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1,627 results on '"Dorronsoro, Miren"'

401. Selenium status is associated with colorectal cancer risk in the European prospective investigation of cancer and nutrition cohort

Author: Hughes, David J., Fedirko, Veronika, Jenab, Mazda, Schomburg, Lutz, Meplan, Catherine, Freisling, Heinz, Bueno-de-Mesquita, H. B(as), Hybsier, Sandra, Becker, Niels-Peter, Czuban, Magdalena, Tjonneland, Anne, Outzen, Malene, Boutron-Ruault, Marie-Christine, Racine, Antoine, Bastide, Nadia, Kuehn, Tilman, Kaaks, Rudolf, Trichopoulos, Dimitrios, Trichopoulou, Antonia, Lagiou, Pagona, Panico, Salvatore, Peeters, Petra H., Weiderpass, Elisabete, Skeie, Guri, Dagrun, Engeset, Chirlaque, Maria-Dolores, Sanchez, Maria-Jose, Ardanaz, Eva, Ljuslinder, Ingrid, Wennberg, Maria, Bradbury, Kathryn E., Vineis, Paolo, Naccarati, Alessio, Palli, Domenico, Boeing, Heiner, Overvad, Kim, Dorronsoro, Miren, Jakszyn, Paula, Cross, Amanda J., Quiros, Jose Ramon, Stepien, Magdalena, Kong, So Yeon, Duarte-Salles, Talita, Riboli, Elio, Hesketh, John E., Hughes, David J., Fedirko, Veronika, Jenab, Mazda, Schomburg, Lutz, Meplan, Catherine, Freisling, Heinz, Bueno-de-Mesquita, H. B(as), Hybsier, Sandra, Becker, Niels-Peter, Czuban, Magdalena, Tjonneland, Anne, Outzen, Malene, Boutron-Ruault, Marie-Christine, Racine, Antoine, Bastide, Nadia, Kuehn, Tilman, Kaaks, Rudolf, Trichopoulos, Dimitrios, Trichopoulou, Antonia, Lagiou, Pagona, Panico, Salvatore, Peeters, Petra H., Weiderpass, Elisabete, Skeie, Guri, Dagrun, Engeset, Chirlaque, Maria-Dolores, Sanchez, Maria-Jose, Ardanaz, Eva, Ljuslinder, Ingrid, Wennberg, Maria, Bradbury, Kathryn E., Vineis, Paolo, Naccarati, Alessio, Palli, Domenico, Boeing, Heiner, Overvad, Kim, Dorronsoro, Miren, Jakszyn, Paula, Cross, Amanda J., Quiros, Jose Ramon, Stepien, Magdalena, Kong, So Yeon, Duarte-Salles, Talita, Riboli, Elio, and Hesketh, John E.
Published: 2015

402. Pre-diagnostic concordance with the WCRF/AICR guidelines and survival in European colorectal cancer patients

Author: University of Helsinki, Department of Medical Genetics, Romaguera, Dora, Ward, Heather, Wark, Petra A., Vergnaud, Anne-Claire, Peeters, Petra H., van Gils, Carla H., Ferrari, Pietro, Fedirko, Veronika, Jenab, Mazda, Boutron-Ruault, Marie-Christine, Dossus, Laure, Dartois, Laureen, Hansen, Camilla Plambeck, Dahm, Christina Catherine, Buckland, Genevieve, Sanchez, Maria Jose, Dorronsoro, Miren, Navarro, Carmen, Barricarte, Aurelio, Key, Timothy J., Trichopoulou, Antonia, Tsironis, Christos, Lagiou, Pagona, Masala, Giovanna, Pala, Valeria, Tumino, Rosario, Vineis, Paolo, Panico, Salvatore, Bueno-de-Mesquita, H. Bas, Siersema, Peter D., Ohlsson, Bodil, Jirstrom, Karin, Wennberg, Maria, Nilsson, Lena M., Weiderpass, Elisabete, Kuehn, Tilman, Katzke, Verena, Khaw, Kay-Tee, Wareham, Nick J., Tjonneland, Anne, Boeing, Heiner, Quiros, Jose R., Gunter, Marc J., Riboli, Elio, Norat, Teresa, University of Helsinki, Department of Medical Genetics, Romaguera, Dora, Ward, Heather, Wark, Petra A., Vergnaud, Anne-Claire, Peeters, Petra H., van Gils, Carla H., Ferrari, Pietro, Fedirko, Veronika, Jenab, Mazda, Boutron-Ruault, Marie-Christine, Dossus, Laure, Dartois, Laureen, Hansen, Camilla Plambeck, Dahm, Christina Catherine, Buckland, Genevieve, Sanchez, Maria Jose, Dorronsoro, Miren, Navarro, Carmen, Barricarte, Aurelio, Key, Timothy J., Trichopoulou, Antonia, Tsironis, Christos, Lagiou, Pagona, Masala, Giovanna, Pala, Valeria, Tumino, Rosario, Vineis, Paolo, Panico, Salvatore, Bueno-de-Mesquita, H. Bas, Siersema, Peter D., Ohlsson, Bodil, Jirstrom, Karin, Wennberg, Maria, Nilsson, Lena M., Weiderpass, Elisabete, Kuehn, Tilman, Katzke, Verena, Khaw, Kay-Tee, Wareham, Nick J., Tjonneland, Anne, Boeing, Heiner, Quiros, Jose R., Gunter, Marc J., Riboli, Elio, and Norat, Teresa
Abstract: Background: Cancer survivors are advised to follow lifestyle recommendations on diet, physical activity, and body fatness proposed by the World Cancer Research Fund/American Institute of Cancer Research (WCRF/AICR) for cancer prevention. Previous studies have demonstrated that higher concordance with these recommendations measured using an index score (the WCRF/AICR score) was associated with lower cancer incidence and mortality. The aim of this study was to evaluate the association between pre-diagnostic concordance with WCRF/AICR recommendations and mortality in colorectal cancer (CRC) patients. Methods: The association between the WCRF/AICR score (score range 0-6 in men and 0-7 in women; higher scores indicate greater concordance) assessed on average 6.4 years before diagnosis and CRC-specific (n = 872) and overall mortality (n = 1,113) was prospectively examined among 3,292 participants diagnosed with CRC in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort (mean follow-up time after diagnosis 4.2 years). Multivariable Cox proportional hazard models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for mortality. Results: The HRs (95% CIs) for CRC-specific mortality among participants in the second (score range in men/women: 2.25-2.75/3.25-3.75), third (3-3.75/4-4.75), and fourth (4-6/5-7) categories of the score were 0.87 (0.72-1.06), 0.74 (0.61-0.90), and 0.70 (0.56-0.89), respectively (P for trend Conclusions: Greater concordance with the WCRF/AICR recommendations on diet, physical activity, and body fatness prior to CRC diagnosis is associated with improved survival among CRC patients.
Published: 2015

403. Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for Thirteen Cancer Types

Author: Infection & Immunity, dIRAS RA-I&I RA, LS IRAS EEPI GRA (Gezh.risico-analyse), Risk Assessment, Sampson, Joshua N, Wheeler, William A, Yeager, Meredith, Panagiotou, Orestis, Wang, Zhaoming, Berndt, Sonja I, Lan, Qing, Abnet, Christian C, Amundadottir, Laufey T, Figueroa, Jonine D, Landi, Maria Teresa, Mirabello, Lisa, Savage, Sharon A, Taylor, Philip R, Vivo, Immaculata De, McGlynn, Katherine A, Purdue, Mark P, Rajaraman, Preetha, Adami, Hans-Olov, Ahlbom, Anders, Albanes, Demetrius, Amary, Maria Fernanda, An, She-Juan, Andersson, Ulrika, Andriole, Gerald, Andrulis, Irene L, Angelucci, Emanuele, Ansell, Stephen M, Arici, Cecilia, Armstrong, Bruce K, Arslan, Alan A, Austin, Melissa A, Baris, Dalsu, Barkauskas, Donald A, Bassig, Bryan A, Becker, Nikolaus, Benavente, Yolanda, Benhamou, Simone, Berg, Christine, Van Den Berg, David, Bernstein, Leslie, Bertrand, Kimberly A, Birmann, Brenda M, Black, Amanda, Boeing, Heiner, Boffetta, Paolo, Boutron-Ruault, Marie-Christine, Bracci, Paige M, Brinton, Louise, Brooks-Wilson, Angela R, Bueno-de-Mesquita, H Bas, Burdett, Laurie, Buring, Julie, Butler, Mary Ann, Cai, Qiuyin, Cancel-Tassin, Geraldine, Canzian, Federico, Carrato, Alfredo, Carreon, Tania, Carta, Angela, Chan, John K C, Chang, Ellen T, Chang, Gee-Chen, Chang, I-Shou, Chang, Jiang, Chang-Claude, Jenny, Chen, Chien-Jen, Chen, Chih-Yi, Chen, Chu, Chen, Chung-Hsing, Chen, Constance, Chen, Hongyan, Chen, Kexin, Chen, Kuan-Yu, Chen, Kun-Chieh, Chen, Ying, Chen, Ying-Hsiang, Chen, Yi-Song, Chen, Yuh-Min, Chien, Li-Hsin, Chirlaque, María-Dolores, Choi, Jin Eun, Choi, Yi Young, Chow, Wong-Ho, Chung, Charles C, Clavel, Jacqueline, Clavel-Chapelon, Françoise, Cocco, Pierluigi, Colt, Joanne S, Comperat, Eva, Conde, Lucia, Connors, Joseph M, Conti, David, Cortessis, Victoria K, Cotterchio, Michelle, Cozen, Wendy, Crouch, Simon, Crous-Bou, Marta, Cussenot, Olivier, Davis, Faith G, Ding, Ti, Diver, W Ryan, Dorronsoro, Miren, Dossus, Laure, Duell, Eric J, Ennas, Maria Grazia, Erickson, Ralph L, Feychting, Maria, Flanagan, Adrienne M, Foretova, Lenka, Fraumeni, Joseph F, Freedman, Neal D, Beane Freeman, Laura E, Fuchs, Charles, Gago-Dominguez, Manuela, Gallinger, Steven, Gao, Yu-Tang, Gapstur, Susan M, Garcia-Closas, Montserrat, García-Closas, Reina, Gascoyne, Randy D, Gastier-Foster, Julie, Gaudet, Mia M, Gaziano, J Michael, Giffen, Carol, Giles, Graham G, Giovannucci, Edward, Glimelius, Bengt, Goggins, Michael, Gokgoz, Nalan, Goldstein, Alisa M, Gorlick, Richard, Gross, Myron, Grubb, Robert, Gu, Jian, Guan, Peng, Gunter, Marc, Guo, Huan, Habermann, Thomas M, Haiman, Christopher A, Halai, Dina, Hallmans, Goran, Hassan, Manal, Hattinger, Claudia, He, Qincheng, He, Xingzhou, Helzlsouer, Kathy, Henderson, Brian, Henriksson, Roger, Hjalgrim, Henrik, Hoffman-Bolton, Judith, Hohensee, Chancellor, Holford, Theodore R, Holly, Elizabeth A, Hong, Yun-Chul, Hoover, Robert N, Horn-Ross, Pamela L, Hosain, G M Monawar, Hosgood, H Dean, Hsiao, Chin-Fu, Hu, Nan, Hu, Wei, Hu, Zhibin, Huang, Ming-Shyan, Huerta, Jose-Maria, Hung, Jen-Yu, Hutchinson, Amy, Inskip, Peter D, Jackson, Rebecca D, Jacobs, Eric J, Jenab, Mazda, Jeon, Hyo-Sung, Ji, Bu-Tian, Jin, Guangfu, Jin, Li, Johansen, Christoffer, Johnson, Alison, Jung, Yoo Jin, Kaaks, Rudolph, Kamineni, Aruna, Kane, Eleanor, Kang, Chang Hyun, Karagas, Margaret R, Kelly, Rachel S, Khaw, Kay-Tee, Kim, Christopher, Kim, Hee Nam, Kim, Jin Hee, Kim, Jun Suk, Kim, Yeul Hong, Kim, Young Tae, Kim, Young-Chul, Kitahara, Cari M, Klein, Alison P, Klein, Robert J, Kogevinas, Manolis, Kohno, Takashi, Kolonel, Laurence N, Kooperberg, Charles, Kricker, Anne, Krogh, Vittorio, Kunitoh, Hideo, Kurtz, Robert C, Kweon, Sun-Seog, LaCroix, Andrea, Lawrence, Charles, Lecanda, Fernando, Lee, Victor Ho Fun, Li, Donghui, Li, Haixin, Li, Jihua, Li, Yao-Jen, Li, Yuqing, Liao, Linda M, Liebow, Mark, Lightfoot, Tracy, Lim, Wei-Yen, Lin, Chien-Chung, Lin, Dongxin, Lindstrom, Sara, Linet, Martha S, Link, Brian K, Liu, Chenwei, Liu, Jianjun, Liu, Li, Ljungberg, Börje, Lloreta, Josep, Lollo, Simonetta Di, Lu, Daru, Lund, Eiluv, Malats, Nuria, Mannisto, Satu, Marchand, Loic Le, Marina, Neyssa, Masala, Giovanna, Mastrangelo, Giuseppe, Matsuo, Keitaro, Maynadie, Marc, McKay, James, McKean-Cowdin, Roberta, Melbye, Mads, Melin, Beatrice S, Michaud, Dominique S, Mitsudomi, Tetsuya, Monnereau, Alain, Montalvan, Rebecca, Moore, Lee E, Mortensen, Lotte Maxild, Nieters, Alexandra, North, Kari E, Novak, Anne J, Oberg, Ann L, Offit, Kenneth, Oh, In-Jae, Olson, Sara H, Palli, Domenico, Pao, William, Park, In Kyu, Park, Jae Yong, Park, Kyong Hwa, Patiño-Garcia, Ana, Pavanello, Sofia, Peeters, Petra H M, Perng, Reury-Perng, Peters, Ulrike, Petersen, Gloria M, Picci, Piero, Pike, Malcolm C, Porru, Stefano, Prescott, Jennifer, Prokunina-Olsson, Ludmila, Qian, Biyun, Qiao, You-Lin, Rais, Marco, Riboli, Elio, Riby, Jacques, Risch, Harvey A, Rizzato, Cosmeri, Rodabough, Rebecca, Roman, Eve, Roupret, Morgan, Ruder, Avima M, Sanjose, Silvia de, Scelo, Ghislaine, Schned, Alan, Schumacher, Fredrick, Schwartz, Kendra, Schwenn, Molly, Scotlandi, Katia, Seow, Adeline, Serra, Consol, Serra, Massimo, Sesso, Howard D, Setiawan, Veronica Wendy, Severi, Gianluca, Severson, Richard K, Shanafelt, Tait D, Shen, Hongbing, Shen, Wei, Shin, Min-Ho, Shiraishi, Kouya, Shu, Xiao-Ou, Siddiq, Afshan, Sierrasesúmaga, Luis, Sihoe, Alan Dart Loon, Skibola, Christine F, Smith, Alex, Smith, Martyn T, Southey, Melissa C, Spinelli, John J, Staines, Anthony, Stampfer, Meir, Stern, Marianna C, Stevens, Victoria L, Stolzenberg-Solomon, Rachael S, Su, Jian, Su, Wu-Chou, Sund, Malin, Sung, Jae Sook, Sung, Sook Whan, Tan, Wen, Tang, Wei, Tardón, Adonina, Thomas, David, Thompson, Carrie A, Tinker, Lesley F, Tirabosco, Roberto, Tjønneland, Anne, Travis, Ruth C, Trichopoulos, Dimitrios, Tsai, Fang-Yu, Tsai, Ying-Huang, Tucker, Margaret, Turner, Jenny, Vajdic, Claire M, Vermeulen, Roel C H, Villano, Danylo J, Vineis, Paolo, Virtamo, Jarmo, Visvanathan, Kala, Wactawski-Wende, Jean, Wang, Chaoyu, Wang, Chih-Liang, Wang, Jiu-Cun, Wang, Junwen, Wei, Fusheng, Weiderpass, Elisabete, Weiner, George J, Weinstein, Stephanie, Wentzensen, Nicolas, White, Emily, Witzig, Thomas E, Wolpin, Brian M, Wong, Maria Pik, Wu, Chen, Wu, Guoping, Wu, Junjie, Wu, Tangchun, Wu, Wei, Wu, Xifeng, Wu, Yi-Long, Wunder, Jay S, Xiang, Yong-Bing, Xu, Jun, Xu, Ping, Yang, Pan-Chyr, Yang, Tsung-Ying, Ye, Yuanqing, Yin, Zhihua, Yokota, Jun, Yoon, Ho-Il, Yu, Chong-Jen, Yu, Herbert, Yu, Kai, Yuan, Jian-Min, Zelenetz, Andrew, Zeleniuch-Jacquotte, Anne, Zhang, Xu-Chao, Zhang, Yawei, Zhao, Xueying, Zhao, Zhenhong, Zheng, Hong, Zheng, Tongzhang, Zheng, Wei, Zhou, Baosen, Zhu, Meng, Zucca, Mariagrazia, Boca, Simina M, Cerhan, James R, Ferri, Giovanni M, Hartge, Patricia, Hsiung, Chao Agnes, Magnani, Corrado, Miligi, Lucia, Morton, Lindsay M, Smedby, Karin E, Teras, Lauren R, Vijai, Joseph, Wang, Sophia S, Brennan, Paul, Caporaso, Neil E, Hunter, David J, Kraft, Peter, Rothman, Nathaniel, Silverman, Debra T, Slager, Susan L, Chanock, Stephen J, Chatterjee, Nilanjan, Infection & Immunity, dIRAS RA-I&I RA, LS IRAS EEPI GRA (Gezh.risico-analyse), Risk Assessment, Sampson, Joshua N, Wheeler, William A, Yeager, Meredith, Panagiotou, Orestis, Wang, Zhaoming, Berndt, Sonja I, Lan, Qing, Abnet, Christian C, Amundadottir, Laufey T, Figueroa, Jonine D, Landi, Maria Teresa, Mirabello, Lisa, Savage, Sharon A, Taylor, Philip R, Vivo, Immaculata De, McGlynn, Katherine A, Purdue, Mark P, Rajaraman, Preetha, Adami, Hans-Olov, Ahlbom, Anders, Albanes, Demetrius, Amary, Maria Fernanda, An, She-Juan, Andersson, Ulrika, Andriole, Gerald, Andrulis, Irene L, Angelucci, Emanuele, Ansell, Stephen M, Arici, Cecilia, Armstrong, Bruce K, Arslan, Alan A, Austin, Melissa A, Baris, Dalsu, Barkauskas, Donald A, Bassig, Bryan A, Becker, Nikolaus, Benavente, Yolanda, Benhamou, Simone, Berg, Christine, Van Den Berg, David, Bernstein, Leslie, Bertrand, Kimberly A, Birmann, Brenda M, Black, Amanda, Boeing, Heiner, Boffetta, Paolo, Boutron-Ruault, Marie-Christine, Bracci, Paige M, Brinton, Louise, Brooks-Wilson, Angela R, Bueno-de-Mesquita, H Bas, Burdett, Laurie, Buring, Julie, Butler, Mary Ann, Cai, Qiuyin, Cancel-Tassin, Geraldine, Canzian, Federico, Carrato, Alfredo, Carreon, Tania, Carta, Angela, Chan, John K C, Chang, Ellen T, Chang, Gee-Chen, Chang, I-Shou, Chang, Jiang, Chang-Claude, Jenny, Chen, Chien-Jen, Chen, Chih-Yi, Chen, Chu, Chen, Chung-Hsing, Chen, Constance, Chen, Hongyan, Chen, Kexin, Chen, Kuan-Yu, Chen, Kun-Chieh, Chen, Ying, Chen, Ying-Hsiang, Chen, Yi-Song, Chen, Yuh-Min, Chien, Li-Hsin, Chirlaque, María-Dolores, Choi, Jin Eun, Choi, Yi Young, Chow, Wong-Ho, Chung, Charles C, Clavel, Jacqueline, Clavel-Chapelon, Françoise, Cocco, Pierluigi, Colt, Joanne S, Comperat, Eva, Conde, Lucia, Connors, Joseph M, Conti, David, Cortessis, Victoria K, Cotterchio, Michelle, Cozen, Wendy, Crouch, Simon, Crous-Bou, Marta, Cussenot, Olivier, Davis, Faith G, Ding, Ti, Diver, W Ryan, Dorronsoro, Miren, Dossus, Laure, Duell, Eric J, Ennas, Maria Grazia, Erickson, Ralph L, Feychting, Maria, Flanagan, Adrienne M, Foretova, Lenka, Fraumeni, Joseph F, Freedman, Neal D, Beane Freeman, Laura E, Fuchs, Charles, Gago-Dominguez, Manuela, Gallinger, Steven, Gao, Yu-Tang, Gapstur, Susan M, Garcia-Closas, Montserrat, García-Closas, Reina, Gascoyne, Randy D, Gastier-Foster, Julie, Gaudet, Mia M, Gaziano, J Michael, Giffen, Carol, Giles, Graham G, Giovannucci, Edward, Glimelius, Bengt, Goggins, Michael, Gokgoz, Nalan, Goldstein, Alisa M, Gorlick, Richard, Gross, Myron, Grubb, Robert, Gu, Jian, Guan, Peng, Gunter, Marc, Guo, Huan, Habermann, Thomas M, Haiman, Christopher A, Halai, Dina, Hallmans, Goran, Hassan, Manal, Hattinger, Claudia, He, Qincheng, He, Xingzhou, Helzlsouer, Kathy, Henderson, Brian, Henriksson, Roger, Hjalgrim, Henrik, Hoffman-Bolton, Judith, Hohensee, Chancellor, Holford, Theodore R, Holly, Elizabeth A, Hong, Yun-Chul, Hoover, Robert N, Horn-Ross, Pamela L, Hosain, G M Monawar, Hosgood, H Dean, Hsiao, Chin-Fu, Hu, Nan, Hu, Wei, Hu, Zhibin, Huang, Ming-Shyan, Huerta, Jose-Maria, Hung, Jen-Yu, Hutchinson, Amy, Inskip, Peter D, Jackson, Rebecca D, Jacobs, Eric J, Jenab, Mazda, Jeon, Hyo-Sung, Ji, Bu-Tian, Jin, Guangfu, Jin, Li, Johansen, Christoffer, Johnson, Alison, Jung, Yoo Jin, Kaaks, Rudolph, Kamineni, Aruna, Kane, Eleanor, Kang, Chang Hyun, Karagas, Margaret R, Kelly, Rachel S, Khaw, Kay-Tee, Kim, Christopher, Kim, Hee Nam, Kim, Jin Hee, Kim, Jun Suk, Kim, Yeul Hong, Kim, Young Tae, Kim, Young-Chul, Kitahara, Cari M, Klein, Alison P, Klein, Robert J, Kogevinas, Manolis, Kohno, Takashi, Kolonel, Laurence N, Kooperberg, Charles, Kricker, Anne, Krogh, Vittorio, Kunitoh, Hideo, Kurtz, Robert C, Kweon, Sun-Seog, LaCroix, Andrea, Lawrence, Charles, Lecanda, Fernando, Lee, Victor Ho Fun, Li, Donghui, Li, Haixin, Li, Jihua, Li, Yao-Jen, Li, Yuqing, Liao, Linda M, Liebow, Mark, Lightfoot, Tracy, Lim, Wei-Yen, Lin, Chien-Chung, Lin, Dongxin, Lindstrom, Sara, Linet, Martha S, Link, Brian K, Liu, Chenwei, Liu, Jianjun, Liu, Li, Ljungberg, Börje, Lloreta, Josep, Lollo, Simonetta Di, Lu, Daru, Lund, Eiluv, Malats, Nuria, Mannisto, Satu, Marchand, Loic Le, Marina, Neyssa, Masala, Giovanna, Mastrangelo, Giuseppe, Matsuo, Keitaro, Maynadie, Marc, McKay, James, McKean-Cowdin, Roberta, Melbye, Mads, Melin, Beatrice S, Michaud, Dominique S, Mitsudomi, Tetsuya, Monnereau, Alain, Montalvan, Rebecca, Moore, Lee E, Mortensen, Lotte Maxild, Nieters, Alexandra, North, Kari E, Novak, Anne J, Oberg, Ann L, Offit, Kenneth, Oh, In-Jae, Olson, Sara H, Palli, Domenico, Pao, William, Park, In Kyu, Park, Jae Yong, Park, Kyong Hwa, Patiño-Garcia, Ana, Pavanello, Sofia, Peeters, Petra H M, Perng, Reury-Perng, Peters, Ulrike, Petersen, Gloria M, Picci, Piero, Pike, Malcolm C, Porru, Stefano, Prescott, Jennifer, Prokunina-Olsson, Ludmila, Qian, Biyun, Qiao, You-Lin, Rais, Marco, Riboli, Elio, Riby, Jacques, Risch, Harvey A, Rizzato, Cosmeri, Rodabough, Rebecca, Roman, Eve, Roupret, Morgan, Ruder, Avima M, Sanjose, Silvia de, Scelo, Ghislaine, Schned, Alan, Schumacher, Fredrick, Schwartz, Kendra, Schwenn, Molly, Scotlandi, Katia, Seow, Adeline, Serra, Consol, Serra, Massimo, Sesso, Howard D, Setiawan, Veronica Wendy, Severi, Gianluca, Severson, Richard K, Shanafelt, Tait D, Shen, Hongbing, Shen, Wei, Shin, Min-Ho, Shiraishi, Kouya, Shu, Xiao-Ou, Siddiq, Afshan, Sierrasesúmaga, Luis, Sihoe, Alan Dart Loon, Skibola, Christine F, Smith, Alex, Smith, Martyn T, Southey, Melissa C, Spinelli, John J, Staines, Anthony, Stampfer, Meir, Stern, Marianna C, Stevens, Victoria L, Stolzenberg-Solomon, Rachael S, Su, Jian, Su, Wu-Chou, Sund, Malin, Sung, Jae Sook, Sung, Sook Whan, Tan, Wen, Tang, Wei, Tardón, Adonina, Thomas, David, Thompson, Carrie A, Tinker, Lesley F, Tirabosco, Roberto, Tjønneland, Anne, Travis, Ruth C, Trichopoulos, Dimitrios, Tsai, Fang-Yu, Tsai, Ying-Huang, Tucker, Margaret, Turner, Jenny, Vajdic, Claire M, Vermeulen, Roel C H, Villano, Danylo J, Vineis, Paolo, Virtamo, Jarmo, Visvanathan, Kala, Wactawski-Wende, Jean, Wang, Chaoyu, Wang, Chih-Liang, Wang, Jiu-Cun, Wang, Junwen, Wei, Fusheng, Weiderpass, Elisabete, Weiner, George J, Weinstein, Stephanie, Wentzensen, Nicolas, White, Emily, Witzig, Thomas E, Wolpin, Brian M, Wong, Maria Pik, Wu, Chen, Wu, Guoping, Wu, Junjie, Wu, Tangchun, Wu, Wei, Wu, Xifeng, Wu, Yi-Long, Wunder, Jay S, Xiang, Yong-Bing, Xu, Jun, Xu, Ping, Yang, Pan-Chyr, Yang, Tsung-Ying, Ye, Yuanqing, Yin, Zhihua, Yokota, Jun, Yoon, Ho-Il, Yu, Chong-Jen, Yu, Herbert, Yu, Kai, Yuan, Jian-Min, Zelenetz, Andrew, Zeleniuch-Jacquotte, Anne, Zhang, Xu-Chao, Zhang, Yawei, Zhao, Xueying, Zhao, Zhenhong, Zheng, Hong, Zheng, Tongzhang, Zheng, Wei, Zhou, Baosen, Zhu, Meng, Zucca, Mariagrazia, Boca, Simina M, Cerhan, James R, Ferri, Giovanni M, Hartge, Patricia, Hsiung, Chao Agnes, Magnani, Corrado, Miligi, Lucia, Morton, Lindsay M, Smedby, Karin E, Teras, Lauren R, Vijai, Joseph, Wang, Sophia S, Brennan, Paul, Caporaso, Neil E, Hunter, David J, Kraft, Peter, Rothman, Nathaniel, Silverman, Debra T, Slager, Susan L, Chanock, Stephen J, and Chatterjee, Nilanjan
Published: 2015

