5,434 results on '"Yalcinkaya A"'
Search Results
352. HDL inhibits endoplasmic reticulum stress-induced apoptosis of pancreatic β-cells in vitro by activation of Smoothened[S]
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Mustafa Yalcinkaya, Anja Kerksiek, Katrin Gebert, Wijtske Annema, Rahel Sibler, Silvija Radosavljevic, Dieter Lütjohann, Lucia Rohrer, and Arnold von Eckardstein
- Subjects
adenosine 5′-triphosphate binding cassette transporter ,cytochrome P450 enzyme ,high density lipoprotein ,cholesterol efflux ,cholesterol metabolism ,oxysterols ,Biochemistry ,QD415-436 - Abstract
Loss of pancreatic β-cell mass and function as a result of sustained ER stress is a core step in the pathogenesis of diabetes mellitus type 2. The complex control of β-cells and insulin production involves hedgehog (Hh) signaling pathways as well as cholesterol-mediated effects. In fact, data from studies in humans and animal models suggest that HDL protects against the development of diabetes through inhibition of ER stress and β-cell apoptosis. We investigated the mechanism by which HDL inhibits ER stress and apoptosis induced by thapsigargin, a sarco/ER Ca2+-ATPase inhibitor, in β-cells of a rat insulinoma cell line, INS1e. We further explored effects on the Hh signaling receptor Smoothened (SMO) with pharmacologic agonists and inhibitors. Interference with sterol synthesis or efflux enhanced β-cell apoptosis and abrogated the anti-apoptotic activity of HDL. During ER stress, HDL facilitated the efflux of specific oxysterols, including 24-hydroxycholesterol (OHC). Supplementation of reconstituted HDL with 24-OHC enhanced and, in cells lacking ABCG1 or the 24-OHC synthesizing enzyme CYP46A1, restored the protective activity of HDL. Inhibition of SMO countered the beneficial effects of HDL and also LDL, and SMO agonists decreased β-cell apoptosis in the absence of ABCG1 or CYP46A1. The translocation of the SMO-activated transcription factor glioma-associated oncogene GLI-1 was inhibited by ER stress but restored by both HDL and 24-OHC. In conclusion, the protective effect of HDL to counter ER stress and β-cell death involves the transport, generation, and mobilization of oxysterols for activation of the Hh signaling receptor SMO
- Published
- 2020
- Full Text
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353. Posttranscriptional Regulation of the Human LDL Receptor by the U2-Spliceosome
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Zanoni, Paolo, Panteloglou, Grigorios, Othman, Alaa, Haas, Joel T., Meier, Roger, Rimbert, Antoine, Futema, Marta, Khalil, Yara Abou, Norrelykke, Simon F., Rzepiela, Andrzej J., Stoma, Szymon, Stebler, Michael, van Dijk, Freerk, Wijers, Melinde, Wolters, Justina C., Dalila, Nawar, Huijkman, Nicolette C. A., Smit, Marieke, Gallo, Antonio, Carreau, Valérie, Philippi, Anne, Rabès, Jean- Pierre, Boileau, Catherine, Visentin, Michele, Vonghia, Luisa, Weyler, Jonas, Francque, Sven, Verrijken, An, Verhaegen, Ann, Van Gaal, Luc, van der Graaf, Adriaan, van Rosmalen, Belle V., Robert, Jerome, Velagapudi, Srividya, Yalcinkaya, Mustafa, Keel, Michaela, Radosavljevic, Silvija, Geier, Andreas, Tybjaerg-Hansen, Anne, Varret, Mathilde, Rohrer, Lucia, Humphries, Steve E., Staels, Bart, van de Sluis, Bart, Kuivenhoven, Jan Albert, and von Eckardstein, Arnold
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- 2021
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354. Is Case-Based Instruction Effective in Enhancing High School Students' Motivation toward Chemistry?
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Yalcinkaya, Eylem, Boz, Yezdan, and Erdur-Baker, Ozgur
- Abstract
The aim of this study was to investigate the effectiveness of case-based learning (CBL) over traditionally designed chemistry instruction (TDCI) on 10th grade students' perceived motivation about chemistry as a school subject. Two classes were randomly selected from a high school. One class was assigned to be an experimental group and the other was assigned as a control group. A total of 45 high school students from 10th grade were the participants of the study (25 experimental and 20 control group students). Students in the experimental group were taught by case-based instruction while the control group students received traditional instruction. Motivated Strategies for Learning Questionnaire (MSLQ) was administered to both groups of students as pre- and post-tests to measure their perceived motivation. The results of one-way MANOVA based on gain scores revealed that CBL was an effective method for promoting students' motivation towards chemistry. (Contains 4 tables.)
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- 2012
355. A Qualitative Study on Change Management in Primary Schools Award Winning and Non-Award Winning Schools Case in Study of TQM
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Altunay, Esen, Arli, Didem, and Yalcinkaya, Munevver
- Abstract
The aim of this study was to determine the need of change in primary schools and to reveal out the principals' experiences during the change process by taking the total quality management practices into consideration and finally give suggestions according to the results of the study. In this study by employing qualitative research method, semi structured interview technique was preferred. The sample of the study was composed of the school principals whose schools both received and could not receive Total Quality Management Award during the 2009-2010 academic year in Bornova, Buca, Gaziemir, Karsiyaka provinces of Izmir. The findings of the study revealed out that teams were formed up, documents were prepared, but the teams in the schools that took awards worked more actively than the teams in schools that did not take any awards. The principals in the schools with awards mentioned that they were aware of the works of the teams and provided the required equipment for these teams. (Contains 1 table.)
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- 2012
356. Characterization of Ti–6Al–(4V–7Nb–4Mo) Biomedical Alloys Produced by Powder Metallurgy Method
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Aygul, Ebuzer, Yalcinkaya, Senai, and Sahin, Yusuf
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- 2020
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357. Solvent effects on UV–Vis and FT-IR spectra of indapamide combined with DFT calculations
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Bolukbasi Yalcinkaya, Olcay, Yilmaz, Ayberk, and Ilhan Ceylan, Berat
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- 2020
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358. Local excision versus thrombectomy in thrombosed external hemorrhoids : a multicenter, prospective, observational study
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Yalcinkaya, Ali, Yalcinkaya, Ahmet, Atici, Semra Demirli, Sahin, Can, Leventoglu, Sezai, Collaboration, T E H Study, Yalcinkaya, Ali, Yalcinkaya, Ahmet, Atici, Semra Demirli, Sahin, Can, Leventoglu, Sezai, and Collaboration, T E H Study
- Abstract
Background: Available guidelines describing the procedural treatment of thrombosed external hemorrhoids (TEH) rely solely on expert opinion. We aimed to compare local excision (LE) and thrombectomy (incision) in terms of treatment success, factors affecting success, and outcomes. Methods: This was a multicenter, prospective, observational study conducted in eight centers from September 2020 to September 2021. A total of 96 patients (58 LE, 38 thrombectomy) were included. Risk factors, demographics and clinical characteristics were recorded. Follow-up studies were scheduled for the 1(st) week, 1(st), 3(rd) and 6(th) months. Surgical success was assessed at 1 month. Hemorrhoidal Disease Symptom Score (HDSS) and Short Health Scale (SHS) were applied at baseline and the 6(th) month. Wexner fecal incontinence score was applied at all follow-up studies. Results: Overall mean age was 41.5 & PLUSMN; 12.7 years. At baseline, groups were similar with regard to demographics and disease severity (HDSS) (p > 0.05 for all). Success was relatively higher in the thrombectomy group (86.8%) compared to the LE group (67.2%) (p = 0.054). Constipation and travel history were significantly associated with lower likelihood of LE success. Symptoms during follow-up were similarly distributed in the groups. Both methods yielded significant improvements in HDSS, SHS and Wexner scores; however, SHS scores (6 months) and Wexner scores (all time points) were significantly better in the thrombectomy group. Conclusion: The in-office thrombectomy procedure may have better short-term outcomes compared to LE in terms of relative success, recurrence and quality of life-despite the fact that success rates were statistically similar with the two interventions. LE may yield particularly worse results in patients with constipation and travel history; thus, thrombectomy appears to be especially advantageous in these patient subsets.
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- 2023
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359. Safety and efficacy of intraperitoneal drain placement after emergency colorectal surgery: An international, prospective cohort study
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Sgro, A, Blanco-Colino, R, Ahmed, W, Brindl, N, Gujjuri, R, Lapolla, P, Mills, E, Perez-Ajates, S, Soares, A, Varghese, C, Xu, W, Mclean, K, Chapman, S, Espin-Basany, E, Glasbey, J, Mihaljevic, A, Nepogodiev, D, Pata, F, Pellino, G, Pockney, P, Dudi-Venkata, N, Egoroff, N, Ludbrook, I, Raubenheimer, K, Richards, T, Delibegovic, S, Salibasic, M, Amjad, T, Dorr-Harim, C, Gedeon, N, Gsenger, J, Tachezy, M, Bini, S, Gallo, G, Gori, A, Picciariello, A, Podda, M, Riboni, C, Machatschek, M, Nguyen, A, Jakubauskas, M, Kryzauskas, M, Poskus, T, Kuiper, S, Wang, J, Wells, C, Bissett, I, Augestad, K, Steinholt, I, Vieira, B, Juloski, J, Anabitarte Bautista, O, Kasmy El Kasmy, Y, Martin-Borregon, P, Ossola Revilla, M, Van Straten, S, Aktas, M, Baki, B, Akhbari, M, Baker, D, Bhatia, S, Brown, S, Cambridge, W, Kamarajah, S, Khaw, R, Kouli, O, Murray, V, Trout, I, Yasin, I, Wong, J, Reyhani, H, Wong, K, Pancharatnam, R, Chia, W, Walmsley, A, Hassane, A, Saeed, D, Wang, B, Walters, B, Nowinka, Z, Alsaif, A, Mirza, M, Foster, K, Luu, J, Kakodkar, P, Hughes, J, Yogarajah, T, Antypas, A, Rahman, A, Bradbury, M, Mclarnon, M, Nagi, S, Riad, A, Erotocritou, M, Kyriacou, H, Kaminskaite, V, Alfadhel, S, Fatimah Hussain, Q, Handa, A, Massy-Westropp, C, Custovic, S, Dimov, R, Mughal, H, Slavchev, M, Ivanov, T, Gouvas, N, Hegazi, A, Kocian, P, Kjaer, M, Mark-Christensen, A, Papakonstantinou, D, Machairas, N, Triantafyllou, T, Garoufalia, Z, Korkolis, D, Castaldi, A, Giaccari, S, Spolverato, G, Pagano, G, Milone, M, Turri, G, Colombo, F, Cucinotta, E, Poillucci, G, Perra, T, Tutino, R, Belia, F, Coletta, D, Belli, A, Rega, D, Cianci, P, Pirozzolo, G, Di Lena, M, Perrone, F, Giani, A, Lovisetto, F, Grassia, M, Pipitone Federico, N, Ferrara, F, Biancafarina, A, Tamini, N, Sinibaldi, G, Tuminello, F, Galleano, R, Sasia, D, Bragaglia, L, de Manzoni