185 results on '"Wang, Sufen"'
Search Results
152. A Framework Model Study for Ontology-Driven ETL Processes
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Zhang, Zhuolun, primary and Wang, Sufen, additional
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- 2008
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153. AN APPROACH TO ANALYZING THE BIDIRECTIONAL VALUES
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PAN, CHENYIN, primary and WANG, SUFEN, additional
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- 2008
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154. A HERMENEUTIC APPROACH TO ‘INFORMATION ANALYSIS’ FOR INFORMATION REQUIREMENTS
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WANG, SUFEN, primary and FENG, JUNNKANG, additional
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- 2008
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155. Distribution of chlorophyll and harmful algal blooms (HABs): A review on space based studies in the coastal environments of Chinese marginal seas
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Wei, GuiFeng, primary, Tang, DanLing, additional, and Wang, Sufen, additional
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- 2008
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156. Modelling hydrological response to different land‐use and climate change scenarios in the Zamu River basin of northwest China
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Wang, Sufen, primary, Kang, Shaozhong, additional, Zhang, Lu, additional, and Li, Fusheng, additional
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- 2007
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157. Zoniporide preserves left ventricular compliance during ventricular fibrillation and minimizes postresuscitation myocardial dysfunction through benefits on energy metabolism*
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Ayoub, Iyad M., primary, Kolarova, Julieta D., additional, Kantola, Ronald L., additional, Radhakrishnan, Jeejabai, additional, Wang, Sufen, additional, and Gazmuri, Raúl J., additional
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- 2007
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158. Occurrences of harmful algal blooms (HABs) associated with ocean environments in the South China Sea
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Wang, SuFen, primary, Tang, DanLing, additional, He, FangLiang, additional, Fukuyo, Yasuwo, additional, and Azanza, Rhodora V., additional
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- 2007
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159. Myocardial Protection by Erythropoietin During Resuscitation from Ventricular Fibrillation
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Singh, Dinesh, primary, Kolarova, Julieta D, additional, Wang, Sufen, additional, Ayoub, Iyad M, additional, and Gazmuri, Raúl J, additional
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- 2007
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160. Limiting sarcolemmal Na+entry during resuscitation from ventricular fibrillation prevents excess mitochondrial Ca2+accumulation and attenuates myocardial injury
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Wang, Sufen, primary, Radhakrishnan, Jeejabai, additional, Ayoub, Iyad M., additional, Kolarova, Julieta D., additional, Taglieri, Domenico M., additional, and Gazmuri, Raúl J., additional
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- 2007
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161. Circulating levels of cytochromecafter resuscitation from cardiac arrest: a marker of mitochondrial injury and predictor of survival
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Radhakrishnan, Jeejabai, primary, Wang, Sufen, additional, Ayoub, Iyad M., additional, Kolarova, Julieta D., additional, Levine, Rita F., additional, and Gazmuri, Raúl J., additional
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- 2007
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162. A TiO2-Sol-Gel Derived Prussian Blue Nanoparticles-Based Glucose Biosensor
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Li, Jianping, primary, Wang, Sufen, additional, Ayoub, Jyad M, additional, and Yang, Catherine F., additional
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- 2007
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163. Research on Roller Circumferential Contour Model of Deformation Zone for Warm Rolling Strip.
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Li Zhijie, Wang Sufen, and Zhou Zhaozhong
- Subjects
- *
DEFORMATIONS (Mechanics) , *ANSYS (Computer system) , *FINITE element method - Abstract
Study the circumferential contour of the deformation zone in the strip warm rolling, according the flow stress characteristic of warm deformation, the contact arc of deformation area is divided into three different curvature arc, the roller elastic flattening model of deformation zone is established using the method of quadratic curve fitting. The roller circumferential contour was calculated that iterative solver the roller elastic flattening deformation area and the distribution of rolling force along the rolling direction. Deformation process of warm-rolling was simulated using ANSYS/LS-DYNA finite element, the trend with simulation and calculated in the forward and backward slip zone is accordance, the model is more consistent with deformation process of the strip warm rolling. [ABSTRACT FROM AUTHOR]
- Published
- 2015
164. Abstract 606: Myocardial Protection by Glycogen Synthase Kinase-3β Inhibition during Resuscitation from Cardiac Arrest
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Radhakrishnan, Jeejabai, primary, Ayoub, Iyad M, additional, Wang, Sufen, additional, Kolarova, Julieta D, additional, Taglieri, Domenico M, additional, and Gazmuri, Raúl J, additional
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- 2006
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165. CYTOCHROME C: A NOVEL BIOMARKER FOR PREDICTING SURVIVAL AFTER CARDIAC RESUSCITATION.
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Ayoub, Iyad M, primary, Wang, Sufen, additional, Radhakrishnan, Jeejabai, additional, Kolarova, Julieta D, additional, Lyu, Theodore, additional, Carr, Ryan, additional, and Gazmuri, Raul J, additional
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- 2005
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166. CARDIOPROTECTION BY ERYTHROPOIETIN DURING RESUSCITATION FROM VENTRICULAR FIBRILLATION.
