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403. Correction: A disease-specific patient reported outcome instrument for spine trauma is developed, validated and available! Re: Andrzejowski et al. Measuring functional outcomes in major trauma: can we do better?

Author

Sadiqi, Said and Oner, F. Cumhur

Subjects
HEALTH outcome assessment, FUNCTIONAL assessment, PATIENTS' attitudes, SPINAL injuries, OCCUPATIONAL adaptation
Abstract

A correction is presented to the article "A disease-specific patient reported outcome instrument for spine trauma is developed, validated and available! Re: Andrzejowski et al. Measuring functional outcomes in major trauma: can we do better?" which appeared in the November 15, 2022 issue.

Published
2023
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404. Effect of silicone oil removal on central corneal thickness

Author

DURAK, İSMET, Oner, F. Hakan, ARIKAN, GÜL, ÖZBEK, ZEYNEP, and SAATCİ, ALİ OSMAN

Subjects
Clinical Research
Abstract

To evaluate the effect of silicone oil removal(SOR) on central corneal thickness(CCT) in aphakic and pseudophakic eyes prospectively.Patients who underwent SOR surgery between June 2005 - August 2007 were included in this study. Silicon oil was actively removed behind the posterior capsule through the pars plana sclerotomy site (posterior approach) in pseudophakic eyes and through the pupil and the corneal tunnel incision (anterior approach) in aphakic eyes with the 18-gauge cannula. CCT was assessed with Orbscan II corneal topography system preoperatively and at one month and three months postoperatively. A total of 34 eyes of 34 patients (26 males, 8 females) comprised the study group. Mean age was (55.6±12.3) years (Range: 25-80 years). Twenty-six eyes (76.5%) were pseudophakic and 8 (23.5%) aphakic. Mean time between silicone oil injection and removal was (15.1±13.6) months (Range: 5-54 months). At baseline, CCT was 576.4±46.0µm in pseudophakic eyes and 611.6±36.2µm in aphakic eyes.At the first postoperative month CCT was (573.3±40.1)µm and (630.9±72.9)µm in pseudophakic and aphakic eyes respectively. At the third postoperative month, CCT was (582.7±49.5)µm and (614.5±82.4)µm in pseudophakic and aphakic eyes respectively. There was no statistically significant difference in CCT measurements one month and 3 months after SOR when compared to preoperative values in both aphakic and pseudophakic eyes (P0.05).Active SOR either by anterior or posterior approach did not affect the CCT.

Published
2012

405. Asthma in elderly in Turkey: a multicenter study

Author

Gemicioglu, B., Mungan, D., Ogus, C., Erkekol, Oner F., Dursun, B., Saka, D., Yorgancioglu, A., and Zonguldak Bülent Ecevit Üniversitesi

Subjects
education, parasitic diseases, social sciences, health care economics and organizations
Abstract

31st Congress of the European-Academy-of-Allergy-and-Clinical-Immunology (EAACI) -- JUN 16-20, 2012 -- Geneva, SWITZERLAND, WOS: 000310247703449, European Acad Allergy & Clin Immunol (EAACI)

Published
2012

406. CROSS-Sectional Assessment of Damage in Takayasu Arteritis with A Validated Tool

Author

Omma, A., Erer, B., Karadag, O., Yilmaz, N., Oner, F. Alibaz, Yildiz, F., Kiraz, S., and Çukurova Üniversitesi

Abstract

Annual Scientific Meeting of the American-College-of-Rheumatology (ACR) and Association-of-Rheumatology-Health-Professionals (ARHP) -- NOV 09-14, 2012 -- Washington, DC WOS: 000309748305284 … Amer Coll Rheumatol (ACR), Assoc Rheumatol Hlth Profess (ARHP)

Published
2012

407. Complications, secondary interventions and long term morbidity after en bloc sacrectomy.

Author

Verlaan, J., Kuperus, J., Slooff, W., Hennipman, A., Oner, F., Verlaan, J J, Kuperus, J S, Slooff, W B, and Oner, F C

