82 results on '"T. Mizumoto"'
Search Results
52. Differential susceptibility to immune cytolysis of 3T3 cells in monolayer and in suspension
- Author
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T Mizumoto, Kazuhiro Ishii, A Matsumoto, and M Hanaoka
- Subjects
Absorption (skin) ,Biology ,Antibodies ,3T3 cells ,Cell Line ,Antigen-Antibody Reactions ,Antigen ,Cell Adhesion ,medicine ,Antigens ,Cell adhesion ,Antiserum ,Cell Membrane ,Complement System Proteins ,Cell Biology ,Cytotoxicity Tests, Immunologic ,Molecular biology ,Clone Cells ,Cell biology ,medicine.anatomical_structure ,Lytic cycle ,Cell culture ,Microscopy, Electron, Scanning ,biology.protein ,Adsorption ,Antibody - Abstract
The sensitivity of 3T3 cells to immune cytolysis with antiserum and complement was much different between the substratum-attached and the suspended cells. The former was highly sensitive, while the latter was resistant to immune cytolysis. The results of absorption tests of antiserum indicated that this lytic resistance was not ascribed to the change in amount of surface antigens in the suspended cells. Possible mechanisms for the lytic resistance were discussed.
- Published
- 1977
53. [Systemic sclerosis: (I) A review of 20 cases (author's transl)]
- Author
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I, Takashima, T, Mizumoto, A, Takaghi, O, Onishi, and K, Murakami
- Subjects
Adult ,Male ,Scleroderma, Systemic ,Adolescent ,Blood Sedimentation ,Middle Aged ,Antistreptolysin ,Menstruation ,Japan ,Rheumatoid Factor ,Humans ,Female ,gamma-Globulins ,Child - Published
- 1974
54. [Three cases of ischemic colitis in young adults]
- Author
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F, Inoue, K, Kitamura, T, Mizumoto, H, Furukawa, and H, Uchino
- Subjects
Adult ,Ischemia ,Fiber Optic Technology ,Humans ,Female ,Colonoscopy ,Colitis - Published
- 1986
55. Increases in dissolution rate of nifedipine by roll mixing with polyvinylpyrrolidone
- Author
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Y, Nozawa, T, Mizumoto, and F, Higashide
- Subjects
Nifedipine ,Solubility ,Chemistry, Pharmaceutical ,Drug Compounding ,Povidone - Published
- 1986
56. [Erythema elevatum diutinum, a variant of cutaneous vasculitis]
- Author
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T, Mizumoto, A, Ohkawara, O, Ohnishi, T, Aoyagi, and Y, Miura
- Subjects
Male ,Erythema ,Foot ,Humans ,Vasculitis, Leukocytoclastic, Cutaneous ,Ear, External ,Middle Aged ,Dapsone ,Dexamethasone ,Penis - Abstract
A 59 year-old man with erythema elevatum diutinum which we consider a variant of cutaneous vasculitis, is reported. An excellent therapeutic effect with Dapsone (DDS) was obtained in this case. Clinical and histopathological similarities among erythema elevatum diutinum, extracellular cholesterosis and granuloma annulare are discussed.
- Published
- 1977
57. Topical application of potent glucocorticoids augments epidermal beta-adrenergic adenylate cyclase response in vivo
- Author
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S, Kajita, H, Iizuka, M, Hirokawa, M, Tsutsui, and T, Mizumoto
- Subjects
Betamethasone Valerate ,Clobetasol ,Hydrocortisone ,Swine ,Ultraviolet Rays ,Administration, Topical ,Anti-Inflammatory Agents ,Animals ,Epidermis ,Adenylyl Cyclases - Abstract
The effects of topical application of glucocorticoids on the epidermal beta-adrenergic adenylate cyclase response were investigated. A significant increase in this receptor response was observed 24 h following topical application of potent glucocorticoid ointments (0.12% betamethasone-17-valerate, 0.05% clobetasol-17-propionate). The application of a relatively weak glucocorticoid, hydrocortisone-17-butyrate, revealed no augmentation effect. There was no significant difference in other adenylate cyclase responses (adenosine-, and histamine-) between control and glucocorticoid-treated epidermis. UVB irradiation is known to augment the beta-adrenergic response of epidermis. Comparison of the effects revealed that topical glucocorticoid treatment had less effect than UVB irradiation, and when the UVB irradiation was combined with glucocorticoid treatment, the beta-adrenergic augmentation effect was not enhanced. Cyclic AMP phosphodiesterase activities were not significantly altered by the glucocorticoid-, UVB-, or combined treatments. Our data indicate that epidermal beta-adrenergic adenylate cyclase response is affected by topical application of 'potent' glucocorticoids in vivo. Although the effect is weaker than that induced by UVB irradiation, we believe the system might be a useful tool for dissecting the glucocorticoidal potency of topical preparations using the epidermal keratinocyte response in vivo.
- Published
- 1986
58. [Changes of IgA in pyoderma gangrenosum (author's transl)]
- Author
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Y, Miyachi, M, Ozaki, E, Tamaki, M, Sakurai, K, Ikai, M, Takigawa, J, Komura, T, Kanoh, and T, Mizumoto
- Subjects
Adult ,Gangrene ,Male ,Pyoderma ,Humans ,Female ,Middle Aged ,Aged ,Immunoglobulin A - Published
- 1980
59. The localization of cyclic nucleotides in the human epidermis: an immunohistochemical study
- Author
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T, Mizumoto and A, Ohkawara
- Subjects
Epidermal Cells ,Cyclic AMP ,Immunologic Techniques ,Humans ,Psoriasis ,Cell Differentiation ,Epidermis ,Cyclic GMP ,Cell Division - Abstract
Immunohistochemical localizations of 3',5'-cyclic AMP (cAMP) and 3',5'-cyclic GMP (cGMP) were performed in the involved and non-involved epidermis of psoriasis and in the normal controls. The following results were obtained: 1. In the normal epidermis, cAMP was located in the cytoplasm throughout the epidermis but it was more pronounced in its upper portions, especially in the granular layers. Occasionally it was also observed in the nuclear membrane. However, cGMP was located mainly in the cytoplasm of the lower layers of epidermis, though the fluorescence was less pronounced as compared with that of cAmP. 2. In the noninvolved psoriatic epidermis, the localization pattern of cAMP was basically similar to that in the normal control, but its fluorescence seemed more pronounced. The fluorescence of cGMP was essentially the same as that in the normal control. 3. In the involved psoriatic epidermis, the distribution pattern of cAMP was essentially the same as that in the normal control, but its fluorescence seemed more pronounced. Marked increase in the fluorescence of cGMP was observed in the involved psoriatic epidermis, though it was much more pronounced in its lower portions.