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Ayoub, Iyad M, primary, Kolarova, Julieta D, additional, Wang, Sufen, additional, Gazmuri, Raul J, additional, Singh, Dinesh, additional, and Havalad, Suresh H, additional
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- 2005
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167. ZONIPORIDE AMELIORATES POST-RESUSCITATION MYOCARDIAL DYSFUNCTION BY FLOW INDEPENDENT MECHANISMS
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Ayoub, Iyad M, primary, Kolarova, Julieta D, additional, Radhakrishnan, Jeejabai, additional, Wang, Sufen, additional, and Gazmuri, Raul J, additional
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- 2004
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168. ZONIPORIDE AMELIORATES INTRAMYOCARDIAL LACTATE INCREASES DURING RESUSCITATION FROM VENTRICULAR FIBRILLATION
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Radhakrishnan, Jeejabai, primary, Wang, Sufen, additional, Ayoub, Iyad M, additional, Kolarova, Julieta D, additional, and Gazmuri, Raul J, additional
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- 2004
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169. Adsorptive Complex Wave of Cadmium-phenylthiourea and Its Application
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Li, Qilong, primary, Li, Lin, additional, Wang, Sufen, additional, and Zhang, Ping, additional
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- 1991
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170. A Multi-Objective Hierarchical Model for Irrigation Scheduling in the Complex Canal System.
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Guo, Shanshan, Zhang, Fan, Zhang, Chenglong, An, Chunjiang, Wang, Sufen, and Guo, Ping
- Abstract
Due to population growth, environmental pollution and climate change, the lack of water resources has become a critical factor which threatens sustainable agricultural development. Reasonable irrigation scheduling strategies can reduce the waste of water and enhance agricultural water-use efficiency. In the present study, the decomposition-coordination theory was adopted to analyze the hierarchical canal system. A novel nonlinear multi-level multi-objective optimization model for complex canal systems was established, taking account of the multiple demands from decision makers and realistic factors of canal operation. An interactive method of the technique for order preference using similarity algorithm and genetic algorithm was proposed to solve the developed model. The developed model was successfully applied for the operational strategy making of a canal system located in the arid area of northwest China. The results indicated that the optimization model could help shorten the operational duration by two days, achieve about 26% reduction of irrigation water consumption, and improve the efficiency of water delivery from 0.566 to 0.687. That will be very favorable for the promotion of the agricultural water productivity, the relief of water shortage crisis and the sustainable development of agriculture. The outcomes can provide a wide range of support for decision making and make irrigation decision-making more scientific and systematic. [ABSTRACT FROM AUTHOR]
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- 2019
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171. Polycystin-1 loss of function increases susceptibility to atrial fibrillation through impaired DNA damage response.
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Hendrickson T, Abigail Giese A, Fiedler M, Perez W, Reyes-Sanchez E, Reyes-Lozano M, Wang S, Venegas-Zamora L, Provasek V, El-Essawi A, Breitenbach I, Fakuade FE, Kutschka I, Schiattarella GG, Voigt N, Valderrabano M, and Altamirano F
- Abstract
Background: The increasing prevalence of atrial fibrillation (AF) and chronic kidney diseases highlights the need for a deeper comprehension of the molecular mechanisms linking them. Mutations in PKD1, the gene encoding Polycystin-1 (PKD1 or PC1), account for 85% of autosomal dominant polycystic kidney disease (ADPKD) cases. This disease often includes cardiac complications such as AF. In cardiomyocytes, PC1 deletion reduces hypertrophic response to pressure overload but promotes baseline ventricular dysfunction, while deletion in fibroblasts ameliorates post-myocardial infarction fibrosis. Despite its known cardiac impact, the role of PC1 in atrial cardiomyocytes and arrhythmias is less understood. Here, we sought to investigate the role of PC1 in AF., Methods: We used intracardiac programmed stimulation and optical mapping to evaluate AF inducibility in two mouse models, Pkd1 R3277C, which recapitulates human ADPKD progression, and cardiomyocyte-specific Pkd1 deletion, and their respective controls. Isolated adult mouse atrial cardiomyocytes, human iPSC-derived atrial cardiomyocytes (hiPSC-aCM), and HL-1 cells served as in vitro cellular models. Molecular mechanisms were evaluated using optical mapping and molecular and biochemical approaches., Results: Loss-of-function PC1 mutations significantly increased AF susceptibility in vivo and facilitated local reentry in ex vivo left atrial appendages. Comprehensive in vitro experiments supported a direct effect of PC1 in atrial cardiomyocytes. PC1-deficient monolayers exhibited increased arrhythmic events, escalating into reentrant spiral waves post-tachypacing. Transcriptomics analysis revealed PC1-dependent regulation of DNA repair, with PC1 deficiency leading to increased DNA damage under stress. PARP1 inhibitors or nicotinamide riboside, which counteract DNA damage-related metabolic consequences, reduced in vitro arrhythmias PC1-deficient monolayers. Overexpression of the C-terminus of PC1 had the opposite effects in DNA repair genes, suggesting its regulatory effects in atrial cardiomyocytes through retinoblastoma/E2F. Analyses of human atrial tissue from non-ADPKD patients showed reduced levels of mature PC1, suggesting a broader relevance of impaired PC1 in AF., Conclusions: Impaired PC1 increases in vivo AF inducibility under programmed electrical stimulation and promotes in vitro arrhythmias in hiPSC-aCM and HL-1 cells. Our findings indicate that PC1 protects against DNA damage to reduce AF susceptibility.
