201. Clinical implications of β-catenin protein expression in breast cancer.
- Author
-
Wang Z, Zhang H, Hou J, Niu J, Ma Z, Zhao H, and Liu C
- Subjects
- Adult, Aged, Breast Neoplasms metabolism, Breast Neoplasms mortality, Female, Humans, Immunohistochemistry, Kaplan-Meier Estimate, Middle Aged, Prognosis, Proportional Hazards Models, Survival Analysis, beta Catenin analysis, Biomarkers, Tumor analysis, Breast Neoplasms pathology, beta Catenin biosynthesis
- Abstract
The objective of this study was to examine the expression and significance of β-catenin in the diagnosis and prognosis of breast cancer. Overall, 241 patients with histologically confirmed breast cancer who had undergone radical surgery were enrolled in this study. β-catenin protein expression in breast cancer samples was evaluated by immunohistochemistry. β-catenin was expressed in Nuclei/Plasma of the samples from 41 patients. β-catenin protein expression correlated with the histological grade of the tumor (P<0.05) and Ki-67 labeling (P<0.01). Survival analysis showed that β-catenin expression negatively correlated with breast cancer-specific survival. Our results showed prominent expression of β-catenin in breast cancer and strongly implicate the β-catenin in tumor promotion.
- Published
- 2015