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401. Tracking the Race Between Deep Reinforcement Learning and Imitation Learning -- Extended Version

Author

Gros, Timo P., Höller, Daniel, Hoffmann, Jörg, and Wolf, Verena

Subjects
Computer Science - Machine Learning, Computer Science - Artificial Intelligence
Abstract

Learning-based approaches for solving large sequential decision making problems have become popular in recent years. The resulting agents perform differently and their characteristics depend on those of the underlying learning approach. Here, we consider a benchmark planning problem from the reinforcement learning domain, the Racetrack, to investigate the properties of agents derived from different deep (reinforcement) learning approaches. We compare the performance of deep supervised learning, in particular imitation learning, to reinforcement learning for the Racetrack model. We find that imitation learning yields agents that follow more risky paths. In contrast, the decisions of deep reinforcement learning are more foresighted, i.e., avoid states in which fatal decisions are more likely. Our evaluations show that for this sequential decision making problem, deep reinforcement learning performs best in many aspects even though for imitation learning optimal decisions are considered., Comment: Extended Version of the Conference Paper published in the Proceedings of the 17th International Conference on Quantitative Evaluation of SysTems (QEST)

Published
2020

402. R2D2 spherical TPC: first energy resolution results

Author

Bouet, R., Busto, J., Cecchini, V., Cerna, C., Dastgheibi-Fard, A., Druillole, F., Jollet, C., Hellmuth, P., Katsioulas, I., Knights, P., Giomataris, I., Gros, M., Lautridou, P., Meregaglia, A., Navick, X. F., Neep, T., Nikolopoulos, K., Perrot, F., Piquemal, F., Roche, M., Thomas, B., Ward, R., and Zampaolo, M.

Subjects
Physics - Instrumentation and Detectors
Abstract

Spherical time projection chambers (TPC), also known as spherical proportional counters, are employed in the search for rare phenomena, such as light Dark Matter candidates. The spherical TPC exhibits a number of essential features, making it a promising candidate for the search of neutrinoless double beta decay ($\beta\beta0\nu$). A tonne-scale spherical TPC experiment could cover a region of parameter space relevant for the inverted mass hierarchy with a few years of data taking. In this direction, the major R\&D goal of the R2D2 effort is the demonstration of the required energy resolution. First results from an argon-filled prototype detector are reported, demonstrating an energy resolution of 1.1\% FWHM for 5.3~MeV $\alpha$ tracks in the 0.2 to 1.1~bar pressure range. This is a major milestone in terms of energy resolution, paving the way for further studies with xenon gas, and the possible use of this technology for $\beta\beta0\nu$ searches.

Published
2020
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403. Covering classes and $1$-tilting cotorsion pairs over commutative rings

Author

Bazzoni, Silvana and Gros, Giovanna Le

Subjects
Mathematics - Commutative Algebra
Abstract

We are interested in characterising the commutative rings for which a $1$-tilting cotorsion pair $(\mathcal{A}, \mathcal{T})$ provides for covers, that is when the class $\mathcal{A}$ is a covering class. We use Hrbek's bijective correspondence between the $1$-tilting cotorsion pairs over a commutative ring $R$ and the faithful finitely generated Gabriel topologies on $R$. Moreover, we use results of Bazzoni-Positselski, in particular a generalisation of Matlis equivalence and their characterisation of covering classes for $1$-tilting cotorsion pairs arising from flat injective ring epimorphisms. Explicitly, if $\mathcal{G}$ is the Gabriel topology associated to the $1$-tilting cotorsion pair $(\mathcal{A}, \mathcal{T})$, and $R_\mathcal{G}$ is the ring of quotients with respect to $\mathcal{G}$, we show that if $\mathcal{A}$ is covering then $\mathcal{G}$ is a perfect localisation (in Stenstr\"om's sense) and the localisation $R_\mathcal{G}$ has projective dimension at most one. Moreover, we show that $\mathcal{A}$ is covering if and only if both the localisation $R_\mathcal{G}$ and the quotient rings $R/J$ are perfect rings for every $J \in \mathcal{G}$. Rings satisfying the latter two conditions are called $\mathcal{G}$-almost perfect., Comment: This paper is a follow-up to the authors' paper "Enveloping classes over commutative rings'', whereas the authors' paper "$\mathcal{P}_1$-covers over commutative rings'' considers cotorsion pairs not necessarily of finite type

Published
2020

404. Self induced class stratification in competitive societies of agents: Nash stability in the presence of envy

Author

Gros, Claudius

Subjects
Physics - Physics and Society, Nonlinear Sciences - Adaptation and Self-Organizing Systems
Abstract

Envy, the inclination to compare rewards, can be expected to unfold when inequalities in terms of payoff differences are generated in competitive societies. It is shown that increasing levels of envy lead inevitably to a self-induced separation into a lower and an upper class. Class stratification is Nash stable and strict, with members of the same class receiving identical rewards. Upper class agents play exclusively pure strategies, all lower class agents the same mixed strategy. The fraction of upper class agents decreases progressively with larger levels of envy, until a single upper class agent is left. Numerical simulations and a complete analytic treatment of a basic reference model, the shopping trouble model, are presented. The properties of the class-stratified society are universal and only indirectly controllable through the underlying utility function, which implies that class stratified societies are intrinsically resistant to political control. Implications for human societies are discussed. It is pointed out that the repercussions of envy are amplified when societies become increasingly competitive., Comment: Royal Society Open Science, in press

Published
2020
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405. Reinforcement Learning Based on Real-Time Iteration NMPC

Author

Zanon, Mario, Kungurtsev, Vyacheslav, and Gros, Sébastien

Subjects
Electrical Engineering and Systems Science - Systems and Control
Abstract

Reinforcement Learning (RL) has proven a stunning ability to learn optimal policies from data without any prior knowledge on the process. The main drawback of RL is that it is typically very difficult to guarantee stability and safety. On the other hand, Nonlinear Model Predictive Control (NMPC) is an advanced model-based control technique which does guarantee safety and stability, but only yields optimality for the nominal model. Therefore, it has been recently proposed to use NMPC as a function approximator within RL. While the ability of this approach to yield good performance has been demonstrated, the main drawback hindering its applicability is related to the computational burden of NMPC, which has to be solved to full convergence. In practice, however, computationally efficient algorithms such as the Real-Time Iteration (RTI) scheme are deployed in order to return an approximate NMPC solution in very short time. In this paper we bridge this gap by extending the existing theoretical framework to also cover RL based on RTI NMPC. We demonstrate the effectiveness of this new RL approach with a nontrivial example modeling a challenging nonlinear system subject to stochastic perturbations with the objective of optimizing an economic cost., Comment: accepted for the IFAC World Congress 2020

Published
2020

406. Twisted differential operators and $q$-crystals

Author

Gros, Michel, Stum, Bernard Le, and Quirós, Adolfo

Subjects
Mathematics - Algebraic Geometry, 14F30, 14F40
Abstract

We discuss the notion of a q-PD-envelope considered by Bhatt and Scholze in their recent theory of q-crystalline cohomology and explain the relation with our notion of a divided polynomial twisted algebra. Together with an interpretation of crystals on the q-crystalline site, that we call q-crystals, as modules endowed with some kind of stratification, it allows us to associate a module on the ring of twisted differential operators to any q-crystal. For simplicity, we explain here only the one dimensional case.