Garberini, A, Pesce, A, Cassaro, F, Venturelli, P, Canu, G, Esposito, G, Campanelli, M, Cardia, R, Ricciardiello, M, Sagnotta, A, Canonico, G, De Marco, G, Cappiello, A, Pinotti, E, Carlei, F, Lisi, G, Bagaglini, G, Farrugia, M, Meima - van Praag, E, Monteiro, C, Pereira, M, Botelho, P, Quigley, A, O'Neill, A, Gaule, L, Crone, L, Arnold, A, Grama, F, Beuca, A, Tulina, I, Litvin, A, Panyko, A, Ossola, M, Trujillo Diaz, J, Marin Santos, J, Alonso Batanero, E, Gortazar de las Casas, S, Soldevila Verdeguer, C, Colas-Ruiz, E, Talal El-Abur, I, Garcia Dominguez, M, Delorme, M, Sauvain, M, Ozmen, B, Ozkan, B, Calikoglu, F, Kural, S, Zafer, F, Kaya, Y, Yalcinkaya, A, Kargici, K, Tepe, M, Tatar, O, Kabadayi, E, Yildirim, A, Hurmuzlu, D, Korkmaz, K, Sharma, P, Troller, R, Hagan, N, Mooney, J, Light, A, Tansey, M, Bhojwani, D, Mcging, R, Mallon, A, Fadel, M, Spilsbury, C, James, R, O'Brien, S, Isaac, A, Balasubramanya, S, Sadik, H, Gala, T, Chen, J, Turner, B, Goh, E, Hassan, K, Karam, M, Mason, P, Tzoumas, N, Noton, T, Seehra, J, Ahmed, N, Motiwale, R, Tanna, V, Argyriou, A, Bylapudi, S, Grace, N, Latif, S, Hounat, A, Kiam, J, Zaidi, M, Elsamani, K, Hughes, C, Suresh, A, Sinan, L, El-Dalil, D, Khoo, E, Salim, E, Stark, D, Minhas, N, Fowler, G, Rees, E, Giudiceandrea, I, Bardon, A, Jayawardena, P, Dieseru, N, Murphy, A, Yates, C, Ziolkowska, K, Rafie, A, Khoda, F, Okocha, M, Ashdown, T, Vitish-Sharma, P, Gilliland, J, Toh, S, Jones, K, Devine, A, Berry, A, Mcdonnell, S, Olivier, J, Richardson, G, Lim, H, Slim, N, Elsayeh, K, Sammour, T, Sarpanov, A, Belev, N, Dimitrov, D, Dusek, T, Ntomi, V, Sotiropoulos, G, Theodorou, D, Nikiteas, N, Balalis, D, Antropoli, C, Altomare, D, Luglio, G, De Palma, G, Pedrazzani, C, Simonelli, L, Brozzetti, S, Porcu, A, Massani, M, Grazi, G, Izzo, F, Delrio, P, Restini, E, Chetta, G, Lantone, G, Ferrari, G, Lucchi, A, De Prizio, M, Caristo, G, Borghi, F, Petrucciani, N, Huscher, C, Cocorullo, G, Tonini, V, Medas, F, Sica, G, Cillara, N, Anastasi, A, Bianco, F, Giuliani, A, Carlini, M, Selvaggi, F, Sammarco, G, Ozolins, A, Malasonoks, A, Andrejevic, P, Tanis, P, van de Ven, A, Gerhards, M, Ribeiro da Silva, B, Silva, A, Lima, M, Kavanagh, D, Mccawley, N, Bintintan, V, Karamarkovic, A, Sanz Ortega, G, De Andres-Asenjo, B, Nevado Garcia, C, Garcia Florez, L, Segura-Sampedro, J, Blas Laina, J, Ponchietti, L, Buchwald, P, Gialamas, E, Ozben, V, Rencuzogullari, A, Gecim, I, Altinel, Y, Isik, O, Yoldas, T, Isik, A, Leventoglu, S, Erturk, M, Guner, A, Guler, S, Attaallah, W, Ugur, M, Ozbalci, G, Marzook, H, Eardley, N, Smolarek, S, Morgan, R, Roxburgh, C, Lala, A, Salama, Y, Singh, B, Khanna, A, Evans, M, Shaikh, I, Maradi Thippeswamy, K, Appleton, B, Moug, S, Smith, I, Smart, N, Shah, P, Williams, G, Khera, G, Goede, A, Varcada, M, Parmar, C, Duff, S, Hargest, R, Marriott, P, Speake, D, Ben Sassi, A, Furfaro, B, Daudu, D, Golijanin, N, Yek, W, Capasso, G, Mansour, L, Niu, N, Seow, W, Hamidovic, A, Kulovic, E, Letic, E, Aljic, A, Helez, M, Banji-Kelan, A, Dimitrova, N, Kavradjieva, P, Ivanov, V, Jukaku, A, Hadzhiev, D, Gabarski, A, Karamanliev, M, Vladova, P, Iliev, S, Yotsov, T, Epsilonupsilonsigmataualphathetaiotaomicronupsilon, E, Vetsa, K, Stavrinidou, O, Papatheodorou, P, Liassides, T, Georgiou, T, Al Nassrallah, M, Altaf, R, Negametzyanov, M, Zagibova, D, Foltys, F, Stefanova, H, Paspala, A, Bompetsi, G, Sidiropoulos, T, Stamopoulos, P, Triantafyllou, A, Theodoropoulos, C, Kimpizi, A, Palyvou, T, Charalabopoulos, A, Syllaios, A, Schizas, D, Liatsou, E, Baili, E, Vagios, I, Tomara, N, Davakis, S, Palumbo, A, Foroni, F, Dibra, R, Papagni, V, Urbani, A, Rossin, E, Nezi, G, Romano, P, Amendola, A, Esposito, E, Manigrasso, M, Anoldo, P, Vertaldi, S, Gecchele, G, Sabrina, Z, Guerci, C, Cammarata, F, Lamperti, G, Zaffaroni, G, Benuzzi, L, Ferrario, L, Cigognini, M, Mazzeo, C, Badessi, G, Pintabona, G, Fassari, A, Mingoli, A, Cirillo, B, D'Alterio, C, Brachini, G, Tancredi, M, Zambon, M, Aulicino, M, Sapienza, P, Liberatore, P, Scanu, A, Feo, C, Iacomino, A, Pelizzo, P, Rossi, S, Vigna, S, Grossi, U, Grillo, V, Agnes, A, Schena, C, Marincola, G, Oddi, A, Perotti, B, Mario, V, Perri, P, Zazza, S, Aversano, A, Scala, D, Di Lauro, K, Leongito, M, Piccirillo, M, Patrone, R, Capuzzolo, S, Vignotto, C, Bao, Q, Giuseppe, C, Angarano, E, Marino, F, Pezzolla, F, Gigante, G, Magistro, C, Crippa, J, Maspero, M, Carnevali, P, Trapani, R, Zonta, S, Agostinelli, L, Vittori, L, Romeo, L, Doria, E, Farnesi, F, Danna, R, Andolfi, E, Pellicano', G, Angelini, M, Scricciolo, M, Zanframundo, C, Ciulli, C, Ripamonti, L, Cigagna, L, Oldani, M, Larcinese, A, Rossi, D, Picone, E, Crescentini, G, Marano, A, Migliore, M, Giuffrida, M, Palagi, S, Testa, V, Borrello, A, Lucarini, A, Garofalo, E, Canali, G, Orlandi, P, Nervegna, F, Marchegiani, F, Damoli, I, Licata, A, Trovato, C, Alicata, F, Sardo, F, Milazzo, M, Randisi, B, Dominici, D, Sartarelli, L, Zanni, M, Pisanu, A, Soddu, C, Delogu, D, Erdas, E, Campus, F, Cappellacci, F, Casti, F, Marcialis, J, Atzeni, J, Sensi, B, Franceschilli, M, Bellato, V, Cannavera, A, Putzu, G, di Mola, F, Picardi, B, Solinas, L, Loponte, M, Rossi del Monte, S, Di Martino, C, Linari, C, Spagni, G, Capezzuoli, L, Tirloni, L, Nelli, T, Caridi, A, Elter, C, Camassa, M, D'Amico, S, Bargellini, T, Incollingo, P, Montuori, M, Maffione, F, Romano, L, Valiyeva, S, Spoletini, D, Menegon Tasselli, F, Sciaudone, G, Selvaggi, L, Menna, M, De Paola, G, Fulginiti, S, Truskovs, A, Weiss, C, Saknitis, G, Rauscher, J, Larnovskis, J, Jeyarajan-Davidsson, M, Nitisa, D, Gille, N, Reiser, S, Roshan, M, Leseman, C, van Dalen, A, Top, C, Detering, R, Matos, C, Silva, C, Pinto, D, Mendes, J, Couto, J, Leite, M, Velez, C, Damasio Cotovio, M, Cinza, A, Pedroso de Lima, R, Boyle, E, Yang, H, Banerjee, I, Rahmat, S, Afzal, Z, Reid, C, Dumitrascu, F, Croyle, J, Gressmann, K, Cullen, N, Graham, A, Nasehi, A, Montano King, C, Martin, B, Stokell, C, Sanderson, N, Farnan, R, Jassim, S, Chan, B, Chua Vi Long, K, Kaka, N, Pandey, S, Neo, W, Chitul, A, Bezede, C, Cincilei, D, David, A, Blaga, M, Blaga, S, Fagarasan, V, Khetagurova, M, Rodimov, S, Kapustina, A, Mekhralyzade, A, Zabiyaka, M, Jankovic, U, Cuk, V, Hajska, M, Dubovsky, M, Hrosova, M, Ferancikova, N, Camarero Rodriguez, E, Laguna Alcantara, F, Adarraga, J, Jezieniecki, C, Ruiz Soriano, M, Gomez Sanz, T, Suarez, A, Sanchez Garcia, C, Cifrian Canales, I, Llosa Perez, J, Merayo, M, Urbieta, A, Gegundez Simon, A, Tone, J, Gazo Martinez, J, Vicario Bravo, M, Chavarrias, N, Gil Catalan, A, Oseira, A, Villalonga, B, Jeri, S, Perez Calvo, J, Nogues, A, Cros, B, Yanez, C, Utrilla Fornals, A, Roldon Golet, M, Colsa, P, Gimenez Maurel, T, Axmarker, T, Chevallay, M, Pham, T, Sel, E, Atar, C, Aba, M, Sarkin, M, Akkaya, Y, Durmaz, A, Gullu, H, Boga, A, Aktas, A, Bakar, B, Demirel, M, Hysejni, X, Taser, M, Guzel, O, Bozbiyik, O, Ozen, D, Olmez, M, Uyar, B, Gulcek, E, Kayacan, G, Atici, N, Gul, O, Altiner, S, Ibis, B, Altunsu, S, Banaz, T, Diler, C, Demirbas, I, Usta, M, Erkul, O, Orman, R, Salih, S, Utkan, N, Acil, C, Ozgur, E, Maddahali, M, Turhan, A, Eskici, A, Ular, B, Dogru, M, Ozturk, O, Arslan, E, Panahi Sharif, A, Dikmen, E, Ates, J, Bircan, R, Cavus, T, Sever, A, Balak, B, Duman, E, Altay, L, Emanet, O, Cullen, F, Tan, J, Nathan, A, Rottenberg, A, Williams, C, Mitrofan, C, Xu, D, Bawa, J, Morris, P, Gordon, D, Richmond, G, Hui, J, Ighomereho, O, Rocks, R, Mccabe, S, Fitzpatrick, A, Nicoletti, J, Auterson, L, Darrah, N, Soh, V, Ong, C, Utukuri, M, Gallagher, C, Stuart, L, Hipolito, M, Douglas, N, Ghazal, R, Parris, G, Catchpole, J, Bryden, M, Jamal, S, Karim, Z, Lyon-Dean, C, Rowley, G, Lee, K, Whitehurst, O, Mirza, A, Sheikh, F, Yousaf, H, Bilbao, J, Sinclair, R, Takar, S, Kressel, H, Chan, V, Schack, K, Osborne, R, Baldemor, S, Smyth, S, Gilmour, S, Ting, A, Bozonelou, I, Saunders, P, Qhaireel Anwar, Q, Tirimanna, R, Jauhari, S, Gardener, A, Walker, B, Wenban, C, Reddy, H, Conway-Jones, R, Loganathan, S, Clynch, A, James, C, Matey, E, Cameron, F, Roberts, W, Gicquel, A, Milliken, C, Forbes, J, Rubinchik, P, Azmi, A, Hawkes, C, Cornett, L, Adarkwah, P, Mcconville, R, O'Hara, S, Tijare, C, Parkes, J, Yao, L, Ahmad, R, Shafiq, U, Mhaisalkar, A, Gurung, A, de Stadler, K, Elias, S, Thomas, T, Madras, A, Jani, A, Daler, H, Tong, K, Sundaralingam, S, Szal, A, Khan, A, O'Sullivan, C, Baker, E, Joseph-Gubral, J, Hadley, E, Trivedi, R, Igwelaezoh, E, Barton, H, Allison, W, Hurst, W, Alam, F, Parkes, I, Jamshaid, M, Azizan, N, Burgher, T, Afzal, A, Eltilib, I, Zahid, M, Sadiq, O, Lloyd, A, Ho, R, Brazukas, A, Li, C, Kamdar, M, Mohamed Nazeer, M, Mighiu, A, Kim, D, Wilkins, L, Kuo, L, Rafe, T, Maduka, D, Cheema, H, Farag, K, Abdellatif, M, Nzewi, R, Kruczynska, A, Grasselli, H, Yousuff, M, Bassi, R, Mann, A, Chopra, J, Shaikh, M, D Sa, S, Tsimplis, V, Ghanchi, A, Skene, E, Asim, K, Zaheer, M, Chan, S, Dalton, H, Gibbons, K, Adderley, O, Chukwujindu, I, Jayasuriya, I, Sivanu, K, Borumand, M, Chick, G, Bridges, I, Tomlin, J, Mckenna, J, Nandra, N, Grieco, C, Quek, F, Mercer, R, Brankin-Frisby, T, Sattar, A, Aslam, A, Edelsten, E, Shafi, S, Kouli, T, Ford, V, Gurung, F, Fernandes, M, Deader, N, Ponniah, R, Jamieson, S, Davies, A, Taubwurcel, J, Aung, M, Desai, R, Begum, S, Jamadar, T, Kangatharan, A, Rzeszowski, B, Ho, C, Yap, S, Prendergast, M, Sethi, R, Duku, A, Lowe, C, Bray, J, Ghobrial, M, Nichita, V, Wagstaff, A, Rengasamy, E, Abu Hassan, F, Mahmood, H, Savill, N, Shah, S, Almeida, T, Edwards, A, Catchpole, B, Halford, Z, Carmichael, A, Alsusa, H, Boyd, M, Williams, J, Feyi-Waboso, J, Patel, M, Zeidan, Z, Bailey, E, Bapty, J, Brazkiewicz, M, Tremlett, A, Pringle, H, Mankal, S, Chung, W, Parry-Jones, E, Anderson, K, Mcforrester, A, Stanley, A, Hoather, A, Wise, H, Laid, I, Scriven, J, Braniste, A, Wilson, A, Le Blevec, L, Pakunwanich, N, Evans, N, Chong, H, White, C, Hunter, J, Haque, M, Vanalia, P, Murdoch, S, Choudhary, T, Mccann, A, Harun, A, Shah, H, Hunt, S, Shafiq, Y, Bickley-Morris, E, Emms, L, Dare, M, Akula, Y, Deliyannis, E, Mayes, F, Ellacott, M, Zagorac, Z, Farren, A, Manning, C, Hughed, C, Stewart, E, Lim, K, 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K., Salama Y., Singh B., Khanna A., Evans M., Shaikh I., Maradi Thippeswamy K., Appleton B., Moug S., Smith I., Smart N., Shah P., Williams G., Khera G., Goede A., Varcada M., Parmar C., Duff S., Hargest R., Marriott P., Speake D., Ben Sassi A., Furfaro B., Daudu D., Golijanin N., Yek W. Y., Capasso G., Mansour L. T., Niu N., Seow W., Hamidovic A., Kulovic E., Letic E., Aljic A., Helez M., Banji-Kelan A., Dimitrova N., Kavradjieva P., Ivanov V., Jukaku A., Hadzhiev D., Gabarski A., Karamanliev M., Vladova P., Iliev S., Yotsov T., Epsilonupsilonsigmataualphathetaiotaomicronupsilon Eta., Vetsa K., Stavrinidou O., Papatheodorou P., Liassides T., Georgiou T., Al Nassrallah M., Altaf R., Negametzyanov M., Zagibova D., Foltys F., Stefanova H., Paspala A., Bompetsi G., Sidiropoulos T., Stamopoulos P., Triantafyllou A., Theodoropoulos C., Kimpizi A., Palyvou T., Charalabopoulos A., Syllaios A., Schizas D., Liatsou E., Baili E., Vagios I., Tomara N., Davakis S., Palumbo A., Foroni F., Dibra R., Papagni V., Urbani A., Rossin E., Nezi G., Romano P., Amendola A., Esposito E., Manigrasso M., Anoldo P., Vertaldi S., Gecchele G., Sabrina Z. S., Guerci C., Cammarata F., Lamperti G. M. B., Zaffaroni G., Benuzzi L., Ferrario L., Cigognini M., Mazzeo C., Badessi G., Pintabona G., Fassari A., Mingoli A., Cirillo B., D'Alterio C., Brachini G., Tancredi M., Zambon M., Aulicino M., Sapienza P., Liberatore P., Scanu A. M., Feo C. F., Iacomino A., Pelizzo P., Rossi S., Vigna S. A., Grossi U., Grillo V., Agnes A., Schena C. A., Marincola G., Oddi A., Perotti B., Mario V., Perri P., Zazza S., Aversano A., Scala D., Di Lauro K., Leongito M., Piccirillo M., Patrone R., Capuzzolo S., Vignotto C., Bao Q. R., Giuseppe C., Angarano E., Marino F., Pezzolla F., Gigante G., Magistro C., Crippa J., Maspero M., Carnevali P., Trapani R., Zonta S., Agostinelli L., Vittori L., Romeo L., Doria E., Farnesi F., Danna R., Andolfi E., Pellicano' G. A., Angelini M., Scricciolo M., Zanframundo C., Ciulli C., Ripamonti L., Cigagna L., Oldani M., Larcinese A., Rossi D., Picone E., Crescentini G., Marano A., Migliore M., Giuffrida M. 