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43,695 results on '"Klotz, A."'

401. Utility of digital rectal examination in a population with prostate cancer treated with active surveillance

Author

Herrera-Caceres, Jaime O, Wettstein, Marian S, Goldberg, Hanan, Toi, Ants, Chandrasekar, Thenappan, Woon, Dixon TS, Ahmad, Ardalan E, Sanmamed-Salgado, Noelia, Alhunaidi, Omar, Ajib, Khaled, Nason, Gregory, Tan, Guan Hee, Fleshner, Neil, and Klotz, Laurence

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Aging, Cancer, Clinical Research, Prostate Cancer, Prevention, Urologic Diseases, Detection, screening and diagnosis, 4.1 Discovery and preclinical testing of markers and technologies, 4.2 Evaluation of markers and technologies, Urology & Nephrology, Clinical sciences, Oncology and carcinogenesis
Abstract

IntroductionDigital rectal examination (DRE) is part of the clinical evaluation of men on active surveillance (AS). The purpose of the present study is to analyze the value of DRE as a predictor of upgrading in a population of men with prostate cancer (PCa) treated with AS.MethodsWe used the prostate biopsy (PBx) database from an academic center, including PBx from 2006-2018, and identified 2029 confirmatory biopsies (CxPBx) of men treated with AS, of which 726 men had both diagnostic (initial) and CxPBx information available. We did a descriptive analysis and evaluated sensitivity, specificity, and predictive values of DRE for the detection of clinically significant PCa (csPCa). Multivariable regression analysis was done to identify predictors of csPCa. The primary outcome was to evaluate DRE as a predictor of the presence of csPCa at CxPBx.ResultsAmong the 2029 patients with a CxPBx, 75% had PCa, and of these, 30.3% had upgrading to International Society of Urologic Pathologists (ISUP) grade ≥2. Thirteen percent of men had a suspicious DRE (done by their treating physician). Sensitivity, specificity, negative and positive predictive values of DRE to detect csPCa were best with a prostate-specific antigen (PSA)

Published
2020

402. Prostate cancer mortality and metastasis under different biopsy frequencies in North American active surveillance cohorts

Author

Lange, Jane M, Laviana, Aaron A, Penson, David F, Lin, Daniel W, Bill‐Axelson, Anna, Carlsson, Sigrid V, Newcomb, Lisa F, Trock, Bruce J, Carter, H Ballentine, Carroll, Peter R, Cooperberg, Mathew R, Cowan, Janet E, Klotz, Laurence H, and Etzioni, Ruth B

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Prostate Cancer, Cancer, Aging, Urologic Diseases, Prevention, Clinical Research, Good Health and Well Being, Aged, Aged, 80 and over, Biopsy, Cohort Studies, Disease Progression, Humans, Male, Middle Aged, Neoplasm Grading, Neoplasm Metastasis, North America, Prostate, Prostate-Specific Antigen, Prostatic Neoplasms, Quality-Adjusted Life Years, Risk Assessment, San Francisco, United States, White People, active surveillance, biopsy, Gleason score, microsimulation, prostate cancer, Public Health and Health Services, Oncology & Carcinogenesis, Oncology and carcinogenesis, Public health
Abstract

BackgroundActive surveillance (AS) is an accepted means of managing low-risk prostate cancer. Because of the rarity of downstream events, data from existing AS cohorts cannot yet address how differences in surveillance intensity affect metastasis and mortality. This study projected the comparative benefits of different AS schedules in men diagnosed with prostate cancer who had Gleason score (GS) ≤6 disease and risk profiles similar to those in North American AS cohorts.MethodsTimes of GS upgrading were simulated based on AS data from the University of Toronto, Johns Hopkins University, the University of California at San Francisco, and the Canary Pass Active Surveillance Cohort. Times to metastasis and prostate cancer death, informed by models from the Scandinavian Prostate Cancer Group 4 trial, were projected under biopsy surveillance schedules ranging from watchful waiting to annual biopsies. Outcomes included the risk of metastasis, the risk of death, remaining life-years (LYs), and quality-adjusted LYs.ResultsCompared with watchful waiting, AS biopsies reduced the risk of prostate cancer metastasis and prostate cancer death at 20 years by 1.4% to 3.3% and 1.0% to 2.4%, respectively; and 5-year biopsies reduced the risk of metastasis and prostate cancer death by 1.0% to 2.4% and 0.6% to 1.6%, respectively. There was little difference between annual and 5-year biopsy schedules in terms of LYs (range of differences, 0.04-0.16 LYs) and quality-adjusted LYs (range of differences, -0.02 to 0.09 quality-adjusted LYs).ConclusionsAmong men diagnosed with GS ≤6 prostate cancer, obtaining a biopsy every 3 or 4 years appears to be an acceptable alternative to more frequent biopsies. Reducing surveillance intensity for those who have a low risk of progression reduces the number of biopsies while preserving the benefit of more frequent schedules.

