3,074 results on '"Fernández, D."'
Search Results
402. Ultrasmall iron oxide nanoparticles cisplatin (IV) prodrug nanoconjugate: ICP-MS based strategies to evaluate the formation and drug delivery capabilities in single cells
- Author
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Turiel-Fernández, D., primary, Gutiérrez-Romero, L., additional, Corte-Rodriguez, M., additional, Bettmer, J., additional, and Montes-Bayón, M., additional
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- 2021
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403. BIOMECHANICS OF A NEW TECHNIQUE FOR FLEXOR TENDON TENORRAPHY OF THE HAND
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García Cabeza, S, primary, Lara Guerrero, M, additional, Salinas Ramila, F, additional, Martínez Magide, G J, additional, Carnero López, S, additional, Martín Muñiz, C, additional, Pérez Arias, A, additional, and Camporro Fernández, D, additional
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- 2021
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- View/download PDF
404. Understanding the impacts of contaminant and pathogen flow through marine food webs
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Pierce, Graham J., Gutiérrez-Muñoz, Paula, Petitguyot, Marie, Fariñas, Andrea, Read, Fiona L., Hernández-Milian, Gema, Hernández-González, Alberto, Méndez, P., López, Alfredo, Cedeira, J., Covelo, Pablo, Jacquot, S., Fernández, D., García Martínez, Elena, and Saavedra, Camilo
- Abstract
ICES Annual Science Conference 2021, 6–10 September, Virtual conference
- Published
- 2021
405. Are environmental pollution and biodiversity levels associated to the spread and mortality of COVID-19? A four-month global analysis
- Author
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Fernández D, Giné-Vázquez I, Liu I, Yucel R, Nai Ruscone M, Morena M, García VG, Haro JM, Pan W, and Tyrovolas S
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Air quality ,COVID-19 ,Transmission ,Global ,Biodiversity ,Mortality - Abstract
On March 12th, 2020, the WHO declared COVID-19 as a pandemic. The collective impact of environmental and ecosystem factors, as well as biodiversity, on the spread of COVID-19 and its mortality evolution remain empirically unknown, particularly in regions with a wide ecosystem range. The aim of our study is to assess how those factors impact on the COVID-19 spread and mortality by country. This study compiled a global database merging WHO daily case reports with other publicly available measures from January 21st to May 18th, 2020. We applied spatio-temporal models to identify the influence of biodiversity, temperature, and precipitation and fitted generalized linear mixed models to identify the effects of environmental variables. Additionally, we used count time series to characterize the association between COVID-19 spread and air quality factors. All analyses were adjusted by social demographic, country-income level, and government policy intervention confounders, among 160 countries, globally. Our results reveal a statistically meaningful association between COVID-19 infection and several factors of interest at country and city levels such as the national biodiversity index, air quality, and pollutants elements (PM(10,) PM(2.5)(,) and O(3)). Particularly, there is a significant relationship of loss of biodiversity, high level of air pollutants, and diminished air quality with COVID-19 infection spread and mortality. Our findings provide an empirical foundation for future studies on the relationship between air quality variables, a country's biodiversity, and COVID-19 transmission and mortality. The relationships measured in this study can be valuable when governments plan environmental and health policies, as alternative strategy to respond to new COVID-19 outbreaks and prevent future crises.
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- 2021
406. Estimating the COVID-19 Spread Through Real-time Population Mobility Patterns: Surveillance in Low- and Middle-Income Countries
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Tyrovolas S, Giné-Vázquez I, Fernández D, Morena M, Koyanagi A, Janko M, Haro JM, Lin Y, Lee P, Pan W, Panagiotakos D, and Molassiotis A
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transmission ,social distancing ,low and middle-income countries ,estimate ,pattern ,digital public health ,policy ,database ,surveillance ,real-time ,COVID-19 ,emerging countries ,mobile data - Abstract
BACKGROUND: On January 21, 2020, the World Health Organization reported the first case of severe acute respiratory syndrome coronavirus 2, which rapidly evolved to the COVID-19 pandemic. Since then, the virus has also rapidly spread among Latin American, Caribbean, and African countries. OBJECTIVE: The first aim of this study is to identify new emerging COVID-19 clusters over time and space (from January 21 to mid-May 2020) in Latin American, Caribbean, and African regions, using a prospective space-time scan measurement approach. The second aim is to assess the impact of real-time population mobility patterns between January 21 and May 18, 2020, under the implemented government interventions, measurements, and policy restrictions on COVID-19 spread among those regions and worldwide. METHODS: We created a global COVID-19 database, of 218 countries and territories, merging the World Health Organization daily case reports with other measures such as population density and country income levels for January 21 to May 18, 2020. A score of government policy interventions was created for low, intermediate, high, and very high interventions. The population's mobility patterns at the country level were obtained from Google community mobility reports. The prospective space-time scan statistic method was applied in five time periods between January and May 2020, and a regression mixed model analysis was used. RESULTS: We found that COVID-19 emerging clusters within these five periods of time increased from 7 emerging clusters to 28 by mid-May 2020. We also detected various increasing and decreasing relative risk estimates of COVID-19 spread among Latin American, Caribbean, and African countries within the period of analysis. Globally, population mobility to parks and similar leisure areas during at least a minimum of implemented intermediate-level control policies (when compared to low-level control policies) was related to accelerated COVID-19 spread. Results were almost consistent when regional stratified analysis was applied. In addition, worldwide population mobility due to working during high implemented control policies and very high implemented control policies, when compared to low-level control policies, was related to positive COVID-19 spread. CONCLUSIONS: The prospective space-time scan is an approach that low-income and middle-income countries could use to detect emerging clusters in a timely manner and implement specific control policies and interventions to slow down COVID-19 transmission. In addition, real-time population mobility obtained from crowdsourced digital data could be useful for current and future targeted public health and mitigation policies at a global and regional level.
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- 2021
407. Risk of all-cause mortality associated with chronic obstructive pulmonary disease and the role of healthy ageing trajectories: a population-based study of middle-aged and older adults
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Bayes-Marin I, Sánchez-Niubó A, Fernández D, Haro JM, and Olaya B
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public health ,parasitic diseases ,epidemiology ,chronic airways disease - Abstract
OBJECTIVES: The aims were to study the risk of all-cause mortality associated with chronic obstructive pulmonary disease (COPD) and healthy ageing trajectories (HAT) in three birth cohorts and to determine the moderating role of HAT in the association between COPD and all-cause mortality. DESIGN: Prospective cohort study. SETTING: Data from waves 1 to 5 of The Survey of Health, Ageing and Retirement in Europe. PARTICIPANTS: The total sample was 28 857 community-dwelling individuals aged 50+ years. MAIN OUTCOME: All-cause mortality associated with COPD and HAT adjusting for covariates. We performed Aalen additive hazards models to explore these associations. Interactions between COPD and HAT were also explored. Analyses were conducted separately in three birth cohorts (>1945, 1936-1945 and =1935). Latent class growth analysis was used to classify participants into HAT. RESULTS: Three parallel HAT were found in the three birth cohorts ('low', 'medium' and 'high' healthy ageing). Participants with COPD had an increased mortality risk, but this effect was no longer significant after adjusting for covariates. The 'low' HAT was associated with increased mortality risk in the three subsamples, although this effect was lower after adjustment. The interaction between COPD and HAT was significant only in the =1935 birth cohort, indicating that those with COPD and a 'low' trajectory had a greater risk of mortality. CONCLUSIONS: The healthy ageing scale may be a suitable tool to identify patients at higher risk to mitigate disease burden and improve patients' quality of life.
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- 2021
408. Social network size, loneliness, physical functioning and depressive symptoms among older adults: Examining reciprocal associations in four waves of the Longitudinal Aging Study Amsterdam (LASA)
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Joan Domènech Abella, Mundó J, Switsers L, van Tilburg T, Fernández D, and Aznar-Lou I
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depressive symptoms ,social isolation ,physical functioning ,older adults ,loneliness - Abstract
INTRODUCTION: Previous research indicates that social isolation, loneliness, physical dysfunction and depressive symptoms are interrelated factors, little is known about the potential pathways among them. The aim of the study is to analyse simultaneously reciprocal relationships that could exist between the four factors to clarify potential mediation effects. METHODS: Within a large representative sample of older people in the Longitudinal Aging Study Amsterdam (LASA), participants aged 75 and over were followed up over a period of 11 years (four waves). We tested cross-lagged and autoregressive longitudinal associations of social network size, loneliness, physical functioning and depressive symptoms using structural equation modelling (SEM). RESULTS: Several statistically significant cross-lagged associations were found: decreasing physical functioning (Coef. = -0.03; p
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- 2021
409. Impacts of organic pollutants on cetaceans in NW Spain
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Pierce, Graham J., Gutiérrez-Muñoz, Paula, Fariñas, Andrea, Fernández, D., Petitguyot, Marie, Read, Fiona L., Hernández, A., Saavedra, Camilo, Hernández-Milian, Gema, Viñas Diéguez, L., Pérez Fernández, B., Jaquot, S., Méndez, P., López, Alfredo, and Cedeira, J.
- Abstract
Poster.-- Pollution 2025: Intersessional Workshop, 21 October 2021
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- 2021
410. Thermal tolerance and vulnerability to climate changein subterranean species: a case study using an Iberianendemic pseudoscorpion
- Author
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Colado-Manero, R., García-Meseguer, A. J., Mirón-Galton, J. M., Botella-Cruz, M., Pallares-Párraga, S., and Sánchez-Fernández, D.
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Climate data ,Global Change ,Distributional data ,Physiological tolerance - Abstract
© 2021 The Authors. Insect Conservation and Diversity published by John Wiley & Sons Ltd on behalf of Royal Entomological Society. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, providedthe original work is properly cited,the use is non-commercial and no modifications or adaptations are made. To access the final edited and published work see DOI.: 10.1111/icad.12541 1. Scientists are renewing their efforts to predict the impact of climate change on biodiversity. Subterranean environments represent ideal systems to study the effect of global change in species with poor dispersal capabilities. 2. We assess the vulnerability to climate change of the subterranean pseudoscorpion Neobisium (Blothrus) vasconicum vasconicum (Nonídez, 1925) (Neobisiidae). 3. Thermal tolerance was measured using two complementary estimates of upper thermal limits: (i) from thermal conditions of the localities in which the species occurs (realised upper thermal limit, RUTL), and (ii) from experimentally determined thermal tolerance data (physiological upper thermal limit, PhUTL). Then, thermal safety margins (TSM) were calculated for all known localities for current and future climatic conditions, using the thermal limits from both approaches. 4. The physiological thermal limit (PhUTL = 17.57 C) was 3.27 C higher than that obtained from the distributional and climate data (i.e., the hottest cave in which the species occurs; RUTL = 14.3 C). Regarding TSM, the future temperature (2070; RCP 8.5) of a half of the caves will be higher than the RUTL and in none of them, it would exceed the average PhUTL. This indicates that the species could have some physiological capacity to cope with warming temperatures in situ. 5. We hypothesize that the most realistic upper thermal limit of the species could be between the RUTL and PhUTL. This study shows that complementary approaches to estimate thermal tolerance could provide more accurate predictions of the capacity to face climate change, not only in subterranean species, but also in poor dispersal species.