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F., Gazo Martinez J., Vicario Bravo M., Chavarrias N., Gil Catalan A., Oseira A., Villalonga B., Jeri S., Perez Calvo J., Nogues A., Cros B., Yanez C., Utrilla Fornals A., Roldon Golet M., Colsa P., Gimenez Maurel T., Axmarker T., Chevallay M., Pham T. V., Sel E. K., Atar C., Aba M., Sarkin M., Akkaya Y. M., Durmaz A. G., Gullu H. F., Boga A., Aktas A., Bakar B., Demirel M. T., Hysejni X., Taser M., Guzel O. R., Bozbiyik O., Ozen D., Olmez M., Uyar B., Gulcek E., Kayacan G. S., Atici N., Gul O. F., Altiner S., Ibis B., Altunsu S., Banaz T., Diler C., Demirbas I., Usta M. A., Erkul O., Orman R., Salih S., Utkan N. Z., Acil C., Ozgur E., Maddahali M., Turhan A. B., Eskici A. B., Ular B., Dogru M., Ozturk O. U., Arslan E. R., Panahi Sharif A., Dikmen E., Ates J., Bircan R., Cavus T., Sever A. E., Balak B., Duman E., Altay L., Emanet O., Cullen F., Tan J. Y., Nathan A., Rottenberg A., Williams C. Y., Mitrofan C. G., Xu D., Bawa J. H., Morris P., Gordon D., Richmond G., Hui J. 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S., Szal A., Khan A., O'Sullivan C., Baker E., Joseph-Gubral J., Hadley E., Trivedi R., Igwelaezoh E., Barton H., Allison W., Hurst W., Alam F., Parkes I., Jamshaid M., Azizan N., Burgher T., Afzal A., Eltilib I., Zahid M., Sadiq O., Lloyd A., Ho R., Brazukas A., Li C. H., Kamdar M., Mohamed Nazeer M. N., Mighiu A., Kim D., Wilkins L., Kuo L., Rafe T., Maduka D., Cheema H., Farag K., Abdellatif M., Nzewi R., Kruczynska A., Grasselli H., Yousuff M., Bassi R., Mann A. K., Chopra J., Shaikh M., D Sa S., Tsimplis V., Ghanchi A., Skene E., Asim K., Zaheer M., Chan S., Dalton H., Gibbons K., Adderley O., Chukwujindu I., Jayasuriya I., Sivanu K., Borumand M., Chick G., Bridges I., Tomlin J., McKenna J., Nandra N., Grieco C., Quek F. F., Mercer R., Brankin-Frisby T., Sattar A., Aslam A., Edelsten E., Shafi S., Kouli T., Ford V., Gurung F., Fernandes M., Deader N., Ponniah R., Jamieson S., Davies A., Taubwurcel J., Aung M. T., Desai R., Begum S., Jamadar T., Kangatharan A., Rzeszowski B., Ho C., Yap S. H. K., Prendergast M., Sethi R., Duku A., Lowe C., Bray J., Ghobrial M., Nichita V., Wagstaff A., Rengasamy E., Abu Hassan F., Mahmood H., Savill N., Shah S., Almeida T., Edwards A., Catchpole B., Halford Z., Carmichael A., Alsusa H., Boyd M., Williams J., Feyi-Waboso J., Patel M., Zeidan Z., Bailey E., Bapty J., Brazkiewicz M., Tremlett A., Pringle H., Mankal S., Chung W., Parry-Jones E., Anderson K., Mcforrester A., Stanley A., Hoather A., Wise H., Laid I., Scriven J., Braniste A., Wilson A., Le Blevec L., Pakunwanich N., Evans N., Chong H. L., White C., Hunter J., Haque M., Vanalia P., Murdoch S., Choudhary T., McCann A., Harun A., Shah H., Hunt S., Shafiq Y., Bickley-Morris E., Emms L., Dare M., Akula Y., Deliyannis E., Mayes F., Ellacott M., Zagorac Z., Farren A., Manning C., Hughed C., Stewart E. G., Lim K. H., Chohan N., Thaker A., Thompson B., Ahari D., Burdekin E., Okwu U., Akintunde A., Lhaf F., Douthwaite J., Govindan R., Leelamanthep S., Gull E., Wright F., Dundas L., Mackdermott N., Burchi-Khairy T., Campbell I., Walsh J., Yeo J. Y., Meehan S., Banerjee D., Fu M., Kawka M., Ali T., Hussain Z., Thomas C., Ahmad H., Moroney J., Yick C., Risquet R., Ntuiabane D., Shimato M., Khan M., Ilangovan S., Vaselli N. M., Smithers R., Uhanowita Marage R., Valnarov-Boulter A., Kayran J., Banerjee M., Parekh-Hill N., Hooper A., Bowen J., Jagdish R., Mcquoid C., Khan N., O Hare R., Jeffery S., Zahid A., Elsworth C., Walter L., Dhillon S., Rao S., Anthony A., Ashaye A., Phillips N., Faderani R., Pengelly S., Choi S., Kwak S. Y., Lau Y. H. L., Bagheri K., Ong D. Y. C., Kerr E., Falconer K., Clancy N., Douglas S., Zhang Y., Greenfield F., Mutanga I., McAlinden J., Willis L., Adefolaju A., Agarwal H., Barter R., Harris G., Spencer G., Lee M. 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H., Mannion P., Lovett A., Kincius A., Hussein S., Kirby E., Beckett R. G., Salmon J., Glynn T., Choo S. 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Toh, W, Mannion, P, Lovett, A, Kincius, A, Hussein, S, Kirby, E, Beckett, R, Salmon, J, Glynn, T, Choo, S, Lyons, S, Browne, D, Ravindran, W, Ahmad, S, Zhu, X, Mcnulty, J, Mccarthy, L, Ng, J, Karmally, Z, Mcteir, K, Hanna, M, Tan, E, Namdeo, S, Schembri, R, Pusey, E, Sgro A., Blanco-Colino R., Ahmed W. 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B., Zaffaroni G., Benuzzi L., Ferrario L., Cigognini M., Mazzeo C., Badessi G., Pintabona G., Fassari A., Mingoli A., Cirillo B., D'Alterio C., Brachini G., Tancredi M., Zambon M., Aulicino M., Sapienza P., Liberatore P., Scanu A. M., Feo C. F., Iacomino A., Pelizzo P., Rossi S., Vigna S. A., Grossi U., Grillo V., Agnes A., Schena C. A., Marincola G., Oddi A., Perotti B., Mario V., Perri P., Zazza S., Aversano A., Scala D., Di Lauro K., Leongito M., Piccirillo M., Patrone R., Capuzzolo S., Vignotto C., Bao Q. R., Giuseppe C., Angarano E., Marino F., Pezzolla F., Gigante G., Magistro C., Crippa J., Maspero M., Carnevali P., Trapani R., Zonta S., Agostinelli L., Vittori L., Romeo L., Doria E., Farnesi F., Danna R., Andolfi E., Pellicano' G. A., Angelini M., Scricciolo M., Zanframundo C., Ciulli C., Ripamonti L., Cigagna L., Oldani M., Larcinese A., Rossi D., Picone E., Crescentini G., Marano A., Migliore M., Giuffrida M. C., Palagi S., Testa V., Borrello A., Lucarini A., Garofalo E., Canali G., Orlandi P., Nervegna F., Marchegiani F., Damoli I., Licata A., Trovato C., Alicata F., Sardo F., Milazzo M., Randisi B., Dominici D. M., Sartarelli L., Zanni M., Pisanu A., Soddu C., Delogu D., Erdas E., Campus F., Cappellacci F., Casti F., Marcialis J., Atzeni J., Podda M. G., Sensi B., Franceschilli M., Bellato V., Cannavera A., Putzu G., di Mola F. F., Picardi B., Solinas L., Loponte M., Rossi del Monte S., Di Martino C., Linari C., Spagni G., Capezzuoli L., Tirloni L., Nelli T., Caridi A., Elter C., Camassa M., D'Amico S., Bargellini T., Incollingo P., Montuori M., Maffione F., Romano L., Valiyeva S., Spoletini D., Menegon Tasselli F., Sciaudone G., Selvaggi L., Menna M. P., De Paola G., Fulginiti S., Truskovs A., Weiss C., Saknitis G., Rauscher J. T. R., Larnovskis J., Jeyarajan-Davidsson M., Nitisa D., Gille N., Reiser S. C., Roshan M. H. K., Leseman C., Chen J., van Dalen A. S., Top C., Detering R., Matos C., Silva C., Pinto D., Mendes J., Couto J., Leite M., Velez C., Damasio Cotovio M., Cinza A. M., Pedroso de Lima R., Boyle E., Yang H. W., Banerjee I., Rahmat S., Afzal Z., Reid C., Dumitrascu F., Croyle J. A., Gressmann K., Cullen N., Graham A., Nasehi A., Montano King C., Martin B., Stokell C., Sanderson N., Farnan R., Jassim S., Chan B., Chua Vi Long K., Kaka N., Pandey S., Neo W. X., Chitul A., Bezede C., Cincilei D., David A., Blaga M., Blaga S. N., Fagarasan V., Khetagurova M., Rodimov S., Kapustina A., Mekhralyzade A., Zabiyaka M., Jankovic U., Cuk V., Hajska M., Dubovsky M., Hrosova M., Ferancikova N., Camarero Rodriguez E., Laguna Alcantara F., Adarraga J., Jezieniecki C., Ruiz Soriano M., Gomez Sanz T., Suarez A., Sanchez Garcia C., Cifrian Canales I., Llosa Perez J., Merayo M., Urbieta A., Gegundez Simon A., Tone J. F., Gazo Martinez J., Vicario Bravo M., Chavarrias N., Gil Catalan A., Oseira A., Villalonga B., Jeri S., Perez Calvo J., Nogues A., Cros B., Yanez C., Utrilla Fornals A., Roldon Golet M., Colsa P., Gimenez Maurel T., Axmarker T., Chevallay M., Pham T. V., Sel E. K., Atar C., Aba M., Sarkin M., Akkaya Y. M., Durmaz A. G., Gullu H. F., Boga A., Aktas A., Bakar B., Demirel M. T., Hysejni X., Taser M., Guzel O. R., Bozbiyik O., Ozen D., Olmez M., Uyar B., Gulcek E., Kayacan G. S., Atici N., Gul O. F., Altiner S., Ibis B., Altunsu S., Banaz T., Diler C., Demirbas I., Usta M. A., Erkul O., Orman R., Salih S., Utkan N. Z., Acil C., Ozgur E., Maddahali M., Turhan A. B., Eskici A. B., Ular B., Dogru M., Ozturk O. U., Arslan E. R., Panahi Sharif A., Dikmen E., Ates J., Bircan R., Cavus T., Sever A. E., Balak B., Duman E., Altay L., Emanet O., Cullen F., Tan J. Y., Nathan A., Rottenberg A., Williams C. Y., Mitrofan C. G., Xu D., Bawa J. H., Morris P., Gordon D., Richmond G., Hui J. C., Ighomereho O., Rocks R., McCabe S., Fitzpatrick A., Nicoletti J., Auterson L., Darrah N., Soh V. W. Y., Ong C. S., Utukuri M., Gallagher C., Stuart L. M., Hipolito M., Douglas N., Ghazal R., Parris G., Catchpole J., Bryden M., Jamal S., Karim Z., Lyon-Dean C., Rowley G., Lee K. S., Whitehurst O., Mirza A., Sheikh F., Yousaf H., Bilbao J., Sinclair R., Takar S., Kressel H., Chan V., Schack K., Osborne R., Baldemor S., Smyth S., Gilmour S., Ting A., Bozonelou I., Saunders P., Qhaireel Anwar Q. A., Tirimanna R., Jauhari S., Gardener A., Walker B., Wenban C., Reddy H., Conway-Jones R., Loganathan S., Clynch A., James C., Matey E., Cameron F., Roberts W., Gicquel A., Milliken C., Forbes J., Rubinchik P., Azmi A., Hawkes C., Cornett L., Adarkwah P., McConville R., O'Hara S., Tijare C., Parkes J., Yao L., Ahmad R., Shafiq U., Mhaisalkar A., Gurung A., de Stadler K., Elias S., Thomas T., Madras A., Jani A., Daler H. K., Tong K. S., Sundaralingam S. S., Szal A., Khan A., O'Sullivan C., Baker E., Joseph-Gubral J., Hadley E., Trivedi R., Igwelaezoh E., Barton H., Allison W., Hurst W., Alam F., Parkes I., Jamshaid M., Azizan N., Burgher T., Afzal A., Eltilib I., Zahid M., Sadiq O., Lloyd A., Ho R., Brazukas A., Li C. H., Kamdar M., Mohamed Nazeer M. N., Mighiu A., Kim D., Wilkins L., Kuo L., Rafe T., Maduka D., Cheema H., Farag K., Abdellatif M., Nzewi R., Kruczynska A., Grasselli H., Yousuff M., Bassi R., Mann A. K., Chopra J., Shaikh M., D Sa S., Tsimplis V., Ghanchi A., Skene E., Asim K., Zaheer M., Chan S., Dalton H., Gibbons K., Adderley O., Chukwujindu I., Jayasuriya I., Sivanu K., Borumand M., Chick G., Bridges I., Tomlin J., McKenna J., Nandra N., Grieco C., Quek F. F., Mercer R., Brankin-Frisby T., Sattar A., Aslam A., Edelsten E., Shafi S., Kouli T., Ford V., Gurung F., Fernandes M., Deader N., Ponniah R., Jamieson S., Davies A., Taubwurcel J., Aung M. T., Desai R., Begum S., Jamadar T., Kangatharan A., Rzeszowski B., Ho C., Yap S. H. K., Prendergast M., Sethi R., Duku