Subjects
SACRUM, CANCER diagnosis, CANCER patients, CANCER relapse, COMBINED modality therapy, HEMORRHAGE, LENGTH of stay in hospitals, LIFE skills, METASTASIS, ORTHOPEDIC implants, PATIENTS, POSTOPERATIVE period, RADIOTHERAPY, SURGERY, SURGICAL complications, PLASTIC surgery, SURGICAL site infections, SURVIVAL analysis (Biometry), THERAPEUTIC complications, URINARY tract infections, WOUND care, SPINAL tumors, TREATMENT effectiveness, PATIENT readmissions, PERIOPERATIVE care
Abstract

Purpose: En bloc sacrectomy is a demanding surgical procedure to remove tumors from the sacrum. Comprehensive data on readmissions for complications endured months to years after initial discharge are scant. The purpose of this study is to present the long-term complications, readmissions and secondary interventions for patients having undergone en bloc sacrectomy.Methods: Patients were included if en bloc sacrectomy and follow-up were conducted in the authors institution. Correspondence from all specialties involved in the treatment of patients was retrieved. Predefined parameters were scored and assigned to five distinct phases: diagnostic phase; surgery; postoperative period to 1 year after surgery; second year after surgery until follow-up and last follow-up.Results: Sixteen patients underwent anterior-posterior en bloc sacrectomy for a locally aggressive tumor (n=2); malignant tumor (n=13) or solitary metastasis (n=1). The type of resection was low (n=1); middle (n=3); high (n=4); total (n=3) and hemisacrectomy (n=5). The median surgical duration was 12.7 h and median blood lost was 12 l. A total of 73 major complications (average per patient 5; median 4; range 0-12) were recorded and 73 secondary interventions (average per patient 5; median 5; range 0-11) were performed in the first year postsurgery. From the second year until follow-up complications and secondary interventions markedly decreased. At final follow-up (65-266 months), considerable morbidity was found for the eleven patients still alive.Conclusions: En bloc sacrectomy is a procedure with a high rate of major complications, regardless of tumor histology, often necessitating readmissions and secondary interventions. Long-term survival is associated with considerable morbidity and extensive preoperative counseling should be conducted to discuss the risks and outcome of the procedure. [ABSTRACT FROM AUTHOR]

Published
2015
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408. Diffuse idiopathic skeletal hyperostosis of the cervical spine: an underestimated cause of dysphagia and airway obstruction

Author

Verlaan, Jorrit-Jan, Boswijk, Petronella F E, de Ru, Jacob A, Dhert, Wouter J A, Oner, F Cumhur, Onderzoek, and Onderzoek

Subjects
medicine.medical_specialty, Hyperostosis, Context (language use), Review, medicine, Journal Article, Humans, Orthopedics and Sports Medicine, Esophagus, Diffuse Idiopathic Skeletal Hyperostosis, Hyperostosis, Diffuse Idiopathic Skeletal, business.industry, Airway obstruction, medicine.disease, Dysphagia, Surgery, Airway Obstruction, Diffuse Idiopathic Skeletal, medicine.anatomical_structure, Diffuse idiopathic skeletal hyperostosis (DISH), Cervical Vertebrae, Neurology (clinical), Differential diagnosis, medicine.symptom, business, Deglutition Disorders
Abstract

Background context Diffuse idiopathic skeletal hyperostosis (DISH) is a common but underdiagnosed condition relating to ossification of spinal ligaments that can cause compression of the esophagus and trachea. According to case reports, dysphagia or airway obstruction resulting from DISH is a rare occurrence. Purpose This study was intended to identify all published cases of dysphagia and/or airway obstruction resulting from DISH to increase the epidemiologic/clinical knowledge of these related conditions. Study design A systematic review of the literature was performed. Methods The articles resulting from the systematic PubMed/EMBASE search of the literature were closely read, and predefined parameters were scored. Results The search yielded a total of 118 articles (95 case reports and 23 case series) describing 204 patients with dysphagia and/or airway obstruction resulting from DISH. The number of cases demonstrated a steady increase from 1980 to 2009. This might be a real effect not ascribable to publication bias or expansion of the medical literature alone. Conclusions Diffuse idiopathic skeletal hyperostosis as a cause of dysphagia and/or airway obstruction may be an increasing and underappreciated phenomenon. Diffuse idiopathic skeletal hyperostosis should be included in the differential diagnosis of dysphagia and airway obstruction.