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- 2021
411. Changes in the quality of pressed cheese produced with raw milk in response to different n-3 fatty acid supplements in the diet of dairy sheep
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Delgado, D., Fernández, D., Gallardo, B., Lavín, Paz, Mantecón, Ángel R., Manso, Teresa, Agencia Estatal de Investigación (España), European Commission, and Junta de Castilla y León
- Abstract
Trabajo presentado al: IDF International Cheese Science and Technology Symposium. 7-11 junio. Virtual meeting., This research was funded by the Spanish State Research Agency (AEI) and the European Regional Development Fund (Project AGL2016-75159-C2-1-R) and FEADER through the ITACyL COAGUSEN project (PEP 2017/000809).
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- 2021
412. Heterogeneity in the Effectiveness of Non-pharmaceutical Interventions During the First SARS-CoV2 Wave in the United States
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Pan WK, Fernández D, Tyrovolas S, Iago GV, Dasgupta RR, Zaitchik BF, Lantos PM, and Woods CW
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United States ,mortality rate ,SARS-CoV-2 ,non-pharmaceutical intervention (NPI) ,doubling time - Abstract
Background: Attempts to quantify effect sizes of non-pharmaceutical interventions (NPI) to control COVID-19 in the US have not accounted for heterogeneity in social or environmental factors that may influence NPI effectiveness. This study quantifies national and sub-national effect sizes of NPIs during the early months of the pandemic in the US. Methods: Daily county-level COVID-19 cases and deaths during the first wave (January 2020 through phased removal of interventions) were obtained. County-level cases, doubling times, and death rates were compared to four increasingly restrictive NPI levels. Socio-demographic, climate and mobility factors were analyzed to explain and evaluate NPI heterogeneity, with mobility used to approximate NPI compliance. Analyses were conducted separately for the US and for each Census regions (Pacific, Mountain, east/West North Central, East/West South Central, South Atlantic, Middle Atlantic and New England). A stepped-wedge cluster-randomized trial analysis was used, leveraging the phased implementation of policies. Results: Aggressive (level 4) NPIs were associated with slower COVID-19 propagation, particularly in high compliance counties. Longer duration of level 4 NPIs was associated with lower case rates (log beta -0.028, 95% CI -0.04 to -0.02) and longer doubling times (log beta 0.02, 95% CI 0.01-0.03). Effects varied by Census region, for example, level 4 effects on doubling time in Pacific states were opposite to those in Middle Atlantic and New England states. NPI heterogeneity can be explained by differential timing of policy initiation and by variable socio-demographic county characteristics that predict compliance, particularly poverty and racial/ethnic population. Climate exhibits relatively consistent relationships across Census regions, for example, higher minimum temperature and specific humidity were associated with lower doubling times and higher death rates for this period of analysis in South Central, South Atlantic, Middle Atlantic, and New England states. Conclusion and Relevance: Heterogeneity exists in both the effectiveness of NPIs across US Census regions and policy compliance. This county-level variability indicates that control strategies are best designed at community-levels where policies can be tuned based on knowledge of local disparities and compliance with public health ordinances.
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- 2021
413. Microplastics dynamics during spring and neap tidal conditions in a highly regulated estuary: Guadalquivir River (SW Spain).
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González-Fernández, D., Manzano-Medina, Sandra, González-Duarte, Manuel María, Cózar, A., González-Fernández, D., Manzano-Medina, Sandra, González-Duarte, Manuel María, and Cózar, A.
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- 2021
414. Floating macrolitter leaked from Europe into the ocean
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González-Fernández, D., Cózar, A., Hanke, G., Viejo, J., Morales-Caselles, C., Bakiu, R., Barceló, D., Bessa, F., Bruge, A., Cabrera, M., Castro-Jiménez, C., Constant, M., Crosti, R., Galletti, Y., Kideys, A.E., Machitadze, N., de Brito, J.P., Pogojeva, M., Ratola, N., Rigueira, J., Rojo-Nieto, Elisa, Savenko, O., Schöneich-Argent, R.I., Siedlewicz, G., Suaria, G., Tourgeli, M., González-Fernández, D., Cózar, A., Hanke, G., Viejo, J., Morales-Caselles, C., Bakiu, R., Barceló, D., Bessa, F., Bruge, A., Cabrera, M., Castro-Jiménez, C., Constant, M., Crosti, R., Galletti, Y., Kideys, A.E., Machitadze, N., de Brito, J.P., Pogojeva, M., Ratola, N., Rigueira, J., Rojo-Nieto, Elisa, Savenko, O., Schöneich-Argent, R.I., Siedlewicz, G., Suaria, G., and Tourgeli, M.
- Abstract
Riverine systems act as converging pathways for discarded litter within drainage basins, becoming key elements in gauging the transfer of mismanaged waste into the ocean. However, riverine litter data are scarce and biased towards microplastics, generally lacking information about larger items. Based on the first ever database of riverine floating macrolitter across Europe, we have estimated that between 307 and 925 million litter items are released annually from Europe into the ocean. The plastic fraction represented 82% of the observed litter, mainly fragments and single-use items (that is, bottles, packaging and bags). Our modelled estimates show that a major portion of the total litter loading is routed through small-sized drainage basins (<100 km2), indicating the relevance of small rivers, streams and coastal run-off. Moreover, the major contribution of high-income countries to the macrolitter inputs suggests that reducing ocean pollution cannot be achieved only by improving waste management, but also requires changing consumption habits and behaviour to curb waste generation at source. The inability of countries with well-developed recovery systems to control the leakage of waste into the environment further supports the need to regulate the production and use of plastic on a global scale.
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- 2021
415. Changes in the quality of pressed cheese produced with raw milk in response to different n-3 fatty acid supplements in the diet of dairy sheep
- Author
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Agencia Estatal de Investigación (España), European Commission, Junta de Castilla y León, Delgado, D., Fernández, D., Gallardo, B., Lavín, Paz, Mantecón, Ángel R., Manso, Teresa, Agencia Estatal de Investigación (España), European Commission, Junta de Castilla y León, Delgado, D., Fernández, D., Gallardo, B., Lavín, Paz, Mantecón, Ángel R., and Manso, Teresa
- Published
- 2021
416. Especies Exóticas Invasoras de sistemas acuáticos epicontinentales de la Península Ibérica: priorización y listas de referencia elaboradas por LIFE INVASAQUA
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European Commission, Oliva-Paterna, Francisco J., Ribeiro, F., Guillén, A., García-Murillo, P., Anastacio, P.A., Cobo, F., Gallardo, A., Hermoso, V., García-Berthou, Emili, Aguiar, F., Almeida, D., Arias, A., Ayres, C., Banha, F., Biurrum, I., Boix, D., Cabezas, M.P., Calero, S., Capdevila, L., Capinha, C, Campos, J.A, Carapato, A., Casals, F., Cirujano, Santos, Clavero, Miguel, Cuesta, J. A., Encarnazao, J.P., Fernández-Delgado, C., Franco, Javier, García-Meseguer, A.J., Guareschi, S., Guerrero, A., Laguna, E., Machordom, Annie, Martelo, J., Mellado, A., Miranda, R., Morcillo Alonso, Felipe, Moreno, Juan Camilo, Oficialdegui, Francisco J., Olivo del Amo, R., Oscoz, J., Otero, J.C., Rodríguez-Merino, A., Ros, M., Perdices, Anabel, Pou, Q., Sánchez, E., Sanchez, M.I., Sánchez-Fernández, D., Sánchez-González, J. R., Soriano, Oscar, Teodósio, M. A., Torralva, Mar, Vieira, R., Zamora, A., Zamora, J.M., European Commission, Oliva-Paterna, Francisco J., Ribeiro, F., Guillén, A., García-Murillo, P., Anastacio, P.A., Cobo, F., Gallardo, A., Hermoso, V., García-Berthou, Emili, Aguiar, F., Almeida, D., Arias, A., Ayres, C., Banha, F., Biurrum, I., Boix, D., Cabezas, M.P., Calero, S., Capdevila, L., Capinha, C, Campos, J.A, Carapato, A., Casals, F., Cirujano, Santos, Clavero, Miguel, Cuesta, J. A., Encarnazao, J.P., Fernández-Delgado, C., Franco, Javier, García-Meseguer, A.J., Guareschi, S., Guerrero, A., Laguna, E., Machordom, Annie, Martelo, J., Mellado, A., Miranda, R., Morcillo Alonso, Felipe, Moreno, Juan Camilo, Oficialdegui, Francisco J., Olivo del Amo, R., Oscoz, J., Otero, J.C., Rodríguez-Merino, A., Ros, M., Perdices, Anabel, Pou, Q., Sánchez, E., Sanchez, M.I., Sánchez-Fernández, D., Sánchez-González, J. R., Soriano, Oscar, Teodósio, M. A., Torralva, Mar, Vieira, R., Zamora, A., and Zamora, J.M.
- Abstract
Foro sobre especies invasoras en las aguas continentales ibéricas, estado actual de conocimiento y prioridades de gestión. Las especies exóticas invasoras no sólo son uno de los principales impulsores de la pérdida de biodiversidad a nivel global, sino que también causan graves impactos en la economía y en la salud humana. Existe una falta de sensibilización de las sociedad española y portuguesa sobre la amenaza y problemática que supone las especies invasoras, lo que dificulta la movilización de sectores relevantes y otras partes interesadas para su gestión y control.
- Published
- 2021
417. Radiological risk assessment of naturally occurring radioactive materials in marine sediments and its application in industrialized coastal areas: Bay of Algeciras, Spain
- Author
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González-Fernández, D., Garrido-Pérez, M. C., Casas-Ruiz, M., Barbero, L., and Nebot-Sanz, E.
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- 2012
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418. Monthly electric energy demand forecasting with neural networks and Fourier series
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González-Romera, E., Jaramillo-Morán, M.A., and Carmona-Fernández, D.
