238 results on '"mucocutaneous"'
Search Results
202. Onkologische Therapien: Unerwünschte Wirkungen auf Haut und Haare
- Author
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Hallermann, C. and Schulze, H.-J.
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- 2007
- Full Text
- View/download PDF
203. Pemphigus vulgaris presenting as gingival involvement
- Author
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Heena Zainab and Mukhatar Ahmed Javali
- Subjects
Systemic disease ,Pathology ,medicine.medical_specialty ,mucocutaneous ,Mucocutaneous zone ,Case Report ,Disease ,Gingivitis ,medicine ,lcsh:Dermatology ,Desquamation ,integumentary system ,business.industry ,Pemphigus vulgaris ,Mucous membrane ,pemphigus ,lcsh:RL1-803 ,medicine.disease ,Dermatology ,Pemphigus ,stomatognathic diseases ,medicine.anatomical_structure ,medicine.symptom ,business ,Skin lesion ,gingivitis - Abstract
Pemphigus vulgaris (PV) is an autoimmune blistering disease affecting the mucous membrane and skin. Typically, oral lesions appear before skin lesions, and in a majority of the cases only oral lesions are present. The dentist may then be the first to recognize and diagnose this disease. It is unusual for PV to present over the gingiva as a primary site of involvement. Diagnosis is based on clinical presentation and confirmed by histopathological study. Early diagnosis and management can prevent the uneven life- threatening effects of this potentially chronic mucocutaneous disorder. The case serves to enhance our awareness of the gingiva as a site at which systemic disease can manifest itself.
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- 2012
204. Mucocutaneous manifestations in patients with rheumatoid arthritis: A cross-sectional study from Eastern India
- Author
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Ivoreen Darung, Surajit Biswas, Sudip Ghosh, and Debabrata Bandyopadhyay
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rheumatoid arthritis ,medicine.medical_specialty ,Mucocutaneous ,Mucocutaneous zone ,Rheumatoid nodule ,Dermatology ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Palmar erythema ,rheumatoid nodule ,lcsh:Dermatology ,medicine ,Rheumatoid factor ,030203 arthritis & rheumatology ,business.industry ,Incidence (epidemiology) ,lcsh:RL1-803 ,medicine.disease ,Surgery ,Rheumatoid arthritis ,Original Article ,medicine.symptom ,Panniculitis ,business ,Rheumatism - Abstract
Background: Cutaneous manifestations are fairly common in rheumatoid arthritis (RA) and they can help in early diagnosis, prompt treatment, and hence reduced morbidity from the disease. Aims: The objective of the present study was to find out the different patterns of dermatoses in a group of patients with RA from Eastern India. Methodology: Consecutive patients fulfilling the American Rheumatism Association 1987 revised criteria for the classification of RA and who had different dermatoses were included in this cross-sectional study done over a period of 8 years in a tertiary care hospital in Eastern India. Thorough clinical examination and appropriate laboratory investigations were performed as needed. Data were recorded in a predesigned schedule, and appropriate statistical analysis was done. Results: We studied 111 evaluable patients with an age range of 19–71 years and a female to male ratio of 7:1. The mean disease duration of RA was 6.5 years. Cutaneous infections as a group was the most common mucocutaneous manifestation (34.2%) followed by xerosis including ichthyotic skin changes (27%), pigmented purpuric dermatoses (14.4%), leg ulcer (9.9%), periungual telangiectasia (9.9%), rheumatoid nodules (RNs) (8.1%), purpura and ecchymoses (7.2%), small vessel vasculitis in (7.2%), corn and callosities (6.3%), palmar erythema (4.5%), and neutrophilic dermatosis (4.5%). Raynaud's phenomenon was found in 3.6% patients and panniculitis in (3.6%) patients. Rheumatoid factor (RF) and anti-cyclic citrullinated peptides antibody were positive in 74.8% and 88.3% patients, respectively. No statistically significant difference of incidence of leg ulcer, small vessel vasculitis, RN, or Raynaud's phenomenon could be noted between RF positive and negative groups. Limitations: Being an institution-based study, the study findings may not reflect the true situation in the community which remained a limitation of this study. Conclusion: While some of the features of this study were analogous to Western data, other features showed discordance which may be due to ethnic variations among the patients with RA.
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- 2017
205. Nasal angiomyolipoma: Report of two cases of an extremely rare entity
- Author
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P Kumudachalam, Ather Fatima, Ramya Priyadarshini, and Mohammed Abdul Aleem
- Subjects
Microbiology (medical) ,Nasal cavity ,medicine.medical_specialty ,Pathology ,Angiomyolipoma ,mucocutaneous ,Mucocutaneous zone ,lcsh:QR1-502 ,lcsh:Microbiology ,Pathology and Forensic Medicine ,Benign tumor ,03 medical and health sciences ,0302 clinical medicine ,Smooth muscle ,lcsh:Pathology ,medicine ,030223 otorhinolaryngology ,nasal angiomyolipoma ,business.industry ,Rare entity ,General Medicine ,Endoscopic excision ,nasal cavity ,medicine.disease ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Histopathology ,business ,lcsh:RB1-214 - Abstract
Nasal angiomyolipoma (AML) are extremely rare tumors and so far
- Published
- 2017
206. LeishMan Recommendations for Treatment of Cutaneous and Mucosal Leishmaniasis in Travelers, 2014
- Author
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Gundel Harms, Johannes Blum, Eric Caumes, Thomas P. C. Dorlo, Pierre Buffet, Gloria Morizot, Pieter P. A. M. van Thiel, Diana N. J. Lockwood, Jan Clerinx, Leo G. Visser, Mark S. Bailey, Christoph Hatz, Sub Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology, University of Zurich, and Blum, Johannes
- Subjects
Leishmaniasis, Mucocutaneous ,Pathology ,medicine.medical_specialty ,Mucocutaneous ,MEDLINE ,Antiprotozoal Agents ,Leishmaniasis, Cutaneous ,610 Medicine & health ,Global Health ,Disease Outbreaks ,Cutaneous leishmaniasis ,medicine ,Global health ,Humans ,Mucosal leishmaniasis ,Leishmaniasis ,Miltefosine ,Travel ,biology ,business.industry ,10060 Epidemiology, Biostatistics and Prevention Institute (EBPI) ,2739 Public Health, Environmental and Occupational Health ,2725 Infectious Diseases ,General Medicine ,medicine.disease ,Leishmania ,biology.organism_classification ,Cutaneous ,Family medicine ,Practice Guidelines as Topic ,business ,Leishmania DNA ,medicine.drug - Abstract
BACKGROUND: Treatment of cutaneous leishmaniasis (CL) and mucosal leishmaniasis (ML) in travelers is still controversial. Over the last decade, national and international consortia have published recommendations for treating CL in travelers. These guidelines harmonize many issues, but there are some discrepancies. METHODS: Leishmania parasites causing CL can now be genotyped by polymerase chain reaction techniques for detecting Leishmania DNA. Therefore, treatment recommendations can now be species based rather than based on geographical exposure. To review the evidence on which the recommendations were based, "LeishMan" (Leishmaniasis Management), a group of experts from 13 institutions in eight European countries, performed a PubMed MEDLINE) literature search and considered unpublished evidence and the experts' own personal experiences. The Oxford evidence grading system was used to evaluate the information. RESULTS AND CONCLUSION: In this article, the authors provide practical treatment recommendations for imported CL and ML in Europe, drawn up from the review by the European experts.