Published
2020

403. A novel method for predicting hepatocellular carcinoma response to chemoembolization using an intraprocedural CT hepatic arteriography-based enhancement mapping: a proof-of-concept analysis

Author

Ryosuke Taiji, Yuan-Mao Lin, Gouthami Chintalapani, Ethan Y. Lin, Steven Y. Huang, Armeen Mahvash, Rony Avritscher, Chien-An Liu, Rheun-Chuan Lee, Vivian Resende, Hideyuki Nishiofuku, Toshihiro Tanaka, Kimihiko Kichikawa, Ernst Klotz, Sanjay Gupta, and Bruno C. Odisio

Subjects
Carcinoma (hepatocellular), Chemoembolization (therapeutic), Computed tomography angiography, Cone-beam computed tomography, Microspheres, Medical physics. Medical radiology. Nuclear medicine, R895-920
Abstract

Abstract Background To evaluate the feasibility of a novel approach for predicting hepatocellular carcinoma (HCC) response to drug-eluting beads transarterial chemoembolization (DEB-TACE) using computed tomography hepatic arteriography enhancement mapping (CTHA-EM) method. Methods This three-institution retrospective study included 29 patients with 46 HCCs treated with DEB-TACE between 2017 and 2020. Pre- and posttreatment CTHA-EM images were generated using a prototype deformable registration and subtraction software. Relative tumor enhancement (T Post/pre-RE) defined as the ratio of tumor enhancement to normal liver tissue was calculated to categorize tumor response as residual (T Post-RE > 1) versus non-residual (T Post-RE ≤ 1) enhancement, which was blinded compared to the response assessment on first follow-up imaging using modified RECIST criteria. Additionally, for tumors with residual enhancement, CTHA-EM was evaluated to identify its potential feeding arteries. Results CTHA-EM showed residual enhancement in 18/46 (39.1%) and non-residual enhancement in 28/46 (60.9%) HCCs, with significant differences on T Post-RE (3.05 ± 2.4 versus 0.48 ± 0.23, respectively; p < 0.001). The first follow-up imaging showed non-complete response (partial response or stable disease) in 19/46 (41.3%) and complete response in 27/46 (58.7%) HCCs. CTHA-EM had a response prediction sensitivity of 94.7% (95% CI, 74.0–99.9) and specificity of 100% (95% CI, 87.2–100). Feeding arteries to the residual enhancement areas were demonstrated in all 18 HCCs (20 arteries where DEB-TACE was delivered, 2 newly developed collaterals following DEB-TACE). Conclusion CTHA-EM method was highly accurate in predicting initial HCC response to DEB-TACE and identifying feeding arteries to the areas of residual arterial enhancement.

Published
2023
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404. Caravan - A global community dataset for large-sample hydrology

Author

Frederik Kratzert, Grey Nearing, Nans Addor, Tyler Erickson, Martin Gauch, Oren Gilon, Lukas Gudmundsson, Avinatan Hassidim, Daniel Klotz, Sella Nevo, Guy Shalev, and Yossi Matias

Subjects
Science
Abstract

Abstract High-quality datasets are essential to support hydrological science and modeling. Several CAMELS (Catchment Attributes and Meteorology for Large-sample Studies) datasets exist for specific countries or regions, however these datasets lack standardization, which makes global studies difficult. This paper introduces a dataset called Caravan (a series of CAMELS) that standardizes and aggregates seven existing large-sample hydrology datasets. Caravan includes meteorological forcing data, streamflow data, and static catchment attributes (e.g., geophysical, sociological, climatological) for 6830 catchments. Most importantly, Caravan is both a dataset and open-source software that allows members of the hydrology community to extend the dataset to new locations by extracting forcing data and catchment attributes in the cloud. Our vision is for Caravan to democratize the creation and use of globally-standardized large-sample hydrology datasets. Caravan is a truly global open-source community resource.

