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For proper function of many metabolic processes trace element and mineral intake is important. The objective of this experiment was to evaluate the addition of a dacitic tuff breccia (DTB), a hydrated sodium calcium aluminosilicate, on nursery pig growth and nutrient digestibility. Dietary treatments were: 1) Control (CON) and 2) CON+0.50% DTB (DTB). Pigs (7.73±0.205 kg; 26 d of age) were individually housed and fed for 20d (n=24, 12/trt). Nutrient digestibility was evaluated using individual metabolism pens for 3d total collection of feces and urine during the last week of evaluation. DTB had no effect on pig performance during week 1 (P >0.28). Week 2 ADG (128 versus 302 g/d; P=0.02), BW (10.63 versus 11.77 kg; P=0.03), and G:F (0.275 versus 0.608; P=0.02) were improved for DTB compared to CON fed pigs. Week 3 ADFI was greater for DTB fed pigs compared to CON (642 vs 768 g/d; P=0.01). Overall (d0-20), DTB fed pigs had greater ADG (279 versus 352 g/d; P=0.04), final BW (13.3 versus 14.8 kg; P=0.04), and numerically greater ADFI (497 versus 558 g/d; P=0.16) and G:F (0.562 versus 0.624; P=0.22) compared to CON. During the collection period, ADG was numerically increased (396 versus 427 g/d; P=0.69) and ADFI (544 vs 668 g/d; P=0.03) was greater for DTB versus CON fed pigs. Nutrient digestibility was not affected by inclusion of DTB in the diet (P >0.05). Digestibility coefficients for CON and DTB, respectively, were: 0.863 and 0.856 for DM; 0.842 and 0.842 for digestible energy; 0.824 and 0.814 for nitrogen; 0.701 and 0.667 for phosphorus; 0.873 and 0.816 for sodium; 0.481 and 0.431 for zinc; 0.517 and 0.458 for iron; and 0.438 and 0.392 for manganese. DTB in nursery pig diets improved growth performance and tended to improve feed intake, but had no effect on nutrient digestibility.

Trace element and mineral intake are important for proper function of the immune system and various metabolic processes. The objective of this experiment was to evaluate the effect of a dacitic tuff breccia (DTB), classified as a hydrated sodium calcium aluminosilicate, in the diet of nursery pigs. Dietary treatments were: 1) Control diet (CON), 2) CON + 0.25% DTB (DTB1), and 3) CON + 0.50% DTB (DTB2). Pigs (6.79 + 0.064 kg; 26d of age) were individually housed and fed dietary treatments for 21 d (n=48; 16/trt). At the end of the experiment, blood, jejunal, and ileal samples were collected for a typical metabolic panel and basic histologic and morphologic measurements. DTB2 fed pigs tended (P=0.07) to have greater ADG than CON and DTB1 fed pigs (392, 397, 430g/d for CON, DTB1, DTB2, respectively), and greater (P=0.008) ADFI (591, 592, 669g/d for CON, DTB1, DTB2, respectively). Gain:Feed was not different (P=0.75) among treatments (0.655, 0.663, 0.644 for CON, DTB1, DTB2, respectively). Crypt depth in the jejunum was greater (P=0.04) for DTB1 compared to CON fed pigs but did not differ from DTB2 fed pigs (254.7, 292.0, 275.6mm for CON, DTB1, DTB2, respectively). Villous height, villous:crypt, number of goblet cells and intraepithelial lymphocytes did not differ among treatments in both ileum and jejunum (P >0.17). Total white blood cell (WBC) count did not differ (P >0.10). However, the proportion of WBC that were monocytes was lower (P=0.024) in DTB1 compared to CON and DTB2 fed pigs (1.27, 0.79, 1.45% for CON, DTB1, DTB2, respectively). Blood Urea Nitrogen (BUN) concentration tended (P=0.06) to be linearly decreased with increasing DTB concentrations (9.27, 8.80, 7.75mg/dL). DTB inclusion at 0.5% in nursery pig diets tended to improve growth performance, while inclusion at 0.25% increased jejunal crypt depth and reduced monocytes:WBC and increasing DTB concentrations tended to decreased BUN linearly.

