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3,649 results on '"Hui Zhen"'

401. Supplementary Figures and Figure Legends from Reciprocal Network between Cancer Stem-Like Cells and Macrophages Facilitates the Progression and Androgen Deprivation Therapy Resistance of Prostate Cancer

Author

Ying-Hao Sun, Xin-Gang Cui, Dan-Feng Xu, Chuan-Liang Xu, Dan Liu, Qin-Qin Tian, Yan-Qiong Cheng, Ze-Yu Yang, Jun Yang, Zhe Zhou, Kai-Jian Wang, Li-He Dai, Min Qu, De-Pei Kong, Hong-Ru Wang, Ke-Qin Dong, Xu Gao, Guang Peng, Hui-Zhen Li, Fei Liu, Chao Wang, and Hai Huang

Abstract

Supplementary Figures and Figure Legends

Published
2023
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402. RAGA prevents tumor immune evasion of LUAD by promoting CD47 lysosome degradation

Author

Lian Zhang, Jing Yu, Mingyue Zheng, Hui Zhen, Qingqiang Xie, Chundong Zhang, Zhongjun Zhou, and Guoxiang Jin

Subjects
Medicine (miscellaneous), General Agricultural and Biological Sciences, General Biochemistry, Genetics and Molecular Biology
Abstract

CD47 is a macrophage-specific immune checkpoint protein acting by inhibiting phagocytosis. However, the underlying mechanism maintaining CD47 protein stability in cancer is not clear. Here we show that CD47 undergoes degradation via endocytosis/lysosome pathway. The lysosome protein RAGA interacts with and promotes CD47 lysosome localization and degradation. Disruption of RAGA blocks CD47 degradation, leading to CD47 accumulation, high plasma membrane/intracellular CD47 expression ratio and reduced phagocytic clearance of cancer cells. RAGA deficiency promotes tumor growth due to the accumulation of CD47, which sensitizes the tumor to CD47 blockade. Clinical analysis shows that RAGA and CD47 proteins are negatively correlated in lung adenocarcinoma patient samples. High RAGA protein level is related to longer patient survival. In addition, RAGAhighCD47low patients show the longest overall survival. Our study thereby not only reveals a mechanism by which RAGA regulates CD47 lysosome degradation, but also suggests RAGA is a potential diagnostic biomarker of lung adenocarcinoma.

Published
2023
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403. Ibrutinib facilitates the sensitivity of colorectal cancer cells to ferroptosis through BTK/NRF2 pathway

Author

Jin-Feng Zhu, Yi Liu, Wen-Ting Li, Ming-Hui Li, Chao-Hui Zhen, Pei-Wei Sun, Ji-Xin Chen, Wen-Hao Wu, and Wei Zeng

Subjects
Cancer Research, Cellular and Molecular Neuroscience, Immunology, Cell Biology
Abstract

Ibrutinib is a drug that inhibits the protein Burton’s tyrosine kinase and thereby the nuclear translocation of Nrf2, which played a key role in mediating the activation of antioxidants during stress conditions and ferroptosis resistance. This study aimed to identify the effect of Ibrutinib and ferroptosis inducer on colorectal cancer (CRC) treatment and its underlying mechanism. In our study, we found the upregulation of Nrf2 was correlated with CRC progression and antioxidant proteins. Ibrutinib sensitized CRC to ferroptosis inducers, suggested by further reduced CRC cell viability, proliferation and decreased antioxidant protein levels in CRC cells after combination treatment of Ibrutinib and RSL3 or Ibrutinib and Erastin both in vivo and in vitro. Knockout of Nrf2 diminished the regulatory effect of Ibrutinib on CRC sensitivity to ferroptosis inducers. Altogether, this study demonstrated that Ibrutinib increases the sensitivity of CRC cell to ferroptosis inducers by inhibiting Nrf2.