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- 2014
207. Mucocutaneous leishmaniasis as presentation of HIV infection in Sardinia, insular Italy
- Author
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Maria Laura Fiori, C Lovigu, Maria Stella Anna Mura, Francesco Riu, Ivana Maida, Giordano Madeddu, Sergio Babudieri, Pasquale Ena, Paola Bagella, and Giuseppe Nunnari
- Subjects
Leishmaniasis, Mucocutaneous ,Adult ,Male ,medicine.medical_specialty ,Mucocutaneous ,Human immunodeficiency virus (HIV) ,HIV Infections ,medicine.disease_cause ,Serology ,medicine ,Humans ,Leishmaniasis ,biology ,business.industry ,HIV ,Mucocutaneous leishmaniasis ,medicine.disease ,Leishmania ,biology.organism_classification ,Dermatology ,Infectious Diseases ,Italy ,Clinical diagnosis ,Immunology ,Parasitology ,Presentation (obstetrics) ,Mediterranean Islands ,business - Abstract
Leishmaniasis is endemic in Sardinia but only cutaneous and visceral cases have been reported to date. We report a case of mucocutaneous leishmaniasis as presentation of HIV infection in a Sardinian patient who had never visited endemic areas. Serological and clinical diagnosis was cytologically and histopathologically confirmed. The patient had a good response to treatment with liposomal amphotericin combined with highly active antiretroviral therapy without recurrences after four years. Our case report highlights the need to better assess the circulation of species, risk factors and clinical spectrum of Leishmania infection in the Italian Mediterranean islands.
- Published
- 2014
208. Mucocutaneous changes in tuberous sclerosis complex: A clinical profile of 27 Indian patients
- Author
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Sharmila Sarkar, Arghyaprasun Ghosh, Debabrata Bandyopadhyay, Gobinda Chatterjee, Sudip Ghosh, and Somenath Sarkar
- Subjects
medicine.medical_specialty ,Pathology ,mucocutaneous ,business.industry ,shagreen patch ,Mucocutaneous zone ,Tuberous sclerosis ,Dermatology ,lcsh:RL1-803 ,medicine.disease ,Hypomelanotic macule ,medicine.anatomical_structure ,Scalp ,medicine ,Forehead ,lcsh:Dermatology ,Original Article ,medicine.symptom ,Family history ,business ,adenoma sebaceum ,Adenoma sebaceum ,Connective tissue nevus - Abstract
Background: Tuberous sclerosis complex (TSC) is an autosomal dominant neurocutaneous disease resulting in a wide array of clinical manifestations, primarily affecting the skin and central nervous system. Mucocutaneous features play a very important role in the recognition of this syndrome. Aims: To review the prevalence and patterns of cutaneous manifestations in tuberous sclerosis, in a group of patients from eastern India. Methods: Observational clinical study on twenty-seven consecutive patients of tuberous sclerosis collected during a period of four years. Results: Most were between 10-20 years of age; the male to female ratio was 2:1. Family history was found in two-thirds. The classical triad of tuberous sclerosis was present in only nine (33.3%) patients. Adenoma sebaceum was the most common cutaneous feature (100%), followed by hypomelanotic macules (92.6%), connective tissue nevi (66.6%), and Koenen′s tumors (33.3%). Oral mucosal fibromas were seen in six (22.22%) patients. Fibromatous plaque over forehead and scalp was seen in three patients. Limitation of the study was small size of study sample. Conclusion: Prominent mucocutaneous changes are extremely common manifestation of TSC, which may provide crucial diagnostic clues for primary care physicians.
- Published
- 2009
209. Case of Incomplete Kawasaki Disease with No Symptoms Except Fever Causing the Development of Coronary Aneurysm.
- Author
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Uchida Y, Iwamoto Y, Urushihara Y, Nagura M, Tanaka R, Arakawa H, Ishido H, Moriwaki K, and Masutani S
- Subjects
- Asymptomatic Diseases, Coronary Aneurysm diagnosis, Coronary Angiography, Diagnosis, Differential, Echocardiography, Humans, Infant, Male, Coronary Aneurysm etiology, Coronary Vessels diagnostic imaging, Fever complications, Mucocutaneous Lymph Node Syndrome complications
- Abstract
Incomplete Kawasaki disease (iKD), which does not satisfy the standard KD diagnostic criteria because the required number of principal symptoms is not met, sometimes causes coronary aneurysms. Here we report the case of a patient with iKD who presented with only one principal symptom that resulted in the development of coronary aneurysm, as evidenced by angiography.
- Published
- 2019
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210. A Rare Case of Intraoral Psoriasis.
- Author
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Venugopal DC, S S, and Narasimhan M
- Abstract
Psoriasis is a chronic inflammatory mucocutaneous disease predominantly affecting the skin. While oral manifestations are common in many papulosquamous conditions, the occurrence of oral lesions in psoriasis is relatively rare. This case report highlights the presence of oral lesions in cutaneous psoriasis and the need for early identification of such lesions for timely management and better symptomatic improvement., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2019, Venugopal et al.)
- Published
- 2019
- Full Text
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211. Orofacial manifestations of mucocutaneous leishmaniasis: a case series from Brazil.
- Author
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Falcão GGVSC, Lins-Kusterer L, Leite-Ribeiro PM, and Sarmento VA
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- Adult, Biopsy, Brazil, Child, Diagnosis, Differential, Female, Humans, Male, Middle Aged, Skin parasitology, Young Adult, Face pathology, Leishmaniasis, Mucocutaneous diagnosis, Mouth Diseases parasitology
- Abstract
Dentists play a fundamental role in the early diagnosis of oral leishmaniasis. Although these lesions are rare at oral mucosa, this is one of the manifestations sites of the disease This study reports seven clinical cases of orofacial mucocutaneous leishmaniasis. All had leishmaniasis diagnosis confirmed by laboratory tests, with orofacial involvement. Five out of the seven cases were males, and in four cases, patients had associated comorbidities. Late diagnosis was observed, resulting in treatment delay and increased hospitalization stay. One patient had severe psychological consequences due to facial deformity. The lack of differential diagnosis due the great variability of clinical presentation of the lesions and frequent unspecific histopathology represent a challenge for the dentist. In two reported cases, there were unspecific biopsy results. This series of cases highlights the importance of a multidisciplinary approach in the diagnosis and treatment of oral and perioral leishmaniasis. Patients with atypical lesions, originating from or living in endemic regions, should be investigated for leishmaniasis. These procedures could avoid delays in diagnosis and decrease the risk of disease dissemination., Competing Interests: No competing interests were disclosed., (Copyright: © 2020 Falcão GGVSC et al.)
- Published
- 2019
- Full Text
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212. Primary classic Hodgkin lymphoma of the ileum and Epstein-Barr virus mucocutaneous ulcer of the colon: two entities compared.
- Author
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Zanelli M, Mengoli MC, Valli R, Froio E, Bisagni A, Zizzo M, De Marco L, and Ascani S
- Subjects
- Adult, Aged, 80 and over, Biomarkers, Tumor analysis, Biopsy, Colonic Diseases immunology, Colonic Diseases virology, Diagnosis, Differential, Epstein-Barr Virus Infections immunology, Epstein-Barr Virus Infections virology, Female, Hodgkin Disease drug therapy, Hodgkin Disease metabolism, Humans, Ileal Neoplasms chemistry, Ileal Neoplasms drug therapy, Immunocompromised Host, Immunohistochemistry, Immunosuppressive Agents adverse effects, Male, Methotrexate adverse effects, Opportunistic Infections immunology, Opportunistic Infections virology, Predictive Value of Tests, Ulcer immunology, Ulcer virology, Colonic Diseases pathology, Epstein-Barr Virus Infections pathology, Hodgkin Disease pathology, Ileal Neoplasms pathology, Opportunistic Infections pathology, Ulcer pathology
- Abstract
Primary classic Hodgkin lymphoma of the gastrointestinal tract represents a rare occurrence. A full patient's work-up is essential in order to exclude a secondary intestinal involvement. Histologically Epstein-Barr virus mucocutaneous ulcer closely resembles Hodgkin lymphoma. The differential diagnosis between these two entities is relevant, since both the therapeutic approach and the clinical behavior are different. Herein, we describe a case of primary classic Hodgkin lymphoma arising in the ileum and a case of Epstein-Barr virus mucocutaneous ulcer of the colon, focusing on the main clinicopathological differences.