- Published
- 1980
60. [48, XXYY Klinefelter's syndrome with recurrent leg ulcer (author's transl)]
- Author
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K, Yamamoto, T, Mizumoto, A, Ohkawara, T, Takamura, A, Okuno, and Y, Shimomura
- Subjects
Adult ,Male ,Klinefelter Syndrome ,Recurrence ,Karyotyping ,Leg Ulcer ,Humans - Published
- 1981
61. [Successful removal of ball thrombus in the left atrium]
- Author
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T, Mizumoto, H, Chigusa, M, Okabe, K, Takeda, I, Yada, and M, Kusagawa
- Subjects
Male ,Heart Diseases ,Echocardiography ,Heart Valve Prosthesis ,Humans ,Mitral Valve Stenosis ,Female ,Thrombosis ,Heart Atria ,Middle Aged - Abstract
Two cases of left atrial ball thrombus associated with severe mitral stenosis in which echocardiography provided the clue to the diagnosis preoperatively were reported. First case was a 58 years old man who was admitted because of dyspnea and frequent syncopal attacks. An echocardiographic examination revealed a tight mitral stenosis and a floating ball thrombus in the left atrium. Under the extracorporeal circulation, the ball thrombus, 30 X 40 mm in size, weight 20 g was taken out. The other case was a 51 years old woman who had undergone surgery for closed mitral commissurotomy 14 years ago. She had a episode of syncope attack and a sudden loss of consciousness. The removed thrombus was 20 X 26 mm in size and weighed 5 g. Their cut surfaces showed an laminated structure in both cases. These mitral valves were replaced by Björk-Shiley prosthetic valves.
- Published
- 1989
62. [Effects of the calcium ion on the wound healing process]
- Author
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T, Mizumoto
- Subjects
Male ,Wound Healing ,Calmodulin ,Guinea Pigs ,Granulation Tissue ,Animals ,Calcium - Abstract
The present study was undertaken to elucidate the effect of calcium ion on the granulation tissue formation during wound healing. Male guinea pigs of Pilbright strain were chosen as the experimental animal. An appropriate open wound was aseptically made on the dorsum of the guinea pigs, which was then equipped with a sterile Teflon-cylinder. The amounts of granulation tissues developed within the cylinder were determined during 10 day period of the observation. In addition, various concentrations of CaCl2 were applied on the wound surface for up to 3 days after the wounding. Calmodulin contents in the granulation tissue were also determined using calmodulin-deficient phosphodiesterase prepared from bovine heart. Purified pig skin epidermal calmodulin was used as the standard. The results obtained were as follows: The amount of the granulation tissue increased in a stepwise manner during 3, 5, 7, and 10 days after the wounding. Calmodulin content in the granulation tissue was maximal on the day 3 after the wounding, waned on the day 5, and remained low on the days 7 and 10. A significant augmentation of the granulation tissue production as well as of calmodulin content was observed when CaCl2 was applied on the wound surface during 3 days after the wounding. These results suggest that calcium ion might have a significant role on granulation tissue development, possibly through the Ca++-calmodulin system, during early stages of wound healing process.
- Published
- 1987
63. [Symposium I: The skin and cyclic AMP]
- Author
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Y, Nishizuka, T, Okubo, A, Okawara, T, Mizumoto, and O, Onishi
- Subjects
Neoplasms ,Cyclic AMP ,Humans ,Melanocytes ,Psoriasis ,Glycogen ,Adenylyl Cyclases ,Skin - Published
- 1974
64. Die Bedeutung von Calmodulin und Kalzium für die Wundheilung
- Author
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W. Vanscheidt, H. Wokalek, T. Mizumoto, R. Niedner, and D. Marmé
- Abstract
Calmodulin (CaM) ist ein multifunktionales kalziumabhangiges Modulatorprotein, das in nahezu allen Eukaryozyten gefunden wird (Cheung 1980). Als zentraler Mediator des zellularen Kalzium-Signals steuert es z.B. den Ca2+-Transport, die Neurotransmitterausschuttung, Steroidsynthese, Mitosen und Zellbewegungen. Es reguliert Enzymaktivitaten, wie z. B. die Adenylatzyklase, cAMP-Phosphodiesterase (PDE) und Ca2+-Mg2+-ATPase, Phosphorylase-Kinase, Phospholipase A2 und NAD-Kinase (Marme 1981).
- Published
- 1988
65. [Minocycline]
- Author
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Y, Miura, T, Mizumoto, and H, Shibaki
- Subjects
Adult ,Male ,Adolescent ,Chemical Phenomena ,Staphylococcus ,Furunculosis ,Blood Proteins ,Microbial Sensitivity Tests ,Middle Aged ,Tetracycline ,Skin Diseases ,Chemistry ,Blister ,Acne Vulgaris ,Humans ,Female ,Aged - Published
