2,866 results on '"Imbert, P"'
Search Results
402. Combined intra- and extra-articular grafting for revision ACL reconstruction: A multicentre study by the French Arthroscopy Society (SFA)
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Louis, M.-L., D’ingrado, P., Ehkirch, F.P., Bertiaux, S., Colombet, P., Sonnery-Cottet, B., Schlatterer, B., Pailhé, R., Panisset, J.C., Steltzlen, C., Lustig, S., Lutz, C., Dalmay, F., Imbert, P., and Saragaglia, D.
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- 2017
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403. High-quality brain perfusion SPECT images may be achieved with a high-speed recording using 360° CZT camera
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Bordonne, Manon, Chawki, Mohammad B., Marie, Pierre-Yves, Zaragori, Timothée, Roch, Véronique, Grignon, Rachel, Imbert, Laetitia, and Verger, Antoine
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- 2020
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404. Association between Neu5Gc carbohydrate and serum antibodies against it provides the molecular link to cancer: French NutriNet-Santé study
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Bashir, Salam, Fezeu, Leopold K., Leviatan Ben-Arye, Shani, Yehuda, Sharon, Reuven, Eliran Moshe, Szabo de Edelenyi, Fabien, Fellah-Hebia, Imen, Le Tourneau, Thierry, Imbert-Marcille, Berthe Marie, Drouet, Emmanuel B., Touvier, Mathilde, Roussel, Jean-Christian, Yu, Hai, Chen, Xi, Hercberg, Serge, Cozzi, Emanuele, Soulillou, Jean-Paul, Galan, Pilar, and Padler-Karavani, Vered
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- 2020
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405. Single Circulating Fetal Trophoblastic Cells Eligible for Non Invasive Prenatal Diagnosis: the Exception Rather than the Rule
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Cayrefourcq, Laure, Vincent, Marie-Claire, Pierredon, Sandra, Moutou, Céline, Imbert-Bouteille, Marion, Haquet, Emmanuelle, Puechberty, Jacques, Willems, Marjolaine, Liautard-Haag, Cathy, Molinari, Nicolas, Zordan, Cécile, Dorian, Virginie, Rooryck-Thambo, Caroline, Goizet, Cyril, Chaussenot, Annabelle, Rouzier, Cécile, Boureau-Wirth, Amandine, Monteil, Laetitia, Calvas, Patrick, Miry, Claire, Favre, Romain, Petrov, Yuliya, Khau Van Kien, Philippe, Le Boette, Elsa, Fradin, Mélanie, Alix-Panabières, Catherine, and Guissart, Claire
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- 2020
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406. Impact of fecal microbiota transplantation on chronic recurrent pouchitis in ulcerative colitis with ileo-anal anastomosis: study protocol for a prospective, multicenter, double-blind, randomized, controlled trial
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Trang-Poisson, Caroline, Kerdreux, Elise, Poinas, Alexandra, Planche, Lucie, Sokol, Harry, Bemer, Pascale, Cabanas, Karine, Hivernaud, Eliane, Biron, Laetitia, Flet, Laurent, Montassier, Emmanuel, Le Garcasson, Ghislaine, Chiffoleau, Anne, Jobert, Alexandra, Lepelletier, Didier, Caillon, Jocelyne, Le Pape, Patrice, Imbert, Berthe-Marie, and Bourreille, Arnaud
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- 2020
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407. Use of static and dynamic [18F]-F-DOPA PET parameters for detecting patients with glioma recurrence or progression
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Zaragori, Timothée, Ginet, Merwan, Marie, Pierre-Yves, Roch, Véronique, Grignon, Rachel, Gauchotte, Guillaume, Rech, Fabien, Blonski, Marie, Lamiral, Zohra, Taillandier, Luc, Imbert, Laëtitia, and Verger, Antoine
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- 2020
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408. A multimodal and signals fusion approach for assessing the impact of stressful events on Air Traffic Controllers
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Borghini, Gianluca, Di Flumeri, Gianluca, Aricò, Pietro, Sciaraffa, Nicolina, Bonelli, Stefano, Ragosta, Martina, Tomasello, Paola, Drogoul, Fabrice, Turhan, Uğur, Acikel, Birsen, Ozan, Ali, Imbert, Jean Paul, Granger, Géraud, Benhacene, Railane, and Babiloni, Fabio
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- 2020
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409. Monte Carlo simulation of digital photon counting PET
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Salvadori, Julien, Labour, Joey, Odille, Freddy, Marie, Pierre-Yves, Badel, Jean-Noël, Imbert, Laëtitia, and Sarrut, David
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- 2020
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410. Timing and original features of flagellum assembly in trypanosomes during development in the tsetse fly
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Lemos, Moara, Mallet, Adeline, Bertiaux, Eloïse, Imbert, Albane, Rotureau, Brice, and Bastin, Philippe
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- 2020
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411. Head-to-head comparison between digital and analog PET of human and phantom images when optimized for maximizing the signal-to-noise ratio from small lesions
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Salvadori, Julien, Odille, Freddy, Verger, Antoine, Olivier, Pierre, Karcher, Gilles, Marie, Pierre-Yves, and Imbert, Laetitia
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- 2020
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412. Resistance of melanoma to immune checkpoint inhibitors is overcome by targeting the sphingosine kinase-1
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Imbert, Caroline, Montfort, Anne, Fraisse, Marine, Marcheteau, Elie, Gilhodes, Julia, Martin, Elodie, Bertrand, Florie, Marcellin, Marlène, Burlet-Schiltz, Odile, Peredo, Anne Gonzalez de, Garcia, Virginie, Carpentier, Stéphane, Tartare-Deckert, Sophie, Brousset, Pierre, Rochaix, Philippe, Puisset, Florent, Filleron, Thomas, Meyer, Nicolas, Lamant, Laurence, Levade, Thierry, Ségui, Bruno, Andrieu-Abadie, Nathalie, and Colacios, Céline
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- 2020
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413. Relevance of Dynamic 18F-DOPA PET Radiomics for Differentiation of High-Grade Glioma Progression from Treatment-Related Changes
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Shamimeh Ahrari, Timothée Zaragori, Laura Rozenblum, Julien Oster, Laëtitia Imbert, Aurélie Kas, and Antoine Verger
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DOPA PET ,glioma ,recurrence ,dynamic ,radiomics ,Biology (General) ,QH301-705.5 - Abstract
This study evaluates the relevance of 18F-DOPA PET static and dynamic radiomics for differentiation of high-grade glioma (HGG) progression from treatment-related changes (TRC) by comparing diagnostic performances to the current PET imaging standard of care. Eighty-five patients with histologically confirmed HGG and investigated by dynamic 18F-FDOPA PET in two institutions were retrospectively selected. ElasticNet logistic regression, Random Forest and XGBoost machine models were trained with different sets of features—radiomics extracted from static tumor-to-background-ratio (TBR) parametric images, radiomics extracted from time-to-peak (TTP) parametric images, as well as combination of both—in order to discriminate glioma progression from TRC at 6 months from the PET scan. Diagnostic performances of the models were compared to a logistic regression model with TBRmean ± clinical features used as reference. Training was performed on data from the first center, while external validation was performed on data from the second center. Best radiomics models showed only slightly better performances than the reference model (respective AUCs of 0.834 vs. 0.792, p < 0.001). Our current results show similar findings at the multicentric level using different machine learning models and report a marginal additional value for TBR static and TTP dynamic radiomics over the classical analysis based on TBR values.
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- 2021
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414. Review of saturation decompression procedures used in commercial diving.
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Imbert, Jean-Pierre, Matity, Lyubisa, Massimelli, Jean-Yves, and Bryson, Philip
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Introduction: This is a review of commercial heliox saturation decompression procedures. The scope does not include compression, storage depth or bell excursion dive procedures. The objectives are to: identify the sources of the procedures; trace their evolution; describe the current practice; and detect relevant trends. Methods: Eleven international commercial diving companies provided their diving manuals for review under a confidentiality agreement. Results: Modern commercial diving saturation procedures are derived from a small number of original procedures (United States Navy, Comex, and NORSOK). In the absence of relevant scientific studies since the late 80's, the companies have empirically adapted these procedures according to their needs and experience. Such adaptation has caused differences in decompression rates shallower than 60 msw, decompression rest stops and the decision to decompress linearly or stepwise. Nevertheless, the decompression procedures present a remarkable homogeneity in chamber PO2 and daily decompression rates when deeper than 60 msw. The companies have also developed common rules of good practice; no final decompression should start with an initial ascending excursion; a minimum hold is required before starting a final decompression after an excursion dive. Recommendation is made for the divers to exercise during decompression. Conclusions: We observed a trend towards harmonisation within the companies that enforce international procedures, and, between companies through cooperation inside the committees of the industry associations. [ABSTRACT FROM AUTHOR]
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- 2024
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415. The effect of voxel and field of view size on the volumetric alteration artifact of high-density materials with 2 cone beam computed tomography devices.
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Lucca, Luiza Valdemarca, Cascante-Sequeira, Deivi, Coelho-Silva, Fernanda, Ruiz-Imbert, Ana Cecilia, Freitas, Deborah Queiroz, Haiter-Neto, Francisco, and de-Azevedo-Vaz, Sergio Lins
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We investigated the influence of voxel and field of view (FOV) sizes on expression of the volumetric alteration artifact (VAA) of 5 high-density materials in 2 cone beam computed tomography (CBCT) devices. Cylinders of amalgam, cobalt-chromium, gutta-percha, titanium, and zirconium were individually positioned in a polymethyl methacrylate phantom. OP300 Maxio and ProMax 3D Classic CBCT devices were used to acquire images with varying voxel and FOV sizes, totaling 585 scans. Two evaluators segmented the high-density cylinder images to obtain the tomographic volumes. The difference between the tomographic and physical volume of each cylinder (i.e., volumetric alteration) was calculated. Statistical analysis was conducted with multiway ANOVA and the Tukey post hoc test (α = 5%). Evaluator reliability was measured with the intraclass correlation coefficient (ICC). All studied parameters and nearly all interactions influenced the VAA (P <.05). The post hoc test demonstrated less volumetric alteration for the smallest voxel sizes, 61 × 78 mm FOV, and gutta-percha for OP300, and for the smallest voxel sizes, 80 × 80 mm FOV, and gutta-percha and titanium for ProMax 3D (P <.05). The ICC demonstrated perfect reliability (1.00). Voxel and FOV sizes influenced VAA expression. Using smaller voxel sizes, the 61 × 78 mm FOV for OP300 and the 80 × 80 mm FOV for ProMax 3D, and materials with lower density and lower atomic number reduced VAA expression. [ABSTRACT FROM AUTHOR]
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- 2024
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416. Association of BTN2A1+ microvesicles with overall survival and the role of γδ T cells as a potential therapeutic target in patients with hormone-sensitive metastatic prostate cancer.