404. Subtypes of fruit and vegetables, variety in consumption and risk of colon and rectal cancer in the European Prospective Investigation into Cancer and Nutrition

Author: Risk Assessment, Infection & Immunity, dIRAS RA-I&I RA, LS IRAS EEPI GRA (Gezh.risico-analyse), Leenders, Max, Siersema, Peter D, Overvad, Kim, Tjønneland, Anne, Olsen, Anja, Boutron-Ruault, Marie-Christine, Bastide, Nadia, Fagherazzi, Guy, Katzke, Verena, Kühn, Tilman, Boeing, Heiner, Aleksandrova, Krasimira, Trichopoulou, Antonia, Lagiou, Pagona, Klinaki, Eleni, Masala, Giovanna, Grioni, Sara, De Magistris, Maria Santucci, Tumino, Rosario, Ricceri, Fulvio, Peeters, Petra H M, Lund, Eiliv, Skeie, Guri, Weiderpass, Elisabete, Quirós, J Ramón, Agudo, Antonio, Sánchez, María-José, Dorronsoro, Miren, Navarro, Carmen, Ardanaz, Eva, Ohlsson, Bodil, Jirström, Karin, Van Guelpen, Bethany, Wennberg, Maria, Khaw, Kay-Tee, Wareham, Nick, Key, Timothy J, Romieu, Isabelle, Huybrechts, Inge, Cross, Amanda J, Murphy, Neil, Riboli, Elio, Bueno-de-Mesquita, H Bas, Risk Assessment, Infection & Immunity, dIRAS RA-I&I RA, LS IRAS EEPI GRA (Gezh.risico-analyse), Leenders, Max, Siersema, Peter D, Overvad, Kim, Tjønneland, Anne, Olsen, Anja, Boutron-Ruault, Marie-Christine, Bastide, Nadia, Fagherazzi, Guy, Katzke, Verena, Kühn, Tilman, Boeing, Heiner, Aleksandrova, Krasimira, Trichopoulou, Antonia, Lagiou, Pagona, Klinaki, Eleni, Masala, Giovanna, Grioni, Sara, De Magistris, Maria Santucci, Tumino, Rosario, Ricceri, Fulvio, Peeters, Petra H M, Lund, Eiliv, Skeie, Guri, Weiderpass, Elisabete, Quirós, J Ramón, Agudo, Antonio, Sánchez, María-José, Dorronsoro, Miren, Navarro, Carmen, Ardanaz, Eva, Ohlsson, Bodil, Jirström, Karin, Van Guelpen, Bethany, Wennberg, Maria, Khaw, Kay-Tee, Wareham, Nick, Key, Timothy J, Romieu, Isabelle, Huybrechts, Inge, Cross, Amanda J, Murphy, Neil, Riboli, Elio, and Bueno-de-Mesquita, H Bas
Published: 2015

405. Determinants of the t(14;18) translocation and their role in t(14;18)-positive follicular lymphoma

Author: Infection & Immunity, Risk Assessment, dIRAS RA-I&I RA, LS IRAS EEPI GRA (Gezh.risico-analyse), Kelly, Rachel S, Roulland, Sandrine, Morgado, Ester, Sungalee, Stéphanie, Jouve, Nathalie, Tumino, Rosario, Krogh, Vittorio, Panico, Salvatore, Polidoro, Silvia, Masala, Giovanna, Sánchez, María-José, Chirlaque, Maria-Dolores, Sala, Núria, Gurrea, Aurelio Barricarte, Dorronsoro, Miren, Travis, Ruth C, Riboli, Elio, Gunter, Marc, Murphy, Neil, Vermeulen, Roel, Bueno-de-Mesquita, H B, Peeters, Petra H, Trichopoulou, Antonia, Trichopoulos, Dimitrios, Lagiou, Pagona, Nieters, Alexandra, Canzian, Federico, Kaaks, Rudolf, Boeing, Heiner, Weiderpass, Elisabete, Stocks, Tanja, Melin, Beatrice, Overvad, Kim, Tjønneland, Anne, Olsen, Anja, Brennan, Paul, Johansson, Mattias, Nadel, Bertrand, Vineis, Paolo, Infection & Immunity, Risk Assessment, dIRAS RA-I&I RA, LS IRAS EEPI GRA (Gezh.risico-analyse), Kelly, Rachel S, Roulland, Sandrine, Morgado, Ester, Sungalee, Stéphanie, Jouve, Nathalie, Tumino, Rosario, Krogh, Vittorio, Panico, Salvatore, Polidoro, Silvia, Masala, Giovanna, Sánchez, María-José, Chirlaque, Maria-Dolores, Sala, Núria, Gurrea, Aurelio Barricarte, Dorronsoro, Miren, Travis, Ruth C, Riboli, Elio, Gunter, Marc, Murphy, Neil, Vermeulen, Roel, Bueno-de-Mesquita, H B, Peeters, Petra H, Trichopoulou, Antonia, Trichopoulos, Dimitrios, Lagiou, Pagona, Nieters, Alexandra, Canzian, Federico, Kaaks, Rudolf, Boeing, Heiner, Weiderpass, Elisabete, Stocks, Tanja, Melin, Beatrice, Overvad, Kim, Tjønneland, Anne, Olsen, Anja, Brennan, Paul, Johansson, Mattias, Nadel, Bertrand, and Vineis, Paolo
Published: 2015

406. Coffee, tea and decaffeinated coffee in relation to hepatocellular carcinoma in a European population: Multicentre, prospective cohort study

Author: MS MDL 1, Cancer, Epi Kanker Team A, JC onderzoeksprogramma Kanker, Cardiovasculaire Epi Team 4, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Bamia, Christina, Lagiou, Pagona, Jenab, Mazda, Trichopoulou, Antonia, Fedirko, Veronika, Aleksandrova, Krasimira, Pischon, Tobias, Overvad, Kim, Olsen, Anja, Tjonneland, Anne, Boutron-Ruault, Marie-Christine, Fagherazzi, Guy, Racine, Antoine, Kuhn, Tilman, Boeing, Heiner, Floegel, Anna, Benetou, Vasiliki, Palli, Domenico, Grioni, Sara, Panico, Salvatore, Tumino, Rosario, Vineis, Paolo, Bueno-de-Mesquita, H. B. (as), Dik, Vincent K., Bhoo Pathy, Nirmala, Uiterwaal, Cuno S.P.M., Weiderpass, Elisabete, Lund, Eiliv, Quiros, J. Ramon, Zamora-Ros, Raul, Molina-Montes, Esther, Chirlaque, Maria-Dolores, Ardanaz, Eva, Dorronsoro, Miren, Lindkvist, Bjoern, Wallstroem, Peter, Nilsson, Lena Maria, Sund, Malin, Khaw, Kay-Tee, Wareham, Nick, Bradbury, Kathryn E., Travis, Ruth C., Ferrari, Pietro, Duarte-Salles, Talita, Stepien, Magdalena, Gunter, Marc, Murphy, Neil, Riboli, Elio, Trichopoulos, Dimitrios, MS MDL 1, Cancer, Epi Kanker Team A, JC onderzoeksprogramma Kanker, Cardiovasculaire Epi Team 4, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Bamia, Christina, Lagiou, Pagona, Jenab, Mazda, Trichopoulou, Antonia, Fedirko, Veronika, Aleksandrova, Krasimira, Pischon, Tobias, Overvad, Kim, Olsen, Anja, Tjonneland, Anne, Boutron-Ruault, Marie-Christine, Fagherazzi, Guy, Racine, Antoine, Kuhn, Tilman, Boeing, Heiner, Floegel, Anna, Benetou, Vasiliki, Palli, Domenico, Grioni, Sara, Panico, Salvatore, Tumino, Rosario, Vineis, Paolo, Bueno-de-Mesquita, H. B. (as), Dik, Vincent K., Bhoo Pathy, Nirmala, Uiterwaal, Cuno S.P.M., Weiderpass, Elisabete, Lund, Eiliv, Quiros, J. Ramon, Zamora-Ros, Raul, Molina-Montes, Esther, Chirlaque, Maria-Dolores, Ardanaz, Eva, Dorronsoro, Miren, Lindkvist, Bjoern, Wallstroem, Peter, Nilsson, Lena Maria, Sund, Malin, Khaw, Kay-Tee, Wareham, Nick, Bradbury, Kathryn E., Travis, Ruth C., Ferrari, Pietro, Duarte-Salles, Talita, Stepien, Magdalena, Gunter, Marc, Murphy, Neil, Riboli, Elio, and Trichopoulos, Dimitrios
Published: 2015

407. The association between glyceraldehyde-derived advanced glycation end-products and colorectal cancer risk

Author: Cancer, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Kong, So Yeon, Takeuchi, Masayoshi, Hyogo, Hideyuki, McKeown-Eyssen, Gail, Yamagishi, Sho Ichi, Chayama, Kazuaki, O'Brien, Peter J., Ferrari, Pietro, Overvad, Kim, Olsen, Anja, Tjønneland, Anne, Boutron-Ruault, Marie Christine, Bastide, Nadia, Carbonnel, Franck, Kühn, Tilman, Kaaks, Rudolf, Boeing, Heiner, Aleksandrova, Krasimira, Trichopoulou, Antonia, Lagiou, Pagona, Vasilopoulou, Effie, Masala, Giovanna, Pala, Valeria, De Magistris, Maria Santucci, Tumino, Rosario, Naccarati, Alessio, Bueno-De-Mesquita, H. B., Peeters, Petra H., Weiderpass, Elisabete, Quiŕos, J. Ramón, Jakszyn, Paula, ͆anchez, María Jos̈e, Dorronsoro, Miren, Gavrila, Diana, Ardanaz, Eva, Rutegård, Martin, Nyström, Hanna, Wareham, Nicholas J., Khaw, Kay Tee, Bradbury, Kathryn E., Romieu, Isabelle, Freisling, Heinz, Stavropoulou, Faidra, Gunter, Marc J., Cross, Amanda J., Riboli, Elio, Jenab, Mazda, Bruce, W. Robert, Cancer, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Kong, So Yeon, Takeuchi, Masayoshi, Hyogo, Hideyuki, McKeown-Eyssen, Gail, Yamagishi, Sho Ichi, Chayama, Kazuaki, O'Brien, Peter J., Ferrari, Pietro, Overvad, Kim, Olsen, Anja, Tjønneland, Anne, Boutron-Ruault, Marie Christine, Bastide, Nadia, Carbonnel, Franck, Kühn, Tilman, Kaaks, Rudolf, Boeing, Heiner, Aleksandrova, Krasimira, Trichopoulou, Antonia, Lagiou, Pagona, Vasilopoulou, Effie, Masala, Giovanna, Pala, Valeria, De Magistris, Maria Santucci, Tumino, Rosario, Naccarati, Alessio, Bueno-De-Mesquita, H. B., Peeters, Petra H., Weiderpass, Elisabete, Quiŕos, J. Ramón, Jakszyn, Paula, ͆anchez, María Jos̈e, Dorronsoro, Miren, Gavrila, Diana, Ardanaz, Eva, Rutegård, Martin, Nyström, Hanna, Wareham, Nicholas J., Khaw, Kay Tee, Bradbury, Kathryn E., Romieu, Isabelle, Freisling, Heinz, Stavropoulou, Faidra, Gunter, Marc J., Cross, Amanda J., Riboli, Elio, Jenab, Mazda, and Bruce, W. Robert
Published: 2015

408. General and abdominal obesity and risk of esophageal and gastric adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition

Author: Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Cancer, Steffen, Annika, Huerta, José-Maria, Weiderpass, Elisabete, Bueno-de-Mesquita, H B As, May, Anne M, Siersema, Peter D, Kaaks, Rudolf, Neamat-Allah, Jasmine, Pala, Valeria, Panico, Salvatore, Saieva, Calogero, Tumino, Rosario, Naccarati, Alessio, Dorronsoro, Miren, Sánchez-Cantalejo, Emilio, Ardanaz, Eva, Quirós, J Ramón, Ohlsson, Bodil, Johansson, Mattias, Wallner, Bengt, Overvad, Kim, Halkjaer, Jytte, Tjønneland, Anne, Fagherazzi, Guy, Racine, Antoine, Clavel-Chapelon, Françoise, Key, Tim J, Khaw, Kay-Tee, Wareham, Nick, Lagiou, Pagona, Bamia, Christina, Trichopoulou, Antonia, Ferrari, Pietro, Freisling, Heinz, Lu, Yunxia, Riboli, Elio, Cross, Amanda J, Gonzalez, Carlos A, Boeing, Heiner, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Cancer, Steffen, Annika, Huerta, José-Maria, Weiderpass, Elisabete, Bueno-de-Mesquita, H B As, May, Anne M, Siersema, Peter D, Kaaks, Rudolf, Neamat-Allah, Jasmine, Pala, Valeria, Panico, Salvatore, Saieva, Calogero, Tumino, Rosario, Naccarati, Alessio, Dorronsoro, Miren, Sánchez-Cantalejo, Emilio, Ardanaz, Eva, Quirós, J Ramón, Ohlsson, Bodil, Johansson, Mattias, Wallner, Bengt, Overvad, Kim, Halkjaer, Jytte, Tjønneland, Anne, Fagherazzi, Guy, Racine, Antoine, Clavel-Chapelon, Françoise, Key, Tim J, Khaw, Kay-Tee, Wareham, Nick, Lagiou, Pagona, Bamia, Christina, Trichopoulou, Antonia, Ferrari, Pietro, Freisling, Heinz, Lu, Yunxia, Riboli, Elio, Cross, Amanda J, Gonzalez, Carlos A, and Boeing, Heiner
Published: 2015

409. Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for Thirteen Cancer Types