- 1969
66. Sigma-z random forest, classification and confidence.
- Author
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A Fornaser, M De Cecco, P Bosetti, T Mizumoto, and K Yasumoto
- Subjects
CLASSIFICATION ,MACHINE learning ,CONFIDENCE ,TRACE elements ,PROBABILITY theory - Abstract
Machine learning is a promising research topic that has recently achieved remarkable results, leading to the substitution of more traditional methods with automatically learned solutions. Some recent works have begun to highlight how a machine-learned model can be tricked by just applying small variations to the data, resulting in completely erroneous outcomes. Such behaviour can be traced to two elements: the lack of any metrological characterization of the inputs passed to the model, such as the uncertainty of the data, and the lack of an assessment of the reliability of the results. This paper tackles both these elements, considering the case of random forest model and proposing a method for assessing a confidence probability as an estimator for classification reliability. This considers the original classification structure, leaving it untouched, and the distribution of the training datasets. An overlaying structure statistically combines the two, and also includes in the process the propagation of feature uncertainties as a further element deriving from input measurements. The new classification outcome is a vector of probabilities that define how reliably a feature entry can be assigned, or not, to each of the considered classes, independently of others. In this new structure, an additional classification result naturally becomes available: the unclassifiable feature entry. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
67. CHANGES OF ABSORPTION IN LPE GROWN (GdBiCa)3Fe5O12 FILMS BY Ar SPUTTER-ETCHING
- Author
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K.Suriyathumrong SANTI, T. MIZUMOTO, and Y. NAITO
- Subjects
Argon ,Materials science ,Doping ,Analytical chemistry ,chemistry.chemical_element ,Condensed Matter Physics ,Electronic, Optical and Magnetic Materials ,Ion ,Lattice constant ,chemistry ,Sputtering ,Etching (microfabrication) ,medicine ,Ferric ,Electrical and Electronic Engineering ,Absorption (electromagnetic radiation) ,Instrumentation ,medicine.drug - Abstract
Change of optical absorption after etching was experimentally studied on Ca and Bi doped GdIG films. When argon sputter-etching was performed on as-grown films for a period of time, absorption decreased to the same level as when reduction treatment was performed in Fe(OH)2 solution. Measurement of lattice constant showed that it increased up to a certain value in both cases of sputter-etching and reducing treatment. Further sputter-etching resulted in the increase of loss, while lattice constant remained unchanged. Change of absorption can be explained by changes in valency of ferric ions, whereas change of lattice constant is mainly attributed to reduction of Pb4+ to Pb2+.
- Published
- 1987
68. Imaging Polarimeter for a Sub-MeV Gamma-Ray All-sky Survey Using an Electron-tracking Compton Camera.
- Author
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S. Komura, A. Takada, Y. Mizumura, S. Miyamoto, T. Takemura, T. Kishimoto, H. Kubo, S. Kurosawa, Y. Matsuoka, K. Miuchi, T. Mizumoto, Y. Nakamasu, K. Nakamura, M. Oda, J. D. Parker, T. Sawano, S. Sonoda, T. Tanimori, D. Tomono, and K. Yoshikawa
- Subjects
COMPTON imaging ,POLARIMETRY ,CELESTIAL mechanics ,GAMMA ray bursts ,X-ray telescopes ,POLARIZATION (Nuclear physics) - Abstract
X-ray and gamma-ray polarimetry is a promising tool to study the geometry and the magnetic configuration of various celestial objects, such as binary black holes or gamma-ray bursts (GRBs). However, statistically significant polarizations have been detected in few of the brightest objects. Even though future polarimeters using X-ray telescopes are expected to observe weak persistent sources, there are no effective approaches to survey transient and serendipitous sources with a wide field of view (FoV). Here we present an electron-tracking Compton camera (ETCC) as a highly sensitive gamma-ray imaging polarimeter. The ETCC provides powerful background rejection and a high modulation factor over an FoV of up to 2π sr thanks to its excellent imaging based on a well-defined point-spread function. Importantly, we demonstrated for the first time the stability of the modulation factor under realistic conditions of off-axis incidence and huge backgrounds using the SPring-8 polarized X-ray beam. The measured modulation factor of the ETCC was 0.65 ± 0.01 at 150 keV for an off-axis incidence with an oblique angle of 30° and was not degraded compared to the 0.58 ± 0.02 at 130 keV for on-axis incidence. These measured results are consistent with the simulation results. Consequently, we found that the satellite-ETCC proposed in Tanimori et al. would provide all-sky surveys of weak persistent sources of 13 mCrab with 10% polarization for a 10
7 s exposure and over 20 GRBs down to a 6 × 10−6 erg cm−2 fluence and 10% polarization during a one-year observation. [ABSTRACT FROM AUTHOR]- Published
- 2017
- Full Text
- View/download PDF
69. Optical nonreciprocal devices based on magneto-optical phase shift in silicon photonics.
- Author
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Y Shoji, K Miura, and T Mizumoto
- Subjects
MAGNETOOPTICS ,OPTICAL isolators ,OPTICAL circulators ,PHASE shifters ,OPTICAL devices - Abstract
Silicon waveguide optical nonreciprocal devices that use the magneto-optical phase shift are reviewed. The phase shift caused by the first-order magneto-optical effect is effective in realizing optical nonreciprocal devices on semiconductor waveguide platforms. In a silicon-on-insulator waveguide, the low refractive index of the buried oxide layer contributes to the large penetration of the optical field into a magneto-optical material used as an over-cladding layer. This enhances the magneto-optical phase shift and, hence, contributes greatly to reducing the device footprint. A surface-activated direct bonding technique plays a key role in the fabrication of magneto-optical nonreciprocal devices. This technique makes it possible to use a high-quality single-crystalline magneto-optical garnet that exhibits a large first-order magneto-optical effect. An optical isolator based on the magneto-optical phase shift was demonstrated in a silicon waveguide with an optical isolation ratio as high as 30 dB and an insertion loss of 13 dB at a wavelength of λ = 1548 nm. Furthermore, a four-port optical circulator was demonstrated with maximum isolation ratios of 33.5 and 29.1 dB in the cross and bar ports, respectively, at λ = 1543 nm. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
70. AN ELECTRON-TRACKING COMPTON TELESCOPE FOR A SURVEY OF THE DEEP UNIVERSE BY MeV GAMMA-RAYS.
- Author
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T. Tanimori, H. Kubo, A. Takada, S. Iwaki, S. Komura, S. Kurosawa, Y. Matsuoka, K. Miuchi, S. Miyamoto, T. Mizumoto, Y. Mizumura, K. Nakamura, S. Nakamura, M. Oda, J. D. Parker, T. Sawano, S. Sonoda, T. Takemura, D. Tomono, and K. Ueno
- Subjects
GAMMA rays ,COMPTON scattering ,GAMMA ray astronomy ,ELECTRON scattering ,ELECTRON research - Abstract
Photon imaging for MeV gammas has serious difficulties due to huge backgrounds and unclearness in images, which originate from incompleteness in determining the physical parameters of Compton scattering in detection, e.g., lack of the directional information of the recoil electrons. The recent major mission/instrument in the MeV band, Compton Gamma Ray Observatory/COMPTEL, which was Compton Camera (CC), detected a mere ∼30 persistent sources. It is in stark contrast with the ∼2000 sources in the GeV band. Here we report the performance of an Electron-Tracking Compton Camera (ETCC), and prove that it has a good potential to break through this stagnation in MeV gamma-ray astronomy. The ETCC provides all the parameters of Compton-scattering by measuring 3D recoil electron tracks; then the Scatter Plane Deviation (SPD) lost in CCs is recovered. The energy loss rate (dE/dx), which CCs cannot measure, is also obtained, and is found to be helpful to reduce the background under conditions similar to those in space. Accordingly, the significance in gamma detection is improved severalfold. On the other hand, SPD is essential to determine the point-spread function (PSF) quantitatively. The SPD resolution is improved close to the theoretical limit for multiple scattering of recoil electrons. With such a well-determined PSF, we demonstrate for the first time that it is possible to provide reliable sensitivity in Compton imaging without utilizing an optimization algorithm. As such, this study highlights the fundamental weak-points of CCs. In contrast we demonstrate the possibility of ETCC reaching the sensitivity below 1 × 10
−12 erg cm−2 s−1 at 1 MeV. [ABSTRACT FROM AUTHOR]- Published
- 2015
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71. I. ANNUAL SUMMARY OF EXPERIMENTAL RESEARCH ACTIVITIES. I-1. PROJECT RESEARCHES
- Author
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Sakurai, Y.
