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401. Should we distinguish between intra and extrapericardial pulmonary artery involvement in NSCLC? A multicenter retrospective case-control study.

Author

Campisi, Alessio, Dell'Amore, Andrea, Chen, Chunji, Gabryel, Piotr, Bertolaccini, Luca, Ciarrocchi, Angelo Paolo, Ji, Chunyu, Piwkowski, Cezary, Spaggiari, Lorenzo, Fang, Wentao, and Rea, Federico

Subjects
PULMONARY artery, NON-small-cell lung carcinoma, OVERALL survival, CASE-control method, LUNGS
Abstract

T4 tumours comprise a heterogeneous group of locally invasive non-small cell lung cancers (NSCLC). Intrapericardial and extrapericardial involvement of the pulmonary artery (PA) may have a different prognosis. We compared the short and long-term surgery outcomes for NSCLC of the PA with intrapericardial or extrapericardial involvement. This is a multicenter retrospective study that included 129 patients who received an anatomical resection with PA resection and reconstruction in our centres between January 2000 and December 2018. Extrapericardial group included 70 patients, while the intrapericardial included 59. Differences in outcomes were found in terms of left side surgery (more common in extrapericardial, p = 0.010), type of lung resection (p < 0.001), Clavien-Dindo score (p = 0.012) and 90-day mortality (1.4 vs 16.9%, p = 0.002). Overall survival (OS, 91.11 ± 63.78 vs 63.78 ± 58.241 months, p = 0.008) and tumour-free survival (TFS, 68.17 ± 71.57 vs 45.44 ± 61.32 months, p = 0.007) were statistically different. OS stratification for performed pneumonectomy, pathological lymph node status and pattern of recurrence were statistically different (p = 0.017, 0.040, <0.001). Differences were found in terms of recurrence months stratified for recurrence pattern (p < 0.001). According to our results, the difference between PA involvement is significant in terms of survival and complications. A T4 subset or a shift to T3 for extrapericardial involvement of the PA may lead to a change in staging and surgical approach for these patients. [ABSTRACT FROM AUTHOR]

Published
2021
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405. MOESM1 of Multicenter randomized study on the comparison between electronic and traditional chest drainage systems

Author

Marulli, Giuseppe, Comacchio, Giovanni, Nosotti, Mario, Rosso, Lorenzo, Mendogni, Paolo, Natale, Giuseppe, Andriolo, Luigi, Imbriglio, Giovanna, Larocca, Valentina, Brascia, Debora, and Rea, Federico

Abstract

Additional file 1. SPIRIT 2013 Checklist: Recommended items to address in a clinical trial protocol and related documents.

Published
2019
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406. All-cause mortality and antipsychotic use among elderly persons with high baseline cardiovascular and cerebrovascular risk: a multi-center retrospective cohort study in Italy

Author

Sultana, Janet, Giorgianni, Francesco, Rea, Federico, Lucenteforte, Ersilia, Lombardi, Niccolò, Mugelli, Alessandro, Vannacci, Alfredo, Liperoti, Rosa, Kirchmayer, Ursula, Vitale, Cristiana, Chinellato, Alessandro, Roberto, Giuseppe, Corrao, Giovanni, and Trifirò, Gianluca

Abstract

Background: Little is known about the comparative risk of death with atypical or conventional antipsychotics (APs) among persons with cardiovascular or cerebrovascular disease (CCD). Research design and methods: A cohort study was conducted using five Italian claims databases. New atypical AP users with CCD aged ≥65 (reference) were matched to new conventional AP users. Mortality per 100 person-years (PYs) and hazard ratios (HR), estimated using Cox models, were reported. Incidence and risk of death were estimated for persons having drug–drug interactions. Outcome occurrence was evaluated 180 days after AP initiation. Results: Overall 24,711 and 27,051 elderly new conventional and atypical AP users were identified. The mortality rate was 51.3 and 38.5 deaths per 100 PYs for conventional and atypical AP users. Mortality risk was 1.33 (95%CI: 1.27–1.39) for conventional APs. There was no increased mortality risk with single drug–drug interactions (DDIs) vs. no DDI. AP users with ≥1 DDI had a 29% higher mortality risk compared to no DDI in the first 90 days of treatment (HR: 1.29 (95% CI: 1.00–1.67)). Conclusions: Conventional APs had a higher risk of death than atypical APs among elderly persons with CCD. Having ≥1 DDI was associated with an increased risk of death.

Published
2019
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412. A systematic review of case-identification algorithms based on italian healthcare administrative databases for three relevant diseases of the cardiovascular system: Acute myocardial infarction, ischemic heart disease, and stroke

Author

Hyeraci, G, Spini, A, Roberto, G, Gini, R, Bartolini, C, Lucenteforte, E, Corrao, G, Rea, F, Hyeraci, Giulia, Spini, Andrea, Roberto, Giuseppe, Gini, Rosa, Bartolini, Claudia, Lucenteforte, Ersilia, Corrao, Giovanni, Rea, Federico, Hyeraci, G, Spini, A, Roberto, G, Gini, R, Bartolini, C, Lucenteforte, E, Corrao, G, Rea, F, Hyeraci, Giulia, Spini, Andrea, Roberto, Giuseppe, Gini, Rosa, Bartolini, Claudia, Lucenteforte, Ersilia, Corrao, Giovanni, and Rea, Federico

