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Field experiments were conducted during 1998–99 and 1999–2000 at research farm of the Department of Agricultural Meteorology, CCS Haryana Agricultural University, Hisar. Five wheat cultivars: WH 542, PBW 343, UP 2338, Raj 3765 and Sonak were sown on 25th November, 10th and 25th December with four nitrogen levels viz., no nitrogen. 50, 100 and 150% of recommended dose. Leaf area index, dry matter at anthesis, final dry biomass and grain yield were recorded in all the treatments. Chlorophyll and wax contents of wheat leaves were estimated at different growth stages. Multiband spectral reflectance was measured using hand-held radiometer. Spectral indices such as simple ratio, normalized difference, transformed vegetation index, perpendicular vegetation index and greenness index were computed using the multiband spectral data. Values of all the spectral indices were maximum in 25 November sown crop with maximum dose of nitrogen (180 kg N ha-1). PBW 343 showed higher values of all the spectral indices in comparison with other cultivars. The spectral indices recorded during maximum leaf area index stage were correlated with crop parameters. Using stepwise regression, empirical models for chlorophyll, leaf area index, dry biomass and yield prediction were developed. The ’R2’ values of these models ranged between 0.87 and 0.95. [ABSTRACT FROM AUTHOR]

A case of dystocia in a mare with longitudinal presentation, dorso-sacral position with lateral deviation of head and bilateral knee flexion was presented in Veterinary Clinical Complex of the university and was resolved by caesarean section under gaseous anaesthesia. [ABSTRACT FROM AUTHOR]

A mule was presented with gradually increasing swelling on left lateral abdomen since six months. Clinical and ultrasonographic examination revealed defect in abdominal wall forming a hernial ring with irreducible contents mainly intestines. Under inhalant anaesthesia, hernioplasty was performed using polypropylene mesh and animal recovered uneventfully. [ABSTRACT FROM AUTHOR]

Background: The increasing impacts of heat stress on wheat production due to climate change has entailed the development of heat-resilient crop varieties. To address this, two hundred recombinant inbred lines (RILs) derived from a cross between WH711/WH1021 were evaluated in a randomized block design (RBD) with two replications at CCSHAU, Hisar, during 2018-19 under heat stress and non-stress conditions. Heat stress was induced by altering the date of sowing so that the grain filling stage coincide with heat stress. Results: Heat stress adversely affects RILs performance, as illustrated by alterations in phenotypic traits. Highest coefficients of variations were recorded for TAA, CTD 1, WUE, CTD 2, Cc and A under non-stress and heat stress conditions whereas gs, WUEi and GY under non-stress and SPAD 1, SPAD 2, GY and NDVI 2 under heat-stress conditions recorded moderate estimates of coefficient of variations. CTD 2, TAA, E, WUE and A displayed a significant occurrence of both high heritability and substantial genetic advance under non-stress. Similarly, CTD 2, NDVI 2, A, WUEi, SPAD 2, gs, E, Ci, MDA and WUE exhibited high heritability with high genetic advance under heat-stress conditions. Conclusions: Complementary and duplicate types of interactions with number of controlling genes were observed for different parameters depending on the traits and environments. RILs 41, 42, 59, 74, 75, 180 and 194 were categorized as heat tolerant RILs. Selection preferably for NDVI 1, RWC, TAA, A, E and WUEi to accumulate heat tolerance favorable alleles in the selected RILs is suggested for development of heat resilient genotypes for sustainable crop improvement. The results showed that traits such as such as NDVI, RWC, TAA, A, E, and WUEi, can be effective for developing heat-resilient wheat genotypes and ensuring sustainable crop improvement. [ABSTRACT FROM AUTHOR]