Published
2020

407. Combining system identification with reinforcement learning-based MPC

Author

Martinsen, Andreas B., Lekkas, Anastasios M., and Gros, Sebastien

Subjects
Electrical Engineering and Systems Science - Systems and Control
Abstract

In this paper we propose and compare methods for combining system identification (SYSID) and reinforcement learning (RL) in the context of data-driven model predictive control (MPC). Assuming a known model structure of the controlled system, and considering a parametric MPC, the proposed approach simultaneously: a) Learns the parameters of the MPC using RL in order to optimize performance, and b) fits the observed model behaviour using SYSID. Six methods that avoid conflicts between the two optimization objectives are proposed and evaluated using a simple linear system. Based on the simulation results, hierarchical, parallel projection, nullspace projection, and singular value projection achieved the best performance., Comment: Accepted to the IFAC2020

Published
2020

408. Reinforcement Learning for Mixed-Integer Problems Based on MPC

Author

Gros, Sebastien and Zanon, Mario

Subjects
Electrical Engineering and Systems Science - Systems and Control, Computer Science - Artificial Intelligence, Computer Science - Machine Learning
Abstract

Model Predictive Control has been recently proposed as policy approximation for Reinforcement Learning, offering a path towards safe and explainable Reinforcement Learning. This approach has been investigated for Q-learning and actor-critic methods, both in the context of nominal Economic MPC and Robust (N)MPC, showing very promising results. In that context, actor-critic methods seem to be the most reliable approach. Many applications include a mixture of continuous and integer inputs, for which the classical actor-critic methods need to be adapted. In this paper, we present a policy approximation based on mixed-integer MPC schemes, and propose a computationally inexpensive technique to generate exploration in the mixed-integer input space that ensures a satisfaction of the constraints. We then propose a simple compatible advantage function approximation for the proposed policy, that allows one to build the gradient of the mixed-integer MPC-based policy., Comment: Accepted at IFAC 2020

Published
2020

409. Safe Reinforcement Learning via Projection on a Safe Set: How to Achieve Optimality?

Author

Gros, Sebastien, Zanon, Mario, and Bemporad, Alberto

Subjects
Electrical Engineering and Systems Science - Systems and Control, Computer Science - Artificial Intelligence, Computer Science - Machine Learning
Abstract

For all its successes, Reinforcement Learning (RL) still struggles to deliver formal guarantees on the closed-loop behavior of the learned policy. Among other things, guaranteeing the safety of RL with respect to safety-critical systems is a very active research topic. Some recent contributions propose to rely on projections of the inputs delivered by the learned policy into a safe set, ensuring that the system safety is never jeopardized. Unfortunately, it is unclear whether this operation can be performed without disrupting the learning process. This paper addresses this issue. The problem is analysed in the context of $Q$-learning and policy gradient techniques. We show that the projection approach is generally disruptive in the context of $Q$-learning though a simple alternative solves the issue, while simple corrections can be used in the context of policy gradient methods in order to ensure that the policy gradients are unbiased. The proposed results extend to safe projections based on robust MPC techniques., Comment: Accepted at IFAC 2020

Published
2020

410. Automatic segmentation of spinal multiple sclerosis lesions: How to generalize across MRI contrasts?

Author

Vincent, Olivier, Gros, Charley, Cohen, Joseph Paul, and Cohen-Adad, Julien

Subjects
Electrical Engineering and Systems Science - Image and Video Processing, Computer Science - Computer Vision and Pattern Recognition, Computer Science - Machine Learning
Abstract

Despite recent improvements in medical image segmentation, the ability to generalize across imaging contrasts remains an open issue. To tackle this challenge, we implement Feature-wise Linear Modulation (FiLM) to leverage physics knowledge within the segmentation model and learn the characteristics of each contrast. Interestingly, a well-optimised U-Net reached the same performance as our FiLMed-Unet on a multi-contrast dataset (0.72 of Dice score), which suggests that there is a bottleneck in spinal MS lesion segmentation different from the generalization across varying contrasts. This bottleneck likely stems from inter-rater variability, which is estimated at 0.61 of Dice score in our dataset., Comment: Presented at OHBM 2020 (v2-3 : corrected typos)

Published
2020

411. Les suites spectrales de Hodge-Tate

Author

Abbes, Ahmed and Gros, Michel

Subjects
Mathematics - Algebraic Geometry, Mathematics - Number Theory
Abstract

This book presents two important results in p-adic Hodge theory following the approach initiated by Faltings, namely (i) his main p-adic comparison theorem, and (ii) the Hodge-Tate spectral sequence. We establish for each of these results two versions, an absolute one and a relative one. While the absolute statements can reasonably be considered as well understood, particularly after their extension to rigid varieties by Scholze, Faltings' initial approach for the relative variants has remained much less studied. Although we follow the same strategy as that used by Faltings to establish his main p-adic comparison theorem, part of our proofs is based on new results. The relative Hodge-Tate spectral sequence is new in this approach., Comment: 411 page. in French language. Final version. The starting point of this work is our preprint arXiv:1509.03617 which is included in this monograph

Published
2020
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412. The relative Hodge-Tate spectral sequence -- an overview

Author

Abbes, Ahmed and Gros, Michel

Subjects
Mathematics - Algebraic Geometry, Mathematics - Number Theory
Abstract

We give in this note an overview of a recent work leading to a generalization of the Hodge-Tate spectral sequence to morphisms. The latter takes place in Faltings topos, but its construction requires the introduction of a relative variant of this topos which is the main novelty of our work., Comment: 13 pages

Published
2020

413. A resistive ACHINOS multi-anode structure with DLC coating for spherical proportional counters

Author

Giomataris, I., Gros, M., Katsioulas, I., Knights, P., Mols, J. -P., Neep, T., Nikolopoulos, K., Savvidis, G., Savvidis, I., Shang, L., Ward, R., and Zhou, Y.

Subjects
Physics - Instrumentation and Detectors
Abstract

The spherical proportional counter is a gaseous detector used in a variety of applications, including direct dark matter and neutrino-less double beta decay searches. The ACHINOS multianode structure is a read-out technology that overcomes the limitations of single-anode read-out structures for large-size detectors and operation under high pressure. A resistive ACHINOS is presented, where the 3D printed central component is coated in a Diamond-Like Carbon (DLC) layer. The production and testing of the structure, in terms of stability and resolution, is described. Further applications in fundamental physics and industry are also discussed., Comment: 8 pages, 8 figures

Published
2020
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414. First germanium-based constraints on sub-MeV Dark Matter with the EDELWEISS experiment

Author

EDELWEISS Collaboration, Arnaud, Q., Armengaud, E., Augier, C., Benoît, A., Bergé, L., Billard, J., Broniatowski, A., Camus, P., Cazes, A., Chapellier, M., Charlieux, F., De Jésus, M., Dumoulin, L., Eitel, K., Elkhoury, E., Fillipini, J. -B., Filosofov, D., Gascon, J., Giuliani, A., Gros, M., Jin, Y., Juillard, A., Kleifges, M., Lattaud, H., Marnieros, S., Misiak, D., Navick, X. -F., Nones, C., Olivieri, E., Oriol, C., Pari, P., Paul, B., Poda, D., Rozov, S., Salagnac, T., Sanglard, V., Siebenborn, B., Vagneron, L., Weber, M., Yakushev, E., and Zolotarova, A.