Abstract

BACKGROUND: acute myocardial infarction (AMI), ischemic heart diseases (IHDs) and stroke are serious cardiovascular diseases (CVDs) which may lead to hospitalizations, require periodical medical monitoring and life-long drugs use, thus having a high impact on public health and Healthcare Service expenditure. In this contest, Italian Healthcare Administrative Databases (HADs), which routinely collect patient-level information on healthcare services reimbursed by the National Healthcare service, are increasingly used for identification of these CVDs. ObjectiveS: to identify and describe all AMI, IHDs and stroke case-identification algorithms by means of Italian HADs, through the review of papers published in the past 10 years. Methods: this study is part of a project that systematically reviewed case-identification algorithms for 18 acute and chronic conditions by means of HADs in Italy. PubMed was searched for original articles, published between 2007 and 2017, in Italian or English. The search string consisted of a combination of free text and MeSH terms with a common part that focused on HADs and a disease-specific part. All identified papers were screened by two independent reviewers. Pertinent papers were classified according to the objective for which the algorithm had been used, and only articles that used algorithms for primary objectives (I disease occurrence; II population/cohort selection; III outcome identification) were considered for algorithm extraction. The HADs used (hospital discharge records, drug prescriptions, etc.), ICD-9 and ICD-10 codes, ATC classification of drugs, follow-back periods, and age ranges applied by the algorithms have been reported. Further information on specific objective(s), accuracy measures, sensitivity analyses and the contribution of each HAD, have also been recorded. Results: the search strategy has led to the identification of 611 papers for AMI,801 for IHDs and 791 for stroke. Among these,45,12 and 31 papers for AMI, IHD

Published
2019

413. All-cause mortality and antipsychotic use among elderly persons with high baseline cardiovascular and cerebrovascular risk: a multi-center retrospective cohort study in Italy

Author

Sultana, J, Giorgianni, F, Rea, F, Lucenteforte, E, Lombardi, N, Mugelli, A, Vannacci, A, Liperoti, R, Kirchmayer, U, Vitale, C, Chinellato, A, Roberto, G, Corrao, G, Trifiro, G, Agabiti, N, Bartolini, C, Bernabei, R, Bettiol, A, Bonassi, S, Caputi, A, Cascini, S, Cipriani, F, Davoli, M, Fini, M, Gini, R, Lapi, F, Onder, G, Sorge, C, Tari, M, Vetrano, D, Sultana J., Giorgianni F., REA, FEDERICO, Lucenteforte E., Lombardi N., Mugelli A., Vannacci A., Liperoti R., Kirchmayer U., Vitale C., Chinellato A., Roberto G., Corrao G., Trifiro G., Agabiti N., Bartolini C., Bernabei R., Bettiol A., Bonassi S., Caputi A. P., Cascini S., Cipriani F., Davoli M., Fini M., Gini R., Lapi F., Onder G., Sorge C., Tari M., Vetrano D. L., Sultana, J, Giorgianni, F, Rea, F, Lucenteforte, E, Lombardi, N, Mugelli, A, Vannacci, A, Liperoti, R, Kirchmayer, U, Vitale, C, Chinellato, A, Roberto, G, Corrao, G, Trifiro, G, Agabiti, N, Bartolini, C, Bernabei, R, Bettiol, A, Bonassi, S, Caputi, A, Cascini, S, Cipriani, F, Davoli, M, Fini, M, Gini, R, Lapi, F, Onder, G, Sorge, C, Tari, M, Vetrano, D, Sultana J., Giorgianni F., REA, FEDERICO, Lucenteforte E., Lombardi N., Mugelli A., Vannacci A., Liperoti R., Kirchmayer U., Vitale C., Chinellato A., Roberto G., Corrao G., Trifiro G., Agabiti N., Bartolini C., Bernabei R., Bettiol A., Bonassi S., Caputi A. P., Cascini S., Cipriani F., Davoli M., Fini M., Gini R., Lapi F., Onder G., Sorge C., Tari M., and Vetrano D. L.

Abstract

Background: Little is known about the comparative risk of death with atypical or conventional antipsychotics (APs) among persons with cardiovascular or cerebrovascular disease (CCD). Research design and methods: A cohort study was conducted using five Italian claims databases. New atypical AP users with CCD aged ≥65 (reference) were matched to new conventional AP users. Mortality per 100 person-years (PYs) and hazard ratios (HR), estimated using Cox models, were reported. Incidence and risk of death were estimated for persons having drug–drug interactions. Outcome occurrence was evaluated 180 days after AP initiation. Results: Overall 24,711 and 27,051 elderly new conventional and atypical AP users were identified. The mortality rate was 51.3 and 38.5 deaths per 100 PYs for conventional and atypical AP users. Mortality risk was 1.33 (95%CI: 1.27–1.39) for conventional APs. There was no increased mortality risk with single drug–drug interactions (DDIs) vs. no DDI. AP users with ≥1 DDI had a 29% higher mortality risk compared to no DDI in the first 90 days of treatment (HR: 1.29 (95% CI: 1.00–1.67)). Conclusions: Conventional APs had a higher risk of death than atypical APs among elderly persons with CCD. Having ≥1 DDI was associated with an increased risk of death.