Author: Cancer, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Sampson, Joshua N, Wheeler, William A, Yeager, Meredith, Panagiotou, Orestis, Wang, Zhaoming, Berndt, Sonja I, Lan, Qing, Abnet, Christian C, Amundadottir, Laufey T, Figueroa, Jonine D, Landi, Maria Teresa, Mirabello, Lisa, Savage, Sharon A, Taylor, Philip R, Vivo, Immaculata De, McGlynn, Katherine A, Purdue, Mark P, Rajaraman, Preetha, Adami, Hans-Olov, Ahlbom, Anders, Albanes, Demetrius, Amary, Maria Fernanda, An, She-Juan, Andersson, Ulrika, Andriole, Gerald, Andrulis, Irene L, Angelucci, Emanuele, Ansell, Stephen M, Arici, Cecilia, Armstrong, Bruce K, Arslan, Alan A, Austin, Melissa A, Baris, Dalsu, Barkauskas, Donald A, Bassig, Bryan A, Becker, Nikolaus, Benavente, Yolanda, Benhamou, Simone, Berg, Christine, Van Den Berg, David, Bernstein, Leslie, Bertrand, Kimberly A, Birmann, Brenda M, Black, Amanda, Boeing, Heiner, Boffetta, Paolo, Boutron-Ruault, Marie-Christine, Bracci, Paige M, Brinton, Louise, Brooks-Wilson, Angela R, Bueno-de-Mesquita, H Bas, Burdett, Laurie, Buring, Julie, Butler, Mary Ann, Cai, Qiuyin, Cancel-Tassin, Geraldine, Canzian, Federico, Carrato, Alfredo, Carreon, Tania, Carta, Angela, Chan, John K C, Chang, Ellen T, Chang, Gee-Chen, Chang, I-Shou, Chang, Jiang, Chang-Claude, Jenny, Chen, Chien-Jen, Chen, Chih-Yi, Chen, Chu, Chen, Chung-Hsing, Chen, Constance, Chen, Hongyan, Chen, Kexin, Chen, Kuan-Yu, Chen, Kun-Chieh, Chen, Ying, Chen, Ying-Hsiang, Chen, Yi-Song, Chen, Yuh-Min, Chien, Li-Hsin, Chirlaque, María-Dolores, Choi, Jin Eun, Choi, Yi Young, Chow, Wong-Ho, Chung, Charles C, Clavel, Jacqueline, Clavel-Chapelon, Françoise, Cocco, Pierluigi, Colt, Joanne S, Comperat, Eva, Conde, Lucia, Connors, Joseph M, Conti, David, Cortessis, Victoria K, Cotterchio, Michelle, Cozen, Wendy, Crouch, Simon, Crous-Bou, Marta, Cussenot, Olivier, Davis, Faith G, Ding, Ti, Diver, W Ryan, Dorronsoro, Miren, Dossus, Laure, Duell, Eric J, Ennas, Maria Grazia, Erickson, Ralph L, Feychting, Maria, Flanagan, Adrienne M, Foretova, Lenka, Fraumeni, Joseph F, Freedman, Neal D, Beane Freeman, Laura E, Fuchs, Charles, Gago-Dominguez, Manuela, Gallinger, Steven, Gao, Yu-Tang, Gapstur, Susan M, Garcia-Closas, Montserrat, García-Closas, Reina, Gascoyne, Randy D, Gastier-Foster, Julie, Gaudet, Mia M, Gaziano, J Michael, Giffen, Carol, Giles, Graham G, Giovannucci, Edward, Glimelius, Bengt, Goggins, Michael, Gokgoz, Nalan, Goldstein, Alisa M, Gorlick, Richard, Gross, Myron, Grubb, Robert, Gu, Jian, Guan, Peng, Gunter, Marc, Guo, Huan, Habermann, Thomas M, Haiman, Christopher A, Halai, Dina, Hallmans, Goran, Hassan, Manal, Hattinger, Claudia, He, Qincheng, He, Xingzhou, Helzlsouer, Kathy, Henderson, Brian, Henriksson, Roger, Hjalgrim, Henrik, Hoffman-Bolton, Judith, Hohensee, Chancellor, Holford, Theodore R, Holly, Elizabeth A, Hong, Yun-Chul, Hoover, Robert N, Horn-Ross, Pamela L, Hosain, G M Monawar, Hosgood, H Dean, Hsiao, Chin-Fu, Hu, Nan, Hu, Wei, Hu, Zhibin, Huang, Ming-Shyan, Huerta, Jose-Maria, Hung, Jen-Yu, Hutchinson, Amy, Inskip, Peter D, Jackson, Rebecca D, Jacobs, Eric J, Jenab, Mazda, Jeon, Hyo-Sung, Ji, Bu-Tian, Jin, Guangfu, Jin, Li, Johansen, Christoffer, Johnson, Alison, Jung, Yoo Jin, Kaaks, Rudolph, Kamineni, Aruna, Kane, Eleanor, Kang, Chang Hyun, Karagas, Margaret R, Kelly, Rachel S, Khaw, Kay-Tee, Kim, Christopher, Kim, Hee Nam, Kim, Jin Hee, Kim, Jun Suk, Kim, Yeul Hong, Kim, Young Tae, Kim, Young-Chul, Kitahara, Cari M, Klein, Alison P, Klein, Robert J, Kogevinas, Manolis, Kohno, Takashi, Kolonel, Laurence N, Kooperberg, Charles, Kricker, Anne, Krogh, Vittorio, Kunitoh, Hideo, Kurtz, Robert C, Kweon, Sun-Seog, LaCroix, Andrea, Lawrence, Charles, Lecanda, Fernando, Lee, Victor Ho Fun, Li, Donghui, Li, Haixin, Li, Jihua, Li, Yao-Jen, Li, Yuqing, Liao, Linda M, Liebow, Mark, Lightfoot, Tracy, Lim, Wei-Yen, Lin, Chien-Chung, Lin, Dongxin, Lindstrom, Sara, Linet, Martha S, Link, Brian K, Liu, Chenwei, Liu, Jianjun, Liu, Li, Ljungberg, Börje, Lloreta, Josep, Lollo, Simonetta Di, Lu, Daru, Lund, Eiluv, Malats, Nuria, Mannisto, Satu, Marchand, Loic Le, Marina, Neyssa, Masala, Giovanna, Mastrangelo, Giuseppe, Matsuo, Keitaro, Maynadie, Marc, McKay, James, McKean-Cowdin, Roberta, Melbye, Mads, Melin, Beatrice S, Michaud, Dominique S, Mitsudomi, Tetsuya, Monnereau, Alain, Montalvan, Rebecca, Moore, Lee E, Mortensen, Lotte Maxild, Nieters, Alexandra, North, Kari E, Novak, Anne J, Oberg, Ann L, Offit, Kenneth, Oh, In-Jae, Olson, Sara H, Palli, Domenico, Pao, William, Park, In Kyu, Park, Jae Yong, Park, Kyong Hwa, Patiño-Garcia, Ana, Pavanello, Sofia, Peeters, Petra H M, Perng, Reury-Perng, Peters, Ulrike, Petersen, Gloria M, Picci, Piero, Pike, Malcolm C, Porru, Stefano, Prescott, Jennifer, Prokunina-Olsson, Ludmila, Qian, Biyun, Qiao, You-Lin, Rais, Marco, Riboli, Elio, Riby, Jacques, Risch, Harvey A, Rizzato, Cosmeri, Rodabough, Rebecca, Roman, Eve, Roupret, Morgan, Ruder, Avima M, Sanjose, Silvia de, Scelo, Ghislaine, Schned, Alan, Schumacher, Fredrick, Schwartz, Kendra, Schwenn, Molly, Scotlandi, Katia, Seow, Adeline, Serra, Consol, Serra, Massimo, Sesso, Howard D, Setiawan, Veronica Wendy, Severi, Gianluca, Severson, Richard K, Shanafelt, Tait D, Shen, Hongbing, Shen, Wei, Shin, Min-Ho, Shiraishi, Kouya, Shu, Xiao-Ou, Siddiq, Afshan, Sierrasesúmaga, Luis, Sihoe, Alan Dart Loon, Skibola, Christine F, Smith, Alex, Smith, Martyn T, Southey, Melissa C, Spinelli, John J, Staines, Anthony, Stampfer, Meir, Stern, Marianna C, Stevens, Victoria L, Stolzenberg-Solomon, Rachael S, Su, Jian, Su, Wu-Chou, Sund, Malin, Sung, Jae Sook, Sung, Sook Whan, Tan, Wen, Tang, Wei, Tardón, Adonina, Thomas, David, Thompson, Carrie A, Tinker, Lesley F, Tirabosco, Roberto, Tjønneland, Anne, Travis, Ruth C, Trichopoulos, Dimitrios, Tsai, Fang-Yu, Tsai, Ying-Huang, Tucker, Margaret, Turner, Jenny, Vajdic, Claire M, Vermeulen, Roel C H, Villano, Danylo J, Vineis, Paolo, Virtamo, Jarmo, Visvanathan, Kala, Wactawski-Wende, Jean, Wang, Chaoyu, Wang, Chih-Liang, Wang, Jiu-Cun, Wang, Junwen, Wei, Fusheng, Weiderpass, Elisabete, Weiner, George J, Weinstein, Stephanie, Wentzensen, Nicolas, White, Emily, Witzig, Thomas E, Wolpin, Brian M, Wong, Maria Pik, Wu, Chen, Wu, Guoping, Wu, Junjie, Wu, Tangchun, Wu, Wei, Wu, Xifeng, Wu, Yi-Long, Wunder, Jay S, Xiang, Yong-Bing, Xu, Jun, Xu, Ping, Yang, Pan-Chyr, Yang, Tsung-Ying, Ye, Yuanqing, Yin, Zhihua, Yokota, Jun, Yoon, Ho-Il, Yu, Chong-Jen, Yu, Herbert, Yu, Kai, Yuan, Jian-Min, Zelenetz, Andrew, Zeleniuch-Jacquotte, Anne, Zhang, Xu-Chao, Zhang, Yawei, Zhao, Xueying, Zhao, Zhenhong, Zheng, Hong, Zheng, Tongzhang, Zheng, Wei, Zhou, Baosen, Zhu, Meng, Zucca, Mariagrazia, Boca, Simina M, Cerhan, James R, Ferri, Giovanni M, Hartge, Patricia, Hsiung, Chao Agnes, Magnani, Corrado, Miligi, Lucia, Morton, Lindsay M, Smedby, Karin E, Teras, Lauren R, Vijai, Joseph, Wang, Sophia S, Brennan, Paul, Caporaso, Neil E, Hunter, David J, Kraft, Peter, Rothman, Nathaniel, Silverman, Debra T, Slager, Susan L, Chanock, Stephen J, Chatterjee, Nilanjan, Cancer, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Sampson, Joshua N, Wheeler, William A, Yeager, Meredith, Panagiotou, Orestis, Wang, Zhaoming, Berndt, Sonja I, Lan, Qing, Abnet, Christian C, Amundadottir, Laufey T, Figueroa, Jonine D, Landi, Maria Teresa, Mirabello, Lisa, Savage, Sharon A, Taylor, Philip R, Vivo, Immaculata De, McGlynn, Katherine A, Purdue, Mark P, Rajaraman, Preetha, Adami, Hans-Olov, Ahlbom, Anders, Albanes, Demetrius, Amary, Maria Fernanda, An, She-Juan, Andersson, Ulrika, Andriole, Gerald, Andrulis, Irene L, Angelucci, Emanuele, Ansell, Stephen M, Arici, Cecilia, Armstrong, Bruce K, Arslan, Alan A, Austin, Melissa A, Baris, Dalsu, Barkauskas, Donald A, Bassig, Bryan A, Becker, Nikolaus, Benavente, Yolanda, Benhamou, Simone, Berg, Christine, Van Den Berg, David, Bernstein, Leslie, Bertrand, Kimberly A, Birmann, Brenda M, Black, Amanda, Boeing, Heiner, Boffetta, Paolo, Boutron-Ruault, Marie-Christine, Bracci, Paige M, Brinton, Louise, Brooks-Wilson, Angela R, Bueno-de-Mesquita, H Bas, Burdett, Laurie, Buring, Julie, Butler, Mary Ann, Cai, Qiuyin, Cancel-Tassin, Geraldine, Canzian, Federico, Carrato, Alfredo, Carreon, Tania, Carta, Angela, Chan, John K C, Chang, Ellen T, Chang, Gee-Chen, Chang, I-Shou, Chang, Jiang, Chang-Claude, Jenny, Chen, Chien-Jen, Chen, Chih-Yi, Chen, Chu, Chen, Chung-Hsing, Chen, Constance, Chen, Hongyan, Chen, Kexin, Chen, Kuan-Yu, Chen, Kun-Chieh, Chen, Ying, Chen, Ying-Hsiang, Chen, Yi-Song, Chen, Yuh-Min, Chien, Li-Hsin, Chirlaque, María-Dolores, Choi, Jin Eun, Choi, Yi Young, Chow, Wong-Ho, Chung, Charles C, Clavel, Jacqueline, Clavel-Chapelon, Françoise, Cocco, Pierluigi, Colt, Joanne S, Comperat, Eva, Conde, Lucia, Connors, Joseph M, Conti, David, Cortessis, Victoria K, Cotterchio, Michelle, Cozen, Wendy, Crouch, Simon, Crous-Bou, Marta, Cussenot, Olivier, Davis, Faith G, Ding, Ti, Diver, W Ryan, Dorronsoro, Miren, Dossus, Laure, Duell, Eric J, Ennas, Maria Grazia, Erickson, Ralph L, Feychting, Maria, Flanagan, Adrienne M, Foretova, Lenka, Fraumeni, Joseph F, Freedman, Neal D, Beane Freeman, Laura E, Fuchs, Charles, Gago-Dominguez, Manuela, Gallinger, Steven, Gao, Yu-Tang, Gapstur, Susan M, Garcia-Closas, Montserrat, García-Closas, Reina, Gascoyne, Randy D, Gastier-Foster, Julie, Gaudet, Mia M, Gaziano, J Michael, Giffen, Carol, Giles, Graham G, Giovannucci, Edward, Glimelius, Bengt, Goggins, Michael, Gokgoz, Nalan, Goldstein, Alisa M, Gorlick, Richard, Gross, Myron, Grubb, Robert, Gu, Jian, Guan, Peng, Gunter, Marc, Guo, Huan, Habermann, Thomas M, Haiman, Christopher A, Halai, Dina, Hallmans, Goran, Hassan, Manal, Hattinger, Claudia, He, Qincheng, He, Xingzhou, Helzlsouer, Kathy, Henderson, Brian, Henriksson, Roger, Hjalgrim, Henrik, Hoffman-Bolton, Judith, Hohensee, Chancellor, Holford, Theodore R, Holly, Elizabeth A, Hong, Yun-Chul, Hoover, Robert N, Horn-Ross, Pamela L, Hosain, G M Monawar, Hosgood, H Dean, Hsiao, Chin-Fu, Hu, Nan, Hu, Wei, Hu, Zhibin, Huang, Ming-Shyan, Huerta, Jose-Maria, Hung, Jen-Yu, Hutchinson, Amy, Inskip, Peter D, Jackson, Rebecca D, Jacobs, Eric J, Jenab, Mazda, Jeon, Hyo-Sung, Ji, Bu-Tian, Jin, Guangfu, Jin, Li, Johansen, Christoffer, Johnson, Alison, Jung, Yoo Jin, Kaaks, Rudolph, Kamineni, Aruna, Kane, Eleanor, Kang, Chang Hyun, Karagas, Margaret R, Kelly, Rachel S, Khaw, Kay-Tee, Kim, Christopher, Kim, Hee Nam, Kim, Jin Hee, Kim, Jun Suk, Kim, Yeul Hong, Kim, Young Tae, Kim, Young-Chul, Kitahara, Cari M, Klein, Alison P, Klein, Robert J, Kogevinas, Manolis, Kohno, Takashi, Kolonel, Laurence N, Kooperberg, Charles, Kricker, Anne, Krogh, Vittorio, Kunitoh, Hideo, Kurtz, Robert C, Kweon, Sun-Seog, LaCroix, Andrea, Lawrence, Charles, Lecanda, Fernando, Lee, Victor Ho Fun, Li, Donghui, Li, Haixin, Li, Jihua, Li, Yao-Jen, Li, Yuqing, Liao, Linda M, Liebow, Mark, Lightfoot, Tracy, Lim, Wei-Yen, Lin, Chien-Chung, Lin, Dongxin, Lindstrom, Sara, Linet, Martha S, Link, Brian K, Liu, Chenwei, Liu, Jianjun, Liu, Li, Ljungberg, Börje, Lloreta, Josep, Lollo, Simonetta Di, Lu, Daru, Lund, Eiluv, Malats, Nuria, Mannisto, Satu, Marchand, Loic Le, Marina, Neyssa, Masala, Giovanna, Mastrangelo, Giuseppe, Matsuo, Keitaro, Maynadie, Marc, McKay, James, McKean-Cowdin, Roberta, Melbye, Mads, Melin, Beatrice S, Michaud, Dominique S, Mitsudomi, Tetsuya, Monnereau, Alain, Montalvan, Rebecca, Moore, Lee E, Mortensen, Lotte Maxild, Nieters, Alexandra, North, Kari E, Novak, Anne J, Oberg, Ann L, Offit, Kenneth, Oh, In-Jae, Olson, Sara H, Palli, Domenico, Pao, William, Park, In Kyu, Park, Jae Yong, Park, Kyong Hwa, Patiño-Garcia, Ana, Pavanello, Sofia, Peeters, Petra H M, Perng, Reury-Perng, Peters, Ulrike, Petersen, Gloria M, Picci, Piero, Pike, Malcolm C, Porru, Stefano, Prescott, Jennifer, Prokunina-Olsson, Ludmila, Qian, Biyun, Qiao, You-Lin, Rais, Marco, Riboli, Elio, Riby, Jacques, Risch, Harvey A, Rizzato, Cosmeri, Rodabough, Rebecca, Roman, Eve, Roupret, Morgan, Ruder, Avima M, Sanjose, Silvia de, Scelo, Ghislaine, Schned, Alan, Schumacher, Fredrick, Schwartz, Kendra, Schwenn, Molly, Scotlandi, Katia, Seow, Adeline, Serra, Consol, Serra, Massimo, Sesso, Howard D, Setiawan, Veronica Wendy, Severi, Gianluca, Severson, Richard K, Shanafelt, Tait D, Shen, Hongbing, Shen, Wei, Shin, Min-Ho, Shiraishi, Kouya, Shu, Xiao-Ou, Siddiq, Afshan, Sierrasesúmaga, Luis, Sihoe, Alan Dart Loon, Skibola, Christine F, Smith, Alex, Smith, Martyn T, Southey, Melissa C, Spinelli, John J, Staines, Anthony, Stampfer, Meir, Stern, Marianna C, Stevens, Victoria L, Stolzenberg-Solomon, Rachael S, Su, Jian, Su, Wu-Chou, Sund, Malin, Sung, Jae Sook, Sung, Sook Whan, Tan, Wen, Tang, Wei, Tardón, Adonina, Thomas, David, Thompson, Carrie A, Tinker, Lesley F, Tirabosco, Roberto, Tjønneland, Anne, Travis, Ruth C, Trichopoulos, Dimitrios, Tsai, Fang-Yu, Tsai, Ying-Huang, Tucker, Margaret, Turner, Jenny, Vajdic, Claire M, Vermeulen, Roel C H, Villano, Danylo J, Vineis, Paolo, Virtamo, Jarmo, Visvanathan, Kala, Wactawski-Wende, Jean, Wang, Chaoyu, Wang, Chih-Liang, Wang, Jiu-Cun, Wang, Junwen, Wei, Fusheng, Weiderpass, Elisabete, Weiner, George J, Weinstein, Stephanie, Wentzensen, Nicolas, White, Emily, Witzig, Thomas E, Wolpin, Brian M, Wong, Maria Pik, Wu, Chen, Wu, Guoping, Wu, Junjie, Wu, Tangchun, Wu, Wei, Wu, Xifeng, Wu, Yi-Long, Wunder, Jay S, Xiang, Yong-Bing, Xu, Jun, Xu, Ping, Yang, Pan-Chyr, Yang, Tsung-Ying, Ye, Yuanqing, Yin, Zhihua, Yokota, Jun, Yoon, Ho-Il, Yu, Chong-Jen, Yu, Herbert, Yu, Kai, Yuan, Jian-Min, Zelenetz, Andrew, Zeleniuch-Jacquotte, Anne, Zhang, Xu-Chao, Zhang, Yawei, Zhao, Xueying, Zhao, Zhenhong, Zheng, Hong, Zheng, Tongzhang, Zheng, Wei, Zhou, Baosen, Zhu, Meng, Zucca, Mariagrazia, Boca, Simina M, Cerhan, James R, Ferri, Giovanni M, Hartge, Patricia, Hsiung, Chao Agnes, Magnani, Corrado, Miligi, Lucia, Morton, Lindsay M, Smedby, Karin E, Teras, Lauren R, Vijai, Joseph, Wang, Sophia S, Brennan, Paul, Caporaso, Neil E, Hunter, David J, Kraft, Peter, Rothman, Nathaniel, Silverman, Debra T, Slager, Susan L, Chanock, Stephen J, and Chatterjee, Nilanjan
Published: 2015