Published
2011

409. The Thoracolumbar AOSpine Injury Score

Author

Kepler, Christopher K., primary, Vaccaro, Alexander R., additional, Schroeder, Gregory D., additional, Koerner, John D., additional, Vialle, Luiz R., additional, Aarabi, Bizhan, additional, Rajasekaran, Shanmuganathan, additional, Bellabarba, Carlo, additional, Chapman, Jens R., additional, Kandziora, Frank, additional, Schnake, Klaus J., additional, Dvorak, Marcel F., additional, Reinhold, Max, additional, and Oner, F. Cumhur, additional

Published
2015
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410. Toward Developing a Specific Outcome Instrument for Spine Trauma

Author

Oner, F. Cumhur, primary, Sadiqi, Said, additional, Lehr, A. Mechteld, additional, Aarabi, Bizhan, additional, Dunn, Robert N., additional, Dvorak, Marcel F., additional, Fehlings, Michael G., additional, Kandziora, Frank, additional, Post, Marcel W., additional, Rajasekaran, S., additional, Vialle, Luiz, additional, and Vaccaro, Alexander R., additional

Published
2015
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419. FRI0265 Validation of New 2012 EULAR/ACR Clinical Classification Criteria for Polymyalgia Rheumatica: Comparison with the Previous Criteria in a Prospective Multi-Center Study

Author

Ozen, G., primary, Bas, S., additional, Unal, A.U., additional, Kimyon, G., additional, Onat, A.M., additional, Murat, S., additional, Keskin, H., additional, Sahin, A., additional, Can, M., additional, Mengi, A., additional, Yilmaz, S., additional, Balkarli, A., additional, Cobankara, V., additional, Pamuk, O.N., additional, Cagatay, Y., additional, Bayindir, O., additional, Aksu, K., additional, Alibaz-Oner, F., additional, Gok, K., additional, Senel, S., additional, Yilmaz, N., additional, Yildirim-Cetin, G., additional, Akyol, L., additional, Sayarlioglu, M., additional, Yagci, I., additional, Atagunduz, P., additional, Aydin, S.Z., additional, Inanc, N., additional, and Direskeneli, H., additional

Published
2015
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420. The surgical algorithm for the AOSpine thoracolumbar spine injury classification system

Author

Vaccaro, Alexander R., primary, Schroeder, Gregory D., additional, Kepler, Christopher K., additional, Cumhur Oner, F., additional, Vialle, Luiz R., additional, Kandziora, Frank, additional, Koerner, John D., additional, Kurd, Mark F., additional, Reinhold, Max, additional, Schnake, Klaus J., additional, Chapman, Jens, additional, Aarabi, Bizhan, additional, Fehlings, Michael G., additional, and Dvorak, Marcel F., additional

Published
2015
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422. Establishing the Injury Severity of Thoracolumbar Trauma

Author

Schroeder, Gregory D., primary, Vaccaro, Alexander R., additional, Kepler, Christopher K., additional, Koerner, John D., additional, Oner, F. Cumhur, additional, Dvorak, Marcel F., additional, Vialle, Luiz R., additional, Aarabi, Bizhan, additional, Bellabarba, Carlo, additional, Fehlings, Michael G., additional, Schnake, Klaus J., additional, and Kandziora, Frank, additional

Published
2015
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424. A Worldwide Analysis of the Reliability and Perceived Importance of an Injury to the Posterior Ligamentous Complex in AO Type a Fractures

Author

Schroeder, Gregory D., primary, Kepler, Christopher K., additional, Koerner, John D., additional, Oner, F. Cumhur, additional, Fehlings, Michael G., additional, Aarabi, Bizhan, additional, Dvorak, Marcel F., additional, Reinhold, Max, additional, Kandziora, Frank, additional, Bellabarba, Carlo, additional, Chapman, Jens R., additional, Vialle, Luiz R., additional, and Vaccaro, Alexander R., additional

Published
2015
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425. Can a Thoracolumbar Injury Severity Score be Uniformly Applied from T1 to L5 or Are Modifications Necessary?