Published
2019

414. Adherence to clinical evaluations in women with pre-existing diabetes during pregnancy: A call to action from an Italian real-life investigation

Author

Cantarutti, A, Rea, F, Locatelli, A, Merlino, L, Lundin, R, Perseghin, G, Corrao, G, Cantarutti, Anna, Rea, Federico, Locatelli, Anna, Merlino, Luca, Lundin, Rebecca, Perseghin, Gianluca, Corrao, Giovanni, Cantarutti, A, Rea, F, Locatelli, A, Merlino, L, Lundin, R, Perseghin, G, Corrao, G, Cantarutti, Anna, Rea, Federico, Locatelli, Anna, Merlino, Luca, Lundin, Rebecca, Perseghin, Gianluca, and Corrao, Giovanni

Abstract

Aims: Women with pre-existing diabetes should plan for optimal care of the disease before, during and after pregnancy. The aim of this study was to assess the quality of diabetes mellitus monitoring and care before, during and after pregnancy in a large cohort of women. Methods: 1913 diabetic women resident in the Lombardy Region (Italy) who experienced at least a birth between 2011 and 2015 and exhibited signs of diabetes ≥2 years before delivery were identified using the healthcare utilization database. Antidiabetic care was defined via outpatient examinations (i.e., assessments of glycated haemoglobin, lipid profile, urine albumin excretion and serum creatinine, and dilated eye exams) and use of antidiabetic drugs. Differences in adherence to recommendations before, during and after pregnancy were assessed by the non-parametric McNemar's test among the whole cohort and among the subgroup with type 1 diabetes. Results: Adherence to recommendations was very poor before pregnancy, ranging from 13% to 42% for dilated eye and serum creatinine exam, respectively. During pregnancy, a significant portion of women increased adherence to all recommendations (e.g., glycated haemoglobin from 20% to 47%, p-value < 0.001), with the exception of lipid profile control. After pregnancy, adherence dropped to pre-pregnancy levels. A similar trend was observed in the use of antidiabetic drugs. Although women with type 1 diabetes showed better adherence across all periods, the same patterns emerged. Conclusions: Besides an improvement in the indicators of clinical adherence during pregnancy, the management of diabetes among pregnant women remains sub-optimal both before and after the birth.

Published
2019

415. Effectiveness of adherence to recommended clinical examinations of diabetic patients in preventing diabetes-related hospitalizations

Author

Corrao, G, Rea, F, DI Martino, M, Lallo, A, Davoli, M, DE Palma, R, Belotti, L, Merlino, L, Pisanti, P, Lispi, L, Skrami, E, Carle, F, Corrao, Giovanni, Rea, Federico, DI Martino, Mirko, Lallo, Adele, Davoli, Marina, DE Palma, Rossana, Belotti, Laura, Merlino, Luca, Pisanti, Paola, Lispi, Lucia, Skrami, Edlira, Carle, Flavia, Corrao, G, Rea, F, DI Martino, M, Lallo, A, Davoli, M, DE Palma, R, Belotti, L, Merlino, L, Pisanti, P, Lispi, L, Skrami, E, Carle, F, Corrao, Giovanni, Rea, Federico, DI Martino, Mirko, Lallo, Adele, Davoli, Marina, DE Palma, Rossana, Belotti, Laura, Merlino, Luca, Pisanti, Paola, Lispi, Lucia, Skrami, Edlira, and Carle, Flavia

Abstract

Objective: To validate a set of indicators for quality of diabetes care through their relationship with measurable clinical outcomes. Design: A retrospective cohort study was carried out from 2010 to 2015. Setting: Population-based study. Data were retrieved from healthcare utilization databases of three Italian regions (Lombardy, Emilia Romagna and Lazio) on the whole covering 20 million citizens. Participants: The 77 285 individuals who were newly taken in care for diabetes during 2010 entered into the cohort. Interventions: Exposure to selected clinical recommendations (i.e. periodic controls for glycated hemoglobin, lipid profile, urine albumin excretion, serum creatinine and dilated eye exams) was recorded. Main outcomes measures: A composite outcome was employed taking into account hospitalizations for brief-term diabetes complications, uncontrolled diabetes, long-term vascular outcomes and no traumatic lower limb amputation. A multivariable proportional hazards model was fitted to estimate hazard ratio, and 95% confidence intervals (CI), for the exposure-outcome association. Results: Among the newly taken in care patients with diabetes, those who adhered to almost none (0 or 1), just some (2 or 3) or almost all (4 or 5) recommendations during the first year after diagnosis were 44%, 36% and 20%, respectively. Compared patients who adhered to almost none recommendation, significant risk reductions of 16% (95% CI, 6-24%) and 20% (7-28%) were observed for those who adhered to just some and almost all recommendations, respectively. Conclusions: Tight control of patients with diabetes through regular clinical examinations must to be considered the cornerstone of national guidance, national audits and quality improvement incentives schemes.

Published
2019

416. The Role of European Healthcare Databases for Post-Marketing Drug Effectiveness, Safety and Value Evaluation: Where Does Italy Stand?

Author

Trifirò, G, Gini, R, Barone-Adesi, F, Beghi, E, Cantarutti, A, Capuano, A, Carnovale, C, Clavenna, A, Dellagiovanna, M, Ferrajolo, C, Franchi, M, Ingrasciotta, Y, Kirchmayer, U, Lapi, F, Leone, R, Leoni, O, Lucenteforte, E, Moretti, U, Mugelli, A, Naldi, L, Poluzzi, E, Rafaniello, C, Rea, F, Sultana, J, Tettamanti, M, Traversa, G, Vannacci, A, Mantovani, L, Corrao, G, Trifirò, Gianluca, Gini, Rosa, Barone-Adesi, Francesco, Beghi, Ettore, Cantarutti, Anna, Capuano, Annalisa, Carnovale, Carla, Clavenna, Antonio, Dellagiovanna, Mirosa, Ferrajolo, Carmen, Franchi, Matteo, Ingrasciotta, Ylenia, Kirchmayer, Ursula, Lapi, Francesco, Leone, Roberto, Leoni, Olivia, Lucenteforte, Ersilia, Moretti, Ugo, Mugelli, Alessandro, Naldi, Luigi, Poluzzi, Elisabetta, Rafaniello, Concita, Rea, Federico, Sultana, Janet, Tettamanti, Mauro, Traversa, Giuseppe, Vannacci, Alfredo, Mantovani, Lorenzo, Corrao, Giovanni, Trifirò, G, Gini, R, Barone-Adesi, F, Beghi, E, Cantarutti, A, Capuano, A, Carnovale, C, Clavenna, A, Dellagiovanna, M, Ferrajolo, C, Franchi, M, Ingrasciotta, Y, Kirchmayer, U, Lapi, F, Leone, R, Leoni, O, Lucenteforte, E, Moretti, U, Mugelli, A, Naldi, L, Poluzzi, E, Rafaniello, C, Rea, F, Sultana, J, Tettamanti, M, Traversa, G, Vannacci, A, Mantovani, L, Corrao, G, Trifirò, Gianluca, Gini, Rosa, Barone-Adesi, Francesco, Beghi, Ettore, Cantarutti, Anna, Capuano, Annalisa, Carnovale, Carla, Clavenna, Antonio, Dellagiovanna, Mirosa, Ferrajolo, Carmen, Franchi, Matteo, Ingrasciotta, Ylenia, Kirchmayer, Ursula, Lapi, Francesco, Leone, Roberto, Leoni, Olivia, Lucenteforte, Ersilia, Moretti, Ugo, Mugelli, Alessandro, Naldi, Luigi, Poluzzi, Elisabetta, Rafaniello, Concita, Rea, Federico, Sultana, Janet, Tettamanti, Mauro, Traversa, Giuseppe, Vannacci, Alfredo, Mantovani, Lorenzo, and Corrao, Giovanni

