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This paper proposed an algorithm of extracting feature points based on multiple parameters hybridization method,which aimed to solve the problem that previous algorithms existed,including sharp feature points extraction were incomplete,and could not retain boundary points. Firstly,this algorithm constructed a k-d tree to establish K-nearest neighborhood of the point cloud. Then,it calculated the data point curvature,average vector angle between the point and its K-nearest neighborhood points,distance from point to its neighborhood gravity center,average distance from point to its neighborhood points for each K-nearest neighborhood. Finally,according to the four parameters,it defined the characteristic threshold and feature discriminant parameter. A point recognized as the feature point when its value of discriminant parameter was bigger than the threshold. Compared with existing algorithms,the proposed algorithm can not only extract the steep feature points,but also have the ability to identify the boundary points. [ABSTRACT FROM AUTHOR]

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Objective To investigate the effects of thymoquinone (TQ) on the levels of proteins involved in oxidative stress and cytokine in the brain of rats with type 2 diabetes mellitus. Methods Wistar rats (n=48) were randomly divided into 3 groups:normal control group, model group and TQ treatment group (n=16). The normal control group was fed with clean grade ordinary feed. The model group and TQ treatment group rats were fed with high-glucose and high-fat diet. After 6 weeks’ feeding, model group and TQ treatment group rats were administered streptozocin (STZ) (35 mg/kg) to establish type 2 diabetic model by intraperitoneal injection. Then, the model group and TQ treatment group rats were fed with high-glucose and high-fat diet for another 6 weeks. After that, TQ treatment group rats were administered TQ (5 mg/kg) by intraperitoneal injection every other day. The model group rats were injected with an equal dose of ethanol. Six weeks later, all the rats were sacrificed to obtain the hippocampal tissue for the protein extract. The protein levels of nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1) and cyclooxygenase 2 (COX-2) in the hippocampal tissue were measured by Western blot. Superoxide dismutase (SOD) activity was determined by SOD kit. Blood-glucose meter was used to assess the blood glucose before the rats were sacrificed and after the model was successfully established. All the measurement data was described by the x±s, measurement data were compared among groups using One Way ANOVA. Results The results by Western blots showed that the levels of the Nrf2 and HO-1 protein were significantly decreased in the model group compared with the normal control group, the levels of the Nrf2 and HO-1 proteins were increased in the TQ treatment group in comparison with the model group (P< 0.05).Meanwhile,compared with the normal control group, the SOD activity of the hippocampus in model group was significantly lower (P<0.05); by contrast with the model group, the SOD activity in the TQ treatment group was considerably increased (P<0.05). By contrast, the COX-2 level in the model group was substantially higher than that in the normal control (P<0.05), and the COX-2 level in the TQ treatment group was lower than that in the model group (P<0.05). Conclusions TQ might inhibit inflammation and improve oxidative stress of the brain tissue in the rats with type 2 diabetes mellitus. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Dalian University of Technology / Dalian Ligong Daxue Xuebao is the property of Journal of Dalian University of Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Jiangsu University (Natural Science Edition) / Jiangsu Daxue Xuebao (Ziran Kexue Ban) is the property of Editorial Department of Journal of Jiangsu University (Natural Science Edition) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Engineering Geology / Gongcheng Dizhi Xuebao is the property of Journal of Engineering Geology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Digital electronic technology experiment is one of the specialized courses for the student majoring in electronics or related. The arbitrary waveform generator based on DDS is used to the digital electronic technology comprehensive virtual simulation experiment. This teaching case covers almost all core knowledge in the theory of digital electronic technology course, and has characteristic of strong comprehensive. It is convenient for students to master theoretical knowledge fragmentation in the course to build into a relatively complete knowledge system. Experiment results such as sine wave, rectangular wave, triangle wave, arbitrary wave and Lissajous figures can be observed through the oscilloscope. The students ’ interests in learning are stimulated due to high presentation of experiment results. Practice shows that, comprehensive virtual simulation case can improve the students ? ability to design complex digital circuit system. It can also cultivate the students ’ ability of practical innovation and engineering application. It achieved good teaching effect, and was beneficial to the improvement of teaching level. [ABSTRACT FROM AUTHOR]