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- 2019
- Full Text
- View/download PDF
213. Metolazone Induced Stevens Johnson Syndrome (SJS).
- Author
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Rasheed, Aamil, Acharya, Sourya, and Bhagwati, Jahanbi
- Subjects
- *
STEVENS-Johnson Syndrome , *DRUG side effects , *ALLOPURINOL , *CARBAMAZEPINE - Abstract
Stevens Johnson Syndrome (SJS) is characterized by hemorrhagic erosions, erythema and often presents as blisters and detachment of the epidermis because of necrosis. It is a Type IV Hypersensitivity reaction secondary to medication or infection. drugs like Allopurinol, Carbamazepine, Aminopenicillins, Oxicam-type of NSAIDS etc. are at high risk of causing Stevens-Johnson Syndrome. Metolazone is a long acting thiazide like diuretic. It potentiates the action of Furesomide. Metolazone Induced SJS is rarely reported. We report a rare case of Metolazone induced SJS in a 58-year-old male patient. [ABSTRACT FROM AUTHOR]
- Published
- 2018
214. American tegumentary leishmaniasis: correlations among immunological, histopathological and clinical parameters
- Author
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Ana Claudia Grizzo Peres Martins, José Roberto Pereira Lauris, Ana Luiza Grizzo Peres Martins, and Jaison Antônio Barreto
- Subjects
Adult ,Male ,medicine.medical_specialty ,Pathology ,Delayed Diagnosis ,Time Factors ,Adolescent ,mucocutaneous ,Biopsy ,Adaptive immunity ,Leishmaniasis, Cutaneous ,Disease ,Dermatology ,Parasite load ,Asymptomatic ,Severity of Illness Index ,Statistics, Nonparametric ,Serology ,Lesion ,Young Adult ,Epidemiology ,medicine ,Humans ,Child ,Pathological ,Leishmaniasis ,Aged ,Retrospective Studies ,Skin ,Investigation ,Granuloma ,Hyperplasia ,business.industry ,Age Factors ,Epidemiologic factors ,Retrospective cohort study ,Middle Aged ,Cross-Sectional Studies ,RL1-803 ,Female ,medicine.symptom ,business - Abstract
BACKGROUND: American tegumentary leishmaniasis has an annual incidence of 1 to 1.5 million cases. In some cases, the patient's immune response can eliminate the parasite, and the lesion spontaneously resolves. However, when this does not occur, patients develop the disseminated form of the disease. OBJECTIVE: To investigate the association between clinical, laboratory and pathological findings in cases of American tegumentary leishmaniasis. METHODS: A retrospective study of the medical records of 47 patients with American cutaneous leishmaniasis. Clinical, laboratory and epidemiological data were collected, and semi-quantitative histopathological analyses were performed using the Spearman correlation coefficient (p
- Published
- 2012
215. Accurate and rapid species typing from cutaneous and mucocutaneous leishmaniasis lesions of the New World
- Author
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Nicolas Veland, Braulio M. Valencia, Gert Van der Auwera, Alejandro Llanos-Cuentas, Nicolas Praet, Jean-Claude Dujardin, Jorge Fraga, Ana Margarita Montalvo, Andrea K. Boggild, and Jorge Arevalo
- Subjects
Pathology ,Skin Leishmaniasis ,Identification ,Mucocutaneous ,America, Latin ,Protozoan Proteins ,Polymerase Chain Reaction ,law.invention ,Hsp70 ,PCR-RFLP ,Sensitivity ,law ,Peru ,Leishmania guyanensis ,Leishmaniasis ,Polymerase chain reaction ,Accuracy ,Allele ,Leishmania ,hsp70 ,General Medicine ,Protozoal diseases ,Vectors ,Skin Biopsy ,Detection ,Infectious Diseases ,Restriction fragment length polymorphism ,Leishmaniasis Cutaneous ,Diagnostic Value ,Restriction Fragment Length Polymorphism ,Microbiology (medical) ,medicine.medical_specialty ,Heat Shock Protein 70 ,Genotype ,Limit Of Detection ,Mucocutaneous zone ,Leishmaniasis, Cutaneous ,Biology ,purl.org/pe-repo/ocde/ford#3.03.08 [https] ,Leishmania Peruviana ,Leishmania braziliensis ,Sandflies ,parasitic diseases ,medicine ,Humans ,HSP70 Heat-Shock Proteins ,Typing ,Alleles ,Leishmania peruviana ,Species ,Genus ,Laboratory techniques and procedures ,medicine.disease ,biology.organism_classification ,Virology ,Controlled Study|Genotype ,Cutaneous ,Phlebotomus argentipes ,Intermethod Comparison ,Species Identification ,Heat-shock proteins ,Human medicine ,Leishmania Braziliensis ,Sensitivity And Specificity - Abstract
The heat-shock protein 70 gene (hsp70) has been exploited for Leishmania species identification in the Old and New World, using polymerase chain reaction (PCR) followed by restriction fragment length polymorphism analysis. Three new Leishmania-specific hsp70 PCRs were recently described, and we applied 2 of these on 89 clinical samples from a total of 73 Peruvian patients with either cutaneous or mucocutaneous leishmaniasis. The new PCRs on average showed a 2- to 3-fold improved sensitivity in the tested sample types (lesion biopsies, aspirates, and scrapings), for both genus detection and species typing, and were most successful in biopsies. Leishmania braziliensis, L. peruviana, and L. guyanensis were encountered. About one third of the L braziliensis parasites contained 2 hsp70 alleles. This study is a paradigm for the implementation of a globally applicable upgraded tool for the identification of Leishmania directly on human specimens from cutaneous and mucocutaneous lesions in the New World. (C) 2012 Elsevier Inc. All rights reserved.
- Published
- 2012
216. Leishmaniasis mucosa: consideraciones epidemiológicas y de tratamiento
- Author
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Nunes, Caroline Sampaio Alves, Yoshizawa, Juliano Kazuo, Oliveira, Rosangela Ziggiotti de, Lima, Airton Pereira de, Oliveira, Letícia Ziggiotti de, and Lima, Meiri Vanderlei Nogueira de
- Subjects
Membrana Mucosa ,Mucous Membrane ,mucocutaneous ,Leishmaniasis mucocutánea ,Leishmaniose Mucocutânea ,Leishmaniose ,Leishmaniasis - Abstract
In South Brazil, American tegumentary leishmaniasis is predominant at Paraná, specially on the North and West areas, where it is localized one of the disease’s production circuits. It is believed that 3 to 5% of the cases evolve to the mucosal form, and that 1% of these can evolve to death. There is a long time that first choice drugs to treat this disease are the antimony compounds as pentavalent salts. The purpose of this study was to describe epidemiological and treatment characteristics of patients with mucosal leishmaniasis, who were diagnosed during the period from 2001 to 2007 in cities located on the coverage area of the 13 Heath Regional, which is situated in Cianorte, Paraná. The data were collected at the outpatient medical records and the System of Notifications and Information of Diseases epidemiological investigation records. During the mentioned period, 505 cases of American tegumentary leishmaniasis were notified, 30 of them (6%) as the mucosal form. In this study, the patients included were those with diagnosis of mucosal leishmaniasis that had complementary exams performed before and during the treatment. The results showed the need of patients’ careful monitoring by health teams, due to the possible evolution of the disease and the presence of unwanted drug effects. En la región Sur de Brasil, la leishmaniasis tegumentaria americana predomina en el estado de Paraná, principalmente al Norte y Oeste del país, donde está localizado uno de los circuitos de producción de la enfermedad. Se estima que de 3 a 5% de los casos de leishmaniasis cutánea desenvuelvan lesión mucosa, y que cerca de 1% de ellas puedan acabar en muerte. Por mucho tiempo, las drogas escogidas para tratar la enfermedad son los compuestos antimoniales bajo la forma de sales pentavalentes. El objetivo de este estudio fue describir características epidemiológicas y de tratamiento de los pacientes con leishmaniasis mucosa, diagnosticados en el periodo de 2001 a 2007, en municipios localizados en el área de estudio de la 13ª Regional de la Salud, localizada en el municipio de Cianorte, Paraná. Las informaciones fueron colectadas del registro médico y de los papeles de investigación epidemiológicos del SINAN (Sistema de Notificación e Información de Agravios). En el periodo estudiado, fueron notificados 505 casos de leishmaniasis tegumentaria americana, 30 de los cuales (6%) en forma mucosa. Fueron incluidos en el estudio pacientes diagnosticados con leishmaniasis mucosa, que poseían exámenes complementares realizados antes y durante el tratamiento. Los resultados evidenciaron la necesidad de cuidadosamente acompañar los enfermos en los equipos de salud, dada la posible evolución y la presencia de efectos medicamentosos indeseables en los pacientes afectados por la condición. Na região Sul do Brasil, a leishmaniose tegumentar americana predomina no Estado do Paraná, especialmente ao Norte e Oeste, onde um dos circuitos de produção da doença é localizado. Estima-se que 3 a 5% dos casos de leishmaniose cutânea desenvolvam lesão mucosa, e que cerca de 1% destas podem evoluir para óbito. De longa data, as drogas de escolha para tratamento da doença são os compostos antimoniais sob a forma de sais pentavalentes. O objetivo deste estudo foi descrever características epidemiológicas e de tratamento dos pacientes com leishmaniose mucosa, diagnosticados no período de 2001 a 2007, em municípios localizados na área de abrangência da 13ª Regional de Saúde, com sede no município de Cianorte, no Paraná. As informações foram coletadas do prontuário ambulatorial e das fichas de investigação epidemiológicas do Sistema de Notificação e Informação de Agravos. No período estudado, foram notificados 505 casos de leishmaniose tegumentar americana, 30 deles (6%) na forma mucosa. Foram incluídos no estudo pacientes com diagnóstico de leishmaniose mucosa, que apresentavam exames complementares realizados antes e durante o tratamento. Os resultados evidenciaram a necessidade de acompanhamento cuidadoso dos doentes nas equipes de saúde, dado a possível evolução e presença de efeitos medicamentosos indesejáveis nos pacientes afetados pela condição.