Abstract

Enormous progress has been made globally in the use of evidence derived from patients’ clinical information as they access their routine medical care. The value of real-world data lies in their complementary nature compared with data from randomised controlled trials: less detailed information on drug efficacy but longer observational periods and larger, more heterogeneous study populations reflecting clinical practice because individuals are included who would not usually be recruited in trials. Real-world data can be collected in various types of electronic sources, such as electronic health records, claims databases and drug or disease registries. These data sources vary in nature from country to country, according to national healthcare system structures and national policies. In Italy, a growing number of healthcare databases have been used to evaluate post-marketing drug utilisation and safety in the last two decades. The aim of this narrative review is to describe the available Italian sources of real-world data and their contribution to generating post-marketing evidence on drug use and safety. We also discuss the strengths and limitations of the most commonly used Italian healthcare databases in addressing various research questions concerning drug utilisation, comparative effectiveness and safety studies, as well as health technology assessment and other areas

Published
2019

417. Total Lung-sparing Surgery for Tracheobronchial Low-grade Malignancies.

Author

Dell'Amore, Andrea, Chen, Liang, Monaci, Nicola, Campisi, Alessio, Wang, Zhexin, Mammana, Marco, Pangoni, Alessandro, Zhao, Heng, Schiavon, Marco, Yao, Feng, and Rea, Federico

Abstract

Total lung-sparing tracheobronchial sleeve resections are a step forward in the treatment of low-grade bronchial tumors in which minimal resection margins are required to achieve complete control of the disease. This study retrospectively collected data on patients who underwent total lung-sparing procedures for low-grade tracheobronchial tumors at 2 thoracic surgical centers from January 1984 to October 2019. The study included 98 patients, 46 –female (47%) and 52 –male (53%), with a median age of 39 years (range, 7 to 70 years). Thirty-four patients underwent operative endoscopy before surgery (32 had laser treatment, and 2 had endobronchial stenting). The surgical resections were as follows: 9 (9%), tracheal carina; 18 (18%), second carina; 31 (32%), left main bronchi; 25 (26%), right main bronchi; and 15 (15%), intermediate bronchus. The median length of the resected bronchus was 2.2 cm. The median postoperative in-hospital stay was 8 days, and no perioperative mortality was observed. Postoperative complications were recorded in 26-patients (27%). The final histologic classification was as follows: 37 typical carcinoids (38%); 10 atypical carcinoids (10%); 29 adenoid cystic carcinomas (30%); 15 mucoepidermoid carcinomas (15%); 6 inflammatory myofibroblastic tumors (6%); and 1 glomic tumor (1%). Twenty-two patients had positive resection margins and underwent adjuvant radiotherapy. Three patients with adenoid cystic carcinoma had recurrences (1 local and 2 systemic). After a median follow-up time of 54.5 months (range, 4 to 360 months), the overall actuarial 5-year survival was 97%. Total lung-sparing tracheobronchial sleeve resection for low-grade malignant disease requires advanced surgical skills, but the hospital morbidity and mortality are very low. This technique is adequate and safe for highly selected patients with low-grade endobronchial malignant diseases, and its use should be encouraged in experienced centers. [ABSTRACT FROM AUTHOR]

Published
2021
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419. Gemcitabine combined with carboplatin in patients with malignant pleural mesothelioma: a multicentric phase II study

Author

Favaretto, Adolfo G., Aversa, Savina M.L., Paccagnella, Adriano, Manzini, Vincenzo De Pangher, Palmisano, Valentina, Oniga, Francesco, Stefani, Micaela, Rea, Federico, Bortolotti, Luigi, Loreggian, Lucio, and Monfardini, Silvio

Subjects
Gemcitabine -- Dosage and administration, Gemcitabine -- Evaluation, Carboplatin -- Dosage and administration, Carboplatin -- Evaluation, Mesothelioma -- Drug therapy, Mesothelioma -- Prognosis, Mesothelioma -- Patient outcomes, Health
Published
2003

420. Indications and Results of Sternal Allograft Transplantation: Learning From a Worldwide Experience.

Author

Dell'Amore, Andrea, Kalab, Martin, Miller III, Archibald Sandford, Dolci, Giampiero, Liparulo, Valeria, Beigee, Farahnaz Sadegh, Rosso, Lorenzo, Ferrigno, Pia, Pangoni, Alessandro, Schiavon, Marco, Bottio, Tommaso, Puma, Francesco, Lonsky, Vladimir, and Rea, Federico

