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408. ITER neutral beam system

Author

Mondino, P.L, primary, Bayetti, P, additional, Pietro, E. Di, additional, Hemsworth, R.S, additional, Iida, H, additional, Inoue, T, additional, Ioki, K, additional, Johnson, G, additional, Krylov, A.I, additional, Kulygin, V.M, additional, Massmann, P, additional, Miyamoto, K, additional, Okumura, Y, additional, Panasenkov, A.A, additional, Santoro, R.T, additional, Sironi, M, additional, Utin, Y, additional, Watanabe, K, additional, and Yamada, M, additional

Published
2000
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411. Prognostic significance of the cell cycle inhibitor p27Kip1 in acute myeloid leukemia

Author

Yokozawa, T, primary, Towatari, M, additional, Iida, H, additional, Takeya, K, additional, Tanimoto, M, additional, Kiyoi, H, additional, Motoji, T, additional, Asou, N, additional, Saito, K, additional, Takeuchi, M, additional, Kobayashi, Y, additional, Miyawaki, S, additional, Kodera, Y, additional, Ohno, R, additional, Saito, H, additional, and Naoe, T, additional

Published
2000
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414. FED-A, an advanced performance FED based on low safety factor and current drive

Author

Peng, Yueng Kay Martin, primary, Rutherford, P. H., additional, Hogan, J.T., additional, Attenberger, S. E., additional, Holmes, J.A., additional, Borowski, S. K., additional, Brown, T. G., additional, Carreras, B. A., additional, Ehst, D. A., additional, Haines, J.R., additional, Hively, L. M., additional, Houlberg, Wayne A, additional, Iida, H., additional, Lee, V. D., additional, Lynch, S.J., additional, Reid, R. L., additional, Rothe, K. E., additional, Strickler, Dennis J, additional, and Stewart, L. D., additional

Published
1983
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415. Muscle size and arterial stiffness after blood flow-restricted low-intensity resistance training in older adults.

Author

Yasuda, T., Fukumura, K., Fukuda, T., Uchida, Y., Iida, H., Meguro, M., Sato, Y., Yamasoba, T., and Nakajima, T.

Subjects
MUSCULAR atrophy, ANALYSIS of variance, BLOOD flow measurement, EXERCISE, HEMODYNAMICS, LEG, MAGNETIC resonance imaging, MUSCLE strength, RESEARCH funding, STATISTICS, DATA analysis, REPEATED measures design, DATA analysis software, DESCRIPTIVE statistics, OLD age, PREVENTION
Abstract

Previous studies have shown that blood flow-restricted low-intensity resistance training (BFR-RT) causes muscle hypertrophy while maintaining arterial function in young adults. We examined the effects of BFR-RT on muscle size and arterial stiffness in older adults. Healthy subjects (ages 61–84 years) were divided into BFR-RT (n = 9) or non-training control (CON; n = 10) groups. The BFR-RT group performed 20% and 30%, respectively, of one repetition maximal (1-RM) knee extension and leg press exercises, 2 days/wk for 12 weeks. The BFR-RT group wore elastic cuffs (120–270 mmHg) on both legs during training. Magnetic resonance imaging-measured muscle cross-sectional area (CSA), 1-RM strength, chair stand (CS) test, and cardio-ankle vascular index testing (CAVI), an index of arterial stiffness, were measured before and 3–5 days after the final training session. Muscle CSA of the quadriceps (8.0%), adductors (6.5%), and gluteus maximus (4.4%), leg extension and leg press 1-RM strength (26.1% and 33.4%), and CS performance (18.3%) improved (P < 0.05) in the BFR-RT group, but not in the CON group. In CAVI testing, there were no changes in both two groups. In conclusion, BFR-RT improves muscle CSA as well as maximal muscle strength, but does not negatively affect arterial stiffness or humeral coagulation factors in older adults. [ABSTRACT FROM AUTHOR]

Published
2014
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416. Effects of low-intensity, elastic band resistance exercise combined with blood flow restriction on muscle activation.