410. The association of coffee intake with liver cancer risk is mediated by biomarkers of inflammation and hepatocellular injury: Data from the European Prospective Investigation into Cancer and Nutrition

Author: Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Cancer, Infection & Immunity, Aleksandrova, Krasimira, Bamia, Christina, Drogan, Dagmar, Lagiou, Pagona, Trichopoulou, Antonia, Jenab, Mazda, Fedirko, Veronika, Romieu, Isabelle, Bueno-De-Mesquita, H. Bas, Pischon, Tobias, Tsilidis, Kostas, Overvad, Kim, Tjønneland, Anne, Bouton-Ruault, Marie Christine, Dossus, Laure, Racine, Antoine, Kaaks, Rudolf, Kühn, Tilman, Tsironis, Christos, Papatesta, Eleni Maria, Saitakis, George, Palli, Domenico, Panico, Salvatore, Grioni, Sara, Tumino, Rosario, Vineis, Paolo, Peeters, Petra H., Weiderpass, Elisabete, Lukic, Marko, Braaten, Tonje, Quirós, J. Ramón, Luján-Barroso, Leila, Sánchez, María José, Chilarque, Maria Dolores, Ardanas, Eva, Dorronsoro, Miren, Maria Nilsson, Lena, Sund, Malin, Wallström, Peter, Ohlsson, Bodil, Bradbury, Kathryn E., Khaw, Kay Tee, Wareham, Nick, Stepien, Magdalena, Duarte-Salles, Talita, Assi, Nada, Murphy, Neil, Gunter, Marc J., Riboli, Elio, Boeing, Heiner, Trichopoulos, Dimitrios, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Cancer, Infection & Immunity, Aleksandrova, Krasimira, Bamia, Christina, Drogan, Dagmar, Lagiou, Pagona, Trichopoulou, Antonia, Jenab, Mazda, Fedirko, Veronika, Romieu, Isabelle, Bueno-De-Mesquita, H. Bas, Pischon, Tobias, Tsilidis, Kostas, Overvad, Kim, Tjønneland, Anne, Bouton-Ruault, Marie Christine, Dossus, Laure, Racine, Antoine, Kaaks, Rudolf, Kühn, Tilman, Tsironis, Christos, Papatesta, Eleni Maria, Saitakis, George, Palli, Domenico, Panico, Salvatore, Grioni, Sara, Tumino, Rosario, Vineis, Paolo, Peeters, Petra H., Weiderpass, Elisabete, Lukic, Marko, Braaten, Tonje, Quirós, J. Ramón, Luján-Barroso, Leila, Sánchez, María José, Chilarque, Maria Dolores, Ardanas, Eva, Dorronsoro, Miren, Maria Nilsson, Lena, Sund, Malin, Wallström, Peter, Ohlsson, Bodil, Bradbury, Kathryn E., Khaw, Kay Tee, Wareham, Nick, Stepien, Magdalena, Duarte-Salles, Talita, Assi, Nada, Murphy, Neil, Gunter, Marc J., Riboli, Elio, Boeing, Heiner, and Trichopoulos, Dimitrios
Published: 2015

411. Subtypes of fruit and vegetables, variety in consumption and risk of colon and rectal cancer in the European Prospective Investigation into Cancer and Nutrition

Author: MS MDL 1, Cancer, MS MDL Oncologie, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Leenders, Max, Siersema, Peter D., Overvad, Kim, Tjønneland, Anne, Olsen, Anja, Boutron-Ruault, Marie Christine, Bastide, Nadia, Fagherazzi, Guy, Katzke, Verena, Kühn, Tilman, Boeing, Heiner, Aleksandrova, Krasimira, Trichopoulou, Antonia, Lagiou, Pagona, Klinaki, Eleni, Masala, Giovanna, Grioni, Sara, Santucci De Magistris, Maria, Tumino, Rosario, Ricceri, Fulvio, Peeters, Petra H M, Lund, Eiliv, Skeie, Guri, Weiderpass, Elisabete, Quirõs, J. Ramõn, Agudo, Antonio, Sánchez, María José, Dorronsoro, Miren, Navarro, Carmen, Ardanaz, Eva, Ohlsson, Bodil, Jirström, Karin, Van Guelpen, Bethany, Wennberg, Maria, Khaw, Kay Tee, Wareham, Nick, Key, Timothy J., Romieu, Isabelle, Huybrechts, Inge, Cross, Amanda J., Murphy, Neil, Riboli, Elio, Bueno-De-Mesquita, H., MS MDL 1, Cancer, MS MDL Oncologie, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Leenders, Max, Siersema, Peter D., Overvad, Kim, Tjønneland, Anne, Olsen, Anja, Boutron-Ruault, Marie Christine, Bastide, Nadia, Fagherazzi, Guy, Katzke, Verena, Kühn, Tilman, Boeing, Heiner, Aleksandrova, Krasimira, Trichopoulou, Antonia, Lagiou, Pagona, Klinaki, Eleni, Masala, Giovanna, Grioni, Sara, Santucci De Magistris, Maria, Tumino, Rosario, Ricceri, Fulvio, Peeters, Petra H M, Lund, Eiliv, Skeie, Guri, Weiderpass, Elisabete, Quirõs, J. Ramõn, Agudo, Antonio, Sánchez, María José, Dorronsoro, Miren, Navarro, Carmen, Ardanaz, Eva, Ohlsson, Bodil, Jirström, Karin, Van Guelpen, Bethany, Wennberg, Maria, Khaw, Kay Tee, Wareham, Nick, Key, Timothy J., Romieu, Isabelle, Huybrechts, Inge, Cross, Amanda J., Murphy, Neil, Riboli, Elio, and Bueno-De-Mesquita, H.
Published: 2015

412. Reproductive factors and risk of mortality in the European Prospective Investigation into Cancer and Nutrition; a cohort study

Author: MS MDL 1, Cancer, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Merritt, Melissa A., Riboli, Elio, Murphy, Neil, Kadi, Mai, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Dossus, Laure, Dartois, Laureen, Clavel-Chapelon, Françoise, Fortner, Renée T., Katzke, Verena A., Boeing, Heiner, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Palli, Domenico, Sieri, Sabina, Tumino, Rosario, Sacerdote, Carlotta, Panico, Salvatore, Bueno-de-Mesquita, H. Bas, Peeters, Petra H., Lund, Eiliv, Nakamura, Aurelie, Weiderpass, Elisabete, Quirós, J. Ramón, Agudo, Antonio, Molina-Montes, Esther, Larrañaga, Nerea, Dorronsoro, Miren, Cirera, Lluís, Barricarte, Aurelio, Olsson, Åsa, Butt, Salma, Idahl, Annika, Lundin, Eva, Wareham, Nicholas J., Key, Timothy J., Brennan, Paul, Ferrari, Pietro, Wark, Petra A., Norat, Teresa, Cross, Amanda J., Gunter, Marc J., MS MDL 1, Cancer, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Merritt, Melissa A., Riboli, Elio, Murphy, Neil, Kadi, Mai, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Dossus, Laure, Dartois, Laureen, Clavel-Chapelon, Françoise, Fortner, Renée T., Katzke, Verena A., Boeing, Heiner, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Palli, Domenico, Sieri, Sabina, Tumino, Rosario, Sacerdote, Carlotta, Panico, Salvatore, Bueno-de-Mesquita, H. Bas, Peeters, Petra H., Lund, Eiliv, Nakamura, Aurelie, Weiderpass, Elisabete, Quirós, J. Ramón, Agudo, Antonio, Molina-Montes, Esther, Larrañaga, Nerea, Dorronsoro, Miren, Cirera, Lluís, Barricarte, Aurelio, Olsson, Åsa, Butt, Salma, Idahl, Annika, Lundin, Eva, Wareham, Nicholas J., Key, Timothy J., Brennan, Paul, Ferrari, Pietro, Wark, Petra A., Norat, Teresa, Cross, Amanda J., and Gunter, Marc J.
Published: 2015

413. Plasma fetuin-A concentration, genetic variation in the AHSG gene and risk of colorectal cancer

Author: MS MDL 1, Cancer, MS MDL Oncologie, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Nimptsch, Katharina, Aleksandrova, Krasimira, Boeing, Heiner, Janke, Jürgen, Lee, Young Ae, Jenab, Mazda, Kong, So Yeon, Tsilidis, Konstantinos K., Weiderpass, Elisabete, Bueno-De-Mesquita, H. Bas, Siersema, Peter D., Jansen, Eugène H J M, Trichopoulou, Antonia, Tjønneland, Anne, Olsen, Anja, Wu, Chunsen, Overvad, Kim, Boutron-Ruault, Marie Christine, Racine, Antoine, Freisling, Heinz, Katzke, Verena, Kaaks, Rudolf, Lagiou, Pagona, Trichopoulos, Dimitrios, Severi, Gianluca, Naccarati, Alessio, Mattiello, Amalia, Palli, Domenico, Grioni, Sara, Tumino, Rosario, Peeters, Petra H., Ljuslinder, Ingrid, Nyström, Hanna, Brändstedt, Jenny, Sánchez, María José, Gurrea, Aurelio Barricarte, Bonet, Catalina Bonet, Chirlaque, María Dolores, Dorronsoro, Miren, Quirõs, José Ramõn, Travis, Ruth C., Khaw, Kay Tee, Wareham, Nick, Riboli, Elio, Gunter, Marc J., Pischon, Tobias, MS MDL 1, Cancer, MS MDL Oncologie, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Nimptsch, Katharina, Aleksandrova, Krasimira, Boeing, Heiner, Janke, Jürgen, Lee, Young Ae, Jenab, Mazda, Kong, So Yeon, Tsilidis, Konstantinos K., Weiderpass, Elisabete, Bueno-De-Mesquita, H. Bas, Siersema, Peter D., Jansen, Eugène H J M, Trichopoulou, Antonia, Tjønneland, Anne, Olsen, Anja, Wu, Chunsen, Overvad, Kim, Boutron-Ruault, Marie Christine, Racine, Antoine, Freisling, Heinz, Katzke, Verena, Kaaks, Rudolf, Lagiou, Pagona, Trichopoulos, Dimitrios, Severi, Gianluca, Naccarati, Alessio, Mattiello, Amalia, Palli, Domenico, Grioni, Sara, Tumino, Rosario, Peeters, Petra H., Ljuslinder, Ingrid, Nyström, Hanna, Brändstedt, Jenny, Sánchez, María José, Gurrea, Aurelio Barricarte, Bonet, Catalina Bonet, Chirlaque, María Dolores, Dorronsoro, Miren, Quirõs, José Ramõn, Travis, Ruth C., Khaw, Kay Tee, Wareham, Nick, Riboli, Elio, Gunter, Marc J., and Pischon, Tobias
Published: 2015

414. Body iron status and gastric cancer risk in the EURGAST study

Author: MS MDL 1, Cancer, MS MDL Oncologie, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Fonseca-Nunes, Ana, Agudo, Antonio, Aranda, Núria, Arija, Victoria, Cross, Amanda J., Molina, Esther, Sanchez, Maria Jose, Bueno-De-Mesquita, H. B., Siersema, Peter, Weiderpass, Elisabete, Krogh, Vittorio, Mattiello, Amalia, Tumino, Rosario, Saieva, Calogero, Naccarati, Alessio, Ohlsson, Bodil, Sjöberg, Klas, Boutron-Ruault, Marie Christine, Cadeau, Claire, Fagherazzi, Guy, Boeing, Heiner, Steffen, Annika, Kühn, Tilman, Katzke, Verena, Tjønneland, Anne, Olsen, Anja, Khaw, Kay Tee, Wareham, Nick, Key, Tim, Lu, Yunxia, Riboli, Elio, Peeters, Petra H., Gavrila, Diana, Dorronsoro, Miren, Quirõs, José Ramõn, Barricarte, Aurelio, Jenab, Mazda, Zamora-Ros, Raúl, Freisling, Heinz, Trichopoulou, Antonia, Lagiou, Pagona, Bamia, Christina, Jakszyn, Paula, MS MDL 1, Cancer, MS MDL Oncologie, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Fonseca-Nunes, Ana, Agudo, Antonio, Aranda, Núria, Arija, Victoria, Cross, Amanda J., Molina, Esther, Sanchez, Maria Jose, Bueno-De-Mesquita, H. B., Siersema, Peter, Weiderpass, Elisabete, Krogh, Vittorio, Mattiello, Amalia, Tumino, Rosario, Saieva, Calogero, Naccarati, Alessio, Ohlsson, Bodil, Sjöberg, Klas, Boutron-Ruault, Marie Christine, Cadeau, Claire, Fagherazzi, Guy, Boeing, Heiner, Steffen, Annika, Kühn, Tilman, Katzke, Verena, Tjønneland, Anne, Olsen, Anja, Khaw, Kay Tee, Wareham, Nick, Key, Tim, Lu, Yunxia, Riboli, Elio, Peeters, Petra H., Gavrila, Diana, Dorronsoro, Miren, Quirõs, José Ramõn, Barricarte, Aurelio, Jenab, Mazda, Zamora-Ros, Raúl, Freisling, Heinz, Trichopoulou, Antonia, Lagiou, Pagona, Bamia, Christina, and Jakszyn, Paula
Published: 2015

415. Dietary fat, fat subtypes and hepatocellular carcinoma in a large European cohort

Author: MS MDL 1, Cancer, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Duarte-Salles, Talita, Fedirko, Veronika, Stepien, Magdalena, Aleksandrova, Krasimira, Bamia, Christina, Lagiou, Pagona, Laursen, Anne Sofie Dam, Hansen, Louise, Overvad, Kim, Tjønneland, Anne, Boutron-Ruault, Marie Christine, Fagherazzi, Guy, His, Mathilde, Boeing, Heiner, Katzke, Verena, Kühn, Tilman, Trichopoulou, Antonia, Valanou, Elissavet, Kritikou, Maria, Masala, Giovanna, Panico, Salvatore, Sieri, Sabina, Ricceri, Fulvio, Tumino, Rosario, Bueno-De-Mesquita, H. B., Peeters, Petra H., Skeie, Guri, Weiderpass, Elisabete, Ardanaz, Eva, Bonet, Catalina, Chirlaque, Maria Dolores, Dorronsoro, Miren, Quirõs, J. Ramõn, Johansson, Ingegerd, Ohlsson, Bodil, Sjöberg, Klas, Wennberg, Maria, Khaw, Kay Tee, Travis, Ruth C., Wareham, Nick, Ferrari, Pietro, Freisling, Heinz, Romieu, Isabelle, Cross, Amanda J., Gunter, Marc, Lu, Yunxia, Jenab, Mazda, MS MDL 1, Cancer, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Duarte-Salles, Talita, Fedirko, Veronika, Stepien, Magdalena, Aleksandrova, Krasimira, Bamia, Christina, Lagiou, Pagona, Laursen, Anne Sofie Dam, Hansen, Louise, Overvad, Kim, Tjønneland, Anne, Boutron-Ruault, Marie Christine, Fagherazzi, Guy, His, Mathilde, Boeing, Heiner, Katzke, Verena, Kühn, Tilman, Trichopoulou, Antonia, Valanou, Elissavet, Kritikou, Maria, Masala, Giovanna, Panico, Salvatore, Sieri, Sabina, Ricceri, Fulvio, Tumino, Rosario, Bueno-De-Mesquita, H. B., Peeters, Petra H., Skeie, Guri, Weiderpass, Elisabete, Ardanaz, Eva, Bonet, Catalina, Chirlaque, Maria Dolores, Dorronsoro, Miren, Quirõs, J. Ramõn, Johansson, Ingegerd, Ohlsson, Bodil, Sjöberg, Klas, Wennberg, Maria, Khaw, Kay Tee, Travis, Ruth C., Wareham, Nick, Ferrari, Pietro, Freisling, Heinz, Romieu, Isabelle, Cross, Amanda J., Gunter, Marc, Lu, Yunxia, and Jenab, Mazda
Published: 2015

416. Plasma elaidic acid level as biomarker of industrial trans fatty acids and risk of weight change: Report from the EPIC study

Author: MS MDL 1, Cancer, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Chajès, Véronique, Biessy, Carine, Ferrari, Pietro, Romieu, Isabelle, Freisling, Heinz, Huybrechts, Inge, Scalbert, Augustin, Bueno De Mesquita, Bas, Romaguera, Dora, Gunter, Marc J., Vineis, Paolo, Hansen, Camilla Plambeck, Jakobsen, Marianne Uhre, Clavel-Chapelon, Franc¸oise, Fagherazzi, Guy, Boutron-Ruault, Marie Christine, Katzke, Verana, Neamat-Allah, Jasmine, Boeing, Heiner, Bachlechner, Ursula, Trichopoulou, Antonia, Naska, Androniki, Orfanos, Philippos, Pala, Valeria, Masala, Giovanna, Mattiello, Amalia, Skeie, Guri, Weiderpass, Elisabete, Agudo, Antonio, Huerta, Jose Maria, Ardanaz, Eva, Sánchez, Maria Jose, Dorronsoro, Miren, Quirós, Jose Ramon, Johansson, Ingegerd, Winkvist, Anna, Sonested, Emily, Key, Tim, Khaw, Kay Tee, Wareham, Nicolas J., Peeters, Petra H M, Slimani, Nadia, MS MDL 1, Cancer, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Chajès, Véronique, Biessy, Carine, Ferrari, Pietro, Romieu, Isabelle, Freisling, Heinz, Huybrechts, Inge, Scalbert, Augustin, Bueno De Mesquita, Bas, Romaguera, Dora, Gunter, Marc J., Vineis, Paolo, Hansen, Camilla Plambeck, Jakobsen, Marianne Uhre, Clavel-Chapelon, Franc¸oise, Fagherazzi, Guy, Boutron-Ruault, Marie Christine, Katzke, Verana, Neamat-Allah, Jasmine, Boeing, Heiner, Bachlechner, Ursula, Trichopoulou, Antonia, Naska, Androniki, Orfanos, Philippos, Pala, Valeria, Masala, Giovanna, Mattiello, Amalia, Skeie, Guri, Weiderpass, Elisabete, Agudo, Antonio, Huerta, Jose Maria, Ardanaz, Eva, Sánchez, Maria Jose, Dorronsoro, Miren, Quirós, Jose Ramon, Johansson, Ingegerd, Winkvist, Anna, Sonested, Emily, Key, Tim, Khaw, Kay Tee, Wareham, Nicolas J., Peeters, Petra H M, and Slimani, Nadia
Published: 2015

417. Selenium status is associated with colorectal cancer risk in the European prospective investigation of cancer and nutrition cohort

Author: Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Cancer, Hughes, David J., Fedirko, Veronika, Jenab, Mazda, Schomburg, Lutz, Meplan, Catherine, Freisling, Heinz, Bueno-de-Mesquita, H. B(as), Hybsier, Sandra, Becker, Niels-Peter, Czuban, Magdalena, Tjonneland, Anne, Outzen, Malene, Boutron-Ruault, Marie-Christine, Racine, Antoine, Bastide, Nadia, Kuehn, Tilman, Kaaks, Rudolf, Trichopoulos, Dimitrios, Trichopoulou, Antonia, Lagiou, Pagona, Panico, Salvatore, Peeters, Petra H., Weiderpass, Elisabete, Skeie, Guri, Dagrun, Engeset, Chirlaque, Maria-Dolores, Sanchez, Maria-Jose, Ardanaz, Eva, Ljuslinder, Ingrid, Wennberg, Maria, Bradbury, Kathryn E., Vineis, Paolo, Naccarati, Alessio, Palli, Domenico, Boeing, Heiner, Overvad, Kim, Dorronsoro, Miren, Jakszyn, Paula, Cross, Amanda J., Quiros, Jose Ramon, Stepien, Magdalena, Kong, So Yeon, Duarte-Salles, Talita, Riboli, Elio, Hesketh, John E., Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Cancer, Hughes, David J., Fedirko, Veronika, Jenab, Mazda, Schomburg, Lutz, Meplan, Catherine, Freisling, Heinz, Bueno-de-Mesquita, H. B(as), Hybsier, Sandra, Becker, Niels-Peter, Czuban, Magdalena, Tjonneland, Anne, Outzen, Malene, Boutron-Ruault, Marie-Christine, Racine, Antoine, Bastide, Nadia, Kuehn, Tilman, Kaaks, Rudolf, Trichopoulos, Dimitrios, Trichopoulou, Antonia, Lagiou, Pagona, Panico, Salvatore, Peeters, Petra H., Weiderpass, Elisabete, Skeie, Guri, Dagrun, Engeset, Chirlaque, Maria-Dolores, Sanchez, Maria-Jose, Ardanaz, Eva, Ljuslinder, Ingrid, Wennberg, Maria, Bradbury, Kathryn E., Vineis, Paolo, Naccarati, Alessio, Palli, Domenico, Boeing, Heiner, Overvad, Kim, Dorronsoro, Miren, Jakszyn, Paula, Cross, Amanda J., Quiros, Jose Ramon, Stepien, Magdalena, Kong, So Yeon, Duarte-Salles, Talita, Riboli, Elio, and Hesketh, John E.
Published: 2015

