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351. Isolation of the porcine heparin tetrasaccharides with glucuronate 2-O-sulfate. Heparinase cleaves glucuronate 2-O-sulfate-containing disaccharides in highly sulfated blocks in heparin.

Author

Yamada, S, Murakami, T, Tsuda, H, Yoshida, K, and Sugahara, K

Abstract

Eleven tetrasaccharides were isolated from the repeating disaccharide region of porcine intestinal heparin after strong digestion with Flavobacterium heparinase. Their structures were determined by composition analysis, enzymatic analysis, and 1H NMR spectroscopy. Nine of them have the common tetrasaccharide backbone, delta HexA alpha 1-4GlcN alpha 1-4IdoA alpha 1-4GlcN, where delta HexA and IdoA represent 4,5-unsaturated hexuronic acid and L-iduronic acid, respectively, and their structural variations are based upon the positions of sulfate groups. The nine compounds include one hexasulfated, three pentasulfated and five tetrasulfated compounds, and four of them have not been isolated previously as discrete structures. The other two of the 11 tetrasaccharides have the following hitherto unreported structures with novel glucuronate 2-O-sulfate at the internal position: delta HexA(2-sulfate) alpha 1- 4GlcN(N,6-disulfate) alpha 1-4GlcA(2-sulfate) beta 1-4GlcN(N-sulfate) and delta HexA(2-sulfate) alpha 1-4GlcN(N,6-disulfate) alpha 1-4GlcA(2-sulfate) beta 1-4GlcN(N,6-disulfate). Thus, 2-O-sulfated glucuronate in the highly sulfated tetrasaccharide structures typical of heparin has been demonstrated. The former and the latter tetrasaccharides account for 0.31 and 0.32% (w/w) of the starting heparin, respectively. Their yield, however, is an underestimation, since these tetrasaccharide structures in longer sequences will be degraded by heparinase. Although the latter tetrasaccharide described above was unexpectedly cleaved by heparinase into two disaccharide units, the former was not degraded by the enzyme most likely due to the lack of the 6-O-sulfate group on the GlcN residue at the reducing terminus. The results indicate its capability of catalyzing both anti and syn elimination, a property shared by heparitinases I and II and chondroitinase ABC. Both tetrasaccharides were degraded into disaccharides by heparitinase II. Therefore, it is necessary to reevaluate the disaccharide composition of heparin/heparan sulfate or oligosaccharide structures, which were previously determined after heparinase or heparitinase II digestion. It is no longer possible to conclude that the 2-O-sulfated unsaturated uronic acid residues obtained from heparin/heparan sulfate by lyase digestions are always derived from iduronate 2-O-sulfate residues in the original polymer. It is quite possible that the novel glucuronate 2-O-sulfate structure in the highly sulfated region of heparin is involved in some of the biological activities of heparin.

Published
1995

352. Structural studies on the hexasaccharide alditols isolated from the carbohydrate-protein linkage region of dermatan sulfate proteoglycans of bovine aorta. Demonstration of iduronic acid-containing components.

Author

Sugahara, K, Ohkita, Y, Shibata, Y, Yoshida, K, and Ikegami, A

Abstract

Five major hexasaccharide alditols were isolated from the carbohydrate-protein linkage region of bovine aorta dermatan sulfate peptidoglycans after reductive beta-elimination and subsequent chondroitinase ABC digestion. These molecules account for at least 55.3% of the total linkage region. Their structures were analyzed by enzymatic digestion in conjunction with high performance liquid chromatography, electrospray ionization mass spectrometry, and 500-MHz one- and two-dimensional 1H NMR spectroscopy. Three of these compounds have the conventional hexasaccharide core; delta HexA alpha 1-3Gal-NAc beta 1-4GlcA beta 1-3Gal beta 1-3Gal beta 1-4Xyl-ol. One is nonsulfated, and the other two are monosulfated on C6 or C4 of the GalNAc residue. They represent at least 6.3, 5.2, and 28.8% of the total linkage region, respectively. The other two compounds have the following hitherto unreported hexasaccharide core with an internal iduronic acid residue in common; delta HexA alpha 1-3GalNAc beta 1-4IdoA alpha 1-3Gal beta 1-3Gal beta 1-4Xyl-ol. One is monosulfated on C4 of the GalNAc, and the other is disulfated on C4 of the GalNAc and of the galactose residue substituted by the iduronic acid residue. These two compounds account for 35% of the five isolated hexasaccharide alditols and at least 4.3 and 10.7% of the total linkage region, respectively. The latter two structures form a striking contrast to the currently accepted conception that heparin, heparan sulfate, and chondroitin/dermatan sulfate share the common linkage tetrasaccharide core GlcA beta 1-3Gal beta 1-3Gal beta 1-4Xyl. The biological significance of the isolated structures is discussed in relation to the biological functions and the biosynthetic mechanisms of dermatan sulfate.

