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The article focuses on a 62-year-old man who was diagnosed with chronic myeloid leukaemia (CML). Topics discussed include swelling of his right buttock and leg on treatment with analgesia; improved relief to pain through embolisation; and use of bone marrow biopsies for investigation of haematological diseases.

Traditionally, high-latitude dendroclimatic studies have focused on measurements of total ring width (RW), with the maximum density of the latewood (MXD) serving as a complementary variable. Whilst MXD has typically improved the strength of the growing season climate connection over that of RW, its measurements are costly and time-consuming. Recently, a less costly and more time-efficient technique to extract density measurements has emerged, based on lignin's propensity to absorb blue light. This Blue Intensity (BI) methodology is based on image analyses of finely-sanded core samples, and the relative ease with which density measurements can be extracted allows for significant increases in spatio-temporal sample depth. While some studies have attempted to combine RW and MXD as predictors for summer temperature reconstructions, here we evaluate a systematic comparison of the climate signal for RW and latewood BI (LWBI) separately, using a recently updated and expanded tree ring database for Labrador, Canada. We demonstrate that while RW responds primarily to climatic drivers earlier in the growing season (January–April), LWBI is more responsive to climate conditions during late spring and summer (May–August). Furthermore, RW appears to be driven primarily by large-scale atmospheric dynamics associated with the Pacific North American pattern, whilst LWBI is more closely associated with local climate conditions, themselves linked to the behaviour of the Atlantic Multidecadal Oscillation. Lastly, we demonstrate that anomalously wide or narrow growth rings consistently respond to the same climate drivers as average growth years, whereas the sensitivity of LWBI to extreme climate conditions appears to be enhanced. [ABSTRACT FROM AUTHOR]

Beef female stayability (STAY), as defined by the Red Angus Association of America (RAAA), is the ability of a female to produce five consecutive calves by six years of age given she produced as a heifer. Stayability has been described as an economically relevant trait, and the magnitude of the value placed on STAY in various commercially available general purpose economic selection indices indicates its value to producers is greater than any other trait included in those indices. Given the importance of STAY to the profitability of commercial beef operations, the objective of this study was to identify QTL associated with STAY in Red Angus cattle. A genome-wide association study (GWAS) was performed using deregressed STAY EBV, calculated using a single trait animal model and three generation pedigree formed using data for the national cattle evaluation in December 2014 for the RAAA. Initially, animals were genotyped using various Illumina SNP chip-platforms ranging in density from 32,186 to 140,114 SNP. Genotypes were then imputed with FImpute so each animal possessed 74,659 SNP genotypes. Individual animals whose breed percent was >50 percent Red Angus with a deregressed EBV reliability of >0.05 were merged with the genotype file and marker quality control was performed. Criteria for sifting genotypes consisted of removing those markers where the average call rate was <0.85, minor allele frequency <0.01, those not in Hardy-Weinberg equilibrium (P < 0.0001), and those SNP in extreme LD (r² > 0.99). These criteria resulted in 2,664 animals with 62,807 SNP available for GWAS. Genomic windows of approximately 1 Mb (25.12 ± 8.31 SNP) in size were determined to significantly influence stayability if the size of their effect explained greater than 0.75% of the genetic variance in the trait. Association studies were performed using Bayes B methodology in the software package GenSel. Twelve marker windows were identified as QTL associated with STAY. These windows were located on BTA 2, 5, 6, 9, 12, 15, and 16. On two chromosomes, 9 and 15, multiple windows were identified (3 and 4, respectively). Although these are the first set of markers reported to be associated with STAY in Bos taurus beef cattle, similar chromosomes were identified in GWAS involving Nellore-Angus crossbred cows (BTA4, 5, 15, 19) for STAY, as well as for calving interval (BTA 5) and productive lifespan (BTA 15) in dairy cattle. [ABSTRACT FROM AUTHOR]

The poem "Lycidas," by B. J. Buckley is presented. First Line: Becalmed; Last Line: and cresting calms your face, your emptied arms.

The article presents the poem "That Whuch We Cannot Speak of We Must Pass Over in Silence," by B.J. Buckley. First Line: Therefore grass, breathless; Last Line: word.

Diabet. Med. 29, 844-854 (2012) Abstract Background Gestational diabetes mellitus is a potentially serious condition that affects many pregnancies and its prevalence is increasing. Evidence suggests early detection and treatment improves outcomes, but this is hampered by continued disagreement and inconsistency regarding many aspects of its diagnosis. Methods The Vitamin D and Lifestyle Intervention for Gestational Diabetes Mellitus Prevention (DALI) research programme aims to promote pan-European standards in the detection and diagnosis of gestational diabetes and to develop effective preventive interventions. To provide an overview of the context within which the programme will be conducted and its findings interpreted, systematic searching and narrative synthesis have been used to identify and review the best available European evidence relating to the prevalence of gestational diabetes, current screening practices and barriers to screening. Results Prevalence is most often reported as 2-6% of pregnancies. Prevalence may be lower towards the Northern Atlantic seaboard of Europe and higher in the Southern Mediterranean seaboard. Screening practice and policy is inconsistent across Europe, hampered by lack of consensus on testing methods, diagnostic glycaemic thresholds and the value of routine screening. Poor clinician awareness of gestational diabetes, its diagnosis and local clinical guidelines further undermine detection of gestational diabetes. Conclusions Europe-wide agreement on screening approaches and diagnostic standards for gestational diabetes could lead to better detection and treatment, improved outcomes for women and children and a strengthened evidence base. There is an urgent need for well-designed research that can inform decisions on best practice in gestational diabetes mellitus screening and diagnosis. [ABSTRACT FROM AUTHOR]

The poem "Judas," by B. J. Buckley is presented. First Line: There are bones behind me; Last Line: sing.

The poem "Agnus Dei," by B. J. Buckley is presented. First Line: Crows watch us butchering lambs; Last Line: bedrock of bone.

The poem "Equinox," by B. J. Buckley is presented. First Line: Wind from the western; Last Line: of fire.