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Billon, Emilien, Imbert, Caroline, Gorvel, Laurent, Richaud, Manon, Ghossoub, Rania, Girault, Virginie, Fest, Thierry, Gravis, Gwenaelle, and Olive, Daniel
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- 2024
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417. La grève des cheminots éthiopiens en 1949 : d'une domination, l'autre.
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Imbert-Vier, Simon
- Abstract
Copyright of Mouvement Social is the property of Presses de Sciences Po and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2024
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418. Liderazgo distribuido: plan de mejora para revertir la desvinculación en formación de profesorado.
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Silva Sánchez, Valeria Susana and Imbert Romero, Nelky Daisy
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TRAINING of student teachers ,CASE method (Teaching) ,SCHOOL dropouts ,EDUCATION research ,EDUCATIONAL leadership ,STUDENT participation - Abstract
Copyright of Páginas de la Educación is the property of Universidad Catolica del Uruguay Damaso Antonio Larranaga and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2024
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419. Addressing Human Skin Ethnicity: Contribution of Tissue Engineering to the Development of Cosmetic Ingredients
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Christophe Capallere, Marianne Arcioni, Laura Restellini, and Isabelle Imbert
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ethnic skin ,reconstructed human pigmented epidermis ,acne ,pollution ,dry skin ,PIH ,Chemistry ,QD1-999 - Abstract
Recent publications describe various skin disorders in relation to phototypes and aging. The highest phototypes (III to VI) are more sensitive to acne, with the appearance of dark spots due to the inflammation induced by Cutibacterium acnes (previously Propionibacterium acnes). Dryness with aging is due to a lower activity of specific enzymes involved in the maturation of lipids in the stratum corneum. To observe and understand these cutaneous issues, tissue engineering is a perfect tool. Since several years, pigmented epidermis with melanocytes derived from specific phototypes allow to develop in vitro models for biological investigations. In the present study, several models were developed to study various skin disorders associated with phototypes and aging. These models were also used to evaluate selected ingredients’ ability to decrease the negative effects of acne, inflammation, and cutaneous dryness. Hyperpigmentation was observed on our reconstructed pigmented epidermis after the application of C. acnes, and pollutant (PM10) application induced increased inflammatory cytokine release. Tissue engineering and molecular biology offer the capability to modify genetically cells to decrease the expression of targeted proteins. In our case, GCase was silenced to decrease the maturation of lipids and in turn modify the epidermal barrier function. These in vitro models assisted in the development of ethnic skin-focused cosmetic ingredients.
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- 2021
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420. Absence of zero field muon spin relaxation induced by superconductivity in the B phase of UPt$_3$
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de Réotier, P. Dalmas, Huxley, A., Yaouanc, A., Flouquet, J., Bonville, P., Imbert, P., Pari, P., Gubbens, P. C. M., and Mulders, A. M.
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Condensed Matter - Abstract
We present muon spin relaxation measurements performed on crystals of the heavy fermion superconductor UPt$_3$. In zero applied field, contrary to a previous report, we do not observe an increase of the internal magnetic field in the lower superconducting phase (the B phase). Our result gives an experimental upper bound of the magnetic field that could be associated with the superconducting state., Comment: 4 pages, REVTeX 3.0, 2 PostScript figures
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- 1995
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421. Proposed volume-based methods for correcting the shift in left ventricular ejection fraction from blood-pool gated SPECT
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Marie, Pierre-Yves and Imbert, Laetitia
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- 2019
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422. Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study
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Reyes, L, Murthy, S, Garcia-Gallo, E, Merson, L, Ibanez-Prada, E, Rello, J, Fuentes, Y, Martin-Loeches, I, Bozza, F, Duque, S, Taccone, F, Fowler, R, Kartsonaki, C, Goncalves, B, Citarella, B, Aryal, D, Burhan, E, Cummings, M, Delmas, C, Diaz, R, Figueiredo-Mello, C, Hashmi, M, Panda, P, Jimenez, M, Rincon, D, Thomson, D, Nichol, A, Marshall, J, Olliaro, P, Abbas, A, Abdukahil, S, Abe, R, Abel, L, Absil, L, Acharya, S, Acker, A, Adriao, D, Al Ageel, S, Ahmed, S, Ainscough, K, Aisa, T, Hssain, A, Tamlihat, Y, Akimoto, T, Akmal, E, Al Qasim, E, Alalqam, R, Al-dabbous, T, Alegesan, S, Alegre, C, Alessi, M, Alex, B, Alexandre, K, Al-Fares, A, Alfoudri, H, Ali, I, Shah, N, Alidjnou, K, Aliudin, J, Alkhafajee, Q, Allavena, C, Allou, N, Altaf, A, Alves, J, Alves, R, Cabrita, J, Amaral, M, Ampaw, P, Andini, R, Andrejak, C, Angheben, A, Angoulvant, F, Ansart, S, Antonelli, M, de Brito, C, Apriyana, A, Arabi, Y, Aragao, I, Araujo, C, Arcadipane, A, Archambault, P, Arenz, L, Arlet, J, Arnold-Day, C, Arora, L, Arora, R, Artaud-Macari, E, Asensio, A, Asif, N, Asim, M, Assie, J, Atique, A, Attanyake, A, Auchabie, J, Aumaitre, H, Auvet, A, Azemar, L, Azoulay, C, Bach, B, Bachelet, D, Badr, C, Baig, N, Baillie, J, Bak, E, Bakakos, A, Bal, A, Balan, V, Bani-Sadr, F, Barbalho, R, Barclay, W, Barnikel, M, Barrasa, H, Barrelet, A, Barrigoto, C, Bartoli, M, Baruch, J, Basmaci, R, Battaglini, D, Bauer, J, Dow, D, Beane, A, Bedossa, A, Begum, H, Behilill, S, Beishuizen, A, Beljantsev, A, Bellemare, D, Beltrame, A, Beluze, M, Benech, N, Benkerrou, D, Bennett, S, Bento, L, Berdal, J, Bergeaud, D, Bergin, H, Sobrino, J, Bertoli, G, Bertolino, L, Bessis, S, Bevilcaqua, S, Bezulier, K, Bhatt, A, Bhavsar, K, Bianco, C, Singh, M, Humaid, F, Bissuel, F, Bitker, L, Bitton, J, Blanco-Schweizer, P, Blier, C, Bloos, F, Blot, M, Boccia, F, Bodenes, L, Bogaert, D, Boivin, A, Bolze, P, Bompart, F, Borges, D, Borie, R, Bosse, H, Botelho-Nevers, E, Bouadma, L, Bouchaud, O, Bouchez, S, Bouhmani, D, Bouhour, D, Bouiller, K, Bouillet, L, Bouisse, C, Boureau, A, Bourke, J, Bouscambert, M, Bousquet, A, Bouziotis, J, Boxma, B, Boyer-Besseyre, M, Boylan, M, Braconnier, A, Braga, C, Brandenburger, T, Monteiro, F, Brazzi, L, Breen, D, Breen, P, Brickell, K, Browne, A, Browne, S, Brusse-Keizer, M, Buchtele, N, Buesaquillo, C, Bugaeva, P, Buisson, M, Burrell, A, Bustos, I, Butnaru, D, Cabie, A, Cabral, S, Caceres, E, Cadoz, C, Garces, R, Calligy, K, Calvache, J, Camoes, J, Campana, V, Campbell, P, Canepa, C, Cantero, M, Caraux-Paz, P, Carcel, S, Cardellino, C, Cardoso, F, Cardoso, N, Cardoso, S, Carelli, S, Carlier, N, Carmoi, T, Carney, G, Carqueja, I, Carret, M, Carrier, F, Carroll, I, Carson, G, Casanova, M, Cascao, M, Casey, S, Casimiro, J, Cassandra, B, Castaneda, S, Castanheira, N, Castor-Alexandre, G, Castrillon, H, Castro, I, Catarino, A, Catherine, F, Cattaneo, P, Cavalin, R, Cavalli, G, Cavayas, A, Ceccato, A, Cervantes-Gonzalez, M, Chair, A, Chakveatze, C, Chan, A, Chand, M, Auger, C, Chapplain, J, Chas, J, Chaudry, M, Iniguez, J, Chen, A, Chen, Y, Cheng, M, Cheret, A, Chiarabini, T, Chica, J, Chirouze, C, Chiumello, D, Cho, S, Cholley, B, Chopin, M, Cidade, J, Herreros, J, Ciullo, A, Clarke, E, Clarke, J, Clohisey, S, Cobb, P, Codan, C, Cody, C, Coelho, A, Coles, M, Colin, G, Collins, M, Colombo, S, Combs, P, Connor, M, Conrad, A, Contreras, S, Conway, E, Cooke, G, Copland, M, Cordel, H, Corley, A, Cornelis, S, Cornet, A, Corpuz, A, Cortegiani, A, Corvaisier, G, Costigan, E, Couffignal, C, Couffin-Cadiergues, S, Courtois, R, Cousse, S, Cregan, R, Croonen, S, Crowl, G, Crump, J, Cruz, C, Bermudez, J, Rojo, J, Csete, M, Cullen, A, Curley, G, Curlier, E, Curran, C, Custodio, P, da