Published
2023
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405. Occurrence of filamentous fungi in yerba mate discarded in the environment

Author

Ana Luiza Klotz-Neves, Fernando Augusto Bertazzo-Silva, Lilian Maggio, Marines de Avila Heberle, Vanessa dos Anjos Baptista, and Jair Putzke

Subjects
ilex paraguariensis, mycodiversity, phytopathology, residue, succession fungal, taxonomy, Agriculture, Agriculture (General), S1-972
Abstract

Yerba mate, Ilex paraguariensis A. St. Hil. (Aquifoliaceae), waste is one of the most common byproducts generated in households in southern Brazil due to the traditional consumption of mate. However, the decomposition of this waste by fungi has not been thoroughly evaluated. In order to study the fungal succession in mate residue, 450 samples were evaluated during the autumn, winter, and spring, and kept for two months in a humid chamber (aerobic medium) for the growth of associated filamentous fungi. We morphologically identified the fungi by means of a microscopy device and taking into consideration only the surface-developed mycelia. Twenty-two genera of filamentous fungi were found, of which the Zygomycota (Rhizopus spp. and Mucor spp.) microflora deserve special attention since they were the only fungi growing in the first 19 days. After this period, the fungi Deuteromycota (mainly Aspergillus spp.) and Oomycota (Pythium spp.) develop more vigorously, supplanting the previous ones. The species of Curvularia, Fusarium, Verticillium, and Pythium are phytopathogens and end up having their inoculum source increased with the irregular disposal of this residue in nature. The presence of numerous fungal genera, which are known to be pathogenic according to the literature, highlights the importance of implementing proper waste disposal practices in the environment. Improper disposal of the yerba mate waste can result in contamination not only of yerba mate itself but also of other commercial crops. Therefore, it is imperative that greater attention be paid to the disposal of this waste.

Published
2022
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406. Extensive testing of a multi-locus sequence typing scheme for Giardia duodenalis assemblage A confirms its good discriminatory power

Author

Christian Klotz, Anna Rosa Sannella, Filip Weisz, Umer Chaudhry, Jacek Sroka, Pavla Tůmová, Eva Nohýnková, Ralf Ignatius, Toni Aebischer, Martha Betson, Karin Troell, and Simone M. Cacciò

Subjects
Molecular epidemiology, Zoonotic transmission, Source tracing, MLST, Outbreak, Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background The flagellated parasite Giardia duodenalis is a major and global cause of diarrhoeal disease. Eight genetically very distinct groups, known as assemblages A to H, have been recognized in the G. duodenalis species complex, two of which (assemblages A and B) infect humans and other mammalian hosts. Informative typing schemes are essential to understand transmission pathways, characterize outbreaks and trace zoonotic transmission. In this study, we evaluated a published multi-locus sequence typing (MLST) scheme for G. duodenalis assemblage A, which is based on six polymorphic markers. Methods We genotyped 60 human-derived and 11 animal-derived G. duodenalis isolates collected in Europe and on other continents based on the published protocol. After retrieving previously published genotyping data and excluding isolates whose sequences showed allelic sequence heterozygosity, we analysed a dataset comprising 146 isolates. Results We identified novel variants at five of the six markers and identified 78 distinct MLST types in the overall dataset. Phylogenetic interpretation of typing data confirmed that sub-assemblage AII only comprises human-derived isolates, whereas sub-assemblage AI comprises all animal-derived isolates and a few human-derived isolates, suggesting limited zoonotic transmission. Within sub-assemblage AII, isolates from two outbreaks, which occurred in Sweden and Italy, respectively, had unique and distinct MLST types. Population genetic analysis showed a lack of clustering by geographical origin of the isolates. Conclusion The MLST scheme evaluated provides sufficient discriminatory power for epidemiological studies of G. duodenalis assemblage A. Graphical Abstract

Published
2022
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408. Management of patients with advanced prostate cancer—metastatic and/or castration-resistant prostate cancer: Report of the Advanced Prostate Cancer Consensus Conference (APCCC) 2022