Subjects
Astrophysics - Astrophysics of Galaxies, Astrophysics - Instrumentation and Methods for Astrophysics, Physics - Instrumentation and Detectors
Abstract

The EDELWEISS collaboration has performed a search for Dark Matter (DM) particles interacting with electrons using a 33.4 g Ge cryogenic detector operated underground at the LSM. A charge resolution of 0.53 electron-hole pairs (RMS) has been achieved using the Neganov-Trofimov-Luke amplification with a bias of 78 V. We set the first Ge-based constraints on sub-MeV/c$^{2}$ DM particles interacting with electrons, as well as on dark photons down to 1 eV/c$^2$. These are competitive with other searches. In particular, new limits are set on the kinetic mixing of dark photon DM in a so far unconstrained parameter space region in the 6 to 9 eV/c$^2$ mass range. These results demonstrate the high relevance of cryogenic Ge detectors for the search of DM interactions producing eV-scale electron signals., Comment: 6 pages, 4 figures, corrected typos

Published
2020
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415. $\mathcal{P}_1$-covers over commutative rings

Author

Bazzoni, Silvana and Gros, Giovanna Le

Subjects
Mathematics - Commutative Algebra
Abstract

In this paper we consider the class $\mathcal{P}_1(R)$ of modules of projective dimension at most one over a commutative ring $R$ and we investigate when $\mathcal{P}_1(R)$ is a covering class. More precisely, we investigate Enochs' Conjecture for this class, that is the question of whether $\mathcal{P}_1(R)$ is covering necessarily implies that $\mathcal{P}_1(R)$ is closed under direct limits. We answer the question affirmatively in the case of a commutative semihereditary ring $R$. This gives an example of a cotorsion pair $(\mathcal{P}_1(R), \mathcal{P}_1(R)^\perp)$ which is not necessarily of finite type such that $\mathcal{P}_1(R)$ satisfies Enochs' Conjecture. Moreover, we describe the class $\varinjlim \mathcal{P}_1(R)$ over (not-necessarily commutative) rings which admit a classical ring of quotients.

Published
2020

416. Research Directions in Cyber Threat Intelligence

Author

Groš, Stjepan

Subjects
Computer Science - Cryptography and Security
Abstract

Cyber threat intelligence is a relatively new field that has grown from two distinct fields, cyber security and intelligence. As such, it draws knowledge from and mixes the two fields. Yet, looking into current scientific research on cyber threat intelligence research, it is relatively scarce, which opens up a lot of opportunities. In this paper we define what cyber threat intelligence is, briefly review some aspects for cyber threat intelligence. Then, we analyze existing research fields that are much older that cyber threat intelligence but related to it. This opens up an opportunity to draw knowledge and methods from those older field, and in that way advance cyber threat intelligence much faster than it would by following its own path. With such an approach we effectively give a research directions for CTI., Comment: 6 pages

Published
2020

417. End-user experience with the SCoTSS Compton imager and directional survey spectrometer

Author

Sinclair, Laurel E., McCann, Andrew, Saull, Patrick R. B., Mantifel, Rodger L., Ouellet, Christian V. O., Drouin, Pierre-Luc, Macleod, Audrey M. L., Gros, Brian Le, Summerell, Ian, Hovgaard, Jens H., Monkhouse, Stephen, Stanescu, Flaviu, Jonkmans, Guy, and Murtha, Nathan

Subjects
Physics - Instrumentation and Detectors, Physics - Applied Physics
Abstract

The Silicon photomultiplier-based Compton Telescope for Safety and Security (SCoTSS) has been developed incorporating end-user requirements into the design process. The end-user group includes those responsible for mobile survey in the event of a radiological or nuclear accident, those responsible for radiation survey support to security operations at major events and at Canadian borders, as well as some of those responsible for Canadian defense applications. The SCoTSS development program has reached a technology readiness level of eight, and we are proceeding with field trials of the instrument in high-fidelity operational environments. Prospective end users have been involved in trial set up and execution, assuring applicability in their mission spaces. SCoTSS has been subject to trials involving hidden sources, heavily shielded sources, imager moving with respect to source, and complicated man-made surroundings. Our operators value high sensitivity for anomaly geolocation and mapping. End users also require an instrument which is capable of direction reconstruction in motion, as well as rapid imaging of a field of view. We have developed a "time to image" measure which allows for quantitative comparison of imagers of fundamentally different technology, where one design may have an advantage in terms of energy resolution and compactness and another design may have an advantage in terms of efficiency and cost effectiveness. We present here the performance of the SCoTSS imager in rapid direction finding. As well, we compare the time to image quantity for the SCoTSS imager and the H3D Polaris-H Quad imager where the data were taken under equivalent conditions. This quantitative measure of imaging performance can allow operators to make an informed choice of the design that meets their needs taking into consideration also weight and size as well as budgetary constraints., Comment: 19 pages, 8 figures

Published
2020
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419. Crossing barriers: the burden of inflammatory bowel disease across Western Europe

Author

Aditi Kumar, Nuha Yassin, Alexandra Marley, Vittoria Bellato, Caterina Foppa, Gianluca Pellino, Pär Myrelid, Monica Millan, Beatriz Gros, Nicolas Avellaneda, Ignacio Catalan-Serra, Alaa El-Hussuna, João A. Cunha Neves, Joana Roseira, Miguel F. Cunha, Bram Verstockt, Dominik Bettenworth, Diane Mege, and Matthew J. Brookes

Subjects
Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

An estimated 2.5–3 million individuals (0.4%) in Europe are affected by inflammatory bowel disease (IBD). Whilst incidence rates for IBD are stabilising across Europe, the prevalence is rising and subsequently resulting in a significant cost to the healthcare system of an estimated 4.6–5.6 billion euros per year. Hospitalisation and surgical resection rates are generally on a downward trend, which is contrary to the rising cost of novel medication. This signifies a large part of healthcare cost and burden. Despite publicly funded healthcare systems in most European countries, there is still wide variation in how patients receive and/or pay for biologic medication. This review will provide an overview and discuss the different healthcare systems within Western Europe and the barriers that affect overall management of a changing IBD landscape, including differences to hospitalisation and surgical rates, access to medication and clinical trial participation and recruitment. This review will also discuss the importance of standardising IBD management to attain high-quality care for all patients with IBD.

Published
2023
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420. Post-transplant survival with pre-transplant durable continuous-flow mechanical circulatory support in a Swiss cohort of heart transplant recipients

Author

Roger Hullin, Tamila Abdurashidova, Barbara Pitta-Gros, Sara Schukraft, Valentina Rancati, Henri Lu, Anouck Zurbuchen, Carlo Marcucci, Zaid Ltaief, Karl Lefol, Christoph Huber, Manuel Pascual, Piergiorgio Tozzi, Philippe Meyer, and Matthias Kirsch

Subjects
Medicine
Abstract

BACKGROUND: Worldwide, almost half of all heart transplantation candidates arrive today at their transplant operation with durable continuous-flow mechanical circulatory support (CF-MCS). This evolution is due to a progressive increase of waiting list time and hence an increased risk of haemodynamic worsening. Longer duration of CF-MCS is associated with a higher risk of device-related complications with potential adverse impact on post-transplant outcome as suggested by recent results from the United Network of Organ Sharing of the United States. METHODS: A 2-centre Swiss heart transplantation programme conducted a retrospective observational study of consecutive patients of theirs who underwent a transplant in the period 2008–2020. The primary aim was to determine whether post-transplant all-cause mortality is different between heart transplant recipients without or with pre-transplant CF-MCS. The secondary outcome was the acute cellular rejection score within the first year post-transplant. RESULTS: The study participants had a median age of 54 years; 38/158 (24%) were females. 53/158 study participants (34%) had pre-transplant CF-MCS with a median treatment duration of 280 days. In heart transplant recipients with pre-transplant CF-MCS, the prevalence of ischaemic cardiomyopathy was higher (51 vs 32%; p = 0.013), the left ventricular ejection fraction was lower (20 vs 25; p = 0.047) and pulmonary vascular resistance was higher (2.3 vs 2.1 Wood Units; p = 0.047). Over the study period, the proportion of heart transplant recipients with pre-transplant CF-MCS and the duration of pre-transplant CF-MCS treatment increased (2008–2014 vs 2015–2020: 22% vs 45%, p = 0.009; increase of treatment days per year: 34.4 ± 11.2 days, p = 0.003; respectively). The primary and secondary outcomes were not different between heart transplant recipients with pre-transplant CF-MCS or direct heart transplantation (log-rank p = 0.515; 0.16 vs 0.14, respectively; p = 0.81). CONCLUSION: This data indicates that the strategy of pre-transplant CF-MCS with subsequent orthotopic heart transplantation provides post-transplant outcomes not different to direct heart transplantation despite the fact that the duration of pre-transplant assist device treatment has progressively increased.