- Published
- 2011
217. Mucocutaneous manifestations in children with human immunodeficiency virus infection
- Author
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Vibhu Mendiratta, Saurabh Mittal, Ram Chander, and Arpita Jain
- Subjects
medicine.medical_specialty ,mucocutaneous ,Mucocutaneous zone ,Human immunodeficiency virus (HIV) ,India ,Dermatology ,medicine.disease_cause ,Pathogenesis ,Acquired immunodeficiency syndrome (AIDS) ,Epidemiology ,lcsh:Dermatology ,Medicine ,Dermatomycoses ,Humans ,Disease process ,Child ,Children ,Immune status ,human immunodeficiency virus ,AIDS-Related Opportunistic Infections ,business.industry ,Transmission (medicine) ,Incidence ,Candidiasis, Chronic Mucocutaneous ,virus diseases ,Bacterial Infections ,lcsh:RL1-803 ,medicine.disease ,Prognosis ,Infectious Diseases ,Immunology ,business - Abstract
Skin is one of the most frequently involved organs in human immunodeficiency virus (HIV) infection, and mucocutaneous manifestations may be one of the earliest markers of AIDS. The prevalence of cutaneous abnormalities in HIV approaches nearly 90%. Mucocutaneous manifestations may also act as a prognostic marker of HIV infection. Children are increasingly being affected by HIV infection and it is important to realize the presence of the infection early in the disease process as their immune status is not mature enough to handle the stress of various infections. Skin manifestations can serve as early markers and prognostic indicators of HIV infection. This review highlights the epidemiology, transmission, pathogenesis, and the mucocutaneous manifestations of HIV infection in children.
- Published
- 2010
218. Mucocutaneous manifestations of Dengue fever
- Author
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Bimal Kanish, Mary John, and Emy Abi Thomas
- Subjects
Erythema ,mucocutaneous ,business.industry ,Mucocutaneous zone ,Dermatology ,rash ,lcsh:RL1-803 ,medicine.disease ,Dengue fever ,Viral infection ,Rash ,Morbilliform ,Immunology ,lcsh:Dermatology ,medicine ,Drug rash ,IJD Symposium ,medicine.symptom ,Differential diagnosis ,business - Abstract
Dengue viral infection is a cause of considerable morbidity and mortality and may be associated with a variety of mucocutaneous manifestations that may provide important early clues to the diagnosis of this condition. Cutaneous and mucosal findings like confluent erythema, morbilliform eruptions, and hemorrhagic lesions may figure prominently in the clinical features of dengue. The differential diagnoses include a large number of bacterial and viral exanthems as well as drug rash.
- Published
- 2010
219. Mucocutaneous manifestations of Chikungunya fever
- Author
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Debabrata, Bandyopadhyay and Sudip Kumar, Ghosh
- Subjects
mucocutaneous ,treatment ,IJD Symposium ,Chikungunya - Abstract
Chikungunya fever (CF) is an arboviral acute febrile illness transmitted by the bite of infected Aedes mosquitoes. After a quiescence of more than three decades, CF has recently re-emerged as a major public health problem of global scale. CF is characterized by an acute onset of high fever associated with a severe disabling arthritis often accompanied by prominent mucocutaneous manifestations. The disease is usually self-limiting, but the joint symptoms and some of the cutaneous features may persist after the defervescence. A wide range of mucocutaneous changes has been described to occur in association with CF during the current epidemic. Besides a morbilliform erythema, hyperpigmentation, xerosis, excoriated papules, aphthous-like ulcers, vesiculobullous and lichenoid eruptions, and exacerbation of pre-existing or quiescent dermatoses had been observed frequently. These unusual features may help in the clinical differential diagnosis of acute viral exanthems mimicking CF.
- Published
- 2010
220. Complicación mucosa de la leishmaniasis cutánea
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Martín Prager, Maria Consuelo Miranda, Diego Fernando Zea, and Roger Figueroa
- Subjects
medicine.medical_specialty ,lcsh:Arctic medicine. Tropical medicine ,mucocutaneous ,lcsh:RC955-962 ,polymerase chain reaction ,030231 tropical medicine ,lcsh:Medicine ,leishmaniasis/therapy ,General Biochemistry, Genetics and Molecular Biology ,Disease course ,03 medical and health sciences ,0302 clinical medicine ,Cutaneous leishmaniasis ,medicine ,leishmaniasis ,Gynecology ,cutaneous, leishmaniasis ,0303 health sciences ,Medical treatment ,030306 microbiology ,business.industry ,lcsh:R ,Leishmaniasis ,medicine.disease ,3. Good health ,Surgery ,leishmaniasis/diagnosis ,business - Abstract
Se presenta el caso de un hombre de 74 anos procedente del area rural de Caicedonia, Valle del Cauca, con diagnosticos de hipertension arterial no controlada, insuficiencia renal cronica estadio IV y anemia grave. Tenia antecedentes de leishmaniasis cutanea en los parpados del ojo derecho, el pabellon auricular izquierdo y las extremidades, diagnosticada 15 anos atras en el departamento del Guaviare. Recibio tratamiento incompleto con antimoniales en esa epoca. Consulto al Centro Internacional de Entrenamiento e Investigaciones Medicas (CIDEIM) por un cuadro progresivo de ocho anos de evolucion de lesiones mucosas ulceradas en el labio superior, la mucosa nasal y los parpados del ojo derecho (figura 1). Se hizo un diagnostico histopatologico de leishmaniasis, confirmado mediante reaccion en cadena de la polimerasa (figura 2). Debido a las enfermedades concomitantes del paciente, el tratamiento con antimoniales (Glucantime®) estaba contraindicado. Se administro tratamiento supervisado intrahospitalario con miltefosine (Impavido®, capsulas de 50 mg) a una dosis diaria de 1,8 mg/kg por 28 dias, de acuerdo con las guias nacionales. Se realizo control clinico y de laboratorio durante el tratamiento y despues de finalizado, sin evidencia de ningun tipo de complicacion. El paciente asistio a controles medicos hasta la octava semana despues del tratamiento, en los cuales presento mejoria clinica de las lesiones (figura 3). Se remitio para continuar el manejo complementario por medicina interna, oftalmologia y cirugia plastica. La leishmaniasis mucocutanea es una grave complicacion evitable de la leishmaniasis cutanea. Este caso muestra fallas en el diagnostico y tratamiento oportunos y, en general, en el programa de control de esta enfermedad. Por otra parte, el miltefosine surge como una opcion terapeutica a los antimoniales para el tratamiento de pacientes en quienes esten contraindicados o presenten alto riesgo de toxicidad.