Author

Schroeder, Gregory D., primary, Kepler, Christopher K., additional, Koerner, John D., additional, Oner, F. Cumhur, additional, Fehlings, Michael G., additional, Aarabi, Bizhan, additional, Schnake, Klaus J., additional, Rajasekaran, Shanmuganathan, additional, Kandziora, Frank, additional, Vialle, Luiz R., additional, and Vaccaro, Alexander R., additional

Published
2015
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426. AOSpine subaxial cervical spine injury classification system

Author

Vaccaro, Alexander R., primary, Koerner, John D., additional, Radcliff, Kris E., additional, Oner, F. Cumhur, additional, Reinhold, Maximilian, additional, Schnake, Klaus J., additional, Kandziora, Frank, additional, Fehlings, Michael G., additional, Dvorak, Marcel F., additional, Aarabi, Bizhan, additional, Rajasekaran, Shanmuganathan, additional, Schroeder, Gregory D., additional, Kepler, Christopher K., additional, and Vialle, Luiz R., additional

Published
2015
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427. Towards the Development of an Outcome Instrument for Spinal Trauma

Author

Oner, F. Cumhur, primary, Sadiqi, Said, additional, Lehr, A. Mechteld, additional, Dvorak, Marcel F., additional, Aarabi, Bizhan, additional, Chapman, Jens R., additional, Fehlings, Michael G., additional, Kandziora, Frank, additional, Rajasekaran, S., additional, and Vaccaro, Alexander R., additional

Published
2015
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428. Cell type and transfection reagent-dependent effects on viability, cell content, cell cycle and inflammation of RNAi in human primary mesenchymal cells

Author

Yang, Hsiao-yin, Vonk, Lucienne A., Licht, Ruud, van Boxtel, Antonetta M. G., Bekkers, Joris E. J., Kragten, Angela H. M., Hein, San, Varghese, Oommen P., Howard, Kenneth A., Oner, F. Cumhur, Dhert, Wouter J. A., Creemers, Laura B., Yang, Hsiao-yin, Vonk, Lucienne A., Licht, Ruud, van Boxtel, Antonetta M. G., Bekkers, Joris E. J., Kragten, Angela H. M., Hein, San, Varghese, Oommen P., Howard, Kenneth A., Oner, F. Cumhur, Dhert, Wouter J. A., and Creemers, Laura B.

Abstract

The application of RNA interference (RNAi) has great therapeutic potential for degenerative diseases of cartilaginous tissues by means of fine tuning the phenotype of cells used for regeneration. However, possible non-specific effects of transfection per se might be relevant for future clinical application. In the current study, we selected two synthetic transfection reagents, a cationic lipid-based commercial reagent Lipofectamine RNAiMAX and polyethylenimine (PEI), and two naturally-derived transfection reagents, namely the polysaccharides chitosan (98% deacetylation) and hyaluronic acid (20% amidation), for siRNA delivery into primary mesenchymal cells including nucleus pulposus cells, articular chondrocytes and mesenchymal stem cells (MSCs). Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was used as an endogenous model gene to evaluate the extent of silencing by 20 nM or 200 nM siRNA at day 3 and day 6 post-transfection. In addition to silencing efficiency, non-specific effects such as cytotoxicity, change in DNA content and differentiation potential of cells were evaluated. Among the four transfection reagents, the commercial liposome-based agent was the most efficient reagent for siRNA delivery at 20 nM siRNA, followed by chitosan. Transfection using cationic liposomes, chitosan and PEI showed some decrease in viability and DNA content to varying degrees that was dependent on the siRNA dose and cell type evaluated, but independent of GAPDH knockdown. Some effects on DNA content were not accompanied by concomitant changes in viability. However, changes in expression of marker genes for cell cycle inhibition or progression, such as p21 and PCNA, could not explain the changes in DNA content. Interestingly, aspecific upregulation of GAPDH activity was found, which was limited to cartilaginous cells. In conclusion, non-specific effects should not be overlooked in the application of RNAi for mesenchymal cell transfection and may need to be overcome for its effecti

Published
2014
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429. Stromal cell-derived factor-1 stimulates cell recruitment, vascularization and osteogenic differentiation