Abstract

Reconstruction of the anterior chest wall defect after sternectomy is a challenge for cardiothoracic surgeons. In 2010, the Padua group published the first case of cadaveric sternum transplantation after sternectomy. This multicenter study reports the clinical indications and early and long-term results of sternal chondral allograft transplantation. This is a retrospective multicenter study from 7 academic centers. We collected demographic data, surgical indications, technical details, and early postoperative results. The complications, long-term stability, and tolerance of the allografts were also analyzed. Between January 2008 and December 2019, 58 patients underwent sternectomy followed by reconstruction using cadaveric-cryopreserved sternochondral allografts. Thirty-two patients were male, median age 63.5 years (interquartile range, 50-72 years). Indications for sternectomy were secondary sternal tumors (n = 13), primary sternal tumors (n = 15), and nonneoplastic disease (n = 30). Thirty patients underwent total sternectomy, 16 lower-body sternectomy, and 12 upper-body manubrium resection. The 30-day mortality was 5%; overall morbidity was 31%. Six early reoperations were necessary because of bleeding (n = 1), titanium plate dislocation (n = 1), and resuture of the skin in the lower part of the incision (n = 4). Overall, 5-year survival was 74%. In all the survived patients, the reconstructions were stable and free from mechanical or infective complications. The main indications for sternal allograft implantation were complex poststernotomy dehiscence followed by primary or secondary tumor involvement of the sternum. The collected results demonstrate that sternochondral allograft transplantation is a safe and effective method in reconstructing the anterior chest wall after sternectomy. Further studies to demonstrate the integration of the bone grafts into the patients' sternal wall will be made. [ABSTRACT FROM AUTHOR]

Published
2021
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422. Extended criteria donor lung reconditioning with the organ care system lung: a single institution experience

Author

Giulio Faggi, Emanuele Cozzi, Fiorella Calabrese, Guido Di Gregorio, Giovanni Maria Comacchio, Alessandro Rebusso, Marco Schiavon, Rea Federico, Dario Gregori, Giuseppe Marulli, Francesca Lunardi, and Paolo Feltracco

Subjects
Adult, Lung Diseases, Male, medicine.medical_specialty, Time Factors, Tissue and Organ Procurement, Adolescent, Critical Care, medicine.medical_treatment, Primary Graft Dysfunction, 030230 surgery, OCS lung, Extended criteria, 03 medical and health sciences, 0302 clinical medicine, Ischemia, ex vivo lung perfusion, medicine, Lung transplantation, Humans, Hospital Mortality, Postoperative Period, Mechanical ventilation, Transplantation, Lung, business.industry, Ex vivo lung perfusion, extended criteria donors, Organ Preservation, respiratory system, Length of Stay, Middle Aged, Respiration, Artificial, Tissue Donors, respiratory tract diseases, Surgery, Perfusion, Intensive Care Units, medicine.anatomical_structure, reconditioning, Treatment Outcome, 030211 gastroenterology & hepatology, Female, business, Lung Transplantation
Abstract

Lung transplantation is a life-saving procedure limited by donor's availability. Lung reconditioning by ex vivo lung perfusion represents a tool to expand the donor pool. In this study, we describe our experience with the OCS™ Lung to assess and recondition extended criteria lungs. From January 2014 to October 2016, of 86 on-site donors evaluated, eight lungs have been identified as potentially treatable with OCS™ Lung. We analyzed data from these donors and the recipient outcomes after transplantation. All donor lungs improved during OCS perfusion in particular regarding the PaO2 /FiO2 ratio (from 340 mmHg in donor to 537 mmHg in OCS) leading to lung transplantation in all cases. Concerning postoperative results, primary graft dysfunction score 3 at 72 h was observed in one patient, while median mechanical ventilation time, ICU, and hospital stay were 60 h, 14 and 36 days respectively. One in-hospital death was recorded (12.5%), while other two patients died during follow-up leading to 1-year survival of 62.5%. The remaining five patients are alive and in good conditions. This case series demonstrates the feasibility and value of lung reconditioning with the OCS™ Lung; a prospective trial is underway to validate its role to safely increase the number of donor lungs.

Published
2018

423. Supplementary_tables - Blood Products Transfusion and Mid-Term Outcomes of Lung Transplanted Patients Under Extracorporeal Membrane Oxygenation Support

Author

Pettenuzzo, Tommaso, Faggi, Giulio, Gregorio, Guido Di, Schiavon, Marco, Marulli, Giuseppe, Gregori, Dario, Rea, Federico, Ori, Carlo, and Feltracco, Paolo

Subjects
111099 Nursing not elsewhere classified, FOS: Clinical medicine, 110323 Surgery, FOS: Health sciences, 110305 Emergency Medicine
Abstract

Supplementary_tables for Blood Products Transfusion and Mid-Term Outcomes of Lung Transplanted Patients Under Extracorporeal Membrane Oxygenation Support by Tommaso Pettenuzzo, Giulio Faggi, Guido Di Gregorio, Marco Schiavon, Giuseppe Marulli, Dario Gregori, Federico Rea, Carlo Ori, and Paolo Feltracco in Progress in Transplantation

Published
2018
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424. NSAIDs utilization for musculoskeletal indications in elderly patients with cerebro/cardiovascular disease