- Published
- 2009
221. Mucocutaneous Bean syndrome: Review of literature and case report
- Author
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Sunil Sukumaran Nair and Devi Gopakumar
- Subjects
lcsh:Medical physics. Medical radiology. Nuclear medicine ,Angiomatosis ,Pathology ,medicine.medical_specialty ,mucocutaneous ,Anemia ,lcsh:R895-920 ,Mucocutaneous zone ,Asymptomatic ,Lesion ,Pathognomonic ,medicine ,Radiology, Nuclear Medicine and imaging ,General Dentistry ,business.industry ,syndrome ,medicine.disease ,bleb ,lcsh:RK1-715 ,Otorhinolaryngology ,lcsh:Dentistry ,Vascular channel ,medicine.symptom ,Bleb (medicine) ,business - Abstract
Bean syndrome or blue rubber bleb syndrome is a rare disorder of vascular channels with mucocutaneous manifestations. The clinical severity varies among patients from being totally symptom free to fatal bleeding resulting in anemia. As the histopathologic findings are not pathognomonic, diagnosis is usually made from the clinical presentation, though the imaging techniques reveal extension of the lesion. We report an asymptomatic case of blue rubber bleb syndrome who reported for dental treatment with oral and cutaneous manifestations.
- Published
- 2015
222. An Atypical Presentation of Disseminated Mucocutaneous Leishmaniasis Caused by Leishmania major In Iran.
- Author
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Normohamadpur P and Ghaedi F
- Abstract
Although leishmaniasis is an endemic disease in Iran the mucosal involvement is rare. Mucocutaneous leishmaniasis (MCL) mainly caused by Leishmanial braziliensis infection, reported with other Leishmania species such as L. major . Herein a 78 yr old man with MCL from Iran is presented who referred to Razi Hospital Dermatology Clinic, Tehran, Iran, for multiple ulcerative lesions on mid face skin, mucosa of upper lip and anterior fossa of nose, dorsal aspect of the hands and the posterior aspect of heels. Skin biopsy revealed necrotizing and granulomatous tissue pattern that suggested infection pathogenesis but the smear for leishmaniasis, Mycobacterium spp, and fungal elements was negative at first. In order to a positive PPD test, he was treated by anti-tuberculosis treatment. A month after starting drugs for tuberculosis, the prepared microscopical smears were positive for Leishman bodies this time. The skin biopsy revealed amastigote forms of Leishmania sp. and the PCR assay on specimens of lesions proved L. major as the principal pathogenic agent. There was good response to systemic treatment with meglumine antimoniate (Glucantime®) 3 gr per day until one week followed by 4.5 gr per day for another week. We forced to discontinue of drug because of cardiac toxicity at the end of 2
nd wk of treatment., Competing Interests: Conflict of interest The authors declare that there is no conflict of interest.- Published
- 2018
223. Accidentality from Mucocutaneous Exposure to Biological Fluids Among Clinical Laboratory Professionals
- Author
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Panunzio, Amelia Patricia, Núñez Barboza, Milagros, Fuentes, Belkis, Parra, Irene, Sirit, Yadira, Villarroel, Francis, Velasco, Doris, García, Lenis, Panunzio, Amelia Patricia, Núñez Barboza, Milagros, Fuentes, Belkis, Parra, Irene, Sirit, Yadira, Villarroel, Francis, Velasco, Doris, and García, Lenis
- Abstract
Occupational exposure to biological fluids through mucocutaneous contact and related factors was determined through a descriptive study using a sample of 156 medical technicians working in public clinical laboratories in the metropolitan area of Zulia. A survey for data collection was designed which explored exposure and related factors such as compliance with post biological exposure measures. The age average of the bioanalysts was 41.9± 9.7; 87.2% were female. Results evidenced occupational exposure through mucocutaneous accidents, with a prevalence rate of 172.6 accidents for every 100 workers, represented primarily by splashes 44.3% and spray 32.7%, detected at amoderate level involving female workers with age ranges 54-60 and 26-32, 1-8 years on the job, during day shifts. Biological accidentality according to associate factors showed moderate exposure levels for all the biological fluids investigated in small volumes, at the level of the ocular mucosa, in sample processing and waste disposal areas. A medium compliance level was recorded for post-exposure handling, with a statistically significant difference (p>0.01) among the measures investigated. The magnitude and characteristics of exposure to biological fluids poses a problem that could impact personnel health, and it should be addressed institutionally to achieve effective prevention and risk control management., Se determinó la exposición laboral accidental a fluidos biológicos por contacto muco-cutáneo y factores asociados, mediante un estudio descriptivo dirigido a una muestra de 156 bioanalistas adscritos a laboratorios clínicos públicos del área metropolitana del estado Zulia. Para la recolección de datos se diseñó un instrumento que explora la exposición y factores vinculados así como el cumplimiento de medidas post exposición biológica. El promedio de edad de los Bioanalistas fue de 41.9 Ó 9.7 años con predominio del sexo femenino 87,2%. Se evidencia exposición por accidentes muco-cutáneos con una tasa de prevalencia de 176,2 accidentes por cada 100 trabajadores, representados principalmente por salpicaduras 44,3% y spray 32,7% detectados en razón de su ocurrencia en un nivel de exposición moderado, en las edades , 54-60 y 26-32 años, en sexo femenino, entre 1-8 años de antigüedad, durante la jornada diurna. La accidentabilidad en relación a los factores asociados, se registra en un nivel de exposición moderado, con todos los fluidos biológicos indagados, en pequeño volumen, a nivel de mucosa ocular, en áreas de procesamiento de muestras y disposición de desechos en el laboratorio. Un nivel de mediano cumplimiento se obtuvo para el manejo post exposición identificándose diferencia estadísticamente significativa entre las medidas indagadas (p> 0.01). La magnitud y características de la exposición a fluidos biológicos revisten una problemática que puede impactar en la salud del personal y debe ser abordada institucionalmente para una efectiva gestión de prevención y control de riesgo.