418. Association of CRP genetic variants with blood concentrations of C-reactive protein and colorectal cancer risk

Author: Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Cancer, Nimptsch, Katharina, Aleksandrova, Krasimira, Boeing, Heiner, Janke, Juergen, Lee, Young-Ae, Jenab, Mazda, Bueno-de-Mesquita, H. B(as), Jansen, Eugene H. J. M., Tsilidis, Konstantinos K., Trichopoulou, Antonia, Weiderpass, Elisabete, Wu, Chunsen, Overvad, Kim, Tjonneland, Anne, Boutron-Ruault, Marie-Christine, Dossus, Laure, Racine, Antoine, Kaaks, Rudolf, Canzian, Federico, Lagiou, Pagona, Trichopoulos, Dimitrios, Palli, Domenico, Agnoli, Claudia, Tumino, Rosario, Vineis, Paolo, Panico, Salvatore, Johansson, Anders, Van Guelpen, Bethany, Khaw, Kay-Tee, Wareham, Nick, Peeters, Petra H., Ramon Quiros, J., Vencesla Garcia, Adoracion, Molina-Montes, Esther, Dorronsoro, Miren, Chirlaque, Maria-Dolores, Barricarte Gurrea, Aurelio, Key, Timothy J., Duarte-Salles, Talita, Stepien, Magdalena, Gunter, Marc J., Riboli, Elio, Pischon, Tobias, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Cancer, Nimptsch, Katharina, Aleksandrova, Krasimira, Boeing, Heiner, Janke, Juergen, Lee, Young-Ae, Jenab, Mazda, Bueno-de-Mesquita, H. B(as), Jansen, Eugene H. J. M., Tsilidis, Konstantinos K., Trichopoulou, Antonia, Weiderpass, Elisabete, Wu, Chunsen, Overvad, Kim, Tjonneland, Anne, Boutron-Ruault, Marie-Christine, Dossus, Laure, Racine, Antoine, Kaaks, Rudolf, Canzian, Federico, Lagiou, Pagona, Trichopoulos, Dimitrios, Palli, Domenico, Agnoli, Claudia, Tumino, Rosario, Vineis, Paolo, Panico, Salvatore, Johansson, Anders, Van Guelpen, Bethany, Khaw, Kay-Tee, Wareham, Nick, Peeters, Petra H., Ramon Quiros, J., Vencesla Garcia, Adoracion, Molina-Montes, Esther, Dorronsoro, Miren, Chirlaque, Maria-Dolores, Barricarte Gurrea, Aurelio, Key, Timothy J., Duarte-Salles, Talita, Stepien, Magdalena, Gunter, Marc J., Riboli, Elio, and Pischon, Tobias
Published: 2015

419. Meat and fish consumption and the risk of renal cell carcinoma in the European prospective investigation into cancer and nutrition

Author: MS MDL 1, Cancer, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Rohrmann, Sabine, Linseisen, Jakob, Overvad, Kim, Wurtz, Anne Mette Lund, Roswall, Nina, Tjonneland, Anne, Boutron-Ruault, Marie-Christine, Racine, Antoine, Bastide, Nadia, Palli, Domenico, Agnoli, Claudia, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, Weikert, Steffen, Steffen, Annika, Kuehn, Tilman, Li, Kuanrong, Khaw, Kay-Tee, Wareham, Nicholas J., Bradbury, Kathryn E., Peppa, Eleni, Trichopoulou, Antonia, Trichopoulos, Dimitrios, Bueno-de-Mesquita, H. Bas, Peeters, Petra H. M., Hjartaker, Anette, Skeie, Guri, Weiderpass, Elisabete, Jakszyn, Paula, Dorronsoro, Miren, Barricarte, Aurelio, Santiuste de Pablos, Carmen, Molina-Montes, Esther, Alonso de la Torre, Ramon, Ericson, Ulrika, Sonestedt, Emily, Johansson, Mattias, Ljungberg, Borje, Freisling, Heinz, Romieu, Isabelle, Cross, Amanda J., Vergnaud, Anne-Claire, Riboli, Elio, Boeing, Heiner, MS MDL 1, Cancer, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Rohrmann, Sabine, Linseisen, Jakob, Overvad, Kim, Wurtz, Anne Mette Lund, Roswall, Nina, Tjonneland, Anne, Boutron-Ruault, Marie-Christine, Racine, Antoine, Bastide, Nadia, Palli, Domenico, Agnoli, Claudia, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, Weikert, Steffen, Steffen, Annika, Kuehn, Tilman, Li, Kuanrong, Khaw, Kay-Tee, Wareham, Nicholas J., Bradbury, Kathryn E., Peppa, Eleni, Trichopoulou, Antonia, Trichopoulos, Dimitrios, Bueno-de-Mesquita, H. Bas, Peeters, Petra H. M., Hjartaker, Anette, Skeie, Guri, Weiderpass, Elisabete, Jakszyn, Paula, Dorronsoro, Miren, Barricarte, Aurelio, Santiuste de Pablos, Carmen, Molina-Montes, Esther, Alonso de la Torre, Ramon, Ericson, Ulrika, Sonestedt, Emily, Johansson, Mattias, Ljungberg, Borje, Freisling, Heinz, Romieu, Isabelle, Cross, Amanda J., Vergnaud, Anne-Claire, Riboli, Elio, and Boeing, Heiner
Published: 2015

420. Pre-diagnostic concordance with the WCRF/AICR guidelines and survival in European colorectal cancer patients: A cohort study

Author: Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Cancer, Epi Kanker Team A, MS MDL 1, MS MDL Oncologie, Romaguera, Dora, Ward, Heather, Wark, Petra A., Vergnaud, Anne Claire, Peeters, Petra H., van Gils, Carla H., Ferrari, Pietro, Fedirko, Veronika, Jenab, Mazda, Boutron-Ruault, Marie Christine, Dossus, Laure, Dartois, Laureen, Hansen, Camilla Plambeck, Dahm, Christina Catherine, Buckland, Genevieve, Sánchez, María José, Dorronsoro, Miren, Navarro, Carmen, Barricarte, Aurelio, Key, Timothy J., Trichopoulou, Antonia, Tsironis, Christos, Lagiou, Pagona, Masala, Giovanna, Pala, Valeria, Tumino, Rosario, Vineis, Paolo, Panico, Salvatore, Bueno-de-Mesquita, H. Bas, Siersema, PD, Ohlsson, Bodil, Jirström, Karin, Wennberg, Maria, Nilsson, Lena M., Weiderpass, Elisabete, Kühn, Tilman, Katzke, Verena, Khaw, Kay Tee, Wareham, Nick J., Tjønneland, Anne, Boeing, Heiner, Quirós, José R., Gunter, Marc J., Riboli, Elio, Norat, Teresa, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Cancer, Epi Kanker Team A, MS MDL 1, MS MDL Oncologie, Romaguera, Dora, Ward, Heather, Wark, Petra A., Vergnaud, Anne Claire, Peeters, Petra H., van Gils, Carla H., Ferrari, Pietro, Fedirko, Veronika, Jenab, Mazda, Boutron-Ruault, Marie Christine, Dossus, Laure, Dartois, Laureen, Hansen, Camilla Plambeck, Dahm, Christina Catherine, Buckland, Genevieve, Sánchez, María José, Dorronsoro, Miren, Navarro, Carmen, Barricarte, Aurelio, Key, Timothy J., Trichopoulou, Antonia, Tsironis, Christos, Lagiou, Pagona, Masala, Giovanna, Pala, Valeria, Tumino, Rosario, Vineis, Paolo, Panico, Salvatore, Bueno-de-Mesquita, H. Bas, Siersema, PD, Ohlsson, Bodil, Jirström, Karin, Wennberg, Maria, Nilsson, Lena M., Weiderpass, Elisabete, Kühn, Tilman, Katzke, Verena, Khaw, Kay Tee, Wareham, Nick J., Tjønneland, Anne, Boeing, Heiner, Quirós, José R., Gunter, Marc J., Riboli, Elio, and Norat, Teresa
Published: 2015

421. The association of coffee intake with liver cancer risk is mediated by biomarkers of inflammation and hepatocellular injury: data from the European Prospective Investigation into Cancer and Nutrition

Author: Aleksandrova, Krasimira, primary, Bamia, Christina, additional, Drogan, Dagmar, additional, Lagiou, Pagona, additional, Trichopoulou, Antonia, additional, Jenab, Mazda, additional, Fedirko, Veronika, additional, Romieu, Isabelle, additional, Bueno-de-Mesquita, H Bas, additional, Pischon, Tobias, additional, Tsilidis, Kostas, additional, Overvad, Kim, additional, Tjønneland, Anne, additional, Bouton-Ruault, Marie-Christine, additional, Dossus, Laure, additional, Racine, Antoine, additional, Kaaks, Rudolf, additional, Kühn, Tilman, additional, Tsironis, Christos, additional, Papatesta, Eleni-Maria, additional, Saitakis, George, additional, Palli, Domenico, additional, Panico, Salvatore, additional, Grioni, Sara, additional, Tumino, Rosario, additional, Vineis, Paolo, additional, Peeters, Petra H, additional, Weiderpass, Elisabete, additional, Lukic, Marko, additional, Braaten, Tonje, additional, Quirós, J Ramón, additional, Luján-Barroso, Leila, additional, Sánchez, María-José, additional, Chilarque, Maria-Dolores, additional, Ardanas, Eva, additional, Dorronsoro, Miren, additional, Nilsson, Lena Maria, additional, Sund, Malin, additional, Wallström, Peter, additional, Ohlsson, Bodil, additional, Bradbury, Kathryn E, additional, Khaw, Kay-Tee, additional, Wareham, Nick, additional, Stepien, Magdalena, additional, Duarte-Salles, Talita, additional, Assi, Nada, additional, Murphy, Neil, additional, Gunter, Marc J, additional, Riboli, Elio, additional, Boeing, Heiner, additional, and Trichopoulos, Dimitrios, additional
Published: 2015
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422. The Association between Glyceraldehyde-Derived Advanced Glycation End-Products and Colorectal Cancer Risk

Author: Kong, So Yeon, primary, Takeuchi, Masayoshi, additional, Hyogo, Hideyuki, additional, McKeown-Eyssen, Gail, additional, Yamagishi, Sho-ichi, additional, Chayama, Kazuaki, additional, O'Brien, Peter J., additional, Ferrari, Pietro, additional, Overvad, Kim, additional, Olsen, Anja, additional, Tjønneland, Anne, additional, Boutron-Ruault, Marie-Christine, additional, Bastide, Nadia, additional, Carbonnel, Franck, additional, Kühn, Tilman, additional, Kaaks, Rudolf, additional, Boeing, Heiner, additional, Aleksandrova, Krasimira, additional, Trichopoulou, Antonia, additional, Lagiou, Pagona, additional, Vasilopoulou, Effie, additional, Masala, Giovanna, additional, Pala, Valeria, additional, Santucci De Magistris, Maria, additional, Tumino, Rosario, additional, Naccarati, Alessio, additional, Bueno-de-Mesquita, H.B., additional, Peeters, Petra H., additional, Weiderpass, Elisabete, additional, Quirós, J. Ramón, additional, Jakszyn, Paula, additional, Sánchez, María-José, additional, Dorronsoro, Miren, additional, Gavrila, Diana, additional, Ardanaz, Eva, additional, Rutegård, Martin, additional, Nyström, Hanna, additional, Wareham, Nicholas J., additional, Khaw, Kay-Tee, additional, Bradbury, Kathryn E., additional, Romieu, Isabelle, additional, Freisling, Heinz, additional, Stavropoulou, Faidra, additional, Gunter, Marc J., additional, Cross, Amanda J., additional, Riboli, Elio, additional, Jenab, Mazda, additional, and Bruce, W. Robert, additional
Published: 2015
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423. Intake of Coffee, Decaffeinated Coffee, or Tea Does Not Affect Risk for Pancreatic Cancer:Results from the EPIC study

Author: Bhoo-Pathy, Nirmala, Uiterwaal, Cuno S P M, Dik, Vincent K, Jeurnink, Suzanne M, Bech, Bodil H, Overvad, Kim, Halkjær, Jytte, Tjønneland, Anne, Boutron-Ruault, Marie-Christine, Fagherazzi, Guy, Racine, Antoine, Katzke, Verena A, Li, Kuanrong, Boeing, Heiner, Floegel, Anna, Androulidaki, Anna, Bamia, Christina, Trichopoulou, Antonia, Masala, Giovanna, Panico, Salvatore, Crosignani, Paolo, Tumino, Rosario, Vineis, Paolo, Peeters, Petra H M, Gavrilyuk, Oxana, Skeie, Guri, Weiderpass, Elisabete, Duell, Eric J, Arguelles, Marcial, Molina-Montes, Esther, Navarro, Carmen, Ardanaz, Eva, Dorronsoro, Miren, Lindkvist, Björn, Wallström, Peter, Sund, Malin, Ye, Weimin, Khaw, Kay-Tee, Wareham, Nick, Key, Timothy J, Travis, Ruth C, Duarte-Salles, Talita, Freisling, Heinz, Licaj, Idlir, Gallo, Valentina, Michaud, Dominique S, Riboli, Elio, and Bueno-de-Mesquita, H Bas
Abstract: BACKGROUND & AIMS: Few modifiable risk factors have been implicated in the etiology of pancreatic cancer. There is little evidence for the effects of caffeinated coffee, decaffeinated coffee, or tea intake on risk of pancreatic cancer. We investigated the association of total coffee, caffeinated coffee, decaffeinated coffee, and tea consumption with risk of pancreatic cancer. METHODS: This study was conducted within the European Prospective Investigation into Nutrition and Cancer (EPIC) cohort, comprising male and female participants from 10 European countries. Between 1992 and 2000, 477,312 participants without cancer completed a dietary questionnaire, and were followed to determine pancreatic cancer incidence. Coffee and tea intakes were calibrated with a 24-hour dietary recall. Adjusted hazard ratios (HRs) were computed using multivariable Cox regression. RESULTS: During a mean follow-up of 11.6 y, 865 first incidences of pancreatic cancers were reported. When divided into fourths, neither total intake of coffee (HR,1.03; 95% confidence interval [CI], 0.83-1.27; high vs low intake), decaffeinated coffee (HR, 1.12; 95% CI, 0.76-1.63; high vs low), nor tea were associated with risk of pancreatic cancer (HR, 1.22, 95% CI, 0.95-1.56; high vs low). Moderately low intake of caffeinated coffee was associated with an increased risk of pancreatic cancer (HR, 1.33; 95% CI, 1.02-1.74), compared to low intake. However, no graded dose response was observed, and the association attenuated following restriction to histologically confirmed pancreatic cancers. CONCLUSION: Based on analysis of data from the EPIC cohort, total coffee, decaffeinated coffee, and tea consumption are not related to the risk of pancreatic cancer.
Published: 2013

424. Abdominal obesity, weight gain during adulthood and risk of liver and biliary tract cancer in a European cohort

Author: Schlesinger, Sabrina Aleksandrova, Krasimira Pischon, Tobias and Fedirko, Veronika Jenab, Mazda Trepo, Elisabeth Boffetta, Paolo Dahm, Christina C. Overvad, Kim Tjonneland, Anne and Halkjaer, Jytte Fagherazzi, Guy Boutron-Ruault, Marie-Christine and Carbonnel, Franck Kaaks, Rudolf Lukanova, Annekatrin and Boeing, Heiner Trichopoulou, Antonia Bamia, Christina and Lagiou, Pagona Palli, Domenico Grioni, Sara Panico, Salvatore Tumino, Rosario Vineis, Paolo Bueno-de-Mesquita, H. B. van den Berg, Saskia Peeters, Petra H. M. Braaten, Tonje Weiderpass, Elisabete Quiros, J. Ramon Travier, Noemie and Sanchez, Maria-Jose Navarro, Carmen Barricarte, Aurelio and Dorronsoro, Miren Lindkvist, Bjorn Regner, Sara Werner, Marten Sund, Malin Khaw, Kay-Tee Wareham, Nicholas and Travis, Ruth C. Norat, Teresa Wark, Petra A. Riboli, Elio and Nothlings, Ute
Abstract: General obesity has been positively associated with risk of liver and probably with biliary tract cancer, but little is known about abdominal obesity or weight gain during adulthood. We used multivariable Cox proportional hazard models to investigate associations between weight, body mass index, waist and hip circumference, waist-to-hip and waist-to-height ratio (WHtR), weight change during adulthood and risk of hepatocellular carcinoma (HCC), intrahepatic (IBDC) and extrahepatic bile duct system cancer [EBDSC including gallbladder cancer (GBC)] among 359,525 men and women in the European Prospective Investigation into Cancer and Nutrition study. Hepatitis B and C virus status was measured in a nested casecontrol subset. During a mean follow-up of 8.6 years, 177 cases of HCC, 58 cases of IBDC and 210 cases of EBDSC, including 76 cases of GBC, occurred. All anthropometric measures were positively associated with risk of HCC and GBC. WHtR showed the strongest association with HCC [relative risk (RR) comparing extreme tertiles 3.51, 95% confidence interval (95% CI): 2.095.87; ptrend < 0.0001] and with GBC (RR: 1.56, 95% CI: 1.122.16 for an increment of one unit in WHtR). Weight gain during adulthood was also positively associated with HCC when comparing extreme tertiles (RR: 2.48, 95% CI: 1.494.13
Published: 2013

425. Lifestyle, dietary factors, and antibody levels to oral bacteria in cancer-free participants of a European cohort study

Author: Michaud, Dominique S. Izard, Jacques Rubin, Zachary and Johansson, Ingegerd Weiderpass, Elisabete Tjonneland, Anne and Olsen, Anja Overvad, Kim Boutron-Ruault, Marie Christine and Clavel-Chapelon, Francoise Dossus, Laure Kaaks, Rudolf and Katzke, Verena A. Boeing, Heiner Foerster, Jana and Trichopoulou, Antonia Naska, Androniki Ziara, Giana Vineis, Paolo Grioni, Sara Palli, Domenico Tumino, Rosario and Mattiello, Amalia Peeters, Petra H. M. Siersema, Peter D. and Barricarte, Aurelio Huerta, Jose-Maria Molina-Montes, Esther and Dorronsoro, Miren Ramon Quiros, J. Duell, Eric J. Ohlsson, Bodil Jeppsson, Bengt Johansson, Anders Lif, Pernilla and Khaw, Kay-Tee Wareham, Nick Travis, Ruth C. Key, Tim J. and Freisling, Heinz Duarte-Salles, Talita Stepien, Magdalena and Riboli, Elio Bueno-de-Mesquita, H. Bas
Abstract: Increasing evidence suggests that oral microbiota play a pivotal role in chronic diseases, in addition to the well-established role in periodontal disease. Moreover, recent studies suggest that oral bacteria may also be involved in carcinogenesis; periodontal disease has been linked to several cancers. In this study, we examined whether lifestyle factors have an impact on antibody levels to oral bacteria. Data on demographic characteristics, lifestyle factors, and medical conditions were obtained at the time of blood sample collection. For the current analysis, we measured antibody levels to 25 oral bacteria in 395 cancer-free individuals using an immunoblot array. Combined total immunoglobin G (IgG) levels were obtained by summing concentrations for all oral bacteria measured. IgG antibody levels were substantially lower among current and former smokers (1,697 and 1,677 ng/mL, respectively) than never smokers (1,960 ng/mL; p trend = 0.01), but did not vary by other factors, including body mass index, diabetes, physical activity, or by dietary factors, after adjusting for age, sex, education, country, and smoking status. The highest levels of total IgG were found among individuals with low education (2,419 ng/mL). Our findings on smoking are consistent with previous studies and support the notion that smokers have a compromised humoral immune response. Moreover, other major factors known to be associated with inflammatory markers, including obesity, were not associated with antibody levels to a large number of oral bacteria.
Published: 2013

426. Dietary flavonoid, lignan and antioxidant capacity and risk of hepatocellular carcinoma in the European prospective investigation into cancer and nutrition study