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- 2024
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172. Effects of multi-organ crosstalk on the physiology and pathology of adipose tissue.
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Wang S, Liu Y, Chen J, He Y, Ma W, Liu X, and Sun X
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- Humans, Adipose Tissue, Cell Physiological Phenomena, Nutritional Status, Adipocytes, Brown, Diabetes Mellitus, Type 2
- Abstract
In previous studies, adipocytes were found to play an important role in regulating whole-body nutrition and energy balance, and are also important in energy metabolism, hormone secretion, and immune regulation. Different adipocytes have different contributions to the body, with white adipocytes primarily storing energy and brown adipocytes producing heat. Recently discovered beige adipocytes, which have characteristics in between white and brown adipocytes, also have the potential to produce heat. Adipocytes interact with other cells in the microenvironment to promote blood vessel growth and immune and neural network interactions. Adipose tissue plays an important role in obesity, metabolic syndrome, and type 2 diabetes. Dysfunction in adipose tissue endocrine and immune regulation can cause and promote the occurrence and development of related diseases. Adipose tissue can also secrete multiple cytokines, which can interact with organs; however, previous studies have not comprehensively summarized the interaction between adipose tissue and other organs. This article reviews the effect of multi-organ crosstalk on the physiology and pathology of adipose tissue, including interactions between the central nervous system, heart, liver, skeletal muscle, and intestines, as well as the mechanisms of adipose tissue in the development of various diseases and its role in disease treatment. It emphasizes the importance of a deeper understanding of these mechanisms for the prevention and treatment of related diseases. Determining these mechanisms has enormous potential for identifying new targets for treating diabetes, metabolic disorders, and cardiovascular diseases., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Wang, Liu, Chen, He, Ma, Liu and Sun.)
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- 2023
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173. Stellate ganglion instrumentation for pharmacological blockade, nerve recording, and stimulation in patients with ventricular arrhythmias: Preliminary experience.
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Lador A, Wang S, Schurmann PA, Chihara R, Dave AS, and Valderrábano M
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- Male, Humans, Middle Aged, Aged, Female, Arrhythmias, Cardiac, Blood Pressure, Stellate Ganglion, Autonomic Nerve Block methods
- Abstract
Background: Stellate ganglion blockade (SGB) can control ventricular arrhythmias (VAs), but outcomes are unclear. Percutaneous stellate ganglion (SG) recording and stimulation in humans has not been reported., Objective: The purpose of this study was to assess the outcomes of SGB and the feasibility of SG stimulation and recording in humans with VAs., Methods: Two patient cohorts were included-group 1: patients undergoing SGB for drug-refractory VAs. SGB was performed by injection of liposomal bupivacaine. Incidence of VAs at 24 and 72 hours and clinical outcomes were collected; group 2: patients undergoing SG stimulation and recording during VA ablation; a 2-F octapolar catheter was placed at the SG at the C7 level. Recording (30 kHz sampling, 0.5-2 kHz filter) and stimulation (up to 80 mA output, 50 Hz, 2 ms pulse width for 20-30 seconds) was performed., Results: Group 1 included 25 patients [age 59.2 ± 12.8 years; 19 (76%) men] who underwent SGB for VAs. Nineteen patients (76.0%) were free of VA up to 72 hours postprocedure. However, 15 (60.0%) had VAs recurrence for a mean of 5.47 ± 4.52 days. Group 2 included 11 patients (mean age 63 ± 12.7 years; 82.7% men). SG stimulation caused consistent increases in systolic blood pressure. We recorded unequivocal signals with temporal association with arrhythmias in 4 of 11 patients., Conclusion: SGB provides short-term VA control, but has no benefit in the absence of definitive VA therapies. SG recording and stimulation is feasible and may have value to elicit VA and understand neural mechanisms of VA in the electrophysiology laboratory., (Copyright © 2023 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.)
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- 2023
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174. Identification of CD8+ T cell infiltration-related genes and their prognostic values in cervical cancer.
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Shen X, Wang C, Li M, Wang S, Zhao Y, Liu Z, and Zhu G
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Cervical cancer is a female-specific cancer with relatively high morbidity and mortality. As known to all, immune cell infiltrations in the cancer microenvironment are closely related to the cancer diagnosis and prognosis. Here we revealed that the CD8+ T cell infiltration was significantly upregulated in cervical cancer versus normal cervix uteri samples. Through univariate and multivariate cox analyses, we discovered that the CD8+ T cell infiltration was the only independent beneficial factor for the prognosis of cervical cancer. To explore the genes associated with the CD8+ T cell infiltration in cervical cancer, we performed the WGCNA analysis on the differentially expressed genes (DEGs) of cervical cancer versus normal cervix uteri tissues. As a result, 231 DEGs were found to be associated with CD8+ T cell infiltration in cervical cancer. Subsequently, with the Cytoscape analysis, we identified 105 hub genes out of the 231 DEGs. To further explore the genes that might be responsible for the prognosis of cervical cancer, we performed a univariate cox analysis followed by a LASSO assay on the 105 hub genes and located four genes (IGSF6, TLR10, FCRL3, and IFI30) finally. The four genes could be applied to the prediction of the prognosis of cervical cancer, and relatively higher expression of these four genes predicted a better prognosis. These findings contributed to our understanding of the prognostic values of CD8+ T cell infiltration and its associated genes in cervical cancer and thus might benefit future immune-related therapies., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Shen, Wang, Li, Wang, Zhao, Liu and Zhu.)