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- 2008
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419. Origin of the Moving Groups and Their Contribution to the Determination of the Large-scale Galactic Potential
- Author
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Antoja, T., Fernández, D., Figueras, F., Moreno, E., Pichardo, B., Torra, J., Valenzuela, O., Diego, Jose M., editor, Goicoechea, Luis J., editor, González-Serrano, J. Ignacio, editor, and Gorgas, Javier, editor
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- 2010
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420. Recommendations for respiratory support in the newborn (III). Surfactant and nitric oxide
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Castillo Salinas, F., Elorza Fernández, D., Gutiérrez Laso, A., Moreno Hernando, J., Bustos Lozano, G., Gresa Muñoz, M., López de Heredia Goya, J., Aguar Carrascosa, M., Miracle Echegoyen, X., Fernández Lorenzo, J.R., Serrano, M.M., Concheiro Guisan, A., Carrasco Carrasco, C., Comuñas Gómez, J.J., Moral Pumarega, M.T., Sánchez Torres, A.M., and Franco, M.L.
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- 2015
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421. Recomendaciones para la asistencia respiratoria en el recién nacido (iii). Surfactante y óxido nítrico
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Castillo Salinas, F., Elorza Fernández, D., Gutiérrez Laso, A., Moreno Hernando, J., Bustos Lozano, G., Gresa Muñoz, M., López de Heredia Goya, J., Aguar Carrascosa, M., Miracle Echegoyen, X., Fernández Lorenzo, J.R., Serrano, M.M., Concheiro Guisan, A., Carrasco Carrasco, C., Comuñas Gómez, J.J., Moral Pumarega, M.T., Sánchez Torres, A.M., and Franco, M.L.
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- 2015
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422. Fecal Pollution in Coastal Marine Sediments from a Semi-Enclosed Deep Embayment Subjected to Anthropogenic Activities: An Issue to Be Considered in Environmental Quality Management Frameworks Development
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González-Fernández, D., Garrido-Pérez, M. C., Nebot-Sanz, E., and Sales-Márquez, D.
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- 2010
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423. Supersymmetric partners for the associated Lamé potentials
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Fernández, D. J. and Ganguly, A.
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- 2010
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424. Dermoscopy in general dermatology: practical tips for the clinician*
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Lallas, A., Giacomel, J., Argenziano, G., García-García, B., González-Fernández, D., Zalaudek, I., and Vázquez-López, F.
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- 2014
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425. Subacute central pontine myelinolysis secondary to hyperglycaemia
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Corps Fernández, D., Terrero Carpio, R., Escolar Escamilla, E., and Pinel González, A.
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- 2020
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426. Mielinólisis central pontina de curso subagudo secundario a hiperglucemias
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Corps Fernández, D., Terrero Carpio, R., Escolar Escamilla, E., and Pinel González, A.
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- 2020
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427. Fishes of southern South America: a story driven by temperature
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Cussac, V. E., Fernández, D. A., Gómez, S. E., and López, H. L.
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- 2009
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428. Energy density of sub-Antarctic fishes from the Beagle Channel
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Fernández, D. A., Lattuca, M. E., Boy, C. C., Pérez, A. F., Ceballos, S. G., Vanella, F. A., Morriconi, E. R., Malanga, G. F., Aureliano, D. R., Rimbau, S., and Calvo, J.
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- 2009
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429. Energy allocation in relation to spawning and overwintering of a diadromous Puyen (Galaxias maculatus) population in the southernmost limit of the species distribution
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Boy, C. C., Pérez, A. F., Fernández, D. A., Calvo, J., and Morriconi, E. R.
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- 2009
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430. Programas de fuerza en la arquitectura muscular del cuádriceps femoral: revisión sistemática
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Caamaño-Pérez, A., Taboada-Iglesias, Y., and Alonso-Fernández, D.
- Abstract
La arquitectura muscular es la disposición de los elementos contráctiles del músculo definidos como longitud del fascículo (LF), ángulo de peneación (AP), grosor muscular (GM) y área de sección transversal (ASTA). Estas se ven alteradas por las lesiones siendo en el cuádriceps uno de los grupos musculares con mayor incidencia. Por tanto, la exploración de las variables que influyen en dicha circunstancia constituye una labor relevante. El objetivo fue el de evaluar cómo afectan los entrenamientos de fuerza y de fuerza resistencia en la arquitectura muscular del cuádriceps femoral.
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- 2022
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431. Lifestyle behaviours in patients with established cardiovascular diseases: A European observational study
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Fernández, D., Brotons, C., Moral, I., Bulc, M., Afonso, M., Akan, H., Da Silva Martins, C.M., Fernández, D., Brotons, C., Moral, I., Bulc, M., Afonso, M., Akan, H., Da Silva Martins, C.M., and Yeditepe Üniversitesi
- Subjects
Cardiovascular diseases ,Prevention ,education ,General practitioners/family physicians - Abstract
Background: Patients who have experienced a cardiovascular clinical event such as a myocardial infarction or stroke qualify for intensive risk factor evaluation and management. The aim of this study is to explore lifestyle changes as well as the achievement of targets for risk factors in patients with established cardiovascular disease. Methods: Cross-sectional study conducted in primary care practices. The study was carried out in six European countries (Croatia, France, Portugal, Slovenia, Spain and Turkey). Patients with established cardiovascular disease (coronary heart disease and stroke) attended in primary care were selected and assessed from January to June 2016. Patients were recruited and assessed at the practice by research assistants between 6 months and 3 years after the event. Statistical comparisons were done with the unpaired two-sided Student's t-test for continuous variables and Chi-square test for categorical variables. Results: Nine hundred and seventy-three patients (32.4% females) were assessed. About 14% of them were smokers, 32% were physically inactive, and 30% had nutritionally poor eating behaviours. LDL cholesterol target value below 70 mg/dl was achieved in about 23% of patients, and in general, women were less cardio-protected by drugs than men. Conclusions: Many patients with established cardiovascular disease who attended in general practice still fail to achieve the lifestyle, risk factor, and therapeutic targets set by European guidelines. These results are relevant to general practitioners because these patients have a high risk of subsequent cardiovascular events, including MI, stroke, and death. © 2019 The Author(s). Slovenia Institute of Infection and Immunity Sveucilište u Zagrebu: Croatia National coordinators obtained approval from local research ethics committees in each country to conduct the survey. The approval of the ethics committee of the coordinating centre was done on June 10th 2015, with the reference number 4R15/117 (IDIAP Jordi Gol). The approval of the ethics committee of other centres were done by the Commitee for Medical Ethics of Heath Ministry of Slovenia (Slovenia), the Ethics Committee of the Yeditepe University, Faculty of Medicine (Turkey), Comité de Protection des Personnes (CPP) Sud-Ouest et Outre Mer III and Comité Consultatif sur le Traitement de l'Information en matière de Recherche dans le domaine de la Santé (CCTIRS), (France), the Ethics Commitee of Medical faculty University of Zagreb (Croatia) and the Health Ethics Committee of the Regional Health Administration of Northern Portugal (Portugal).
- Published
- 2019
432. Neoplasia neuroendocrina metastásica de origen desconocido: de la incertidumbre en el diagnóstico por imagen a la precisión de la cirugía radioguiada laparoscópica
- Author
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Sanz Viedma, S., primary, Alors Ruiz, J., additional, Roldán de la Rua, J., additional, Ortega Lozano, S., additional, Osorio Fernández, D., additional, and Suárez Muñoz, M.A., additional
- Published
- 2021
- Full Text
- View/download PDF
433. Titanium alloy microstructure fingerprint plots from in-process machining
- Author
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Suárez Fernández, D., primary, Wynne, B.P., additional, Crawforth, P., additional, and Jackson, M., additional
- Published
- 2021
- Full Text
- View/download PDF
434. Effect of forage type, season, and ripening time on selected quality properties of sheep milk cheese
- Author
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Renes, E., primary, Fernández, D., additional, Abarquero, D., additional, Ladero, V., additional, Álvarez, M.A., additional, Tornadijo, M.E., additional, and Fresno, J.M., additional
- Published
- 2021
- Full Text
- View/download PDF
435. Design and sensitivity of the Radio Neutrino Observatory in Greenland (RNO-G)
- Author
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Aguilar, J.A., primary, Allison, P., additional, Beatty, J.J., additional, Bernhoff, H., additional, Besson, D., additional, Bingefors, N., additional, Botner, O., additional, Buitink, S., additional, Carter, K., additional, Clark, B.A., additional, Connolly, A., additional, Dasgupta, P., additional, de Kockere, S., additional, de Vries, K.D., additional, Deaconu, C., additional, DuVernois, M.A., additional, Feigl, N., additional, García-Fernández, D., additional, Glaser, C., additional, Hallgren, A., additional, Hallmann, S., additional, Hanson, J.C., additional, Hendricks, B., additional, Hokanson-Fasig, B., additional, Hornhuber, C., additional, Hughes, K., additional, Karle, A., additional, Kelley, J.L., additional, Klein, S.R., additional, Krebs, R., additional, Lahmann, R., additional, Magnuson, M., additional, Meures, T., additional, Meyers, Z.S., additional, Nelles, A., additional, Novikov, A., additional, Oberla, E., additional, Oeyen, B., additional, Pandya, H., additional, Plaisier, I., additional, Pyras, L., additional, Ryckbosch, D., additional, Scholten, O., additional, Seckel, D., additional, Smith, D., additional, Southall, D., additional, Torres, J., additional, Toscano, S., additional, Van Den Broeck, D.J., additional, van Eijndhoven, N., additional, Vieregg, A.G., additional, Welling, C., additional, Wissel, S., additional, Young, R., additional, and Zink, A., additional
- Published
- 2021
- Full Text
- View/download PDF
436. Mitigation of CO2 emissions by hydrotalcites of Mg3Al-CO3 at 0 °C and high pressure
- Author
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Suescum-Morales, D., primary, Cantador-Fernández, D., additional, Jiménez, J.R., additional, and Fernández, J.M., additional
- Published
- 2021
- Full Text
- View/download PDF
437. CF4J 2.0: Adapting Collaborative Filtering for Java to new challenges of collaborative filtering based recommender systems
- Author
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Ortega, F., primary, Mayor, J., additional, López-Fernández, D., additional, and Lara-Cabrera, R., additional
- Published
- 2021
- Full Text
- View/download PDF
438. Revising the Effects of Local and Remote Atmospheric Forcing on the Atlantic Jet and Western Alboran Gyre Dynamics
- Author
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Bolado‐Penagos, M., primary, Sala, I., additional, Gomiz‐Pascual, J. J., additional, Romero‐Cózar, J., additional, González‐Fernández, D., additional, Reyes‐Pérez, J., additional, Vázquez, A., additional, and Bruno, M., additional
- Published
- 2021
- Full Text
- View/download PDF
439. Metabotropic Modulation of Potassium Channels During Synaptic Plasticity
- Author
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Fernández-Fernández, D., primary and Lamas, J.A., additional
- Published
- 2021
- Full Text
- View/download PDF
440. 3D Visual Odometry for Road Vehicles
- Author
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García-García, R., Sotelo, M. A., Parra, I., Fernández, D., Naranjo, J. E., and Gavilán, M.