Author: Zamora-Ros, Raul Fedirko, Veronika Trichopoulou, Antonia and Gonzalez, Carlos A. Bamia, Christina Trepo, Elisabeth and Noethlings, Ute Duarte-Salles, Talita Serafini, Mauro and Bredsdorff, Lea Overvad, Kim Tjonneland, Anne Halkjaer, Jytte Fagherazzi, Guy Perquier, Florence Boutron-Ruault, Marie-Christine Katzke, Verena Lukanova, Annekatrin Floegel, Anna Boeing, Heiner Lagiou, Pagona Trichopoulos, Dimitrios and Saieva, Calogero Agnoli, Claudia Mattiello, Amalia and Tumino, Rosario Sacerdote, Carlotta Bueno-de-Mesquita, H. Bas and Peeters, Petra H. M. Weiderpass, Elisabete Engeset, Dagrun and Skeie, Guri Argueelles, Marcial Vicente Molina-Montes, Esther Dorronsoro, Miren Tormo, Maria Jose Ardanaz, Eva and Ericson, Ulrika Sonestedt, Emily Sund, Malin Landberg, Rikard Khaw, Kay-Tee Wareham, Nicholas J. Crowe, Francesca L. Riboli, Elio Jenab, Mazda
Abstract: Limited epidemiological evidence suggests a protective role for plant foods rich in flavonoids and antioxidants in hepatocellular cancer (HCC) etiology. Our aim was to prospectively investigate the association between dietary intake of flavonoids, lignans and nonenzymatic antioxidant capacity (NEAC) and HCC risk. Data from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort including 477,206 subjects (29.8% male) recruited from ten Western European countries, was analyzed. Flavonoid, lignan and NEAC intakes were calculated using a compilation of existing food composition databases linked to dietary information from validated dietary questionnaires. Dietary NEAC was based on ferric reducing antioxidant capacity (FRAP) and total radical-trapping antioxidant parameter (TRAP). Hepatitis B/C status was measured in a nested case-control subset. During a mean follow-up of 11-years, 191 incident HCC cases (66.5% men) were identified. Using Cox regression, multivariable adjusted models showed a borderline nonsignificant association of HCC with total flavonoid intake (highest versus lowest tertile, HR=0.65, 95% CI: 0.40-1.04; p(trend)=0.065), but not with lignans. Among flavonoid subclasses, flavanols were inversely associated with HCC risk (HR=0.62, 95% CI: 0.39-0.99; p(trend)=0.06). Dietary NEAC was inversely associated with HCC (FRAP: HR 0.50, 95% CI: 0.31-0.81; p(trend)=0.001; TRAP: HR 0.49, 95% CI: 0.31-0.79; p(trend)=0.002), but statistical significance was lost after exclusion of the first 2 years of follow-up. This study suggests that higher intake of dietary flavanols and antioxidants may be associated with a reduced HCC risk. What’s new? Coffee, tea, fruits and vegetables, and certain other foods may protect against hepatocellular carcinoma (HCC), thanks to their antioxidant ingredients. This study lends fresh support to that idea, revealing specifically that dietary flavanols, which possess antioxidant activity, could play a favourable role in HCC prevention. Dietary antioxidant capacity from coffee intake in particular was found to be inversely associated with HCC risk, though statistical significance was lost after exclusion of the first two years of follow-up. Assessment of the bioavailability of flavonoids and other antioxidants is needed to confirm links between antioxidant intake and HCC risk.
Published: 2013

427. Menstrual and reproductive factors in women, genetic variation in CYP17A1, and pancreatic cancer risk in the European prospective investigation into cancer and nutrition (EPIC) cohort

Author: Duell, Eric J. Travier, Noemie Lujan-Barroso, Leila Dossus, Laure Boutron-Ruault, Marie-Christine Clavel-Chapelon, Francoise and Tumino, Rosario Masala, Giovanna Krogh, Vittorio Panico, Salvatore Ricceri, Fulvio Luisa Redondo, Maria Dorronsoro, Miren Molina-Montes, Esther Huerta, Jose M. Barricarte, Aurelio Khaw, Kay-Tee Wareham, Nick J. Allen, Naomi E. and Travis, Ruth Siersema, Peter D. Peeters, Petra H. M. and Trichopoulou, Antonia Fragogeorgi, Eirini Oikonomou, Eleni and Boeing, Heiner Schuetze, Madlen Canzian, Federico Lukanova, Annekatrin Tjonneland, Anne Roswall, Nina Overvad, Kim and Weiderpass, Elisabete Gram, Inger Torhild Lund, Eiliv and Lindkvist, Bjorn Johansen, Dorthe Ye, Weimin Sund, Malin and Fedirko, Veronika Jenab, Mazda Michaud, Dominique S. Riboli, Elio Bueno-de-Mesquita, H. Bas
Abstract: Menstrual and reproductive factors and exogenous hormone use have been investigated as pancreatic cancer risk factors in case-control and cohort studies, but results have been inconsistent. We conducted a prospective examination of menstrual and reproductive factors, exogenous hormone use and pancreatic cancer risk (based on 304 cases) in 328,610 women from the EPIC cohort. Then, in a case-control study nested within the EPIC cohort, we examined 12 single nucleotide polymorphisms (SNPs) in CYP17A1 (an essential gene in sex steroid metabolism) for association with pancreatic cancer in women and men (324 cases and 353 controls). Of all factors analyzed, only younger age at menarche (
Published: 2013

428. Anthropometric characteristics and risk of lymphoid and myeloid leukemia in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author: Hosnijeh, Fatemeh Saberi Romieu, Isabelle Gallo, Valentina and Riboli, Elio Tjonneland, Anne Halkjaer, Jytte Fagherazzi, Guy Clavel-Chapelon, Francoise Dossus, Laure Lukanova, Annie and Kaaks, Rudolf Trichopoulou, Antonia Lagiou, Pagona and Katsoulis, Michael Panico, Salvatore Tagliabue, Giovanna and Bonet, Catalina Dorronsoro, Miren Maria Huerta, Jose and Ardanaz, Eva Sanchez, Maria-Jose Johansen, Dorthe Borgquist, Signe Peeters, Petra Bueno-de-Mesquita, H. Bas Ros, Martine M. Travis, Ruth C. Key, Timothy J. Vineis, Paolo and Vermeulen, Roel
Subjects: hemic and lymphatic diseases
Abstract: Overweight and obesity have been suggested as a risk factor for leukemia. Impaired immune function associated with obesity, increased insulin-like growth factor-I activity and stimulating effects of leptin suggest a possible biological link between anthropometric measures and leukemia. However, evidence from epidemiological studies has been inconsistent. We examined the potential association between prospective measurements of body size and risk of leukemia among participants of the European Prospective Investigation into Cancer and Nutrition (EPIC). During follow-up (mean = 11.52 years, standard deviation = 2.63), 671 leukemia (lymphoid leukemia = 50.1 %, myeloid leukemia = 43.2 %) cases were identified. Anthropometric measures including weight, height, body mass index (BMI), waist circumference (WC), hip circumference, and waist-to-hip ratio (WHR) were measured. Cox proportional hazard models were used to explore the association between anthropometric measures and risk of leukemia. No associations were observed between anthropometric measures and total leukemia, and lymphoid leukemia. Risk of myeloid leukemia significantly increased for higher categories of BMI and WC among women. Analyses by subtype of myeloid leukemia showed an increased risk of acute myeloid leukemia (AML) for higher categories of WHR among women. This association seemed to be reversed for chronic myeloid leukemia. No association between anthropometric measures and myeloid leukemia were observed among men except an increased risk of AML with height. The study showed no associations between anthropometric measures and total leukemia, and lymphoid leukemia among men and women. A possible association between BMI as general obesity and WC as abdominal obesity and increased risk of myeloid leukemia among women were observed.
Published: 2013

429. Mediterranean diet and colorectal cancer risk: results from a European cohort

Author: Bamia, Christina Lagiou, Pagona Buckland, Genevieve Grioni, Sara Agnoli, Claudia Taylor, Aliki J. Dahm, Christina C. and Overvad, Kim Olsen, Anja Tjonneland, Anne Cottet, Vanessa and Boutron-Ruault, Marie-Christine Morois, Sophie Grote, Verena and Teucher, Birgit Boeing, Heiner Buijsse, Brian and Trichopoulos, Dimitrios Adarakis, George Tumino, Rosario and Naccarati, Alessio Panico, Salvatore Palli, Domenico and Bueno-de-Mesquita, H. Bas van Duijnhoven, Fraenzel J. B. and Peeters, Petra H. M. Engeset, Dagrun Skeie, Guri Lund, Eiliv and Sanchez, Maria-Jose Barricarte, Aurelio Huerta, Jose-Maria and Ramon Quiros, J. Dorronsoro, Miren Ljuslinder, Ingrid and Palmqvist, Richard Drake, Isabel Key, Timothy J. Khaw, Kay-Tee Wareham, Nick Romieu, Isabelle Fedirko, Veronika and Jenab, Mazda Romaguera, Dora Norat, Teresa Trichopoulou, Antonia
Abstract: The authors investigated the association of adherence to Mediterranean diet with colorectal cancer (CRC) risk in the European Prospective Investigation into Cancer and nutrition study. Adherence to Mediterranean diet was expressed through two 10-unit scales, the Modified Mediterranean diet score (MMDS) and the Centre-Specific MMDS (CSMMDS). Both scales share the same dietary components but differ in the cut-off values that were used for these components in the construction of the scales. Adjusted hazard ratios (HR) for the associations of these scales with CRC incidence were estimated. After 5,296,617 person-years of follow-up, 4,355 incident CRC cases were identified. A decreased risk of CRC, of 8 and 11 % was estimated when comparing the highest (scores 6-9) with the lowest (scores 0-3) adherence to CSMMDS and MMDS respectively. For MMDS the HR was 0.89 (95 % confidence interval (CI): 0.80, 0.99). A 2-unit increment in either Mediterranean scale was associated with a borderline statistically significant 3 to 4 % reduction in CRC risk (HR for MMDS: 0.96; 95 % CI: 0.92, 1.00). These associations were somewhat more evident, among women, were mainly manifested for colon cancer risk and their magnitude was not altered when alcohol was excluded from MMDS. These findings suggest that following a Mediterranean diet may have a modest beneficial effect on CRC risk.
Published: 2013

430. Consumption of Dairy Products and Colorectal Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author: Murphy, Neil Norat, Teresa Ferrari, Pietro Jenab, Mazda and Bueno-de-Mesquita, Bas Skeie, Guri Olsen, Anja Tjonneland, Anne Dahm, Christina C. Overvad, Kim Boutron-Ruault, Marie Christine Clavel-Chapelon, Francoise Nailler, Laura Kaaks, Rudolf Teucher, Birgit Boeing, Heiner Bergmann, Manuela M. and Trichopoulou, Antonia Lagiou, Pagona Trichopoulos, Dimitrios and Palli, Domenico Pala, Valeria Tumino, Rosario Vineis, Paolo Panico, Salvatore Peeters, Petra H. M. Dik, Vincent K. and Weiderpass, Elisabete Lund, Eiliv Quiros Garcia, Jose Ramon and Zamora-Ros, Raul Sanchez Perez, Maria Jose Dorronsoro, Miren and Navarro, Carmen Ardanaz, Eva Manjer, Jonas Almquist, Martin Johansson, Ingegerd Palmqvist, Richard Khaw, Kay-Tee and Wareham, Nick Key, Timothy J. Crowe, Francesca L. and Fedirko, Veronika Gunter, Marc J. Riboli, Elio
Abstract: Background: Prospective studies have consistently reported lower colorectal cancer risks associated with higher intakes of total dairy products, total milk and dietary calcium. However, less is known about whether the inverse associations vary for individual dairy products with differing fat contents. Materials and Methods: In the European Prospective Investigation into Cancer and Nutrition (EPIC), we investigated the associations between intakes of total milk and milk subtypes (whole-fat, semi-skimmed and skimmed), yoghurt, cheese, and dietary calcium with colorectal cancer risk amongst 477,122 men and women. Dietary questionnaires were administered at baseline. Multivariable hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models, adjusted for relevant confounding variables. Results: During the mean 11 years of follow-up, 4,513 incident cases of colorectal cancer occurred. After multivariable adjustments, total milk consumption was inversely associated with colorectal cancer risk (HR per 200 g/day 0.93, 95% CI: 0.89-0.98). Similar inverse associations were observed for whole-fat (HR per 200 g/day 0.90, 95% CI: 0.82-0.99) and skimmed milk (HR per 200 g/day 0.90, 95% CI: 0.79-1.02) in the multivariable models. Inverse associations were observed for cheese and yoghurt in the categorical models; although in the linear models, these associations were non-significant. Dietary calcium was inversely associated with colorectal cancer risk (HR per 200 mg/day 0.95, 95% CI: 0.91-0.99); this association was limited to dairy sources of calcium only (HR per 200 mg/day 0.95, 95% CI: 0.91-0.99), with no association observed for non-dairy calcium sources (HR per 200 mg/day 1.00, 95% CI: 0.81-1.24). Conclusions: Our results strengthen the evidence for a possible protective role of dairy products on colorectal cancer risk. The inverse associations we observed did not differ by the fat content of the dairy products considered.
Published: 2013

431. Occupation and risk of lymphoid and myeloid leukaemia in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author: Hosnijeh, Fatemeh Saberi Christopher, Yvette Peeters, Petra and Romieu, Isabelle Xun, Wei Riboli, Elio Raaschou-Nielsen, Ole and Tjonneland, Anne Becker, Nikolaus Nieters, Alexandra and Trichopoulou, Antonia Bamia, Christina Orfanos, Philip and Oddone, Enrico Lujan-Barroso, Leila Dorronsoro, Miren and Navarro, Carmen Barricarte, Aurelio Molina-Montes, Esther and Wareham, Nick Vineis, Paolo Vermeulen, Roel
Subjects: hemic and lymphatic diseases
Abstract: Objectives Established risk factors for leukaemia do not explain the majority of leukaemia cases. Previous studies have suggested the importance of occupation and related exposures in leukaemogenesis. We evaluated possible associations between job title and selected hazardous agents and leukaemia in the European Prospective Investigation into Cancer and Nutrition. Methods The mean follow-up time for 241 465 subjects was 11.20 years (SD 2.42 years). During the follow-up period, 477 incident cases of myeloid and lymphoid leukaemia occurred. Data on 52 occupations considered a priori to be at high risk of developing cancer were collected through standardised questionnaires. Occupational exposures were estimated by linking the reported occupations to a job exposure matrix. Cox proportional hazard models were used to explore the association between occupation and related exposures and risk of leukaemia. Results The risk of lymphoid leukaemia significantly increased for working in chemical laboratories (HR 8.35, 95% CI 1.58 to 44.24), while the risk of myeloid leukaemia increased for working in the shoe or other leather goods industry (HR 2.54, 95% CI 1.28 to 5.06). Exposure-specific analyses showed a non-significant increased risk of myeloid leukaemias for exposure to benzene (HR 1.15, 95% CI 0.75 to 1.40; HR=1.60, 95% CI 0.95 to 2.69 for the low and high exposure categories, respectively). This association was present both for acute and chronic myeloid leukaemia at high exposure levels. However, numbers were too small to reach statistical significance. Conclusions Our findings suggest a possible role of occupational exposures in the development of both lymphoid and myeloid leukaemia. Exposure to benzene seemed to be associated with both acute and chronic myeloid leukaemia.
Published: 2013

432. Development and Validation of a Risk Score Predicting Substantial Weight Gain over 5 Years in Middle-Aged European Men and Women

Author: Steffen, Annika Sorensen, Thorkild I. A. Knueppel, Sven and Travier, Noemie Sanchez, Maria-Jose Maria Huerta, Jose Ramon Quiros, J. Ardanaz, Eva Dorronsoro, Miren Teucher, Birgit and Li, Kuanrong Bueno-de-Mesquita, H. Bas van der A, Daphne and Mattiello, Amalia Palli, Domenico Tumino, Rosario Krogh, Vittorio Vineis, Paolo Trichopoulou, Antonia Orfanos, Philippos Trichopoulos, Dimitrios Hedblad, Bo Wallstrom, Peter Overvad, Kim Halkjaer, Jytte Tjonneland, Anne and Fagherazzi, Guy Dartois, Laureen Crowe, Francesca Khaw, Kay-Tee Wareham, Nick Middleton, Lefkos May, Anne M. and Peeters, Petra H. M. Boeing, Heiner
Abstract: Background: Identifying individuals at high risk of excess weight gain may help targeting prevention efforts at those at risk of various metabolic diseases associated with weight gain. Our aim was to develop a risk score to identify these individuals and validate it in an external population. Methods: We used lifestyle and nutritional data from 53 degrees 758 individuals followed for a median of 5.4 years from six centers of the European Prospective Investigation into Cancer and Nutrition (EPIC) to develop a risk score to predict substantial weight gain (SWG) for the next 5 years (derivation sample). Assuming linear weight gain, SWG was defined as gaining >= 10% of baseline weight during follow-up. Proportional hazards models were used to identify significant predictors of SWG separately by EPIC center. Regression coefficients of predictors were pooled using random-effects meta-analysis. Pooled coefficients were used to assign weights to each predictor. The risk score was calculated as a linear combination of the predictors. External validity of the score was evaluated in nine other centers of the EPIC study (validation sample). Results: Our final model included age, sex, baseline weight, level of education, baseline smoking, sports activity, alcohol use, and intake of six food groups. The model’s discriminatory ability measured by the area under a receiver operating characteristic curve was 0.64 (95% CI = 0.63-0.65) in the derivation sample and 0.57 (95% CI = 0.56-0.58) in the validation sample, with variation between centers. Positive and negative predictive values for the optimal cut-off value of >= 200 points were 9% and 96%, respectively. Conclusion: The present risk score confidently excluded a large proportion of individuals from being at any appreciable risk to develop SWG within the next 5 years. Future studies, however, may attempt to further refine the positive prediction of the score.
Published: 2013

433. Intake of Coffee, Decaffeinated Coffee, or Tea Does Not Affect Risk for Pancreatic Cancer: Results From the European Prospective Investigation into Nutrition and Cancer Study

Author: Bhoo-Pathy, Nirmala Uiterwaal, Cuno S. P. M. Dik, Vincent K. and Jeurnink, Suzanne M. Bech, Bodil H. Overvad, Kim Halkjaer, Jytte Tjonneland, Anne Boutron-Ruault, Marie-Christine and Fagherazzi, Guy Racine, Antoine Katzke, Verena A. Li, Kuanrong Boeing, Heiner Floegel, Anna Androulidaki, Anna and Bamia, Christina Trichopoulou, Antonia Masala, Giovanna and Panico, Salvatore Crosignani, Paolo Tumino, Rosario Vineis, Paolo Peeters, Petra H. M. Gavrilyuk, Oxana Skeie, Guri and Weiderpass, Elisabete Duell, Eric J. Arguelles, Marcial and Molina-Montes, Esther Navarro, Carmen Ardanaz, Eva and Dorronsoro, Miren Lindkvist, Bjorn Wallstrom, Peter Sund, Malin Ye, Weimin Khaw, Kay-Tee Wareham, Nick Key, Timothy J. Travis, Ruth C. Duarte-Salles, Talita Freisling, Heinz Licaj, Idlir Gallo, Valentina Michaud, Dominique S. and Riboli, Elio Bueno-De-Mesquita, H. Bas
Abstract: BACKGROUND & AIMS: Few modifiable risk factors have been implicated in the etiology of pancreatic cancer. There is little evidence for the effects of caffeinated coffee, decaffeinated coffee, or tea intake on risk of pancreatic cancer. We investigated the association of total coffee, caffeinated coffee, decaffeinated coffee, and tea consumption with risk of pancreatic cancer. METHODS: This study was conducted within the European Prospective Investigation into Nutrition and Cancer cohort, comprising male and female participants from 10 European countries. Between 1992 and 2000, there were 477,312 participants without cancer who completed a dietary questionnaire and were followed up to determine pancreatic cancer incidence. Coffee and tea intake was calibrated with a 24-hour dietary recall. Adjusted hazard ratios (HRs) were computed using multivariable Cox regression. RESULTS: During a mean follow-up period of 11.6 y, 865 first incidences of pancreatic cancers were reported. When divided into fourths, neither total intake of coffee (HR, 1.03; 95% confidence interval [CI], 0.83-1.27; high vs low intake), decaffeinated coffee ( HR, 1.12; 95% CI, 0.76-1.63; high vs low intake), nor tea were associated with risk of pancreatic cancer ( HR, 1.22, 95% CI, 0.95-1.56; high vs low intake). Moderately low intake of caffeinated coffee was associated with an increased risk of pancreatic cancer ( HR, 1.33; 95% CI, 1.02-1.74), compared with low intake. However, no graded dose response was observed, and the association attenuated after restriction to histologically confirmed pancreatic cancers. CONCLUSIONS: Based on an analysis of data from the European Prospective Investigation into Nutrition and Cancer cohort, total coffee, decaffeinated coffee, and tea consumption are not related to the risk of pancreatic cancer.
Published: 2013

434. Macronutrient intake and risk of urothelial cell carcinoma in the European prospective investigation into cancer and nutrition

Author: Allen, Naomi E. Appleby, Paul N. Key, Timothy J. and Bueno-de-Mesquita, H. B. Ros, Martine M. Kiemeney, Lambertus A. L. M. Tjonneland, Anne Roswall, Nina Overvad, Kim and Weikert, Steffen Boeing, Heiner Chang-Claude, Jenny Teucher, Birgit Panico, Salvatore Sacerdote, Carlotta Tumino, Rosario and Palli, Domenico Sieri, Sabina Peeters, Petra Ramon Quiros, Jose Jakszyn, Paula Molina-Montes, Esther Chirlaque, Maria-Dolores Ardanaz, Eva Dorronsoro, Miren Khaw, Kay-Tee and Wareham, Nick Ljungberg, Borje Hallmans, Goran and Ehrnstrom, Roy Ericson, Ulrika Torhild Gram, Inger Parr, Christine L. Trichopoulou, Antonia Karapetyan, Tina Dilis, Vardis Clavel-Chapelon, Francoise Boutron-Ruault, Marie-Christine Fagherrazzi, Guy Romieu, Isabelle Gunter, Marc J. Riboli, Elio
Abstract: Previous studies have suggested that dietary factors may be important in the development of bladder cancer. We examined macronutrient intake in relation to risk of urothelial cell carcinoma among 469,339 men and women in the European Prospective Investigation into Cancer and Nutrition. Associations were examined using Cox regression, stratified by sex, age at recruitment and centre and further adjusted for smoking status and duration, body mass index and total energy intake. After an average of 11.3 years of follow-up, 1,416 new cases of urothelial cell carcinoma were identified. After allowing for measurement error, a 3% increase in the consumption of energy intake from animal protein was associated with a 15% higher risk (95% confidence interval [CI]: 330%; ptrend = 0.01) and a 2% increase in energy from plant protein intake was associated with a 23% lower risk (95% CI: 367%, ptrend = 0.006). Dietary intake of fat, carbohydrate, fibre or calcium was not associated with risk. These findings suggest that animal and/or plant protein may affect the risk of urothelial cell carcinoma, and examination of these associations in other studies is needed.
Published: 2013

435. Anti-CA15.3 and Anti-CA125 Antibodies and Ovarian Cancer Risk: Results from the EPIC Cohort.

Author: Cramer, Daniel W., Fichorova, Raina N., Terry, Kathryn L., Hidemi Yamamoto, Vitonis, Allison F., Ardanaz, Eva, Aune, Dagfinn, Boeing, Heiner, Brändstedt, Jenny, Boutron-Ruault, Marie-Christine, Chirlaque, Maria-Dolores, Dorronsoro, Miren, Dossus, Laure, Duell, Eric J., Gram, Inger T., Gunter, Marc, Hansen, Louise, Idahl, Annika, Johnson, Theron, and Kay-Tee Khaw
Abstract: Background: Neoplastic and non-neoplastic events may raise levels of mucins, CA15.3, and CA125, and generate antibodies against them, but their impact on epithelial ovarian cancer (EOC) risk has not been fully defined. Methods: CA15.3, CA125, and IgG1 antibodies against them were measured in 806 women who developed EOC and 1,927 matched controls from the European Prospective Investigation of Nutrition and Cancer. Associations between epidemiologic factors and anti-mucin antibodies were evaluated using generalized linear models; EOC risks associated with anti-mucin antibodies, by themselves or in combination with respective antigens, were evaluated using conditional logistic regression. Results: In controls, lower antibodies against both mucins were associated with current smoking; and, in postmenopausal women, higher levels with longer oral contraceptive use and later-age-at and shorter-interval-since last birth. Lower anti-CA15.3 antibodies were associated with higher body mass and, in premenopausal women, more ovulatory cycles. Higher anti-CA15.3 and anti-CA125 antibodies were associated with higher risk for mucinous EOC occurring ≥ 3 years from enrollment. Long-term risk for serous EOC was reduced in women with low CA125 and high anti-CA125 antibodies relative to women with low concentrations of both. Conclusions: We found general support for the hypothesis that anti-mucin antibody levels correlate with risk factors for EOC. Antibodies alone or in combinations with their antigen may predict longer term risk of specific EOC types. [ABSTRACT FROM AUTHOR]
Published: 2018
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436. Interplay between genetic predisposition, macronutrient intake and type 2 diabetes incidence: analysis within EPIC-InterAct across eight European countries.