- Abstract
PR6-1 Establishment of characterization estimation method in BNCT irradiation field using Bonner sphere and ionization chamber (V)/ Y. Sakurai et al. (R3P6-1) [53], PR6-2 Study on New Type of Neutron Energy Spectrometer for BNCT/ K. Watababe et al. (R3P6-2) [54], PR6-3 Development and demonstration of Bonner sphere spectrometer for intense neutrons/ A. Masuda (R3P6-3) [55], PR6-4 Improvement of the SOF detector system for energy-dependent discrimination and long-term stability/ M. Ishikawa et al. (R3P6-4) [56], PR6-5 First Direct Observation of Boron Dose Distribution with a Boron-added Liquid Scintillator/ A. Nohtomi et al. (R3P6-5) [57], PR6-6 Development of Absolute Epi-thermal Neutron Flux Intensity Monitor for BNCT/ I. Murata et al. (R3P6-6) [58], PR6-7 Study for microdosimetry using silicon-on-insulator microdosimeter in the BNCT irradiation field (V)/ Y. Sakurai et al. (R3P6-8) [59], PR6-8 Measurement of BNCT beam component fluence with multi imaging plate system./ K. Tanaka et al. (R3P6-10) [60], PR6-9 Development of 2D Real-Time Neutron Imaging System in the BNCT Irradiation Field/ S. Uno et al. (R3P6-11) [61], PR6-10 Measurements of Neutron Fluence and Gamma ray Distribution using Thermoluminescence Slabs/ K. Shinsho et al. (R3P6-12) [62], PR6-11 Development and evaluation of 3D gel dosimeter for the measurement of dose distribution in BNCT/ S. Hayashi, et al. (R3P6-14) [63], PR6-12 Establishment of beam-quality estimation method in BNCT irradiation field using dual phantom technique (V)/ Y. Sakurai et al. (R3P6-15) [64], PR6-13 Development of real-time thermal neutron monitor for BNCT/ H. Tanaka et al. (R3P6-16) [65], PR6-14 Quantitative Measurement of 478 keV Prompt Gamma-rays of Boron-neutron Capture Reaction with the ETCC/ T. Mizumoto et al. (R3P6-17) [66], PR6-15 Evaluation of neutron irradiation fields for semiconductor device irradiation/ H. Tanaka et al. (R3P6-19) [67], PR6-16 Optimization of Bolus Shape for Boron Neutron Capture Therapy --Examination Using Simple Shaped Phantom for Experimental Verification--/ T. Takata et al. (R3P6-20) [68], PR6-17 Annealing properties of boric acid infused PVA-GTA-I gel irradiated with neutrons/ H. Yasuda et al. (R3P6-22) [69], PR6-18 Three dimentional model for pre-clinical assessments in BNCT/ K. Igawa et al. (R3P6-23) [70], In case that corrections are made, an errata will be provided in the following webpage: https://www.rri.kyoto-u.ac.jp/PUB/report/PR/ProgRep2021/ProgRep2021.html
- Published
- 2022
72. Spectral Broadening in an InGaAsP Optical Waveguide with χ(3) Nonlinearity Including Two Photon Absorption
- Author
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Matsuura, Keigo and Tomita, Isao
- Subjects
Spectral Broadening ,χ(3) Nonlinearity ,InGaAsP Waveguide - Abstract
We have studied a method to widen the spectrum of optical pulses that pass through an InGaAsP waveguide for application to broadband optical communication. In particular, we have investigated the competitive effect between spectral broadening arising from nonlinear refraction (optical Kerr effect) and shrinking due to two photon absorption in the InGaAsP waveguide with χ(3) nonlinearity. The shrunk spectrum recovers broadening by the enhancement effect of the nonlinear refractive index near the bandgap of InGaAsP with a bandgap wavelength of 1490 nm. The broadened spectral width at around 1525 nm (196.7 THz) becomes 10.7 times wider than that at around 1560 nm (192.3 THz) without the enhancement effect, where amplified optical pulses with a pulse width of ∼ 2 ps and a peak power of 10 W propagate through a 1-cm-long InGaAsP waveguide with a cross-section of 4 (μm)2., {"references":["G. P. Agrawal, Fiber-Optic Communication Systems, 4th ed., New\nJersey: Wiley&Sons, 2010.","C. Lin ed., Broadband Optical Access Networks and Fiber-to-the-Home:\nSystems Technologies and Deployment Strategies, 1st ed., West Sussex:\nWiley&Sons, 2006.","J. Darja, M. J. Chan, M. Sugiyama, and Y. Nakano, \"Four channel DFB\nlaser array with integrated combiner for 1.55 μm CWDM systems by\nMOVPE selective area growth\", IEICE Electronic Express 3 (24), 2006,\npp.522-528.","W. Li, X. Zhang, and J. Yao, \"Experimental demonstration of a\nmulti-wavelength distributed feedback semiconductor laser array with\nan equivalent chirped grating profile based on the equivalent chirp\ntechnology\", Opt. Exp. 21 (17), 2013, pp.19966-19971.","T.Morioka, K, Mori, and M. Saruwatari, \"More than\n100-wavelength-channel picosecond optical pulse generation from\nsingle laser source using supercontinuum in optical fibers\", Electron.\nLett. 29 (10), 1993, pp.862-864.","T.Morioka, H. Takara, S. Kawanishi, O. Kamatani, K. Takiguchi, K.