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- 2022
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175. Impact of big data resources on clinicians' activation of prior medical knowledge.
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Wang S, Yuan J, and Pan C
- Abstract
Background: Activating prior medical knowledge in diagnosis and treatment is an important basis for clinicians to improve their care ability. However, it has not been systematically explained whether and how various big data resources affect the activation of prior knowledge in the big data environment faced by clinicians., Objective: The aim of this study is to contribute to a better understanding on how the activation of prior knowledge of clinicians is affected by a wide range of shared and private big data resources, to reveal the impact of big data resources on clinical competence and professional development of clinicians., Method: Through the comprehensive analysis of extant research results, big data resources are classified as big data itself, big data technology and big data services at the public and institutional levels. A survey was conducted on clinicians and IT personnel in Chinese hospitals. A total of 616 surveys are completed, involving 308 medical institutions. Each medical institution includes a clinician and an IT personnel. SmartPLS version 2.0 software package was used to test the direct impact of big data resources on the activation of prior knowledge. We further analyze their indirect impact of those big data resources without direct impact., Results: (1) Big data quality environment at the institutional level and the big data sharing environment at the public level directly affect activation of prior medical knowledge; (2) Big data service environment at the institutional level directly affects activation of prior medical knowledge; (3) Big data deployment environment at the institutional level and big data service environment at the public level have no direct impact on activation of prior knowledge of clinicians, but they have an indirect impact through big data quality environment and service environment at the institutional level and the big data sharing environment at the public level., Conclusions: Big data technology, big data itself and big data service at the public level and institutional level interact and influence each other to activate prior medical knowledge. This study highlights the implications of big data resources on improvement of clinicians' diagnosis and treatment ability., Competing Interests: The authors declare no conflict of interest., (© 2022 The Author(s).)
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- 2022
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176. Prognostic Value of HLA Class I in Patients with Hepatocellular Carcinoma.
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Pei R, Zhang W, Wang S, Huang X, Zou Y, and Wang G
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- Histocompatibility Antigens Class I analysis, Histocompatibility Antigens Class I metabolism, Humans, Immunohistochemistry, Prognosis, Carcinoma, Hepatocellular pathology, Liver Neoplasms pathology
- Abstract
Background: Downregulation of HLA class I molecules is a major tumor escape mechanism from immune attack. However, its prognostic impact for patients with hepatocellular carcinoma is still unclear. This study aimed to investigate whether HLA class I has prognostic significance in patients with hepatocellular carcinoma., Methods: A cohort of 132 patients with hepatocellular carcinoma was enrolled. HLA class I expression was detected by immunohistochemistry. Levels of HLA class I expression were dichotomized as low and high according to staining intensity or staining percentage of positive tumor cells, respectively. Association of HLA class I expression with clinical characteristics and survival was analyzed., Results: None of the clinical characteristics, including gender, age, virus infection, cirrhosis, AFP, vascular invasion, tumor size and number, was significantly associated with staining percentage of HLA class I or staining intensity (p > 0.05). Low staining percentage of HLA class I was significantly associated with a worse survival (p = 0.011), which was further confirmed by Cox regression hazards model in multivariate analysis (HR 0.416, 95% CI 0.204 - 0.849, p = 0.016). Staining intensity of HLA class I was not significantly associated with survival (p > 0.05)., Conclusions: Expression of HLA class I might be a significant prognostic factor in hepatocellular carcinoma, and downregulation of HLA class I was significantly associated with a worse survival in terms of expression percentage of HLA class I.
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- 2022
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177. Mechanism of Impact of Big Data Resources on Medical Collaborative Networks From the Perspective of Transaction Efficiency of Medical Services: Survey Study.