Author

Gillessen, Silke, Bossi, Alberto, Davis, Ian D., de Bono, Johann, Fizazi, Karim, James, Nicholas D., Mottet, Nicolas, Shore, Neal, Small, Eric, Smith, Matthew, Sweeney, Christopher J., Tombal, Bertrand, Antonarakis, Emmanuel S., Aparicio, Ana M., Armstrong, Andrew J., Attard, Gerhardt, Beer, Tomasz M., Beltran, Himisha, Bjartell, Anders, Blanchard, Pierre, Briganti, Alberto, Bristow, Rob G., Bulbul, Muhammad, Caffo, Orazio, Castellano, Daniel, Castro, Elena, Cheng, Heather H., Chi, Kim N., Chowdhury, Simon, Clarke, Caroline S., Clarke, Noel, Daugaard, Gedske, De Santis, Maria, Duran, Ignacio, Eeles, Ross, Efstathiou, Eleni, Efstathiou, Jason, Ekeke, Onyeanunam Ngozi, Evans, Christopher P., Fanti, Stefano, Feng, Felix Y., Fonteyne, Valerie, Fossati, Nicola, Frydenberg, Mark, George, Dan, Gleave, Martin, Gravis, Gwenaelle, Halabi, Susan, Heinrich, Daniel, Herrmann, Ken, Higano, Celestia, Hofman, Michael S., Horvath, Lisa G., Hussain, Maha, Jereczek-Fossa, Barbara A., Jones, Rob, Kanesvaran, Ravindran, Kellokumpu-Lehtinen, Pirkko-Liisa, Khauli, Raja B., Klotz, Laurence, Kramer, Gero, Leibowitz, Raja, Logothetis, Christopher, Mahal, Brandon, Maluf, Fernando, Mateo, Joaquin, Matheson, David, Mehra, Niven, Merseburger, Axel, Morgans, Alicia K., Morris, Michael J., Mrabti, Hind, Mukherji, Deborah, Murphy, Declan G., Murthy, Vedang, Nguyen, Paul L., Oh, William K., Ost, Piet, O’Sullivan, Joe M., Padhani, Anwar R., Pezaro, Carmel J., Poon, Darren M.C., Pritchard, Colin C., Rabah, Danny M., Rathkopf, Dana, Reiter, Robert E., Rubin, Mark A., Ryan, Charles J., Saad, Fred, Sade, Juan Pablo, Sartor, Oliver, Scher, Howard I., Sharifi, Nima, Skoneczna, Iwona, Soule, Howard, Spratt, Daniel E., Srinivas, Sandy, Sternberg, Cora N., Steuber, Thomas, Suzuki, Hiroyoshi, Sydes, Matthew R., Taplin, Mary-Ellen, Tilki, Derya, Türkeri, Levent, Turco, Fabio, Uemura, Hiroji, Uemura, Hirotsugu, Ürün, Yüksel, Vale, Claire L., van Oort, Inge, Vapiwala, Neha, Walz, Jochen, Yamoah, Kosj, Ye, Dingwei, Yu, Evan Y., Zapatero, Almudena, Zilli, Thomas, and Omlin, Aurelius

Published
2023
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410. Safety and efficacy of rozanolixizumab in patients with generalised myasthenia gravis (MycarinG): a randomised, double-blind, placebo-controlled, adaptive phase 3 study

