151. Petiolins A-C, phloroglucinol derivatives from Hypericum pseudopetiolatum var. kiusianum.
- Author
-
Tanaka N, Kubota T, Ishiyama H, Araki A, Kashiwada Y, Takaishi Y, Mikami Y, and Kobayashi J
- Subjects
- Animals, Antifungal Agents isolation & purification, Cell Line, Tumor, Cell Proliferation drug effects, Drug Screening Assays, Antitumor, Humans, Leukemia L1210 pathology, Magnetic Resonance Spectroscopy methods, Mice, Microbial Sensitivity Tests, Models, Molecular, Molecular Structure, Phloroglucinol isolation & purification, Stereoisomerism, Antifungal Agents chemistry, Antifungal Agents pharmacology, Hypericum chemistry, Leukemia L1210 drug therapy, Phloroglucinol analogs & derivatives, Phloroglucinol chemistry, Phloroglucinol pharmacology, Trichophyton drug effects
- Abstract
Two new phloroglucinol derivatives possessing chromane skeleton, petiolins A (1) and B (2), and a new phloroglucinol derivative containing a dihydrofuran ring, petiolin C (3), were isolated from aerial parts of Hypericum pseudopetiolatum var. kiusianum. The gross structures of 1-3 were elucidated by spectroscopic data, and the relative stereochemistry of 3 was elucidated by NOESY data. Petiolins A-C (1-3) showed modest cytotoxicity, while petiolin C (3) exhibited antifungal activity.
- Published
- 2008
- Full Text
- View/download PDF