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1,662 results on '"Li, Xiao‐Mei"'

422. Saponins from Rhizoma Panacis Majoris attenuate myocardial ischemia/reperfusion injury via the activation of the Sirt1/Foxo1/Pgc-1α and Nrf2/antioxidant defense pathways in rats

Author

Li, Dao-Jun, primary, Chen, Mao-Hua, primary, He, Hai-Bo, additional, Li, Xiao-Mei, additional, Ding, Yong-Hong, additional, Zhang, Yong-Feng, additional, Xu, Hai-Yan, additional, Feng, Min-Lu, additional, Xiang, Chang-Qing, additional, Zhou, Ji-Gang, additional, Zhang, Ji-Hong, additional, and Liu, Hong-Jun, additional

Published
2018
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424. iTRAQ analysis of a mouse acute myocardial infarction model reveals that vitamin D binding protein promotes cardiomyocyte apoptosis after hypoxia

Author

Wu, Yun, primary, Liu, Fen, additional, Ma, Xiang, additional, Adi, Dilare, additional, Gai, Ming-Tao, additional, Jin, Xiang, additional, Yang, Yi-Ning, additional, Huang, Ying, additional, Xie, Xiang, additional, Li, Xiao-Mei, additional, Fu, Zhen-Yan, additional, Chen, Bang-Dang, additional, and Ma, Yi-Tong, additional

Published
2017
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426. Quercetin induces ferroptosis by inactivating mTOR/S6KP70 pathway in oral squamous cell carcinoma.

Author

Zhu, Ya-Wen, Liu, Chun-Lei, Li, Xiao-Mei, and Shang, Yu

Subjects
*QUERCETIN, *SQUAMOUS cell carcinoma, *MTOR inhibitors, *ANTINEOPLASTIC agents, *GLUTAMATE transporters, *WESTERN immunoblotting
Abstract

Although recent studies increasingly suggest the potential anti-cancer effect of quercetin, the exact underlying mechanism remains poorly demonstrated in oral squamous cell carcinoma (oSCC). Therefore, our research explored the impacts of quercetin on the ferroptosis and mTOR/S6KP70 axis in oSCC cell lines. After treating oSCC cells with quercetin or indicated compounds and transfection with SLC7A11- or S6KP70-overexpressing plasmid, cell viability was detected by CCK-8 assay. The level of ferroptosis in oSCC cells was assessed by measuring ROS and GSH levels. The activation of mTOR/S6KP70 axis was assessed by Western blotting. Quercetin promoted ferroptosis in an mTOR/S6KP70-dependent manner to inhibit tumor growth in oSCC cells. Mechanistically, we revealed that quercetin induced lipid peroxidation and reduced GSH levels by repressing SLC7A11 expression in oSCC cells. Specifically, the effects of quercetin on ferroptosis and mTOR and S6KP70 phosphorylation were partially blocked by both mTOR agonist and S6KP70 overexpression. Moreover, mTOR inhibitor promoted ferroptosis in quercetin-treated oSCC cells. Our findings showed that ferroptosis may be a new anti-tumor mechanism of quercetin. Additionally, we identified that quercetin can target mTOR/S6KP70 cascade to inhibit the growth of oSCC cells. [ABSTRACT FROM AUTHOR]

Published
2024
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428. The circadian timing system as a toxicity target of the anticancer mTOR inhibitor everolimus in mice

Author

OZTURK, N., ÖZTÜRK, DİLEK, PALA-KARA, Z., Kaptan, Engin, Sancar Baş, Serap, Çınar, Suzan, Deniz, Günnur, Giachetti, Sylvie, Li, Xiao Mei, Levi, Francis, OKYAR, ALPER, and ÖZTÜRK CİVELEK, DİLEK

Subjects
OZTURK N., ÖZTÜRK D., PALA-KARA Z., Kaptan E., Sancar Baş S., Çınar S., Deniz G., Li X. M. , Giachetti S., Levi F., et al., -The circadian timing system as a toxicity target of the anticancer mTOR inhibitor everolimus in mice.-, 7. European Congress of Pharmacology, İstanbul, Türkiye, 26 June 2016, ss.30
Published
2016

429. Dosing-Time Dependent Reproductive Toxicity of Everolimus in Male Mice

Author

Öztürk, Narin, ÖZTÜRK, DİLEK, Pala Kara, Zeliha, Kaptan, Engin, Sancar Baş, Serap, Li, Xiao Mei, Levi, Francis, Okyar, Alper, and ÖZTÜRK CİVELEK, DİLEK

Subjects
Öztürk N., ÖZTÜRK D., Pala Kara Z., Kaptan E., Sancar Baş S., Li X. M. , Levi F., Okyar A., -Dosing-Time Dependent Reproductive Toxicity of Everolimus in Male Mice.-, 2016 Society for Research on Biological Rhythms Meeting, Palm Harbor, Florida, Amerika Birleşik Devletleri, 21 May 2016, ss.208
Published
2016