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Yuan J, Wang S, and Pan C
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- China, Humans, Surveys and Questionnaires, Big Data
- Abstract
Background: The application of big data resources and the development of medical collaborative networks (MCNs) boost each other. However, MCNs are often assumed to be exogenous. How big data resources affect the emergence, development, and evolution of endogenous MCNs has not been well explained., Objective: This study aimed to explore and understand the influence of the mechanism of a wide range of shared and private big data resources on the transaction efficiency of medical services to reveal the impact of big data resources on the emergence and development of endogenous MCNs., Methods: This study was conducted by administering a survey questionnaire to information technology staff and medical staff from 132 medical institutions in China. Data from information technology staff and medical staff were integrated. Structural equation modeling was used to test the direct impact of big data resources on transaction efficiency of medical services. For those big data resources that had no direct impact, we analyzed their indirect impact., Results: Sharing of diagnosis and treatment data (β=.222; P=.03) and sharing of medical research data (β=.289; P=.04) at the network level (as big data itself) positively directly affected the transaction efficiency of medical services. Network protection of the external link systems (β=.271; P=.008) at the level of medical institutions (as big data technology) positively directly affected the transaction efficiency of medical services. Encryption security of web-based data (as big data technology) at the level of medical institutions, medical service capacity available for external use, real-time data of diagnosis and treatment services (as big data itself) at the level of medical institutions, and policies and regulations at the network level indirectly affected the transaction efficiency through network protection of the external link systems at the level of medical institutions., Conclusions: This study found that big data technology, big data itself, and policy at the network and organizational levels interact with, and influence, each other to form the transaction efficiency of medical services. On the basis of the theory of neoclassical economics, the study highlighted the implications of big data resources for the emergence and development of endogenous MCNs., (©Junyi Yuan, Sufen Wang, Changqing Pan. Originally published in the Journal of Medical Internet Research (https://www.jmir.org), 21.04.2022.)
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- 2022
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178. Thermally responsive hydrogel for atrial fibrillation related stroke prevention.
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Hendrickson T, Lupo C, Bauza G, Tavares L, Ingram S, Wang S, Moreno M, Tasciotti E, Valderrabano M, and Taraballi F
- Abstract
Atrial fibrillation induced stroke accounts for up to 15% of all strokes. These strokes are caused approximately 90% of the time by clot formation in the left atrial appendage (LAA). To prevent these clots, the most common approach is to administer blood thinners. However, contraindications prevent some people from being able to have blood thinners. Devices have been developed to seal the LAA to prevent clot formation in these patients. Current devices, such as the LARIAT® tie off the LAA theoretically preventing blood from entering the LAA. These have had limited clinical success mainly due to failure to completely close the LAA leaving holes and orifices for thrombi to form. To overcome this lack of complete closure, many surgeons use off-label approaches, classically filling the LAA filamentous coils, to cover these holes. Although this usually helps largely cover the holes, placement is challenging, the coils can migrate, the holes are not fully closed as there is space within and around the coils that don't fully mold to the LAA geometry. Furthermore, the coils can develop device related thrombi defeating their purpose. Therefore, these are not fully sufficient to complement the closure techniques in closing the LAA. To address limitation of the closure devices and coil sealing of remaining holes, we developed a thermally responsive hydrogel (Thermogel) that solidifies once injected into the LAA to uniformly and fully close off the LAA thus preventing clot formation and device related thrombi. This Thermogel consists of three portions: 1) a structural component composed of thiolated Pluronic F127 for gel to solid transition following injection, 2) Heparin for anticoagulation, and 3) Dopamine for adhesion to the surrounding endothelium in the turbulent flow encountered in cardiovascular applications. Here we have demonstrated that Thermogel, in conjunction with the LARIAT®, is capable of filling the defects in small and large animals through catheter injection. Thermogel was biocompatible and led to atrophy of the LAA at 5 weeks in a large animal model. Given the advantages of this Thermogel for sealing this defect and ability to be delivered through an endovascular approach, Thermogel presents a viable adjuvant to current occlusion-based treatments for sealing cardiovascular defects., Competing Interests: The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Ennio Tasciotti, Francesca Taraballi, Miguel Valderrabano has patent Thermosensitive Hydrogel Sealing of the Left Atrial Appendage to Prevent Thromboembolism in Atrial Fibrillation pending to Ennio Tasciotti, Francesca Taraballi, Miguel Valderrabano.
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- 2022
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179. An integrated analysis of single-cell and bulk transcriptomics reveals EFNA1 as a novel prognostic biomarker for cervical cancer.
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Shen X, Li M, Lei Y, Lu S, Wang S, Liu Z, Wang C, Zhao Y, Wang A, Bi C, and Zhu G
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- Biomarkers, Biomarkers, Tumor genetics, Female, Humans, Prognosis, Transcriptome genetics, Ephrin-A1 genetics, Ephrin-A1 metabolism, Uterine Cervical Neoplasms diagnosis, Uterine Cervical Neoplasms genetics
- Abstract
Cervical cancer is a serious threat to women's health and lives worldwide. The recovery and survival of cervical cancer can be improved by customizing therapy strategies based on individual-specific gene expression patterns. EFNA1 was reported to be dysregulated in many cancers and associated with their overall survivals, but its prognostic value in cervical cancer is still unclear. In this study, we performed analyses on the single-cell and bulk RNA sequencing data to study the role of EFNA1 in cervical cancer. EFNA1 was found to be significantly upregulated in cervical cancer tissue, especially the cancer cell subgroup within tumors, which was verified by immunohistochemistry. Through Cox regressions, we found that high EFNA1 expression is an independent risk factor for cervical cancer. Nomogram analysis indicated that EFNA1 could be a predicting factor for the survival probabilities of cervical cancer. Gene ontology and pathway analyses showed that EFNA1 was involved in many tumorigenesis pathways, protein, and virus productions. These findings suggested that EFNA1 could be a prognostic biomarker and potential therapeutic target for cervical cancer., (© 2022. The Author(s) under exclusive licence to Japan Human Cell Society.)