Silva Filipe, A, Da Silveira, C, Dabaliz, A, Dagens, A, Dahly, D, Dalton, H, Dalton, J, Daly, S, Damas, J, Daneman, N, Daniel, C, Dankwa, E, Dantas, J, D'Aragon, F, de Loughry, G, de Mendoza, D, De Montmollin, E, de Oliveira Franca, R, de Pinho Oliveira, A, De Rosa, R, de Silva, T, de Vries, P, Deacon, J, Dean, D, Debard, A, Debray, M, Decastro, N, Dechert, W, Deconninck, L, Decours, R, Defous, E, Delacroix, I, Delaveuve, E, Delavigne, K, Dell'Amore, A, Delobel, P, Delsing, C, Demonchy, E, Denis, E, Deplanque, D, Depuydt, P, Descamps, D, Desvallees, M, Dewayanti, S, Dhanger, P, Diallo, A, Diamantis, S, Dias, A, Diaz, J, Diaz, P, Didier, K, Diehl, J, Dieperink, W, Dimet, J, Dinot, V, Diop, F, Diouf, A, Dishon, Y, Djossou, F, Docherty, A, Doherty, H, Dondorp, A, Donnelly, C, Donnelly, M, Donohue, C, Donohue, S, Donohue, Y, Doran, P, Dorival, C, D'Ortenzio, E, Douglas, J, Dournon, N, Downer, T, Downey, J, Downing, M, Drake, T, Driscoll, A, Fonseca, C, Dubee, V, Dubos, F, Ducancelle, A, Dudman, S, Dunand, P, Dunning, J, Duplaix, M, Durante-Mangoni, E, Durham, L, Dussol, B, Duthoit, J, Duval, X, Dyrhol-Riise, A, Echeverria-Villalobos, M, Egan, S, Eira, C, Sanharawi, M, Elapavaluru, S, Elharrar, B, Ellerbroek, J, Eloy, P, Elshazly, T, Enderle, I, Endo, T, Engelmann, I, Enouf, V, Epaulard, O, Escher, M, Esperatti, M, Esperou, H, Santo, C, Esposito-Farese, M, Estevao, J, Etienne, M, Ettalhaoui, N, Everding, A, Evers, M, Fabre, I, Fabre, M, Faheem, A, Fahy, A, Fairfield, C, Fakar, Z, Fareed, K, Faria, P, Farooq, A, Fatoni, A, Faure, K, Favory, R, Fayed, M, Feely, N, Feeney, L, Fernandes, J, Fernandes, M, Fernandes, S, Ferrand, F, Devouge, E, Ferrao, J, Ferraz, M, Ferreira, B, Ferreira, I, Ferreira, S, Ferrer-Roca, R, Ferriere, N, Ficko, C, Fiorda, J, Flament, T, Flateau, C, Fletcher, T, Florio, L, Flynn, D, Foley, C, Foley, J, Fomin, V, Fonseca, T, Fontela, P, Forsyth, S, Foster, D, Foti, G, Fourn, E, Fraher, M, Franch-Llasat, D, Fraser, C, Fraser, J, Freire, M, Ribeiro, A, French, C, Friedrich, C, Fry, S, Fuentes, N, Fukuda, M, Argin, G, Gaborieau, V, Gaci, R, Gagliardi, M, Gagnard, J, Gagneux-Brunon, A, Gaiao, S, Skeie, L, Gallagher, P, Gamble, C, Garan, A, Garcia, R, Barrio, N, Garimella, N, Garot, D, Garrait, V, Gauli, B, Gault, N, Gavin, A, Gavrylov, A, Gaymard, A, Gebauer, J, Geraud, E, Morlaes, L, Germano, N, Ghosn, J, Giani, M, Gibson, J, Gigante, T, Gilg, M, Gilroy, E, Giordano, G, Girvan, M, Gissot, V, Glikman, D, Glybochko, P, Gnall, E, Goco, G, Goehringer, F, Goepel, S, Goffard, J, Golob, J, Gomez-Junyent, J, Gominet, M, Gonzalez, A, Gordon, P, Gorenne, I, Goubert, L, Goujard, C, Goulenok, T, Grable, M, Graf, J, Grandin, E, Granier, P, Grasselli, G, Green, C, Greene, C, Greenhalf, W, Greffe, S, Grieco, D, Griffee, M, Griffiths, F, Groenendijk, A, Lordemann, A, Gruner, H, Gu, Y, Guedj, J, Guego, M, Guellec, D, Guerguerian, A, Guerreiro, D, Guery, R, Guillaumot, A, Guilleminault, L, de Castro, M, Guimard, T, Haalboom, M, Haber, D, Habraken, H, Hachemi, A, Hadri, N, Haidri, F, Hakak, S, Hall, A, Hall, M, Halpin, S, Hameed, J, Hamer, A, Hamidfar, R, Hammond, T, Haniffa, R, Hardwick, H, Harrison, E, Harrison, J, Harrison, S, Hasan, M, Hashmi, J, Hayat, M, Hayes, A, Hays, L, Heerman, J, Heggelund, L, Hendry, R, Hennessy, M, Hentzien, M, Hershey, A, Hesstvedt, L, Hidayah, A, Higgins, D, Higgins, E, Higgins, R, Hinchion, R, Hinton, S, Hitoto, H, Ho, A, Hoctin, A, Hoffmann, I, Hoiting, O, Holt, R, Holter, J, Horby, P, Horcajada, J, Hoshino, K, Houas, I, Hough, C, Hsu, J, Hulot, J, Huo, S, Hurd, A, Hussain, I, Ijaz, S, Ikram, A, Illes, H, Imbert, P, Imran, M, Sikander, R, Imtiaz, A, Inacio, H, Dominguez, C, Ippolito, M, Isgett, S, Isidoro, T, Isnard, M, Ivulich, D, Jaafar, D, Jaafoura, S, Jabot, J, Jackson, C, Jamieson, N, Jaquet, P, Jaud-Fischer, C, Jaureguiberry, S, Jego, F, Jenum, S, Joseph, C, Joseph, M, Joshi, S, Jourdain, M, Jouvet, P, Jung, A, Juzar, D, Kafif, O, Kaguelidou, F, Kali, S, Kalomoiri, S, Kandamby, D, Kandel, C, Kanwal, D, Kataria, A, Katz, K, Kay, C, Keane, H, Keating, S, Kelly, A, Kelly, C, Kelly, N, Kelly, S, Kelly, Y, Kelsey, M, Kennon, K, Kernan, M, Kerroumi, Y, Keshav, S, Khalid, I, Khalid, O, Khalil, A, Khan, C, Khan, I, Khan, Q, Khanal, S, Khatak, A, Khawaja, A, Kho, M, Khoo, S, Khoso, N, 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M., Carroll I., Carson G., Casanova M. -L., Cascao M., Casey S., Casimiro J., Cassandra B., Castaneda S., Castanheira N., Castor-Alexandre G., Castrillon H., Castro I., Catarino A., Catherine F. -X., Cattaneo P., Cavalin R., Cavalli G. G., Cavayas A., Ceccato A., Cervantes-Gonzalez M., Chair A., Chakveatze C., Chan A., Chand M., Auger C. C., Chapplain J. -M., Chas J., Chaudry M., Iniguez J. S. C., Chen A., Chen Y. -S., Cheng M. P., Cheret A., Chiarabini T., Chica J., Chirouze C., Chiumello D., Cho S. -M., Cholley B., Chopin M. -C., Cidade J. P., Herreros J. M. C., Ciullo A., Clarke E., Clarke J., Clohisey S., Cobb P. J., Codan C., Cody C., Coelho A., Coles M., Colin G., Collins M., Colombo S. M., Combs P., Connor M., Conrad A., Contreras S., Conway E., Cooke G. S., Copland M., Cordel H., Corley A., Cornelis S., Cornet A. D., Corpuz A. 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G., Germano N., Ghosn J., Giani M., Gibson J., Gigante T., Gilg M., Gilroy E., Giordano G., Girvan M., Gissot V., Glikman D., Glybochko P., Gnall E., Goco G., Goehringer F., Goepel S., Goffard J. -C., Golob J., Gomez-Junyent J., Gominet M., Gonzalez A., Gordon P., Gorenne I., Goubert L., Goujard C., Goulenok T., Grable M., Graf J., Grandin E. W., Granier P., Grasselli G., Green C. A., Greene C., Greenhalf W., Greffe S., Grieco D. L., Griffee M., Griffiths F., Groenendijk A., Lordemann A. G., Gruner H., Gu Y., Guedj J., Guego M., Guellec D., Guerguerian A. -M., Guerreiro D., Guery R., Guillaumot A., Guilleminault L., de Castro M. G., Guimard T., Haalboom M., Haber D., Habraken H., Hachemi A., Hadri N., Haidri F., Hakak S., Hall A., Hall M., Halpin S., Hameed J., Hamer A., Hamidfar R., Hammond T., Haniffa R., Hardwick H., Harrison E. M., Harrison J., Harrison S. B. E., Hasan M. S., Hashmi J., Hayat M., Hayes A., Hays L., Heerman J., Heggelund L., Hendry R., Hennessy M., Hentzien M., Hershey A., Hesstvedt L., Hidayah A., Higgins D., Higgins E., Higgins R., Hinchion R., Hinton S., Hitoto H., Ho A., Hoctin A., Hoffmann I., Hoiting O., Holt R., Holter J. C., Horby P., Horcajada J. P., Hoshino K., Houas I., Hough C. L., Hsu J. M. -Y., Hulot J. -S., Huo S., Hurd A., Hussain I., Ijaz S., Ikram A., Illes H. -G., Imbert P., Imran M., Sikander R. I., Imtiaz A., Inacio H., Dominguez C. I., Ippolito M., Isgett S., Isidoro T., Isnard M., Ivulich D., Jaafar D., Jaafoura S., Jabot J., Jackson C., Jamieson N., Jaquet P., Jaud-Fischer C., Jaureguiberry S., Jego F., Jenum S., Garcia R. N. J., Joseph C., Joseph M., Joshi S., Jourdain M., Jouvet P., Jung A., Juzar D., Kafif O., Kaguelidou F., Kali S., Kalomoiri S., Kandamby D. H., Kandel C., Kanwal D., Kataria A., Katz K., Kay C., Keane H., Keating S., Kelly A., Kelly C., Kelly N., Kelly S., Kelly Y., Kelsey M., Kennon K., Kernan M., Kerroumi Y., Keshav S., Khalid I., Khalid O., Khalil A., Khan C., Khan I., Khan Q. A., Khanal S., Khatak A., Khawaja A., Kho M. E., Khoo S., Khoso N., Kida Y., Kiiza P., Granerud B. K., Kildal A. B., Kimmoun A., Kindgen-Milles D., Kitamura N., Klenerman P., Klont R., Bekken G. K., Knight S. R., Kobbe R., Kodippily C., Vasconcelos M. K., Koirala S., Kosgei C., Kpangon A., Krawczyk K., Kruglova O., Kumar D., Kumar M., Vijayaraghavan B. K. T., Vecham P. K., Kuriakose D., Kurtzman E., Kutsogiannis D., Kutsyna G., Kyriakoulis K., Lachatre M., Lacoste M., Laffey J. G., Lagrange M., Laine F., Lairez O., Lakhey S., Lalueza A., Lambert M., Lamontagne F., Langelot-Richard M., Langlois V., Lantang E. Y., Lanza M., Laouenan C., Laribi S., Lariviere D., Lasry S., Latif N., Launay O., Laureillard D., Lavie-Badie Y., Law A., Lawrence C., Lawrence T., Le M., Le Bihan C., Le Bris C., Le Falher G., Le Fevre L., Le Hingrat Q., Le Marechal M., Le Mestre S., Le Moal G., Le Moing V., Le Nagard H., Le Turnier P., Leal E., Santos M. L., Lee J., Lee S. H., Lee T. C., Leeming G., Lefebvre