Author

Yasuda, T., Fukumura, K., Fukuda, T., Iida, H., Imuta, H., Sato, Y., Yamasoba, T., and Nakajima, T.

Subjects
MUSCLE strength, EXERCISE equipment, ANALYSIS of variance, BLOOD circulation, BLOOD pressure, STATISTICAL correlation, ELECTROMYOGRAPHY, EXERCISE, RANGE of motion of joints, LACTATES, LONGITUDINAL method, PROBABILITY theory, RESEARCH funding, STATISTICS, DATA analysis, REPEATED measures design, EXERCISE intensity, DATA analysis software, DESCRIPTIVE statistics, RESISTANCE training
Abstract

We examined the effects of blood flow-restricted, low-intensity resistance exercise (termed kaatsu) using an elastic band for resistance on muscle activation. Nine men performed triceps extension and biceps flexion exercises (four sets respectively) using an elastic band for resistance with blood flow restriction ( BFR) or CON (unrestricted blood flow). During a BFR session, subjects wore pressure cuffs inflated to 170-260 mmHg on the proximal region of both arms. Surface electromyography ( EMG) was recorded from the triceps brachii and biceps brachii muscles, and mean integrated EMG (iEMG) was analyzed. Blood lactate concentration was obtained before ( Pre) and immediately after two exercises ( Post). During triceps extension and biceps flexion exercises, muscle activation increased progressively ( P < 0.05) under BFR (46% and 69%, respectively) but not under CON (12% and 23%, respectively). Blood lactate concentration at Post was higher ( P < 0.05) under BFR than under CON (3.6 and 2.1 mmol/L, respectively). Blood lactate concentration at Post was significantly correlated with increased iEMG in both triceps extension ( r = 0.65, P < 0.01) and biceps flexion exercises ( r = 0.52, P < 0.05). We conclude that kaatsu training using elastic bands for resistance enhances muscle activation and may be an effective method to promote muscle hypertrophy in older adults or patients with a low level of activity. [ABSTRACT FROM AUTHOR]

Published
2014
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417. New candidates for mechano-sensitive channels potentially involved in gravity sensing in Arabidopsis thaliana.

Author

Iida, H., Furuichi, T., Nakano, M., Toyota, M., Sokabe, M., Tatsumi, H., and Legué, V.

Subjects
*ARABIDOPSIS thaliana, *BIOPHYSICS, *TURGOR, *EFFECT of stress on plants, *PLANT membranes, *PLANT cells & tissues, *PLASTIDS, *PLANT genomes
Abstract

The mechano-sensitive channels of plants may sense increases in tension induced by mechanical stimuli, such as touch, wind and turgor pressure, and a gravitational stimulus. Recent studies have identified plant homologues of the bacterial mechano-sensitive channel MscS, which is gated by membrane tension and reduces intracellular osmolality by releasing small osmolytes from bacterial cells. However, the physiological roles of these homologues have not yet been clearly elucidated, and only two of them have been shown to be involved in the protection of osmotically stressed plastids in Arabidopsis thaliana. We identified another group of candidates for mechano-sensitive channels in Arabidopsis, named MCA1 and MCA2, whose homologues are exclusively found in plant genomes. MCA1 and MCA2 are composed of 421 and 416 amino acid residues, respectively, share 73% homology in their amino acid sequences, and are not homologous to any known ion channels or transporters. Our structural study revealed that the N-terminal region (one to 173 amino acids) of both proteins was necessary and sufficient for Ca2+ influx activity. Interestingly, this region had one putative transmembrane segment containing an Asp residue whose substitution mutation abolished this activity. Our physiological study suggested that MCA1 expressed at the root tip was required for sensing the hardness of the agar medium or soil. In addition, MCA1 and MCA2 were shown to be responsible for hypo-osmotic shock-induced increases in [Ca2+]cyt. Thus, both proteins appear to be involved in the process of sensing mechanical stresses. We discussed the possible role of both proteins in sensing mechanical and gravitational stimuli. [ABSTRACT FROM AUTHOR]

Published
2014
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418. Mechanosensitive channels are activated by stress in the actin stress fibres, and could be involved in gravity sensing in plants.