An investigation was conducted in randomized block design under timely and late sown conditions using two hundred recombinant inbred lines from a cross between WH711 and WH1021 cultivars. The heat stress conditions have detrimental effects on the performance of recombinant inbred lines (RILs), as depicted by alterations in different phenotypic traits. The grain filling duration, number of effective tillers per meter, grain yield/plot and biological yield/plot traits under non-stress conditions and number of effective tillers per meter, biological yield/plot, number of grains/spike, and 100 grain volume traits under heat stress conditions recorded moderate estimates of coefficient of variations. High heritability coupled with moderate to high genetic advance was recorded for number of effective tillers per meter, and 100 grain volume traits under both conditions. Complementary and duplicate types of interactions were observed depending on trait and environment. Several RILs were reported with presence of beneficial traits, showing negative heat susceptibility indices (HSI) values. The recombinant inbred lines 59 and 106 could be considered the most heat-tolerant recombinant inbred lines which can provide a substantial initiation for future studies and breeding endeavors aimed at creating wheat genotypes that can flourish in heat-stressed environments. [ABSTRACT FROM AUTHOR]

Introduction: In India smoking is a common habit prevalent in both urban and rural areas irrespective of mode of smoking i.e., cigarettes, bidis, pipes, cigar, hookah etc., Spirometry can be helpful to determine effects of smoking on pulmonary functions. We aimed to study the effect of smoking on the pulmonary function tests. Materials and Methods: This study was conducted on 300 subjects including 150 smokers and 150 non-smokers aged between 25 and 60 years attending a tertiary health care center in northern part of our country. Quantification of tobacco smoking was performed by calculating smoking index. All the study subjects underwent spirometry. Results: All the spirometric variables (FVC, FEV1, PEFR, FEF 25-75%) were lower in smokers as compared to non-smokers and this difference was statistically significant. 76% of the smokers had obstructive, 10.7% had normal, 6.7% had restrictive, and 6.7% had mixed pattern on spirometry. 65.3% of the non-smokers had normal, 28.7% had obstructive and 6% had restrictive pattern on spirometry. Conclusion: Almost all the pulmonary function parameters were significantly reduced in smokers compared to non-smokers and obstructive impairment was common amongst smokers. As early quitting is associated with improved survival, it is important that these asymptomatic smokers are identified early and helped to quit. Primary care physicians being the first point of contact, can play a major role. [ABSTRACT FROM AUTHOR]

Sorghum is a multipurpose crop being used as food, feed, fodder and fuel. The objective of the study was to investigate breeding values of new F1 forage sorghum hybrids using line x tester crossing of six A1 cytoplasm type male sterile lines with five fertile local inbred lines and varieties, and 30 F1 hybrids were produced. Both parental lines and their F1 hybrids were field-evaluated for yield and quality traits for two successive years. On the basis of two year hybrids evaluation programme, the lines, 637 A and 753 A were good general combiners for fodder yield and related traits and the lines 467A was found good general combiner for total soluble solids TSS. The testers HJ 541 and IS 2389 were found good general combiners for various yield traits and TSS. On the basis of specific combining ability, the crosses 467A X 2389, 725A X 308, 2219A X G46 and 2219A X HJ 541 were found to be promising for yield related traits. The crosses 467A X 2389, 637AX HJ 541, 637A X HC 308 exhibited good standard heterosis for fodder yield and related traits and the crosses 9A X 2389, 725A X 2389 and 753A X 2389 for TSS. On the basis of above study 467A X 2389 hybrid was found to be promising for fodder yield and related traits. [ABSTRACT FROM AUTHOR]