Author

Roberto, G., Bartolini, C., Rea, Federico, Onder, G., Vitale, C., Trifirò, G., Kirchmayer, U., Chinellato, A., Lucenteforte, E., Corrao, G., Mugelli, A., Lapi, F., Gini, R., Agabiti, N., Bernabei, R., Bettiol, A., Bonassi, S., Caputi, A. P., Cascini, S., Davoli, M., Fini Storchi, Marco, Giorgianni, F., Lombardi, N., Rea, F., Sorge, C., Tari, M., Vannacci, A., Vetrano, D. L., Vitale, Claudia, Roberto, G, Bartolini, C, Rea, F, Onder, G, Vitale, C, Trifirò, G, Kirchmayer, U, Chinellato, A, Lucenteforte, E, Corrao, G, Mugelli, A, Lapi, F, Gini, R, On Behalf Of The Italian Group For Appropriate Drug Prescription In The Elderly (I-Grade): Agabiti, N, Bernabei, R, Bettiol, A, Bonassi, S, Caputi, A, Cascini, S, Davoli, M, Fini, M, Giorgianni, F, Lombardi, N, Sorge, C, Tari, M, Vannacci, A, and Vetrano, D

Subjects
Drug Utilization, medicine.medical_specialty, Diclofenac, Pharmacoepidemiology and Prescription, NSAIDs, Population, Psychological intervention, Cardiovascular risk Coxibs Diclofenac Drug utilization Elderly NSAIDs, Disease, 030204 cardiovascular system & hematology, Coxib, 03 medical and health sciences, 0302 clinical medicine, Elderly, Internal medicine, medicine, Coxibs, Drug utilization, Humans, Pharmacology (medical), Musculoskeletal Diseases, 030212 general & internal medicine, Medical prescription, education, Aged, Aged, 80 and over, Pharmacology, education.field_of_study, business.industry, Anti-Inflammatory Agents, Non-Steroidal, General Medicine, Cardiovascular risk, NSAID, Cardiovascular Diseases, Cohort, Female, business, Nimesulide, medicine.drug
Abstract

Objectives To describe NSAID utilization for musculoskeletal conditions in a large cohort of Italian elderly with cerebro/cardiovascular disease, a population in which NSAIDs should be generally avoided due to the prothrombotic potential. Methods Administrative data from five Italian geographic areas were analyzed. Patients aged ≥ 65 with a cerebro/cardiovascular event recorded between 2008 and 2011 (cohort entry) were selected. Prescription NSAIDs reimbursed for musculoskeletal conditions and dispensed during 1 year follow-up were retrieved to describe (i) prevalence of use, (ii) average amount of defined daily doses of NSAIDs claimed by users per day of follow-up, and (iii) distribution of the received daily dose (RDD) among patients with ≥ 2 dispensings. Among new users, i.e., patients without NSAID dispensings during 2 years before cohort entry, the first dispensed NSAID molecule was observed. Results Overall, 511,989 patients were selected. Across the five geographic areas, prevalence of use ranged from 48 to 21% and average consumption ranged between 30 and 67 DDD/1000 users/day. Around 10% of patients in the overall cohort had a RDD > 1. Nimesulide (9.6%) and diclofenac (7.5%) had the highest prevalence of use. The most consumed NSAIDs were nimesulide and coxibs with 10.6 and 7.5 DDD/1000 users/day, respectively. Among new users recruited in 2011, 30% had diclofenac or a coxibs as the first prescription. Conclusions NSAID use was common in the study cohort, particularly in central-southern areas. In contrast with current recommendations, coxibs and diclofenac were among the most prescribed active principles, even in new users. Interventions to promote appropriateness of use are warranted. Electronic supplementary material The online version of this article (10.1007/s00228-018-2411-y) contains supplementary material, which is available to authorized users.

Published
2018

425. Safety of nintedanib before lung transplant: an Italian case series

Author

Balestro, Elisabetta, Solidoro, Paolo, Parigi, Piercarlo, Boffini, Massimo, Lucianetti, Alessandro, and Rea, Federico

Subjects
Idiopathic pulmonary fibrosis, Lung transplant, Nintedanib, Pulmonary and Respiratory Medicine, lung transplant, nintedanib, Case Series, respiratory system, respiratory tract diseases
Abstract

Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal disease that can only be cured by lung transplantation. Pharmacological agents play a role in preserving lung function and prolonging survival until a suitable donor organ becomes available. However, data on the effects of newer antifibrotic therapies on lung transplantation outcomes in IPF patients are lacking. The nine patients included in this case series were treated with nintedanib 150 mg twice daily for 3–30 (mean 13 ± 9) months before lung transplant surgery. Lung function was relatively preserved during nintedanib therapy, and no acute IPF exacerbations occurred. Transplant surgery was generally uneventful; eight of the nine patients are still alive. There were no extraordinary bleeding complications or issues with postoperative thoracic wound healing or dehiscence. Only one patient experienced bronchial anastomotic stenosis a few months later. In conclusion, nintedanib preserved lung function up to transplantation, was well tolerated, and had no detrimental effects on the short‐term outcome of lung transplant.