B., Lefebvre L., Lefevre B., LeGac S., Lelievre J. -D., Lellouche F., Lemaignen A., Lemee V., Lemeur A., Lemmink G., Lennon J., Leon R., Leone M., Lescure F. -X., Lesens O., Lesouhaitier M., Lester-Grant A., Levy B., Levy Y., Levy-Marchal C., Lewandowska K., L'Her E., Bassi G. L., Liaquat A., Liegeon G., Lim W. S., Lima C., Lina B., Lind A., Lingas G., Lion-Daolio S., Liu K., Livrozet M., Lizotte P., Loforte A., Lolong N., Lopes D., Loschner A. L., Loubet P., Loufti B., Louis G., Lourenco S., Lovelace-Macon L., Lowik M., Lucet J. C., Bermejo C. L., Luna C. M., Luong L., Luque N., Luton D., Lwin N., Lyons R., Maasikas O., Mabiala O., Machado M., Machado S., Macheda G., Madiha H., de la Calle G. M., Mahieu R., Mahy S., Maia A. R., Maier L. S., Maillet M., Maitre T., Malfertheiner M., Malik N., Mallon P., Maltez F., Malvy D., Manda V., Mandelbrot L., Mankikian J., Manning E., Manuel A., Sant C. M., Malaque A., Marino D., Marino F., Markowicz S., Marques A., Marquis C., Marsh B., Marsh L., Marshal M., Martelli C. T., Martin E., Martin-Blondel G., Martinot M., Martins A., Martins J., Martins N., Rego C. M., Martucci G., Martynenko O., Marwali E. M., Maslove D., Mason S., Masood S., Nor B. M., Matan M., Mathew M., Mathieu D., Mattei M., Matulevics R., Maulin L., Maxwell M., Maynar J., Mazzoni T., Mc Evoy N., Mc Sweeney L., McArthur C., McCarthy A., McCloskey C., McConnochie R., McDermott S., McDonald S. E., McElroy A., McElwee S., McEneany V., McGeer A., McKay C., McKeown J., McLean K. 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H., Reis R., Remppis J., Remy M., Ren H., Renk H., Resseguier A. -S., Revest M., Rewa O., Reyes T., Ribeiro M. I., Richardson D., Richier L., Riera J., Rios A. L., Rishu A., Rispal P., Risso K., Rizer N., Robba C., Roberto A., Roberts S., Robertson D. L., Robineau O., Roche-Campo F., Rodari P., Rodeia S., Abreu J. R., Roessler B., Roger P. -M., Rojek A., Romaru J., Roncon-Albuquerque R., Roriz M., Rosa-Calatrava M., Rose M., Rosenberger D., Rossanese A., Rossetti M., Rossignol B., Rossignol P., Rousset S., Roy C., Roze B., Rusmawatiningtyas D., Russell C. D., Ryan M., Ryckaert S., Holten A. R., Saba I., Sadaf S., Sadat M., Sahraei V., Saidani N., Saint-Gilles M., Sakiyalak P., Salahuddin N., Salazar L., Saleem J., Sales G., Sallaberry S., Gandonniere C. S., Salvator H., Sanchez O., Sanchez-Miralles A., Sancho-Shimizu V., Sandhu G., Sandhu Z., Sandrine P. -F., Sandulescu O., Santos M., Sarfo-Mensah S., Banheiro B. 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I., Udy A., Ullrich R., Uribe A., Usman A., Uyeki T. M., Vajdovics C., Val-Flores L., Valran A., Van de Velde S., van den Berge M., van der Palen J., van der Valk P., Van Der Vekens N., Van der Voort P., Van Der Werf S., van Gulik L., Van Hattem J., van Netten C., van Veen I., Vanel N., Vanoverschelde H., Varghese P., Vauchy C., Veislinger A., Vencken S., Ventura S., Verbon A., Vickers J., Vidal J. E., Vieira C., Vijayan D., Villanueva J. A., Villar J., Villeneuve P. -M., Villoldo A., Visseaux B., Visser H., Vitiello C., Vonkeman H., Vuotto F., Shukeri W. F. W. M., Wang C. -H., Webb S., Wei J., Weil K., Wesselius S., West T. E., Wham M., Whelan B., White N., Wicky P. H., Wiedemann A., Wijaya S. O., Wille K., Willems S., Williams V., Wils E. -J., Yiu N. W., Wong C., Xynogalas I., Yamazaki M., Yazdanpanah Y., Yelnik C., Yerkovich S., Yokoyama T., Yonis H., Yousif O., Yuliarto S., Zaaqoq A., Zabbe M., Zahran M., Zambon M., Zanella A., Zayyad H., Zoufaly A., and Zucman D.
- Abstract
Background: Up to 30% of hospitalised patients with COVID-19 require advanced respiratory support, including high-flow nasal cannulas (HFNC), non-invasive mechanical ventilation (NIV), or invasive mechanical ventilation (IMV). We aimed to describe the clinical characteristics, outcomes and risk factors for failing non-invasive respiratory support in patients treated with severe COVID-19 during the first two years of the pandemic in high-income countries (HICs) and low middle-income countries (LMICs). Methods: This is a multinational, multicentre, prospective cohort study embedded in the ISARIC-WHO COVID-19 Clinical Characterisation Protocol. Patients with laboratory-confirmed SARS-CoV-2 infection who required hospital admission were recruited prospectively. Patients treated with HFNC, NIV, or IMV within the first 24 h of hospital admission were included in this study. Descriptive statistics, random forest, and logistic regression analyses were used to describe clinical characteristics and compare clinical outcomes among patients treated with the different types of advanced respiratory support. Results: A total of 66,565 patients were included in this study. Overall, 82.6% of patients were treated in HIC, and 40.6% were admitted to the hospital during the first pandemic wave. During the first 24 h after hospital admission, patients in HICs were more frequently treated with HFNC (48.0%), followed by NIV (38.6%) and IMV (13.4%). In contrast, patients admitted in lower- and middle-income countries (LMICs) were less frequently treated with HFNC (16.1%) and the majority received IMV (59.1%). The failure rate of non-invasive respiratory support (i.e. HFNC or NIV) was 15.5%, of which 71.2% were from HIC and 28.8% from LMIC. The variables most strongly associated with non-invasive ventilation failure, defined as progression to IMV, were high leukocyte counts at hospital admission (OR [95%CI]; 5.86 [4.83–7.10]), treatment in an LMIC (OR [95%CI]; 2.04 [1.97–2.11]), a
- Published
- 2022
423. ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19
- Author
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A., Dahly D., Dalton H., Dalton J., Daly S., Daneman N., Daniel C., Dankwa E. A., Dantas J., de Boer M., de Loughry G., de Mendoza D., De Montmollin E., de Oliveira Franca R. F., de Pinho Oliveira A. I., De Rosa R., De Rose C., de Silva T., de Vries P., Deacon J., Dean D., Debard A., Debenedictis B., Debray M. -P., Decastro N., Dechert W., Deconninck L., Decours R., Defous E., Delacroix I., Delaveuve E., Delavigne K., Delfos N. M., Deligiannis I., Dell'amore A., Delmas C., Delobel P., Delsing C., Demonchy E., Denis E., Deplanque D., Depuydt P., Desai M., Descamps D., Desvallees M., Dewayanti S., Dhanger P., Diallo A., Diamantis S., Dias A., Diaz J. J., Diaz P., Diaz R., Didier K., Diehl J. -L., Dieperink W., Dimet J., Dinot V., Diop F., Diouf A., Dishon Y., Djossou F., Docherty A. B., Doherty H., Dondorp A. M., Dong A., Donnelly C. A., Donnelly M., Donohue C., Donohue S., Donohue Y., Doran P., Dorival C., Douangdala P., Douglas J. 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F., Ferrao J., Ferrari C., Ferraz M., Ferreira B., Ferreira I., Ferreira S., Ferrer-Roca R., Ferriere N., Ficko C., Figueiredo-Mello C., Finlayson W., Fiorda J., Flament T., Flateau C., Fletcher T., Florio L. L., Flynn B., Flynn D., Fogliazza F., Foley C., Foley J., Fomin V., Fonseca T., Fontela P., Forsyth S., Foster D., Foti G., Fourn E., Fowler R. A., Fraher M., Franch-Llasat D., Fraser C., Fraser J. F., Freire M. V., Ribeiro A. F., French C., Friedrich C., Fritz R., Fry S., Fuentes N., Fukuda M., Argin G., Gaborieau V., Gaci R., Gagliardi M., Gagnard J. -C., Gagne N., Gagneux-Brunon A., Gaiao S., Skeie L. G., Gallagher P., Curto E. G., Gamble C., Gani Y., Garan A., Garcia R., Barrio N. G., Garcia-Diaz J., Garimella N., Garofalo F., Garot D., Garrait V., Gauli B., Gault N., Gavin A., Gavrylov A., Gaymard A., Gebauer J., Geraud E., Morlaes L. G., Germano N., Ghisulal P. 