- Published
- 2008
- Full Text
- View/download PDF
441. The epidemiology of life-threatening complications associated with reproductive process in public hospitals in Argentina
- Author
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Karolinski, A, Mercer, R, Micone, P, Ocampo, C, Mazzoni, A, Fontana, O, Messina, A, Winograd, R, Frers, M C, Nassif, J C, Elordi, H C, Lapidus, A, Taddeo, C, Damiano, M, Lambruschini, R, Muzzio, C, Pecker, B, Natale, S, Nowacki, D, Betular, Á, Breccia, G, Di Biase, L, Montes Varela, D, Dunaiewsky, A, Minsk, E, Fernández, D, Martire, L, Huespe, M, Laterra, C, Spagnuolo, R, and Gregoris, C
- Published
- 2013
- Full Text
- View/download PDF
442. Poster abstracts
- Author
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Ferrie, J., Shipley, M., Cappuccio, F., Brunner, E., Miller, M., Kumari, M., Marmot, M., Coenen, A., Castillo, J. L., Araya, F., Bustamante, G., Montecino, L., Torres, C., Oporto, S., Gronli, J., Fiske, E., Murison, R., Bjorvatn, B., Sorensen, E., Ursin, R., Portas, C. M., Rajaraman, S., Gribok, A., Wesensten, N., Balkin, T., Reifman, J., Dursunoglu, N., Ozkurt, S., Baser, S., Delen, O., Sarikaya, S., Sadler, P., Mitchell, P., Françon, D., Decobert, M., Herve, B., Richard, A., Griebel, G., Avenet, P., Scatton, B., Fur, G. L., Eckert, D., Jordan, A., Wellman, A., Smith, S., Malhotra, A., White, D., Bruck, D., Thomas, I., Kritikos, A., Oertel, W., Stiasny-Kolster, K., Garcia-Borreguero, D., Poewe, W., Hoegl, B., Kohnen, R., Schollmayer, E., Keffel, J., Trenkwalder, C., Valle, A., Roizenblatt, S., Fregni, F., Boggio, P., Tufik, S., Ward, K., Robertson, L., Palmer, L., Eastwood, P., Hillman, D., Lee, J., Mukherjee, S., de Padova, V., Barbato, G., Ficca, G., Zilli, I., Salzarulo, P., Veldi, M., Hion, T., Vasar, V., Kull, M., Nowak, L., Davis, J., Latzer, Y., Tzischinsky, O., Crowley, S., Carskadon, M., Anca-Herschkovitsch, M., Frey, D., Ortega, J., Wiseman, C., Farley, C., Wright, K., Campbell, A., Neill, A., Spiegel, K., Leproult, R., Tasali, E., Scherberg, N., van Cauter, E., Noradina, A. T., Karim, N. A., Norlinah, I., Raymond, A. A., Sahathevan, R., Hamidon, B., Werth, E., Poryazova, R., Khatami, R., Bassetti, C., Beran, R. G., Ainley, L., Holand, G., Duncan, J., Kinney, H., Davis, B., Hood, B., Frey, S., Schmidt, C., Hofstetter, M., Peigneux, P., Cajochen, C., Hu, W.-P., Li, J.-D., Zhang, C., Boehmer, L., Siegel, J., Zhou, Q.-Y., Sagawa, Y., Kondo, H., Takemura, T., Kanayama, H., Kaneko, Y., Sato, M., Kanbayashi, T., Hishikawa, Y., Shimizu, T., Viola, A., James, L., Schlangen, L., Dijk, D.-J., Andretic, R., Kim, Y.-C., Han, K.-A., Jones, F., Greenspan, R., Sanford, L., Yang, L., Tang, X., Dieter, K., Uta, E., Sven, H., Richard, M., Oyane, N., Pallesen, S., Holsten, F., Inoue, Y., Fujita, M., Emura, N., Kuroda, K., Uchimura, N., Johnston, A., Astbury, J., Kennedy, G., Hoedlmoser, K., Schabus, M., Pecherstorfer, T., Moser, S., Gruber, G., Anderer, P., Klimesch, W., Naidoo, N., Ferber, M., Pack, A., Neu, D., Mairesse, O., Hoffmann, G., Dris, A., Lambrecht, L., Linkowski, P., Verbanck, P., Le Bon, O., Matsuura, N., Yamao, M., Adachi, N., Aritomi, R., Komada, Y., Tanaka, H., Shirakawa, S., Kondoh, H., Takemura, F., Ohnuma, S., Suzuki, M., Uemura, S., Iskra-Golec, I., Smith, L., Thanh, D.-V., Boly, M., Phillips, C., Steven, L., Luxen, A., Maquet, M., Jay, S., Dawson, D., Lamond, N., Basner, M., Fomberstein, K., Dinges, D., Ogawa, K., Nittono, H., Yamazaki, K., Hori, T., Glamann, C., Hornung, O., Hansen, M.-L, Danker-Hopfe, H., Jung, C., Kecklund, G., Anund, A., Peters, B., Åkerstedt, T., Verster, J., Roehrs, T., Mets, M., de Senerpont Domis, L., Olivier, B., Volkerts, E., Knutson, K., Lauderdale, D., Rathouz, P., Christie, M., Chen, L., Bolortuya, Y., Lee, E., Mckenna, J., Mccarley, R., Strecker, R., Tamaki, M., Matsuoka, T., Aritake, S., Suzuki, H., Kuriyama, K., Ozaki, A., Abe, Y., Enomoto, M., Tagaya, H., Mishima, K., Matsuura, M., Uchiyama, M., Lima-Pacheco, E., Davis, K., Sabourin, C., Lortie-Lussier, M., de Koninck, J., van Der Werf, Y., van Der Helm, E., Schoonheim, M., van Someren, E., Tokley, M., Ball, M., Sato, T., Ghilardi, M. F., Moisello, C., Bove, M., Busi, M., Pelosin, E., Tononi, G., Eguchi, N., Sakata, M., Urade, Y., Doe, N., Yoshihara, K., Abe, K., Manabe, Y., Iwatsuki, K., Hayashi, T., Shoji, M., Kamiya, T., Gooley, J., Brainard, G., Rajaratnam, S., Kronauer, R., Czeisler, C., Lockley, S., Phillips, A., Robinson, P., Burgess, H., Revell, V., Eastman, C., Bihari, S., Ramakrishnan, N., Camerino, D., Conway, P. M., Costa, G., Vandewalle, G., Albouy, G., Sterpenich, V., Darsaud, A., Rauchs, G., Berken, P.-Y, Balteau, E., Maquet, P., Tendero, J. A., Domenech, M. P., Isern, F. S., Martínez, C., Roure, N., Sancho, E. E., Moreno, C. R., Silva, M., Marqueze, E. C., Waage, S., Bobko, N., Chernyuk, V., Yavorskiy, Y., Saxvig, I., Sørensen, E., de Mello, M. T., Esteves, A., Teixeira, C., Bittencourt, L. R., Silva, R., Pires, M. L., Mottram, V., Middelton, B., Arendt, J., Amaral, O., Rodrigues, M., Pereira, C., Tavares, I., Baba, K., Honma, S., Honma, K.-I., Yamanaka, Y., Hashimoto, S., Tanahashi, Y., Nishide, S.-Y, Honma, K.-I, Sletten, T., Middleton, B., Lederle, K., Skene, D., Roth, T., Walsh, J., Hogben, A., Ellis, J., Archer, S., von Schantz, M., Chen, N.-H., Wang, P.-C., Chen, C.-W., Lin, Y., Shih, T.-S., Armstrong, S., Redman, J., Stephan, E., David, M., Delanaud, S., Chardon, K., Libert, J.-P., Bach, V., Telliez, F., Reid, K., Jaksa, A., Eisengart, J., Kane, P., Naylor, E., Zee, P., Viola, A. U., de Valck, E., Hofmans, J., Theuns, P., Cluydts, R., Alexander, G., Karel, M., Christina, R., Sohn, I.-K., Cho, I. H., Kim, S. J., Yu, S.-H., Kim, H., Yoo, S. Y., Koh, S.-H., Cho, S.-J., Rotenberg, L., Silva-Costa, A., Griep, R. H., Amely, T., Kennedy, G. A., Pavlis, A., Thompson, B., Pierce, R., Howard, M., Briellmann, R., Venkateswaran, S., Blunden, S., Krawczyk, E., Blake, J., Gururajan, R., Kerr, D., Matuisi, T., Iwasaki, M., Yamasita, N., Iemura, A., Ohya, T., Yanagawa, T., Misa, R., Coleman, G., Conduit, R., Duce, B., Hukins, C., Nyandaiti, Y. W., Bamaki, S., Mohammed, A., Kwajarfa, S., Veeramachaneni, S. P., Murthy, A., Wilson, A., Maul, J., Hall, G., Stick, S., Moseley, L., Gradisar, M., Kurihara, T., Yamamoto, M., Yamamoto, S., Kuranari, M., Sparks, C. B., Bartle, A., Beckert, L., Latham-Smith, F. B., Hilton, J., Whitehead, B., Gulliver, T., Salvini, A., Grahame, S., Swift, M., Laybutt, N., Sharon, D., Mack, C., Hymell, B., Perrine, B., Ideshita, K., Taira, M., Matuo, A., Furutani, M., van Dongen, H., Mott, C., Huang, J.-K., Mollicone, D. J., Mckenzie, F., Dinges, David, Barnes, M., Rochford, P., Churchward, T., O’Donoghue, F., Penzel, T., Fietze, I., Canisius, S., Bekiaris, E., Terrill, P. I., Wilson, S., Suresh, S., Cooper, D., Suzuki, T., Ouchi, K., Moriya, A., Kameyama, K., Takahashi, M., Büttner, A., Rühle, K.-H., Wang, D., Wong, K., Dungan, II, G., Grunstein, R., Davidson, P., Jones, R., Gergely, V., Mashima, K., Miyazaki, S., Tanaka, T., Okawa, M., Yamada, N., Wyner, A., Raizen, D., Galante, R., Ng, A. K., Koh, T. S., Lim, L. L., Puvanendran, K., Peiris, M., Bones, P., Roebuck, T., Ho, S., Szollosi, I., Naughton, M., Williams, G., Parsley, C., Harris, M.-A., Thornton, A., Ruehland, W., Banks, S., Arroyo, S., Carroll, K., Pilmore, J., Stewart, C., Hamilton, G., van Acker, F., Cvetkovic, D., Holland, G., Cosic, I., Tolson, J., Worsnop, C., Cresswell, P., Hart, I., Bouarab, M., Delechelle, E., Drouot, X., Acebo, C., Singh, P., Lakey, T., Schachter, L., Rand, J., Collin, H., Snyder, E., Ma, J., Svetnick, V., Deacon, S., Dana, B., Konstanze, D., Uwe, M., Ingo, F., Thomas, P., Ivar, R., Mackiewicz, M., Shockley, K., Romer, M., Zimmerman, J., Baldwin, D., Jensen, S., Churchill, G., Paigen, B., Imeri, L., Ferrari, L., Bianchi, S., Dossena, S., Garofoli, A., Mangieri, M., Tagliavini, F., Forloni, G., Chiesa, R., Pedrazzoli, M., Pereira, D., Veauny, M., Bodenmann, S., Hohoff, C., Freitag, C., Deckert, J., Rétey, J., Landolt, H.