Published
2023
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421. Population-based birth cohort study on diabetes in pregnancy and infant hospitalisations in Cree, other First Nations and non-Indigenous communities in Quebec

Author

Nathalie Auger, Lin Xiao, Jill Torrie, Nancy Gros-Louis McHugh, Zhong-Cheng Luo, Rong Huang, Justin Cheng, and Jane Zhu

Subjects
Medicine
Abstract

Objectives Diabetes in pregnancy, whether pre-gestational (chronic) or gestational (de novo hyperglycaemia), increases the risk of adverse birth outcomes. It is unclear whether gestational diabetes increases the risk of postnatal morbidity in infants. Cree First Nations in Quebec are at high risk for diabetes in pregnancy. We assessed whether pre-gestational or gestational diabetes may increase infant hospitalisation (an infant morbidity indicator) incidence, and whether this may be related to more frequent infant hospitalisations in Cree and other First Nations in Quebec.Design Population-based birth cohort study through administrative health data linkage.Setting and participants Singleton infants (≤1 year) born to mothers in Cree (n=5070), other First Nations (9910) and non-Indigenous (48 200) communities in rural Quebec.Results Both diabetes in pregnancy and infant hospitalisation rates were much higher comparing Cree (23.7% and 29.0%) and other First Nations (12.4% and 34.1%) to non-Indigenous (5.9% and 15.5%) communities. Compared with non-diabetes, pre-gestational diabetes was associated with an increased risk of any infant hospitalisation to a greater extent in Cree and other First Nations (relative risk (RR) 1.56 (95% CI 1.28 to 1.91)) than non-Indigenous (RR 1.26 (1.15 to 1.39)) communities. Pre-gestational diabetes was associated with increased risks of infant hospitalisation due to diseases of multiple systems in all communities. There were no significant associations between gestational diabetes and risks of infant hospitalisation in all communities. The population attributable risk fraction of infant hospitalisations (overall) for pre-gestational diabetes was 6.2% in Cree, 1.6% in other First Nations and 0.3% in non-Indigenous communities.Conclusions The study is the first to demonstrate that pre-gestational diabetes increases the risk of infant hospitalisation overall and due to diseases of multiple systems, but gestational diabetes does not. High prevalence of pre-gestational diabetes may partly account for the excess infant hospitalisations in Cree and other First Nations communities in Quebec.

Published
2023
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422. Metabolic and chromosomal changes in a Bacillus subtilis whiA mutant

Author

Laura C. Bohorquez, Joana de Sousa, Transito Garcia-Garcia, Gaurav Dugar, Biwen Wang, Martijs J. Jonker, Marie-Françoise Noirot-Gros, Michael Lalk, and Leendert W. Hamoen

Subjects
WhiA, Bacillus subtilis, cell division, branched-chain fatty acids, chromosome compaction, Microbiology, QR1-502
Abstract

ABSTRACT The conserved protein WhiA is present in most Gram-positive bacteria and plays a role in cell division. WhiA contains a DNA-binding motif and is a transcription regulator of the key cell division gene ftsZ in actinomycetes. In Bacillus subtilis, the absence of WhiA influences both cell division and chromosome segregation; however, the protein does not regulate any gene involved in these processes. In this study, we addressed three alternative mechanisms by which WhiA might exert its activity in B. subtilis and examined whether WhiA influences either (i) central carbon metabolism, (ii) fatty acid composition of the cell membrane, or (iii) chromosome organization. Mutations in glycolytic enzymes have been shown to influence both cell division and DNA replication. To measure the effect of WhiA on carbon metabolism, we tested different carbon sources and measured exometabolome fluxes. This revealed that the absence of WhiA does not affect glycolysis but does influence the pool of branched-chain fatty acid precursors. Due to the effect of WhiA on chromosome segregation, we examine chromosome organization in a ∆whiA mutant using chromosome conformation capture (Hi-C) analysis. This revealed a local reduction in short-range chromosome interactions. Together, these findings provide new avenues for future research into how this protein works in the non-actinomycete firmicutes. IMPORTANCE WhiA is a conserved DNA-binding protein that influences cell division in many Gram-positive bacteria and, in B. subtilis, also chromosome segregation. How WhiA works in Bacillus subtilis is unknown. Here, we tested three hypothetical mechanisms using metabolomics, fatty acid analysis, and chromosome confirmation capture experiments. This revealed that WhiA does not influence cell division and chromosome segregation by modulating either central carbon metabolism or fatty acid composition. However, the inactivation of WhiA reduces short-range chromosome interactions. These findings provide new avenues to study the molecular mechanism of WhiA in the future.

Published
2023
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423. Driver mutations in GNAQ and GNA11 genes as potential targets for precision immunotherapy in uveal melanoma patients

Author

Sandra García-Mulero, Roberto Fornelino, Marco Punta, Stefano Lise, Mar Varela, Luis P. del Carpio, Rafael Moreno, Marcel Costa-García, Dietmar Rieder, Zlatko Trajanoski, Alena Gros, Ramón Alemany, Josep María Piulats, and Rebeca Sanz-Pamplona

Subjects
GNA11, GNAQ, HLA, immunotherapy, neoantigen, uveal melanoma, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

ABSTRACTUveal melanoma (UM) is the most common ocular malignancy in adults. Nearly 95% of UM patients carry the mutually exclusive mutations in the homologous genes GNAQ (amino acid change Q209L/Q209P) and GNA11 (aminoacid change Q209L). UM is located in an immunosuppressed organ and does not suffer immunoediting. Therefore, we hypothesize that driver mutations in GNAQ/11 genes could be recognized by the immune system. Genomic and transcriptomic data from primary uveal tumors were collected from the TCGA-UM dataset (n = 80) and used to assess the immunogenic potential for GNAQ/GNA11 Q209L/Q209P mutations using a variety of tools and HLA type information. All prediction tools showed stronger GNAQ/11 Q209L binding to HLA than GNAQ/11 Q209P. The immunogenicity analysis revealed that Q209L is likely to be presented by more than 73% of individuals in 1000 G databases whereas Q209P is only predicted to be presented in 24% of individuals. GNAQ/11 Q209L showed a higher likelihood to be presented by HLA-I molecules than almost all driver mutations analyzed. Finally, samples carrying Q209L had a higher immune-reactive phenotype. Regarding cancer risk, seven HLA genotypes with low Q209L affinity show higher frequency in uveal melanoma patients than in the general population. However, no clear association was found between any HLA genotype and survival. Results suggest a high potential immunogenicity of the GNAQ/11 Q209L variant that could allow the generation of novel therapeutic tools to treat UM like neoantigen vaccinations.