Published
2023
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406. Ophiopogon sclerophyllus, a new species of Ophiopogon (Asparagaceae) from Guangxi, China

Author

DONG-XIN NONG, HUI-ZHEN LÜ, XUE-YAN HUANG, and BAO-YOU HUANG

Subjects
Tracheophyta, Liliopsida, Asparagales, Plant Science, Biodiversity, Plantae, Ecology, Evolution, Behavior and Systematics, Taxonomy, Asparagaceae
Abstract

Ophiopogon sclerophyllus is described and illustrated as a new species from northwestern Guangxi, China. The new species can be distinguished from other Ophiopogon species by its roots with fusiform or oblong tubercles near middle or tip, thickly leathery leaf blade, widely opening flowers with recurved perianth segments. The relationships among O. sclerophyllus, O. pseudotonkinensis and O. petraeus are shortly discussed.

Published
2023

407. Fluorescent Self-Reporting Lipid Nanoparticles for Nitric Oxide/Gene Co-Delivery and Combination Therapy

Author

Hui-Zhen Yang, Yu Guo, Lin Pu, Xiao-Qi Yu, and Ji Zhang

Subjects
Drug Discovery, Pharmaceutical Science, Molecular Medicine
Abstract

The combination cancer therapy of nitric oxide (NO) with gene therapy is a promising method for tumor treatment. However, efficient co-delivery of gas and therapeutic genes to tumor cells remains a challenge. Herein, we designed a nano-sized ultraviolet (UV) light-responsive cationic lipid vector

Published
2023

413. Supplementary Figures S1-8 from SPON2 Promotes M1-like Macrophage Recruitment and Inhibits Hepatocellular Carcinoma Metastasis by Distinct Integrin–Rho GTPase–Hippo Pathways

Author

Zhang, Yan-Li, primary, Li, Qing, primary, Yang, Xiao-Mei, primary, Fang, Fang, primary, Li, Jun, primary, Wang, Ya-Hui, primary, Yang, Qin, primary, Zhu, Lei, primary, Nie, Hui-Zhen, primary, Zhang, Xue-Li, primary, Feng, Ming-Xuan, primary, Jiang, Shu-Heng, primary, Tian, Guang-Ang, primary, Hu, Li-Peng, primary, Lee, Ho-Young, primary, Lee, Su-Jae, primary, Xia, Qiang, primary, and Zhang, Zhi-Gang, primary

Published
2023
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414. Supplementary Figures and Figure Legends from Reciprocal Network between Cancer Stem-Like Cells and Macrophages Facilitates the Progression and Androgen Deprivation Therapy Resistance of Prostate Cancer

Author

Huang, Hai, primary, Wang, Chao, primary, Liu, Fei, primary, Li, Hui-Zhen, primary, Peng, Guang, primary, Gao, Xu, primary, Dong, Ke-Qin, primary, Wang, Hong-Ru, primary, Kong, De-Pei, primary, Qu, Min, primary, Dai, Li-He, primary, Wang, Kai-Jian, primary, Zhou, Zhe, primary, Yang, Jun, primary, Yang, Ze-Yu, primary, Cheng, Yan-Qiong, primary, Tian, Qin-Qin, primary, Liu, Dan, primary, Xu, Chuan-Liang, primary, Xu, Dan-Feng, primary, Cui, Xin-Gang, primary, and Sun, Ying-Hao, primary

Published
2023
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415. Data from SPON2 Promotes M1-like Macrophage Recruitment and Inhibits Hepatocellular Carcinoma Metastasis by Distinct Integrin–Rho GTPase–Hippo Pathways

Author

Zhang, Yan-Li, primary, Li, Qing, primary, Yang, Xiao-Mei, primary, Fang, Fang, primary, Li, Jun, primary, Wang, Ya-Hui, primary, Yang, Qin, primary, Zhu, Lei, primary, Nie, Hui-Zhen, primary, Zhang, Xue-Li, primary, Feng, Ming-Xuan, primary, Jiang, Shu-Heng, primary, Tian, Guang-Ang, primary, Hu, Li-Peng, primary, Lee, Ho-Young, primary, Lee, Su-Jae, primary, Xia, Qiang, primary, and Zhang, Zhi-Gang, primary