Author

Tatsumi, H., Furuichi, T., Nakano, M., Toyota, M., Hayakawa, K., Sokabe, M., Iida, H., and Palme, K.

Subjects
EFFECT of stress on plants, ACTIN, PLANT fibers, BIOPHYSICS, CYTOSKELETON, PHYTOTHERAPY, CALCIUM channels
Abstract

Mechanosensitive ( MS) channels are expressed in a variety of cells. The molecular and biophysical mechanism involved in the regulation of MS channel activities is a central interest in basic biology. MS channels are thought to play crucial roles in gravity sensing in plant cells. To date, two mechanisms have been proposed for MS channel activation. One is that tension development in the lipid bilayer directly activates MS channels. The second mechanism proposes that the cytoskeleton is involved in the channel activation, because MS channel activities are modulated by pharmacological treatments that affect the cytoskeleton. We tested whether tension in the cytoskeleton activates MS channels. Mammalian endothelial cells were microinjected with phalloidin-conjugated beads, which bound to stress fibres, and a traction force to the actin cytoskeleton was applied by dragging the beads with optical tweezers. MS channels were activated when the force was applied, demonstrating that a sub-p N force to the actin filaments activates a single MS channel. Plants may use a similar molecular mechanism in gravity sensing, since the cytoplasmic Ca2+ concentration increase induced by changes in the gravity vector was attenuated by potential MS channel inhibitors, and by actin-disrupting drugs. These results support the idea that the tension increase in actin filaments by gravity-dependent sedimentation of amyloplasts activates MS Ca2+-permeable channels, which can be the molecular mechanism of a Ca2+ concentration increase through gravistimulation. We review recent progress in the study of tension sensing by actin filaments and MS channels using advanced biophysical methods, and discuss their possible roles in gravisensing. [ABSTRACT FROM AUTHOR]

Published
2014
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422. Impaired free fatty acid uptake in skeletal muscle but not in myocardium in patients with impaired glucose tolerance: studies with PET and 14(R,S)-[18F]fluoro-6-thia-heptadecanoic acid.

Author

Turpeinen, A K, primary, Takala, T O, additional, Nuutila, P, additional, Axelin, T, additional, Luotolahti, M, additional, Haaparanta, M, additional, Bergman, J, additional, Hämäläinen, H, additional, Iida, H, additional, Mäki, M, additional, Uusitupa, M I, additional, and Knuuti, J, additional

Published
1999
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436. Coronary flow reserve is reduced in young men with IDDM

Author

Pitkanen, O. P., primary, Nuutila, P., additional, Raitakari, O. T., additional, Ronnemaa, T., additional, Koskinen, P. J., additional, Iida, H., additional, Lehtimaki, T. J., additional, Laine, H. K., additional, Takala, T., additional, Viikari, J. S., additional, and Knuuti, J., additional

Published
1998
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450. Evidence for dissociation of insulin stimulation of blood flow and glucose uptake in human skeletal muscle: studies using [15O]H2O, [18F]fluoro-2-deoxy-D-glucose, and positron emission tomography

Author

Raitakari, M., primary, Nuutila, P., additional, Ruotsalainen, U., additional, Laine, H., additional, Teras, M., additional, Iida, H., additional, Makimattila, S., additional, Utriainen, T., additional, Oikonen, V., additional, Sipila, H., additional, Haaparanta, M., additional, Solin, O., additional, Wegelius, U., additional, Knuuti, J., additional, and Yki-Jarvinen, H., additional

Published
1996
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