Author

Faculteit Diergeneeskunde, LS Equine Muscoskeletal Biology, Onderzoek, CSCA TR1, Tissue Repair, Eman, Rhandy M, Oner, F Cumhur, Kruyt, Moyo C, Dhert, Wouter J A, Alblas, Jacqueline, Faculteit Diergeneeskunde, LS Equine Muscoskeletal Biology, Onderzoek, CSCA TR1, Tissue Repair, Eman, Rhandy M, Oner, F Cumhur, Kruyt, Moyo C, Dhert, Wouter J A, and Alblas, Jacqueline

Published
2014

430. Prolonged presence of VEGF promotes vascularization in 3D bioprinted scaffolds with defined architecture

Author

Faculteit Diergeneeskunde, LS Equine Muscoskeletal Biology, Onderzoek, CSCA TR1, Tissue Repair, Poldervaart, Michelle T, Gremmels, Hendrik, van Deventer, Kelly, Fledderus, Joost O, Oner, F Cumhur, Verhaar, Marianne C, Dhert, Wouter J A, Alblas, Jacqueline, Faculteit Diergeneeskunde, LS Equine Muscoskeletal Biology, Onderzoek, CSCA TR1, Tissue Repair, Poldervaart, Michelle T, Gremmels, Hendrik, van Deventer, Kelly, Fledderus, Joost O, Oner, F Cumhur, Verhaar, Marianne C, Dhert, Wouter J A, and Alblas, Jacqueline

Published
2014

431. Ethical implications of regenerative medicine in orthopedics: an empirical study with surgeons and scientists in the field

Author

Faculteit Diergeneeskunde, LS Equine Muscoskeletal Biology, Onderzoek, Tissue Repair, CSCA TR1, Niemansburg, Sophie L, van Delden, Johannes J M, Oner, F Cumhur, Dhert, Wouter J A, Bredenoord, Annelien L, Faculteit Diergeneeskunde, LS Equine Muscoskeletal Biology, Onderzoek, Tissue Repair, CSCA TR1, Niemansburg, Sophie L, van Delden, Johannes J M, Oner, F Cumhur, Dhert, Wouter J A, and Bredenoord, Annelien L

Published
2014

432. CXCL12/Stromal-Cell-Derived Factor-1 Effectively Replaces Endothelial Progenitor Cells to Induce Vascularized Ectopic Bone

Author

Faculteit Diergeneeskunde, LS Equine Muscoskeletal Biology, Onderzoek, CSCA TR1, Tissue Repair, Eman, Rhandy M, Hoorntje, Edgar T, Oner, F Cumhur, Kruyt, Moyo C, Dhert, Wouter J A, Alblas, Jacqueline, Faculteit Diergeneeskunde, LS Equine Muscoskeletal Biology, Onderzoek, CSCA TR1, Tissue Repair, Eman, Rhandy M, Hoorntje, Edgar T, Oner, F Cumhur, Kruyt, Moyo C, Dhert, Wouter J A, and Alblas, Jacqueline

Published
2014

433. Applicability of a Newly Developed Bioassay for Determining Bioactivity of Anti-Inflammatory Compounds in Release Studies - Celecoxib and Triamcinolone Acetonide Released from Novel PLGA-Based Microspheres

Author

Tissue Repair, ES TR, Faculteit Diergeneeskunde, LS Equine Muscoskeletal Biology, Onderzoek, Yang, Hsiao-Yin, van Dijk, Maarten, Licht, Ruud, Beekhuizen, Michiel, van Rijen, Mattie, Janstål, Martina Källrot, Oner, F Cumhur, Dhert, Wouter J A, Schumann, Detlef, Creemers, Laura B, Tissue Repair, ES TR, Faculteit Diergeneeskunde, LS Equine Muscoskeletal Biology, Onderzoek, Yang, Hsiao-Yin, van Dijk, Maarten, Licht, Ruud, Beekhuizen, Michiel, van Rijen, Mattie, Janstål, Martina Källrot, Oner, F Cumhur, Dhert, Wouter J A, Schumann, Detlef, and Creemers, Laura B

Published
2014

437. Activation of the JAK/STAT pathway in Behcet’s disease

Author

Tulunay, A, primary, Dozmorov, M G, additional, Ture-Ozdemir, F, additional, Yilmaz, V, additional, Eksioglu-Demiralp, E, additional, Alibaz-Oner, F, additional, Ozen, G, additional, Wren, J D, additional, Saruhan-Direskeneli, G, additional, Sawalha, A H, additional, and Direskeneli, H, additional