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Objective:To explore the prognosis of posttraumatic stress disorder (PTSD) in flood survivors 13 years after they had been diagnosed with PTSD symptoms, and investigate the relationship between their personality traits and the prognosis of PTSD. Method: In this cross-sectional study, the survivors of Dongting Lake flood in 1998 -1999 in Hunan in China, who were investigated and screened as PTSD symptoms positive in 2000 were se­lected as the target population, from which a sample of 200subjects was drawn using amulti-stage random sampling method The Posttraumatic Stress Disorder Scale Civilian Version (PCL-C) was used to examine and re-screen the participants of PTSD symptoms in order to explore the prognosis of PTSD. Participants whose PCL-C scores were equal to 44 or higher were classified as the PTSD symptoms positive group, while those with PCL-C scores less than 44 were classified as the recovered group. Personality traits were then assessed, using the Revised Eysenck Per­sonality Questionnaire Short Scale for Chinese (EPQ-RSC), in both the recovered group and the PTSD symptoms positive group. Finally, the multivariate logistic regression analysis was used to investigate the relationship between the prognosis of PTSD and personality traits. Results: Totally 200 subjects were eligible for this study and completed the questionnaires，but 16 of them had their questionnaires excluded from data analysis because they provided in- complete information‘ Thus，the response rate was 92‘ 0%• According to the PCL-C's cut-off score，22 participants were still screened as PTSD symptoms positive and were classified as the PTSD symptoms positive group, whereas the other 162 participants were screened as PTSD symptoms negative and were classified as the recovered group. Compared with the recovered group, the EPQ-RSC extroversion scores for the PTSD symptoms positive group were significantly lower [ (5L 8 ± 10. 7) vs. (45. 1 ± 13. 2), P <0. 05] and their neuroticism scores were sig- nificantly higher [(46‘5 ± 10‘ 1) vs‘（ 58‘3 ± 12‘2)，P <0‘05]. The multivariate logistic regression analysis showed, after adjusting for the variables such as gender and age, that higher neuroticism (OR =3. 63, 95% Cl: 1. 05 -12‘ 54) was a risk factor for the persistent PTSD symptoms in the flood survivors. Conclusions: It suggests that neuroticism is associated with prognosis of PTSD in flood survivors, those with higher neuroticism scores appear to have problems to recover from PTSD. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Jiangsu University (Natural Science Edition) / Jiangsu Daxue Xuebao (Ziran Kexue Ban) is the property of Editorial Department of Journal of Jiangsu University (Natural Science Edition) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Jiangsu University (Natural Science Edition) / Jiangsu Daxue Xuebao (Ziran Kexue Ban) is the property of Editorial Department of Journal of Jiangsu University (Natural Science Edition) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of China Sciencepaper is the property of China Sciencepaper and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Coal Science & Technology (0253-2336) is the property of Coal Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

In this paper，we use back propagation (BP) neural network，extreme learning machine (ELM)，regularized extreme learning machine (R-ELM) and DFT extreme learning machine (DFT-ELM) to realize the recognition of handwritten digital characters. Ten thousands handwritten digital samples from MINIST database are used to train neural network parameters in the process of data transmission，use the trained neural network parameters to do handwritten digital recognition test. In the light of the simulation results，BP has the best recognition accuracy， regardless of the training speed. Compared with ELM，although R-ELM and DFT-ELM have higher recognition accuracy，both of them increase the time complexity. This handwritten digital recognition simulation experiment can use to strengthen student's studying and understanding of neural networks and improve students' ability in programming and engineering application. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Dalian University of Technology / Dalian Ligong Daxue Xuebao is the property of Journal of Dalian University of Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Southwest China Journal of Agricultural Sciences is the property of Editorial Department of Southwest China Journal of Agricultural Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The formation seepage pressure in the construction of slurry shield tunnel is one of the main basis for setting construction parameters such as slurry pressure in the excavation chamber. In order to improve the accuracy of stratum seepage pressure calculation, the determination method and law of stratum seepage pressure of slurry shield tunnel were studied. Considering the construction elements such as soil excavation, slurry support and grouting behind the wall, a three-dimensional fluid-solid coupling model was established to simulate the dynamic process of slurry shield construction, the disturbance range and disturbance degree of shield construction and stratum conditions such as shield tunneling and synchronous grouting on stratum seepage pressure were analyzed. Based on this, a correction formula for stratum seepage pressure of slurry shield tunnel was proposed. The results show that when the grouting pressure is 200~500 kPa, the farthest influence range of shield tunneling on the formation penetration pressure is 4.5 rings away from the front of the excavation face; under the same grouting pressure, the disturbance range of the rock layer is the largest, the disturbance range of the sand layer is the second, and the disturbance range of the clay layer is the smallest; the calculated value of the stratum permeability pressure obtained by the correction formula is basically consistent with the measured value trend, which verifies the rationality of the correction formula. [ABSTRACT FROM AUTHOR]