Published
2023
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424. Bacillus subtilis NDmed, a model strain for biofilm genetic studies

Author

Yasmine Dergham, Dominique Le Coq, Arnaud Bridier, Pilar Sanchez-Vizuete, Hadi Jbara, Julien Deschamps, Kassem Hamze, Ken-ichi Yoshida, Marie-Françoise Noirot-Gros, and Romain Briandet

Subjects
Biofilms, Bacillus subilis, NDmed, CLSM, Pellicle, Colony, Biotechnology, TP248.13-248.65, Microbiology, QR1-502
Abstract

The Bacillus subtilis strain NDmed was isolated from an endoscope washer-disinfector in a medical environment. NDmed can form complex macrocolonies with highly wrinkled architectural structures on solid medium. In static liquid culture, it produces thick pellicles at the interface with air as well as remarkable highly protruding ‘‘beanstalk-like’’ submerged biofilm structures at the solid surface. Since these mucoid submerged structures are hyper-resistant to biocides, NDmed has the ability to protect pathogens embedded in mixed-species biofilms by sheltering them from the action of these agents. Additionally, this non-domesticated and highly biofilm forming strain has the propensity of being genetically manipulated. Due to all these properties, the NDmed strain becomes a valuable model for the study of B. subtilis biofilms. This review focuses on several studies performed with NDmed that have highlighted the sophisticated genetic dynamics at play during B. subtilis biofilm formation. Further studies in project using modern molecular tools of advanced technologies with this strain, will allow to deepen our knowledge on the emerging properties of multicellular bacterial life.

Published
2023
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425. Teleconsultations for mental health: Recommendations from a Delphi panel

Author

Valeria Manera, Claudia Partos, Olivier Beauchet, Michel Benoit, Benjamin Dupetit, Julia Elbaum, Roxane Fabre, Morgane Gindt, Auriane Gros, Rachid Guerchouche, Stefan Klöppel, Alexandra König, Annick Martin, Aurélie Mouton, Marie-Pierre Pancrazi, Antonios Politis, Gabriel Robert, Guillaume Sacco, Sabrina Sacconi, Kim Sawchuk, Fabio Solari, Lucille Thiebot, Pietro Davide Trimarchi, Radia Zeghari, and Philippe Robert

Subjects
Teleconsultations, Mental health, Telepsychiatry, SWOT analysis, Recommendations, Information technology, T58.5-58.64, Psychology, BF1-990
Abstract

Introduction: The use of teleconsultations for mental health has drastically increased since 2020 due to the Covid19 pandemic. In the present paper, we aimed to analyze the advantages and disadvantages of teleconsultations for mental health compared to face-to-face consultations, and to provide recommendations in this domain. Methods: The recommendations were gathered using a Delphi methodology. The expert panel (N = 21) included professionals from the health and ICT domains. They answered questions via two rounds of web surveys, and then discussed the results in a plenary meeting. Some of the questions were also shared with non-experts (N = 104). Results: Both the experts and the non-experts with teleconsultation experience reported a general satisfaction concerning teleconsultations. A SWOT analysis revealed several strengths and opportunities of teleconsultations for mental health, but also several weaknesses and threats. The experts provided a set of practical recommendations for the preparation and organization of teleconsultations for mental health. Discussion: Teleconsultations for mental health have the potential to allow access to care for patients in remote and isolated areas. Thus, their use will unlikely be discontinued after the end of the pandemic. In this context, we suggest that the collaboration among clinicians, researchers, and interface designers is crucial to improve usability and user experience for both clinicians and patients. The importance of teaching teleconsultation skills and informing the public on the features of teleconsultations (e.g., data privacy/security) is also highlighted.

Published
2023
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426. Migration of surface-associated microbial communities in spaceflight habitats

Author

Daniele Marra, Thodoris Karapantsios, Sergio Caserta, Eleonora Secchi, Malgorzata Holynska, Simon Labarthe, Bastien Polizzi, Sandra Ortega, Margaritis Kostoglou, Christophe Lasseur, Ioannis Karapanagiotis, Sigolene Lecuyer, Arnaud Bridier, Marie-Françoise Noirot-Gros, and Romain Briandet

Subjects
Biofilm, Space flight, Microgravity, Transcriptomic, Adaptation, Evolution, Biotechnology, TP248.13-248.65, Microbiology, QR1-502
Abstract

Astronauts are spending longer periods locked up in ships or stations for scientific and exploration spatial missions. The International Space Station (ISS) has been inhabited continuously for more than 20 years and the duration of space stays by crews could lengthen with the objectives of human presence on the moon and Mars. If the environment of these space habitats is designed for the comfort of astronauts, it is also conducive to other forms of life such as embarked microorganisms. The latter, most often associated with surfaces in the form of biofilm, have been implicated in significant degradation of the functionality of pieces of equipment in space habitats. The most recent research suggests that microgravity could increase the persistence, resistance and virulence of pathogenic microorganisms detected in these communities, endangering the health of astronauts and potentially jeopardizing long-duration manned missions. In this review, we describe the mechanisms and dynamics of installation and propagation of these microbial communities associated with surfaces (spatial migration), as well as long-term processes of adaptation and evolution in these extreme environments (phenotypic and genetic migration), with special reference to human health. We also discuss the means of control envisaged to allow a lasting cohabitation between these vibrant microscopic passengers and the astronauts.

Published
2023
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427. Global biogeography of chemosynthetic symbionts reveals both localized and globally distributed symbiont groups

Author

Osvatic, Jay T, Wilkins, Laetitia GE, Leibrecht, Lukas, Leray, Matthieu, Zauner, Sarah, Polzin, Julia, Camacho, Yolanda, Gros, Olivier, van Gils, Jan A, Eisen, Jonathan A, Petersen, Jillian M, and Yuen, Benedict

Subjects
Microbiology, Environmental Sciences, Biological Sciences, Ecology, Life Below Water, Animals, Autotrophic Processes, Biodiversity, Biological Evolution, Bivalvia, Gammaproteobacteria, Host Specificity, Phylogeny, Phylogeography, Symbiosis, symbiosis, biogeography, recombination
Abstract

In the ocean, most hosts acquire their symbionts from the environment. Due to the immense spatial scales involved, our understanding of the biogeography of hosts and symbionts in marine systems is patchy, although this knowledge is essential for understanding fundamental aspects of symbiosis such as host-symbiont specificity and evolution. Lucinidae is the most species-rich and widely distributed family of marine bivalves hosting autotrophic bacterial endosymbionts. Previous molecular surveys identified location-specific symbiont types that "promiscuously" form associations with multiple divergent cooccurring host species. This flexibility of host-microbe pairings is thought to underpin their global success, as it allows hosts to form associations with locally adapted symbionts. We used metagenomics to investigate the biodiversity, functional variability, and genetic exchange among the endosymbionts of 12 lucinid host species from across the globe. We report a cosmopolitan symbiont species, Candidatus Thiodiazotropha taylori, associated with multiple lucinid host species. Ca. T. taylori has achieved more success at dispersal and establishing symbioses with lucinids than any other symbiont described thus far. This discovery challenges our understanding of symbiont dispersal and location-specific colonization and suggests both symbiont and host flexibility underpin the ecological and evolutionary success of the lucinid symbiosis.

Published
2021

428. Novel technique for the study of pileup events in cryogenic bolometers

Author

Armatol, A, Armengaud, E, Armstrong, W, Augier, C, Avignone, FT, Azzolini, O, Barabash, A, Bari, G, Barresi, A, Baudin, D, Bellini, F, Benato, G, Beretta, M, Bergé, L, Biassoni, M, Billard, J, Boldrini, V, Branca, A, Brofferio, C, Bucci, C, Camilleri, J, Capelli, S, Cappelli, L, Cardani, L, Carniti, P, Casali, N, Cazes, A, Celi, E, Chang, C, Chapellier, M, Charrier, A, Chiesa, D, Clemenza, M, Colantoni, I, Collamati, F, Copello, S, Cremonesi, O, Creswick, RJ, Cruciani, A, D'Addabbo, A, D'Imperio, G, Dafinei, I, Danevich, FA, de Combarieu, M, De Jesus, M, de Marcillac, P, Dell'Oro, S, Di Domizio, S, Dompè, V, Drobizhev, A, Dumoulin, L, Fantini, G, Faverzani, M, Ferri, E, Ferri, F, Ferroni, F, Figueroa-Feliciano, E, Formaggio, J, Franceschi, A, Fu, C, Fu, S, Fujikawa, BK, Gascon, J, Giachero, A, Gironi, L, Giuliani, A, Gorla, P, Gotti, C, Gras, P, Gros, M, Gutierrez, TD, Han, K, Hansen, EV, Heeger, KM, Helis, DL, Huang, HZ, Huang, RG, Imbert, L, Johnston, J, Juillard, A, Karapetrov, G, Keppel, G, Khalife, H, Kobychev, VV, Kolomensky, Yu G, Konovalov, S, Liu, Y, Loaiza, P, Ma, L, Madhukuttan, M, Mancarella, F, Mariam, R, Marini, L, Marnieros, S, Martinez, M, Maruyama, RH, Mauri, B, Mayer, D, Mei, Y, and Milana, S

