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Advanced oxidation processes (AOPs) based on the metal–organic frameworks (MOFs) and peroxymonosulfate (PMS) have been demonstrated as promising methods for the degradation of contaminants. In this study, the degradation of bisphenol AF (BPAF) by activated PMS via amino-modified metal–organic frameworks (AMOF) was investigated thoroughly. BPAF could be efficiently removed (94.1%) in the optimal condition. The decontamination of BPAF could be accelerated significantly with the increasing temperature, and a highly stable degradation performance was observed at a wide pH range. Quenching experiments and electron paramagnetic resonance (EPR) tests revealed that sulfate radical (SO4–•), hydroxyl radical (HO•), singlet oxygen (1O2), and superoxide radical (O2–•) were produced synergistically in the AMOF/PMS system. Chloride ion (Cl–) exhibited a dual influence on BPAF removal, while other anions and NOM could hinder the degradation rate mildly. A total of fifty-two intermediates were identified using UHPLC-MS/MS method and four main degradation pathways were proposed based on the density functional theory (DFT) calculation, including the frontier molecular orbital theory (FMO), natural population analysis (NPA), and Fukui function. Finally, the Quantitative Structure Activity Relationship (QSAR) method for Toxicity Estimation Software Tool (TEST) was applied to estimate the accurate toxicity of BPAF and degradation byproducts. This study exhibited the promising potential for the decontamination of BPAF in the water via the AMOF based AOPs. © 2021

This study aimed to seek an effective approach for graphitic carbon nitride (g-C3N4) modification to enhance the non-photocatalytic performance on peroxydisulfate (PDS) activation. Herein, a simple one-step thermal polymerization technique was developed to modulate electronic structures of g-C3N4 by compositing with waste coffee grounds. The formed sandwich-like carbocatalysts (coffee grounds-derived graphitic carbon nitride, Cs/g-C3N4) exhibited an excellent performance on PDS activation toward bisphenol A oxidation via a nonradical pathway. The abundant unpaired electrons around the dangling bonds on the Cs/g-C3N4 surface, which were formed by the mutual substitution of N and C atoms between Cs and g-C3N4 during the annealing process, could be deprived by PDS, forming the reactive electron-deficient carbocatalysts ([Cs/g-C3N4]*) along with a spot of singlet oxygen (1O2) generation to oxidize the organic pollutants. The graphitic N and structural defects might serve as the active sites to offer the unpaired electrons. Compared to singlet oxygen, [Cs/g-C3N4]* revealed a higher mineralization efficiency to reduce the residual ecotoxicity, exhibiting a certain potential in practical applications. © 2021 Elsevier Ltd

Yongli Zhang,1,2 Yanyan Niu,1,2 Hong Huo,1,2 Jian Wang,1,2 Xiaofeng Jin,1,2 Hua Yang1,2 1Peking Union Medical College, Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, Department of Otolaryngology, Beijing, People’s Republic of China; 2Translational Medicine Center, Peking Union Medical College Hospital, Beijing, People’s Republic of ChinaCorrespondence: Jian Wang; Hua Yang, Department of Otolaryngology, Peking Union Medical College Hospital, Beijing, People’s Republic of China, 100730, Tel +13673164261 ; +13701127757, Fax +86-10-69156311, Email wangjianent@163.com; dr_yanghua2021@163.comPurpose: Biofilms on voice prostheses are important factors shortening their service life. Sodium selenite has been used to prevent and treat various diseases. Whether sodium selenite can inhibit and remove mature biofilms on voice prostheses is still unknown.Methods: To verify the effects of sodium selenite on mature mixed-bacteria biofilms (Staphylococcus aureus, Candida albicans, and Streptococcus faecalis) on voice prostheses, we used quantitative and qualitative methods, eg, real-time fluorescence quantitative PCR, crystal violet staining, 2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide) (XTT) reduction assays, and scanning electron microscopy, to measure the effects of sodium selenite on the number of bacterial colonies, biofilm formation ability, metabolic activity, and ultrastructure in a model of mature mixed-bacteria biofilms on voice prostheses and validated the effects in vitro on mature biofilms on voice prostheses from patients.Results: When exploring the possible mechanism of biofilm inhibition and removal by sodium selenite, we found that it significantly inhibited and removed biofilms on voice prostheses and effectively destroyed the spatial structure of the biofilms. The inhibition and removal effects became more significant with increasing sodium selenite concentrations.Conclusion: We demonstrated that sodiu

Huixia Feng,1– 4 Guilin Chen,1– 4 Yongli Zhang,1– 4 Mingquan Guo1– 4 1Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan, 430074, People’s Republic of China; 2University of Chinese Academy of Sciences, Beijing, 100049, People’s Republic of China; 3Sino-Africa Joint Research Center, Chinese Academy of Sciences, Wuhan, 430074, People’s Republic of China; 4Innovation Academy for Drug Discovery and Development, Chinese Academy of Sciences, Shanghai, 201203, People’s Republic of ChinaCorrespondence: Mingquan Guo, Tel +86-02787700850, Email guomq@wbgcas.cnBackground: Dysosma versipellis (D. versipellis) has been traditionally used as a folk medicine for ages. However, the specific phytochemicals responsible for their correlated anti-inflammatory, anti-proliferative and antiviral activities remain unknown.Purpose: This study aimed to explore the specific active components in D. versipellis responsible for its potential anti-inflammatory, anti-proliferative, and antiviral effects, and further elucidate the corresponding mechanisms of action.Methods: Bioaffinity ultrafiltration coupled to liquid chromatography–mass spectrometry (UF-LC/MS) was firstly hired to fast screen for the anti-inflammatory, anti-proliferative and antiviral compounds from rhizomes of D. versipellis, and then further validation was conducted using in vitro inhibition assays and molecular docking.Results: A total of 12, 12, 9 and 12 phytochemicals with considerable affinities to Topo I, Topo II, COX-2 and ACE2 were fished out, respectively. The anti-proliferative assay in vitro indicated that podophyllotoxin and quercetin exhibited comparably strong inhibitory rates on A549 and HT-29 cells compared with 5-FU and etoposide. Meanwhile, kaempferol displayed prominent dose-dependent inhibition against COX-2 with IC50 value at 0.36 &plus