A., Lowe C., Bray J., Ghobrial M., Nichita V., Wagstaff A., Rengasamy E., Abu Hassan F., Mahmood H., Savill N., Shah S., Almeida T., Edwards A., Catchpole B., Halford Z., Carmichael A., Alsusa H., Boyd M., Williams J., Feyi-Waboso J., Patel M., Zeidan Z., Bailey E., Bapty J., Brazkiewicz M., Tremlett A., Pringle H., Mankal S., Chung W., Parry-Jones E., Anderson K., Mcforrester A., Stanley A., Hoather A., Wise H., Laid I., Scriven J., Braniste A., Wilson A., Le Blevec L., Pakunwanich N., Evans N., Chong H. L., White C., Hunter J., Haque M., Vanalia P., Murdoch S., Choudhary T., McCann A., Harun A., Shah H., Hunt S., Shafiq Y., Bickley-Morris E., Emms L., Dare M., Akula Y., Deliyannis E., Mayes F., Ellacott M., Zagorac Z., Farren A., Manning C., Hughed C., Stewart E. G., Lim K. H., Chohan N., Thaker A., Thompson B., Ahari D., Burdekin E., Okwu U., Akintunde A., Lhaf F., Douthwaite J., Govindan R., Leelamanthep S., Gull E., Wright F., Dundas L., Mackdermott N., Burchi-Khairy T., Campbell I., Walsh J., Yeo J. Y., Meehan S., Banerjee D., Fu M., Kawka M., Ali T., Hussain Z., Thomas C., Ahmad H., Moroney J., Yick C., Risquet R., Ntuiabane D., Shimato M., Khan M., Ilangovan S., Vaselli N. M., Smithers R., Uhanowita Marage R., Valnarov-Boulter A., Kayran J., Banerjee M., Parekh-Hill N., Hooper A., Bowen J., Jagdish R., Mcquoid C., Khan N., O Hare R., Jeffery S., Zahid A., Elsworth C., Walter L., Dhillon S., Rao S., Anthony A., Ashaye A., Phillips N., Faderani R., Pengelly S., Choi S., Kwak S. Y., Lau Y. H. L., Bagheri K., Ong D. Y. C., Kerr E., Falconer K., Clancy N., Douglas S., Zhang Y., Greenfield F., Mutanga I., McAlinden J., Willis L., Adefolaju A., Agarwal H., Barter R., Harris G., Spencer G., Lee M. 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A., Kurtenkov M., Jovanovic M., Vician M., Egea Arias P., Beltran de Heredia J., Labalde Martinez M., De Santiago Alvarez I., Alvarez-Gallego M., Rodriguez Artigas J. M., Dwidar O., Korkmaz H. K., Eray I. C., Meric S., Aydin R., Cetin B., Karaca B. E., Kuyumcu O. F., Yuksel E., Uprak T. K., Karabulut K., Kavukcu E., Mansor A., Hackett R., Zammit-Maempel M., Sabaratnam R., Maan A., Ferarrio I., Dixon L., Halai H., Sethi S., Nelson L., Grassam-rowe A., Krishnan E., Deeny D., McKeever M., George Pandeth A., Dhavala P., Sreenivasan S., Sundaram Venkatesan G., Zhu L., Atiyah Z., Gregory J., Morey T., Seymour Z., Holdsworth L., Abdelmahmoud S., Bourhill J., Bisheet G., Shaw J., Kulkarni K., Kumarakulasingam P., Pillay S., Al-Habsi R., Kungwengwe G., Richards J., Davoudi K., Ibrahim B., Tailor B., Zayed M., Chen F., Bailey S., Sheefat S., Nawaz G., Pawar R., Marsh S., Sam Z. H., Roy Bentley S., Simpson C., Hughes J., Lim Y., Ooi R., Toh W. H., Mannion P., Lovett A., Kincius A., Hussein S., Kirby E., Beckett R. G., Salmon J., Glynn T., Choo S. Y., Lyons S., Browne D., Ravindran W., Ahmad S., Zhu X., McNulty J., McCarthy L., Ng J., Karmally Z., McTeir K., Hanna M., Tan E., Namdeo S., Schembri R., and Pusey E.
- Abstract
Aim: Intraperitoneal drains are often placed during emergency colorectal surgery. However, there is a lack of evidence supporting their use. This study aimed to describe the efficacy and safety of intraperitoneal drain placement after emergency colorectal surgery. Method: COMPlicAted intra-abdominal collectionS after colorectal Surgery (COMPASS) is a prospective, international, cohort study into which consecutive adult patients undergoing emergency colorectal surgery were enrolled (from 3 February 2020 to 8 March 2020). The primary outcome was the rate of intraperitoneal drain placement. Secondary outcomes included rate and time-to-diagnosis of postoperative intraperitoneal collections, rate of surgical site infections (SSIs), time to discharge and 30-day major postoperative complications (Clavien–Dindo III–V). Multivariable logistic and Cox proportional hazards regressions were used to estimate the independent association of the outcomes with drain placement. Results: Some 725 patients (median age 68.0 years; 349 [48.1%] women) from 22 countries were included. The drain insertion rate was 53.7% (389 patients). Following multivariable adjustment, drains were not significantly associated with reduced rates (odds ratio [OR] = 1.56, 95% CI: 0.48–5.02, p = 0.457) or earlier detection (hazard ratio [HR] = 1.07, 95% CI: 0.61–1.90, p = 0.805) of collections. Drains were not significantly associated with worse major postoperative complications (OR = 1.26, 95% CI: 0.67–2.36, p = 0.478), delayed hospital discharge (HR = 1.11, 95% CI: 0.91–1.36, p = 0.303) or increased risk of SSIs (OR = 1.61, 95% CI: 0.87–2.99, p = 0.128). Conclusion: This is the first study investigating placement of intraperitoneal drains following emergency colorectal surgery. The safety and clinical benefit of drains remain uncertain. Equipoise exists for randomized trials to define the safety and efficacy of drains in emergency colorectal surgery.
- Published
- 2023
360. The increased neopterin content in turkish pediatric patients with sickle cell anemia
- Author
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Sabuncuoğlu, Suna, Öztaş, Yeşim, Yalcinkaya, Ahmet, Ünal, Selma, Baydar, Terken, and Girgin, Gözde
- Published
- 2020
- Full Text
- View/download PDF
361. Electrospun Polyamide-6 Nanofiber Hybrid Membranes for Wastewater Treatment
- Author
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Yalcinkaya, Fatma, Yalcinkaya, Baturalp, and Hruza, Jakub
- Published
- 2019
- Full Text
- View/download PDF
362. RE: Proximal bulbar periurethral abscess
- Author
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Tokgoz, Husnu, Soyuncu, Ilkay, Yalcinkaya, Soner, Tokgoz, Ozlem, and Savas, Murat
- Subjects
Abscess ,Humans ,Male ,Radiography ,Urethral Diseases ,Urology & Nephrology - Published
- 2015
363. Fifty shades of black
- Author
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Borovik, Alexandre and Yalçınkaya, Şükrü
- Subjects
Mathematics - Group Theory ,Primary 20P05, Secondary 03C65 - Abstract
The paper proposes a new and systematic approach to the so-called black box group methods in computational group theory. As the starting point of our programme, we construct Frobenius maps on black box groups of untwisted Lie type in odd characteristic and then apply them to black box groups X encrypting groups (P)SL(2,q) in small odd characteristics. We propose an algorithm constructing a black box field K isomorphic to F_q, and an isomorphism from (P)SL(2,K) to X. The algorithm runs in time quadratic in the characteristic of the underlying field and polynomial in log q. Due to the nature of our work we also have to discuss a few methodological issues of the black box group theory., Comment: 23 pages, 1 figure
- Published
- 2013
364. Steinberg presentations of black box classical groups in small characteristics
- Author
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Borovik, Alexandre and Yalcinkaya, Sukru
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Mathematics - Group Theory - Abstract
The main component of (constructive) recognition algorithms for black box groups of Lie type in computational group theory is the construction of unipotent elements. In the existing algorithms unipotent elements are found by random search and therefore the running time of these algorithms is polynomial in the underlying field size $q$ which makes them unfeasible for most practical applications \cite{guralnick01.169}. Meanwhile, the input size of recognition algorithms involves only $\log q$. The present paper introduces a new approach to construction of unipotent elements in which the running time of the algorithm is quadratic in characteristic $p$ of the underlying field and is polynomial in $\log q$; for small values of $p$ (which make a vast and practically important class of problems), the complexity of these algorithms is polynomial in the input size. For $\psl_2(q)$, $\qpone$, we present a Monte-Carlo algorithm which constructs a root subgroup $U$, the maximal torus $T$ normalizing $U$ and a Weyl group element $w$ which conjugates $U$ to its opposite. Moreover, we extend this result and construct Steinberg generators for the black box untwisted classical groups defined over a field of odd size $q=p^k$ where $\qpone$. Our algorithms run in time quadratic in characteristic $p$ of the underlying field and polynomial in $\log q$ and the Lie rank $n$ of the group. The case $\qmone$ requires the use of additional tools and is treated separately in our next paper \cite{suko12B}. Further, and much stronger results can be found in \cite{suko12E,suko12F}.
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- 2013
365. Multiscale modelling for fusion and fission materials: The M4F project
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L. Malerba, M.J. Caturla, E. Gaganidze, C. Kaden, M.J. Konstantinović, P. Olsson, C. Robertson, D. Rodney, A.M. Ruiz-Moreno, M. Serrano, J. Aktaa, N. Anento, S. Austin, A. Bakaev, J.P. Balbuena, F. Bergner, F. Boioli, M. Boleininger, G. Bonny, N. Castin, J.B.J. Chapman, P. Chekhonin, M. Clozel, B. Devincre, L. Dupuy, G. Diego, S.L. Dudarev, C.-C. Fu, R. Gatti, L. Gélébart, B. Gómez-Ferrer, D. Gonçalves, C. Guerrero, P.M. Gueye, P. Hähner, S.P. Hannula, Q. Hayat, M. Hernández-Mayoral, J. Jagielski, N. Jennett, F. Jiménez, G. Kapoor, A. Kraych, T. Khvan, L. Kurpaska, A. Kuronen, N. Kvashin, O. Libera, P.-W. Ma, T. Manninen, M.-C. Marinica, S. Merino, E. Meslin, F. Mompiou, F. Mota, H. Namburi, C.J. Ortiz, C. Pareige, M. Prester, R.R. Rajakrishnan, M. Sauzay, A. Serra, I. Simonovski, F. Soisson, P. Spätig, D. Tanguy, D. Terentyev, M. Trebala, M. Trochet, A. Ulbricht, M.Vallet, K. Vogel, T. Yalcinkaya, and J. Zhao
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Nuclear engineering. Atomic power ,TK9001-9401 - Abstract
The M4F project brings together the fusion and fission materials communities working on the prediction of radiation damage production and evolution and their effects on the mechanical behaviour of irradiated ferritic/martensitic (F/M) steels. It is a multidisciplinary project in which several different experimental and computational materials science tools are integrated to understand and model the complex phenomena associated with the formation and evolution of irradiation induced defects and their effects on the macroscopic behaviour of the target materials. In particular the project focuses on two specific aspects: (1) To develop physical understanding and predictive models of the origin and consequences of localised deformation under irradiation in F/M steels; (2) To develop good practices and possibly advance towards the definition of protocols for the use of ion irradiation as a tool to evaluate radiation effects on materials. Nineteen modelling codes across different scales are being used and developed and an experimental validation programme based on the examination of materials irradiated with neutrons and ions is being carried out. The project enters now its 4th year and is close to delivering high-quality results. This paper overviews the work performed so far within the project, highlighting its impact for fission and fusion materials science.