- Published
- 2008
224. La Leishmaniasis Tegumentaria en el Alto Tambopata, Departamento de Puno, Perú
- Author
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Arístides Herrer
- Subjects
lcsh:R5-920 ,Perú ,Leishmaniasis mucocutánea, Perú ,mucocutaneous ,mucocutánea ,lcsh:R ,Peru ,lcsh:Medicine ,lcsh:Medicine (General) ,Leishmaniasis - Abstract
Se relatan los estudios ecológico-epidemiológicos realizados en 1975 en la parte alta del valle de Tambopata (Alto Tambopata), en relación con la leishmaniasis tegumentaria o espundia y con la esperanza de que los resultados de esta investigación puedan posteriormente orientar campañas preventivas contra la espundia. Se practicó la inoculación intradérmica del antígeno leishmanina, la reacción de Montenegro en un total de 556 personas, obteniéndose 116 casos positivos. Se relacionó la intensidad de la reacción con las localidades donde se practicó la reacción de Montenegro. Se realizó la búsqueda de infección leishmaniásica en mamíferos selváticos que fueron capturados y en los mamíferos domésticos de la zona, de los cuales tres perros, una mula y un asno tenían lesiones cutáneas comparables a las que da lugar la leishmaniasis tegumentaria en la especie humana. En los cultivos realizados a partir de las lesiones cutáneas en ocho casos humanos de leishmaniasis tegumentaria se obtuvo en cuatro de ellos el aislamiento del agente etiológico de la espundia. A partir de los estudios entomológicos se recolectó en conjunto 868 especímenes de titiras, correspondiente a nueve especies del género Lutzomyia; L. auraensis representó 79,8% del total de titiras capturadas y L. migoni el 12,0%. Tanto por la ocurrencia de las lesiones metastásicas en las mucosas buco- naso-faríngeas, así como por la presencia de personas con reacción de Montenegro positiva y sin evidenciar infección leishmaniásica en el Alto Tambopata, presente o pasada, ésta no difiere de las que ocurren en otros países sudamericanos, donde la espundia es endémica. Ecological and epidemiological studies performed in the highlands of the Tambopata Valley (High Tambopata) during 1975, about "espundia" or tegumentary Leishmaniasis are hereby described, hoping that the findings of this research could be useful to guide preventive actions against "espundia". The intradermical inoculation of the leishmanina antigen, Montenegro reaction was used in 556 humans, and 116 positive cases were found. The intensity of the reaction was related to the sites where the Montenegro reaction was performed. Leishmania infection was sought in jungle mammals that were captured, as well as in domestic mammals living in the area; of these, three dogs, one mule and one donkey had cutaneous injuries, resembling those of tegumentary leishmaniasis in human beings. In four out of eight cultures from human cases of tegumentary leishmaniasis performed, the ethiological agent of "espundia" was isolated. As a result of entomological studies, 868 specimens of "titiras" were captured, corresponding to nine species of the Genus Lutzomyia; the findings point out that 79.8% of the insects were L. auraensis and 12% L. migoni. The occurrence of metastasic injuries in the oral, nasal and pharingeal mucosae, as well as the presence of positive Montenegro reaction, without evidence of any past or present Leishmaniasis infection in Alto Tambopata shows that "espundia" does not differ from the disease that occurs in other South American countries where "espundia" is endemic.
- Published
- 1999
225. Seroconversion rates among health care workers exposed to hepatitis C virus-contaminated body fluids: The University of Pittsburgh 13-year experience.
- Author
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Egro FM, Nwaiwu CA, Smith S, Harper JD, and Spiess AM
- Subjects
- Body Fluids virology, Cohort Studies, Coinfection, HIV isolation & purification, HIV Infections diagnosis, HIV Infections immunology, HIV Infections transmission, HIV Infections virology, Hepatitis B diagnosis, Hepatitis B immunology, Hepatitis B transmission, Hepatitis B virology, Hepatitis B virus isolation & purification, Hepatitis C immunology, Hepatitis C transmission, Hepatitis C virology, Humans, Needlestick Injuries immunology, Needlestick Injuries virology, Occupational Exposure statistics & numerical data, Pennsylvania, Health Personnel, Hepacivirus isolation & purification, Hepatitis C diagnosis, Infectious Disease Transmission, Patient-to-Professional statistics & numerical data, Needlestick Injuries diagnosis, Seroconversion
- Abstract
Background: Hepatitis C virus (HCV) transmission to health care personnel (HCP) after exposure to a HCV-positive source has been reported to occur at an average rate of 1.8% (range, 0%-10%). We aimed to determine the seroconversion rate after exposure to HCV-contaminated body fluid in a major U.S. academic medical center., Methods: A longitudinal analysis of a prospectively maintained database of reported occupational injuries occurring between 2002 and 2015 at the University of Pittsburgh Medical Center was performed. Data collected include type of injury and fluid, injured body part, contamination of sharps, resident physicians' involvement, and patients' hepatitis B virus (HBV), HCV, and HIV status., Results: A total of 1,361 cases were included in the study. Most exposures were caused by percutaneous injuries (65.0%), followed by mucocutaneous injuries (33.7%). Most (63.3%) were injuries to the hand, followed by the face and neck (27.6%). Blood exposure accounted for 72.7%, and blood-containing saliva accounted for 3.4%. A total of 6.9% and 3.7% of source patients were coinfected with HIV and HBV, respectively. The HCV seroconversion rate was 0.1% (n = 2) because of blood exposure secondary to percutaneous injuries., Conclusions: This study provides the largest and most recent cohort from a major U.S. academic medical center. The seroconversion rates among HCP exposed to HCV-contaminated body fluids was found to be lower than most of the data found in the literature., (Copyright © 2017 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.)
- Published
- 2017
- Full Text
- View/download PDF
226. Seroconversion rate among health care workers exposed to HIV-contaminated body fluids: The University of Pittsburgh 13-year experience.
- Author
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Nwaiwu CA, Egro FM, Smith S, Harper JD, and Spiess AM
- Subjects
- Anti-HIV Agents therapeutic use, Health Personnel, Hospitals, University, Humans, Infectious Disease Transmission, Patient-to-Professional, Occupational Exposure, Pennsylvania, Retrospective Studies, Anti-HIV Agents administration & dosage, Body Fluids virology, HIV Infections transmission, HIV Seropositivity epidemiology, Post-Exposure Prophylaxis methods
- Abstract
Background: The studies enumerating the risk of HIV transmission to health care workers (HCWs) as 0.3% after percutaneous exposure to HIV-positive blood, and 0.09% after a mucous membrane exposure, are weakened by dated literature. Our study aims to demonstrate the seroconversion rate after exposure to HIV-contaminated body fluids in a major academic center in the United States., Methods: A prospectively maintained database of reported occupational injuries occurring between 2002 and 2015 at an academic medical center was analyzed. Data collected included the type of injury, injured body part, type of fluid, contamination of sharps, involvement of resident physicians, use of postexposure prophylaxis, and patients' HIV, hepatitis B virus, and hepatitis C virus status., Results: A total of 266 cases were included in the study. Most exposures were caused by percutaneous injuries (52.6%), followed by 43.2% mucocutaneous injuries. Of the injuries, 52.6% were to the hand and 33.5% to the face and neck. Blood exposure accounted for 64.3% of all cases. Of the patients, 21.1% received postexposure prophylaxis. None of the HCWs exposed to HIV-contaminated body fluids seroconverted (seroconversion rate, 0%)., Conclusions: HIV does not seem to be as easily transmitted by needlestick, laceration, or splash injuries as previously surmised. Further large-scale and multicenter studies are needed for a more accurate estimation of the risk of transmission of HIV in U.S. health care workers., (Copyright © 2017 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.)
- Published
- 2017
- Full Text
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227. Mucocutaneous Manifestations in Patients with Rheumatoid Arthritis: A Cross-sectional Study from Eastern India.
- Author
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Ghosh SK, Bandyopadhyay D, Biswas SK, and Darung I
- Abstract
Background: Cutaneous manifestations are fairly common in rheumatoid arthritis (RA) and they can help in early diagnosis, prompt treatment, and hence reduced morbidity from the disease., Aims: The objective of the present study was to find out the different patterns of dermatoses in a group of patients with RA from Eastern India., Methodology: Consecutive patients fulfilling the American Rheumatism Association 1987 revised criteria for the classification of RA and who had different dermatoses were included in this cross-sectional study done over a period of 8 years in a tertiary care hospital in Eastern India. Thorough clinical examination and appropriate laboratory investigations were performed as needed. Data were recorded in a predesigned schedule, and appropriate statistical analysis was done., Results: We studied 111 evaluable patients with an age range of 19-71 years and a female to male ratio of 7:1. The mean disease duration of RA was 6.5 years. Cutaneous infections as a group was the most common mucocutaneous manifestation (34.2%) followed by xerosis including ichthyotic skin changes (27%), pigmented purpuric dermatoses (14.4%), leg ulcer (9.9%), periungual telangiectasia (9.9%), rheumatoid nodules (RNs) (8.1%), purpura and ecchymoses (7.2%), small vessel vasculitis in (7.2%), corn and callosities (6.3%), palmar erythema (4.5%), and neutrophilic dermatosis (4.5%). Raynaud's phenomenon was found in 3.6% patients and panniculitis in (3.6%) patients. Rheumatoid factor (RF) and anti-cyclic citrullinated peptides antibody were positive in 74.8% and 88.3% patients, respectively. No statistically significant difference of incidence of leg ulcer, small vessel vasculitis, RN, or Raynaud's phenomenon could be noted between RF positive and negative groups., Limitations: Being an institution-based study, the study findings may not reflect the true situation in the community which remained a limitation of this study., Conclusion: While some of the features of this study were analogous to Western data, other features showed discordance which may be due to ethnic variations among the patients with RA., Competing Interests: There are no conflicts of interest. What is new? The present study highlighted the patterns of mucocutaneous manifestations in a group of patients from Eastern IndiaWhereas some of the features of this study are comparable to Western data, other features showed discordance to the existing data which may be due ethnic variations of the patients with rheumatoid arthritis.