Subjects
Nuclear and Plasma Physics, Particle and High Energy Physics, Physical Sciences, Nuclear and plasma physics
Abstract

Precise characterization of detector time resolution is of crucial importance for next-generation cryogenic-bolometer experiments searching for neutrinoless double-beta decay, such as CUPID, in order to reject background due to pileup of two-neutrino double-beta decay events. In this paper, we describe a technique developed to study the pileup rejection capability of cryogenic bolometers. Our approach, which consists of producing controlled pileup events with a programmable wave-form generator, has the benefit that we can reliably and reproducibly control the time separation and relative energy of the individual components of the generated pileup events. The resulting data allow us to optimize and benchmark analysis strategies to discriminate between individual and pileup pulses. We describe a test of this technique performed with a small array of detectors at the Laboratori Nazionali del Gran Sasso, in Italy; we obtain a 90% rejection efficiency against pulser-generated pileup events with rise time of ∼15ms down to time separation between the individual events of about 2ms.

Published
2021

429. Precise measurement of $2\nu\beta\beta$ decay of $^{100}$Mo with the CUPID-Mo detection technology

Author

Armengaud, E., Augier, C., Barabash, A. S., Bellini, F., Benato, G., Benoît, A., Beretta, M., Bergé, L., Billard, J., Borovlev, Yu. A., Bourgeois, Ch., Briere, M., Brudanin, V., Camus, P., Cardani, L., Casali, N., Cazes, A., Chapellier, M., Charlieux, F., de Combarieu, M., Dafinei, I., Danevich, F. A., De Jesus, M., Dumoulin, L., Eitel, K., Elkhoury, E., Ferri, F., Fujikawa, B. K., Gascon, J., Gironi, L., Giuliani, A., Grigorieva, V. D., Gros, M., Guerard, E., Helis, D. L., Huang, H. Z., Huang, R., Johnston, J., Juillard, A., Khalife, H., Kleifges, M., Kobychev, V. V., Kolomensky, Yu. G., Konovalov, S. I., Leder, A., Kotila, J., Loaiza, P., Ma, L., Makarov, E. P., de Marcillac, P., Marini, L., Marnieros, S., Misiak, D., Navick, X-F., Nones, C., Novati, V., Olivieri, E., Ouellet, J. L., Pagnanini, L., Pari, P., Pattavina, L., Paul, B., Pavan, M., Peng, H., Pessina, G., Pirro, S., Poda, D. V., Polischuk, O. G., Previtali, E., Redon, Th., Rozov, S., Rusconi, C., Sanglard, V., Schäffner, K., Schmidt, B., Shen, Y., Shlegel, V. N., Siebenborn, B., Singh, V., Tomei, C., Tretyak, V. I., Umatov, V. I., Vagneron, L., Velázquez, M., Weber, M., Welliver, B., Winslow, L., Xue, M., Yakushev, E., and Zolotarova, A. S.

Subjects
Nuclear Experiment, Physics - Instrumentation and Detectors
Abstract

We report the measurement of the two-neutrino double-beta ($2\nu\beta\beta$) decay of $^{100}$Mo to the ground state of $^{100}$Ru using lithium molybdate (\crystal) scintillating bolometers. The detectors were developed for the CUPID-Mo program and operated at the EDELWEISS-III low background facility in the Modane underground laboratory. From a total exposure of $42.235$ kg$\times$d, the half-life of $^{100}$Mo is determined to be $T_{1/2}^{2\nu}=[7.12^{+0.18}_{-0.14}\,\mathrm{(stat.)}\pm0.10\,\mathrm{(syst.)}]\times10^{18}$ years. This is the most accurate determination of the $2\nu\beta\beta$ half-life of $^{100}$Mo to date. We also confirm, with the statistical significance of $>3\sigma$, that the single-state dominance model of the $2\nu\beta\beta$ decay of $^{100}$Mo is favored over the high-state dominance model., Comment: 11 pages, 6 figures, 4 tables

Published
2019
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430. Measurements of the ionization efficiency of protons in methane

Author

L. Balogh, C. Beaufort, A. Brossard, J.-F. Caron, M. Chapellier, J.-M. Coquillat, E. C. Corcoran, S. Crawford, A. Dastgheibi-Fard, Y. Deng, K. Dering, D. Durnford, C. Garrah, G. Gerbier, I. Giomataris, G. Giroux, P. Gorel, M. Gros, P. Gros, O. Guillaudin, E. W. Hoppe, I. Katsioulas, F. Kelly, P. Knights, S. Langrock, P. Lautridou, I. Manthos, R. D. Martin, J. Matthews, J.-P. Mols, J.-F. Muraz, T. Neep, K. Nikolopoulos, P. O’Brien, M.-C. Piro, D. Santos, G. Savvidis, I. Savvidis, F. A. Vazquez de Sola Fernandez, M. Vidal, R. Ward, M. Zampaolo, and NEWS-G Collaboration

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract The amount of energy released by a nuclear recoil ionizing the atoms of the active volume of detection appears “quenched” compared to an electron of the same kinetic energy. This different behavior in ionization between electrons and nuclei is described by the Ionization Quenching Factor (IQF) and it plays a crucial role in direct dark matter searches. For low kinetic energies (below $$50~\textrm{keV}$$ 50 keV ), IQF measurements deviate significantly from common models used for theoretical predictions and simulations. We report measurements of the IQF for proton, an appropriate target for searches of Dark Matter candidates with a mass of approximately $$1~\textrm{GeV}$$ 1 GeV , with kinetic energies in between $$2~\textrm{keV}$$ 2 keV and $$13~\textrm{keV}$$ 13 keV in $$100~\textrm{mbar}$$ 100 mbar of methane. We used the Comimac facility in order to produce the motion of nuclei and electrons of controlled kinetic energy in the active volume, and a NEWS-G SPC to measure the deposited energy. The Comimac electrons are used as a reference to calibrate the detector with 7 energy points. A detailed study of systematic effects led to the final results well fitted by $$\textrm{IQF}~(E_K)= E_K^\alpha ~/~(\beta + E_K^\alpha )$$ IQF ( E K ) = E K α / ( β + E K α ) with $$\alpha = 0.70\pm 0.08$$ α = 0.70 ± 0.08 and $$\beta = 1.32\pm 0.17$$ β = 1.32 ± 0.17 . In agreement with some previous works in other gas mixtures, we measured less ionization energy than predicted from SRIM simulations, the difference reaching $$33\%$$ 33 % at $$2~\textrm{keV}$$ 2 keV .