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- 2021
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366. Bile acid-independent protection against Clostridioides difficile infection.
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Andrea Martinez Aguirre, Nazli Yalcinkaya, Qinglong Wu, Alton Swennes, Mary Elizabeth Tessier, Paul Roberts, Fabio Miyajima, Tor Savidge, and Joseph A Sorg
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Immunologic diseases. Allergy ,RC581-607 ,Biology (General) ,QH301-705.5 - Abstract
Clostridioides difficile infections occur upon ecological / metabolic disruptions to the normal colonic microbiota, commonly due to broad-spectrum antibiotic use. Metabolism of bile acids through a 7α-dehydroxylation pathway found in select members of the healthy microbiota is regarded to be the protective mechanism by which C. difficile is excluded. These 7α-dehydroxylated secondary bile acids are highly toxic to C. difficile vegetative growth, and antibiotic treatment abolishes the bacteria that perform this metabolism. However, the data that supports the hypothesis that secondary bile acids protect against C. difficile infection is supported only by in vitro data and correlative studies. Here we show that bacteria that 7α-dehydroxylate primary bile acids protect against C. difficile infection in a bile acid-independent manner. We monoassociated germ-free, wildtype or Cyp8b1-/- (cholic acid-deficient) mutant mice and infected them with C. difficile spores. We show that 7α-dehydroxylation (i.e., secondary bile acid generation) is dispensable for protection against C. difficile infection and provide evidence that Stickland metabolism by these organisms consumes nutrients essential for C. difficile growth. Our findings indicate secondary bile acid production by the microbiome is a useful biomarker for a C. difficile-resistant environment but the microbiome protects against C. difficile infection in bile acid-independent mechanisms.
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- 2021
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367. Wide area scanning Trap Camera System with multi-cameras and distinctive motion detection sensor.
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Murat Simsek, Fikret Yalcinkaya, and Rifat Ugurlutan
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- 2018
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368. Modulation of the NLRP3 inflammasome by Sars-CoV-2 Envelope protein
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Yalcinkaya, Mustafa, Liu, Wenli, Islam, Mohammad N., Kotini, Andriana G., Gusarova, Galina A., Fidler, Trevor P., Papapetrou, Eirini P., Bhattacharya, Jahar, Wang, Nan, and Tall, Alan R.
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- 2021
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369. Variations in seasonal solar insolation are associated with a history of suicide attempts in bipolar I disorder
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Bauer, Michael, Glenn, Tasha, Achtyes, Eric D., Alda, Martin, Agaoglu, Esen, Altınbaş, Kürşat, Andreassen, Ole A., Angelopoulos, Elias, Ardau, Raffaella, Vares, Edgar Arrua, Aydin, Memduha, Ayhan, Yavuz, Baethge, Christopher, Bauer, Rita, Baune, Bernhard T., Balaban, Ceylan, Becerra-Palars, Claudia, Behere, Aniruddh P., Behere, Prakash B., Belete, Habte, Belete, Tilahun, Belizario, Gabriel Okawa, Bellivier, Frank, Belmaker, Robert H., Benedetti, Francesco, Berk, Michael, Bersudsky, Yuly, Bicakci, Şule, Birabwa-Oketcho, Harriet, Bjella, Thomas D., Brady, Conan, Cabrera, Jorge, Cappucciati, Marco, Castro, Angela Marianne Paredes, Chen, Wei-Ling, Cheung, Eric Y. Wo, Chiesa, Silvia, Crowe, Marie, Cuomo, Alessandro, Dallaspezia, Sara, Del Zompo, Maria, Desai, Pratikkumar, Dodd, Seetal, Donix, Markus, Etain, Bruno, Fagiolini, Andrea, Fellendorf, Frederike T., Ferensztajn-Rochowiak, Ewa, Fiedorowicz, Jess G., Fountoulakis, Kostas N., Frye, Mark A., Geoffroy, Pierre A., Gonzalez-Pinto, Ana, Gottlieb, John F., Grof, Paul, Haarman, Bartholomeus C. M., Harima, Hirohiko, Hasse-Sousa, Mathias, Henry, Chantal, Høffding, Lone, Houenou, Josselin, Imbesi, Massimiliano, Isometsä, Erkki T., Ivkovic, Maja, Janno, Sven, Johnsen, Simon, Kapczinski, Flávio, Karakatsoulis, Gregory N., Kardell, Mathias, Kessing, Lars Vedel, Kim, Seong Jae, König, Barbara, Kot, Timur L., Koval, Michael, Kunz, Mauricio, Lafer, Beny, Landén, Mikael, Larsen, Erik R., Lenger, Melanie, Lewitzka, Ute, Licht, Rasmus W., Lopez-Jaramillo, Carlos, MacKenzie, Alan, Madsen, Helle Østergaard, Madsen, Simone Alberte Kongstad A., Mahadevan, Jayant, Mahardika, Agustine, Manchia, Mirko, Marsh, Wendy, Martinez-Cengotitabengoa, Monica, Martiny, Klaus, Mashima, Yuki, McLoughlin, Declan M., Meesters, Ybe, Melle, Ingrid, Meza-Urzúa, Fátima, Ming, Mok Yee, Monteith, Scott, Moorthy, Muthukumaran, Morken, Gunnar, Mosca, Enrica, Mozzhegorov, Anton A., Munoz, Rodrigo, Mythri, Starlin V., Nacef, Fethi, Nadella, Ravi K., Nakanotani, Takako, Nielsen, René Ernst, O‘Donovan, Claire, Omrani, Adel, Osher, Yamima, Ouali, Uta, Pantovic-Stefanovic, Maja, Pariwatcharakul, Pornjira, Petite, Joanne, Pfennig, Andrea, Ruiz, Yolanda Pica, Pilhatsch, Maximilian, Pinna, Marco, Pompili, Maurizio, Porter, Richard, Quiroz, Danilo, Rabelo-da-Ponte, Francisco Diego, Ramesar, Raj, Rasgon, Natalie, Ratta-apha, Woraphat, Ratzenhofer, Michaela, Redahan, Maria, Reddy, M. S., Reif, Andreas, Reininghaus, Eva Z., Richards, Jenny Gringer, Ritter, Philipp, Rybakowski, Janusz K., Sathyaputri, Leela, Scippa, Ângela M., Simhandl, Christian, Severus, Emanuel, Smith, Daniel, Smith, José, Stackhouse, Jr., Paul W., Stein, Dan J., Stilwell, Kellen, Strejilevich, Sergio, Su, Kuan-Pin, Subramaniam, Mythily, Sulaiman, Ahmad Hatim, Suominen, Kirsi, Tanra, Andi J., Tatebayashi, Yoshitaka, Teh, Wen Lin, Tondo, Leonardo, Torrent, Carla, Tuinstra, Daniel, Uchida, Takahito, Vaaler, Arne E., Veeh, Julia, Vieta, Eduard, Viswanath, Biju, Yoldi-Negrete, Maria, Yalcinkaya, Oguz Kaan, Young, Allan H., Zgueb, Yosra, and Whybrow, Peter C.
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- 2021
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370. Extracellular microRNAs: key players to explore the outcomes of in vitro fertilization
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Khan, Haroon Latif, Bhatti, Shahzad, Abbas, Sana, Kaloglu, Celal, Isa, Ahmed M., Younas, Hooria, Ziders, Rachel, Khan, Yousaf Latif, Hassan, Zahira, Turhan, Bilgün Oztürk, Yildiz, Aysegul, Aydin, Hikmet Hakan, and Kalyan, Ender Yalcinkaya
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- 2021
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371. Preparation of various nanofiber layers using wire electrospinning system
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Yalcinkaya, Fatma
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- 2019
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372. Developmental Outcomes of Extremely Preterm Infants with a Need for Child Protective Services Supervision
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Polin, Richard A., Laptook, Abbott R., Keszler, Martin, Hensman, Angelita M., Alksninis, Barbara, Basso, Kristin M., Burke, Robert, Caskey, Melinda, Johnson, Katharine, Keszler, Mary Lenore, Knoll, Andrea M., Leach, Theresa M., Little, Emilee, McGowan, Elisabeth C., Vieira, Elisa, Watson, Victoria E., Ventura, Suzy, Walsh, Michele C., Fanaroff, Avroy A., Hibbs, Anna Marie, Wilson-Costello, Deanne E., Newman, Nancy S., Payne, Allison H., Siner, Bonnie S., Bhola, Monika, Yalcinkaya, Gulgun, Friedman, Harriet G., Truog, William E., Pallotto, Eugenia K., Kilbride, Howard W., Gauldin, Cheri, Holmes, Anne, Johnson, Kathy, Knutson, Allison, Schibler, Kurt, Donovan, Edward F., Grisby, Cathy, Bridges, Kate, Alexander, Barbara, Fischer, Estelle E., Mincey, Holly L., Hessling, Jody, Gratton, Teresa L., Jackson, Lenora, Kirker, Kristin, Muthig, Greg, Steichen, Jean J., Tepe, Stacey, Yolton, Kimberly, Goldberg, Ronald N., Cotten, C. Michael, Goldstein, Ricki F., Ashley, Patricia L., Malcolm, William F., Auten, Kathy J., Fisher, Kimberley A., Grimes, Sandra, Gustafson, Kathryn E., Lohmeyer, Melody B., Finkle, Joanne, Laughon, Matthew M., Bose, Carl L., Bernhardt, Janice, Bose, Gennie, Clark, Cindy, Manor, Linda, Warner, Diane, Wereszczak, Janice, Carlton, David P., Stoll, Barbara J., Adams-Chapman, Ira, Hale, Ellen C., Loggins, Yvonne, Archer, Stephanie Wilson, Sokol, Gregory M., Poindexter, Brenda B., Dusick, Anna M., Papile, Lu-Ann, Gunn, Susan, Hamer, Faithe, Herron, Dianne E., Hines, Abbey C., Lytle, Carolyn, Minnich, Heike M., Smiley, Lucy, Wilson, Leslie Dawn, Sanchez, Pablo J., Nelin, Leif D., Jadcherla, Sudarshan R., Luzader, Patricia, Fortney, Christine A., Besner, Gail E., Parikh, Nehal A., Das, Abhik, Wallace, Dennis, Gantz, Marie G., Poole, W. Kenneth, Newman, Jamie E., O'Donnell Auman, Jeanette, Crawford, Margaret M., Petrie Huitema, Carolyn M., Zaterka-Baxter, Kristin M., Van Meurs, Krisa P., Stevenson, David K., Hintz, Susan R., Ball, M. Bethany, Davis, Alexis S., Palmquist, Andrew W., Proud, Melinda S., Bentley, Barbara, Bruno, Elizabeth, DeAnda, Maria Elena, DeBattista, Anne M., Earhart, Beth, Huffman, Lynne C., Kohn, Jean G., Krueger, Casey, Weiss, Hali E., Frantz, Ivan D., III, Fiascone, John M., MacKinnon, Brenda L., Furey, Anne, Nylen, Ellen, Carlo, Waldemar A., Ambalavanan, Namasivayam, Peralta-Carcelen, Myriam, Collins, Monica V., Cosby, Shirley S., Biasini, Fred J., Johnston, Kristen C., Nelson, Kathleen G., Patterson, Cryshelle S., Phillips, Vivien A., Whitley, Sally, Devaskar, Uday, Garg, Meena, Purdy, Isabell B., Chanlaw, Teresa, Geller, Rachel, Finer, Neil N., Vaucher, Yvonne E., Kaegi, David, Rasmussen, Maynard R., Arnell, Kathy, Demetrio, Clarence, Fuller, Martha G., Rich, Wade, Bell, Edward F., Colaizy, Tarah T., Acarregui, Michael J., Ellsbury, Dan L., Widness, John A., Johnson, Karen J., Campbell, Donia B., Eastman, Diane L., Walker, Jacky R., Brumbaugh, Jane E., Duara, Shahnaz, Bauer, Charles R., Everett-Thomas, Ruth, Fajardo-Hiriart, Sylvia, Rigaud, Arielle, Calejo, Maria, Frade Eguaras, Silvia M., Berkowits, Michelle Harwood, Garcia, Andrea, Pierre, Helina, Stoerger, Alexandra, Watterberg, Kristi L., Lowe, Jean R., Fuller, Janell F., Ohls, Robin K., Lacy, Conra Backstrom, Duncan, Andrea F., Montman, Rebecca, Schmidt, Barbara, Kirpalani, Haresh, DeMauro, Sara B., Chaudhary, Aasma S., Abbasi, Soraya, Mancini, Toni, Cucinotta, Dara M., Bernbaum, Judy C., Gerdes, Marsha, Hurt, Hallam, D'Angio, Carl T., Phelps, Dale L., Guillet, Ronnie, Lakshminrusimha, Satyan, Johnson, Julie Babish, Reubens, Linda J., Horihan, Cassandra A., Hust, Diane, Jensen, Rosemary L., Kushner, Emily, Merzbach, Joan, Myers, Gary J., Rowan, Mary, Wadkins, Holly I.M., Bowman, Melissa, Hunn, Julianne, Guilford, Stephanie, Maffett, Deanna, Osman, Farooq, Prinzing, Diane, Reynolds, Anne Marie, Sacilowski, Michael G., Williams, Ashley, Wynn, Karen, Yost, Kelley, Zorn, William, Zwetsch, Lauren, Kennedy, Kathleen A., Tyson, Jon E., McDavid, Georgia E., Alaniz, Nora I., Arldt-McAlister, Julie, Burson, Katrina, Evans, Patricia W., Garcia, Carmen, Green, Charles, Harris, Beverly Foley, Jiminez, Margarita, John, Janice, Jones, Patrick M., Lillie, Layne M., Lis, Anna E., Martin, Karen, Martin, Sara C., Morris, Brenda H., Poundstone, M. Layne, Robichaux, Peggy, Rodgers, Shawna, Siddiki, Saba, Simmons, Maegan C., Sperry, Daniel, Pierce Tate, Patti L., Wright, Sharon L., Wyckoff, Myra H., Brion, Luc P., Heyne, Roy J., Salhab, Walid A., Rosenfeld, Charles R., Vasil, Diana M., Chen, Lijun, Guzman, Alicia, Hensley, Gaynelle, Leps, Melissa H., Miller, Nancy A., Morgan, Janet S., Adams, Sally S., Boatman, Catherine Twell, Heyne, Elizabeth T., Madden, Linda A., Torres, Lizette E., Faix, Roger G., Yoder, Bradley A., Osborne, Karen A., Spencer, Cynthia, Weaver-Lewis, Kimberlee, Baker, Shawna, Bird, Karie, Burnett, Jill, Steffen, Michael, Jensen, Jennifer J., Winter, Sarah, Zanetti, Karen, O'Shea, T. Michael, Dillard, Robert G., Washburn, Lisa K., Jackson, Barbara G., Peters, Nancy, Chiu, Korinne, Allred, Deborah Evans, Goldstein, Donald J., Halfond, Raquel, Peterson, Carroll, Waldrep, Ellen L., Welch, Cherrie D., Morris, Melissa Whalen, Hounshell, Gail Wiley, Shankaran, Seetha, Pappas, Athina, Barks, John, Bara, Rebecca, Goldston, Laura A., Natarajan, Girija, Christensen, Mary, Wiggins, Stephanie A., White, Diane, Ehrenkranz, Richard A., Jacobs, Harris, Butler, Christine G., Cervone, Patricia, Greisman, Sheila, Konstantino, Monica, Poulsen, JoAnn, Taft, Janet, Williams, Joanne, Romano, Elaine, Laptook, Abbot. R., Lowe, Jean, Chowdhury, Dhuly, Higgins, Rosemary D., and Vohr, Betty R.