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W., Hardwick H., Harrison E. M., Harrison J., Harrison S. B. E., Hartman A., Hasan M. S., Hashmi J., Hashmi M., Hayes A., Hays L., Heerman J., Heggelund L., Hendry R., Hennessy M., Henriquez-Trujillo A., Hentzien M., Hernandez-Montfort J., Herr D., Hershey A., Hesstvedt L., Hidayah A., Higgins D., Higgins E., Hinchion R., Hinton S., Hiraiwa H., Hirkani H., Hitoto H., Ho A., Ho Y. B., Hoctin A., Hoffmann I., Hoh W. H., Hoiting O., Holt R., Holter J. C., Horby P., Horcajada J. P., Hoshino K., Houas I., Hough C. L., Houltham S., Hsu J. M. -Y., Hulot J. -S., Huo S., Hussain I., Ijaz S., Illes H. -G., Imbert P., Imran M., Sikander R. I., Imtiaz A., Inacio H., Dominguez C. I., Ing Y. S., Iosifidis E., Ippolito M., Isgett S., Isidoro T., Ismail N., Isnard M., Istre M. S., Itai J., Ito A., Ivulich D., Jaafar D., Jaafoura S., Jabot J., Jackson C., Jamieson N., Jaquet P., Jassat W., Jaud-Fischer C., Jaureguiberry S., Javidfar J., Jaworsky D., Jego F., Jelani A. M., Jenum S., Jimbo-Sotomayor R., Joe O. Y., Jorge Garcia R. N., Jorgensen S. B., Joseph C., Joseph M., Joshi S., Jourdain M., Jouvet P., June J., Jung A., Jung H., Juzar D., Kafif O., Kaguelidou F., Kaisbain N., Kaleesvran T., Kali S., Kalicinska A., Kalleberg K. T., Kalomoiri S., Kamaluddin M. A. A., Kamaruddin Z. A. C., Kamarudin N., Kamineni K., Kandamby D. H., Kandel C., Kang K., Kanwal D., Kanyawati D., Karpayah P., Karsies T., Kasugai D., Kataria A., Katz K., Kaur A., Kawasaki T., Kay C., Keane H., Keating S., Kedia P., Kelly A., Kelly C., Kelly N., Kelly Y., Kelsey M., Kennedy R., Keomany S., Kernan M., Kerroumi Y., Keshav S., Kestelyn E., Khalid I., Khalid O., Khalil A., Khan C., Khan I., Khan Q. A., Khanal S., Khatak A., Khawaja A., Kherajani K., Kho M. E., Khoo D., Khoo R., Khoo S., Khoso N., Kiat K. H., Kida Y., Kihuga H., Kiiza P., Granerud B. K., Kildal A. B., Kim J. B., Kimmoun A., Kindgen-Milles D., King A., Kitamura N., Kjetland E. F. K., Klenerman P., Klont R., Bekken G. K., Knight S. R., Kobbe R., Kodippily C., Vasconcelos M. K., Koirala S., Komatsu M., Korten V., Kosgei C., Kpangon A., Krawczyk K., Krishnan S., Krishnan V., Kruglova O., Kumar D., Kumar G., Kumar M., Vecham P. K., Kuriakose D., Kurtzman E., Kusumastuti N. P., Kutsogiannis D., Kutsyna G., Kyriakoulis K., L'her E., Lachatre M., Lacoste M., Laffey J. G., Lagrange M., Laine F., Lairez O., Lakhey S., Lalueza A., Lambert M., Lamontagne F., Langelot-Richard M., Langlois V., Lantang E., Lanza M., Laouenan C., Laribi S., Lariviere D., Lasry S., Lath S., Latif N., Launay O., Laureillard D., Lavie-Badie Y., Law A., Lawrence C., Lawrence T., Le M., Le Bihan C., Le Bris C., Le Falher G., Le Fevre L., Le Hingrat Q., Le Marechal M., Le Mestre S., Le Moal G., Le Moing V., Le Nagard H., Le Turnier P., Leal E., Santos M. L., Lee B. H., Lee H. G., Lee S. H., Lee T. C., Lee Y. 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A., McNally P., McNicholas B., McPartlan E., Meaney E., Mear-Passard C., Mechlin M., Meher M., Mehkri O., Mele F., Melo L., Memon K., Mendes J., Menkiti O., Menon K., Mentre F., Mentzer A. J., Mercier E., Mercier N., Merckx A., Mergeay-Fabre M., Mergler B., Meschi T., Mesquita A., Meta R., Metwally O., Meybeck A., Meyer D., Meynert A. M., Meysonnier V., Meziane A., Mezidi M., Michelagnoli G., Michelanglei C., Michelet I., Mihelis E., Mihnovit V., Miranda-Maldonado H., Misnan N. A., Mohamed N. N. E., Mohamed T. J., Moin A., Molina D., Molinos E., Molloy B., Mone M., Monteiro A., Montes C., Montrucchio G., Moore S., Moore S. C., Cely L. M., Moro L., Tutillo D. R. M., Morton B., Motherway C., Motos A., Mouquet H., Perrot C. M., Moyet J., Mudara C., Mufti A. K., Muh N., Muhamad D., Mullaert J., Muller F., Muller K. E., Munblit D., Muneeb S., Munir N., Munshi L., Murphy A., Murphy L., Murris M., Musaab H., Mutti C., Muvindi H., Muyandy G., Myrodia D. M., Mohd-Hanafiah F. N., Nagpal D., Narasimhan M., Narayanan N., Khan R. N., Nazerali-Maitland A., Neant N., Neb H., Necsoi C., Nekliudov N. A., Nelwan E., Neto R., Neumann E., Neves B., Ng P., Ng W., Nghi A., Ngure J., Nguyen D., Choileain O. N., Leathlobhair N. N., Nichol A., Nitayavardhana P., Nonas S., Noordin N. A. M., Noret M., Norharizam N. F. I., Norman L., Notari A., Noursadeghi M., Nowicka K., Nowinski A., Nseir S., Nunez J. I., Nurnaningsih N., Nusantara D. U., Nyamankolly E., Nygaard A. B., Brien F. O., Callaghan A. O., O'callaghan A., O'donnell M., O'halloran S., O'Hearn K., O'Neil C., O'shea L., O'sullivan M., Occhipinti G., Oconnor D., Ogston T., Ogura T., Oh T. -H., Ohshimo S., Oldakowska A., Oliveira J., Oliveira L., Ong D. S. Y., Ong J. Y., Oosthuyzen W., Opavsky A., Openshaw P., Orakzai S., Orozco-Chamorro C. M., Orquera A., Ortoleva J., Osatnik J., Othman S. Z., Otiku P., Ouamara N., Ouissa R., Owyang C., Oziol E., Pagadoy M., Pages J., Palacios A., Palacios M., Palmarini M., Panarello G., Panda P. K., Paneru H., Pang L. H., Panigada M., Pansu N., Papadopoulos A., Parducci P., Paredes Ona E. F., Parke R., Parker M., Parra B., Parrini V., Pasha T., Pasquier J., Pastene B., Patauner F., Patel D., Pathmanathan M. D., Patrao L., Patricio P., Patrier J., Patrizi L., Patterson L., Pattnaik R., Paul C., Paul M., Paulos J., Paxton W. A., Payen J. -F., Peariasamy K., Jimenez M. P., Peek G. J., Peelman F., Peiffer-Smadja N., Peigne V., Pejkovska M., Pelosi P., Peltan I. D., Pereira R., Perez D., Periel L., Perpoint T., Pesenti A., Pestre V., Petrou L., Petrov-Sanchez V., Petrovic M., Pettersen F. O., Peytavin G., Pharand S., Phonemixay O., Piagnerelli M., Picard W., Picone O., de Piero M., Pierobon C., Piersma D., Pimentel C., Pinto R., Pires C., Pironneau I., Piroth L., Pisi R., Pitaloka A., Pius R., Piva S., Plantier L., Png H. 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A., Tawfik H., Tedder R. S., Tee T., Teixeira J., Tejada S., Tellier M. -C., Teoh S. K., Teotonio V., Teoule F., Terpstra P., Terrier O., Terzi N., Tessier-Grenier H., Tey A., Thabit A. A. M., Thakur A., Tham Z. D., Thangavelu S., Thibault V., Thiberville S. -D., Thill B., Thirumanickam J., Thompson S., Thomson D., Thomson E. C., Thurai S. R. T., Thuy D. B., Thwaites R. S., Ticinesi A., Tierney P., Tieroshyn V., Timashev P. S., Timsit J. -F., Vijayaraghavan B. K. T., Tissot N., Toh J. Z., Toki M., Tonby K., Tonnii S. L., Torres A., Torres M., Santos-Olmo R. M. T., Torres-Zevallos H., Towers M., Trapani T., Treoux T., Trieu H. T., Tromeur C., Trontzas I., Trouillon T., Truong J., Tual C., Tubiana S., Tuite H., Turmel J. -M., Turtle L. C. W., Tveita A., Twardowski P., Uchiyama M., Udayanga P. G. I., Udy A., Ullrich R., Uribe A., Usman A., Uyeki T. M., Vajdovics C., Val-Flores L., Valentini P., Valle A. L., Valran A., Valzano I., Van de Velde S., van den Berge M., Van der Feltz M., van der Palen J., van der Valk P., Van Der Vekens N., Van der Voort P., Van Der Werf S., van Dyk M., van Gulik L., Van Hattem J., van Netten C., Van Twillert G., van Veen I., Vanel N., Vanoverschelde H., Varghese P., Varrone M., Vasudayan S. R., Vauchy C., Veeran S., Veislinger A., Vencken S., Ventura S., Verbon A., Vickers J., Vidal J. E., Vieira C., Vijayan D., Villanueva J. A., Villar J., Villeneuve P. -M., Villoldo A., Van Vinh Chau N., Vishwanathan G., Visseaux B., Visser H., Vitiello C., Vongsouvath M., Vonkeman H., Vuotto F., Wahab N. H., Wahab S. A., Wahid N. A., Wainstein M., Wan Muhd Shukeri W. F., Wang C. -H., Webb S., Weil K., Wen T. P., Wesselius S., West T. E., Wham M., Whelan B., White N., Wicky P. H., Wiedemann A., Wijaya S. O., Wille K., Willems S., Williams V., Wils E. -J., Wong C., Wong T. F., Wong X. C., Wong Y. S., Wright N., Xian G. E., Xian L. S., Xuan K. P., Xynogalas I., Yacoub S., Mohdyakop S. R. B., Yamazaki M., Yazdanpanah Y., Hing N. L., Yelnik C., Yeoh C. H., Yerkovich S., Yiaye T., Yokoyama T., Yonis H., Yousif O., Yuliarto S., Zaaqoq A., Zabbe M., Zacharowski K., Zahid M., Zahran M., Zaidan N. Z. B., Zambon M., Zambrano M., Zanella A., Zawadka K., Zaynah N., Zoufaly A., and Zucman D.
- Abstract
The International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC) COVID-19 dataset is one of the largest international databases of prospectively collected clinical data on people hospitalized with COVID-19. This dataset was compiled during the COVID-19 pandemic by a network of hospitals that collect data using the ISARIC-World Health Organization Clinical Characterization Protocol and data tools. The database includes data from more than 705,000 patients, collected in more than 60 countries and 1,500 centres worldwide. Patient data are available from acute hospital admissions with COVID-19 and outpatient follow-ups. The data include signs and symptoms, pre-existing comorbidities, vital signs, chronic and acute treatments, complications, dates of hospitalization and discharge, mortality, viral strains, vaccination status, and other data. Here, we present the dataset characteristics, explain its architecture and how to gain access, and provide tools to facilitate its use.