- Published
- 2017
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228. Dasatinib-induced Seborrheic Dermatitis-like Eruption.
- Author
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Riahi RR and Cohen PR
- Abstract
Dasatinib is an oral tyrosine kinase inhibitor approved for imatinib-resistant chronic myelogenous leukemia. It has been investigated in treating other neoplasms, including non-small-cell lung cancer and a subset of melanomas. Seborrheic dermatitis is characterized by erythematous patches or plaques with scaling typically affecting the external ear, glabella, hair-bearing areas of the face, nasolabial fold, and scalp. Antitumor agents are often associated with mucocutaneous side effects, including seborrheic dermatitis. We describe the case of a 79-year-old woman with a history of sinonasal melanoma who developed a seborrheic dermatitis-like eruption while taking dasatinib. We also review the molecular abnormalities associated with melanoma, summarize the mucocutaneous side effects of dasatinib, and list the other antineoplastic agents associated with a seborrheic dermatitis-like eruption., Competing Interests: FUNDING:No funding was provided. DISCLOSURES:The authors have no conflicts of interest relevant to the contents of this article.
- Published
- 2017
229. Field Validation of SYBR Green- and TaqMan-Based Real-Time PCR Using Biopsy and Swab Samples To Diagnose American Tegumentary Leishmaniasis in an Area Where Leishmania (Viannia) braziliensis Is Endemic.
- Author
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Gomes CM, Cesetti MV, de Paula NA, Vernal S, Gupta G, Sampaio RN, and Roselino AM
- Subjects
- Adult, Aged, Benzothiazoles, Biopsy, Diamines, Female, Humans, Leishmaniasis, Mucocutaneous epidemiology, Male, Middle Aged, Organic Chemicals, Prospective Studies, Quinolines, Sensitivity and Specificity, Staining and Labeling, Endemic Diseases, Leishmania braziliensis isolation & purification, Leishmaniasis, Mucocutaneous diagnosis, Molecular Diagnostic Techniques methods, Real-Time Polymerase Chain Reaction methods
- Abstract
The precise diagnosis of American tegumentary leishmaniasis (ATL) is an essential task due to the disease's associated morbidity. A noninvasive, extremely sensitive, and highly specific exam is critical, particularly for mucosal leishmaniasis (ML), in which a low parasite quantity is expected. We aimed to compare the diagnostic accuracy of swab and biopsy sample analysis using SYBR Green- and TaqMan-based real-time PCR (qPCR) assays with that of a composite reference standard consisting of the Montenegro skin test, serology, histopathology, smears, culture, and conventional PCR. In total, 55 patients with ATL (ML, 18 patients; cutaneous leishmaniasis [CL], 37 patients) and 36 patients without ATL were studied. qPCR analysis of swabs was more accurate when using SYBR Green (87.88%; 95% confidence interval [CI], 77.86 to 93.73 patients) than when using TaqMan (78.79%; 95% CI, 67.49 to 86.92%) (P = 0.031). SYBR Green (84.72%; 95% CI, 74.68 to 91.25%) was also more accurate than TaqMan (73.61%; 95% CI, 62.42 to 82.41%) for biopsy samples (P = 0.008). All qPCR methods were 100% specific. Swabs and biopsy specimens had similar sensitivity when using the same chemistry (P = 0.125 for SYBR Green and P = 0.625 for TaqMan). Moreover, qPCR achieved better performance than most existing techniques used for the diagnosis of ATL and also detected the Leishmania parasite in a greater proportion of patients than the associated histopathology, smear, culture, and conventional PCR techniques did. Swabs therefore represent a useful diagnostic tool because they not only are noninvasive but also can achieve an accuracy similar to that of biopsy samples. The high accuracy of SYBR Green-based qPCR may also reduce the requirement for associated parasitological tests for ATL diagnosis., (Copyright © 2017 American Society for Microbiology.)
- Published
- 2017
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230. Prevalence of oral, skin, and oral and skin lesions of lichen planus in patients visiting a dental school in Southern India
- Author
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Akhilesh Prathap, Nebu George Thomas, Vimal Jacob, and PM Omal
- Subjects
medicine.medical_specialty ,mucocutaneous ,Mucocutaneous zone ,Population ,Dentistry ,Dermatology ,precancerous ,Statistical significance ,lcsh:Dermatology ,medicine ,education ,Prospective cohort study ,education.field_of_study ,integumentary system ,medicine.diagnostic_test ,business.industry ,lcsh:RL1-803 ,Middle age ,stomatognathic diseases ,Skin biopsy ,Original Article ,Lichen planus ,business ,Skin lesion ,Oral medicine - Abstract
Background: Lichen planus (LP) is a mucocutaneous disease that is relatively common among adult population. LP can present as skin and oral lesions. This study highlights the prevalence of oral, skin, and oral and skin lesions of LP. Aims: The aim of this study was to evaluate the prevalence of oral, skin, and oral and skin lesions of LP from a population of patients attending the Department of Oral Medicine and Radiodiagnosis, Pushpagiri College of Dental Sciences, Tiruvalla, Kerala, India. Materials and Methods: A cross-sectional study was designed to evaluate the prevalence of oral, skin, and oral and skin lesions of LP. This is a ongoing prospective study with results of 2 years being reported. LP was diagnosed on the basis of clinical presentation and histopathological analysis of mucosal and skin biopsy done for all patients suspected of having LP. Statistical analysis was carried out using SPSS (Statistical package for social sciences) software version 14. To test the statistical significance, chi-square test was used. Results: Out of 18,306 patients screened, 8,040 were males and 10,266 females. LP was seen in 118 cases (0.64%). Increased prevalence of LP was observed in middle age adults (40–60 years age group) with lowest age of 12 years and highest age of 65 years. No statistically significant differences were observed between the genders in skin LP group (P=0.12) and in oral and skin LP groups (P=0.06); however, a strong female predilection was seen in oral LP group (P=0.000036). The prevalence of cutaneous LP in oral LP patients was 0.06%. Conclusion: This study showed an increased prevalence of oral LP than skin LP, and oral and skin LP with a female predominance.