Author

Genge, Angela, Massie, Rami, Berube, Maxime, Bril, Vera, Daniyal, Lubna, Mannan, Shabber, Ng, Eduardo, Raman, Ritesh Rohan Raghu, Sarpong, Evelyn, Alcantara, Monica, Dionne, Annie, Siddiqi, Zaeem, Blackmore, Derrick, Hussain, Faraz, Matte, Genevieve, Botez, Stephan, Tyblova, Michaela, Jakubikova, Michala, Junkerova, Jana, Vissing, John, Witting, Nanna, Holm-Yildiz, Sonja, Stemmerik, Mads, Andersen, Henning, Obál, Izabella, Solé, Guilhem, Mathis, Stéphane, Violleau, Marie-Hélène, Tranchant, Christine, Messai, Sihame, Chanson, Jean-Baptiste, Nadaj-Pakleza, Aleksandra, Verloes, Arnaud, Zaidi, Leila, Sacconi, Sabrina, Gambella, Manuela, Cavalli, Michele, Stojkovic, Tanya, Demeret, Sophie, Le Guennec, Loic, Querin, Giorgia, Weiss, Nicolas, Masingue, Marion, Magy, Laurent, Ghorab, Karima, Rukhadze, Ia, Tsiskaridze, Alexander, Janelidze, Marina, Margania, Temur, Then Bergh, Florian, Hänsel, Eike, Kalb, Andrea, Meilick, Bianca, Reuschel, Mandy, Teußer, Lars-Malte, Unterlauft, Astrid, Goedel, Clemens, Hagenacker, Tim, Totzeck, Andreas, Stolte, Benjamin, Blaes, Franz, Bindler, Christine, Tsoutsikas, Vasilios, Roediger, Annekathrin, Geis, Christian, Schmidt, Jens, Zschüntzsch, Jana, Schwarz, Margret, Meyer, Stefanie, Kummer, Karsten, Glaubitz, Stefanie, Zeng, Rachel, Wiendl, Heinz, Klotz, Luisa, Lammerskitten, Anna, Lünemann, Jan, Diószeghy, Péter, Mantegazza, Renato, Maggi, Lorenzo, Rinaldi, Elena, Gastaldi, Matteo, Mazzacane, Federico, Businaro, Pietro, Iorio, Raffaele, Antonini, Giovanni, Fionda, Laura, Rinaldi, Rita, Rossi, Simone, Habetswallner, Francesco, Tuccillo, Francesco, Umehara, Haruna, Uenaka, Eiko, Takahashi, Masanori, Higashi, Keiko, Kinoshita, Makoto, Yoneda, Emika, Nakamura, Noriko, Fujita, Saeka, Kubota, Tomoya, Ono, Masami, Yamamoto, Sana, Hatano, Taku, Oikoshi, Kazuki, Yokoyama, Kazumasa, Oji, Yutaka, Tomizawa, Yuji, Uzawa, Akiyuki, Yasuda, Manato, Akita, Sachiko, Ozawa, Yukiko, Onishi, Yosuke, Takaki, Miki, Yamada, Hiromi, Minemoto, Kanako, Sanko, Miki, Izawa, Nanae, Nakayama, Mayumi, Masuda, Masayuki, Tsuji, Rune, Ido, Nobuhiro, Hyodo, Yumi, Okubo, Yoshihiko, Minohara, Akiko, Haraguchi, Nana, Naito, Makiko, Yoshida, Seiko, Fukushige, Yuri, Tsujino, Akira, Nagaoka, Atsushi, Miyazaki, Teiichiro, Yoshimura, Shunsuke, Hirayama, Takuro, Shima, Tomoaki, Okamoto, Naoko, Matsumoto, Riki, Sekiguchi, Kenji, Ueda, Takehiro, Chihara, Norio, Kirimura, Mari, Sunagawa, Emi, Suzuki, Ayaka, Suzuki, Shigeaki, Wada, Aozora, Ishizuchi, Kei, Suzuki, Yasushi, Yata, Mitsuo, Komatsu, Yuka, Tsukita, Kenichi, Watanabe, Genya, Sato, Kazuki, Kawasaki, Emiko, Yamamoto, Naoki, Ono, Hirohiko, Tsuda, Tomoko, Ohashi, Shigeki, Utsugisawa, Kimiaki, Fujisawa, Yuka, Yokota, Yumiko, Nagane, Yuriko, Ayumi, Kameda, Takematsu, Yuka, Naito, Hiroyuki, Sugimoto, Takamichi, Kuwada, Kumiko, Rejdak, Konrad, Szklener, Sebastian, Kitowska, Monika, Derkacz, Kandyda, Druzdz, Artur, Berkowicz, Tomasz, Budzinska, Paulina, Halas, Marek, Zaslavskiy, Leonid, Skornyakova, Evgeniya, Kotov, Sergey, Novikova, Ekaterina, Sidorova, Olga, Goldobin, Vitalii, Alekseeva, Tatiana, Isabekova, Patimat, Malkova, Nadezhda, Korobko, Denis, Djordjevic, Gordana, Stojanov, Aleksandar, Peric, Stojan, Lavrnic, Dragana, Bozovic, Ivo, Palibrk, Aleksa, Casasnovas, Carlos, Nedkova-Hristova, Velina, Vidal Fernández, Nuria, Cortés Vicente, Elena, Querol Gutiérrez, Luis, Salvadó Figueras, Maria, Canovas Segura, Anna, Juntas Morales, Raúl, Sanchez Tejerina, Daniel, Saiz, Albert, Blanco Morgado, Yolanda, Llufriú Durán, Sara, Sepúlveda Gázquez, María, Martínez Hernández, Eugenia María, Gutiérrez Gutiérrez, Gerardo, Iniesta, Paqui, Meca Lallana, José, Guo, Yuh-Cherng, Chiu, Hou-Chang, Yeh, Jiann-Horng, Chen, Ya Hui, Lee, Mei Fen, Lee, Yi-Chung, Lai, Kuan Lin, Beydoun, Said, Akhter, Salma, Vu, Tuan, Lam, Lucy, Thomas, Alisha, Rivner, Michael, Quarles, Brandy, Lange, Dale, Holzberg, Shara, Pavlakis, Pantelis, Goutham, Ashwathy, Kaminski, Henry, Aly, Radwa, Ashworth, Lisa, Bender, Kathryn, Bond, Karie, Buckner, Joanne, Byerly, Sara, Caress, James, Clemons, Jessyca, Farmer, Asha, Franklin, Catherine, Harris, Summer, Hiatt, Meredith, Gandhi Mehta, Rachana, Miller, Gina, Smith, Lynn, Smith, Rose, Strittmatter, Brian, Mozaffar, Tahseen, Habib, Ali A, Hernandez, Isela, Moulton, Kelsey, Karam, Chafic, Ravikumar, Pranali, Lomen-Hoerth, Catherine, Rosow, Laura, George, Hannah, Irodenko, Viktoriya, Kang, Min, Denny, Carol, Hanson, Bart, Klein, Sara, Martinez-Thompson, Jennifer, Naddaf, Elie, Padgett, Denny, Sorenson, Eric, L Sultze, Jane, Weis, Delena, Rezania, Kourosh, Thonhoff, Jason, Shroff, Sheetal, Pascuzzi, Robert, Micheels, Angela, Bodkin, Cynthia, Comer, Adam, Baras, Gelasio, Wagner, Renee, Mahuwala, Zabeen, Ryan, Stephen, Su, Kai, Sharma, Khema, Brown, Andrew, Liow, Kore, Drużdż, Artur, Grosskreutz, Julian, Boehnlein, Marion, Bozorg, Ali, Gayfieva, Maryam, Greve, Bernhard, Woltering, Franz, and Kaminski, Henry J