Published
2023
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416. Supplementary materials and methods from SPON2 Promotes M1-like Macrophage Recruitment and Inhibits Hepatocellular Carcinoma Metastasis by Distinct Integrin–Rho GTPase–Hippo Pathways

Author

Zhang, Yan-Li, primary, Li, Qing, primary, Yang, Xiao-Mei, primary, Fang, Fang, primary, Li, Jun, primary, Wang, Ya-Hui, primary, Yang, Qin, primary, Zhu, Lei, primary, Nie, Hui-Zhen, primary, Zhang, Xue-Li, primary, Feng, Ming-Xuan, primary, Jiang, Shu-Heng, primary, Tian, Guang-Ang, primary, Hu, Li-Peng, primary, Lee, Ho-Young, primary, Lee, Su-Jae, primary, Xia, Qiang, primary, and Zhang, Zhi-Gang, primary

Published
2023
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417. Supplementary Tables S1-3 from SPON2 Promotes M1-like Macrophage Recruitment and Inhibits Hepatocellular Carcinoma Metastasis by Distinct Integrin–Rho GTPase–Hippo Pathways

Author

Zhang, Yan-Li, primary, Li, Qing, primary, Yang, Xiao-Mei, primary, Fang, Fang, primary, Li, Jun, primary, Wang, Ya-Hui, primary, Yang, Qin, primary, Zhu, Lei, primary, Nie, Hui-Zhen, primary, Zhang, Xue-Li, primary, Feng, Ming-Xuan, primary, Jiang, Shu-Heng, primary, Tian, Guang-Ang, primary, Hu, Li-Peng, primary, Lee, Ho-Young, primary, Lee, Su-Jae, primary, Xia, Qiang, primary, and Zhang, Zhi-Gang, primary

Published
2023
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418. Supplementary Tables from Reciprocal Network between Cancer Stem-Like Cells and Macrophages Facilitates the Progression and Androgen Deprivation Therapy Resistance of Prostate Cancer

Author

Huang, Hai, primary, Wang, Chao, primary, Liu, Fei, primary, Li, Hui-Zhen, primary, Peng, Guang, primary, Gao, Xu, primary, Dong, Ke-Qin, primary, Wang, Hong-Ru, primary, Kong, De-Pei, primary, Qu, Min, primary, Dai, Li-He, primary, Wang, Kai-Jian, primary, Zhou, Zhe, primary, Yang, Jun, primary, Yang, Ze-Yu, primary, Cheng, Yan-Qiong, primary, Tian, Qin-Qin, primary, Liu, Dan, primary, Xu, Chuan-Liang, primary, Xu, Dan-Feng, primary, Cui, Xin-Gang, primary, and Sun, Ying-Hao, primary

Published
2023
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419. Exogenous Application of Multi-Walled Carbon Nanotubes (MWCNTs) and Nano-Selenium (Nano-Se) Alleviated the PEG-Induced Water Deficit Stress and Improved the Crop Performance of Camelina

Author

Wu, Hui-Zhen, primary, Gao, Yang, additional, Zhang, Youxin, additional, Yu, Jialin, additional, Kim, Do-Soon, additional, Chen, Min, additional, Wang, Yawen, additional, Fan, Yi, additional, Zhang, Haixi, additional, Yan, Xuebing, additional, and Zhang, Chuan-Jie, additional

Published
2023
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421. CCBE1 promotes mitochondrial fusion by inhibiting the TGFβ-DRP1 axis to prevent the progression of hepatocellular carcinoma