- Published
- 2022
424. PFKFB3 Inhibition Impairs Erlotinib-Induced Autophagy in NSCLCs
- Author
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Nadiia Lypova, Susan M. Dougherty, Lilibeth Lanceta, Jason Chesney, and Yoannis Imbert-Fernandez
- Subjects
autophagy flux ,lung cancer ,epidermal growth factor receptor (EGFR) ,6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) ,cytoprotective autophagy ,Cytology ,QH573-671 - Abstract
Tyrosine kinase inhibitors (TKIs) targeting the kinase domain of the epidermal growth factor receptor (EGFR), such as erlotinib, have dramatically improved clinical outcomes of patients with EGFR-driven non-small cell lung carcinomas (NSCLCs). However, intrinsic or acquired resistance remains a clinical barrier to the success of FDA-approved EGFR TKIs. Multiple mechanisms of resistance have been identified, including the activation of prosurvival autophagy. We have previously shown that the expression and activity of PFKFB3—a known driver of glycolysis—is associated with resistance to erlotinib and that PFKFB3 inhibition improves the response of NSCLC cells to erlotinib. This study focuses on investigating the role of PFKFB3 in regulating erlotinib-driven autophagy to escape resistance to erlotinib. We evaluated the consequence of pharmacological inhibition of PFKFB3 on erlotinib-driven autophagy in NSCLC cells with different mutation statuses. Here, we identify PFKFB3 as a mediator of erlotinib-induced autophagy in NSCLCs. We demonstrate that PFKFB3 inhibition sensitizes NCSLCs to erlotinib via impairing autophagy flux. In summary, our studies uncovered a novel crosstalk between PFKFB3 and EGFR that regulates erlotinib-induced autophagy, thus contributing to erlotinib sensitivity in NSCLCs.
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- 2021
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425. Low-dose dual-isotope procedure planed for myocardial perfusion CZT-SPECT and assessed through a head-to-head comparison with a conventional single-isotope protocol
- Author
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Imbert, Laetitia, Roch, Véronique, Merlin, Charles, Djaballah, Wassila, Cachin, Florent, Perrin, Mathieu, Claudin, Marine, Verger, Antoine, Boutley, Henri, Karcher, Gilles, and Marie, Pierre-Yves
- Published
- 2018
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426. Downslope-shifting pockmarks: interplay between hydrocarbon leakage, sedimentations, currents and slope’s topography
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Ho, Sutieng, Imbert, Patrice, Hovland, Martin, Wetzel, Andreas, Blouet, Jean-Philippe, and Carruthers, Daniel
- Published
- 2018
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427. Evaluation of 2D and 3D interest management techniques in the distributed virtual environment DiVE
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Prendinger, Helmut, Jain, Raghvendra, Imbert, Tristian, Oliveira, João, Li, Ruijiao, and Madruga, Marconi
- Published
- 2018
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428. Anemia and bleeding in patients receiving anticoagulant therapy for venous thromboembolism: comment
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Gaboreau, Yoann, Zenatti, Nora, Vermorel, Céline, Imbert, Patrick, Bosson, Jean-Luc, and Pernod, Gilles
- Published
- 2018
- Full Text
- View/download PDF
429. Integrating photonics with silicon nanoelectronics for the next generation of systems on a chip
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Atabaki, Amir H., Moazeni, Sajjad, Pavanello, Fabio, Gevorgyan, Hayk, Notaros, Jelena, Alloatti, Luca, Wade, Mark T., Sun, Chen, Kruger, Seth A., Meng, Huaiyu, Al Qubaisi, Kenaish, Wang, Imbert, Zhang, Bohan, Khilo, Anatol, Baiocco, Christopher V., Popović, Miloš A., Stojanović, Vladimir M., and Ram, Rajeev J.
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- 2018
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- View/download PDF
430. TNFα blockade overcomes resistance to anti-PD-1 in experimental melanoma
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Florie Bertrand, Anne Montfort, Elie Marcheteau, Caroline Imbert, Julia Gilhodes, Thomas Filleron, Philippe Rochaix, Nathalie Andrieu-Abadie, Thierry Levade, Nicolas Meyer, Céline Colacios, and Bruno Ségui
- Subjects
Science - Abstract
Most melanoma patients do not respond to anti-PD1 therapy. Here, the authors show that TNFα blockade synergizes with anti-PD-1 by preventing anti-PD-1-induced CD8+ T cell death and TIM-3 expression on such cells.
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- 2017
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431. 'Il tremolar della marina' ou la contribution de Dante à une poétique moderne de la Méditerranée
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Christophe Imbert
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Maurras (Charles) ,tremolar ,tremblement ,lumière ,notation coloriste ,Romania ,English language ,PE1-3729 - Abstract
Oscar Wilde in The Decay of Lying assumes that "at present, people see fogs, not because they are fogs, but because poets and painters have taught them the mysterious loveliness of such effects." We would like to demonstrate that the quivering of the sea with the light of dawn, expressed by so many authors in the 19th and 20th centuries, was made visible only through the ancient and magnificent veil of Dante’s words. Such is the case, probably, for Lamartine, and surely for Carlyle, Ruskin, or Augustus Hare, author of so many traveller’s guides. The memory of this verse by Dante is still present and active in a poem by D’Annunzio when suddenly the shepherds coming from the hinterland perceive the sea and in Moreas’ poetry and Maurras’ thought at the time when they were founding the Ecole Romane. This quivering stretch of sea is ultimately a real part of Ezra Pound’s mosaic in his Cantos (Canto XCII), far beyond any picturesque touch. Quite obviously, Dante’s skill is deeply responsible for the making of a modern poetics of the Mediterranean.
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- 2017
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432. Síndrome de Stevens-Johnson. Presentación de un caso con reacción medicamentosa severa
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Leyanis Martínez Pérez, Leonides Wilson Chibás, Yoneidis Imbert Fuentes, and Sara Jane Simons Preval
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síndrome Stevens-Johnson ,tratamiento ,reacción medicamentosa ,Medicine - Abstract
El síndrome de Stevens-Johnson es una enfermedad ampollosa severa, que puede ocasionar la muerte si no es tratado oportunamente. Se presentó el caso de un paciente masculino, de 3 años de edad, atendido con múltiples lesiones en piel y mucosas, y toma del estado general hasta la gravedad. Se realizó diagnóstico y tratamiento multidisciplinario con evolución satisfactoria al egreso.
- Published
- 2017
433. Simulations, explication, compréhension : essai d’analyse critique
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Cyrille Imbert
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Philosophy (General) ,B1-5802 - Abstract
In this paper I investigate the potential explanatory value of computer simulations, which are often said to be suitable tools for the prediction, emulation or imitation of phenomena, but not for their explanation. Similarly, they are described as providing brute force (number-crunching) methods that are helpful to investigate the behaviour of physical systems but less so when it comes to understanding them. Be this as it may, wrongly or not simulations seem to be raising specific problems concerning their potential explanatory value. I try to systematically analyze these problems and for this purpose use existing theories of explanations as analytical guidelines. I first investigate how simulations fare concerning truth (section 2) and proceed by analyzing whether they satisfy the deductivity and nomicity requirements, which play a central role in Hempel’s model of explanation (section 3). I also study whether simulations are appropriate vehicles for relevant causal information which a good explanation is expected to provide (section 4). I then analyze how much the informational repleteness and the inferential or computational stodginess of computer simulations are problems for the development of explanatory knowledge and our understanding of phenomena (section 5). I finally analyze how much computer simulations can have a unificatory role as good explanations arguably do (section 6). Overall, I try to analyze why computer simulations still raise specific problems concerning explanations while seemingly being able to meet the criteria that explanations should fulfil. I suggest that some of these reasons are to be found in the epistemology of explanatory activity, in methodological expectations towards good explanations and in the specific uses that are made of computer simulations to investigate complex systems—in addition to the fact that computer simulations are not human-sized activities and that, as such, they may fail to provide first person understanding of phenomena.
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- 2017
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434. Hölder gradient estimates for a class of singular or degenerate parabolic equations
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Imbert Cyril, Jin Tianling, and Silvestre Luis
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regularity ,degenerate parabolic equations ,singular parabolic equations ,35b65 ,35k92 ,35k65 ,35k67 ,Analysis ,QA299.6-433 - Abstract
We prove interior Hölder estimates for the spatial gradients of the viscosity solutions to the singular or degenerate parabolic equation
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- 2017
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435. Mediciones de índice Mayoral y diámetro transversal de maxilares, comparación en estudiantes de Secundaria Básica
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Roselis Delgado Velázquez, Yoneidis Imbert Fuentes, Eloísa Beatriz Legrá Silot, María Elvira Calavia Infante, and Mary Nelys Zamora Rodríguez
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análisis transversal ,mediciones de Mayoral ,micrognatismo transversal ,diámetro transversal ,Medicine - Abstract
Se realizó un estudio descriptivo de tipo transversal en el período noviembre 2013 mayo 2016, para comparar las mediciones de Mayoral con el diámetro transversal de los maxilares en los estudiantes de 12-14 años de la ESBU "Pedro Pablo Pérez" Guantánamo. El universo estuvo conformado por 60 estudiantes de 12 a 14 años de la entidad educativa. Las variables estudiadas fueron edad, sexo, medidas transversales de los maxilares, medidas transversales de Mayoral y su significación diagnóstica. Se efectuaron mediciones de las distancias transversales entre los primeros y segundos premolares y primeros molares superiores permanentes y se compararon los parámetros obtenidos con las referencias establecidas por mayoral. La investigación reveló mayor cantidad de pacientes femeninos que masculinos, donde se encontraron variaciones entre sexos en los análisis dentales, predominando con mayores diámetros el sexo masculino. Se evidenció una diferencia estadísticamente significativa entre las medidas transversales de la población estudiada y las medidas establecidas por mayoral.
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- 2017
436. Evaluación de competencia profesional de enfermería en cuidados intensivos adultos en aspiración endotraqueal
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Reudis Durán Rodríguez, Irayma Cazull Imbert, Aniuska Pérez Reinosa, and Andrés Correa Pita
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competencia ,competencia profesional ,enfermería ,cuidados intensivos ,adulto ,Medicine - Abstract
Se realizó una investigación prospectiva y longitudinal en la Unidad de Cuidados Intensivos de Adultos del Hospital General Docente "Octavio de la Concepción y de la Pedraja" de Baracoa, con el objetivo de evaluar la competencia del profesional de enfermería en relación con técnica de aspiración endotraqueal, durante enero 2015- agosto 2016. El estudio se realizó con el total de enfermeras y enfermeros que laboran en la UTIAs, 37. Se realizó un examen teórico y práctico de evaluación de competencia a los profesionales de enfermería de UTIAs y la técnica de aspiración endotraqueal. El mayor por ciento entre Licenciados en Enfermería y verticalizados presentaron una evaluación de mal, las sepsis aumentaron a partir del cuarto día de ingreso de los pacientes. Mostrando un grado marcado de incompetencia en la realización de este proceder invasivo que a su vez influye en la seguridad del paciente.