Published
2023
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414. Management of Patients with Advanced Prostate Cancer. Part I: Intermediate-/High-risk and Locally Advanced Disease, Biochemical Relapse, and Side Effects of Hormonal Treatment: Report of the Advanced Prostate Cancer Consensus Conference 2022

Author

Gillessen, Silke, Bossi, Alberto, Davis, Ian D., de Bono, Johann, Fizazi, Karim, James, Nicholas D., Mottet, Nicolas, Shore, Neal, Small, Eric, Smith, Matthew, Sweeney, Christopher, Tombal, Bertrand, Antonarakis, Emmanuel S., Aparicio, Ana M., Armstrong, Andrew J., Attard, Gerhardt, Beer, Tomasz M., Beltran, Himisha, Bjartell, Anders, Blanchard, Pierre, Briganti, Alberto, Bristow, Rob G., Bulbul, Muhammad, Caffo, Orazio, Castellano, Daniel, Castro, Elena, Cheng, Heather H., Chi, Kim N., Chowdhury, Simon, Clarke, Caroline S., Clarke, Noel, Daugaard, Gedske, De Santis, Maria, Duran, Ignacio, Eeles, Ros, Efstathiou, Eleni, Efstathiou, Jason, Ngozi Ekeke, Onyeanunam, Evans, Christopher P., Fanti, Stefano, Feng, Felix Y., Fonteyne, Valerie, Fossati, Nicola, Frydenberg, Mark, George, Daniel, Gleave, Martin, Gravis, Gwenaelle, Halabi, Susan, Heinrich, Daniel, Herrmann, Ken, Higano, Celestia, Hofman, Michael S., Horvath, Lisa G., Hussain, Maha, Jereczek-Fossa, Barbara Alicja, Jones, Robert, Kanesvaran, Ravindran, Kellokumpu-Lehtinen, Pirkko-Liisa, Khauli, Raja B., Klotz, Laurence, Kramer, Gero, Leibowitz, Raya, Logothetis, Christopher J., Mahal, Brandon A., Maluf, Fernando, Mateo, Joaquin, Matheson, David, Mehra, Niven, Merseburger, Axel, Morgans, Alicia K., Morris, Michael J., Mrabti, Hind, Mukherji, Deborah, Murphy, Declan G., Murthy, Vedang, Nguyen, Paul L., Oh, William K., Ost, Piet, O'Sullivan, Joe M., Padhani, Anwar R., Pezaro, Carmel, Poon, Darren M.C., Pritchard, Colin C., Rabah, Danny M., Rathkopf, Dana, Reiter, Robert E., Rubin, Mark. A., Ryan, Charles J., Saad, Fred, Pablo Sade, Juan, Sartor, Oliver A., Scher, Howard I., Sharifi, Nima, Skoneczna, Iwona, Soule, Howard, Spratt, Daniel E., Srinivas, Sandy, Sternberg, Cora N., Steuber, Thomas, Suzuki, Hiroyoshi, Sydes, Matthew R., Taplin, Mary-Ellen, Tilki, Derya, Türkeri, Levent, Turco, Fabio, Uemura, Hiroji, Uemura, Hirotsugu, Ürün, Yüksel, Vale, Claire L., van Oort, Inge, Vapiwala, Neha, Walz, Jochen, Yamoah, Kosj, Ye, Dingwei, Yu, Evan Y., Zapatero, Almudena, Zilli, Thomas, and Omlin, Aurelius

Published
2023
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421. Bryophilous Agaricomycetes (Fungi, Basidiomycota): A Review to Brazil

