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1,242 results on '"Lee, Joseph H."'

406. Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma

Author

Christensen, James G., primary, Zou, Helen Y., additional, Arango, Maria E., additional, Li, Qiuhua, additional, Lee, Joseph H., additional, McDonnell, Scott R., additional, Yamazaki, Shinji, additional, Alton, Gordon R., additional, Mroczkowski, Barbara, additional, and Los, Gerrit, additional

Published
2007
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408. Age-at-onset linkage analysis in Caribbean Hispanics with familial late-onset Alzheimer’s disease

Author

Lee, Joseph H., primary, Barral, Sandra, additional, Cheng, Rong, additional, Chacon, Inara, additional, Santana, Vincent, additional, Williamson, Jennifer, additional, Lantigua, Rafael, additional, Medrano, Martin, additional, Jimenez-Velazquez, Ivonne Z., additional, Stern, Yaakov, additional, Tycko, Benjamin, additional, Rogaeva, Ekaterina, additional, Wakutani, Yosuke, additional, Kawarai, Toshitaka, additional, St George-Hyslop, Peter, additional, and Mayeux, Richard, additional

Published
2007
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410. An Orally Available Small-Molecule Inhibitor of c-Met, PF-2341066, Exhibits Cytoreductive Antitumor Efficacy through Antiproliferative and Antiangiogenic Mechanisms

Author

Zou, Helen Y., primary, Li, Qiuhua, additional, Lee, Joseph H., additional, Arango, Maria E., additional, McDonnell, Scott R., additional, Yamazaki, Shinji, additional, Koudriakova, Tatiana B., additional, Alton, Gordon, additional, Cui, Jingrong J., additional, Kung, Pei-Pei, additional, Nambu, Mitchell D., additional, Los, Gerrit, additional, Bender, Steven L., additional, Mroczkowski, Barbara, additional, and Christensen, James G., additional

Published
2007
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411. The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease

Author

Rogaeva, Ekaterina, primary, Meng, Yan, additional, Lee, Joseph H, additional, Gu, Yongjun, additional, Kawarai, Toshitaka, additional, Zou, Fanggeng, additional, Katayama, Taiichi, additional, Baldwin, Clinton T, additional, Cheng, Rong, additional, Hasegawa, Hiroshi, additional, Chen, Fusheng, additional, Shibata, Nobuto, additional, Lunetta, Kathryn L, additional, Pardossi-Piquard, Raphaelle, additional, Bohm, Christopher, additional, Wakutani, Yosuke, additional, Cupples, L Adrienne, additional, Cuenco, Karen T, additional, Green, Robert C, additional, Pinessi, Lorenzo, additional, Rainero, Innocenzo, additional, Sorbi, Sandro, additional, Bruni, Amalia, additional, Duara, Ranjan, additional, Friedland, Robert P, additional, Inzelberg, Rivka, additional, Hampe, Wolfgang, additional, Bujo, Hideaki, additional, Song, You-Qiang, additional, Andersen, Olav M, additional, Willnow, Thomas E, additional, Graff-Radford, Neill, additional, Petersen, Ronald C, additional, Dickson, Dennis, additional, Der, Sandy D, additional, Fraser, Paul E, additional, Schmitt-Ulms, Gerold, additional, Younkin, Steven, additional, Mayeux, Richard, additional, Farrer, Lindsay A, additional, and St George-Hyslop, Peter, additional

Published
2007
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413. Coding mutations in SORL 1 and Alzheimer disease.

Author

Vardarajan, Badri N., Zhang, Yalun, Lee, Joseph H., Cheng, Rong, Bohm, Christopher, Ghani, Mahdi, Reitz, Christiane, Reyes‐Dumeyer, Dolly, Shen, Yufeng, Rogaeva, Ekaterina, St George‐Hyslop, Peter, and Mayeux, Richard

Abstract

Objective Common single nucleotide polymorphisms in the SORL1 gene have been associated with late onset Alzheimer disease (LOAD), but causal variants have not been fully characterized nor has the mechanism been established. The study was undertaken to identify functional SORL1 mutations in patients with LOAD. Methods This was a family- and cohort-based genetic association study. Caribbean Hispanics with familial and sporadic LOAD and similarly aged controls were recruited from the United States and the Dominican Republic, and patients with sporadic disease of Northern European origin were recruited from Canada. Prioritized coding variants in SORL1 were detected by targeted resequencing and validated by genotyping in additional family members and unrelated healthy controls. Variants transfected into human embryonic kidney 293 cell lines were tested for Aβ40 and Aβ42 secretion, and the amount of the amyloid precursor protein (APP) secreted at the cell surface was determined. Results Seventeen coding exonic variants were significantly associated with disease. Two rare variants (rs117260922-E270K and rs143571823-T947M) with minor allele frequency (MAF) < 1% and 1 common variant (rs2298813-A528T) with MAF = 14.9% segregated within families and were deemed deleterious to the coding protein. Transfected cell lines showed increased Aβ40 and Aβ42 secretion for the rare variants (E270K and T947M) and increased Aβ42 secretion for the common variant (A528T). All mutants increased the amount of APP at the cell surface, although in slightly different ways, thereby failing to direct full-length APP into the retromer-recycling endosome pathway. Interpretation Common and rare variants in SORL1 elevate the risk of LOAD by directly affecting APP processing, which in turn can result in increased Aβ40 and Aβ42 secretion. Ann Neurol 2015;77:215-227 [ABSTRACT FROM AUTHOR]