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- 2019
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373. Inter-granular cracking through strain gradient crystal plasticity and cohesive zone modeling approaches
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Yalçinkaya, T., Özdemir, İ., and Firat, A.O.
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- 2019
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374. Alginate-based bionanocomposites for cancer therapy
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Yalcinkaya, Seda, primary and Yalcin, Serap, additional
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- 2021
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375. Effect of external pressure and resin flushing on reduction of process-induced voids and enhancement of laminate quality in heated-VARTM
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Yalcinkaya, M. Akif, Sozer, E. Murat, and Altan, M. Cengiz
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- 2019
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376. Morphology and Grain Orientation Dependent Localization and Necking in Dual-phase Steels
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Çakmak, Serhat Onur and Yalçinkaya, Tuncay
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- 2019
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377. A Micromechanics Based Numerical Investigation of Dual Phase Steels
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Yalçinkaya, Tuncay, Güngör, Gönül Öykü, Çakmak, Serhat Onur, and Tekoğlu, Cihan
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- 2019
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378. Development of a Micromechanics Based Cohesive Zone Model and Application for Ductile Fracture
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Yalçinkaya, Tuncay, Tandogan, Izzet Tarik, and Cocks, Alan
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- 2019
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379. Formulation and Implementation of a New Porous Plasticity Model
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Yalçinkaya, Tuncay, Erdoğan, Can, Tandoğan, Izzet Tarik, and Cocks, Alan
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- 2019
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380. Behavioral Deficits at 18-22 Months of Age Are Associated with Early Cerebellar Injury and Cognitive and Language Performance in Children Born Extremely Preterm
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Jobe, Alan H., Caplan, Michael S., Laptook, Abbot R., Vohr, Betty R., Oh, William, Hensman, Angelita M., Alksninis, Barbara, Andrews, Dawn, Angela, Kristen, Barnett, Susan, Cashore, Bill, Caskey, Melinda, Francis, Kim, Gingras, Dan, Johnson, Katharine, Leach, Theresa M., Stephens, Bonnie E., Watson, Victoria E., Walsh, Michele C., Fanaroff, Avroy A., Newman, Nancy S., Wilson-Costello, Deanne E., Siner, Bonnie S., Zadell, Arlene, DiFiore, Julie, Bhola, Monika, Friedman, Harriet G., Yalcinkaya, Gulgun, Bulas, Dorothy, Goldberg, Ronald N., Cotten, C. Michael, Goldstein, Ricki F., Ashley, Patricia, Auten, Kathy J., Fisher, Kimberley A., Foy, Katherine A., Freedman, Sharon F., Gustafson, Kathryn E., Lohmeyer, Melody B., Malcolm, William F., Wallace, David K., Carlton, David P., Stoll, Barbara J., Adams-Chapman, Ira, Buchter, Susie, Piazza, Anthony J., Carter, Sheena, Fritz, Sobha, Hale, Ellen C., Hutchinson, Amy K., LaRossa, Maureen Mulligan, Higgins, Rosemary D., Archer, Stephanie Wilson, Sokol, Gregory M., Poindexter, Brenda B., Dusick, Anna M., Lemons, James A., Wilson, Leslie D., Hamer, Faithe, Cook, Ann B., Herron, Dianne E., Lytle, Carolyn, Minnich, Heike M., Berberich, Mary Anne, Blaisdell, Carol J., Gail, Dorothy B., Kiley, James P., Das, Abhik, Gantz, Marie G., Newman, Jamie E., Cheng, Helen, Hastings, Betty K., McClure, Elizabeth M., Auman, Jeanette O'Donnell, Huitema, Carolyn Petrie, Poole, W. Kenneth, Pickett, James W., II, Wallace, Dennis, Wrage, Lisa A., Zaterka-Baxter, Kristin M., Van Meurs, Krisa P., Stevenson, David K., Ball, M. Bethany, Barnes, Patrick D., Bentley, Barbara, Bruno, Elizabeth F., DeAnda, Maria Elena, DeBattista, Anne M., Kohn, Jean G., Proud, Melinda S., Pyle, Renee P., Weiss, Hali E., Frantz, Ivan D., III, Fiascone, John M., McGowan, Elisabeth C., Furey, Anne, MacKinnon, Brenda L., Nylen, Ellen, Brussa, Ana, Sibley, Cecelia, Carlo, Waldemar A., Ambalavanan, Namasivayam, Collins, Monica V., Cosby, Shirley S., Phillips, Vivien A., Bailey, Kirstin J., Biasini, Fred J., Hopkins, Maria, Johnston, Kristen C., Nelson, Kathleen G., Patterson, Cryshelle S., Rector, Richard V., Rodriguez, Leslie, Soong, Amanda, Whitley, Sally, York, Sheree, Finer, Neil N., Rasmussen, Maynard R., Wozniak, Paul R., Vaucher, Yvonne E., Rich, Wade, Arnell, Kathy, Barbieri-Welge, Rene, Ben-Tall, Ayala, Bridge, Renee, Demetrio, Clarence, Fuller, Martha G., Ito, Elaine, Lukasik, Meghan, Pontillo, Deborah, Posin, Donna, Runyan, Cheryl, Wilkes, James, Zlotnik, Paul, Bell, Edward F., Widness, John A., Acarregui, Michael J., Klein, Jonathan M., Colaizy, Tarah T., Johnson, Karen J., Eastman, Diane L., Duara, Shahnaz, Bauer, Charles R., Everett-Thomas, Ruth, Calejo, Maria, Diaz, Alexis N., Frade Eguaras, Silvia M., Garcia, Andrea, Hamlin-Smith, Kasey, Berkowits, Michelle Harwood, Hiriart-Fajardo, Sylvia, Mathews, Elaine O., Pierre, Helina, Riguard, Arielle, Stroerger, Alexandra, Watterberg, Kristi L., Ohls, Robin K., Fuller, Janell, Rohr, Julie, Lacy, Conra Backstrom, Lowe, Jean, Montman, Rebecca, Brown, Sandra, Laroia, Nirupama, Phelps, Dale L., Myers, Gary J., Markowitz, Gary D., Reubens, Linda J., Hust, Diane, Augostino, Lisa, Johnson, Julie Babish, Burnell, Erica, Gelbard, Harris, Jensen, Rosemary L., Kushner, Emily, Merzbach, Joan, Mink, Jonathan, Torres, Carlos, Wang, David, Yost, Kelley, Sánchez, Pablo J., Rosenfeld, Charles R., Salhab, Walid A., Heyne, Roy J., Adams, Sally S., Allen, James, Grau, Laura, Guzman, Alicia, Hensley, Gaynelle, Heyne, Elizabeth T., Hickman, Jackie F., Leps, Melissa H., Madden, Linda A., Martin, Melissa, Miller, Nancy A., Morgan, Janet S., Solis, Araceli, Torres, Lizette E., Boatman, Catherine Twell, Vasil, Diana M., Kennedy, Kathleen A., Tyson, Jon E., Evans, Patricia W., Akpa, Esther G., Alaniz, Nora I., Harris, Beverly Foley, Green, Charles, Jiminez, Margarita, Lis, Anna E., Martin, Sarah, McDavid, Georgia E., Morris, Brenda H., Poundstone, Margaret L., Reddoch, Stacy, Siddiki, Saba, Pierce Tate, Patti L., Wright, Sharon L., Yoder, Bradley A., Faix, Roger G., Baker, Shawna, Bird, Karie, Bullwinkle, Anna E., Burnett, Jill, Cole, Laura, Osborne, Karen A., Spencer, Cynthia, Steele, R. Edison, Steffen, Michael, Weaver-Lewis, Kimberlee, O'Shea, T. Michael, Dillard, Robert G., Washburn, Lisa K., Peters, Nancy J., Jackson, Barbara G., Chiu, Korinne, Allred, Deborah Evans, Goldstein, Donald J., Halfond, Raquel, Peterson, Carroll, Waldrep, Ellen L., Welch, Cherrie D., Morris, Melissa Whalen, Hounshell, Gail Wiley, Shankaran, Seetha, Sood, Beena G., Slovis, Thomas L., Pappas, Athina, Bara, Rebecca, Billian, Elizabeth, Goldston, Laura A., Johnson, Mary, Duncan, Andrea F., Bann, Carla M., Dempsey, Allison, Peralta-Carcelen, Myriam, and Hintz, Susan
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- 2019
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381. Exploring the use of Gestalt’s principles in improving the visualization, user experience and comprehension of COBie data extension
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Yalcinkaya, Mehmet and Singh, Vishal
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- 2019
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382. VisualCOBie for facilities management : A BIM integrated, visual search and information management platform for COBie extension
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Yalcinkaya, Mehmet and Singh, Vishal
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- 2019
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383. Erythroid lineage [Jak2.sup.V617F] expression promotes atherosclerosis through erythrophagocytosis and macrophage ferroptosis
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Liu, Wenli, Ostberg, Nataliya, Yalcinkaya, Mustafa, Dou, Huijuan, Endo-Umeda, Kaori, Tang, Yang, Hou, Xintong, Xiao, Tong, Fidler, Trevor P., Abramowicz, Sandra, Yang, Yong-Guang, Soehnlein, Oliver, Tall, Alan R., and Wang, Nan
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Erythrocytes -- Health aspects -- Physiological aspects ,Macrophages -- Physiological aspects -- Health aspects ,Phagocytosis -- Health aspects ,Atherosclerosis -- Development and progression -- Genetic aspects ,Health care industry - Abstract
Elevated hematocrit is associated with cardiovascular risk; however, the causality and mechanisms are unclear. The [JAK2.sup.V617F] ([JAK2.sup.VF]) mutation increases cardiovascular risk in myeloproliferative disorders and in clonal hematopoiesis. [JAK2.sup.VF] mice with elevated WBCs, platelets, and RBCs display accelerated atherosclerosis and macrophage erythrophagocytosis. To investigate whether selective erythroid [JAK2.sup.VF] expression promotes atherosclerosis, we developed hyperlipidemic erythropoietin receptor Cre mice that express [JAK2.sup.VF] in the erythroid lineage (VFEpoR mice). VFEpoR mice without elevated blood cell counts showed increased atherosclerotic plaque necrosis, erythrophagocytosis, and ferroptosis. Selective induction of erythrocytosis with low-dose erythropoietin further exacerbated atherosclerosis with prominent ferroptosis, lipid peroxidation, and endothelial damage. VFEpoR RBCs had reduced antioxidant defenses and increased lipid hydroperoxides. Phagocytosis of human or murine WT or [JAK2.sup.VF] RBCs by WT macrophages induced ferroptosis, which was prevented by the ferroptosis inhibitor liproxstatin-1. Liproxstatin-1 reversed increased atherosclerosis, lipid peroxidation, ferroptosis, and endothelial damage in VFEpoR mice and in [JAK2.sup.VF] chimeric mice simulating clonal hematopoiesis, but had no impact in controls. Erythroid lineage [JAK2.sup.VF] expression led to qualitative and quantitative defects in RBCs that exacerbated atherosclerosis. Phagocytosis of RBCs by plaque macrophages promoted ferroptosis, suggesting a therapeutic target for reducing RBC-mediated cardiovascular risk., Introduction Elevated hematocrit is associated with increased atherothrombotic cardiovascular disease (ACD), the number one cause of death and disability in Western societies (1, 2). Observational studies have shown that human [...]