Author

Furlan-Lopes, Cassiane, primary, Lemos Costa, Alice, additional, de Avila Heberle, Marines, additional, Augusto Bertazzo-Silva, Fernando, additional, Luiza Klotz-Neves, Ana, additional, Rodrigues Ferraz, Kamille, additional, Henrique Mueller, Guilherme, additional, de Souza Falcão, Marina, additional, Renato Pinheiro Velloso, Jorge, additional, and Putzke, Jair, additional

Published
2023
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422. Schlussfolgerung

Author

Gail, Maximilian M., primary, Götz, Georg, additional, Herold, Daniel, additional, Klotz, Phil-Adrian, additional, Lüke, Daniel, additional, Paha, Johannes, additional, and Schäfer, Jan T., additional

Published
2023
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423. Marktversagen und -eingriffe

Author

Gail, Maximilian M., primary, Götz, Georg, additional, Herold, Daniel, additional, Klotz, Phil-Adrian, additional, Lüke, Daniel, additional, Paha, Johannes, additional, and Schäfer, Jan T., additional

Published
2023
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429. Staatliche Eingriffe in die Preisbildung

Author

Gail, Maximilian M., primary, Götz, Georg, additional, Herold, Daniel, additional, Klotz, Phil-Adrian, additional, Lüke, Daniel, additional, Paha, Johannes, additional, and Schäfer, Jan T., additional

Published
2023
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432. Topology in soft and biological matter

Author

Tubiana, L, Alexander, G, Barbensi, A, Buck, D, Cartwright, J, Chwastyk, M, Cieplak, M, Coluzza, I, Čopar, S, Craik, D, Di Stefano, M, Everaers, R, Faísca, P, Ferrari, F, Giacometti, A, Goundaroulis, D, Haglund, E, Hou, Y, Ilieva, N, Jackson, S, Japaridze, A, Kaplan, N, Klotz, A, Li, H, Likos, C, Locatelli, E, López-León, T, Machon, T, Micheletti, C, Michieletto, D, Niemi, A, Niemyska, W, Niewieczerzal, S, Nitti, F, Orlandini, E, Pasquali, S, Perlinska, A, Podgornik, R, Potestio, R, Pugno, N, Ravnik, M, Ricca, R, Rohwer, C, Rosa, A, Smrek, J, Souslov, A, Stasiak, A, Steer, D, Sułkowska, J, Sułkowski, P, Sumners, D, Svaneborg, C, Szymczak, P, Tarenzi, T, Travasso, R, Virnau, P, Vlassopoulos, D, Ziherl, P, Žumer, S, Tubiana L., Alexander G. P., Barbensi A., Buck D., Cartwright J. H. E., Chwastyk M., Cieplak M., Coluzza I., Čopar S., Craik D. J., Di Stefano M., Everaers R., Faísca P. F. N., Ferrari F., Giacometti A., Goundaroulis D., Haglund E., Hou Y. M., Ilieva N., Jackson S. E., Japaridze A., Kaplan N., Klotz A. R., Li H., Likos C. N., Locatelli E., López-León T., Machon T., Micheletti C., Michieletto D., Niemi A., Niemyska W., Niewieczerzal S., Nitti F., Orlandini E., Pasquali S., Perlinska A. P., Podgornik R., Potestio R., Pugno N. M., Ravnik M., Ricca R., Rohwer C. M., Rosa A., Smrek J., Souslov A., Stasiak A., Steer D., Sułkowska J., Sułkowski P., Sumners D. W. L., Svaneborg C., Szymczak P., Tarenzi T., Travasso R., Virnau P., Vlassopoulos D., Ziherl P., Žumer S., Tubiana, L, Alexander, G, Barbensi, A, Buck, D, Cartwright, J, Chwastyk, M, Cieplak, M, Coluzza, I, Čopar, S, Craik, D, Di Stefano, M, Everaers, R, Faísca, P, Ferrari, F, Giacometti, A, Goundaroulis, D, Haglund, E, Hou, Y, Ilieva, N, Jackson, S, Japaridze, A, Kaplan, N, Klotz, A, Li, H, Likos, C, Locatelli, E, López-León, T, Machon, T, Micheletti, C, Michieletto, D, Niemi, A, Niemyska, W, Niewieczerzal, S, Nitti, F, Orlandini, E, Pasquali, S, Perlinska, A, Podgornik, R, Potestio, R, Pugno, N, Ravnik, M, Ricca, R, Rohwer, C, Rosa, A, Smrek, J, Souslov, A, Stasiak, A, Steer, D, Sułkowska, J, Sułkowski, P, Sumners, D, Svaneborg, C, Szymczak, P, Tarenzi, T, Travasso, R, Virnau, P, Vlassopoulos, D, Ziherl, P, Žumer, S, Tubiana L., Alexander G. P., Barbensi A., Buck D., Cartwright J. H. E., Chwastyk M., Cieplak M., Coluzza I., Čopar S., Craik D. J., Di Stefano M., Everaers R., Faísca P. F. N., Ferrari F., Giacometti A., Goundaroulis D., Haglund E., Hou Y. M., Ilieva N., Jackson S. E., Japaridze A., Kaplan N., Klotz A. R., Li H., Likos C. N., Locatelli E., López-León T., Machon T., Micheletti C., Michieletto D., Niemi A., Niemyska W., Niewieczerzal S., Nitti F., Orlandini E., Pasquali S., Perlinska A. P., Podgornik R., Potestio R., Pugno N. M., Ravnik M., Ricca R., Rohwer C. M., Rosa A., Smrek J., Souslov A., Stasiak A., Steer D., Sułkowska J., Sułkowski P., Sumners D. W. L., Svaneborg C., Szymczak P., Tarenzi T., Travasso R., Virnau P., Vlassopoulos D., Ziherl P., and Žumer S.