-P., Strohl, K., Price, E., Yamauchi, M., Dostal, J., Feng, P., Han, F., Havekes, R., Novati, A., Hagewoud, R., Barf, P., van Der Borght, K., van Der Zee, E., Meerlo, P., Ruby, P., Caclin, A., Boulet, S., Delpuech, C., Morlet, D., Veasey, S., Aton, S., Jha, S., Coleman, T., Seibt, J., Frank, M., Lack, L., Churches, O., Feng, S. Y. S., Cassaglia, P., Yu, V. Y. H., Walker, A. M., Kohler, M., Kennedy, D., Martin, J., van Den Heuvel, C., Lushington, K., Herron, K., Khurana, C., Sterr, A., Olivadoti, M., Toth, L., Opp, M., Dang-Vu, T., Degueldre, C., Gais, S., Dang-Vu, T. T., Desseilles, M., Philips, C., Chijavadze, E., Babilodze, M., Chkhartishvili, E., Nachkebia, N., Mchedlidze, O., Dzadzamia, S., Griffiths, R., Walker, A., Horovitz, S., Fukunaga, M., Carr, W., Picchioni, D., de Zwart, J., van Gelderen, P., Braun, A., Duyn, J., Hanlon, E. H., Faraguna, U., Vyazovskiy, V., Cirelli, C., Ocampo-Garcés, A., Ibáñez, F., López, S., Vivaldi, E., Torrealba, F., Romanowski, C. P. N., Fenzl, T., Flachskamm, C., Deussing, J., Kimura, M., Tarokh, L., van Reen, E., Dorn, H., Velluti, R., Qu, W.-M., Huang, Z.-L., Hayaishi, O., Pedemonte, M., Drexler, D., Pol-Fernández, D., Bernhardt, V., Lopez, C., Rodriguez-Servetti, Z., Romanowski, C., Polta, S., Yassouridis, A., Abe, T., Takahashi, K., Koyama, Y., Kayama, Y., Lin, J.-S., Sakai, K., Gulia, K., Karashima, A., Shimazaki, M., Katayama, N., Nakao, M., Winsky-Sommerer, R., Knapman, A., Tobler, I., Altena, E., Sanz-Arigita, E., Chang, F.-C., Lu, C.-Y., Yi, P.-L., Hsiao, Y.-Z., Lowden, A., Nilsson, J., Hillert, L., Wiholm, C., Kuster, N., Arnetz, B., Szameitat, A., Shen, S., Daurat, A., Tiberge, M., Sok, N., D’Ortho, M. P. I. A., Karasinsky, P., Kohlmeier, K., Wess, J., Leonard, C., Kristensen, M., Kalinchuk, A., Porkka-Heiskanen, T., Mccarley, R. W., Basheer, R., Aizawa, R., Sunahara, H., Abe, S.-I., Iwaki, S., Houjyou, M., Satoh, M., Suda, H., Kheirandish-Gozal, L., Gozal, D., Walker, P., Noa, A., O’Driscoll, D., Ng, M., Yang, J., Davey, M., Anderson, V., Trinder, J., Horne, R., Sands, S., Kelly, V., Sia, K., Edwards, B., Skuza, E., Davidson, M., Berger, P. H. I. L. I. P., Wilkinson, M., Sánchez-Narváez, F., Gutiérrez, R., Camacho, L., Anaya, E., García-Campos, E., Labra, A., Domínguez, G., García-Polo, L., Haro, R., Verginis, N., Nixon, G., Baumert, M., Pamula, Y., Mihai, R., Wawurszak, M., Smith, N., Yiallourou, S., Andrew Ramsden, C., Williamson, B., Blecher, G., Teng, A., Dakin, C. Y. N., Yuil, M., Harris, M., Sadasivam, S., Bennison, J., Galland, B., Dawes, P., Taylor, B., Norman, M., Edwards, N., Harrison, H., Kol, C., Sullivan, C., Valladares, E., Macey, P., Kumar, R., Woo, M., Harper, R., Alger, J., Mcnamara, D., Tang, J., Goh, A., Teoh, O. H., Chiang, W. C., Chay, O. M., Marie Salvini, A., Riben, C., Blanck, A.-S., Marklund, M., Tourneux, P., Cardot, V., Leke, A., Iqbal, S. M., (Gus) Cooper, D., Witmans, M., Rodger, K., Thevasagayam, R., El-Hakim, H., Hill, C. M., Baya, A., Bucks, R., Kirkham, F., Virues-Ortega, J., Baldeweg, T., Paul, A., Hogan, A., Goodwin, J., Silva, G., Kaemingk, K., Sherrill, D., Morgan, W., Fregosi, R., Quan, S., Evans, C., Maclean, J., Waters, K., Fitzsimmons, D., Hayward, P., Fitzgerald, D., Terrill, G., O’Connell, A., Vannan, K., Richardson, H., Poluektov, M., Levin, I., Snegodskaya, M., Kolosova, N., Geppe, N., Nixon, G. Michelle, Thompson, J., Yhan, D., Becroft, D., Clark, P., Robinson, E., Waldie, K., Wild, C., Black, P., Stone, K., Britton, W., Chaves, Claudia, Tinoco, C., Goncalves, C., Ferreira, E., Santos, H., Boloto, J., Duarte, L., Paine, S., Wright, H., Slater, A., Rosen, G., Telliez, Frédéric, Djeddi, D., Kongolo, G., Degrugilliers, L., Horton, J., Buscemi, N., Vandermeer, B., Owens, J., Klassen, T., Gordon, J., King, N., Tripp, G., Oka, Y., Suzuki, S., de Lemos, M. C., Gonzaga, F. G., Shah, M. L., Bittencourt, L., Oliveira, L. V. Franco, Elshoff, J.-P., Braun, M., Andreas, J.-O., Strauss, B., Horstmann, R., Ahrweiler, S., Goldammer, N., Wada, M., Matsumoto, N., Rahman, M. D., Xu, X.-H., Makino, Y., Hashimoto, K., Zhang, M., Sastre, J.-P., Buda, C., Anaclet, C., Ohtsu, H., Danober, L., Desos, P., Cordi, A., Roger, A., Jacquet, A., Rogez, N., Thomas, J.-Y., Krentner, M., Boutin, J., Audinot-Bouchez, V., Baumann, C., Valko, P., Uhl, M., Hersberger, M., Rupp, T., Uchiyama, N., Nakamura, N., Konishi, T., Mcgrath, P., Fujiki, N., Tokunaga, J., Iijima, S., Nishino, S., Catherine, B.-R., Lely, F., Ralf, K., Oliver, N., François, J., Francois, J., Cedric, F., Changbin, Q., Patrick, H., Homanics, G., Heussler, H., Norris, R., Pache, D., Charles, B., Mcguire, T., Shelton, J., Bonaventure, P., Kelly, L., Aluisio, L., Lovenberg, T., Atack, J., Dugovic, C., Shapiro, C., Shen, J., Trajanovic, N., Chien, J., Verma, M., Fish, V., Wheatley, J., Amis, T., Alexiou, T., Wild, J., Bjursell, A., Solin, P., Sato, S., Matsubuchi, N., Gingras, M.-A., Labrosse, M., Chevrier, É, Lageix, P., Guay, M.-C., Braun, C., Godbout, R., Fatim, E. H., Loic, D., Stephane, D., Nathalie, L., Stéphane, D., Alain, G., Wiâm, R., Koabyashi, T., Tomita, S., Ishikawa, T., Manadai, O., Arakawa, K., Siato, Y., Bassi, A., Ocampo, A., Estrada, J., Blyton, D., O’Keeffe, K., Galletly, D., Larsen, P., Amatoury, J., Bilston, L., Kairaitis, K., Stephenson, R., Chu, K., Sekiguchi, Y., Suzuki, N., Yasuda, Y., Kodama, T., Honda, Y., Hsieh, K.-C., Lai, Y.-Y., Bannai, M., Kawai, N., Amici, R., Baracchi, F., Cerri, M., Del Sindaco, E., Dentico, D., Jones, C. A., Luppi, M., Martelli, D., Perez, E., Tazaki, M., Katayose, Y., Yasuda, K., Tokuyama, K., Maddison, K., Platt, P., Kirkness, J., Ware, J. C., May, J., Rosenthal, T., Park, G., Guibert, M., Allen, R. W., Cetin, T., Roman, V., Mollicone, D., Crummy, F., Cameron, P., Swann, P., Kossman, T., Taggart, F., Kandala, N.-B., Currie, A., Peile, E., Stranges, S., Marshall, N., Peltonen, M., Stenlof, K., Hedner, J., Sjostrom, L., Anderson, C., Platten, C., Jordan, K., Horne, J., Bjorkum, A., Kluge, B., Braseth, T., Gurvin, I., Kristensen, T., Nybo, R., Rosendahl, K., Nygaard, I., Biggs, S., Dollman, J., Kennedy, J. D., Martin, A. J., Haghighi, K. S., Bakht, N., Hyde, M., Harris, E., Zerouali, Y., Hosein, A., Jemel, B., Dodd, M., Rogers, N., Andersen, M., Martins, R., Alvarenga, T., Antunes, I., Papale, L., Killgore, W. S., Axelsson, J., Lekander, M., Ingre, M., Brismar, K., Dorrian, J., Ferguson, S., Jones, C., Buxton, O., Marcelli, E., Phipps-Nelson, J. O., Teixeira, L. R., de Castro Moreno, C., Turte, S. L., Nagai, R., do Rosário Dias De Oliveira Latorre, M., Marina, F., Paterson, J., Jackson, M., Johnston, P., Papafotiou, K., Croft, R., Dawson, S., Leenaars, C., Sandberg, H., Joosten, R., Dematteis, M., Feenstra, M., Wehrle, R., Rieger, M., Widmann, A., Dietl, T., Philipp, S., Wetter, T., Drummond, S., Czisch, M., Cairns, A., Lebourgeois, M., Harsh, J., Baulk, S., Vakulin, A., Catcheside, P., Antic, N., Mcevoy, D., Orff, H., Salamat, J., Meloy, M. J., Caron, A., Kostela, J., Purnell, M., Feyer, A.-M., Herbison, P., Saaresranta, T., Aittokallio, J., Karppinen, N., Toikka, J., Polo, O., Sallinen, M., Haavisto, M.-L., Hublin, C., Kiti, M., Jussi, V., Mikko, H., Chuah, L., Chee, M., Borges, F., Fischer, F., Moreno, C., Soares, N., Fonseca, M., Smolensky, M., Sackett-Lundeen, L., Haus, E., Nagata, N., Michael, N., Siccoli, M., Rogers, A., Hwang, W.-T., Scott, L., Dean, G., Geissler, E., Ametamey, S., Treyer, V., Wyss, M., Achermann, P., Schubiger, P., Theorell-Haglöw, J., Berne, C., Janson, C., Svensson, M., Lindberg, E., Caruso, H., Avinash, D., Minkel, J., Thompson, C., Wisor, J., Gerashchenko, D., Smith, K., Kuan, L., Pathak, S., Hawrylycz, M., Jones, A., Kilduff, T., Bergamo, C., Ecker, A., William, J., Niyogi, S., Coble, M., Goel, N., Lakhtman, L., Horswill, M., Whetton, M., Chambers, B., Signal, L., van Den Berg, M., Gander, P., Polotsky, V., Savransky, V., Bevans, S., Nanayakkara, A., Li, J.