- Published
- 2022
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180. Venous anatomy of the left ventricular summit: Therapeutic implications for ethanol infusion.
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Tavares L, Fuentes S, Lador A, Da-Wariboko A, Wang S, Schurmann PA, Dave AS, and Valderrábano M
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- Coronary Angiography methods, Coronary Vessel Anomalies diagnosis, Coronary Vessel Anomalies therapy, Female, Humans, Infusions, Intravenous, Male, Middle Aged, Tachycardia, Ventricular physiopathology, Ablation Techniques methods, Coronary Vessel Anomalies complications, Coronary Vessels diagnostic imaging, Electrocardiography methods, Ethanol administration & dosage, Phlebography methods, Tachycardia, Ventricular therapy
- Abstract
Background: Venous ethanol ablation (VEA) is effective for treatment of left ventricular (LV) summit (LVS) arrhythmias. The LVS venous anatomy is poorly understood and has inconsistent nomenclature., Objective: The purpose of this study was to delineate the LVS venous anatomy by selective venography and 3-dimensional (3D) mapping during VEA and by venous-phase coronary computed tomographic angiography (vCTA)., Methods: We analyzed (1) LVS venograms and 3D maps of 53 patients undergoing VEA; and (2) 3D reconstructions of 52 vCTAs, tracing LVS veins., Results: Angiography identified the following LVS veins: (1) LV annular branch of the great cardiac vein (GCV) (19/53); (2) septal (rightward) branches of the anterior ventricular vein (AIV) (53/53); and (3) diagonal branches of the AIV (51/53). Collateral connections between LVS veins and outflow, conus, and retroaortic veins were common. VEA was delivered to target arrhythmias in 38 of 53 septal, 6 of 53 annular, and 2 of 53 diagonal veins. vCTA identified LVS veins (range 1-5) in a similar distribution. GCV-AIV transition could either form an angle close to the left main artery bifurcation (n = 16; 88° ± 13°) or cut diagonally (n = 36; 133°±12°) (P ≤.001). Twenty-one patients had LV annular vein. In 28 patients only septal LVS veins were visualized in vCTA, in 2 patients only diagonal veins and in 22 patients both septal and diagonal veins were seen. In 39 patients the LVS veins reached the outflow tracts and their vicinity., Conclusion: We provide a systematic atlas and nomenclature of LVS veins related to arrhythmogenic substrates. vCTA can be useful for noninvasive evaluation of LVS veins before ethanol ablation., (Copyright © 2021 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.)
- Published
- 2021
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181. Cardiac Afferent Denervation Abolishes Ganglionated Plexi and Sympathetic Responses to Apnea: Implications for Atrial Fibrillation.
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Tavares L, Rodríguez-Mañero M, Kreidieh B, Ibarra-Cortez SH, Chen J, Wang S, Markovits J, Barrios R, and Valderrábano M
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- Afferent Pathways drug effects, Afferent Pathways metabolism, Afferent Pathways physiopathology, Animals, Apnea complications, Apnea metabolism, Apnea physiopathology, Atrial Fibrillation etiology, Atrial Fibrillation metabolism, Atrial Fibrillation physiopathology, Blood Pressure drug effects, Disease Models, Animal, Dogs, Ganglia, Sympathetic metabolism, Ganglia, Sympathetic physiopathology, TRPV Cation Channels agonists, TRPV Cation Channels metabolism, Vagus Nerve physiopathology, Apnea therapy, Atrial Fibrillation prevention & control, Diterpenes pharmacology, Ganglia, Sympathetic drug effects, Heart innervation, Heart Rate drug effects, Sympathectomy, Chemical methods
- Abstract
Background The autonomic nervous system response to apnea and its mechanistic connection to atrial fibrillation (AF) are unclear. We hypothesize that sensory neurons within the ganglionated plexi (GP) play a role. We aimed to delineate the autonomic response to apnea and to test the effects of ablation of cardiac sensory neurons with resiniferatoxin (RTX), a neurotoxic TRPV1 (transient receptor potential vanilloid 1) agonist. Methods Sixteen dogs were anesthetized and ventilated. Apnea was induced by stopping ventilation until oxygen saturations decreased to 80%. Nerve recordings from bilateral vagal nerves, left stellate ganglion, and anterior right GP were obtained before and during apnea, before and after RTX injection in the anterior right GP (protocol 1, n=7). Atrial effective refractory period and AF inducibility on single extrastimulation were assessed before and during apnea, and before and after intrapericardial RTX administration (protocol 2, n=9). GPs underwent immunohistochemical staining for TRPV1. Results Apnea increased anterior right GP activity, followed by clustered crescendo vagal bursts synchronized with heart rate and blood pressure oscillations. On further oxygen desaturation, a tonic increase in stellate ganglion activity and blood pressure ensued. Apnea-induced effective refractory period shortening from 110.20±31.3 ms to 90.6±29.1 ms ( P<0.001), and AF induction in 9/9 dogs versus 0/9 at baseline. After RTX administration, increases in GP and stellate ganglion activity and blood pressure during apnea were abolished, effective refractory period increased to 126.7±26.9 ms ( P=0.0001), and AF was not induced. Vagal bursts remained unchanged. GP cells showed cytoplasmic microvacuolization and apoptosis. Conclusions Apnea increases GP activity, followed by vagal bursts and tonic stellate ganglion firing. RTX decreases sympathetic and GP nerve activity, abolishes apnea's electrophysiological response, and AF inducibility. Sensory neurons play a role in apnea-induced AF.