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- 2017
437. Diagnosis of sudden death at the «Hospital Dr. Agostinho Neto» in Guantánamo, Cuba
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Irayma Cazull Imbert, Raúl Hernández Heredia, and Abel Creagh Cazull
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Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Introduction: The diagnosis of sudden death represents a challenge for health systems worldwide. Objective: To assess trends in the diagnosis of sudden death. Method: Cross-sectional, retrospective and correlational study in 58 cases diagnosed with sudden death who were performed an autopsy at the «Hospital Agostinho Neto» of Guantánamo, Cuba, in 2015. Results: Deceased patients with the above mentioned diagnosis predominated, males (56.9%) at the out-of-hospital setting (55.2%) and due to non-ischemic causes (58.6%). In 51.6%, the diagnosis was not issued as stated in the international nomenclature. The 90% of the sudden cardiac ischemic deaths was produced by acute myocardial infarction and in 88.2% of the non-ischemic cases, global cardiomegaly was observed with hypertrophy or dilatation, or both, of the cardiac cavities. A correlation between the corrected and direct causes of death was found, as well as between the intermediate and basic ones. Conclusions: The out-of-hospital sudden death prevailed. There was no demonstrated the correlation between the place of death, the age groups and sex with the basic and direct causes of death, but there was an actual relationship between the direct cause of original death and the corrected one, denoting that the sudden death diagnosis was not stated as in the international nomenclature.
- Published
- 2017
438. EEG-Based Cognitive Control Behaviour Assessment: an Ecological study with Professional Air Traffic Controllers
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Gianluca Borghini, Pietro Aricò, Gianluca Di Flumeri, Giulia Cartocci, Alfredo Colosimo, Stefano Bonelli, Alessia Golfetti, Jean Paul Imbert, Géraud Granger, Railane Benhacene, Simone Pozzi, and Fabio Babiloni
- Subjects
Medicine ,Science - Abstract
Abstract Several models defining different types of cognitive human behaviour are available. For this work, we have selected the Skill, Rule and Knowledge (SRK) model proposed by Rasmussen in 1983. This model is currently broadly used in safety critical domains, such as the aviation. Nowadays, there are no tools able to assess at which level of cognitive control the operator is dealing with the considered task, that is if he/she is performing the task as an automated routine (skill level), as procedures-based activity (rule level), or as a problem-solving process (knowledge level). Several studies tried to model the SRK behaviours from a Human Factor perspective. Despite such studies, there are no evidences in which such behaviours have been evaluated from a neurophysiological point of view, for example, by considering brain activity variations across the different SRK levels. Therefore, the proposed study aimed to investigate the use of neurophysiological signals to assess the cognitive control behaviours accordingly to the SRK taxonomy. The results of the study, performed on 37 professional Air Traffic Controllers, demonstrated that specific brain features could characterize and discriminate the different SRK levels, therefore enabling an objective assessment of the degree of cognitive control behaviours in realistic settings.
- Published
- 2017
- Full Text
- View/download PDF
439. Food waste valorization options: opportunities from the bioeconomy
- Author
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Imbert Enrica
- Subjects
food waste ,food waste valorization practices ,secondary biomass ,bioeconomy ,Agriculture ,Agriculture (General) ,S1-972 - Abstract
The world is confronted with the depletion of natural resources due to their unsustainable use, increased global competiveness, increasing population and other environmental and economic challenges. Under the European 2020 growth strategy launched in 2010, Europe has set itself the goal of shifting from linear to circular models of production and consumption. In this context, food waste management poses a great challenge. This study focusses on the possible destinations for food waste, specifically, on the most sustainable practices that turn waste into valuable resources. Particular attention is devoted to the potential offered by fast-growing sectors such as the bioeconomy, which is contributing to increased energy and materials production with reduced environmental impact, at the same time creating new job opportunities. In this paper we will argue that an holistic approach considering the issue of food wastage as part of a broader emerging bio-economy and circular-economic model, might provide win-win solutions able to minimize wastage, promote income growth and job creation, and prompt sustainable local development. However, in order to enable an effective transition to a circular bioeconomy able to minimize the impact of food wastage, the economic, social, and environmental sustainability of this new model must be properly evaluated through appropriate tools, e.g. through an overall Life Cycle Sustainability Assessment (LCSA).
- Published
- 2017
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440. Utilización de prácticas agrícolas como estrategia efectiva para mitigar la degradación de los suelos e incrementar la captura de carbono
- Author
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Albaro Blanco Imbert, Illovis Fernández Betancourt, Teudys Limeres Jiménez, Marianela Cintra Arencibia, José Fuentes Quintana, Roberto Sanchez Rojas, Antonio Barzaga Lobaina, and Abel Castillo Duran
- Subjects
degradación ,preservación ,reserva de carbono ,erosiojn ,barreras vivas ,Agriculture (General) ,S1-972 - Abstract
Se presentan los resultados de la utilización de prácticas para prevenir o mitigar la degradación de los suelos e incrementar la captura de carbono. El estudio se desarrolló en la finca “Los Bárzaga”, en la provincia Guantánamo, donde el mal drenaje, la baja fertilidad y erosión del suelo, afectan el 90% del área, ocasionando una mayor manifestación de los procesos de degradación y disminución de los resultados productivos. Se establecieron medidas de conservación y mejoramiento de suelos atendiendo a los factores limitantes identificados y se evaluaron índices físicos y químicos además de monitorear la reserva de carbono. Las prácticas aplicadas (barreras vivas, barreras muertas, corrección de cárcavas y tranques) permitieron disminuir la pérdida de suelos en 62 t. ha-1, ocasionando cambios positivos en los índices físicos densidad aparente, velocidad de infiltración y compactación, así como en el contenido de nutrientes. Igualmente se incrementó la reserva de carbono en el suelo 20.67%.
- Published
- 2017
441. Agricultural Practices to Mitigate Soil Degradation and Increase Carbon Capture
- Author
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Albaro Blanco Imbert, Illovis Fernández Betancourt, Teudys Limeres Jiménez, Marianela Cintra Arencibia, José Fuentes Quintana, Roberto Sanchez Rojas, Antonio Barzaga Lobaina, and Abel Castillo Duran
- Subjects
degradation ,preservation ,carbon reserves ,erosion ,live barriers ,Agriculture (General) ,S1-972 - Abstract
The implementation of new practices and their results to prevent or mitigate soil degradation and increase carbon capture were presented in this paper. The study was made on "Los Barzaga" farm, in the province of Guantanamo, where poor drainage conditions, low soil fertility and erosion affect 90% of the area, causing greater degradation and reduction of production. Several soil preservation and improvement procedures were established, considering the limiting factors identified. The physical and chemical indexes were evaluated, and the carbon reserves were monitored. The practices implemented (live and dead barriers, rill and reservoir correction), contributed to a 62 t. ha-1 reduction of soil loss, with positive changes in apparent density, infiltration and compacting velocity, and nutrient contents. Additionally, soil carbon increased to 20.67%.
- Published
- 2017
442. Actions to Restore Degraded Soil in the Southern Coastline of Guantanamo
- Author
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Illovis Fernández Betanc, Albaro Blanco Imbert, Teudys Limeres Jiménez, Marianela Cintra Arencibia, José Ramón Fuentes Quintana, Roberto Sanchez Rojas, Abel Castillo, and Antonio Pineda Labañino
- Subjects
Guaiacum officinalis ,erosion ,restoration ,preservation ,reforestation ,Agriculture (General) ,S1-972 - Abstract
In the southern coastline of the province of Guantanamo, Cuba, there are communities that have lost several hectares of soil and biodiversity due to land mismanagement. "Los Cerezos" community is located in the municipality of Imias, as part of the “Eliomar Noa” UBPC (Basic Unit for Cooperated Production), which uses 99.2% of their areas for livestock raising. The land is on hills covered with xerophytic bushes; signs of degradation are clearly observed. Restoration is one alternative to revert this situation. It constitutes an effective preservation technique implemented by man to achieve optimum recovery of degraded ecosystems close to their original states. The aim of this paper is to evaluate the results achieved after recovery of local soils, using restoration techniques. Research was done in a fragmented forest, on typical red-brown fersiallitic soil, where the limiting factors were determined (rills, slopes, effective depth, organic matter content, rocks, and erosion), as well as other negative factors that may have an effect on vegetation growth. Common Ligum-vitae (Guaiacum officinalis L.) was used for reforestation due to its adaptability to the ecosystem. The restoration works helped create the conditions for progressive recovery of the areas and mitigate soil degradation, with a decrease in losses of 1 036 t. ha-1 every year, thanks to barrier accumulation.
- Published
- 2017
443. Osteosarcoma without prior retinoblastoma related to RB1 low‐penetrance germline pathogenic variants: A novel type of RB1‐related hereditary predisposition syndrome?
- Author
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Marion Imbert‐Bouteille, Marion Gauthier‐Villars, Dominique Leroux, Isabelle Meunier, Isabelle Aerts, Livia Lumbroso‐Le Rouic, Sophie Lejeune, Capucine Delnatte, Caroline Abadie, Pascal Pujol, Claude Houdayer, and Carole Corsini
- Subjects
cancer screening ,low penetrance ,Osteosarcoma ,RB1 ,Sarcoma ,whole‐body MRI ,Genetics ,QH426-470 - Abstract
Abstract Background Retinoblastoma (Rb) is a rare intraocular malignant tumor in children with high overall survival. Predisposition to Rb is linked to RB1 germline mutations with high penetrance, but rare RB1 low‐penetrance variants are also known. Rb survivors are at risk of second primary malignancies (SPMs), mostly osteosarcoma and soft‐tissue sarcoma. Nevertheless, the risk of primary osteosarcoma developing without prior Rb has not been reported in RB1 germline mutation carriers. Methods We report a patient in whom osteosarcoma developed at age 17 as a first primary malignancy within a family context of sarcoma. Results Unexpectedly, genetic testing identified a low‐penetrance germline mutation in RB1 [NM_000321.2: c.45_76dup; p.(Pro26Leufs*50)]. In eight additional similar cases from published and unpublished reports of families, first primary osteosarcomas and sarcomas mostly developed in RB1 low‐penetrance mutation carriers without prior Rb. Conclusion We propose that first primary sarcoma and osteosarcoma could be a novel clinical presentation of a RB1‐related hereditary predisposition syndrome linked to RB1 low‐penetrance germline mutations. In these families, careful screening of primary non‐Rb cancer and SPMs is required by maintaining enhanced clinical vigilance. Implementing lifelong periodic whole‐body MRI screening might be a complementary strategy for unaffected carrier relatives in these families.