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- 2022
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384. Construction of Curtis-Phan-Tits system in black box classical groups
- Author
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Borovik, Alexandre and Yalcinkaya, Sukru
- Subjects
Mathematics - Group Theory - Abstract
We present a polynomial time Monte-Carlo algorithm for finite simple black box classical groups of odd characteristic which constructs all root ${\rm{SL}}_2(q)$-subgroups associated with the nodes of the extended Dynkin diagram of the corresponding algebraic group., Comment: 35 pages
- Published
- 2010
385. Construction of long root SL(2,q)-subgroups in black box groups
- Author
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Yalcinkaya, Sukru
- Subjects
Mathematics - Group Theory - Abstract
We present a one sided Monte--Carlo algorithm which constructs a long root $\sl_2(q)$-subgroup in $X/O_p(X)$, where $X$ is a black-box group and $X/O_p(X)$ is a finite simple group of Lie type defined over a field of odd order $q=p^k > 3$ for some $k\geqslant 1$. Our algorithm is based on the analysis of the structure of centralizers of involutions and can be viewed as a computational version of Aschbacher's Classical Involution Theorem. We also present an algorithm which determines whether the $p$-core (or "unipotent radical") $O_p(X)$ of a black-box group $X$ is trivial or not, where $X/O_p(X)$ is a finite simple classical group of odd characteristic $p$. This answers a well-known question of Babai and Shalev., Comment: 37 pages, submitted to Journal of Algebra
- Published
- 2010
386. CLP1 Founder Mutation Links tRNA Splicing and Maturation to Cerebellar Development and Neurodegeneration
- Author
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Schaffer, Ashleigh E, Eggens, Veerle RC, Caglayan, Ahmet Okay, Reuter, Miriam S, Scott, Eric, Coufal, Nicole G, Silhavy, Jennifer L, Xue, Yuanchao, Kayserili, Hulya, Yasuno, Katsuhito, Rosti, Rasim Ozgur, Abdellateef, Mostafa, Caglar, Caner, Kasher, Paul R, Cazemier, J Leonie, Weterman, Marian A, Cantagrel, Vincent, Cai, Na, Zweier, Christiane, Altunoglu, Umut, Satkin, N Bilge, Aktar, Fesih, Tuysuz, Beyhan, Yalcinkaya, Cengiz, Caksen, Huseyin, Bilguvar, Kaya, Fu, Xiang-Dong, Trotta, Christopher R, Gabriel, Stacey, Reis, André, Gunel, Murat, Baas, Frank, and Gleeson, Joseph G
- Subjects
Biochemistry and Cell Biology ,Biomedical and Clinical Sciences ,Biological Sciences ,Neurodegenerative ,Genetics ,Neurosciences ,Aetiology ,2.1 Biological and endogenous factors ,Generic health relevance ,Neurological ,Animals ,Brain ,Cerebellum ,Cleavage And Polyadenylation Specificity Factor ,Female ,Humans ,Male ,Mice ,Models ,Molecular ,Neurodegenerative Diseases ,Nuclear Proteins ,Pedigree ,Phosphotransferases ,RNA Splicing ,RNA ,Transfer ,Saccharomyces cerevisiae ,Transcription Factors ,Zebrafish ,Zebrafish Proteins ,Medical and Health Sciences ,Developmental Biology ,Biological sciences ,Biomedical and clinical sciences - Abstract
Neurodegenerative diseases can occur so early as to affect neurodevelopment. From a cohort of more than 2,000 consanguineous families with childhood neurological disease, we identified a founder mutation in four independent pedigrees in cleavage and polyadenylation factor I subunit 1 (CLP1). CLP1 is a multifunctional kinase implicated in tRNA, mRNA, and siRNA maturation. Kinase activity of the CLP1 mutant protein was defective, and the tRNA endonuclease complex (TSEN) was destabilized, resulting in impaired pre-tRNA cleavage. Germline clp1 null zebrafish showed cerebellar neurodegeneration that was rescued by wild-type, but not mutant, human CLP1 expression. Patient-derived induced neurons displayed both depletion of mature tRNAs and accumulation of unspliced pre-tRNAs. Transfection of partially processed tRNA fragments into patient cells exacerbated an oxidative stress-induced reduction in cell survival. Our data link tRNA maturation to neuronal development and neurodegeneration through defective CLP1 function in humans.
- Published
- 2014
387. Optimization of Electrospun TORLON ® 4000 Polyamide-Imide (PAI) Nanofibers: Bridging the Gap to Industrial-Scale Production.
- Author
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Yalcinkaya, Baturalp and Buzgo, Matej
- Subjects
- *
THERMAL resistance , *POLYAMIDES , *GAS industry , *HIGH temperatures , *PETROLEUM industry , *NANOFIBERS - Abstract
Polyamide-imide (PAI) is an exceptional polymer known for its outstanding mechanical, chemical, and thermal resistance. This makes it an ideal choice for applications that require excellent durability, such as those in the aerospace sector, bearings, gears, and the oil and gas industry. The current study explores the optimization of TORLON® 4000 T HV polyamide-imide nanofibers utilizing needleless electrospinning devices, ranging from laboratory-scale to industrial-scale production, for the first time. The PAI polymer has been dispersed in several solvent systems at varying concentrations. The diameter of the electrospun PAI nanofibers ranged from 65.8 nanometers to 1.52 μm. Their filtering efficiency was above 90% for particles with a size of 0.3 microns. The TGA results proved that PAI nanofibers have excellent resistance to high temperatures up to 450 °C. The PAI nanofibers are ideal for hot air intake filtration and fire-fighter personal protection equipment applications. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
388. The effects of subchorionic hematomas on the future of pregnancies with threatened miscarriage.
- Author
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Seyhanli, Zeynep, Karabay, Gulsan, Bucak, Mevlut, Aktemur, Gizem, Yalcinkaya, Merve, Sucu, Serap Topkara, Cendek, Busra Demir, and Caglar, Ali Turhan
- Subjects
HEMATOMA ,MISCARRIAGE ,PREGNANT women ,PREGNANCY complications ,DEMOGRAPHIC surveys - Abstract
Aim: The clinical significance of first trimester subchorionic hematoma, which is worrisome to pregnant women in terms of the outcome of the pregnancy, still remains unclear. The objective of this study is to examine the association between subchorionic hematomas in patients with threatened miscarriage and adverse pregnancy outcomes. Materials and Methods: The retrospective cohort study was conducted in a tertiary center from September 2022 to January 2024. 200 patients who were hospitalized with threatened miscarriage during the sixth to fourteenth week of a singleton pregnancy were included. The individuals that satisfy the established criteria for the study were categorized into two groups with threatened miscarriage based on the ultrasound examination: the study group, which included patients with subchorionic hematoma and the control group, which included patients without subchorionic hematoma. Demographic information, maternal and neonatal outcomes were compared for both groups. Results: Maternal age, BMI, parity, gestational age at diagnosis, history of abortus were similar for both groups (p>0.05). Miscarriage rates were higher in the group with SCH than without SCH (28% vs. 25%, p= 0.631), but no statistical significance was observed. The frequencies of intrauterine death, gestational age at delivery, preterm delivery, mode of delivery, hypertensive disorders of pregnancy, placenta previa-placenta accreta spectrum, gestational diabetes mellitus, intrauterine growth restriction were not statistically significant (p>0.05) between groups. The hematoma sizes did not show any statistically significant difference between those whose pregnancies led to miscarriage and those whose pregnancies did not (29.6±14.30 mm vs. 27.1±14.58 mm, respectively; p = 0.367). The subchorionic hematoma diameters did not show any correlation with the gestational age at delivery, birth weight, APGAR scores at 1st and 5th minute. Conclusion: Our study suggests that detection of threatened miscarriage with subchorionic hematoma did not result in an elevation in miscarriage rates, maternal and neonatal complications. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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389. Effectiveness of carotid council in the treatment of carotid artery disease: Early-term outcomes of the multidisciplinary approach.
- Author
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Ozbek, Ismail C, Durmaz, Aysegul, Ozen, Yucel, Demir, Serkan, Celik, Didem, Yalcinkaya, Emre, Cunurlu, Merve, and Ugur, Murat
- Abstract
Objectives: Carotid arterial stenosis could be treated by surgical or percutaneous stenting. In this study, we aimed to investigate the effectiveness of the carotid council on the outcomes of patients with carotid artery disease. Methods: In this retrospective study, we analyzed the patients who had undergone carotid arterial revascularization from April 2014 to July 2022 in our hospital. All patients were evaluated in carotid council, which is constituted by neurologist, cardiologist and cardiovascular surgeon. Patient-specific treatment procedure was decided in the council. Demographics and early-term follow-up results of the patients were evaluated. Results: Totally 95 procedures in 85 patients were analyzed during the study period. 27.4 % of the patients had significant contralateral carotid arterial stenosis. In 88 (92.6%) procedures, patients were treated by carotid endarterectomy, and 5 procedures were performed under regional anesthesia. Shunt usage was 6.0% during the surgery, and arteriotomy was repaired with primary sutures in 87.3%. Stent implantation was performed in 7 patients. There were 5 neurological adverse events after the carotid endarterectomy and 2 neurological events were after carotid arterial stenting. In each treatment group, one patient died after the procedure. In the follow-up period, restenosis was observed just in a patient who was treated with carotid endarterectomy and primary repair. Conclusion: Although carotid artery disease could be treated in accordance with the guidelines, treatment procedures should be patient-specific. Carotid councils might be helpful in giving patient-specific decisions, thereby providing the patient-based treatment procedure and improving the outcomes of the patients with carotid artery disease. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
390. An ultrahigh frequency dielectric sensor for microdroplet detection using a split ring resonator-based microfluidic chip.
- Author
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Teymoori, Morteza and Yalcinkaya, Arda Deniz
- Subjects
- *
MICROFLUIDIC devices , *CHEMICAL detectors , *DIELECTRICS , *MATERIALS testing , *MICROSTRIP transmission lines , *PERMITTIVITY , *METAMATERIALS - Abstract
Metamaterials have drawn interest in the sensor community due to their extreme dielectric-sensitive resonant behavior. Although these structures are studied in a wide range of frequencies, the ultrahigh frequencies are of special interest due to their compatibility with RF electronics. Unlike spectroscopic methods, where each material has its specific fingerprint, the response of these resonant structures depends on the electromagnetic properties, the volume of the material under test, and the resonator's design itself. Thus, implementing a metamaterial-based sensor for biological and chemical applications requires some mechanism to fix the sample's location and volume. Since most biological and chemical samples are liquids, microfluidics is the most promising candidate for this task. Here, we propose a dielectric sensing platform with a cost-effective fabrication method that allows fluid detection inside the microfluidic channel. The device proposed here is designed numerically, fabricated and measured, and finally validated via an analytical lumped model. It consists of a microstrip line coupled with a split ring resonator as the transducer and a microfluidic structure to control the sample and generate microdroplets. The fluid under test inside the microfluidic channel can be characterized based on the change in its dielectric constant or loss factor. The device shows a 600 kHz resonance shift in response to the dielectric change in sample volumes as low as 10 nl. We also demonstrate the platform's capability to generate and detect octanol–water microdroplets. The method reported here offers a fast prototyping method suitable for various microfluidic sensing applications. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
391. Surface-modified PVDF membranes for separation of dye by forward osmosis.
- Author
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Muratow, Marta, Yalcinkaya, Fatma, Bryjak, Marek, and Siekierka, Anna
- Subjects
MEMBRANE separation ,OSMOSIS ,AROMATIC amines ,DYES & dyeing ,POLYAMIDES - Abstract
Modification of membranes is widely used for altering their separation properties. In this study, the modification of PVDF nanofiber mat by deposition of polyamide layers was evaluated to improve dye recovery by means of forward osmosis process. The polyamide active layer was prepared by a reaction of cyclic aromatic amines, m-phenylenediamine, or piperazine, and trimesoylchloride. The modification progress was monitored by FTIR analysis, water uptake, nitrogen content, and grafting yields. Investigated membranes showed an excellent dye separation features with water flux and dye fluxes strongly related to type of applied amines and reaction time. The best obtained membrane demonstrated outstanding performance in forward osmosis; their water flux was 3.3 LMH and rejection rate of 97% for bromocresol green dye. The membrane allowed increase dye concentration by 50% after 24 h of the process. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
392. Hierarchical Classification of Analog and Digital Modulation Schemes Using Higher-Order Statistics and Support Vector Machines.
- Author
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Yalcinkaya, Bengisu, Coruk, Remziye Busra, Kara, Ali, and Tora, Hakan
- Subjects
DIGITAL modulation ,SUPPORT vector machines ,CLASSIFICATION algorithms ,AUTOMATIC classification ,CLASSIFICATION ,BACK propagation - Abstract
Automatic modulation classification (AMC) algorithms are crucial for various military and commercial applications. There have been numerous AMC algorithms reported in the literature, most of which focus on synthetic signals with a limited number of modulation types having distinctive constellations. The efficient classification of high-order modulation schemes under real propagation effects using models with low complexity still remains difficult. In this paper, employing quadratic SVM, a feature-based hierarchical classification method is proposed to accurately classify especially higher-order modulation schemes and its performance is investigated using over the air (OTA) collected data. Statistical features, higher-order moments, and higher-order cumulants are utilized as features. Then, the performances of some well-known classifiers are evaluated, and the classifier presenting the best performance is employed in the proposed hierarchical classification model. An OTA dataset containing 17 analog and digital modulation schemes is used to assess the performance of the proposed classification model. With the proposed hierarchical classification algorithm, a significant improvement has been achieved, especially in higher-order modulation schemes. The overall accuracy with the proposed hierarchical structure is 96% after 5 dB signal-to-noise ratio value, approximately a 10% increase is achieved compared to the traditional classification algorithm. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
393. The impact of gender diversity on junior versus senior biomedical scientists' NIH research awards.
- Author
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Liu, Christopher C., Yalcinkaya, Beril, Back, Andy S., and Ding, Waverly W.