Author

Tian, Guang-Ang, primary, Xu, Wen-Ting, additional, Zhang, Xue-Li, additional, Zhou, Yao-Qi, additional, Sun, Yue, additional, Hu, Li-Peng, additional, Jiang, Shu-Heng, additional, Nie, Hui-Zhen, additional, Zhang, Zhi-Gang, additional, Zhu, Lei, additional, Li, Jun, additional, Yang, Xiao-Mei, additional, and Yao, Lin-Li, additional

Published
2023
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428. The impact of depression and anxiety on the risk of exacerbation in adults with bronchiectasis: a prospective cohort study

Author

Gao, Yong-Hua, primary, Zheng, Hui-Zhen, additional, Lu, Hai-Wen, additional, Li, Yuan-Yuan, additional, Feng, Yun, additional, Mao, Bei, additional, Bai, Jiu-Wu, additional, Liang, Shuo, additional, Cheng, Ke-Bin, additional, Gu, Shu-yi, additional, Sun, Xiao-Li, additional, Li, Jian-Xiong, additional, Ge, Ai, additional, Li, Man-Hui, additional, Yang, Jia-Wei, additional, Bai, Lu, additional, Yu, Han-Yu, additional, Qu, Jie-Ming, additional, and Xu, Jin-Fu, additional

Published
2023
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436. Factors Affecting the Recurrence of Giant Cell Tumor of Bone After Surgery: A Clinicopathological Study of 80 Cases from a Single Center

Author

Dong-dong Cheng, Tu Hu, Hui-zhen Zhang, Jin Huang, and Qing-cheng Yang

Subjects
Surgery, Campanacci grade, GCTB, CD147, Physiology, QP1-981, Biochemistry, QD415-436
Abstract

Background/Aims: This aim of the present study was to identify specific markers determining the recurrence of the giant cell tumor of bone (GCTB). Methods: This study involved the clinicopathological analysis of 80 cases. All of the clinical features, pathological fracture, Campanacci grade, histological features and surgical methods were reviewed. Immunohistochemistry was used to detect the expression of Ki-67, CD147, mutant p53 and p63 in GCTB. Comparisons between different groups were performed using the Chi-square test. The risk factors affecting recurrence were analyzed using a binary logistic model. Kaplan-Meier analysis was employed for the survival analysis between the groups. Cell proliferation assays, migration and invasion assays were used to detect the function of CD147 on GCTB in vitro. Results: The univariate analysis showed that Ki-67 and CD147 expression, pathological fracture, Campanacci grade and surgical method were associated with recurrence. The multivariate analysis revealed that CD147 expression, Campanacci grade and surgical method were the factors affecting GCTB recurrence. In addition, the Kaplan-Meier analysis revealed that these factors affected tumor-free survival time. In vitro study revealed that the CD147 knockdown by small interfering RNA (siRNA) technique dramatically reduced the proliferation, migration and invasion of GCTB. Conclusion: Our results suggest that CD147 may serve as an adequate marker for GCTB recurrence. Campanacci grade is a risk factor for GCTB recurrence, which is also affected by the surgical method used.

Published
2015
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444. Optimal Waist Circumference Cut-off values for Identifying Metabolic Risk Factors in Middle-aged and Elderly Subjects in Shandong Province of China

Author

HOU, Xin Guo, WANG, Chuan, MA, Ze Qiang, YANG, Wei Fang, WANG, Ji Xiang, LI, Cheng Qiao, WANG, Yu Lian, LIU, Shu Min, Hu, Xiu Ping, ZHANG, Xiu Ping, JIANG, Mei, WANG, Wei Qing, NING, Guang, ZHENG, Hui Zhen, MA, Ai Xia, SUN, Yu, SONG, Jun, LIN, Peng, LIANG, Kai, LIU, Fu Qiang, LI, Wen Juan, XIAO, Juan, GONG, Lei, WANG, Mei Jian, LIU, Ji Dong, YAN, Fei, YANG, Jun Peng, WANG, Ling Shu, TIAN, Meng, ZHAO, Ru Xing, JIANG, Ling, and CHEN, Li

Published
2014
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