【Objective】The study aimed to clone, and analyze the bioinformatics, expression patterns and tobacco genetic transformation of NnTOM1 gene in Lotus (Nelumbo nucifera), which would provide a foundation for further study on the function of NnTOM1 gene.【Method】NnTOM1 gene was obtained by cloning, and its protein physicochemical properties, and conserved domain etc. were analyzed using bioinformatics tools. The tissue-specific expression of NnTOM1 gene was analyzed by quantitative real-time polymerase chain reaction (qRT-PCR). The biological function of NnTOM1 gene was preliminarily verified by tobacco genetic transformation.【Result】The study revealed that the coding sequence (CDS) of NnTOM1 gene was 1191 bp, which encoded 396 amino acids, and the protein molecular formula was C1918H3130N560O589S16. The secondary structure of the protein was mainly composed of α-helix and random coil. It contained the TOM family conserved domains (VHS-ENTH-ANTH and GAT), which was localized in the cytoplasm. Multiple sequences comparison and phylogenetic tree analysis showed that NnTOM1 protein was closely related to Macadamia integrifolia, Telopea speciosissima and Macleaya cordata, and the sequence identity was high. The results of qRT-PCR showed that the expression of NnTOM1 gene was highest in petalized stamens and lowest in roots, moreover, it was higher in multiple-petal varieties than single-petal varieties. The phenotype of NnTOM1 positive transgenic plants showed that compared with the wild type, the color of the petals was deepened, the tip of the petals was pointed, the spacing of the petals was widen, and the filaments were longer and obviously longer than the style. The OE-1 strain with a phenotype of 6 petals had one more petal than the wild type.【Conclusion】The NnTOM1 gene in lotus might be involved in flower organs development. The study provided a preliminary basis for further study on the function of NnTOM1 gene, and provided a new gene resource for breeding of new lotus varieties. [ABSTRACT FROM AUTHOR]

BACKGROUND: Lumbar fixed-point rotation operation needs collaborative operation of the doctor’s hands, and outputs rotation and thumb thrust. Lumbar disc herniation can be treated through disc displacement and adjusting stress distribution. However, the mechanical effects of thumb thrust and the biomechanical effects of loading direction on manipulative effects remain unclear. OBJECTIVE: To compare the biomechanical difference of lumbar fixed-point rotation manipulation for treating lumbar disc herniation under different thrust directions. METHODS: The L3-5 normal three-dimensional finite element model was constructed and validity was verified. According to the intervertebral disc degeneration Pfirrmann grade, intervertebral disc degeneration was simulated by modifying the L4/5 intervertebral space height, the volume of the nucleus pulposus, as well as the material parameters of the annulus fibrosus, nucleus pulposus, and ligament. Finally, the pathological model of L4/5 moderate disc degeneration with left para-central herniation was constructed, and then the pathological models were used as research objects. Simulation technique: spinning to the right; taking the condition on changing the direction of the thumb thrust to establish three modes of operation (M1: thumb push to the left; M2: thumb push to the right; M3: no thrust push). The protrusion displacement and the disc stress, and the stress and strain of the facet joint cartilage were compared in the three operating modes. RESULTS AND CONCLUSION: (1) Maximum displacement value of L4/5 disc herniation: displacement was 2.672 3 mm for M1, 1.156 1 mm for M2, 1.826 4 mm for M3, M1 > M3 > M2. (2) The maximum Von Mises stress of L4/5 discs was 1.846 7 MPa for M1, 0.419 0 MPa for M2, and 1.257 9 MPa for M3, M1 > M3 > M2. (3) L4/5 bilateral small cartilage produced different degrees of contact stress changes: It was 0.485 5 MPa for M1, 0.026 7 MPa for M2, and 0.441 4 MPa for M3, M1 > M3 > M2. Right cartilage contact force was 0.000 5 MPa for M1, 0.025 9 MPa for M2, and 0.001 3 MPa for M3, M2 > M3 > M1; the left greater than the right, M1 had the highest value; cartilage strain was consistent with contact stress changes. (4) Different operation modes will have some biomechanical influences on the diseased intervertebral disc and accessory structure. The M1 operation mode can maximize the displacement of protrusion, disc stress and left joint cartilage contact, which can better promote disc displacement, balance stress distribution and reduce facet joint disorder, so the operation is better. [ABSTRACT FROM AUTHOR]