- Abstract
Unearthing within-group inequality in science funding and careers highlights a new mechanism explaining the disadvantages faced by younger generations of women scientists. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
394. A Novel Homozygous ACBD5 Variant in an Emerging Peroxisomal Disorder Presenting with Retinal Dystrophy and a Review of the Literature.
- Author
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Hasturk, Berfin Ayla, Cinar, Çisem, Zubarioglu, Tanyel, Tiryaki-Demir, Semra, Cansever, Mehmet Serif, Kiykim, Ertugrul, Kalaycı Yigin, Aysel, Yalcinkaya, Cengiz, and Aktuglu-Zeybek, Cigdem
- Published
- 2024
- Full Text
- View/download PDF
395. Multi-functional Core/Sheath Bicomponent Nonwoven of Recycled Poly(ethylene terephthalate) Fibres as Thermal Insulators.
- Author
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Hunskunatai, Danu, Pivsa-Art, Weraporn, Roungpaisan, Nanjaporn, Boonyod, Saowaluk, Yalcinkaya, Fatma, and Pivsa-Art, Sommai
- Subjects
SINGLE-use plastics ,FIREPROOFING agents ,EXTRUSION process ,ETHYLENE ,WASTE recycling - Abstract
The consumption of poly(ethylene terephthalate) (PET) has experienced a surge in recent times, owing to the widespread use of single-use plastic bottles, particularly in the context of beverages and drinking water. PET, a thermoplastic polymer, is known for its recyclability, and the recycled variant is referred to as rPET. The incorporation of rPET in fiber manufacturing is favored due to its cost-effectiveness, and the functionalized rPET fibers present an innovative product that can be used in a variety of applications. This study aimed to functionalize rPET fibers using the spun-bond technique, imparting antibacterial and flame-retardant properties, which are commonly employed in thermal insulator products. Nano zinc oxide (nano-ZnO) was used to confer antibacterial functionality, while phosphorus flame retardant (PFR) was used to impart flame-retardant properties. The core-sheath bicomponent fiber structure was employed to achieve the desired outcomes. The extrusion process was used to incorporate PFR and ZnO as the core and sheath components, respectively, at various ratios. The presence of nano-ZnO on the fiber shell was confirmed by the EDX data. The flame retardant study was utilized to observe the level of burning damage. The findings of the study demonstrated that increasing the percentage of PFR (maximum 8%) resulted in a significant decrease in the damage distance of the nonwoven material, with reductions of up to 60% was observed. Furthermore, the results of the antibacterial test indicated that the inclusion of an additional 3 wt% of ZnO resulted in a considerable reduction of the bacteria S. aureus and K. pneumoniae by about 99.96 and 98.79%, respectively. Based on the results obtained, it was determined that the most effective functionalized fiber was synthesized by including 3 wt% of ZnO and 5 wt% of PFR. Moreover, the incorporation of varying proportions of additives resulted in modifications to the mechanical and thermal characteristics of the fibers. This work highlights the potential of functionalized rPET bicomponent fibers as viable candidates for thermal insulator products. The utilization of functionalized rPET bicomponent fibers as a sustainable alternative for thermal insulator products showcases the commitment to environmentally friendly solutions, contributing to the overall goal of sustainability in the manufacturing industry. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
396. Plasma sphingolipids in patients with sickle cell disease: Multiple‐site vaso‐occlusive crises could be associated with lower sphingolipid levels.
- Author
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Alp, Gokce, Oztas, Yesim, Yalcinkaya, Ahmet, Ozel, Selinay, Yildirim, Nazim, and Unal, Selma
- Abstract
Although sickle cell disease (SCD) and its manifestations have been associated with various lipid alterations, there are a few studies exploring the impact of sphingolipids in SCD. In this study, we determined plasma ceramide (Cer) and sphingomyelin (CerPCho) species and investigated their association with the crisis in SCD. SCD patients (N = 27) suffering from vaso‐occlusive crisis (VOC) or acute chest syndrome (ACS) were involved in this study. Blood samples were drawn at crisis and later at steady state periods. Clinical history, white blood cell count (WBC), C‐reactive protein and lactate dehydrogenase (LDH) levels were recorded. 16:0, 18:0, 20:0, 22:0 Cer and 16:0, 18:0, 24:0 CerPCho were measured via LC–MS/MS. All measured Cer and CerPCho levels of SCD patients at crisis and steady‐state were found to be similar. Inflammation‐related parameters were significantly higher in patients with ACS compared to single‐site VOC. Patients with multiple‐site VOC were found to have significantly lower sphingolipid levels compared with those with single‐site VOC, at crisis (16, 18, 24 CerPCho and 18, 22 Cer) and at steady‐state (24:0 CerPCho and 18 Cer). Our results show that sphingolipid levels in SCD patients are similar during crisis and at steady state. However, lower sphingolipid levels appear to be associated with the development of multiple‐site VOC. Since the differences were observed at both crisis and steady‐state, sphingolipid level could be an underlying factor associated with crisis characteristics in patients with SCD. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
397. Relation Between Serum Uric Acid to Albumin Ratio and Severity of Chronic Coronary Artery Disease.
- Author
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Yalcinkaya, Damla, Karacali, Kadir, Ilhan, Bilal Canberk, and Yarlioglues, Mikail
- Subjects
- *
ALBUMINS , *STATISTICS , *CONFIDENCE intervals , *MULTIVARIATE analysis , *RETROSPECTIVE studies , *ANGINA pectoris , *FISHER exact test , *MANN Whitney U Test , *REGRESSION analysis , *SEVERITY of illness index , *CORONARY angiography , *CORONARY artery disease , *DESCRIPTIVE statistics , *URIC acid , *BLOOD testing , *DATA analysis , *DATA analysis software , *SENSITIVITY & specificity (Statistics) , *STATISTICAL correlation , *ODDS ratio - Abstract
Uric acid (UA) to albumin ratio (UAR) is an emerging marker to predict coronary artery disease (CAD)-related events. There is limited data on the relationship between UAR and the severity of the disease in chronic CAD patients. We aimed to evaluate UAR as an indicator for CAD severity using the Syntax score (SS). We retrospectively enrolled 558 patients with stable angina pectoris and underwent coronary angiography (CAG). Patients were divided into 2 groups, according to CAD severity: low SS (≤22) and intermediate-high SS (>22) groups. UA levels were higher and albumin levels were lower in the intermediate-high SS score group (P <.001). UAR levels were significantly higher in the intermediate-high SS group (P <.001). Also, there was a significant correlation between UAR levels and SS (r =.55, 95% confidence interval (CI):.49–.60, P <.001). In multivariable analysis, UAR >1.34 (Odds ratio, 3.8 [2.3–6.2]; P <.001) was an independent predictor of intermediate-high SS while albumin and UA levels were not. In conclusion, UAR predicted disease burden in chronic CAD patients. It may prove useful as a simple and readily available marker to select patients for further evaluation. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
398. Sphingosine-1-phosphate receptor 3 regulates the transendothelial transport of high-density lipoproteins and low-density lipoproteins in opposite ways.
- Author
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Velagapudi, Srividya, Wang, Dongdong, Poti, Francesco, Feuerborn, Renata, Robert, Jerome, Schlumpf, Eveline, Yalcinkaya, Mustafa, Panteloglou, Grigorios, Potapenko, Anton, Simoni, Manuela, Rohrer, Lucia, Nofer, Jerzy-Roch, and Eckardstein, Arnold von
- Subjects
LOW density lipoproteins ,HIGH density lipoproteins ,SPHINGOSINE-1-phosphate ,BLOOD lipoproteins ,LIPOPROTEINS ,LIPOPROTEIN A - Abstract
Aims The entry of lipoproteins from blood into the arterial wall is a rate-limiting step in atherosclerosis. It is controversial whether this happens by filtration or regulated transendothelial transport. Because sphingosine-1-phosphate (S1P) preserves the endothelial barrier, we investigated in vivo and in vitro , whether S1P and its cognate S1P-receptor 3 (S1P
3 ) regulate the transendothelial transport of lipoproteins. Methods and results Compared to apoE-haploinsufficient mice (CTRL), apoE-haploinsufficient mice with additional endothelium-specific knock-in of S1P3 (S1P3 -iECKI) showed decreased transport of LDL and Evan's Blue but increased transport of HDL from blood into the peritoneal cave. After 30 weeks of high-fat diet feeding, S1P3 -iECKI mice had lower levels of non-HDL-cholesterol and less atherosclerosis than CTRL mice. In vitro stimulation with an S1P3 agonist increased the transport of125 I-HDL but decreased the transport of125 I-LDL through human aortic endothelial cells (HAECs). Conversely, inhibition or knock-down of S1P3 decreased the transport of125 I-HDL but increased the transport of125 I-LDL. Silencing of SCARB1 encoding scavenger receptor B1 (SR-BI) abrogated the stimulation of125 I-HDL transport by the S1P3 agonist. The transendothelial transport of125 I-LDL was decreased by silencing of SCARB1 or ACVLR1 encoding activin-like kinase 1 but not by interference with LDLR. None of the three knock-downs prevented the stimulatory effect of S1P3 inhibition on transendothelial125 I-LDL transport. Conclusion S1P3 regulates the transendothelial transport of HDL and LDL oppositely by SR-BI-dependent and SR-BI-independent mechanisms, respectively. This divergence supports a contention that lipoproteins pass the endothelial barrier by specifically regulated mechanisms rather than passive filtration. [ABSTRACT FROM AUTHOR]- Published
- 2024
- Full Text
- View/download PDF
399. Changes in Corneal Dynamics and Effective Optical Zone After Transepithelial Photorefractive Keratectomy for Myopia.
- Author
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Cakir, Gulay Yalcinkaya, Cakir, Ihsan, Yildiz, Burcin Kepez, and Yildirim, Yusuf
- Subjects
PHOTOREFRACTIVE keratectomy ,MYOPIA treatment ,POSTOPERATIVE period ,CONFIDENCE intervals ,PARAMETER estimation - Abstract
Objectives: The objective of this study was to analyze the changes in the effective optical zones (EOZ) using topographic techniques on the tangential curvature difference map at post-operative 1-year following transepithelial photorefractive keratectomy (T-PRK) and to identify parameters linked to the EOZ alterations. Methods: The study comprised 55 eyes of 55 myopic patients who underwent T-PRK. EOZs were measured using the tangential curvature difference map of the Scheimpflug tomography system. Correlations between the EOZ alterations and relevant parameters were assessed. Results: The EOZ was significantly lower than the programmed optical zone (p<0.001). The decrease in the EOZ was significantly relevant to the decrease in mean keratometry (p=0.01, B/95% confidence interval [CI]: 0.139/0.033 and 0.244, standardized Beta: 0.346) and the increase in maximum keratometry (p=0.003, B/95% CI: 0.072/0.026 and 0.118, standardized Beta: 0.406). Conclusion: The EOZ decreased in the 1
st year after T-PRK in eyes with myopia. The decrease in the EOZ was correlated positively with the decrease in mean and maximum keratometry. T-PRK may be an effective and safe surgery for the correction of mild-to-moderate myopia. [ABSTRACT FROM AUTHOR]- Published
- 2024
- Full Text
- View/download PDF
400. Relationship Between Platelet Parameters and Eosinophils with Disease Severity, CRP and Treatment in Stable COPD.
- Author
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Yalcinkaya Kara, Zeynep Mine, Yagci, Sema, Ozkarafakili, Mufide Arzu, and Bardakci, Mustafa Ilteris
- Subjects
BLOOD platelets ,EOSINOPHILS ,OBSTRUCTIVE lung diseases ,HEMOSTASIS ,MEDICAL care ,MEDICAL personnel - Abstract
Objectives: Chronic obstructive pulmonary disease (COPD) is a complex inflammatory condition that primarily impairs respiration but can also affect hemostasis. This study aimed to determine differences in platelet-related parameters and eosinophil between COPD patients and healthy controls. Methods: We included 149 patients with stable COPD and 30 healthy controls who were recruited from the outpatient department of Chest Diseases. Complete blood count, including platelet count (Plt), and C-reactive protein were measured. Other platelet- related parameters were determined, including mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (Pct), their ratios (MPV/Plt, MPV/Pct, PDW/Plt, PDW/Pct), and platelet to lymphocyte ratio (PLR). Results: COPD patients and controls did not show significant differences in platelet parameters (Plt, Pct, PDW, MPV, PDW/Pct, MPV/ Pct). PLR was significantly higher in the patient groups than in the control group (p=0.009). Correlation between platelet count and PLR (p=0.047; p=0.05) showed borderline significance. However, we found no correlation between the patients' CRP levels, Pct, PDW, PDW/Pct, MPV/Pct and MPV values. There were no significant differences in platelet parameters in patients using and not using long-acting muscarinic antagonists (LAMA). We did not find differences in eosinophil levels among COPD severity grades. Conclusion: In our study, we found that PLR is elevated in COPD. PLR could be a useful and easily accessible parameter to evaluate ongoing inflammation in stable COPD. Large-scale studies are warranted to further investigate the role of platelet and eosinophil parameters in COPD. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
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