430. Chronotoxicity of Everolimus on the Immune System

Author

ÖZTÜRK, DİLEK, Öztürk, Narin, Pala Kara, Zeliha, Kaptan, Engin, Sancar Baş, Serap, Çınar, Suzan, Deniz, Günnur, Li, Xiao Mei, Levi, Francis, Okyar, Alper, and ÖZTÜRK CİVELEK, DİLEK

Subjects
ÖZTÜRK D., Öztürk N., Pala Kara Z., Kaptan E., Sancar Baş S., Çınar S., Deniz G., Li X. M. , Levi F., Okyar A., -Chronotoxicity of Everolimus on the Immune System.-, 2016 Society for Research on Biological Rhythms Meeting, Palm Harbor, Florida, Amerika Birleşik Devletleri, 21 May 2016, ss.172-173
Published
2016

431. Importance and benefits of dietary sodium restriction in the management of chronic kidney disease patients: experience from a single Chinese center

Author

Wang Yu, Wang Hai-yan, LI Xiao-mei, and Sun Luying

Subjects
Adult, Male, Nephrology, China, medicine.medical_specialty, Urinalysis, Cross-sectional study, Urology, Sodium, chemistry.chemical_element, urologic and male genital diseases, Internal medicine, Prevalence, medicine, Humans, Intensive care medicine, Aged, Retrospective Studies, Proteinuria, medicine.diagnostic_test, business.industry, Sodium, Dietary, Retrospective cohort study, Diet, Sodium-Restricted, Middle Aged, medicine.disease, female genital diseases and pregnancy complications, Circadian Rhythm, Cross-Sectional Studies, Blood pressure, chemistry, Disease Progression, Kidney Failure, Chronic, Female, medicine.symptom, business, Follow-Up Studies, Kidney disease
Abstract

Several studies have suggested that sodium intake may affect blood pressure (BP), proteinuria, and intrarenal transforming growth factor-β1 (TGF-β1) production in patients and animal models with chronic kidney disease (CKD). The Chinese population has a high prevalence of CKD and is well known for consuming salty foods. This study will investigate the role of dietary sodium intake on BP control among non-dialysis Chinese CKD patients.A cross-sectional study was carried out in a cohort of 176 non-dialysis hypertensive CKD patients to investigate their sodium intake and its effect on BP control by measuring 24-h urine sodium excretion (24-h UNa). A total of 20 patients with immunoglobulin A nephropathy (IgAN) participated in a 7-day sodium restriction study (100 mmol/day). Their changes in BP, proteinuria, and urinary TGF-β1 excretion were subsequently analyzed. Another 23 IgAN patients without salt restriction were included as controls.The average 24-h UNa of the study cohort was 149.0 ± 66.4 mmol/day. Only 31.8% patients had a 24-h UNa less than 100 mmol/day. The OR for each 17 mmol increment in 24-h UNa (salt 1 g/day) for BP130/80 mmHg was 1.26 (95% CI 1.10-1.44, P = 0.001). The sodium restriction group achieved significantly more reduction in SBP (-11.1 mmHg vs. -5.0 mmHg, P = 0.022), DBP (-9.4 mmHg vs. -2.1 mmHg, P = 0.009), and urine protein excretion [-465 (-855 to -340) mg/day vs. -150 (-570 to 40) mg/day, P = 0.024]. A positive correlation was observed between the change of 24-h UNa and the change of SBP (r = 0.450, P = 0.047) in the sodium restriction group. The change of 24-h UNa was also correlated with the 24-h TGF-β1 excretion (r = 0.558, P = 0.011) in these patients.Dietary sodium intake restriction should be monitored and intensified in the treatment of Chinese CKD patients.

Published
2011

436. Isolation and Identification of Rickettsia raoultii in Human Cases: A Surveillance Study in 3 Medical Centers in China

Author

Li, Hao, primary, Zhang, Pan-He, additional, Huang, Yong, additional, Du, Juan, additional, Cui, Ning, additional, Yang, Zhen-Dong, additional, Tang, Fang, additional, Fu, Fei-Xiang, additional, Li, Xiao-Mei, additional, Cui, Xiao-Ming, additional, Fan, Ya-Di, additional, Xing, Bo, additional, Li, Xiao-Kun, additional, Tong, Yi-Gang, additional, Cao, Wu-Chun, additional, and Liu, Wei, additional

Published
2017
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438. Association of genetic variations in the lipid regulatory pathway genes FBXW7 and SREBPs with coronary artery disease among Han Chinese and Uygur Chinese populations in Xinjiang, China

Author

Abudesimu, Asiya, primary, Adi, Dilare, additional, Siti, Dilixiati, additional, Xie, Xiang, additional, Yang, Yi-Ning, additional, Li, Xiao-Mei, additional, Wang, Ying-Hong, additional, Wang, Yong-Tao, additional, Meng, Ya-Jie, additional, Liu, Fen, additional, Chen, Bang-Dang, additional, Ma, Xiang, additional, Fu, Zhen-Yan, additional, and Ma, Yi-Tong, additional

Published
2017
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