A total of 606 sows (PIC 1050) and their progeny (PIC 1050×280) were used to determine if feeding gestating and lactating sows a proprietary strain of Pichia guilliermondi as a whole-cell inactivated yeast product (WCY; CitriStim, ADM Animal Nutrition, Quincy, IL) improves sow and litter performance in a commercial production system. Once confirmed pregnant at d 35 post-breeding pregnancy check, sows were fed either a basal gestation control (CON) diet (0.55% SID Lysine) or the control diet fortified with 0.15% (1.36 kg/ton) of the WCY replacing corn in the CON diet. Dietary treatments were also fed in lactation (1.05% SID Lysine) once sows were moved into farrowing crates on approximately d 112 of gestation until weaning. Sows supplemented with WCY in gestation and lactation had a greater number of total born piglets by 0.45 pigs (P=0.040), born alive (P< 0.04), heavier born alive litter weight (P< 0.001), and greater post cross-foster litter size (P< 0.001) compared to CON fed sows. Litter size at weaning was increased by 0.54 pigs when sows were fed WCY compared to CON (P< 0.001). However, the average piglet weaning weights from CON fed sows were heavier by 0.35 kg compared to WCY (P< 0.001). This increase in body weight of piglets from CON fed sows is partially explained by their 0.93 days longer lactation (P< 0.001), and may also be due to the smaller litter size nursed throughout lactation. The percent of litters treated for scours decreased from 38.3% to 14.2% when sows were fed WCY (P< 0.001). The distribution of birth weights by body weight range was not different (P=0.2461) between treatments. In conclusion, feeding gestating and lactating sows a proprietary strain of Pichia guilliermondi as a whole-cell inactivated yeast product increased the number of piglets born and number weaned as well as decreased the prevalence of scours during lactation.

In the bone marrow (BM) microenvironment, NG2+/Nestin+ mesenchymal stem cells (MSCs) promote hematopoietic stem cell (HSC) quiescence1,2. Importantly, the BM can also harbour disseminated tumour cells (DTCs) from multiple cancers, which, like HSCs, can remain dormant3. The BM signals are so growth-restrictive that dormant BM DTCs can persist for years to decades only to awaken and fuel lethal metastasis3–10. The mechanisms and niche components regulating DTC dormancy remain largely unknown. Here, we reveal that periarteriolar BM-resident NG2+/Nestin+ MSCs can instruct breast cancer (BC) DTCs to enter dormancy. NG2+/Nestin+ MSCs produce TGFβ2 and BMP7 and activate a quiescence pathway dependent on TGFBRIII and BMPRII, which via p38-kinase result in p27-CDK inhibitor induction. Importantly, genetic depletion of the NG2+/Nestin+ MSCs or conditional knock-out of TGFβ2 in the NG2+/Nestin+ MSCs led to awakening and bone metastatic expansion of otherwise dormant p27+/Ki67− DTCs. Our results provide a direct proof that HSC dormancy niches control BC DTC dormancy. Given that aged NG2+/Nestin+ MSCs can lose homeostatic control of HSC dormancy, our results suggest that aging or extrinsic factors that affect the NG2+/Nestin+ MSC niche may result in a break from dormancy and BC bone relapse.

ObjectivesTo evaluate parent and teacher opinion of the provision of in-school eyecare and jargon-free written reporting of visual status for children in special educational settings.Participants and methodsA nationally-agreed, in-school eyecare framework for children attending special schools which recommends a full eye examination, dispensing of spectacles and provision of a jargon-free written report of visual outcomes to parents and teachers, was provided to 200 children (mean age 10 years, 9 months; 70% male) attending a special school in the UK. The written 'Vision Report' detailed, in lay-language, results from the eye examination and provided practical advice to alleviate the impact of vision difficulties both at home and in the classroom. Following implementation of the framework, parents and teachers completed a feedback questionnaire to determine their opinion of the in-school eye examination and utility of the Vision Report.ResultsParents of 123 participants returned a feedback questionnaire. Eighty-eight participants were represented by the 23 teachers who returned a questionnaire. The in-school eyecare was rated positively for children in special education by 82.4% of parents and 80.9% of teachers. Key benefits included the familiarity of the in-school setting (81.3% of parents and 100% of teachers agree), the convenience of the setting for parents (74.0% of parents and 100% of teachers agree), and the opportunity for teachers to speak directly to eyecare providers regarding a child's visual needs (82.6% of teachers agree). The information provided by the Vision Report was deemed useful day-to-day by 78.3% of parents and 100% of teachers. The majority (80%) of teachers implemented classroom modifications suggested in the report, whereas only 47.9% of parents reported implementation of modifications at home.ConclusionsProvision of in-school eyecare is valued by parents and teachers of children in special education settings. Jargon-free, written reports of visual status are valued and utilised by parents and teachers. Further support is required to aid parents in implementing vision modifications at home.