Published
2022
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434. Teleconsultations for mental health: Recommendations from a Delphi panel

Author

Manera, Valeria, Partos, Claudia, Beauchet, Olivier, Benoit, Michel, Dupetit, Benjamin, Elbaum, Julia, Fabre, Roxane, Gindt, Morgane, Gros, Auriane, Guerchouche, Rachid, Klöppel, Stefan, König, Alexandra, Martin, Annick, Mouton, Aurélie, Pancrazi, Marie-Pierre, Politis, Antonios, Robert, Gabriel, Sacco, Guillaume, Sacconi, Sabrina, Sawchuk, Kim, Solari, Fabio, Thiebot, Lucille, Trimarchi, Pietro Davide, Zeghari, Radia, and Robert, Philippe

Published
2023
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437. New Limit for Neutrinoless Double-Beta Decay of Mo100 from the CUPID-Mo Experiment

Author

Armengaud, E, Augier, C, Barabash, AS, Bellini, F, Benato, G, Benoît, A, Beretta, M, Bergé, L, Billard, J, Borovlev, Yu A, Bourgeois, Ch, Brudanin, VB, Camus, P, Cardani, L, Casali, N, Cazes, A, Chapellier, M, Charlieux, F, Chiesa, D, de Combarieu, M, Dafinei, I, Danevich, FA, De Jesus, M, Dixon, T, Dumoulin, L, Eitel, K, Ferri, F, Fujikawa, BK, Gascon, J, Gironi, L, Giuliani, A, Grigorieva, VD, Gros, M, Guerard, E, Helis, DL, Huang, HZ, Huang, R, Johnston, J, Juillard, A, Khalife, H, Kleifges, M, Kobychev, VV, Kolomensky, Yu G, Konovalov, SI, Leder, A, Loaiza, P, Ma, L, Makarov, EP, de Marcillac, P, Mariam, R, Marini, L, Marnieros, S, Misiak, D, Navick, X-F, Nones, C, Norman, EB, Novati, V, Olivieri, E, Ouellet, JL, Pagnanini, L, Pari, P, Pattavina, L, Paul, B, Pavan, M, Peng, H, Pessina, G, Pirro, S, Poda, DV, Polischuk, OG, Pozzi, S, Previtali, E, Redon, Th, Rojas, A, Rozov, S, Rusconi, C, Sanglard, V, Scarpaci, JA, Schäffner, K, Schmidt, B, Shen, Y, Shlegel, VN, Siebenborn, B, Singh, V, Tomei, C, Tretyak, VI, Umatov, VI, Vagneron, L, Velázquez, M, Welliver, B, Winslow, L, Xue, M, Yakushev, E, Zarytskyy, M, and Zolotarova, AS

Subjects
Nuclear and Plasma Physics, Particle and High Energy Physics, Physical Sciences, CUPID-Mo Collaboration, nucl-ex, Mathematical Sciences, Engineering, General Physics, Mathematical sciences, Physical sciences
Abstract

The CUPID-Mo experiment at the Laboratoire Souterrain de Modane (France) is a demonstrator for CUPID, the next-generation ton-scale bolometric 0νββ experiment. It consists of a 4.2 kg array of 20 enriched Li_{2}^{100}MoO_{4} scintillating bolometers to search for the lepton-number-violating process of 0νββ decay in ^{100}Mo. With more than one year of operation (^{100}Mo exposure of 1.17  kg×yr for physics data), no event in the region of interest and, hence, no evidence for 0νββ is observed. We report a new limit on the half-life of 0νββ decay in ^{100}Mo of T_{1/2}>1.5×10^{24}  yr at 90% C.I. The limit corresponds to an effective Majorana neutrino mass ⟨m_{ββ}⟩

Published
2021

438. New Limit for Neutrinoless Double-Beta Decay of ^{100}Mo from the CUPID-Mo Experiment.

Author

Armengaud, E, Augier, C, Barabash, AS, Bellini, F, Benato, G, Benoît, A, Beretta, M, Bergé, L, Billard, J, Borovlev, Yu A, Bourgeois, Ch, Brudanin, VB, Camus, P, Cardani, L, Casali, N, Cazes, A, Chapellier, M, Charlieux, F, Chiesa, D, de Combarieu, M, Dafinei, I, Danevich, FA, De Jesus, M, Dixon, T, Dumoulin, L, Eitel, K, Ferri, F, Fujikawa, BK, Gascon, J, Gironi, L, Giuliani, A, Grigorieva, VD, Gros, M, Guerard, E, Helis, DL, Huang, HZ, Huang, R, Johnston, J, Juillard, A, Khalife, H, Kleifges, M, Kobychev, VV, Kolomensky, Yu G, Konovalov, SI, Leder, A, Loaiza, P, Ma, L, Makarov, EP, de Marcillac, P, Mariam, R, Marini, L, Marnieros, S, Misiak, D, Navick, X-F, Nones, C, Norman, EB, Novati, V, Olivieri, E, Ouellet, JL, Pagnanini, L, Pari, P, Pattavina, L, Paul, B, Pavan, M, Peng, H, Pessina, G, Pirro, S, Poda, DV, Polischuk, OG, Pozzi, S, Previtali, E, Redon, Th, Rojas, A, Rozov, S, Rusconi, C, Sanglard, V, Scarpaci, JA, Schäffner, K, Schmidt, B, Shen, Y, Shlegel, VN, Siebenborn, B, Singh, V, Tomei, C, Tretyak, VI, Umatov, VI, Vagneron, L, Velázquez, M, Welliver, B, Winslow, L, Xue, M, Yakushev, E, Zarytskyy, M, Zolotarova, AS, and CUPID-Mo Collaboration

Subjects
CUPID-Mo Collaboration, nucl-ex, General Physics, Mathematical Sciences, Physical Sciences, Engineering
Abstract

The CUPID-Mo experiment at the Laboratoire Souterrain de Modane (France) is a demonstrator for CUPID, the next-generation ton-scale bolometric 0νββ experiment. It consists of a 4.2 kg array of 20 enriched Li_{2}^{100}MoO_{4} scintillating bolometers to search for the lepton-number-violating process of 0νββ decay in ^{100}Mo. With more than one year of operation (^{100}Mo exposure of 1.17  kg×yr for physics data), no event in the region of interest and, hence, no evidence for 0νββ is observed. We report a new limit on the half-life of 0νββ decay in ^{100}Mo of T_{1/2}>1.5×10^{24}  yr at 90% C.I. The limit corresponds to an effective Majorana neutrino mass ⟨m_{ββ}⟩

Published
2021

439. Pulse shape discrimination in CUPID-Mo using principal component analysis

Author

Huang, R, Armengaud, E, Augier, C, Barabash, AS, Bellini, F, Benato, G, Beno t, A, Beretta, M, Bergé, L, Billard, J, Borovlev, YA, Bourgeois, C, Brudanin, VB, Camus, P, Cardani, L, Casali, N, Cazes, A, Chapellier, M, Charlieux, F, De Combarieu, M, Dafinei, I, Danevich, FA, De Jesus, M, Dixon, T, Dumoulin, L, Eitel, K, Ferri, F, Fujikawa, BK, Gascon, J, Gironi, L, Giuliani, A, Grigorieva, VD, Gros, M, Guerard, E, Helis, DL, Huang, HZ, Johnston, J, Juillard, A, Khalife, H, Kleifges, M, Kobychev, VV, Kolomensky, YG, Konovalov, SI, Loaiza, P, Ma, L, Makarov, EP, De Marcillac, P, Mariam, R, Marini, L, Marnieros, S, Misiak, D, Navick, XF, Nones, C, Norman, EB, Olivieri, E, Ouellet, JL, Pagnanini, L, Pari, P, Pattavina, L, Paul, B, Pavan, M, Peng, H, Pessina, G, Pirro, S, Poda, DV, Polischuk, OG, Previtali, E, Redon, T, Rozov, S, Rusconi, C, Sanglard, V, Scarpaci, JA, Sch ffner, K, Schmidt, B, Shen, Y, Shlegel, VN, Siebenborn, B, Singh, V, Tomei, C, Tretyak, VI, Umatov, VI, Vagneron, L, Velázquez, M, Weber, M, Welliver, B, Winslow, L, Xue, M, Yakushev, E, Zarytskyy, MM, and Zolotarova, AS

Subjects
Analysis and statistical methods, Calorimeters, Data processing methods, Double-beta decay detectors, physics.data-an, nucl-ex, physics.ins-det, Nuclear & Particles Physics, Physical Sciences, Engineering
Abstract

CUPID-Mo is a cryogenic detector array designed to search for neutrinoless double-beta decay (0νββ) of 100Mo. It uses 20 scintillating 100Mo-enriched Li2MoO4 bolometers instrumented with Ge light detectors to perform active suppression of α backgrounds, drastically reducing the expected background in the 0νββ signal region. As a result, pileup events and small detector instabilities that mimic normal signals become non-negligible potential backgrounds. These types of events can in principle be eliminated based on their signal shapes, which are different from those of regular bolometric pulses. We show that a purely data-driven principal component analysis based approach is able to filter out these anomalous events, without the aid of detector response simulations.