Author: Li, Sherly X., Imamura, Fumiaki, Schulze, Matthias B., Zheng, Jusheng, Ye, Zheng, Agudo, Antonio, Ardanaz, Eva, Aune, Dagfinn, Boeing, Heiner, Dorronsoro, Miren, Dow, Courtney, Fagherazzi, Guy, Grioni, Sara, Gunter, Marc J., Huerta, José María, Ibsen, Daniel B., Jakobsen, Marianne Uhre, Kaaks, Rudolf, Key, Timothy J., and Khaw, Kay-Tee
Abstract: Aims/hypothesis: Gene-macronutrient interactions may contribute to the development of type 2 diabetes but research evidence to date is inconclusive. We aimed to increase our understanding of the aetiology of type 2 diabetes by investigating potential interactions between genes and macronutrient intake and their association with the incidence of type 2 diabetes.Methods: We investigated the influence of interactions between genetic risk scores (GRSs) for type 2 diabetes, insulin resistance and BMI and macronutrient intake on the development of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct, a prospective case-cohort study across eight European countries (N = 21,900 with 9742 incident type 2 diabetes cases). Macronutrient intake was estimated from diets reported in questionnaires, including proportion of energy derived from total carbohydrate, protein, fat, plant and animal protein, saturated, monounsaturated and polyunsaturated fat and dietary fibre. Using multivariable-adjusted Cox regression, we estimated country-specific interaction results on the multiplicative scale, using random-effects meta-analysis. Secondary analysis used isocaloric macronutrient substitution.Results: No interactions were identified between any of the three GRSs and any macronutrient intake, with low-to-moderate heterogeneity between countries (I2 range 0-51.6%). Results were similar using isocaloric macronutrient substitution analyses and when weighted and unweighted GRSs and individual SNPs were examined.Conclusions/interpretation: Genetic susceptibility to type 2 diabetes, insulin resistance and BMI did not modify the association between macronutrient intake and incident type 2 diabetes. This suggests that macronutrient intake recommendations to prevent type 2 diabetes do not need to account for differences in genetic predisposition to these three metabolic conditions. [ABSTRACT FROM AUTHOR]
Published: 2018
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437. Circulating Fetuin-A and Risk of Type 2 Diabetes: A Mendelian Randomization Analysis.

Author: Kröger, Janine, Meidtner, Karina, Stefan, Norbert, Guevara, Marcela, Kerrison, Nicola D., Ardanaz, Eva, Aune, Dagfinn, Boeing, Heiner, Dorronsoro, Miren, Dow, Courtney, Fagherazzi, Guy, Franks, Paul W., Freisling, Heinz, Gunter, Marc J., María Huerta, José, Kaaks, Rudolf, Key, Timothy J., Kay Tee Khaw, Krogh, Vittorio, and Kühn, Tilman
Abstract: Fetuin-A, a hepatic-origin protein, is strongly positively associated with risk of type 2 diabetes in human observational studies, but it is unknown whether this association is causal. We aimed to study the potential causal relation of circulating fetuin-A to risk of type 2 diabetes in a Mendelian randomization study with single nucleotide polymorphisms located in the fetuin-A-encoding AHSG gene. We used data from eight European countries of the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study including 10,020 incident cases. Plasma fetuin-A concentration was measured in a subset of 965 subcohort participants and 654 case subjects. A genetic score of the AHSG single nucleotide polymorphisms was strongly associated with fetuin-A (28% explained variation). Using the genetic score as instrumental variable of fetuin-A, we observed no significant association of a 50 µg/mL higher fetuin-A concentration with diabetes risk (hazard ratio 1.02 [95% CI 0.97, 1.07]). Combining our results with those from the DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) consortium (12,171 case subjects) also did not suggest a clear significant relation of fetuin-A with diabetes risk. In conclusion, although there is mechanistic evidence for an effect of fetuin-A on insulin sensitivity and secretion, this study does not support a strong, relevant relationship between circulating fetuin-A and diabetes risk in the general population. [ABSTRACT FROM AUTHOR]
Published: 2018
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438. The Associations of Advanced Glycation End Products and Its Soluble Receptor with Pancreatic Cancer Risk: A Case-Control Study within the Prospective EPIC Cohort

Author: Grote, Verena A. Nieters, Alexandra Kaaks, Rudolf and Tjonneland, Anne Roswall, Nina Overvad, Kim Nielsen, Michael R. Skjelbo Clavel-Chapelon, Francoise Boutron-Ruault, Marie Christine Racine, Antoine Teucher, Birgit Lukanova, Annekatrin Boeing, Heiner Drogan, Dagmar Trichopoulou, Antonia Trichopoulos, Dimitrios Lagiou, Pagona Palli, Domenico Sieri, Sabina Tumino, Rosario Vineis, Paolo and Mattiello, Amalia Argueelles Suarez, Marcial Vicente Duell, Eric J. Sanchez, Maria-Jose Dorronsoro, Miren Huerta Castano, Jose Maria Barricarte, Aurelio Jeurnink, Suzanne M. Peeters, Petra H. M. Sund, Malin Ye, Weimin Regner, Sara and Lindkvist, Bjorn Khaw, Kay-Tee Wareham, Nick Allen, Naomi E. and Crowe, Francesca L. Fedirko, Veronika Jenab, Mazda and Romaguera, Dora Siddiq, Afshan Bueno-de-Mesquita, H. Bas and Rohrmann, Sabine
Abstract: Background: Advanced glycation end products (AGE) and their receptors (RAGE) have been implicated in cancer development through their proinflammatory capabilities. However, prospective data on their association with cancer of specific sites, including pancreatic cancer, are limited. Methods: Prediagnostic blood levels of the AGE product Ne-(carboxymethyl) lysine (CML) and the endogenous secreted receptor for AGE (esRAGE) were measured using ELISA in 454 patients with exocrine pancreatic cancer and individually matched controls within the European Prospective Investigation into Cancer and Nutrition (EPIC). Pancreatic cancer risk was estimated by calculating ORs with corresponding 95% confidence intervals (CI). Results: Elevated CML levels tended to be associated with a reduction in pancreatic cancer risk [OR = 0.57 (95% CI, 0.32-1.01) comparing highest with lowest quintile), whereas no association was observed for esRAGE (OR = 0.98; 95% CI, 0.62-1.54). Adjustments for body mass index and smoking attenuated the inverse associations of CML with pancreatic cancer risk (OR = 0.78; 95% CI, 0.41-1.49). There was an inverse association between esRAGE and risk of pancreatic cancer for cases that were diagnosed within the first 2 years of follow-up [OR = 0.46 (95% CI, 0.22-0.96) for a doubling in concentration], whereas there was no association among those with a longer follow-up (OR = 1.11; 95% CI, 0.88-1.39; P-interaction = 0.002). Conclusions and Impact: Our results do not provide evidence for an association of higher CML or lower esRAGE levels with risk of pancreatic cancer. The role of AGE/RAGE in pancreatic cancer would benefit from further investigations. Cancer Epidemiol Biomarkers Prev; 21(4); 619-28. (C) 2012 AACR.
Published: 2012

439. Total and high-molecular weight adiponectin and risk of colorectal cancer: the European Prospective Investigation into Cancer and Nutrition Study

Author: Aleksandrova, Krasimira Boeing, Heiner Jenab, Mazda and Bueno-de-Mesquita, H. Bas Jansen, Eugene van Duijnhoven, Franzel J. B. Fedirko, Veronika Rinaldi, Sabina Romieu, Isabelle and Riboli, Elio Romaguera, Dora Westphal, Sabine Overvad, Kim and Tjonneland, Anne Boutron-Ruault, Marie Christine and Clavel-Chapelon, Francoise Kaaks, Rudolf Lukanova, Annekatrin and Trichopoulou, Antonia Lagiou, Pagona Trichopoulos, Dimitrios and Agnoli, Claudia Mattiello, Amalia Saieva, Calogero and Vineis, Paolo Tumino, Rosario Peeters, Petra H. Argueelles, Marcial Bonet, Catalina Sanchez, Maria-Jose Dorronsoro, Miren Huerta, Jose-Maria Barricarte, Aurelio Palmqvist, Richard Hallmans, Goran Khaw, Kay-Tee Wareham, Nick and Allen, Naomi E. Crowe, Francesca L. Pischon, Tobias
Subjects: food and beverages
Abstract: Adiponectin an adipose tissue-derived protein may provide a molecular link between obesity and colorectal cancer (CRC), but evidence from large prospective studies is limited. In particular, no epidemiological study explored high-molecular weight (HMW) and non-HMW adiponectin fractions in relation to CRC risk, despite them being hypothesized to have differential biological activities, i.e. regulating insulin sensitivity (HMW adiponectin) versus inflammatory response (non-HNW adiponectin). In a prospective, nested case control study, we investigated whether prediagnostic serum concentrations of total, HMW and non-HMW adiponectin are associated with risk of CRC, independent of obesity and other known CRC risk factors. A total of 1206 incident cases (755 colon and 451 rectal) were matched to 1206 controls using incidence-density sampling. In conditional logistic regression, adjusted for dietary and lifestyle factors, total adiponectin and non-HMW adiponectin concentrations were inversely associated with risk of CRC [relative risk (RR) comparing highest versus lowest quintile = 0.71, 95% confidence interval (CI) = 0.53-0.95, P-trend = 0.03 for total adiponectin and RR = 0.45, 95% Cl = 0.34-0.61, P-trend < 0.0001 for non-HMW adiponectin] HMW adiponectin concentrations were not associated with CRC risk (RR = 0.91, 95% Cl = 0.68-1.22, P-trend = 0.55). Non-HMW adiponectin was associated with CRC risk even after adjustment for body mass index and waist circumference (RR = 0.39, 95% CI = 0.26-0.60, P-trend < 0.0001), whereas the association with total adiponectin was no longer significant (RR = 0.81, 95% CI = 0.60A.09, P-trend = 0.23). When stratified by cancer site, non-HMW adiponectin was inversely associated with both colon and rectal cancer. These findings suggest an important role of the relative proportion of non-HMW adiponectin in CRC pathogenesis. Future studies are warranted to confirm these results and to elucidate the underlying mechanisms.
Published: 2012

440. Dietary Fibre Intake and Risks of Cancers of the Colon and Rectum in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author: Murphy, Neil Norat, Teresa Ferrari, Pietro Jenab, Mazda and Bueno-de-Mesquita, Bas Skeie, Guri Dahm, Christina C. and Overvad, Kim Olsen, Anja Tjonneland, Anne Clavel-Chapelon, Francoise Boutron-Ruault, Marie Christine Racine, Antoine and Kaaks, Rudolf Teucher, Birgit Boeing, Heiner Bergmann, Manuela M. Trichopoulou, Antonia Trichopoulos, Dimitrios and Lagiou, Pagona Palli, Domenico Pala, Valeria Panico, Salvatore Tumino, Rosario Vineis, Paolo Siersema, Peter and van Duijnhoven, Franzel Peeters, Petra H. M. Hjartaker, Anette and Engeset, Dagrun Gonzalez, Carlos A. Sanchez, Maria-Jose and Dorronsoro, Miren Navarro, Carmen Ardanaz, Eva Quiros, Jose R. Sonestedt, Emily Ericson, Ulrika Nilsson, Lena and Palmqvist, Richard Khaw, Kay-Tee Wareham, Nick Key, Timothy J. Crowe, Francesca L. Fedirko, Veronika Wark, Petra A. and Chuang, Shu-Chun Riboli, Elio
Abstract: Background: Earlier analyses within the EPIC study showed that dietary fibre intake was inversely associated with colorectal cancer risk, but results from some large cohort studies do not support this finding. We explored whether the association remained after longer follow-up with a near threefold increase in colorectal cancer cases, and if the association varied by gender and tumour location. Methodology/Principal Findings: After a mean follow-up of 11.0 years, 4,517 incident cases of colorectal cancer were documented. Total, cereal, fruit, and vegetable fibre intakes were estimated from dietary questionnaires at baseline. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models stratified by age, sex, and centre, and adjusted for total energy intake, body mass index, physical activity, smoking, education, menopausal status, hormone replacement therapy, oral contraceptive use, and intakes of alcohol, folate, red and processed meats, and calcium. After multivariable adjustments, total dietary fibre was inversely associated with colorectal cancer (HR per 10 g/day increase in fibre 0.87, 95% CI: 0.79-0.96). Similar linear associations were observed for colon and rectal cancers. The association between total dietary fibre and risk of colorectal cancer risk did not differ by age, sex, or anthropometric, lifestyle, and dietary variables. Fibre from cereals and fibre from fruit and vegetables were similarly associated with colon cancer; but for rectal cancer, the inverse association was only evident for fibre from cereals. Conclusions/Significance: Our results strengthen the evidence for the role of high dietary fibre intake in colorectal cancer prevention.
Published: 2012

441. Longitudinal changes in weight in relation to smoking cessation in participants of the EPIC-PANACEA study

Author: Travier, Noemie Agudo, Antonio May, Anne M. Gonzalez, Carlos and Luan, Jian'an Wareham, Nick J. Bueno-de-Mesquita, H. Bas and van den Berg, Saskia W. Slimani, Nadia Rinaldi, Sabina and Clavel-Chapelon, Francoise Boutron-Ruault, Marie-Christine and Palli, Domenico Sieri, Sabina Mattiello, Amalia Tumino, Rosario Vineis, Paolo Norat, Teresa Romaguera, Dora and Rodriguez, Laudina Sanchez, Maria-Jose Dorronsoro, Miren and Barricarte, Aurelio Huerta, Jose M. Key, Tim J. Orfanos, Philippos Naska, Androniki Trichopoulou, Antonia Rohrmann, Sabina Kaaks, Rudolf Bergmann, Manuela M. Boeing, Heiner and Hallmans, Goran Johansson, Ingegerd Manjer, Jonas Lindkvist, Bjorn Jakobsen, Mariane U. Overvad, Kim Tjonneland, Anne and Halkjaer, Jytte Lund, Eiliv Braaten, Toni Odysseos, Andreani and Riboli, Elio Peeters, Petra H.
Abstract: Purpose. We assessed the association between smoking cessation and prospective weight change in the European population of the European Prospective Investigation into Cancer and Nutrition-Physical Activity, Nutrition, Alcohol, Cessation of smoking. Eating out of home And obesity (EPIC-PANACEA) project. Methods. The study involved more than 300,000 healthy volunteers, recruited between 1992 and 2000 in 9 European countries, who provided data on anthropometry and smoking habits at baseline and after a follow-up of 5 years on average. Adjusted mixed-effects linear regression models were used to obtain sex-specific summary estimates of the association between the change in smoking status and the annual change in weight. Results. Smoking cessation tends to be followed by weight gain; when compared to stable smokers, annual weight gain was higher in men (0.44 kg (95%CI: 0.36; 0.52)) and women (0.46 kg (95%CI: 0.41; 0.52)) who stopped smoking during follow-up. When smokers who stopped smoking at least 1 year before recruitment were compared to never smokers, no major differences in annual weight gain were observed. The excess weight gain following smoking cessation appears to mainly occur in the first years following the cessation. Conclusions. When considering the benefits of smoking cessation, such findings strengthen the need for promoting cessation offering information on weight gain control and support to weight-concerned smokers in order to remove a barrier to quitting. (C) 2011 Elsevier Inc. All rights reserved.
Published: 2012

442. Coffee and tea consumption and the risk of ovarian cancer: a prospective cohort study and updated meta-analysis

Author: Braem, Marieke G. M. Onland-Moret, N. Charlotte Schouten, Leo J. and Tjonneland, Anne Hansen, Louise Dahm, Christina C. and Overvad, Kim Lukanova, Annekatrin Dossus, Laure Floegel, Anna Boeing, Heiner Clavel-Chapelon, Francoise and Chabbert-Buffet, Nathalie Fagherazzi, Guy Trichopoulou, Antonia and Benetou, Vassiliki Goufa, Ioulia Pala, Valeria Galasso, Rocco Mattiello, Amalia Sacerdote, Carlotta Palli, Domenico and Tumino, Rosario Gram, Inger T. Lund, Eiliv Gavrilyuk, Oxana Sanchez, Maria-Jose Quiros, Ramon Gonzales, Carlos A. and Dorronsoro, Miren Huerta Castano, Jose M. Barricarte Gurrea, Aurelio Idahl, Annika Ohlson, Nina Lundin, Eva Jirstrom, Karin Witfalt, Elisabet Allen, Naomi E. Tsilidis, Konstantinos K. Kaw, Kay-Tee Bueno-de-Mesquita, H. Bas Dik, Vincent K. Rinaldi, Sabina Fedirko, Veronika Norat, Teresa and Riboli, Elio Kaaks, Rudolf Peeters, Petra H. M.
Abstract: Background: In 2007 the World Cancer Research Fund Report concluded that there was limited and inconsistent evidence for an effect of coffee and tea consumption on the risk of epithelial ovarian cancer (EOC). Objective: In the European Prospective Investigation into Cancer and Nutrition (EPIC), we aimed to investigate whether coffee intakes, tea intakes, or both are associated with the risk of EOC. Design: All women participating in the EPIC (n = 330,849) were included in this study. Data on coffee and tea consumption were collected through validated food-frequency questionnaires at baseline. HRs and 95% CIs were estimated by using Cox proportional hazards models. Furthermore, we performed an updated meta-analysis of all previous prospective studies until April 2011 by comparing the highest and lowest coffee- and tea-consumption categories as well as by using dose-response random-effects meta-regression analyses. Results: During a median follow-up of 11.7 y, 1244 women developed EOC. No association was observed between the risk of EOC and coffee consumption [HR: 1.05 (95% CI: 0.75, 1.46) for the top quintile compared with no intake] or tea consumption [HR: 1.07 (95% Cl: 0.78, 1.45) for the top quintile compared with no intake]. This lack of association between coffee and tea intake and EOC risk was confirmed by the results of our meta-analysis. Conclusion: Epidemiologic studies do not provide sufficient evidence to support an association between coffee and tea consumption and risk of ovarian cancer. Am J Clin Nutr 2012;95:1172-81.
Published: 2012