Dante Gabriel Rossetti stopped exhibiting after the 1850s and relied on commissions for paintings and their replicas from then on. This chapter discusses Rossetti’s modes of autograph replica production, his rhetorical promotion of his replicas, his patrons’ desire for them, his attitudes toward replication and his relationships with selected patrons who eagerly commissioned replicas: London solicitor Leonard Valpy, Liverpool shipping magnate Frederick Leyland, Glasgow and Liverpool cotton and wine merchant William Graham, and Birkenhead banker George Rae and his wife Julia. Rossetti’s replication production was part of his larger practice of continuously revising his works, whether singular or replicated paintings. Rossetti’s patrons had different motives and perspectives on his art—Graham’s religious projection, Leyland’s specification of size and subject, the Raes’ aestheticist pleasures, Valpy’s prudishness and volatility. American collectors believed European art would raise public taste and inspire future artists, and with these motives they were eager to own works by celebrity artists like Rossetti.

A steady increase in wildfire event severity and season length has led to greater potential for exposure to fine particulate matter associated with wildfire smoke. Research has found fine particulate matter to be correlated with a myriad of health ailments and thus effective strategies for controlling exposures are needed. In this study, a correction factor associated with wildfire-sourced fine particulate matter was established for a TSI SidePak AM520 by conducting sampling with a co-located MetOne BAM 1020. Portable air cleaner efficacy was assessed by simultaneously measuring PM

Objectives To evaluate parent and teacher opinion of the provision of in-school eyecare and jargon-free written reporting of visual status for children in special educational settings. Participants and methods A nationally-agreed, in-school eyecare framework for children attending special schools which recommends a full eye examination, dispensing of spectacles and provision of a jargon-free written report of visual outcomes to parents and teachers, was provided to 200 children (mean age 10 years, 9 months; 70% male) attending a special school in the UK. The written ‘Vision Report’ detailed, in lay-language, results from the eye examination and provided practical advice to alleviate the impact of vision difficulties both at home and in the classroom. Following implementation of the framework, parents and teachers completed a feedback questionnaire to determine their opinion of the in-school eye examination and utility of the Vision Report. Results Parents of 123 participants returned a feedback questionnaire. Eighty-eight participants were represented by the 23 teachers who returned a questionnaire. The in-school eyecare was rated positively for children in special education by 82.4% of parents and 80.9% of teachers. Key benefits included the familiarity of the in-school setting (81.3% of parents and 100% of teachers agree), the convenience of the setting for parents (74.0% of parents and 100% of teachers agree), and the opportunity for teachers to speak directly to eyecare providers regarding a child’s visual needs (82.6% of teachers agree). The information provided by the Vision Report was deemed useful day-to-day by 78.3% of parents and 100% of teachers. The majority (80%) of teachers implemented classroom modifications suggested in the report, whereas only 47.9% of parents reported implementation of modifications at home. Conclusions Provision of in-school eyecare is valued by parents and teachers of children in special education settings. Jargon-free, written reports of visual status are valued and utilised by parents and teachers. Further support is required to aid parents in implementing vision modifications at home.

Purpose: Interprofessional collaboration is recognized as a healthcare practice paradigm that may decrease overall costs and minimize errors. Yet it remains common for practitioners to provide care within silos, inadequately considering the impact of their decisions on other providers and overall costs, which ultimately may negatively impact the patient. Integrating interprofessional collaboration in school curricula can establish the importance of this approach to healthcare. For optimal efficacy, every professional in the healthcare team must recognize their unique role and the roles of others, to allow for seamless interprofessional collaboration. Simulation is a teaching tool that provides students with the opportunity to experience and reflect upon their responses to real-world clinical encounters in an environment that is safe to them and to patients. The purpose of this pilot study was to investigate the effect of interprofessional simulation on occupational therapy and physical therapy students’ role clarity and perceived readiness for collaborative practice. Method: A mixed methods study design was used with occupational and physical therapy students matriculated in the same college. Two surveys were given to the participants pre- and post-interprofessional simulation: the Readiness for Interprofessional Learning Scale (RIPLS; evaluates student readiness for interprofessional learning) and the Interdisciplinary Education Perception Scale (IEPS; evaluates student perceptions of interprofessional training). Focus groups followed the interprofessional simulation to explore the subjects’ experience. Results: Statistically significant changes were noted in the RIPLS pre-post simulation. Five themes emerged from the focus groups including: students value simulation; students value interprofessional education; interprofessional experience facilitates an understanding of role clarity; teamwork has value and challenges; and, students value providing patient centered care. Conclusion: Simulation is a teaching resource that may prepare occupational therapy and physical therapy students for interprofessional collaboration in patient care. The results of this study can inform interprofessional curricular development for both occupational therapy and physical therapy programs.