Published
2021

441. Two years of volatile organic compound online in situ measurements at the Site Instrumental de Recherche par Télédétection Atmosphérique (Paris region, France) using proton-transfer-reaction mass spectrometry

Author

L. Simon, V. Gros, J.-E. Petit, F. Truong, R. Sarda-Estève, C. Kalalian, A. Baudic, C. Marchand, and O. Favez

Subjects
Environmental sciences, GE1-350, Geology, QE1-996.5
Abstract

Volatile organic compounds (VOCs) have direct influences on air quality and climate. They indeed play a key role in atmospheric chemistry as precursors of secondary pollutants, such as ozone (O3) and secondary organic aerosols (SOA). In this respect, long-term datasets of in situ atmospheric measurements are crucial for characterizing the variability of atmospheric chemical composition, its sources, and trends. The ongoing establishment of the Aerosols, Cloud, and Trace gases Research InfraStructure (ACTRIS) allows implementation of the collection and provision of such high-quality datasets. In this context, online and continuous measurements of O3, nitrogen oxides (NOx), and aerosols have been carried out since 2012 at the SIRTA (Site Instrumental de Recherche par Télédétection Atmosphérique) observatory, located in the Paris region, France. Within the last decade, VOC measurements were conducted offline at SIRTA, until the implementation of real-time monitoring which started in January 2020 using a proton-transfer-reaction quadrupole mass spectrometer (PTR-Q-MS). The dataset acquired during the first 2 years of online VOC measurements provides insights into their seasonal and diurnal variabilities. The additional long-term datasets obtained from co-located measurements (NOx, aerosol physical and chemical properties, meteorological parameters) are used to better characterize the atmospheric conditions and to further interpret the obtained results. Results also include insights into VOC main sources and the influence of meteorological conditions and air mass origin on their levels in the Paris region. Due to the COVID-19 pandemic, the year 2020 notably saw a quasi-total lockdown in France in spring and a lighter one in autumn. Therefore, the focus is placed on the impact of these lockdowns on the VOC variability and sources. A change in the behaviour of VOC markers for anthropogenic sources was observed during the first lockdown, reflecting a change in human activities. A comparison with gas chromatography data from the Paris city centre consolidates the regional representativity of the SIRTA station for benzene, while differences are observed for shorter-lived compounds with a notable impact of their local sources. This dataset could be further used as input for atmospheric models and can be found at https://doi.org/10.14768/f8c46735-e6c3-45e2-8f6f-26c6d67c4723 (Simon et al., 2022a).

Published
2023
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442. Faceting the post-disaster built heritage reconstruction process within the digital twin framework for Notre-Dame de Paris

Author

Antoine Gros, Anaïs Guillem, Livio De Luca, Élise Baillieul, Benoit Duvocelle, Olivier Malavergne, Lise Leroux, and Thierry Zimmer

Subjects
Medicine, Science
Abstract

Abstract April 15th, 2019: Notre-Dame Cathedral in Paris was burning, the spire collapsed on the nave, vaults crumbled and most of the timber roof was gone. In the post-disaster context, the authenticity and the monitoring of the archaeological remains are crucial for their potential reuse during reconstruction. This paper analyzes the collapsed transverse arch from the nave of Notre-Dame as a case study of reconstruction, using the digital twin framework. We propose four facets for the digital twin experiment—physical anastylosis, reverse engineering, spatio-temporal tracking of assets, and operational research—that are described in detail, while being assembled to support a hybrid reconstruction hypothesis. The digital twin can realize the parallel unfolding of physical-native and digital-native processes, while acquiring and storing heterogeneous information as semantically structured data. The results demonstrate that the proposed modeling method facilitates the formalization and validation of the reconstruction problem and increases solutions performances. As result, we present a digital twin framework application ranging from acquisition to data processing that informs a successful hybrid reconstruction hypothesis.

Published
2023
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446. Procedure qualification and integration of the continuous external Rogowski diagnostics to the superconducting magnets of ITER tokamak

Author

Ma, Y., Nakamoto, M., Sakurai, T., Kiyoshi, Y., Iguchi, M., Hong, Y., Bellesia, B., Aprili, P., Luongo, C., Koczorowski, S., Gomikawa, K., Tronza, V., Nishino, H., Peluso, B., Gros, G., Pelcot, F., Hattat, A., Huguenot, S., Bony, F., Lama, J., Fujiwara, E., Okada, Y., Yamane, M., Baratta, A., Battaglia, D., Marteil, H., Counsell, G., Vayakis, G., and Walsh, M.

Published
2023
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448. Neutralising antibody responses against SARS-CoV-2 Omicron BA.4/5 and wild-type virus in patients with inflammatory bowel disease following three doses of COVID-19 vaccine (VIP): a prospective, multicentre, cohort study

Author

Chukwurah, Ijeoma, Haq, Sulaimaan, Lo, Jonathan, Shah, Parita, Wilken-Smith, Stephanie, Ramanathan, Anitha, Patel, Mikin, Romanczuk, Lidia, King, Rebecca, Domingo, Jason, Shamtally, Djamila, Mendoza, Vivien, Sanchez, Joanne, Stark, Hannah, Knight, Bridget, Bee, Louise, Estember, Charmaine, Barnes, Anna, Watkins, Darcy, Stone, Sam, Kirkwood, John, Parkinson, Marian, Gardner-Thorpe, Helen, Covil, Kate, Derikx, Lauranne, Alcalde, Beatriz Gros, Lee, Irish, Cipriano, Bessie, Ruocco, Giuseppe, Baden, Manisha, Cooke, Graham, Kourampa, Evgenia, Pasquale, Ciro, Robisco-Diaz, Elena, Bhatti, Suhaylah, Liu, Zhigang, Alexander, James L., Le, Kaixing, Zhou, Xin, Ibraheim, Hajir, Anandabaskaran, Sulak, Saifuddin, Aamir, Lin, Kathy Weitung, McFarlane, Leon R., Constable, Laura, Seoane, Rocio Castro, Anand, Nikhil, Bewshea, Claire, Nice, Rachel, D'Mello, Andrea, Jones, Gareth R., Balarajah, Sharmili, Fiorentino, Francesca, Sebastian, Shaji, Irving, Peter M., Hicks, Lucy C., Williams, Horace RT., Kent, Alexandra J., Linger, Rachel, Parkes, Miles, Kok, Klaartje, Patel, Kamal V., Teare, Julian P., Altmann, Daniel M., Boyton, Rosemary J., Hart, Ailsa L., Lees, Charlie W., Goodhand, James R., Kennedy, Nicholas A., Pollock, Katrina M., Ahmad, Tariq, and Powell, Nick

Published
2023
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