The CERES-wheat crop growth simulation model has been calibrated and evaluated for two wheat cultivars (PBW 343 and PBW 542) for three sowing dates (30 October, 15 November and 30 November) during 2008-09 and 2009-10 to study partitioning of leaf, stem and grains at Ludhiana, Punjab, India. The experimental data and simulated model data were analysed on partitioning of leaf, stem and grains, and validated. It was found that the model closely simulated the field data from phenological events and biomass. Simulated biological and grain yield was in accordance with-field experiment crop yield within the acceptable range. The correlation coefficient between field-experiment and simulated yield data and biomass data varied significantly from 0.81 and 0.96. The model showed overestimation from field-experimental yield for both cultivars. The cultivar PBW 343 gave higher yield than cultivar PBW 542 on 15 November during both years. The model performance was evaluated and it was found that CERES-wheat model could predict growth parameters like days to anthesis and maturity, biomass and yield with reasonably good accuracy (error less than 8%) and also correlation coefficient between field-experimental and simulated yield data and biomass data varied from 0.94 and 0.95. The results showed that the correlation coefficient between simulated and districts yield varied from 0.41 to 0.78 and also significantly at all six selected districts. The results may be used to improve and evaluate the current practices of crop management at different growth stages of the crop to achieve better production potential. [ABSTRACT FROM AUTHOR]

Northern corn leaf blight (NCLB) of maize, caused by Exserohilum turcicum (Pass.) Leonard and Suggs., is an important foliar disease common across maize-producing areas of the world, including Bihar, India. In this study, virulence and distribution of races were observed against Ht -resistant genes and also identified the E. turcicum race population distribution in Bihar. For that, 45 E. turcicum isolates were collected from maize fields in Bhagalpur, Begusarai, Khagaria, Katihar and Samastipur districts between 2020 and 2022. These isolates were screened on maize differential lines containing Ht1, Ht2, Ht3 and HtN1 resistance genes. Five different physiological races were observed based on the symptoms response of the differential maize lines. These races are race 0, race 1, race 3, race 23N and race 123N. E. turcicum race 3 was the most prevalent race having 26.6% frequency followed by race 0 (24.4%) and race 1 (22.2%) and the least prevalent races were race 23N and 123N having 13.3% each. Varied resistance response of different isolates was observed on differential lines having different resistant genes. Despite the fact that virulence was seen against all Ht resistance genes, NCLB control might be increased by combining qualitative Ht resistance genes with quantitative resistance.

Maize is considered the third most important cereal crop in Asia after rice and wheat. Many diseases affect this crop due to the cultivation of various hybrids. This research aimed to characterize the causative agent of northern corn leaf blight disease in Bihar, India, caused by Exserohilum turcicum (Passerini) Leonard and Suggs. Leaf samples were collected from infected fields in five maize growing districts of Bihar in 2020-2022. A total of 45 fungal isolates from 135 samples were examined for cultural, morphological, and molecular characteristics and were identified as E. turcicum . The isolates were grouped into four groups based on colony color, i.e., olivaceous brown, blackish brown, whitish black, and grayish, and into two groups based on regular and irregular margins. The conidial shapes were observed to be elongated and spindle-shaped with protruding hilum, with conidial septa ranging from 2-12. Similarly, conidial length varied from 52.94 μm to 144.12 μm. β -tubulin gene sequences analysis made it possible to verify the identities of fungal strains and the phylogenetic relationships of all isolates, which were clustered in the same clade. The β -tubulin gene sequences of all the isolates showed a high level of similarity (100%) with reference isolates from GenBank accession numbers KU670342.1, KU670344.1, KU670343.1, KU670341.1, and KU670340.1. The findings of this study will serve as a baseline for future studies and will help to minimize yield losses.

Chylothorax is an uncommon cause of pleural effusion in routine clinical practice. Thoracic surgery, trauma and malignancy are the leading causes of chylothorax accounting for more than 90% of cases.1,2 We report this rare case of a middle aged lady with treated carcinoma breast who presented with left-sided chylothorax secondary to subclavian vein and superior vena cava thrombosis caused by a longstanding indwelling chemo-port in the right internal jugular vein. Patient was managed on total parenteral nutrition (TPN) leading to complete resolution of chylothorax.

