tarnuzzer R., Tarpey P., Taschuk M. L., Tatsuno K., Tavare S., Taylor D. F., Taylor-Weiner A., Teague J. W., Teh B. T., Tembe V., Temes J., Thai K., Thayer S. P., Thiessen N., Thomas G., Thomas S., Thompson A., Thompson A. M., Thompson J. F. F., Thompson R. H., Thorne H., Thorne L. B., Thorogood A., Tiao G., Tijanic N., Timms L. E., Tirabosco R., Tojo M., Tommasi S., Toon C. W., Toprak U. H., Torrents D., Tortora G., Tost J., Totoki Y., Townend D., Traficante N., Treilleux I., Trotta J. -R., Trumper L. H. P., Tsao M., Tsunoda T., Tubio J. M. C., Tucker O., Turkington R., Turner D. J., Tutt A., Ueno M., Ueno N. T., Umbricht C., Umer H. M., Underwood T. J., Urban L., Urushidate T., Ushiku T., Uuskula-Reimand L., Valencia A., Van Den Berg D. J., Van Laere S., Van Meir E. G., Van den Eynden G. G., Van der Kwast T., Vasudev N., Vazquez M., Vedururu R., Veluvolu U., Verbeke L. P. C., Vermeulen P., Verrill C., Viari A., Vicente D., Vicentini C., VijayRaghavan K., Viksna J., Vilain R. E., Villasante I., Vincent-Salomon A., Visakorpi T., Voet D., Vyas P., Waddell N. M., Waddell N., Wadelius C., Wadi L., Wagener R., Wala J. A., Wang J., Wang L., Wang Q., Wang Y., Wang Z., Waring P. M., Warnatz H. -J., Warrell J., Warren A. Y., Waszak S. M., Weichenhan D., Weinberger P., Weinstein J. N., Weischenfeldt J., Weisenberger D. J., Welch I., Wendl M. C., Werner J., Whalley J. P., Whitaker H. C., Wigle D., Wilkerson M. D., Williams A., Wilmott J. S., Wilson G. W., Wilson J. M., Wilson R. K., Winterhoff B., Wintersinger J. A., Wiznerowicz M., Wolf S., Wong B. H., Wong T., Wong W., Woo Y., Wood S., Wouters B. G., Wright A. J., Wright D. W., Wright M. H., Wu C. -L., Wu D. -Y., Wu G., Wu J., Wu K., Wu Y., Wu Z., Xi L., Xia T., Xiang Q., Xiao X., Xing R., Xiong H., Xu Q., Xu Y., Xue H., Yachida S., Yakneen S., Yamaguchi R., Yamaguchi T. N., Yamamoto M., Yamamoto S., Yamaue H., Yang F., Yang H., Yang J. Y., Yang L., Yang S., Yang Y., Yaspo M. -L., Yates L., Yau C., Ye C., Ye K., Yellapantula V. D., Yoon C. J., Yoon S. -S., Yousif F., Yu J., Yu W., Yu Y., Yuan Y., Yuen D., Yung C. K., Zaikova O., Zamora J., Zapatka M., Zenklusen J. C., Zenz T., Zeps N., Zhang C. -Z., Zhang F., Zhang H., Zhang J., Zhang X., Zhang Y., Zhang Z., Zhao Z., Zheng L., Zheng X., Zhou W., Zhou Y., Zhu B., Zhu J., Zhu S., Zou L., Zou X., deFazio A., van As N., van Deurzen C. H. M., van de Vijver M. J., van't Veer L., and von Mering C.
- Abstract
The type and genomic context of cancer mutations depend on their causes. These causes have been characterized using signatures that represent mutation types that co-occur in the same tumours. However, it remains unclear how mutation processes change during cancer evolution due to the lack of reliable methods to reconstruct evolutionary trajectories of mutational signature activity. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole-genome sequencing data from 2658 cancers across 38 tumour types, we present TrackSig, a new method that reconstructs these trajectories using optimal, joint segmentation and deconvolution of mutation type and allele frequencies from a single tumour sample. In simulations, we find TrackSig has a 3–5% activity reconstruction error, and 12% false detection rate. It outperforms an aggressive baseline in situations with branching evolution, CNA gain, and neutral mutations. Applied to data from 2658 tumours and 38 cancer types, TrackSig permits pan-cancer insight into evolutionary changes in mutational processes.
- Published
- 2020
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