\nUchiyama, M. Saruwatari, H. Takahashi, M. Yamada, T. Kanamori, and\nH. Ono, \"1 T bit/s (100 Gbit/s × 10 channel) OTDM/WDM transmission\nusing a single supercontinuum WDM source\", Electron. Lett. 32 (10),\n1996, pp.906-907.","M. Asobe, K. Naganuma, T. Kaino, T. Kanamori, S. Tomaru, and T.\nKurihara, \"Switching energy limitation in all-optical switching due to\ngroup velocity dispersion of highly nonlinear optical waveguides\", Appl.\nPhys. Lett. 64 (22), 1994, pp.2922-2924.","A. M. Darwish and E. P. Ippen, H. Q. Le, J. P. Donnelly, S. H. Groves,\nand E. A. Swanson, \"Short-pulse wavelength shifting by four wave\nmixing in passive InGaAsP/InP waveguides\", Appl. Phys. Lett. 68 (15),\n1996, pp.2038-2040.","T. L. Koch, T. J. Bridges, E. G. Burkhardt, P. J. Corvini, L. A. Coldren,\nR. A. Linke, W. T. Tsang, R. A. Logan, L. F. Johnson, R. F. Kazarinov,\nR. Yen, and D. P. Wilt, \"1.55-μm InGaAsP distributed feedback vapor\nphase transported buried heterostructure lasers\", Appl. Phys. Lett. 47\n(1), 1985, pp.12-14.\n[10] K. L. Hall, J. Mark, E. P. Ippen, and G. Eisenstein, \"Femtosecond gain\ndynamics in InGaAsP optical amplifiers\", Appl. Phys. Lett. 56 (18),\n1990, pp.1740-1742.\n[11] J. S. Parker, P. R. A. Binetti, A. Bhardwaj, R. S. Guzzon, E. J.\nNorberg, H. Yung Jr., and L. A. Coldren, \"Comparison of comb-line\ngeneration from InGaAsP/InP integrated ring mode-locked lasers\", in\nProc. Conference on Lasers and Electro-Optics (CLEO), Baltimore, MD,\nU.S.A., May 2011, Paper No.CTuV6.\n[12] J. S. Parker, P. R. A. Binetti, H. Yung Jr., and L. A. Coldren, \"Frequency\ntuning in integrated InGaAsP/InP ring mode-locked lasers\", J. Lightwave\nTechnol. 30 (9), 2012, pp.1278-1283.\n[13] G. Agrawal, Nonlinear Fiber Optics, 5th ed., New York: Academic\nPress, 2013.\n[14] W. H. Press, S. A. Teukolsky,W. T. Vetterling, B. P. Flannery, Numerical\nRecipes in C++, 2nd ed. Cambridge: Cambridge University Press, 2002. \n[15] K. Nakatsuhara, T. Mizumoto, R. Munakata, Y. Kigure, and Y. Naito,\n\"Optical bistable devices controlled with pump beam feedback\", in Proc.\nOpto-Electronics and Communications Conference (OECC), Chiba,\nJapan, July 1996, Paper No.18P-13.\n[16] K. Nakatsuhara, T. Mizumoto, S. Hossain, S. H. Jeong ; Y.\nTsukishima, B. J. Ma, and Y. Nakano, \"GaInAsP-InP distributed\nfeedback waveguides for all-optical switching\", IEEE J. Select. Topics\nin Quantum Elect. 6 (1), 2000, pp.143-149.\n[17] E. Kotelnikov, A. Katsnelson, K. Patel, and I. Kudryashov, \"High-power\nsingle-mode InGaAsP/InP laser diodes for pulsed operation\", in Proc.\nSPIE, Novel In-Plane Semiconductor Lasers XI, Vol.8277, 2012,\np.827715 (6 pages)."]}
- Published
- 2014
- Full Text
- View/download PDF
73. Urate-lowering therapy for CKD patients with asymptomatic hyperuricemia without proteinuria elucidated by attribute-based research in the FEATHER Study.
- Author
-
Kataoka H, Mochizuki T, Ohara M, Tsuruta Y, Iwasa N, Yoshida R, Tsuchiya K, Nitta K, Kimura K, and Hosoya T
- Subjects
- Creatinine, Febuxostat therapeutic use, Female, Gout Suppressants therapeutic use, Humans, Male, Proteinuria chemically induced, Proteinuria drug therapy, Treatment Outcome, Uric Acid, Hyperuricemia complications, Hyperuricemia drug therapy, Renal Insufficiency, Chronic complications, Renal Insufficiency, Chronic drug therapy
- Abstract
Attribute-based medicine is essential for patient-centered medicine. To date, the groups of patients with chronic kidney disease (CKD) requiring urate-lowering therapy are clinically unknown. Herein, we evaluated the efficacy of febuxostat using a cross-classification, attribute-based research approach. We performed post hoc analysis of multicenter, randomized, double-blind, placebo-controlled trial data for 395 patients with stage 3 CKD and asymptomatic hyperuricemia. Participants were divided into febuxostat or placebo groups and subcohorts stratified and cross-classified by proteinuria and serum creatinine concentrations. In patients stratified based on proteinuria, the mean eGFR slopes were significantly higher in the febuxostat group than in the placebo group (P = 0.007) in the subcohort without proteinuria. The interaction between febuxostat treatment and presence of proteinuria in terms of eGFR slope was significant (P for interaction = 0.019). When cross-classified by the presence of proteinuria and serum creatinine level, the mean eGFR slopes significantly differed between the febuxostat and placebo groups (P = 0.040) in cross-classified subcohorts without proteinuria and with serum creatinine level ≥ median, but not in the cross-classified subcohorts with proteinuria and serum creatinine level < median. Febuxostat mitigated the decline in kidney function among stage 3 CKD patients with asymptomatic hyperuricemia without proteinuria., (© 2022. The Author(s).)
- Published
- 2022
- Full Text
- View/download PDF
74. I. ANNUAL SUMMARY OF EXPERIMENTAL RESEARCH ACTIVITIES. I-1. PROJECT RESEARCHES
- Author
-
Sakurai, Y.