Esophageal ultrasound-guided bronchoscopic needle aspiration (EUS-B-NA) is a relatively safe procedure with rare complications. A vasovagal attack after EUS-B-NA has not been reported to date. Usually benign and self-limiting, it can cause refractory bradycardia and sudden cardiac arrest. Timely intervention reduces morbidity and mortality. Here, we report a novel case of vasovagal attack after EUS-B-NA and was managed successfully. Management includes identifying the triggering event and keeping the patient in the Trendelenburg position. Atropine is reserved for refractory cases. (www.actabiomedica.it).

Competing Interests: There are no conflicts of interest.

Introduction: Narrow band imaging (NBI) video bronchoscopy provides better visualisation of submucosal vascular patterns in malignant airway lesions compared to white light bronchoscopy. This analytical cross-sectional study was aimed to look for any relationship between these NBI vascular patterns and the histologic type of lung cancer., Material and Methods: After screening 78 patients with suspected lung cancer, 53 subjects underwent video bronchoscopy. Thirty-two patients showing abnormal bronchial mucosa or endobronchial growth with any of the NBI vascular patterns on bronchoscopy were enrolled in the study. These abnormal areas were then biopsied and sent for histologic examination., Results: NBI bronchoscopy revealed a dilated tortuous vascular pattern in 54.8% of the patients, a non-specific pattern in 32%, a dotted pattern in 9.7% and an abrupt ending vessels pattern in 3.2% of the patients. We did not find any statistically significant relationship between a dilated tortuous pattern and squamous-cell carcinoma (p = 0.48), adenocarcinoma (p = 0.667) or small-cell carcinoma (p = 1); between a dotted pattern and squamous-cell carcinoma (p = 1), adenocarcinoma (p = 0.54) or small-cell carcinoma (p = 1), and between an abrupt ending capillary pattern and squamous-cell carcinoma (p = 1), adenocarcinoma (p = 1) or small-cell carcinoma (p =1)., Conclusion: No relationship exists between NBI vascular patterns and the histology of lung cancer. Endobronchial lesions showing any vascular pattern on NBI needs to be adequately sampled for proper histologic and molecular studies in lung cancer patients.

As no definitive therapy or vaccine is yet available for COVID-19, in a desperate attempt repurposed drugs are being explored as an option. A drug repurposing study identified Ciclesonide as a potential candidate. We reviewed the available evidence and clinical trials on the use of Ciclesonide in COVID-19. At present the evidence is limited to a report of three cases. However, five clinical trials are underway, and their results will help in elucidating the role of Ciclesonide in COVID-19.

We studied the pattern and duration of viral ribonucleic acid (RNA) shedding in 32 asymptomatic and 11 paucisymptomatic coronavirus disease 2019 cases. Viral RNA shedding in exhaled breath progressively diminished and became negative after 6 days of a positive reverse-transcription polymerase chain reaction test. Therefore, the duration of isolation can be minimized to 6 days., (© The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America.)

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Critical central airway obstruction has always been a dreaded complication to which interventional pulmonologist commonly encounters. There have been various modalities which are used for the management and palliation, which includes mechanical coring, laser, cryoextraction, electrocautery and airway stenting. Rigid bronchoscopy with or without jet ventilation has been corner stone of therapeutics and palliation of central airway obstruction. There are only a few conditions where it is not possible to use rigid bronchoscopy. Here we report a case of metastatic tracheal tumour which presented with critical airway obstruction in a patient who had atlantoaxial instability (AAI) due to rheumatoid arthritis. Here we used endobronchial ultrasound scope (EBUS) via esophageal route, i.e. EUS-B guided approach for sampling of the tracheal tumour, and intratumoral chemotherapy was instilled in multiple sessions, which resulted in shrinking of tumour, thus relieving the critical airway obstruction. This is the first report of using EUS-B approach for intratumoral chemotherapy for tracheal tumors. Bronchoscopic intratumoral chemotherapy therapy (BITC) in tracheal tumors is also one of the options but has not been explored much and there has been a dearth of literature for it.