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- 2019
- Full Text
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182. Nanoparticles administered intrapericardially enhance payload myocardial distribution and retention.
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Segura-Ibarra V, Cara FE, Wu S, Iruegas-Nunez DA, Wang S, Ferrari M, Ziemys A, Valderrabano M, and Blanco E
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- Animals, Boron Compounds administration & dosage, Boron Compounds pharmacokinetics, Drug Administration Routes, Female, Fluorescent Dyes administration & dosage, Fluorescent Dyes pharmacokinetics, Lactic Acid pharmacokinetics, Polyglycolic Acid pharmacokinetics, Polylactic Acid-Polyglycolic Acid Copolymer, Rabbits, Lactic Acid administration & dosage, Myocardium metabolism, Nanoparticles administration & dosage, Polyglycolic Acid administration & dosage
- Abstract
Pharmacological therapies for cardiovascular diseases are limited by short-term pharmacokinetics and extra-cardiac adverse effects. Improving delivery selectivity specifically to the heart, wherein therapeutic drug levels can be maintained over time, is highly desirable. Nanoparticle (NP)-based pericardial drug delivery could provide a strategy to concentrate therapeutics within a unique, cardiac-restricted compartment to allow sustained drug penetration into the myocardium. Our objective was to explore the kinetics of myocardial penetration and retention after pericardial NP drug delivery. Fluorescently-tagged poly(lactic-co-glycolic acid) (PLGA) NPs were loaded with BODIPY, a fluorophore, and percutaneously administered into the pericardium via subxiphoid puncture in rabbits. At distinct timepoints hearts were examined for presence of NPs and BODIPY. PLGA NPs were found non-uniformly distributed on the epicardium following pericardial administration, displaying a half-life of ~2.5days in the heart. While NPs were mostly confined to epicardial layers, BODIPY was capable of penetrating into the myocardium, resulting in a transmural gradient. The distinct architecture and physiology of the different regions of the heart influenced BODIPY distribution, with fluorophore penetrating more readily into atria than ventricles. BODIPY proved to have a long-term presence within the heart, with a half-life of ~7days. Our findings demonstrate the potential of utilizing the pericardial space as a sustained drug-eluting reservoir through the application of nanoparticle-based drug delivery, opening several exciting avenues for selective and prolonged cardiac therapeutics., (Copyright © 2017 Elsevier B.V. All rights reserved.)
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- 2017
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183. Skull metastasis from follicular thyroid carcinoma: report of three cases and review of literature.
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Shen J, Wang S, Zhao X, Shao X, Jiang X, Dai Y, Xu S, and Pan X
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- Adenocarcinoma, Follicular chemistry, Adenocarcinoma, Follicular surgery, Aged, Biomarkers, Tumor analysis, Biopsy, Cranial Irradiation, Craniotomy, Disease Progression, Fatal Outcome, Female, Hormone Replacement Therapy, Humans, Immunohistochemistry, Magnetic Resonance Imaging, Male, Middle Aged, Radiotherapy, Adjuvant, Skull Neoplasms chemistry, Skull Neoplasms surgery, Thyroid Neoplasms chemistry, Thyroid Neoplasms surgery, Thyroidectomy, Thyroxine administration & dosage, Time Factors, Tomography, X-Ray Computed, Treatment Outcome, Adenocarcinoma, Follicular secondary, Skull Neoplasms secondary, Thyroid Neoplasms pathology
- Abstract
Three patients' medical history, clinical manifestation, imaging characteristic, therapy and prognosis of calvaria metastasis from follicular thyroid carcinoma (FTC) in our hospital were retrospectively analyzed by reviewing medical literature. In case one, the tumor in frontal bone and fossa orbital was total resected, no further treatment was performed, the patient gave up on therapy and died of extensive metastasis at 22 months after the initial operation. In case two, the tumor in parietal and occipital bone was total resected, the subtotal resection of bilateral thyroid gland and isthmus was performed and combined with therapy of Levothyroxine and (131)I radio-iodine therapy, no evidence of tumor recurrence at 30 months after the primary operation. In case three, the tumor in occipital bone was gross total resected, total resection of bilateral thyroid gland and clearance of lymph node was performed after two months, adjunctive therapy with Levothyroxine, (131)I radio-iodine and skull radiotherapy, no evidence of tumor recurrence at 21 months after the primary operation. Correct diagnosis of calvaria metastasis from FTC preoperative is difficult because it's rarity, patients can survive for years after synthetic therapy including total resection of metastatic tumor, radical operation of thyroid carcinoma, adjunctive therapy of Levothyroxine, (131)I radio-iodine and skull radiotherapy.