-G., Smith, P., Torbenson, M., Stockx, E., Brodecky, V., Berger, P., Chung-Mei Lam, J., Rial, R., Roca, C., Garau, C., Akaarir, M., Mccoy, J., Ward, C., Connolly, N., Tartar, J., Brown, R., Carberry, J., Bradford, A., O’Halloran, K., Mcguire, M., Nacher, M., Serrano-Mollar, A., Navajas, D., Farre, R., Montserrat, J., Fenik, V., Rukhadze, I., Kubin, L., Sivertsen, B., Overland, S., Mykletun, A., Czira, M., Fornádi, K., Lindner, A., Szeifert, L., Szentkirályi, A., Mucsi, I., Molnár, M., Novák, M., Zoller, R., Chin, K., Takegami, M., Oga, T., Nakayama-Asida, Y., Wakamura, T., Mishima, M., Fukuhara, S., Shepherd, K., Keir, G., Rixon, K., Makarie-Rofail, L., Unger, G., Svanborg, E., Harder, L., Sarberg, M., Broström, A., Josefsson, A., Herrera, A., Aguilera, L., Diaz, M., Fedson, A., Hung, J., Williams, C., Love, G., Middleton, S., Vermeulen, W., Middleton, P., Steinfort, D., Goldin, J., Eritaia, J., Dionysopoulos, P., Irving, L., Ciftci, T. U., Kokturk, O., Demirtas, S., Kanbay, A., Tavil, Y., Bukan, N., Demritas, S., Olsen, S., Douglas, J., Oei, T., Williams, S., Leung, S., Starmer, G., Lee, R., Chan, A., Dungan, G., Cistulli, P., Zeng, B., Bansal, A., Patial, K., Vijayan, V. K., Sonka, K., Fialova, L., Svarcova, J., Volna, J., Jiroutek, P., Pretl, M., Bartos, A., Hasegawa, R. A., Sasanabe, R., Nomura, A., Morita, M., Hori, R., Ohkura, Y., Shiomi, T. T., Collins, A., Jerums, G., Hare, D., Panagiotopoulos, S., Weatherhead, B., Bailey, M., Neil, C., Goldsworthy, U., Hill, C., Valencia-Flores, M., Resendiz, M., Juarez, S., Castano, A., Santiago, V., Aguilar, C., Ostrosky, F., Krum, H., Kaye, D., Neves, C., Decio, M., Monteiro, M., Cintra, F., Poyares, D., Viegas, C., Silva, C., Oliveira, H., Peixoto, T., Mikami, A., Watanabe, T., Kumano-Go, T., Adachi, H., Sugita, Y., Takeda, M., Oktay, B., Firat, H., Akbal, E., Ardic, S., Paim, S., Santos, R., Barrreto, A., Whitmore, H., Imperial, J., Temple, K., Rue, A., Hoffman, L., Liljenquist, D., Kazsa, K., Pavasovic, M., Copland, J., Ho, M., Jayamaha, J., Peverill, R., Hii, S., Hensley, M., Rowland, S., Windler, S., Johansson, M., Eriksson, P., Peker, Y., Råstam, L., Lindblad, U., Grote, L., Zou, D., Radlinski, J., Eder, D., Plens, C. M., Garcia Gonzaga, F. M., Farias Sa, P., Franco Oliveira, L. V., Faria Sa, P., Yoon, I.-Y., Chung, S., Hee Lee, C., Kim, J.-W., Faludi, B., Wang, X., Li, Q., Wan, H., Li, M., Pallayova, M., Donic, V., Tomori, Z., Ioacara, S., Olech, T., Mccallum, C., Bowes, M., Bowes, J., Chia, M., Gilbert, S. S., Sajkov, D., Teichtahl, H., Stevenson, I., Cunnington, D., Kalman, J., Szaboova, E., Higami, S., Kryger, M., Higami, Y., Suzuki, C., Kitano, H., Carin, S., Olof, S., Yngve, G., Gösta, B., Carlberg, B., Stenlund, H., Franklin, K. A., Oliveira, A., Vasconcelos, L., Martinez, D., Goncalves, S. C., Gus, M., Silva, E. O. A., Fuchs, S. C., Fuchs, F. D., Li, A., Au, J., Ho, C., Sung, R., Wing, Y., Tada, H., Terada, N., Togawa, K., Nakagawa, Y., Kishida, K., Kihara, S., Hirata, A., Sonoda, M., Nishizawa, H., Nakamura, T., Shimomura, I., Funahashi, T., Andrewartha, P., Sasse, A., Becker, M., Troester, N., Olschewski, H., Lisamayerkard, L., Glos, M., Blau, A., Peter, J.-G., Chesworth, W., Wilson, G., Piper, A., Chuang, L.-P., Lin, S.-W., Wang, C.-J., Li, H.-Y., Chou, Y.-T., Fu, J.-Y., Liao, Y.-F., Tsai, Y.-H., Chan, K., Laks, L., Nishibayashi, M., Miyamoto, M., Miyamoto, T., Hirata, K., Hoever, P., De Haas, S., Chiossi, E., Van Gerven, J., Dingemanse, J., Winkler, J., Cavallaro, M., Narui, K., Kasai, T., Dohl, T., Takaya, H., Kawana, F., Ueno, K., Panjwani, U., Thakur, L., Anand, J. P., Banerjee, P. K., Leigh, M., Paduch, A., Armstrong, J., Sampson, D., Kotajima, F., Mochizuki, T., Lorr, D., Harder, H., Chesworth, M., Becker, H., Abd-Elaty, N. M., Elprince, M., Ismail, N., Elserogi, W., Yeo, A., George, K., Thomson, K., Stadler, D., Bradley, J., Paul, D., Schwartz, A., Hagander, L., Harlid, R., Hultcrantz, E., Haraldsson, P., Cho, J.-G., Narayan, J., Nagarajah, M., Perri, R., Johnson, P., Burgess, K., Chau, N., Mcevoy, R. D., Arnardottir, E. S., Thorleifsdottir, B., Olafsson, I., Gislason, T., Tsuiki, S., Fujimatsu, S., Munezawa, T., Sato, Y., Subedi, P., Ainslie, P., Topor, Z., Whitelaw, W., Chan, M., So, H., Lam, H., Ng, S., Chan, I., Lam, C., Saigusa, H., Higurashi, N., He, Z. M., Cui, X. C., Li, J., Dong, X., Lv, Y., Zhou, M., Han, X., An, P., Wang, L., Macey, P. M., Serber, S., Cross, R., Yan-Go, F., Marshall, M., Rees, D., Lee, S. H., Ho Cho, J. I., Shin, C., Lee, J. Y., Kwon, S. Y., Kim, T.-H., Vedam, H., Barnes, D., Walter, H., Karin, J., Hermann, P., Belyavskiy, E., Galitsyn, P., Arbolishvili, G., Litvin, A., Chazova, I., Mareev, V., Ramar, K., Khan, A., Gay, P., Strömberg, A., Ulander, M., Fridlund, B., Mårtensson, J., Yee, B., Desai, A., Buchanan, P., Crompton, R., Melehan, K., Wong, P., Tee, A., Ng, A., Darendeliler, M. A., Ye, L., Maislin, G., Hurley, S., Mccluskey, S., Weaver, T., Yun, C.-H., Ji, K.-H., Ahn, J. Y., Lee, H.-W., Zhang, X., Yin, K., Zhaofang, G., Chong, L., Navailles, B., Zenou, E., Cheze, L., Pignat, J.-C., Tang, T., Remmers, J., Vasilakos, K., Denotti, A., Gilholme, J., Castronovo, V., Marelli, S., Aloia, M., Fantini, M. L., Kuo, T., Manconi, M., Zucconi, M., Ferini-Strambi, L., Livia Fantini, M., Giarolli, L., Oldani, A., Lee, Y., Trenell, M., Berend, N., Wang, M., Liang, Z., Lei, F., Komada, I., Nishikawa, M., Sriram, K., Mignone, L., Antic, R., Fujiwara, K., Beaudry, M., Gauthier, L., Laforte, M., Lavigne, G., Wylie, P., Orr, W., Grover, S., Geisler, P., Engelke, E., Cossa, G., Veitch, E., Brillante, R., Mcardle, N., Murphy, M., Singh, B., Gain, K., Maguire, C., Mutch, S., Brown, S., Asciuto, T., Newsam, C., Fransson, A., Ísacsson, G., Tsou, M.-C., Hsu, S.-P., Almendros, I., Acerbi, I., Vilaseca, I., Dcruz, O., Vaughn, B., Muenzer, J., Lacassagne, L., Montemayor, T., Roch-Paoli, J., Qian, J., Petocz, P., Chan, M. R., Munro, J., Zimmerman, M., Stanchina, M., Millman, R., Cassel, W., Ploch, T., Loh, A., Koehler, U., Jerrentrup, A., Greulich, T., Doyle, G., Pascoe, T., Jorgensen, G., Baglioni, C., Lombardo, C., Espie, C., Violani, C., Edell-Gustafsson, U., Swahn, E., Ejdeback, J., Tygesen, H., Johansson, A., Neckelmann, D., Hilde Nordhus, I., Zs-Kovács, Á., Vámos, E., Zs-Molnár, M., Maisuradze, L., Gugushvili, J., Darchia, N., Gvilia, I., Lortkipanidze, N., Oniani, N., Wang-Weigand, S., Mayer, G., Roth-Schechter, B., Hsu, S.-C., Yang, C.-M., Liu, C.-Y., Ito, H., Omvik, S., Nordhus, I. H., Farber, R., Scharf, M., Harris-Collazo, R., Pereira, J., Andras, S., Ohayon, M., David, B., Morgan, K., Voorn, T., Vis, J., Kuijer, J., Fortier-Brochu, E., Beaulieu-Bonneau, S., Ivers, H., Morin, C., Beaulieu-Benneau, S., Harris, J., Bartlett, D., Paisley, L., Moncada, S., Toelle, B., Bonnet, M. H., Arand, D., Bonnet, J., Bonnet, M., Doi, Y., Edéll-Gustafsson, U., Strijers, R., Fernando, A., Arroll, B., Warman, G., Funakura, M., Shikano, S., Unemoto, Y., Fujisawa, M., Hong, S.-C., Jeong, J.-H., Shin, Y.-K., Han, J.-H., Lee, S.-P., Lee, J.-H., Mignot, E., Nakajima, T., Hayashida, K., Honda, M., Ardestani, P., Etemadifar, M., Nejadnik, H., Maghzi, A. H., Basiri, K., Ebrahimi, A., Davoodi, M., Peraita-Adrados, R., Vicario, J. L., Shin, H.-B., Marti, I., Carriero, L., Fulda, S., Beitinger, P., Pollmacher, T., Lam, J. S. P., Fong, S. Y. Y., Tang, N. L. S., Ho, C. K. W., Li, A. M. C., Wing, Y. K., Guilleminault, C., Black, J., Wells, C., Kantor, S., Janisiewicz, A., Scammell, T., Tanaka, S., Smith, A., Neufing, P., Gordon, T., Fuller, P., Gompf, H., Pedersen, N., Saper, C., Lu, J., Sasai, T., Donjacour, C., Fronczek, R., Le Cessie, S., Lammers, G. J., van Dijk, J. G., Hayashi-Ogawa, Y., Okuda, M., Lam, V. K.