- Published
- 2012
231. Espondilodiscitis y artritis de tobillo por Candida albicans en escolar
- Author
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González I, Luís Hernán, Wu H, Elba, Miranda A, Marta, and Rojas A, Patricio
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osteoartritis ,spondilodyscitis ,mucocutaneous ,osteoarticular ,espondilodiscitis ,candidiasis mucocutanea ,candidiasis - Published
- 1992
232. Mucocutaneous nasal histoplasmosis in an immunocompetent young adult
- Author
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V. Ramesh, Neelam Sood, Rashmi Batra, Harish C. Gugnani, and Arvind A. Padhye
- Subjects
Adult ,Male ,Pathology ,medicine.medical_specialty ,Mucocutaneous ,Itraconazole ,Mucocutaneous zone ,Dermatology ,Histoplasmosis ,Nose Diseases ,Biopsy ,lcsh:Dermatology ,otorhinolaryngologic diseases ,Dermatomycoses ,Humans ,Medicine ,Young adult ,Histiocyte ,Mycosis ,Nose ,medicine.diagnostic_test ,business.industry ,lcsh:RL1-803 ,Nasal histoplasmosis ,medicine.disease ,Nasal Mucosa ,Infectious Diseases ,medicine.anatomical_structure ,Histoplasma capsulatum var. capsulatum ,business ,Immunocompetence ,medicine.drug - Abstract
A case of mucocutaneous nasal histoplasmosis in an immunocompetent host is described below. A 30-year-old male had a broadened nose with swelling and repeated blockage of nasal passages for the past six months. Diagnosis was made on the basis of histological demonstration of characteristic yeast cells of Histoplasma capsulatum var. capsulatum occurring within histiocytes and extracellularly in stained smears of fine needle aspirates and biopsy from the lesions in ala of the nose and perioral region. The patient showed appreciable regression of lesions after three weeks of itraconazole therapy but was not available for re-assessment.
- Published
- 2007
233. Nosocomial Dengue by Mucocutaneous Transmission
- Author
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Mary E. Wilson and Lin H. Chen
- Subjects
Adult ,Microbiology (medical) ,medicine.medical_specialty ,Letter ,Infectious Disease Transmission, Patient-to-Professional ,travel illness ,mucocutaneous ,Epidemiology ,Virus transmission ,Mucocutaneous zone ,lcsh:Medicine ,Nursing Staff, Hospital ,Dengue virus ,Antibodies, Viral ,medicine.disease_cause ,Dengue fever ,lcsh:Infectious and parasitic diseases ,Humans ,Medicine ,lcsh:RC109-216 ,Letters to the Editor ,Needlestick Injuries ,blood-borne pathogen ,Reverse Transcriptase Polymerase Chain Reaction ,business.industry ,Transmission (medicine) ,lcsh:R ,Healthcare worker ,nosocomial ,Dengue Virus ,Phlebotomy ,virus transmission ,medicine.disease ,Virology ,dengue ,Infectious Diseases ,Emergency medicine ,RNA, Viral ,Female ,business ,human activities - Abstract
We have recently published a case of nosocomial dengue infection that was transmitted by mucocutaneous exposure to blood from a febrile traveler who had recently returned from Peru (6). During phlebotomy, a healthcare worker was splashed in the face with the traveler’s blood. Both the traveler and the healthcare worker were subsequently found to have dengue fever with dengue virus type 3. This route of infection is biologically plausible because infection through mucosal surfaces (intranasal and oral routes) has been shown pos
- Published
- 2005
234. Cryptococcal cellulitis in a heart transplant recipient.
- Author
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Ashchyan HJ, Blumberg E, Cedeno-Laurent F, Olson T, Xu X, Taylor LA, Micheletti RG, and Rosenbach M
- Published
- 2016
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235. Cutaneous leishmaniasis caused by Leishmania (Viannia) panamensis in 2 travelers.
- Author
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Achtman JC, Ellis DL, Saylors B, and Boh EE
- Published
- 2016
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236. Subcutaneous rhinosporidiosis masquerading as soft tissue tumor: diagnosed by fine-needle aspiration cytology.
- Author
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Kishan Prasad HL, Rao C, Girisha BS, Shetty V, Permi HS, Jayakumar M, and Kiran HS
- Abstract
Rhinosporidiosis is a chronic granulomatous lesion caused by Rhinosporidium seeberi. It frequently involves nasopharynx and ocular region. Presenting as cutaneous and subcutaneous mass is extremely rare. This report describes the FNA cytology of rhinosporidiosis occurring as a soft tissue mass in the right mid thigh region. We present a rare case of a 71-year-old male, who presented with multiple subcutaneous soft tissue mass lesions in the posteromedial aspect of mid right thigh region since 2 weeks. Local examination revealed multiple firm to hard mass with skin over the swelling was unremarkable. CT of the right thigh showed a heterogeneous lesion with infiltrative margins in the thigh. Clinically soft tissue sarcoma was considered. Diagnostic FNAC was performed showing numerous mature and immature sporangias with giant cell reaction. Hence, an excision biopsy confirmed the rhinosporidiosis. To conclude, the FNAC diagnosis of rhinosporidiosis is specific. Preoperative diagnosis is possible even in cases with unusual clinical presentations.
- Published
- 2015
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237. Mucocutaneous leishmaniasis: accuracy and molecular validation of noninvasive procedures in a L. (V.) braziliensis-endemic area.
- Author
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Gomes CM, de Paula NA, Cesetti MV, Roselino AM, and Sampaio RN
- Subjects
- Adult, Aged, Aged, 80 and over, Case-Control Studies, DNA, Kinetoplast, Female, Humans, Leishmania classification, Leishmania isolation & purification, Male, Middle Aged, Polymerase Chain Reaction methods, Reproducibility of Results, Sensitivity and Specificity, Leishmania genetics, Leishmaniasis, Mucocutaneous diagnosis, Leishmaniasis, Mucocutaneous parasitology
- Abstract
The aim of this study was to evaluate the effectiveness of polymerase chain reaction (PCR) using Kinetoplastid DNA (kDNA) from nasal swabs (NSs), saliva, and oral filter paper imprints (OFPI) in diagnosing mucocutaneous leishmaniasis (ML) and cutaneous leishmaniasis (CL). Seventeen patients with ML, 19 patients with CL, and 33 controls were evaluated. In patients with ML, PCR from NS showed an 86% diagnostic accuracy (95% confidence interval [CI] = 73.81-93.05), followed by saliva 74% (95% CI = 60.45-84.13) and OFPI 68% (95% CI = 54.19-79.24). The highest sensitivity was reached by using the NS 58.82% (95% CI = 36.01-78.39), followed by saliva 23.53% (95% CI = 9.56-47.26) and OFPI 5.88% (95% CI = 1.05-26.98). The specificities of the tests were complete. The NS and OFPI were positive in 2 cases of CL. Mucous membrane samples exhibited a higher specificity compared to the Montenegro skin test and indirect immunofluorescence. NS sensitivity was higher than that of parasitological examinations., (Copyright © 2014 Elsevier Inc. All rights reserved.)
- Published
- 2014
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238. Prevalence of oral, skin, and oral and skin lesions of lichen planus in patients visiting a dental school in southern India.
- Author
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Omal P, Jacob V, Prathap A, and Thomas NG
- Abstract
Background: Lichen planus (LP) is a mucocutaneous disease that is relatively common among adult population. LP can present as skin and oral lesions. This study highlights the prevalence of oral, skin, and oral and skin lesions of LP., Aims: The aim of this study was to evaluate the prevalence of oral, skin, and oral and skin lesions of LP from a population of patients attending the Department of Oral Medicine and Radiodiagnosis, Pushpagiri College of Dental Sciences, Tiruvalla, Kerala, India., Materials and Methods: A cross-sectional study was designed to evaluate the prevalence of oral, skin, and oral and skin lesions of LP. This is a ongoing prospective study with results of 2 years being reported. LP was diagnosed on the basis of clinical presentation and histopathological analysis of mucosal and skin biopsy done for all patients suspected of having LP. Statistical analysis was carried out using SPSS (Statistical package for social sciences) software version 14. To test the statistical significance, chi-square test was used., Results: Out of 18,306 patients screened, 8,040 were males and 10,266 females. LP was seen in 118 cases (0.64%). Increased prevalence of LP was observed in middle age adults (40-60 years age group) with lowest age of 12 years and highest age of 65 years. No statistically significant differences were observed between the genders in skin LP group (P=0.12) and in oral and skin LP groups (P=0.06); however, a strong female predilection was seen in oral LP group (P=0.000036). The prevalence of cutaneous LP in oral LP patients was 0.06%., Conclusion: This study showed an increased prevalence of oral LP than skin LP, and oral and skin LP with a female predominance.
- Published
- 2012
- Full Text
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