Background There has been a growing interest in the application of gamification (ie, the use of game elements) to computerized cognitive training. The introduction of targeted gamification features to such tasks may increase motivation and engagement as well as improve intervention effects. However, it is possible that game elements can also have adverse effects on cognitive training (eg, be a distraction), which can outweigh their potential motivational benefits. So far, little is known about the effectiveness of such applications. Objective This study aims to conduct a systematic review and meta-analysis to investigate the effect of gamification on process outcomes (eg, motivation) and on changes in the training domain (eg, cognition), as well as to explore the role of potential moderators. Methods We searched PsycINFO, Cumulative Index to Nursing and Allied Health Literature, ProQuest Psychology, Web of Science, Scopus, PubMed, Science Direct, Excerpta Medica dataBASE, Institute of Electrical and Electronics Engineers Xplore, Association for Computing Machinery, and a range of gray-area literature databases. The searches included papers published between 2008 and 2018. Meta-analyses were performed using a random-effects model. Results The systematic review identified 49 studies, of which 9 randomized controlled trials were included in the meta-analysis. The results of the review indicated that research in this context is still developing and lacks well-controlled empirical studies. Gamification in cognitive training is applied to a large range of age groups and audiences and is mostly delivered at a research site through computers. Rewards and feedback continue to dominate the gamification landscape, whereas social-oriented features (eg, competition) are underused. The meta-analyses showed that gamified training tasks were more motivating/engaging (Hedges g=0.72) and more demanding/difficult (Hedges g=–0.52) than non- or less-gamified tasks, whereas no effects on the training domain were found. Furthermore, no variables moderated the impact of gamified training tasks. However, meta-analytic findings were limited due to a small number of studies. Conclusions Overall, this review provides an overview of the existing research in the domain and provides evidence for the effectiveness of gamification in improving motivation/engagement in the context of cognitive training. We discuss the shortcomings in the current literature and provide recommendations for future research.

Evaluation and control of respirable crystalline silica (RCS) exposures are critical components of an effective mine industrial hygiene program. To provide more timely exposure data in the field, an end-of-shift Fourier transform infrared (FT-IR) spectrometry method has been developed for evaluation of direct-on-filter RCS. The present study aimed to apply this FT-IR method using field samples collected in three Northwestern U.S. metal/nonmetal mines and compare the results to traditional laboratory X-ray diffraction analysis (XRD). Seventy-five dust samples were analyzed using both methods. Samples for each mine were split in half by random assignment, with half used to create a calibration factor for the FT-IR analysis and half used to apply the calibration. Nonparametric correlational and two-sample comparative tests were used to assess the strength of association and the level of agreement between the two methods. Strong, positive correlations were observed between FT-IR and XRD RCS concentrations, with Spearman rank correlation coefficients ranging between 0.84 and 0.97. The mean RCS concentrations determined through FT-IR analysis were lower than through XRD analysis, with mean differences ranging from —4 to —133 ug/m3 and mean percent errors ranging from 12% to 28%. There was a statistically significant improvement in the level of agreement between log FT-IR and log XRD RCS concentrations following calibration at two of the three mines, with mean differences of —0.03 (p = 0.002) and —0.02 (p = 0.044) in the log scale. The reduction in mean difference following calibration at the other mine was not statistically significant (mean log scale difference = —0.05, p = 0.215), but the differences between FT-IR and XRD were not significantly different without calibration (mean log scale difference = —0.07, p = 0.534). The results indicate that mine-specific calibration factors can improve the level of agreement between RCS concentrations determined via a field-based, end-of-shift FT-IR method in metal/non-metal mines as compared to traditional XRD analysis.