Abstract

The last years have witnessed remarkable advances in our understanding of the emergence and consequences of topological constraints in biological and soft matter. Examples are abundant in relation to (bio)polymeric systems and range from the characterization of knots in single polymers and proteins to that of whole chromosomes and polymer melts. At the same time, considerable advances have been made in the description of the interplay between topological and physical properties in complex fluids, with the development of techniques that now allow researchers to control the formation of and interaction between defects in diverse classes of liquid crystals. Thanks to technological progress and the integration of experiments with increasingly sophisticated numerical simulations, topological biological and soft matter is a vibrant area of research attracting scientists from a broad range of disciplines. However, owing to the high degree of specialization of modern science, many results have remained confined to their own particular fields, with different jargon making it difficult for researchers to share ideas and work together towards a comprehensive view of the diverse phenomena at play. Compelled by these motivations, here we present a comprehensive overview of topological effects in systems ranging from DNA and genome organization to entangled proteins, polymeric materials, liquid crystals, and theoretical physics, with the intention of reducing the barriers between different fields of soft matter and biophysics. Particular care has been taken in providing a coherent formal introduction to the topological properties of polymers and of continuum materials and in highlighting the underlying common aspects concerning the emergence, characterization, and effects of topological objects in different systems. The second half of the review is dedicated to the presentation of the latest results in selected problems, specifically, the effects of topological constraints on the

Published
2024

440. Onboard Sensor Systems for Automatic Train Operation

Author

Tagiew, Rustam, Leinhos, Dirk, von der Haar, Henrik, Klotz, Christian, Sprute, Dennis, Ziehn, Jens, Schmelter, Andreas, Witte, Stefan, Klasek, Pavel, Filipe, Joaquim, Editorial Board Member, Ghosh, Ashish, Editorial Board Member, Prates, Raquel Oliveira, Editorial Board Member, Zhou, Lizhu, Editorial Board Member, Marrone, Stefano, editor, De Sanctis, Martina, editor, Kocsis, Imre, editor, Adler, Rasmus, editor, Hawkins, Richard, editor, Schleiß, Philipp, editor, Nardone, Roberto, editor, Flammini, Francesco, editor, and Vittorini, Valeria, editor

Published
2022
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449. The Burden of Uncontrolled Cardiovascular Risk Factors in Men With Prostate Cancer: A RADICAL-PC Analysis

Author

Klimis, Harry, Pinthus, Jehonathan H., Aghel, Nazanin, Duceppe, Emmanuelle, Fradet, Vincent, Brown, Ian, Siemens, D. Robert, Shayegan, Bobby, Klotz, Laurence, Luke, Patrick P., Niazi, Tamim, Lavallee, Luke T., Mousavi, Negareh, Hamilton, Robert J., Chin, Joseph L., Gopaul, Darin, Violette, Philippe D., Davis, Margot K., Hanna, Nawar, Sabbagh, Robert, Ben Zadok, Osnat Itzhaki, Hajjar, Ludhmila Abrahão, Kann, Ariel Galapo, Mian, Rajibul, Rangarajan, Sumathy, Huei Ng, Kelvin Kuan, Iakobishvili, Zaza, Selvanayagam, Joseph B., Avezum, Alvaro, and Leong, Darryl P.

Published
2023
Full Text
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