- Published
- 2019
- Full Text
- View/download PDF
444. How Neurophysiological Measures Can be Used to Enhance the Evaluation of Remote Tower Solutions
- Author
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Pietro Aricò, Maxime Reynal, Gianluca Di Flumeri, Gianluca Borghini, Nicolina Sciaraffa, Jean-Paul Imbert, Christophe Hurter, Michela Terenzi, Ana Ferreira, Simone Pozzi, Viviana Betti, Matteo Marucci, Alexandru C. Telea, and Fabio Babiloni
- Subjects
EEG ,ECG ,GSR ,eye blink ,mental workload ,remote tower air traffic management ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
New solutions in operational environments are often, among objective measurements, evaluated by using subjective assessment and judgment from experts. Anyhow, it has been demonstrated that subjective measures suffer from poor resolution due to a high intra and inter-operator variability. Also, performance measures, if available, could provide just partial information, since an operator could achieve the same performance but experiencing a different workload. In this study, we aimed to demonstrate: (i) the higher resolution of neurophysiological measures in comparison to subjective ones; and (ii) how the simultaneous employment of neurophysiological measures and behavioral ones could allow a holistic assessment of operational tools. In this regard, we tested the effectiveness of an electroencephalography (EEG)-based neurophysiological index (WEEG index) in comparing two different solutions (i.e., Normal and Augmented) in terms of experienced workload. In this regard, 16 professional air traffic controllers (ATCOs) have been asked to perform two operational scenarios. Galvanic Skin Response (GSR) has also been recorded to evaluate the level of arousal (i.e., operator involvement) during the two scenarios execution. NASA-TLX questionnaire has been used to evaluate the perceived workload, and an expert was asked to assess performance achieved by the ATCOs. Finally, reaction times on specific operational events relevant for the assessment of the two solutions, have also been collected. Results highlighted that the Augmented solution induced a local increase in subjects performance (Reaction times). At the same time, this solution induced an increase in the workload experienced by the participants (WEEG). Anyhow, this increase is still acceptable, since it did not negatively impact the performance and has to be intended only as a consequence of the higher engagement of the ATCOs. This behavioral effect is totally in line with physiological results obtained in terms of arousal (GSR), that increased during the scenario with augmentation. Subjective measures (NASA-TLX) did not highlight any significant variation in perceived workload. These results suggest that neurophysiological measure provide additional information than behavioral and subjective ones, even at a level of few seconds, and its employment during the pre-operational activities (e.g., design process) could allow a more holistic and accurate evaluation of new solutions.
- Published
- 2019
- Full Text
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445. Static Metabolic Bubbles as Precursors of Vascular Gas Emboli During Divers’ Decompression: A Hypothesis Explaining Bubbling Variability
- Author
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Jean-Pierre Imbert, Salih Murat Egi, Peter Germonpré, and Costantino Balestra
- Subjects
diving ,decompression sickness ,desaturation ,oxygen window ,pre-conditioning ,Physiology ,QP1-981 - Abstract
IntroductionThe risk for decompression sickness (DCS) after hyperbaric exposures (such as SCUBA diving) has been linked to the presence and quantity of vascular gas emboli (VGE) after surfacing from the dive. These VGE can be semi-quantified by ultrasound Doppler and quantified via precordial echocardiography. However, for an identical dive, VGE monitoring of divers shows variations related to individual susceptibility, and, for a same diver, dive-to-dive variations which may be influenced by pre-dive pre-conditioning. These variations are not explained by currently used algorithms. In this paper, we present a new hypothesis: individual metabolic processes, through the oxygen window (OW) or Inherent Unsaturation of tissues, modulate the presence and volume of static metabolic bubbles (SMB) that in turn act as precursors of circulating VGE after a dive.MethodsWe derive a coherent system of assumptions to describe static gas bubbles, located on the vessel endothelium at hydrophobic sites, that would be activated during decompression and become the source of VGE. We first refer to the OW and show that it creates a local tissue unsaturation that can generate and stabilize static gas phases in the diver at the surface. We then use Non-extensive thermodynamics to derive an equilibrium equation that avoids any geometrical description. The final equation links the SMB volume directly to the metabolism.Results and DiscussionOur model introduces a stable population of small gas pockets of an intermediate size between the nanobubbles nucleating on the active sites and the VGE detected in the venous blood. The resulting equation, when checked against our own previously published data and the relevant scientific literature, supports both individual variation and the induced differences observed in pre-conditioning experiments. It also explains the variability in VGE counts based on age, fitness, type and frequency of physical activities. Finally, it fits into the general scheme of the arterial bubble assumption for the description of the DCS risk.ConclusionMetabolism characterization of the pre-dive SMB population opens new possibilities for decompression algorithms by considering the diver’s individual susceptibility and recent history (life style, exercise) to predict the level of VGE during and after decompression.
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- 2019
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446. 2HybridTools, a handy software to facilitate clone identification and mutation mapping from yeast two-hybrid screening
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Pierre Cauchy, Brigitte Kahn-Perlès, Pierre Ferrier, Jean Imbert, and Patrick Lécine
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Two-hybrid ,Reverse two-hybrid ,Analysis ,Software ,Identification ,Mutation ,Medicine ,Biology (General) ,QH301-705.5 - Abstract
Yeast Two-Hybrid (Y2H) and reverse Two-Hybrid (RY2H) are powerful protein–protein interaction screening methods that rely on the interaction of bait and prey proteins fused to DNA binding (DB) and activation domains (AD), respectively. Y2H allows identification of protein interaction partners using screening libraries, while RY2H is used to determine residues critical to a given protein–protein interaction by exploiting site-directed mutagenesis. Currently, both these techniques still rely on sequencing of positive clones using conventional Sanger sequencing. For Y2H, a screen can yield several positives; the identification of such clones is further complicated by the fact that sequencing products usually contain vector sequence. For RY2H, obtaining a complete sequence is required to identify the full range of residues involved in protein–protein interactions. However, with Sanger sequencing limited to 500–800 nucleotides, sequencing is usually carried from both ends for clones greater than this length. Analysis of such RY2H data thus requires assembly of sequencing products combined with trimming of vector sequences and of low-quality bases at the beginning and ends of sequencing products. Further, RY2H analysis requires collation of mutations that abrogate a DB/AD interaction. Here, we present 2HybridTools, a Java program with a user-friendly interface that allows addressing all these issues inherent to both Y2H and RY2H. Specifically, for Y2H, 2HybridTools enables automated identification of positive clones, while for RY2H, 2HybridTools provides detailed mutation reports as a basis for further investigation of given protein–protein interactions.
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- 2019
- Full Text
- View/download PDF
447. Commercial Divers’ Subjective Evaluation of Saturation
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Jean Pierre Imbert, Costantino Balestra, Fatima Zohra Kiboub, Øyvind Loennechen, and Ingrid Eftedal
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saturation diving ,diving fatigue ,headache ,hemoglobin ,long term health effects ,relative hypoxia ,Psychology ,BF1-990 - Abstract
Commercial saturation diving involves divers living and working in an enclosed atmosphere with elevated partial pressure of oxygen (ppO2) for weeks. The divers must acclimatize to these conditions during compression, and for up to 28 days until decompression is completed. During decompression, the ppO2 and ambient pressure are gradually decreased; then the divers must acclimatize again to breathing normal air in atmospheric pressure when they arrive at surface. We investigated 51 saturation divers’ subjective evaluation of the saturation and post-decompression phase via questionnaires and individual interviews. The questions were about decompression headaches and fatigue; and time before recovering to a pre-saturation state. Twenty-two (44%) of the divers who responded declared having headaches; near surface (44%) or after surfacing (56%). 71% reported post-saturation fatigue after their last saturation, 82% of them described it as typical and systematic after each saturation. Recovery was reported to normally take from 1 to 10 days. The fatigue and headaches observed are compatible with divers’ acclimatization to the changes in ppO2 levels during saturation and decompression. They appear to be reversible post- decompression.
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- 2019
- Full Text
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448. Clinical Origin and Species Distribution of Fusarium spp. Isolates Identified by Molecular Sequencing and Mass Spectrometry: A European Multicenter Hospital Prospective Study
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Anne-Cécile Normand, Sébastien Imbert, Sophie Brun, Abdullah M. S. Al-Hatmi, Erja Chryssanthou, Sophie Cassaing, Christine Schuttler, Lilia Hasseine, Caroline Mahinc, Damien Costa, Christine Bonnal, Stéphane Ranque, Marc Sautour, Elisa Rubio, Laurence Delhaes, Arnaud Riat, Boualem Sendid, Lise Kristensen, Marcel Brandenberger, Juliette Guitard, Ann Packeu, Renaud Piarroux, and Arnaud Fekkar
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fusariosis ,mALDI ToF mass spectrometry ,DNA sequencing ,elongation factor ,Fusarium species complex ,Biology (General) ,QH301-705.5 - Abstract
Fusarium spp. are widespread environmental fungi as well as pathogens that can affect plants, animals and humans. Yet the epidemiology of human fusariosis is still cloudy due to the rapidly evolving taxonomy. The Mass Spectrometry Identification database (MSI) has been developed since 2017 in order to allow a fast, accurate and free-access identification of fungi by matrix-assisted laser desorption ionization—time of flight (MALDI-TOF) mass spectrometry. Taking advantage of the MSI database user network, we aim to study the species distribution of Fusarium spp. isolates in an international multicenter prospective study. This study also allowed the assessment of the abilities of miscellaneous techniques to identify Fusarium isolates at the species level. The identification was performed by PCR-sequencing and phylogenic-tree approach. Both methods are used as gold standard for the evaluation of mass spectrometry. Identification at the species complex was satisfactory for all the tested methods. However, identification at the species level was more challenging and only 32% of the isolates were correctly identified with the National Center for Biotechnology Information (NCBI) DNA database, 20% with the Bruker MS database and 43% with the two MSI databases. Improvement of the mass spectrometry database is still needed to enable precise identification at the species level of any Fusarium isolates encountered either in human pathology or in the environment.
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- 2021
- Full Text
- View/download PDF
449. Quels vaccins peut-on faire en même temps ?
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Janssen, C., Imbert, P., and Goujon, C.
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- 2020
- Full Text
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450. Paludisme
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Minodier, P., primary and Imbert, P., additional
- Published
- 2018
- Full Text
- View/download PDF
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