- Abstract
PR5-1 Establishment of characterization estimation method in BNCT irradiation field using Bonner sphere and ionization chamber (III) /Y. Sakurai et al.(31P5-1) [42], PR5-2 Study on New Type of Neutron Spctrometer for BNCT /A. Uritani et al.(31P5-2) [43], PR5-3 Neutron measurement by using the self-activation of iodine-added plastic scintillators /A. Nohtomi et al.(31P5-4) [44], PR5-4 Characterization of Active Neutron Detector for Boron Neutron Capture Therapy /M. Takada et al.(31P5-5) [45], PR5-5 Study for microdosimetry using silicon-on-insulator microdosimeter in the BNCT irradiation field (III) /Y. Sakurai et al.(31P5-6) [46], PR5-6 Measurement of BNCT beam component fluence with polymer gel detector /K. Tanaka et al.(31P5-7) [47], PR5-7 Development of Neutron Fluence Distribution Measuring Device using Thermoluminescence Slabs /K. Shinsho et al.(31P5-8) [48], PR5-8 The Study for Development and Application of Tissue Equivalent Neutron Dosimeter /M. Oita et al.(31P5-9) [49], PR5-9 Development and evaluation of 3D gel dosimeter for the measurement of dose distribution in BNCT /S. Hayashi et al.(31P5-10) [50], PR5-10 Establishment of beam-quality estimation method in BNCT irradiation field using dual phantom technique (III) /Y. Sakurai et al.(31P5-11) [51], PR5-11 Characteristics test of a Prpmpt Gamma-ray detector using LaBr3(Ce) Scintillator and 8 x 8 Array MPPC for Boron Neutron Capture Therapy /K. Okazaki et al.(31P5-12) [52], PR5-12 Development of Fiber-reading radiation monitoring system with a red/infrared-emitting scintillator at 60Co radiation facilities /S. Kurosawa et al.(31P5-13) [53], PR5-13 Establishment of the Imaging Technology of 478 keV Prompt Gamma-rays of Boron-neutron Capture Reaction and the Measurement of the Intensity of the Neutron Field /T. Mizumoto et al.(31P5-14) [54], PR5-14 Feasibility study of a gel-dosimeter for a quality assurance and a quality control in boron neutron capture therapy /S. Nakamura et al.(31P5-15) [55], PR5-15 Optimization of Bolus Shape for Boron Neutron Capture Therapy Using Epi-thermal Neutron Beam /T. Takata et al.(31P5-16) [56], PR5-16 Development of novel radiochromic gels for assesing 3-dimensional dose distribution in brain /H. Yasuda et al.(31P5-17) [57], PR5-17 Measurement of neutron distributions in the BNCT irradiation field using a GEM detector /S. Uno et al.(31P5-18) [58], PR5-18 Development of Epi-thermal Neutron Flux Intensity Detector for BNCT /I. Murata et al.(31P5-20) [59], PR5-19 Investigation of Thermal Neutron-Induced Soft Errors in Semiconductor Devices /H. Tanaka et al.(31P5-21) [60], In case that corrections are made, an errata will be provided in the following webpage: https://www.rri.kyoto-u.ac.jp/PUB/report/PR/ProgRep2019/ProgRep2019.html
- Published
- 2020
75. I. ANNUAL SUMMARY OF EXPERIMENTAL RESEARCH ACTIVITIES. I-1. PROJECT RESEARCHES
- Author
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Sakurai, Y.
- Abstract
PR7-1 Establishment of Characterization Estimation Method in BNCT Irradiation Field Using Bonner Sphere and Ionization Chamber(II) /Y. Sakurai et al.(30P7-1) [65], PR7-2 Study on New Type of Neutron Spctrometer for BNCT /A. Uritani et al.(30P7-2) [66], PR7-3 Investigation of Deterioration Characteristics of SOF Detector Probe /M. Ishikawa et al.(30P7-3) [67], PR7-4 Beam Profile Measurement at E-3 Irradiation Port by Using the Self-Activation of CsI Plate, A. Nohtomi et al.(30P7-4) [68], PR7-5 Characterization of Active Neutron Detector for Boron Neutron Capture Therapy /M. Takada et al.(30P7-5) [69], PR7-6 Study for Microdosimetry Using Silicon-on-Insulator Microdosimeter in the BNCT Irradiation Field (II) /Y. Sakurai et al.(30P7-6) [70], PR7-7 Measurement of BNCT Beam Component Fluence with Imaging Plate. /K. Tanaka et al.(30P7-7) [71], PR7-8 Development of Neutron Fluence Distribution Measuring Device Using Thermoluminescence Slabs /K. Shinsho et al.(30P7-8) [72], PR7-9 The Study for Development and Application of Tissue Equivalent Neutron Dosimeter /M. Oita et al.(30P7-9) [73], PR7-10 Establishment of Beam-Quality Estimation Method in BNCT Irradiation Field Using Dual Phantom Technique(II) /Y. Sakurai et al.(30P7-11) [74], PR7-11 Development of a Prompt Gamma-Ray Imaging Detector for Boron Neutron Capture Therapy /K. Okazaki et al.(30P7-12) [75], PR7-12 Feasibility Studay on Ultra-High-Dose-Radiation Monitoring System with Bright-Red Scintillator and Fibers /S. Kurosawa et al.(30P7-13) [76], PR7-13 Establishment of the Imaging Technology of 478 keV Prompt Gamma-Rays of Boron-Neutron Capture Reaction and the Measurement of the Intensity of the Neutron Field /T. Mizumoto et al.(30P7-14) [77], PR7-14 Feasibility Study for Establihing Quality Assurance and Quality Control for Radiation Field in Boron Neutron Capture Therapy /S. Nakamura et al.(30P7-15) [78], PR7-15 Patient-Position Monitoring by Using Kinect Sensor for Boron Neutron Capture Therapy /T. Takata et al.(30P7-16) [79], In case that corrections are made, an errata will be provided in the following webpage: https://www.rri.kyoto-u.ac.jp/PUB/report/PR/ProgRep2018/ProgRep2018.html