Published
2018

430. Revised UIP/IPF diagnoses after the 2018 international guidelines: a 15-year Padova-Strasbourg experience

Author

Calabrese, Fiorella, primary, Lunardi, Francesca, additional, Balestro, Elisabetta, additional, Cocconcelli, Elisabetta, additional, Giraudo, Chiara, additional, Polverosi, Roberta, additional, Faccioli, Eleonora, additional, Rea, Federico, additional, Fattori, Antonin, additional, Chenard, Marie-Pierrette, additional, Ohana, Mickael, additional, Labani, Aissam, additional, Kessler, Romain, additional, and Hirschi, Sandrine, additional

Published
2019
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435. Predictors of behaviour in solitary fibrous tumours of the pleura surgically resected: Analysis of 107 patients

Author

Bellini, Alice, primary, Marulli, Giuseppe, additional, Breda, Cristiano, additional, Ferrigno, Pia, additional, Terzi, Stefano, additional, Lomangino, Ivan, additional, Lo Giudice, Fabio, additional, Brombin, Claudia, additional, Laurino, Licia, additional, Pezzuto, Federica, additional, Calabrese, Fiorella, additional, and Rea, Federico, additional

Published
2019
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438. Surgical Decision Making

Author

Comacchio, Giovanni M., primary, Marulli, Giuseppe, additional, Mammana, Marco, additional, Natale, Giuseppe, additional, Schiavon, Marco, additional, and Rea, Federico, additional

Published
2019
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440. High-Resolution Computed Tomography (HRCT) Reflects Disease Progression in Patients with Idiopathic Pulmonary Fibrosis (IPF): Relationship with Lung Pathology

Author

Cocconcelli, Elisabetta, primary, Balestro, Elisabetta, additional, Biondini, Davide, additional, Barbiero, Giulio, additional, Polverosi, Roberta, additional, Calabrese, Fiorella, additional, Pezzuto, Federica, additional, Lacedonia, Donato, additional, Rea, Federico, additional, Schiavon, Marco, additional, Bazzan, Erica, additional, Foschino Barbaro, Maria, additional, Turato, Graziella, additional, Spagnolo, Paolo, additional, Cosio, Manuel, additional, and Saetta, Marina, additional

Published
2019
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444. Vein Suturing Results in Worse Lung Graft Outcomes Compared to the Cuff Method

Author

Zampieri, Davide, primary, Azzollini, Nadia, additional, Vuljan, Stefania, additional, Pezzuto, Federica, additional, Fiori, Sonia, additional, Mister, Marilena, additional, Todeschini, Marta, additional, Rodriguez Ordonez, Pamela Yossenaidy, additional, Marulli, Giuseppe, additional, Rea, Federico, additional, Calabrese, Fiorella, additional, and Casiraghi, Federica, additional

Published
2019
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446. Pushing the limits of reconditioning: extended normothermic lung perfusion in an extended criteria donor

Author

Schiavon, Marco, primary, Zampieri, Davide, additional, Marulli, Giuseppe, additional, Verderi, Enrico, additional, Rebusso, Alessandro, additional, Comacchio, Giovanni Maria, additional, Nicotra, Samuele, additional, Loy, Monica, additional, Lunardi, Francesca, additional, Feltracco, Paolo, additional, Calabrese, Fiorella, additional, Cozzi, Emanuele, additional, and Rea, Federico, additional

Published
2018
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447. Best practices for the management of thymic epithelial tumors: A position paper by the Italian collaborative group for ThYmic MalignanciEs (TYME)

Author

Imbimbo, Martina, primary, Ottaviano, Margaret, additional, Vitali, Milena, additional, Fabbri, Alessandra, additional, Leuzzi, Giovanni, additional, Fiore, Michele, additional, Franceschini, Davide, additional, Pasello, Giulia, additional, Perrino, Matteo, additional, Schiavon, Marco, additional, Pruneri, Giancarlo, additional, Dei Tos, Angelo Paolo, additional, Sangalli, Claudia, additional, Garassino, Marina Chiara, additional, Berardi, Rossana, additional, Alessi, Alessandra, additional, Calareso, Giuseppina, additional, Petrini, Iacopo, additional, Scorsetti, Marta, additional, Scotti, Vieri, additional, Rosso, Lorenzo, additional, Rea, Federico, additional, Pastorino, Ugo, additional, Casali, Paolo Giovanni, additional, Ramella, Sara, additional, Ricardi, Umberto, additional, Abate-Daga, Laura, additional, Torri, Valter, additional, Trama, Annalisa, additional, Palmieri, Giovannella, additional, Marino, Mirella, additional, Zucali, Paolo Andrea, additional, Alloisio, Marco, additional, Apolone, Giovanni, additional, Ardizzoni, Andrea, additional, Benvenuti, Mauro, additional, Berruti, Alfredo, additional, Breda, Cristiano, additional, Buzzoni, Carlotta, additional, Calabrese, Fiorella, additional, Caraceni, Augusto, additional, Cardillo, Giuseppe, additional, Casadio, Caterina, additional, Cassi, Elio, additional, Caterino, Mauro, additional, Cecere, Fabiana Letizia, additional, Chiti, Arturo, additional, Crippa, Arturo, additional, Curcio, Carlo, additional, De Braud, Filippo, additional, De Pas, Tommaso, additional, Di Tommaso, Luca, additional, Evoli, Amelia, additional, Facciolo, Francesco, additional, Galli, Giulia, additional, Lopez, Ignazio, additional, Lo Russo, Giuseppe, additional, Luisella, Spinelli, additional, Luzzi, Luca, additional, Mantovani, Cristina, additional, Marchianò, Alfonso, additional, Margaritora, Stefano, additional, Monaco, Roberto, additional, Morandi, Uliano, additional, Novellino, Lorenzo, additional, Piras, Maria Teresa, additional, Porcu, Luca, additional, Priola, Adriano, additional, Proto, Claudia, additional, Battista Ratto, Giovanni, additional, Rena, Ottavio, additional, Rinaldi, Silvia, additional, Roca, Elisa, additional, Rocco, Gaetano, additional, Ruffini, Enrico, additional, Signorelli, Diego, additional, Solli, Piergiorgio, additional, Spaggiari, Lorenzo, additional, Stefani, Alessandro, additional, Veltri, Andrea, additional, Vespro, Valentina, additional, and Zilembo, Nicoletta, additional

Published
2018
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448. Current Practices in the Management of Pulmonary Ground-Glass Opacities: A Survey of SICT Members