-H., Chen, A. L., Ho, C. K.-W., Wing, Y.-K., Lehrhaft, B., Brilliante, R., van Der Zande, W., Overeem, S., van Dijk, G., Lammers, J. G., Opazo, C. J., Jeong, D.-U., Sung, Y. H., Lyoo, I. K., Takahashi, Y., Murasaki, M., Bloch, K., Jung, H., Dahab, M. M., Campos, T. F., Mccabe, S., Maravic, K., Wiggs, L., Connelly, V., Barnes, J., Saito, Y., Ogawa, M., Murata, M., Nadig, U., Rahman, A., Aritake, K., D’Cruz, O., Suzuki, K., Kaji, Y., Takekawa, H., Nomura, T., Yasui, K., Nakashima, K., Bahammam, A., Rab, M. G., Owais, S., Alsuwat, K., Hamam, K., Zs, M., Boroojerdi, B., Giladi, N., Wood, D., Sherman, D., Chaudhuri, R., Partinen, M., Abdo, F., Bloem, B., Kremer, B., Verbeek, M., Cronlein, T., Mueller, U., Hajak, G., Zulley, J., Namba, K., Li, L., Mtsuura, M., Kaneita, Y., Ohida, T., Cappeliez, B., Moutrier, R., De, S., Dwivedi, S., Chambers, D., Gabbay, E., Watanabe, A., Valle, C., Kauati, A., Watanabe, R., Chediek, F., Botte, S., Azevedo, E., Kempf, J., Cizza, G., Torvik, S., Brancati, G., Smirne, N., Bruni, A., Goff, E., Freilich, S., Malaweera, A., Simonds, A., Mathias, C., Morrell, M., Rinsky, B., Fonarow, G., Gradinger, F. P., Boldt, C., Geyh, S., Stucki, A., Dahlberg, A., Michel, F., Savard, M.-H., Savard, J., Quesnel, C., Hirose, K., Takahara, M., Mizuno, K., Sadachi, H., Nagashima, Y., Yada, Y., Cheung, C.-F., Lau, C., Lai, W., Sin, K., Tam, C., Hellgren, J., Omenaas, E., Gíslason, T., Jögi, R., Franklin, K., Torén, K., Wang, F., Kadono, M., Shigeta, M., Nakazawa, A., Ueda, M., Fukui, M., Hasegawa, G., Yoshikawa, T., de Niet, G., Tiemens, B., Lendemeijer, B., Hutschemaekers, G., Gauthier, A.-K., Chevrette, T., Chevrier, E., Bouvier, H., Parry, B., Meliska, C., Nowakowski, S., Lopez, A., Martinez, F., Sorenson, D., Lien, M. L., Lattova, Z., Maurovich-Horvat, E., Nia, S., Pollmächer, T., Poulin, J., Chouinard, S., Stip, E., Guillem, F., Venne, D., Caouette, M., Lamont, M.-E., Lázár, A., Lázár, Z., Bíró, A., Gyõri, M., Tárnok, Z., Prekop, C., Gádoros, J., Halász, P., Bódizs, R., Okun, M., Hanusa, B., Hall, M., Wisner, K., Pereira, M., Kumar, R. A. J. E. S. H., Macey, P. A. U. L., Woo, M. A. R. Y., Serber, S. T. A. C. Y., Valladares, E. D. W. I. N., Harper, R. E. B. E. C. C. A., Harper, R. O. N. A. L. D., Puttonen, S., Härmä, M., Vahtera, J., Kivimäki, M., Lamarche, L., Hemmeter, U. M., Thum, A., Rocamora, R., Giesler, M., Haag, A., Dodel, R., Krieg, J. C., Shechter, A., L’Esperance, P., Boivin, D. B., Vu, M.-T., and Richards, H.
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- 2007
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443. Conservation genetics in hypersaline inland waters: mitochondrial diversity and phylogeography of an endangered Iberian beetle (Coleoptera: Hydraenidae)
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Abellán, P., Gómez-Zurita, J., Millán, A., Sánchez-Fernández, D., Velasco, J., Galián, J., and Ribera, I.
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- 2007
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444. Spatio-temporal variation of the urban heat island in Santiago, Chile during summers 2005–2017
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Montaner-Fernández D, Morales-Salinas L, Rodriguez JS, Cárdenas-Jirón L, Huete A, Fuentes-Jaque G, Pérez-Martínez W, and Cabezas J
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0203 Classical Physics, 0406 Physical Geography and Environmental Geoscience, 0909 Geomatic Engineering - Abstract
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Urban heat islands (UHIs) can present significant risks to human health. Santiago, Chile has around 7 million residents, concentrated in an average density of 480 people/km2. During the last few summer seasons, the highest extreme maximum temperatures in over 100 years have been recorded. Given the projections in temperature increase for this metropolitan region over the next 50 years, the Santiago UHI could have an important impact on the health and stress of the general population. We studied the presence and spatial variability of UHIs in Santiago during the summer seasons from 2005 to 2017 using Moderate Resolution Imaging Spectroradiometer (MODIS) satellite imagery and data from nine meteorological stations. Simple regression models, geographic weighted regression (GWR) models and geostatistical interpolations were used to find nocturnal thermal differences in UHIs of up to 9◦ C, as well as increases in the magnitude and extension of the daytime heat island from summer 2014 to 2017. Understanding the behavior of the UHI of Santiago, Chile, is important for urban planners and local decision makers. Additionally, understanding the spatial pattern of the UHI could improve knowledge about how urban areas experience and could mitigate climate change.
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- 2020
445. 50 años del Programa de Cribado Neonatal en Cataluña
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Marín Soria JL, López Galera RM, Argudo Ramírez A, González de Aledo JM, Pajares García S, Navarro Sastre A, Hernandez Pérez JM, Ribes Rubio A, Gort Mas L, García Villoria J, Gartner Tizano S, Rovira Amigo S, Asensio de la Cruz O, García González M, Cols M, Costa-Colomer J, Bádenas Orquin C, Yeste Fernández D, Campos Martorell A, Clemente León M, Mogas Viñals E, Ferrer Costa R, Giralt Arnaiz M, Campistol-Plana J, Garcia-Cazorla A, Beneitez Pastor D, Ortuño Cabrero A, Blanco Álvarez A, Tazón Vega B, Roué G, Velasco Puyo P, Murciano Carrillo T, Murillo Sanjuan L, Díaz de Heredia Rubio C, Mañú Pereira MDM, Vives Corrons JL, Arranz Amo JA, Carnicer Cáceres C, Del Toro Riera M, Ormazábal Herrero A, Artuch-Iriberri R, García-Volpe C, de los Santos MM, Sierra-March C, Ruiz-Hernández CJ, Meavilla-Olivas SM, Martín Nalda A, Rivière JG, Parra Martínez A, Soler Palacín P, Martínez Gallo M, Colobran R, Casals Senent T, Armelles Sebastia M, Vidal Benede MJ, Jané Checa M, Fernández Bordón RM, Asso Ministral L, Prats Viedma B, and Cabezas Peña C
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Congenital hypothyroidism ,50th anniversary ,Catalonia ,Severe combined immunodeficiency ,Spain ,Sickle cell disease ,Phenylketonuria ,Inborn errors of metabolism ,Cystic fibrosis ,Newborn Screening ,Universal - Abstract
The Catalonian Newborn Screening Program (CNSP) began in 1969, in Barcelona. It was promoted by Dr. Juan Sabater Tobella and supported by Barcelona Provincial Council and Juan March Foundation. That is how the Institute of Clinical Biochemistry was born, whose aims were diagnosis, research and teaching, along with the spirit of contributing to the prevention of mental retardation. The CNSP began with the detection of phenylketonuria (PKU), and, in 1982, the Program was expanded with the inclusion of congenital hypothyroidism detection. Towards 1990, the Program covered almost 100% of all newborns (NB) in Catalonia. In 1999, the CNSP was expanded with the incorporation of cystic fibrosis. It took fourteen years, until 2013, to make the largest expansion so far, with the incorporation of 19 metabolic diseases to the screening panel. The detection of sickle cell disease began in 2015 and in 2017 the detection of severe combined immunodeficiency was included. Currently, the CNSP includes 24 diseases in its main panel. Since 1969, 2,787,807 NBs have been screened, of whom 1,724 have been diagnosed with any of these diseases, and 252 of other disorders by differential diagnosis with those included in the main panel. The global prevalence is 1: 1,617 NBs affected by any of the diseases included in the CNSP and 1: 1,140 NBs if incidental findings diagnosed through the CNSP are included.