Published
2014
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438. HbA1c Awareness in Turkish Diabetic Population at a Tertiary Setting

Author

Karahan, Eyyuep, Oner, F. Hakan, SAATCİ, ALİ OSMAN, and Ozkara, Elvan

Abstract

Objective: To assess the HbA1c awareness among Turkish diabetic patients examined at a tertiary eye center located in Izmir, Turkey. Material and Methods: A prospective, non-randomized study was carried out involving 750 consecutive diabetic patients examined at the Retina Unit of Dokuz Eylul University Ophthalmology Department. An oral questionnaire on HbA1c awareness and patients' general characteristics was read to the patients. Retinopathy status was evaluated by indirect ophthalmoscopy and contact lens biomicroscopy. HbA1c awareness was analyzed according to age, type and duration of diabetes, referral pattern, education level, diabetes care, severity of diabetic retinopathy and treatment type. Results: Overall, 109 of 750 patients (14.5%) acknowledged the importance of HbA1c. Statistically, patients under 40 years of age, type I diabetics, patients on insulin therapy, patients under supervision of an endocrinology department, patients with a higher education level and patients with no retinopathy had a higher level of awareness for HbA1c. Conclusion: Our study reflects that better strategies are necessary in Turkish diabetic patients to improve self-management in diabetes.

Published
2009

439. Measurements of Radon Concentrations in Spa Waters in Amasya, Turkey.

Author

Yigitoglu, I., Oner, F., Yalim, H. A., and Ucar, B.

Subjects
*RADON, *GEOTHERMAL resources, *GEOLOGIC faults, *EARTHQUAKES
Abstract

The aim of this study is to determine the radon concentrations in thermal waters in the Amasya basin in Turkey and to explore the relationship between radon anomalies and active geological faults. The radon concentration measurements were performed in four thermal Spas around Amasya basin. The water samples were collected from tap waters in thermal water sources. The obtained radon concentrations ranged from 0.15 ± 0.12 to 0.71 ± 0.32 Bql-1 for Spa waters. The relationship between the radon concentration anomalies and earthquakes that occurred in the sampling period are discussed. [ABSTRACT FROM AUTHOR]

Published
2016
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447. OP0234 Effects of Anticoagulant Treatment on the Incidence of New Vascular Events in Patients with Behcet's Disease with Vascular Involvement

Author

Alibaz-Oner, F., primary, Karadeniz, A., additional, Yilmaz, S., additional, Balkarlı, A., additional, Cobankara, V., additional, Yazıcı, A., additional, Cefle, A., additional, Kimyon, G., additional, Kisacik, B., additional, Onat, A.M., additional, Yildiz, F., additional, Erken, E., additional, Bilge, S.Y., additional, Kasifoglu, T., additional, Yildirim Cetin, G., additional, Sayarlıoglu, M., additional, and Direskeneli, H., additional

Published
2014
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448. Geochemistry of fluorite occurrence from Feke (Adana-Turkey) in the East Taurid Mountains

Author

Uras, Y, Oner, F, Yaman, S, and Çukurova Üniversitesi

Subjects
fluorite deposit, fluorite, REE, diagenesis
Abstract

WOS: 000183262100003 A fluorite mineralization is observed within the sediment rock, having dimensions of about 60 m in length and between 0.4-2 m in thickness is found in the Feke (Adana) region. In this study, it is aimed to explain the genesis of this deposit by means of rare element geochemistry analyses. The fluorite samples analysed showed low REE-contents (REE < 10 ppm) on the average which are characteristics for Fluorite sedimental-diagenetic origin. The carbonate host-rocks are about ten times richer on REE. The REE-distribution pattern of fluorite and host-rocks are marked through strong enrichments and negative slopes. The Cc and Eu anomalities indicates an oxidative conditions by the fluorite-precipitate. In the Tb/Ca and Tb/La diagram all the fluorite samples lie in the sedimentary field. All the data indicate that, fluorite-deposits occured during diagenetic events which caused the intraformational formation water migration in the carbonate sedimentary environment as well as its alteration effect with surface-solutions.

Published
2003

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