- Published
- 2019
76. Febuxostat Therapy for Patients With Stage 3 CKD and Asymptomatic Hyperuricemia: A Randomized Trial.
- Author
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Kimura K, Hosoya T, Uchida S, Inaba M, Makino H, Maruyama S, Ito S, Yamamoto T, Tomino Y, Ohno I, Shibagaki Y, Iimuro S, Imai N, Kuwabara M, Hayakawa H, Ohtsu H, and Ohashi Y
- Subjects
- Adult, Age Factors, Aged, Asymptomatic Diseases, Disease Progression, Double-Blind Method, Female, Follow-Up Studies, Humans, Hyperuricemia blood, Japan, Male, Middle Aged, Reference Values, Renal Insufficiency, Chronic diagnosis, Renal Insufficiency, Chronic epidemiology, Risk Assessment, Severity of Illness Index, Sex Factors, Treatment Outcome, Febuxostat administration & dosage, Glomerular Filtration Rate drug effects, Gout Suppressants therapeutic use, Hyperuricemia drug therapy, Renal Insufficiency, Chronic drug therapy
- Abstract
Rationale & Objective: Epidemiologic and clinical studies have suggested that urate-lowering therapy may slow the progression of chronic kidney disease (CKD). However, definitive evidence is lacking., Study Design: Randomized, double-blind, placebo-controlled trial., Setting & Participants: 467 patients with stage 3 CKD and asymptomatic hyperuricemia at 55 medical institutions in Japan., Intervention: Participants were randomly assigned in a 1:1 ratio to receive febuxostat or placebo for 108 weeks., Outcomes: The primary end point was the slope (in mL/min/1.73m
2 per year) of estimated glomerular filtration rate (eGFR). Secondary end points included changes in eGFRs and serum uric acid levels at 24, 48, 72, and 108 weeks of follow-up and the event of doubling of serum creatinine level or initiation of dialysis therapy., Results: Of 443 patients who were randomly assigned, 219 and 222 assigned to febuxostat and placebo, respectively, were included in the analysis. There was no significant difference in mean eGFR slope between the febuxostat (0.23±5.26mL/min/1.73m2 per year) and placebo (-0.47±4.48mL/min/1.73m2 per year) groups (difference, 0.70; 95% CI, -0.21 to 1.62; P=0.1). Subgroup analysis demonstrated a significant benefit from febuxostat in patients without proteinuria (P=0.005) and for whom serum creatinine concentration was lower than the median (P=0.009). The incidence of gouty arthritis was significantly lower (P=0.007) in the febuxostat group (0.91%) than in the placebo group (5.86%). Adverse events specific to febuxostat were not observed., Limitations: GFR was estimated rather than measured, and patients with stages 4 and 5 CKD were excluded., Conclusions: Compared to placebo, febuxostat did not mitigate the decline in kidney function among patients with stage 3 CKD and asymptomatic hyperuricemia., Funding: Funded by Teijin Pharma Limited., Trial Registration: Registered at the UMIN (University Hospital Medical Information Network) Clinical Trials Registry with study number UMIN000008343., (Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.)- Published
- 2018
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77. Interferometric Optical Isolator with Si Guiding Layer Operated in Unidirectional Magnetic Field
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Shingo Matsuzaki, Hideki Yokoi, Hiroyujki Hasegawa, and Atsushi Yumoto
- Subjects
Materials science ,Optical isolator ,Wafer bonding ,business.industry ,Isolator ,Physics::Optics ,Waveguide (optics) ,law.invention ,Magnetic field ,Wavelength ,Interferometry ,Optics ,law ,business ,Layer (electronics) - Abstract
INTRODUCTION In optical communication systems, an optical isolator is indispensable in protecting active photonic devices from unwanted reflected light. An optical isolator with a Si guiding layer is a significant device for silicon photonic integrated circuits. In this paper, the authors report on an interferometric optical isolator with a Si guiding layer which can be operated in unidirectional magnetic field. DEVICE STRUCTURE Figure 1 shows an interferometric optical isolator with a Si guiding layer employing a nonreciprocal phase shift [1]. The nonreciprocal phase shift occurs in transverse-magnetic (TM) modes that travel in magneto-optic waveguides in which magnetization is aligned transverse to the light propagation direction in the film plane. The optical isolator employing the nonreciprocal phase shift is attractive because the device utilizes TM modes only so that there is no need for phase matching. The optical isolator includes an optical interferometer that consists of two coupling devices, a nonreciprocal phase shifter and a reciprocal phase shifter. In Fig. 1, one arm in the optical interferometer has a magnetic garnet cladding layer. When the interferometer has distinct layer structures, the optical isolator can be operated in a unidirectional magnetic field. The optical isolator employing the nonreciprocal phase shift was designed at 1.55 μm. The nonreciprocal phase shifts in the magneto-optic waveguides with a magnetic-garnet/Si/SiO2 structure were calculated. The multimode interference (MMI) coupler and the reciprocal phase shifter were also designed. As a preliminary experiment, deposition of the magnetic garnet crystals were investigated on various substrates. ACKNOWLEDGMENT This work was partially supported by the SIT Research Center for Green Innovation. REFERENCES 1. H. Yokoi, T. Mizumoto and Y. Shoji, Appl. Opt., 42, 6605 (2003). Figure 1
- Published
- 2020
78. Primary cutaneous CD30+ lymphoproliferative disorder in an atopic dermatitis patient on cyclosporine therapy
- Author
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Nakamura, S., Takeda, K., Hashimoto, Y., Mizumoto, T., Ishida-Yamamoto, A., and Iizuka, H.
- Subjects
Atopic dermatitis -- Complications and side effects ,Lymphoproliferative disorders -- Risk factors -- Diagnosis -- Drug therapy -- Patient outcomes -- Case studies ,CT imaging -- Usage -- Health aspects ,Cyclosporine -- Usage -- Health aspects ,Health - Abstract
Byline: S. Nakamura, K. Takeda, Y. Hashimoto, T. Mizumoto, A. Ishida-Yamamoto, H. Iizuka Sir, The risk of lymphoma in atopic dermatitis (AD) is controversial, and both positive and negative correlation [...]