443. Cigarette smoking and risk of histological subtypes of epithelial ovarian cancer in the EPIC cohort study

Author: Gram, Inger T. Lukanova, Annekatrin Brill, Ilene Braaten, Tonje Lund, Eiliv Lundin, Eva Overvad, Kim Tjonneland, Anne Clavel-Chapelon, Francoise Chabbert-Buffet, Nathalie and Bamia, Christina Trichopoulou, Antonia Zylis, Dimosthenis and Masala, Giovanna Berrino, Franco Galasso, Rocco Tumino, Rosario Sacerdote, Carlotta Gavrilyuk, Oxana Kristiansen, Steinar Rodriguez, Laudina Bonet, Catalina Maria Huerta, Jose Barricarte, Aurelio Sanchez, Maria-Jose Dorronsoro, Miren Jirstrom, Karin Almquist, Martin Idahl, Annika and Bueno-de-Mesquita, H. Bas Braem, Marie Onland-Moret, Charlotte and Tsilidis, Konstantinos K. Allen, Naomi E. Fedirko, Veronika and Riboli, E. Kaaks, Rudolf
Abstract: New data regarding a positive association between smoking and risk of epithelial ovarian cancer (EOC), especially the mucinous tumor type, has started to emerge. The purpose of this study was to examine the association between different measures of smoking exposures and subtypes of EOC in a large cohort of women from 10 European countries. The European Prospective Investigation into Cancer and Nutrition (EPIC) cohort is a multicenter prospective study initiated in 1992. The questionnaires included data about dietary, lifestyle, and health factors. Information about cigarette smoking was collected from individuals in all participating countries. We used Cox proportional hazard regression models to estimate hazard ratio (HR) of EOC overall and serous, mucinous, and endometroid histological subtypes, with 95% confidence intervals (CIs) associated with different measures of smoking exposures adjusting for confounding variables. Altogether 836 incident EOC cases were identified among 326,831 women. The tumors were classified as 400 serous, 83 mucinous, 80 endometroid, 35 clear cell, and 238 unspecified. Compared with never smokers, current smokers had a significantly increased risk for mucinous tumors [HR = 1.85 (95% CI 1.083.16)] and those smoking more than 10 cigarettes per day had a doubling in risk [HR = 2.25(95% CI 1.264.03)] as did those who had smoked less than 15 pack-years of cigarettes [HR = 2.18 (95% CI 1.074.43)]. The results from the EPIC study add further evidence that smoking increases risk of mucinous ovarian cancer and support the notion that the effect of smoking varies according to histological subtype.
Published: 2012

444. Prediagnostic 25-Hydroxyvitamin D, VDR and CASR Polymorphisms, and Survival in Patients with Colorectal Cancer in Western European Populations

Author: Fedirko, Veronika Riboli, Elio Tjonneland, Anne Ferrari, Pietro Olsen, Anja Bueno-de-Mesquita, H. Bas van Duijnhoven, Franzel J. B. Norat, Teresa Jansen, Eugene H. J. M. Dahm, Christina C. Overvad, Kim Boutron-Ruault, Marie-Christine and Clavel-Chapelon, Francoise Racine, Antoine Lukanova, Annekatrin and Teucher, Birgit Boeing, Heiner Aleksandrova, Krasimira and Trichopoulou, Antonia Benetou, Vassiliki Trichopoulos, Dimitrios and Grioni, Sara Vineis, Paolo Panico, Salvatore Palli, Domenico Tumino, Rosario Siersema, Peter D. Peeters, Petra H. Skeie, Guri Brustad, Magritt Chirlaque, Maria-Dolores and Barricarte, Aurelio Ramon Quiros, Jose Jose Sanchez, Maria and Dorronsoro, Miren Bonet, Catalina Palmqvist, Richard and Hallmans, Goran Key, Timothy J. Crowe, Francesca Khaw, Kay-Tee Wareham, Nick Romieu, Isabelle McKay, James and Wark, Petra A. Romaguera, Dora Jenab, Mazda
Abstract: Background: Individuals with higher blood 25-hydroxyvitamin D [25(OH)D] levels have a lower risk of developing colorectal cancer (CRC), but the influence of 25(OH)D on mortality after CRC diagnosis is unknown. Methods: The association between prediagnostic 25(OH)D levels and CRC-specific (N 444) and overall mortality (N 541) was prospectively examined among 1,202 participants diagnosed with CRC between 1992 and 2003 in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Multivariable Cox proportional hazards models were used to calculate HRs and corresponding 95% CIs according to 25(OH)D quintiles and genetic variation within the VDR and CASR genes. Potential dietary, lifestyle, and metabolic effect modifiers were also investigated. Results: There were 541 deaths, 444 (82%) due to CRC. Mean follow-up was 73 months. In multivariable analysis, higher 25(OH)D levels were associated with a statistically significant reduction in CRC-specific (P-trend 0.04) and overall mortality (P-trend =0.01). Participants with 25(OH)D levels in the highest quintile had an adjusted HR of 0.69 (95% CI: 0.50-0.93) for CRC-specific mortality and 0.67 (95% CI: 0.50-0.88) for overall mortality, compared with the lowest quintile. Except for a possible interaction by prediagnostic dietary calcium intake (P-interaction = 0.01), no other potential modifying factors related to CRC survival were noted. The VDR (FokI and BsmI) and CASR (rs1801725) genotypes were not associated with survival. Conclusions: High prediagnostic 25(OH) D levels are associated with improved survival of patients with CRC. Impact: Our findings may stimulate further research directed at investigating the effects of blood vitamin D levels before, at, and after CRC diagnosis on outcomes in CRC patients. Cancer Epidemiol Biomarkers Prev; 21(4); 582-93. (C) 2012 AACR.
Published: 2012

445. Re: Hepatocellular Carcinoma Risk factors and Disease Burden in a European Cohort: A Nested Case-Control Study Response

Author: Trichopoulos, Dimitrios Bamia, Christina Lagiou, Pagona and Fedirko, Veronika Trepo, Elisabeth Jenab, Mazda Pischon, Tobias Nthlings, Ute Overvad, Kim Tjonneland, Anne and Outzen, Malene Clavel-Chapelon, Francoise Kaaks, Rudolf and Lukanova, Annekatrin Boeing, Heiner Aleksandrova, Krasimira and Benetou, Vassiliki Zylis, Dimosthenis Palli, Domenico Pala, Valeria Panico, Salvatore Tumino, Rosario Sacerdote, Carlotta Bueno-De-Mesquita, H. Bas Van Kranen, Henk J. and Peeters, Petra H. M. Lund, Eiliv Ramon Quiros, J. Gonzalez, Carlos A. Sanchez Perez, Maria-Jose Navarro, Carmen and Dorronsoro, Miren Barricarte, Aurelio Lindkvist, Bjoern and Regner, Sara Werner, Marten Hallmans, Gran Khaw, Kay-Tee and Wareham, Nick Key, Timothy Romieu, Isabelle Chuang, Shu-Chun and Murphy, Neil Boffetta, Paolo Trichopoulou, Antonia and Riboli, Elio
Published: 2012

446. Olive oil intake and breast cancer risk in the Mediterranean countries of the European Prospective Investigation into Cancer and Nutrition study

Author: Buckland, Genevieve Travier, Noemie Agudo, Antonio and Fonseca-Nunes, Ana Navarro, Carmen Lagiou, Pagona Demetriou, Christiana Amiano, Pilar Dorronsoro, Miren Chirlaque, Maria-Dolores Huerta, Jose-Maria Molina, Esther Sanchez Perez, Maria-Jose Ardanaz, Eva Moreno-Iribas, Conchi Ramon Quiros, J. Naska, Androniki Trichopoulos, Dimitrios and Giurdanella, Maria Concetta Tumino, Rosario Agnoli, Claudia and Grioni, Sara Panico, Salvatore Mattiello, Amalia Masala, Giovanna Sacerdote, Carlotta Polidoro, Silvia Palli, Domenico Trichopoulou, Antonia Gonzalez, Carlos A.
Abstract: Although there is some evidence suggesting that olive oil could reduce breast cancer (BC) risk, the epidemiological data are still relatively limited, not entirely consistent and mainly based on casecontrol studies. Therefore, we prospectively assessed the association between olive oil and BC risk in postmenopausal women from the Mediterranean cohorts within the European Prospective Investigation into Cancer and Nutrition. The analysis included 62,284 postmenopausal women recruited from Spain, Italy and Greece who had complete dietary data (collected from validated country-specific dietary questionnaires). The risk of BC (overall and by hormone receptor subtypes) was assessed using hazards ratios (HRs) obtained from Cox proportional hazards regression, while adjusting for known BC risk factors. After a mean follow-up of 9 years, 1,256 women were diagnosed with a primary incident invasive BC. The multivariate HRs for BC risk by olive oil intake (highest vs. lowest tertile of g/day/2,000 kcal) were 1.07 (95% CI = 0.911.25) in the adjusted model, 1.06 (95% CI = 0.911.24) in the model additionally adjusted for reproductive-related factors and 1.10 (95% CI = 0.921.31) for the model additionally adjusted for dietary factors. There was no association between olive oil and risk of estrogen or progesterone receptor-positive tumors, but a suggestion of a negative association with estrogens and progesterone receptor-negative tumors. The results from our prospective study showed that olive oil consumption during adult life was not associated with the risk of BC. However, larger prospective studies are still needed to explore possible differences related to hormone receptor status.
Published: 2012

447. Biomarkers of Oxidative Stress and Risk of Developing Colorectal Cancer: A Cohort-nested Case-Control Study in the European Prospective Investigation Into Cancer and Nutrition

Author: Leufkens, Anke M. van Duijnhoven, Franzel J. B. Woudt, Sjoukje H. S. Siersema, Peter D. Jenab, Mazda Jansen, Eugene H. J. M. Pischon, Tobias Tjonneland, Anne Olsen, Anja Overvad, Kim Boutron-Ruault, Marie Christine Clavel-Chapelon, Francoise and Morois, Sophie Palli, Domenico Pala, Valeria Tumino, Rosario Vineis, Paolo Panico, Salvatore Kaaks, Rudolf and Lukanova, Annekatrin Boeing, Heiner Aleksandrova, Krasimira and Trichopoulou, Antonia Trichopouios, Dimitrios Dilis, Vardis and Peeters, Petra H. Skeie, Guri Gonzalez, Carlos A. and Argueelles, Marcial Sanchez, Maria-Jose Dorronsoro, Miren and Huerta, Jose Maria Ardanaz, Eva Hallmans, Goran Palmqvist, Richard Khaw, Kay-Tee Wareham, Nick Allen, Naomi E. and Crowe, Francesca L. Fedirko, Veronika Norat, Teresa Riboli, Elio Bueno-de-Mesquita, H. Bas
Abstract: Oxidative stress has been shown to play an important role in carcinogenesis, but prospective evidence for an association between biomarkers of oxidative stress and colorectal cancer (CRC) risk is limited. The authors investigated the association between prediagnostic serum levels of oxidative stress indicators (i.e., reactive oxygen metabolites (ROM) and ferric reducing ability of plasma (FRAP)) and CRC risk. This was examined in a nested case-control study (1,064 CRC cases, 1,064 matched controls) in the European Prospective Investigation Into Cancer and Nutrition cohort (1992-2003). Incidence rate ratios and 95% confidence intervals were calculated using conditional logistic regression analyses. ROM were associated with overall CRC risk (highest tertile vs. lowest: adjusted incidence rate ratio (IRRadj) = 1.91, 95% confidence interval (CI): 1.47, 2.48), proximal (IRRadj = 1.89, 95% CI: 1.06, 3.36) and distal (IRRadj = 2.31, 95% CI: 1.37, 3.89) colon cancer, and rectal cancer (IRRadj = 1.69, 95% CI: 1.05, 2.72). When results were stratified by tertile of follow-up time, the association remained significant only in participants with less than 2.63 years of follow-up (IRRadj = 2.28, 95% CI: 1.78, 2.94; P-heterogeneity < 0.01). FRAP was not associated with CRC risk. In conclusion, prediagnostic serum ROM levels were associated with increased risk of CRC. However, this association was seen only in subjects with relatively short follow-up, suggesting that the association results from production of reactive oxygen species by preclinical tumors.
Published: 2012

448. Fiber intake and total and cause-specific mortality in the European Prospective Investigation into Cancer and Nutrition cohort

Author: Chuang, Shu-Chun Norat, Teresa Murphy, Neil Olsen, Anja and Tjonneland, Anne Overvad, Kim Boutron-Ruault, Marie Christine and Perquier, Florence Dartois, Laureen Kaaks, Rudolf and Teucher, Birgit Bergmann, Manuela M. Boeing, Heiner and Trichopoulou, Antonia Lagiou, Pagona Trichopoulos, Dimitrios and Grioni, Sara Sacerdote, Carlotta Panico, Salvatore Palli, Domenico Tumino, Rosario Peeters, Petra H. M. and Bueno-de-Mesquita, Bas Ros, Martine M. Brustad, Magritt and Asli, Lene Angell Skeie, Guri Quiros, J. Ramon Gonzalez, Carlos A. Sanchez, Maria-Jose Navarro, Carmen Aicua, Eva Ardanaz Dorronsoro, Miren Drake, Isabel Sonestedt, Emily and Johansson, Ingegerd Hallmans, Goeran Key, Timothy Crowe, Francesca Khaw, Kay-Tee Wareham, Nicholas Ferrari, Pietro and Slimani, Nadia Romieu, Isabelle Gallo, Valentina Riboli, Elio Vineis, Paolo
Abstract: Background: Previous studies have shown that high fiber intake is associated with lower mortality. However, little is known about the association of dietary fiber with specific causes of death other than cardiovascular disease (CVD). Objective: The aim of this study was to assess the relation between fiber intake, mortality, and cause-specific mortality in a large European prospective study of 452,7 I 7 men and women. Design: HRs and 95% CIs were estimated by using Cox proportional hazards models, stratified by age, sex, and center and adjusted for education, smoking, alcohol consumption, BMI, physical activity, total energy intake, and, in women, ever use of menopausal hormone therapy. Results: During a mean follow-up of 12.7 y, a total of 23,582 deaths were recorded. Fiber intake was inversely associated with total mortality (HRper (10-g/d) (increase): 0.90; 95% Cl: 0.88, 0.92); with mortality from circulatory (HRper (10-g/d increase): 0.90 and 0.88 for men and women, respectively), digestive (HR: 0.61 and 0.64), respiratory (HR: 0.77 and 0.62), and non-CVD noncancer inflammatory (HR: 0.85 and 0.80) diseases; and with smoking-related cancers (HR: 0.86 and 0.89) but not with non-smoking-related cancers (HR: 1.05 and 0.97). The associations were more evident for fiber from cereals and vegetables than from fruit. The associations were similar across BMI and physical activity categories but were stronger in smokers and participants who consumed >18 g alcohol/d. Conclusions: Higher fiber intake is associated with lower mortality, particularly from circulatory, digestive, and non-CVD noncancer inflammatory diseases. Our results support current recommendations of high dietary fiber intake for health maintenance. Am J Clin Nutr 2012;96:164-74.
Published: 2012

449. Is concordance with World Cancer Research Fund/American Institute for Cancer Research guidelines for cancer prevention related to subsequent risk of cancer? Results from the EPIC study

Author: Romaguera, Dora Vergnaud, Anne-Claire Peeters, Petra H. van Gils, Carla H. Chan, Doris S. M. Ferrari, Pietro Romieu, Isabelle Jenab, Mazda Slimani, Nadia Clavel-Chapelon, Francoise Fagherazzi, Guy Perquier, Florence Kaaks, Rudolf and Teucher, Birgit Boeing, Heiner von Ruesten, Anne and Tjonneland, Anne Olsen, Anja Dahm, Christina C. Overvad, Kim and Ramon Quiros, Jose Gonzalez, Carlos A. Jose Sanchez, Maria and Navarro, Carmen Barricarte, Aurelio Dorronsoro, Miren and Khaw, Kay-Tee Wareham, Nicholas J. Crowe, Francesca L. Key, Timothy J. Trichopoulou, Antonia Lagiou, Pagona Bamia, Christina Masala, Giovanna Vineis, Paolo Tumino, Rosario and Sieri, Sabina Panico, Salvatore May, Anne M. and Bueno-de-Mesquita, H. Bas Buechner, Frederike L. Wirfaelt, Elisabet Manjer, Jonas Johansson, Ingegerd Hallmans, Goeran and Skeie, Guri Benjaminsen Borch, Kristin Parr, Christine L. and Riboli, Elio Norat, Teresa
Abstract: Background: In 2007 the World Cancer Research Fund (WCRF) and the American Institute of Cancer Research (AICR) issued 8 recommendations (plus 2 special recommendations) on diet, physical activity, and weight management for cancer prevention on the basis of the most comprehensive collection of available evidence. Objective: We aimed to investigate whether concordance with the WCRF/AICR recommendations was related to cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Design: The present study included 386,355 EPIC participants from 9 European countries. At recruitment, dietary, anthropometric, and lifestyle information was collected. A score was constructed based on the WCRF/AICR recommendations on weight management, physical activity, foods and drinks that promote weight gain, plant foods, animal foods, alcoholic drinks, and breastfeeding for women; the score range was 0-6 for men and 0-7 for women. Higher scores indicated greater concordance with WCRF/AICR recommendations. The association between the score and cancer risk was estimated by using multivariable Cox regression models. Results: Concordance with the score was significantly associated with decreased risk of cancer. A 1-point increment in the score was associated with a risk reduction of 5% (95% Cl: 3%, 7%) for total cancer, 12% (95% CI: 9%, 16%) for colorectal cancer, and 16% (95% CI: 9%, 22%) for stomach cancer. Significant associations were also observed for cancers of the breast, endometrium, lung, kidney, upper aerodigestive tract, liver, and esophagus but not for prostate, ovarian, pancreatic, and bladder cancers. Conclusion: Adherence to the WCRF/AICR recommendations for cancer prevention may lower the risk of developing most types of cancer. Am J Clin Nutr 2012;96:150-63.
Published: 2012

450. Prediagnostic Circulating Parathyroid Hormone Concentration and Colorectal Cancer in the European Prospective Investigation into Cancer and Nutrition Cohort

Author: Fedirko, Veronika Riboli, Elio Bueno-de-Mesquita, H. Bas and Rinaldi, Sabina Pischon, Tobias Norat, Teresa Jansen, Eugene H. J. M. van Duijnhoven, Fraenzel J. B. Tjonneland, Anne and Olsen, Anja Overvad, Kim Boutron-Ruault, Marie-Christine and Clavel-Chapelon, Francoise Engel, Pierre Kaaks, Rudolf and Teucher, Birgit Boeing, Heiner Buijsse, Brian Trichopoulou, Antonia Trichopoulos, Dimitrios Lagiou, Pagona Sieri, Sabina and Vineis, Paolo Panico, Salvatore Palli, Domenico Tumino, Rosario van Gils, Carla H. Peeters, Petra H. M. Chirlaque, Maria-Dolores Barricarte Gurrea, Aurelio Rodriguez, Laudina and Molina-Montes, Esther Dorronsoro, Miren Bonet, Catalina and Palmqvist, Richard Hallmans, Goran Key, Timothy J. Tsilidis, Konstantinos K. Khaw, Kay-Tee Romieu, Isabelle Straif, Kurt and Wark, Petra A. Romaguera, Dora Jenab, Mazda
Abstract: Background: Parathyroid hormone (PTH) has been proposed to play a promoting role in carcinogenesis. However, no epidemiologic studies have yet directly investigated its role in colorectal cancer (CRC). Methods: A case-control study nested within the European Prospective Investigation into Cancer and Nutrition cohort was conducted with 1,214 incident, sporadic CRC cases matched to 1,214 controls. Circulating prediagnostic PTH and 25-hydroxy vitamin D [25(OH) D] concentrations were measured by enzyme-linked immunosorbent assays. Detailed dietary and lifestyle questionnaire data were collected at baseline. Multivariable conditional logistic regression was used to estimate the incidence rate ratio (RR) with 95% confidence intervals (95% CI) for the association between circulating PTH and CRC risk. Results: In multivariate analyses [including adjustment for 25(OH) D concentration] with a priori defined cutoff points, high levels of serum PTH (>= 65 ng/L) compared with medium PTH levels of 30-65 ng/L were associated with increased CRC risk (RR = 1.41,95% CI: 1.03-1.93). In analyses by sex, the CRC risk was 1.77 (95% CI: 1.14-2.75) and 1.15 (95% CI: 0.73-1.84) in men and women, respectively (P-heterogeneity = 0.01). In subgroup analyses by anatomical subsite, the risk for colon cancer was RR = 1.56, 95% CI: 1.03-2.34, and for rectal cancer RR = 1.20, 95% CI: 0.72-2.01 (P-heterogeneity = 0.21). Effect modification by various risk factors was examined. Conclusions: The results of this study suggest that high serum PTH levels may be associated with incident, sporadic CRC in Western European populations, and in particular among men. Impact: To our knowledge, this is the first study on PTH and CRC. The role of PTH in carcinogenesis needs to be further investigated. Cancer Epidemiol Biomarkers Prev; 20(5); 767-78. (C)2011 AACR.
Published: 2011

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