- Published
- 2015
184. Limiting sarcolemmal Na+ entry during resuscitation from ventricular fibrillation prevents excess mitochondrial Ca2+ accumulation and attenuates myocardial injury.
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Wang S, Radhakrishnan J, Ayoub IM, Kolarova JD, Taglieri DM, and Gazmuri RJ
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- Animals, Anti-Arrhythmia Agents pharmacology, Anti-Arrhythmia Agents therapeutic use, Blood Pressure, Coronary Circulation, Disease Models, Animal, Heart Ventricles metabolism, Lidocaine pharmacology, Lidocaine therapeutic use, Male, Mitochondria, Heart drug effects, Myocardial Reperfusion Injury etiology, Myocardial Reperfusion Injury metabolism, Myocardial Reperfusion Injury physiopathology, Myocardium pathology, Rats, Rats, Sprague-Dawley, Research Design, Sarcolemma drug effects, Sodium Channel Blockers pharmacology, Sodium Channel Blockers therapeutic use, Sodium-Hydrogen Exchanger 1, Sodium-Hydrogen Exchangers antagonists & inhibitors, Sodium-Hydrogen Exchangers metabolism, Sodium-Potassium-Exchanging ATPase metabolism, Troponin I blood, Ventricular Fibrillation complications, Ventricular Fibrillation drug therapy, Ventricular Fibrillation metabolism, Ventricular Fibrillation physiopathology, Ventricular Function, Left, Calcium metabolism, Mitochondria, Heart metabolism, Myocardial Reperfusion Injury prevention & control, Myocardium metabolism, Resuscitation, Sarcolemma metabolism, Sodium metabolism, Ventricular Fibrillation therapy
- Abstract
Background: intracellular Na+ accumulation during ischemia and reperfusion leads to cytosolic Ca2+ overload through reverse-mode operation of the sarcolemmal Na+ -Ca2+ exchanger. Cytosolic Ca2+ accumulation promotes mitochondrial Ca2+ (Ca2+ m) overload, leading to mitochondrial injury. We investigated whether limiting sarcolemmal Na+ entry during resuscitation from ventricular fibrillation (VF) attenuates Ca2+ m overload and lessens myocardial dysfunction in a rat model of VF and closed-chest resuscitation., Methods: hearts were harvested from 10 groups of 6 rats each representing baseline, 15 min of untreated VF, 15 min of VF with chest compression given for the last 5 min (VF/CC), and 60 min postresuscitation (PR). VF/CC and PR included four groups each randomized to receive before starting chest compression the new NHE-1 inhibitor AVE4454B (1.0 mg/kg), the Na+ channel blocker lidocaine (5.0 mg/kg), their combination, or vehicle control. The left ventricle was processed for intracellular Na+ and Ca2+ m measurements., Results: limiting sarcolemmal Na+ entry attenuated cytosolic Na+ increase during VF/CC and the PR phase and prevented Ca2+ m overload yielding levels that corresponded to 77% and 71% of control hearts at VF/CC and PR, without differences among specific Na+ -limiting interventions. Limiting sarcolemmal Na+ entry attenuated reductions in left ventricular compliance during VF and prompted higher mean aortic pressure (110 +/- 7 vs. 95 +/- 11 mmHg, P < 0.001) and higher cardiac work index (159 +/- 34 vs. 126 +/- 29 g x m x min(-1) x kg(-1), P < 0.05) with lesser increases in circulating cardiac troponin I at 60 min PR., Conclusions: Na+ -limiting interventions prevented excess Ca2+ m accumulation induced by ischemia and reperfusion and ameliorated myocardial injury and dysfunction.
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- 2007
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185. [Experimental study on hemostatic effect of flos sophorae and its extracts].
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Li H, Yuan GD, Jin YH, Li R, Wang L, and Wang S
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- Animals, Bleeding Time, Blood Coagulation drug effects, Capillary Permeability drug effects, Drugs, Chinese Herbal chemistry, Female, Flowers chemistry, Male, Mice, Quercetin isolation & purification, Quercetin pharmacology, Rats, Rats, Wistar, Rutin isolation & purification, Rutin pharmacology, Tannins isolation & purification, Tannins pharmacology, Drugs, Chinese Herbal pharmacology, Hemostatics pharmacology, Sophora chemistry
- Abstract
Objective: To compare the hemostatic effect of Flos Sophorae in crude, parched and carbonized forms and its extracts, including rutin, quercetin and tannin., Methods: All the testing samples were orally administered to the experimental animals for 5 days, then the bleeding time (BT), coagulation time (CT), platelet count and capillary permeability (CP) in the treated mice were tested, and the prothrombin time (PT), fibrinogen (FBG) content and platelet aggregation rate (PAR) in the treated rats were determined., Results: All the samples could lower the CP, BT and CT in mice and also decrease the plasma PT in rats. All three forms of Flos Sophorae could increase FBG in rats, while the three extracts of it could inhibit the PAR in rats obviously. In addition, rutin had the effect of raising the platelet count., Conclusion: All the three forms and three extracts of Flos Sophorae have hemostatic effect, the effect of parched and carbonized form is higher than that of crude drug. The mechanism of the hemostatic effect of the six kinds of sample might be various.
- Published
- 2004
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