Author

Lococo, Filippo, primary, Cusumano, Giacomo, additional, De Filippis, Antonio Fabillian, additional, Curcurù, Giuseppe, additional, Quercia, Rosatea, additional, Marulli, Giuseppe, additional, Monaco, Guglielmo, additional, Granone, Pierluigi, additional, Muriana, Giovanni, additional, Rea, Federico, additional, Crisci, Roberto, additional, Di Rienzo, Gaetano, additional, Cardillo, Giuseppe, additional, Lococo, Achille, additional, Lococo, Filippo, additional, Amore, Dario, additional, Divisi, Duilio, additional, Dolci, Giampiero, additional, Guggino, Gianluca, additional, Larocca, Valentina, additional, Loizzi, Domenico, additional, Luzzi, Luca, additional, Monaco, Francesco, additional, Porziella, Venanzio, additional, and Rena, Ottavio, additional

Published
2018
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449. Pathologic Grading of Malignant Pleural Mesothelioma: An Evidence-Based Proposal

Author

Pelosi, Giuseppe, primary, Papotti, Mauro, additional, Righi, Luisella, additional, Rossi, Giulio, additional, Ferrero, Stefano, additional, Bosari, Silvano, additional, Calabrese, Fiorella, additional, Kern, Izidor, additional, Maisonneuve, Patrick, additional, Sonzogni, Angelica, additional, Albini, Adriana, additional, Harari, Sergio, additional, Barbieri, Fausto, additional, Capelletto, Enrica, additional, Catino, Anna Maria, additional, Cavone, Domenica, additional, De Palma, Angela, additional, Fusco, Nicola, additional, Lunardi, Francesca, additional, Maiorano, Eugenio, additional, Marzullo, Andrea, additional, Novello, Silvia, additional, Papanikolaou, Nikolaos, additional, Pasello, Giulia, additional, Pennella, Antonio, additional, Pezzuto, Federica, additional, Punzi, Alessandra, additional, Prisciandaro, Elena, additional, Rea, Federico, additional, Rosso, Lorenzo, additional, Scattone, Anna, additional, and Serio, Gabriella, additional

Published
2018
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450. The IASLC Mesothelioma Staging Project: Proposals for Revisions of the N Descriptors in the Forthcoming Eighth Edition of the TNM Classification for Pleural Mesothelioma

Author

Rice, David, Chansky, Kari, Nowak, Anna, Pass, Harvey, Kindler, Hedy, Shemanski, Lynn, Opitz, Isabelle, Caja, Sergi Call, Hasegawa, Seiki, Kernstine, Kemp, Atinkaya, Cansel, Rea, Federico, Nafteux, Philippe, Rusch, Valerie, Goldstraw, Peter, Rami-Porta, Ramón, Asamura, Hisao, Ball, David, Beer, David, Beyruti, Ricardo, Bolejack, Vanessa, Chansky, Kari, Crowley, John, Detterbeck, Frank, Eberhardt, Wilfried Ernst Erich, Edwards, John, Galateau-Sallé, Françoise, Giroux, Dorothy, Gleeson, Fergus, Groome, Patti, Huang, James, Kennedy, Catherine, Kim, Jhingook, Kim, Young Tae, Kingsbury, Laura, Kondo, Haruhiko, Krasnik, Mark, Kubota, Kaoru, Lerut, Antoon, Lyons, Gustavo, Marino, Mirella, Marom, Edith M., van Meerbeeck, Jan, Mitchell, Alan, Nakano, Takashi, Nicholson, Andrew G., Nowak, Anna, Peake, Michael, Rice, Thomas, Rosenzweig, Kenneth, Ruffini, Enrico, Rusch, Valerie, Saijo, Nagahiro, Van Schil, Paul, Sculier, Jean-Paul, Shemanski, Lynn, Stratton, Kelly, Suzuki, Kenji, Tachimori, Yuji, Thomas, Charles F., Travis, William, Tsao, Ming S., Turrisi, Andrew, Vansteenkiste, Johan, Watanabe, Hirokazu, Wu, Yi-Long, Baas, Paul, Erasmus, Jeremy, Hasegawa, Seiki, Inai, Kouki, Kernstine, Kemp, Kindler, Hedy, Krug, Lee, Nackaerts, Kristiaan, Pass, Harvey, Rice, David, Falkson, Conrad, Filosso, Pier Luigi, Giaccone, Giuseppe, Kondo, Kazuya, Lucchi, Marco, Okumura, Meinoshin, Blackstone, Eugene, Asamura, Hisao, Batirel, Hasan, Bille, Andrea, Pastorino, Ugo, Caja, Sergi Call, Cangir, Ayten K., Cedres, Susana, Friedberg, Joseph S., Galateau-Salle, Francoise, Hasagawa, Seiki, Kernstine, Kemp H., Kindler, Hedy, McCaughan, Brian, Nafteux, Philippe, Nakano, Takashi, Nowak, Anna, Ozturk, Cansel Atinkaya, Pass, Harvey, de Perrot, Marc, Rea, Federico, Rice, David C., Rintoul, Robert, Ruffini, Enrico, Rusch, Valerie, Spaggiari, Lorenzo, Galetta, Domenico, Syrigos, K.N., Thomas, Charles, van Meerbeeck, Jan, Weder, Walter, Opitz, Isabelle, and Yoshimura, Masahiro

Abstract

Nodal categories for malignant pleural mesothelioma are derived from the lung cancer staging system and have not been adequately validated. The International Association for the Study of Lung Cancer developed a multinational database to generate evidence-based recommendations to inform the eighth edition of the TNM classification of malignant pleural mesothelioma.

Published
2024
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