Coronavirus disease 2019, i.e. COVID-19, started as an outbreak in a district of China and has engulfed the world in a matter of 3 months. It is posing a serious health and economic challenge worldwide. However, case fatality rates (CFRs) have varied amongst various countries ranging from 0 to 8.91%. We have evaluated the effect of selected socio-economic and health indicators to explain this variation in CFR. Countries reporting a minimum of 50 cases as on 14th March 2020, were selected for this analysis. Data about the socio-economic indicators of each country was accessed from the World bank database and data about the health indicators were accessed from the World Health Organisation (WHO) database. Various socioeconomic indicators and health indicators were selected for this analysis. After selecting from univariate analysis, the indicators with the maximum correlation were used to build a model using multiple variable linear regression with a forward selection of variables and using adjusted R-squared score as the metric. We found univariate regression results were significant for GDP (Gross Domestic Product) per capita, POD 30/70 (Probability Of Dying Between Age 30 And Exact Age 70 From Any of Cardiovascular Disease, Cancer, Diabetes or Chronic Respiratory Disease), HCI (Human Capital Index), GNI(Gross National Income) per capita, life expectancy, medical doctors per 10000 population, as these parameters negatively corelated with CFR (rho = -0.48 to -0.38 , p<0.05). Case fatality rate was regressed using ordinary least squares (OLS) against the socio-economic and health indicators. The indicators in the final model were GDP per capita, POD 30/70, HCI, life expectancy, medical doctors per 10,000, median age, current health expenditure per capita, number of confirmed cases and population in millions. The adjusted R-squared score was 0.306. Developing countries with a poor economy are especially vulnerable in terms of COVID-19 mortality and underscore the need to have a global policy to deal with this on-going pandemic. These trends largely confirm that the toll from COVID-19 will be worse in countries ill-equipped to deal with it. These analyses of epidemiological data are need of time as apart from increasing situational awareness, it guides us in taking informed interventions and helps policy-making to tackle this pandemic.

Management of pulmonary embolism in post partum females is a challenge. Lower segment caesarean section in past 3 weeks is a contraindication to systemic thrombolysis. Heparin, fondaparinux and warfarin can be safely used in breast-feeding mothers. http://bit.ly/39Nr7qY., Competing Interests: Conflict of interest: K. Deokar has nothing to disclose. Conflict of interest: R. Niwas has nothing to disclose. Conflict of interest: G. Chawla has nothing to disclose. Conflict of interest: N. Chauhan has nothing to disclose., (Copyright ©ERS 2020.)

We used a publicly available data of 44,672 patients reported by China's centre for disease control to study the role of age, sex, co-morbidities and health-care related occupation on COVID-19 mortality. The data is in the form of absolute numbers and proportions. Using the percentages, retrospective synthetic data of 100 survivors and 100 deaths were generated using random number libraries so that proportions of ages, genders, co-morbidities, and occupations were constant as in the original data. Logistic regression of the four predictor factors of age, sex, co-morbidities and occupation revealed that only age and comorbidities significantly affected mortality. Sex and occupation when adjusted for other factors in the equation were not significant predictors of mortality. Age and presence of co-morbidities correlated negatively with survival with co-efficient of -1.23 and -2.33 respectively. Odds ratio (OR) for dying from COVID-19 for every 10-year increase in age was 3.4 compared to the previous band of 10 years. OR for dying of COVID-19 was 10.3 for the presence of any of the co-morbidities. Our findings could help in triaging the patients in the emergency room and emphasize the need to protect the elderly and those with comorbidities from getting exposed.

The causes of cystic lung diseases are varied. Proper evaluation is required for appropriate management. http://bit.ly/37J7dvE., Competing Interests: Conflict of interest: K. Deokar has nothing to disclose. Conflict of interest: R. Niwas has nothing to disclose. Conflict of interest: N. Chauhan has nothing to disclose. Conflict of interest: N. Dutt has nothing to disclose. Conflict of interest: P. Jain has nothing to disclose. Conflict of interest: S. Asfahan has nothing to disclose. Conflict of interest: R. Kumawat has nothing to disclose., (Copyright ©ERS 2020.)