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- 2020
446. High-Dose Corticosteroid Pulse Therapy Increases the Survival Rate in COVID-19 Patients at Risk of Cytokine Storm
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López-Vílchez M, Ocaña-Granados A, Sanchez-Palop M, Moreno-Moral A, López-Zúñiga Má, Blázquez-Roselló S, Ruz Mal, Jódar-Moreno R, Padilla-Moreno F, Castillo-Fernández Am, Martínez-Colmenero J, Prior-Sánchez I, Guillamón-Fernández D, Pimentel-Villar Ma, Ramírez-Sánchez C, and Moreno-Sánchez Jj
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medicine.medical_specialty ,medicine.drug_class ,business.industry ,Proportional hazards model ,Mortality rate ,Odds ratio ,medicine.disease ,Methylprednisolone ,Internal medicine ,Cohort ,medicine ,Corticosteroid ,business ,Cytokine storm ,Survival rate ,medicine.drug - Abstract
Background: COVID-19 is a disease caused by SARS-CoV-2, which can develop into a hyper-inflammatory late phase or “cytokine storm” that poses high risk of death. It has been proposed that the management of this cytokine storm is crucial to increase the survival rate of COVID-19 patients. However, to date there are no diagnostic criteria based on inflammatory markers that could be used to select the COVID-19 patients at risk of developing a cytokine storm or effective interventions that can decreased mortality in these patients. Methods: We carried out a quasi-experimental study to test whether high dose corticosteroid pulse therapy with either dexametaxona or methylprednisolone were associated with reduced mortality in patients at risk of cytokine storm and assess which laboratory markers can be used to pre-select these patients. To control the development and progression of this hyper-inflammtory phase, 64 patients (20.1%) were treated with high dose corticosteroid pulse therapy (HDCPT) by using either dexametaxona or methylprednisolone daily for 2-5 days at doses of at least 30mg or 125mg respectively. To determine diagnostic criteria that can be used to defined patients at risk of cytokine storm, we carried out a 30-day time course analysis of laboratory markers between survivors and non-survivors. A multivariate Cox regression (controlling for co-morbidities and therapies) was carried out to determine whether HDCPT (among other interventions) was associated with decreased mortality in both the full cohort, and in a subgroup containing the patients with the derived criteria. Findings: Out of 500 patients originally recruited, 381 met the inclusion criteria of SARS-COV-19 detection by PCR or serology (n=272, 71.2%) or high clinical suspicion (n= 46, 16.9 %), defined as having bilateral pulmonary infiltrate or lymphopenia with according clinical profile. HDCPT was the only intervention that showed a significant decrease in mortality (odds ratio = 0.093 [95% CI 0.023 – 0.38]; P = 40 pg/ml and/or two of the following: C-reactive protein >= 100 mg/L, D-dimer >= 1000 ng/ml, ferritin >= 500 ng/ml and lactate dehydrogenase >= 300 U/L. Multivariate Cox regression by pre-selecting the patients using this criteria evidenced also a decreased mortality rate with HDCPT with a lower odds ratio (odds ratio = 0.081 [95% CI 0.011 – 0.56]; P = 0.011). Conclusions: Preventing and/or controlling the development of the cytokine storm in patients at high-inflammatory risk with HDCPT is a widely available therapy to increase survival rate in these patients. We estimate a 14.2% [95% CI 0.792 - 0.975] increase of survival rate. We also suggest some initial clinical variables that can aid with the identification of the patients who will benefit from this intervention. Funding Statement: There were no funding sources in this study. Declaration of Interests: The authors declare no competing interests. Ethics Approval Statement: This study was approved by the Ethics Committee of the Complejo Hospitalario de Jaen (Hospital of Jaen), Spain (0946-N-20). According to the local ethics committee regulations, verbal consent was obtained from all the patients that joined the study.
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- 2020
447. Multimorbidity patterns in low-middle and high income regions: a multiregion latent class analysis using ATHLOS harmonised cohorts
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Bayes-Marin I, Sánchez-Niubó A, Egea-Cortés L, Nguyen H, Prina M, Fernández D, Haro JM, and Olaya B
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high-income country (HICs), latent class analysis (LCA), low- and middle-income countries (LMICs), multimorbidity, non-communicable diseases (NCDs) - Abstract
Our aim was to determine clusters of non-communicable diseases (NCDs) in a very large, population-based sample of middle-aged and older adults from low- and middle-income (LMICs) and high-income (HICs) regions. Additionally, we explored the associations with several covariates.
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- 2020
448. Palliative Care Symptoms, Outcomes, and Interventions for Chronic Advanced Patients in Spanish Nursing Homes with and without Dementia
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Puente-Fernández D, Campos-Calderón CP, Burgos AAE, Hueso-Montoro C, Roldán-López CB, and Montoya-Juárez R
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nursing ,self-efficacy ,palliative care ,validation studies ,nursing students - Abstract
The aim of this study was to compare the symptomatology, palliative care outcomes, therapeutic procedures, diagnostic tests, and pharmacological treatments for people with dementia (PWD) and without dementia (PW/OD) admitted to Spanish nursing homes. DESIGN: This was a cross-sectional study which is part of a long-term prospective follow-up of elderly people performed in nursing homes to measure end-of-life care processes. PARTICIPANTS: 107 nursing home patients with advanced or terminal chronic diseases were selected according to the criteria of the Palliative Care Spanish Society. SETTING: Two trained nurses from each nursing home were responsible for participant selection and data collection. They must have treated the residents and had a minimum seniority of 6 months in the nursing home. MEASUREMENTS: Sociodemographic data; Edmonton Symptom Assessment Scale; Palliative Care Outcome Scale; and prevalence of diagnostic tests, pharmacological treatments, and therapeutic procedures were evaluated. RESULTS: Pain, fatigue, and nausea were found to be significantly higher in the nondementia group and insomnia, poor appetite, and drowsiness were significantly higher in the dementia group. Patient anxiety, support, feeling that life was worth living, self-worth, and practical matters management were higher in the nondementia group. Regarding drugs, use of corticoids was higher in the nondementia group, while use of anxiolytics was higher in the dementia group. Diagnostic procedures such as urine analysis and X-ray were higher in the dementia group. CONCLUSIONS: Differences in symptom perception, diagnostic tests, and pharmacological procedures were found between patients with and without dementia. Specific diagnostic tools need to be developed for patients with dementia.
- Published
- 2020
449. White Paper: ARIANNA-200 high energy neutrino telescope
- Author
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Anker, A., Baldi, P., Barwick, S. W., Bergman, D., Bernhoff, H., Besson, D. Z., Bingefors, N., Botner, O., Chen, P., Chen, Y., García-Fernández, D., Gaswint, G., Glaser, C., Hallgren, A., Hanson, J. C., Huang, J. J., Klein, S. R., Kleinfelder, S. A., Kuo, C. -Y., Lahmann, R., Latif, U., Liu, T., Lyu, Y., McAleer, S., Nam, J., Novikov, A., Nelles, A., Paul, M. P., Persichilli, C., Plaisier, I., Shiao, J. Y., Tatar, J., Van Vliet, A., Wang, S. -H., Wang, Y. -H., and Welling, C.
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neutrino: energy: high ,Astrophysics::High Energy Astrophysical Phenomena ,UHE [cosmic radiation] ,ice ,FOS: Physical sciences ,Baikal ,triangulation ,IceCube ,particle source [neutrino] ,muon ,site ,showers: electromagnetic ,surface ,thrust ,cosmic radiation: UHE ,energy: high [neutrino] ,cosmic radiation: acceleration ,detector [neutrino] ,KM3NeT ,Instrumentation and Methods for Astrophysics (astro-ph.IM) ,neutrino: interaction ,radio wave ,cosmic radiation: energy spectrum ,background ,interaction [neutrino] ,Astrophysics::Instrumentation and Methods for Astrophysics ,neutrino: particle source ,sensitivity ,electromagnetic [showers] ,Auger ,neutrino: detector ,ARIANNA ,acceleration [cosmic radiation] ,Astrophysics - Instrumentation and Methods for Astrophysics ,energy spectrum [cosmic radiation] - Abstract
The proposed ARIANNA-200 neutrino detector, located at sea-level on the Ross Ice Shelf, Antarctica, consists of 200 autonomous and independent detector stations separated by 1 kilometer in a uniform triangular mesh, and serves as a pathfinder mission for the future IceCube-Gen2 project. The primary science mission of ARIANNA-200 is to search for sources of neutrinos with energies greater than 10^17 eV, complementing the reach of IceCube. An ARIANNA observation of a neutrino source would provide strong insight into the enigmatic sources of cosmic rays. ARIANNA observes the radio emission from high energy neutrino interactions in the Antarctic ice. Among radio based concepts under current investigation, ARIANNA-200 would uniquely survey the vast majority of the southern sky at any instant in time, and an important region of the northern sky, by virtue of its location on the surface of the Ross Ice Shelf in Antarctica. The broad sky coverage is specific to the Moore's Bay site, and makes ARIANNA-200 ideally suited to contribute to the multi-messenger thrust by the US National Science Foundation, Windows on the Universe - Multi-Messenger Astrophysics, providing capabilities to observe explosive sources from unknown directions. The ARIANNA architecture is designed to measure the angular direction to within 3 degrees for every neutrino candidate, which too plays an important role in the pursuit of multi-messenger observations of astrophysical sources.
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- 2020
- Full Text
- View/download PDF
450. Model-based goodness-of-fit tests for the ordered stereotype model
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Fernández D, Liu I, Arnold R, Nguyen T, and Spiess M
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ordered stereotype model ,ordinal data ,Goodness of fit ,uneven spacing ,Hosmer–Lemeshow test - Abstract
This paper presents two new model-based goodness-of-fit tests for the ordered stereotype model applied to an ordinal response variable. The proposed tests are based on the Lipsitz test, which partitions the subjects into G groups following the popular Hosmer-Lemeshow test for binary data. The tests construct an alternative model where group effects are added into the null model. If the model fits the data well then the null model is correct, and there should be no group effects. One of the main advantages of the ordered stereotype model is that it allows us to determine a new uneven spacing of the ordinal response categories, dictated by the data. The two proposed tests use this new adjusted spacing. One test uses the form of the original ordered stereotype model, and the other uses an ordinary linear model. We demonstrate the performance of both tests under a variety of scenarios. Finally, the results of the application in three examples are presented.
- Published
- 2020
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