BACKGROUND: Previous studies have shown the correlation between lumbosacral sagittal plane parameters and natural absorption of lumbar disc herniation. However, the lumbosacral sagittal plane parameters included lumbar lordosis angle, lumbosacral joint angle, sacral inclination angle and many other parameters. The effects of each parameter on the natural absorption of the herniated disc were different. In addition, there are few studies on the reabsorption of a specific segment of intervertebral disc herniation at present, and most of the measured data are obtained from digital radiography or CT, while the correlation between lumbosacral sagittal plane parameters measured from MRI and reabsorption after L5/S1 intervertebral disc herniation is rarely reported. OBJECTIVE: To study the corresponding changes of lumbar sagittal plane parameters after L5/S1 intervertebral disc herniation reabsorption and to screen out the lumbosacral sagittal plane parameters with the most significant changes during intervertebral disc reabsorption. METHODS: Totally 57 patients with lumbar disc herniation who had complete MRI image data were selected and met the diagnostic criteria for lumbar disc herniation and only received non-surgical treatment for reabsorption of L5/S1 protrusion segments. MRI measured the protrusion area of the maximum protrusion plane in the coronal plane, lumbosacral sagittal plane parameters [lumbar curvature index, lumbar lordosis (α), L5/S1 disc angle (β), intervertebral height measurement, lumbosacral joint angle, sacral platform angle, sacral inclination angle, and lower lumbar lordosis angle]. Besides, lumbosacral sagittal plane parameters were ranked in the importance of variables by random forest model in R software, and then significant variables were fitted with multiple linear regression. The changes between parameters before and after treatment were analyzed and compared by paired sample t-test. RESULTS AND CONCLUSION: (1) A total of 57 patients with L5/S1 lumbar disc herniation were included in this study, and the symptoms and imaging features of the patients were significantly relieved to a large extent. (2) Before treatment, there were 4 cases of grade 1, 29 cases of grade 2 and 24 cases of grade 3 according to the Classification of Michigan State University. After treatment, there were 48 cases of grade 1 and 9 cases of grade 2. (3) The random forest model suggested that intervertebral height, lumbar curve index, sacral inclination angle, and lower lumbar lordosis angle changed significantly in L5/S1 disc herniation reabsorption, and the order of their change significance was lumbar curve index > intervertebral space height > sacral inclination angle > lower lumbar lordosis angle. (4) Lumbar curve index, lumbar lordosis and sacral platform angle increased, with statistical significance (P < 0.05). There were no significant differences in disc angle, intervertebral height, lower lumbar lordosis angle, sacral inclination angle or lumbosacral joint angle (P > 0.05). (5) Lumbar curvature index was the most significant parameter of the lumbosacral sagittal plane in herniated disc reabsorption. In addition, lumbar curve index, sacral inclination angle, and lower lumbar lordosis angle are commonly used clinically to describe the change of lumbar curvature, suggesting that L5/S1 disc herniation reabsorption is correlated with the change of lumbar curvature. It is indicated that in the treatment of lumbar disc herniation, a clinical cure can be achieved by improving or restoring the disordered lumbar curvature. [ABSTRACT FROM AUTHOR]

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目的探讨多种创新教学方法相结合在西医院校中医学教学中的效果。方法选取该校同一年级、同 一专业、同样学时及同一学期上课的2014级二本临床专业6个班的学生作为研究对象，将其随机分为教改组（136人）和 对照组（149人）2个大班进行教学。教改组采用视听教材+PPT、中西医对比法、以问题为基础的教学法、练习法及实物展 示法相结合的教学方法；对照组采用PPT课件加传统授课模式的教学方法。通过调查问卷、临床病例分析能力测验、期 末考试成绩比较两组的教学质量，分析、评价教改组的教学方法改革的实践运用效果。结果教改组学生对本门课产生 的兴趣明显高于对照组，且教改组满意度明显高于对照组，而对照组提出改进建议人数明显多于教改组，差异均有统 计学意义（P<0.05）。教改组在全对、病因病机分析、辨证分析、诊断、治则代表方的正确率上均明显高于对照组，差异均 有统计学意义（P<0.05）。教改组各分数段的期末考试成绩均明显多于对照组，差异均有统计学意义（P<0.05）。结论多 种创新教学方法相结合的教学方法，使学生积极参与教学，提高了学生综合素质，使教学质量显著提升。 [ABSTRACT FROM AUTHOR]

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