Introduction: Machine learning algorithms have been used to develop prediction models in various infectious and non-infectious settings including interpretation of images in predicting the outcome of diseases. We demonstrate the application of one such simple automated machine learning algorithm to a dataset obtained about COVID-19 spread in South Korea to better understand the disease dynamics., Material and Methods: Data from 20th January 2020 (when the first case of COVID-19 was detected in South Korea) to 4th March 2020 was accessed from Korea's centre for disease control (KCDC). A future time-series of specified length (taken as 7 days in our study) starting from 5th March 2020 to 11th March 2020 was generated and fed to the model to generate predictions with upper and lower trend bounds of 95% confidence intervals. The model was assessed for its ability to reliably forecast using mean absolute percentage error (MAPE) as the metric., Results: As on 4th March 2020, 145,541 patients were tested for COVID-19 (in 45 days) in South Korea of which 5166 patients tested positive. The predicted values approximated well with the actual numbers. The difference between predicted and observed values ranged from 4.08% to 12.77% . On average, our predictions differed from actual values by 7.42% (MAPE) over the same period., Conclusion: Open source and automated machine learning tools like Prophet can be applied and are effective in the context of COVID-19 for forecasting spread in naïve communities. It may help countries to efficiently allocate healthcare resources to contain this pandemic.

A 62 year old male non-smoker diagnosed with pulmonary nocardiosis was initiated on Cotrimoxazole therapy at a dose of 20 mg/kg per day in three divided doses. He developed hyponatremia (serum sodium 105 mEq/L) on day 3 of therapy. The potential causes of hyponatremia were evaluated. After ruling out other causes, the cause was suspected to be Cotrimoxazole-induced syndrome of inappropriate anti-diuretic hormone secretion (SIADH). We subsequently re-initiated therapy with Cotrimoxazole and the hyponatremia (serum sodium 110 mEq/L) recurred. Upon discontinuation of therapy, serum sodium levels returned to normal. The patient was started on Amoxycillin-Clavulanic Acid as an alternative therapy for pulmonary nocardiosis which resulted in resolution of the hyponatremia. Cotrimoxazole-induced SIADH is a rare occurrence. This case is representative of a patient with Cotrimoxazole-induced SIADH and the causal relationship was confirmed once resumption of therapy with the offending medi-cation resulted in hyponatremia. Clinicians should be aware of this rare adverse effect of Cotrimoxazole and should monitor serum electrolytes during therapy, especially in the elderly and in those receiving high doses.

Introduction: Chloroquine and its analogues are currently being investigated for the treatment and post exposure prophylaxis of COVID-19 due to its antiviral activity and immunomodulatory activity., Material and Methods: Confirmed symptomatic cases of COVID-19 were included in the study. Patients were supposed to receive chloroquine (CQ) 500 mg twice daily for 7 days. Due to a change in institutional protocol, initial patients received chloroquine and subsequent patients who did not receive chloroquine served as negative controls. Clinical effectiveness was determined in terms of timing of symptom resolution and conversion rate of reverse transcriptase polymerase chain reaction (RT-PCR) on day 14 and day 15 of admission., Results: Twelve COVID-19 patients formed the treatment arm and 17 patients were included in the control arm. The duration of symptoms among the CQ treated group (6.3 ± 2.7 days) was significantly (p-value = 0.009) lower than that of the control group (8.9 ± 2.2 days). There was no significant difference in the rate of RT-PCR negativity in both groups. 2 patients out of 12 developed diarrhea in the CQ therapy arm., Conclusion: The duration of symptoms among the treated group (with chloroquine) was significantly lower than that of the control group. RT-PCR conversion was not significantly different between the 2 groups.