Published
2015
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417. P1-316

Author

Medrano, Martin A., primary, Lantigua, Rafael, additional, Santana, Vincent, additional, Lee, Joseph H., additional, Stern, Yaakov, additional, Tycko, Benjamin, additional, and Mayeux, Richard, additional

Published
2006
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419. P1-304: Fine mapping of 12p for memory traits: A complementary approach to understanding the genetics of Alzheimer's disease

Author

Lee, Joseph H., primary, Lee, Hye-Seung, additional, Cheng, Rong, additional, Santana, Vincent, additional, Williamson, Jennifer, additional, Lantigua, Rafael, additional, Medrano, Martin, additional, Tycko, Benjamin, additional, Rogaeva, Ekaterina, additional, St. George-Hyslop, Peter, additional, Stern, Yaakov, additional, and Mayeux, Richard, additional

Published
2006
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425. O3-02-08 Fine mapping of chromosome 10 using memory and related neuropsychological phenotypes in the Caribbean hispanics

Author

Lee, Joseph H., primary, Mayo, David, additional, Mo, Jianh, additional, Santana, Vincent, additional, Williamson, Jennifer, additional, Flaquer, Antonia, additional, Estevez, Pedro, additional, Lantigua, Rafael, additional, Kawarai, Toshitaka, additional, Toulina, Anna, additional, Medrano, Martin, additional, Stern, Yaakov, additional, Tycko, Benjamin, additional, Rogaeva, Ekaterina, additional, George-Hyslop, Peter St, additional, Knowles, James A., additional, and Mayeux, Richard, additional

Published
2004
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449. Waste disposal in the ocean

Author

Jirka, Gerhard H., Lee, Joseph H W, Jirka, Gerhard H., and Lee, Joseph H W

Abstract

This review is structured into four main sections. First, the three major types of discharge into coastal receiving water are discussed: by means of a single submerged pipe outfall; a multiple port (multiport) submerged diffuser outfall; and surface discharge by means of a canal at the shoreline. All of these discharges produce jet-like motions that are modified in various ways by buoyancy, ambient geometry, and ambient currents. The emphasis in these three sections is to provide a classification of the behaviour of these discharges and to present simple methods for predicting their mixing capacity (near field dilution). Predictive methods for far field transport processes are then discussed. The application of simple models that are readily applied for approximate analysis is stressed. -from Authors

Published
1994

450. The occurrence and ecological risks of endocrine disrupting chemicals in sewage effluents from three different sewage treatment plants, and in natural seawater from a marine reserve of Hong Kong.

Author

Xu, Elvis G. B., Shan Liu, Guang-Guo Ying, Zheng, Gene J. S., Lee, Joseph H. W., and Leung, Kenneth M. Y.

Subjects
SEWAGE disposal plants, ECOLOGICAL risk assessment, ENDOCRINE disruptors, SEAWATER, MARINE parks & reserves
Abstract

We determined the concentrations of 12 endocrine disrupting chemicals (EDCs) in sewage effluents collected from three different sewage treatment plants (STPs) in Hong Kong, and found 4-nonylphenol (NP) and bisphenol A (BPA) were the most abundant EDCs. Effluent concentrations of NP and BPA were higher in dry season than in wet season, but opposite seasonal changes of NP were observed in receiving waters, probably due to the surface runoff. The two secondary STPs showed higher removal efficiency for these compounds than the preliminary STP, while having higher removal efficiency in wet season. Therefore, it is necessary to upgrade the preliminary STP and improve the EDC removal efficiency in dry season. Seawaters from the Cape D' Aguilar Marine Reserve adjacent to these STPs also exhibited elevated NP levels with a hazard quotient >1. Furthermore, diluted effluents from the STPs elicited significant transcriptional responses of EDC-related genes in the marine medaka fish. [ABSTRACT FROM AUTHOR]

Published
2014
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