- Published
- 2011
79. Study On Discontinuity Properties Of Phased-Array Ultrasound Transducer Affecting To Sound Pressure Fields Pattern
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Tran Trong Thang, Nguyen Phan Kien, and Trinh Quang Duc
- Subjects
sound pressure pattern ,numerical visualization ,discontinuous sound field ,Phased-array ultrasound transducer - Abstract
The phased-array ultrasound transducer types are utilities for medical ultrasonography as well as optical imaging. However, their discontinuity characteristic limits the applications due to the artifacts contaminated into the reconstructed images. Because of the effects of the ultrasound pressure field pattern to the echo ultrasonic waves as well as the optical modulated signal, the side lobes of the focused ultrasound beam induced by discontinuity of the phased-array ultrasound transducer might the reason of the artifacts. In this paper, a simple method in approach of numerical simulation was used to investigate the limitation of discontinuity of the elements in phased-array ultrasound transducer and their effects to the ultrasound pressure field. Take into account the change of ultrasound pressure field patterns in the conditions of variation of the pitches between elements of the phased-array ultrasound transducer, the appropriated parameters for phased-array ultrasound transducer design were asserted quantitatively., {"references":["W. Leutz, and G. Maret, \"Ultrasonic Modulation of Multiply\nScattered‐Light\", Physica B‐ Condensed Matter, 204(1‐4), 1995,\npp.14‐19.","M. Kobayashi, T. Mizumoto, Y. Shibuya, \"Fluorescence tomography in\nturbid media based on acousto‐optic modulation imaging,\" Applied\nPhysics Letters, 89(18), 2006.","Grinvald A, Lieke E, Frostig RD, Gilbert CD, Wiesel TN, \"Functional\nArchitecture of Cortex revealed by optical imaging of intrinsic signals\",\nNature 324 (6095):1986, pp. 361 - 364","Hao F Zhang, Konstantin Maslov, George Stoica, Lihong V Wang,\n\"Functional photoacoustic microscopy for high-resolution and\nnoninvasive in vivo imaging\", Nature Biotechnology 24, 2006, pp. 848\n– 851.","S. Gunadi, and T. S. Leung, \"Spatial sensitivity of acousto‐optic and\noptical near‐infrared spectroscopy sensing measurements,\" Journal of\nBiomedical Optics, 16(12), 127005‐10, 2011.","Pu Wang, Justin R. Rajian, Ji-Xin Cheng, \"Spectroscopic Imaging of\nDeep Tissue through Photoacoustic Detection of Molecular Vibration\",\nJ.Phys.Chem.Lett, 4, 2013, pp. 2177−2185.","K. Kirk Shung, Gary A. Thieme, \"Ultrasonic Scattering in Biological\nTissues\", CRC Press, 1992.","Q. D. Trinh, Y. Nanbu, T. Suzuki, S. Takahashi, M. Takeda, M.\nKobayashi, \"Basic study on application of the phased-array transducer to\ndetermine fluorescence in turbid media based-on acousto-optic effects.\"\nInternational Conference on Laser Applications in Life Sciences (LALS\n2008).","Q. D. Trinh, Y. Nanbu, T. Suzuki, S. Takahashi, M. Takeda, M.\nKobayashi, \"Fluorescence tomography based-on acousto-optic\nmodulations with phased-array ultrasound transducer.\" BiOS Part of\nSPIE Photonic West, paper No. 7177-57 (San Jose, USA, 2009).\n[10] T.Q.Duc, S.Kaneta, M.Masaki, \"Development of Ultrasonic Modulation\nProbe for Fluorescence Tomography Based on Acousto-Optic Effect.\"\nInternational Journal Optic, Vol. 2011, 818302, pp. 1-6.\n[11] T. Q. Duc, S. Kaneta, M. Kobayashi, \"Study on the Mechanism of\nUltrasonic Fluorescence Modulation in Light Scattering Medium Based\non Diffusion Approximation with Varying Refractive Index.\" Optical\nReview Vol. 19, No. 3, 2012, pp. 1-8.\n[12] André LAMARRE, \"Dynamic Focusing of Phased Arrays for\nNondestructive Testing: Characterization and Application\", NDT.net,\nVol. 4 No. 9, 1999."]}
- Published
- 2014
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80. Hemophagocytic Syndrome in Five Patients with Epstein-Barr Virus Negative B-Cell Lymphoma
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Lymphomas -- Physiological aspects ,Health ,Physiological aspects - Abstract
Ohno, T.; Miyake, N.; Hada, S.; Hirose, Y.; Imura, A.; Hori, T.; Uchiyama, T.; Saiga, T.; Mizumoto, T.; Furukawa, H. 'Hemophagocytic Syndrome in Five Patients with Epstein-Barr Virus Negative B-Cell [...]
- Published
- 1998
81. Colorectal Carcinoma (Prognostics) 'Predictive Value of Vascular Endothelial Growth Factor (VEGF) in Metastasis and Prognosis of Human Colorectal Cancer.' British Journal of Cancer, November 1998;78(10):1379-1384
- Subjects
Health - Abstract
Ishigami, S.I.; Arii, S.; Furutani, M.; Niwano, M.; Harada, T.; Mizumoto, M.; Mori, A.; Onodera, H.; Imamura, M. According to the authors' abstract of an article published in British Journal [...]
- Published
- 1998
82. Ultracompact polarization converter with a dual subwavelength trench built in a silicon-on-insulator waveguide
- Author
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Villafranca Velasco, Aitor, Calvo Padilla, María Luisa, Cheben, Pavel, Ortega Moñux, Alejandro, Alonso Ramos, Carlos Alberto, Molina fernández, Íñigo, Lapointe, Jean, Vachon, Martin, Janz, Siegfried, Xu, Dan-Xia, Villafranca Velasco, Aitor, Calvo Padilla, María Luisa, Cheben, Pavel, Ortega Moñux, Alejandro, Alonso Ramos, Carlos Alberto, Molina fernández, Íñigo, Lapointe, Jean, Vachon, Martin, Janz, Siegfried, and Xu, Dan-Xia
- Abstract
© 2012 Optical Society of America. Financial support from the Spanish Ministry of Science and Innovation (MICINN) is acknowledged under grants TEC2008-04105 and TEC2009-10152., The design and fabrication of an ultracompact silicon-on-insulator polarization converter is reported. The polarization conversion with an extinction ratio of 16 dB is achieved for a conversion length of only 10 mu m. Polarization rotation is achieved by inducing a vertical asymmetry by forming in the waveguide core two subwavelength trenches of different depths. By taking advantage of the calibrated reactive ion etch lag, the two depths are implemented using a single mask and etching process. The measured converter loss is -0.7 dB and the 3 dB bandwidth is 26 nm., Ministerio de Ciencia e Innovación (MICINN), España, Depto. de Óptica, Fac. de Ciencias Físicas, TRUE, pub
- Published
- 2023
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