Published
1995

354. Biosynthesis of hyaluronic acid by Streptococcus.

Author

Sugahara, K, Schwartz, N B, and Dorfman, A

Abstract

Synthesis of hyaluronic acid was investigated in a cell-free system derived from a strain of Group A streptococci. Preparative procedures were improved so that an enzyme system 70 times more active than that previously reported was obtained. The hyaluronic acid synthesized could be separated into trichloroacetic acid-soluble and -insoluble fractions. On the basis of pulse-chase experiments, it was shown that the trichloroacetic acid-insoluble fraction is a precursor of the soluble fraction. The release of the trichloroacetic acid-insoluble hyaluronic acid is specifically blocked with p-chloromercuribenzoate, without inhibition of chain elongation. The addition of butanol to trichloroacetic acid resulted in solubilization of all of the hyaluronic acid. No detectable difference in molecular size was observed between the two hyaluronic acid fractions, both of which were estimated to be more than one million daltons in size. Testicular hyaluronidase digestion of either one of the two types of hyaluronic acid yielded no high molecular weight fragments, indicating that hyaluronic acid is not bound covalently to protein. However, following incubation of enzyme assay mixtures with UDP-[14C]GlcUA, even in the absence of UDP-GlcNAc, radioactive high molecular weight hyaluronic acid was obtained which suggests that the enzyme system elongates rather than initiates hyaluronic acid chains. Tunicamycin did not inhibit hyaluronic acid synthesis, indicating lack of participation of an intermediate of pyrophosphorylpolyisoprenol type. The results obtained are consistent with the hypothesis that chain elongation of hyaluronic acid proceeds by alternate addition of monosaccharides from UDP-sugars by a membrane-bound synthesizing system followed by release of completed hyaluronic acid chains.

Published
1979
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355. Structural studies on sulfated glycopeptides from the carbohydrate-protein linkage region of chondroitin 4-sulfate proteoglycans of swarm rat chondrosarcoma. Demonstration of the structure Gal(4-O-sulfate)β1-3Galβ1-4Xylβ1-O-Ser

Author

Vliegenthart, J.F.G., Sugahara, K., Yamashina, I., Waard, P. de, and Halbeek, H. van

Subjects
Scheikunde
Abstract

Nonsulfated, monosulfated, and disulfated glycopeptides containing the entire carbohydrate sequence of the glycosaminoglycan-specific linkage region were isolated after exhaustive enzymatic digestions of Swarm rat chondrosarcoma proteoglycans with chondroitinase ABC, papain, and Pronase. Their structures were examined by 500 MHz 1H NMR spectroscopy. The nonsulfated compound has the following structure with trace amounts of a few additional amino acids: delta 4,5-GlcAβ1-3GalNAcβ1- 4GlcAβ 1-3Galβ 1-3Galβ 1-4Xylβ 1-O-Ser. The monosulfated compound has an ester sulfate on C-4 of the GalNAc residue and the disulfated compound has an additional hitherto unrecognized ester sulfate on C-4 of the second galactose residue which is remote from the innermost xylose. This new structure was confirmed by two- dimensional homonuclear Hartmann-Hahn spectroscopy. The molar ratio of the isolated nonsulfated, monosulfated, and disulfated compounds was 53:37:10 based on the serine contents. Biological significance of the newly found sulfated linkage structure is discussed.

Published
1988

356. Lateral impurity transport in silicon films on insulators during laser recrystallization.

Author

Sugahara, K., Nishimura, T., Akasaka, Y., and Nakata, H.

Subjects
*SILICON-on-insulator technology, *IMPURITY distribution in semiconductors
Abstract

The lateral transport of dopants in silicon films on insulators during laser recrystallization is investigated. The dopants implanted locally in silicon films on insulators are found to be transported in the forward direction of the laser scan as well as the backward direction. Both transport lengths from the originally implanted region are measured as a function of the laser scan velocity. The transport mechanism is explained by taking into account a liquid phase diffusion and a segregation of impurities depending on the crystallization speed. The diffusion coefficients of (1.2±0.2)×10-4 and (1.3±0.4)×10-4 cm2/s for arsenic and boron, respectively, in molten silicon are obtained. [ABSTRACT FROM AUTHOR]

Published
1986
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359. Spontaneous Neuroma of the Bile Duct: A Case Report.

Author

Sugahara, K., Yamamoto., M., lizuka, H., Yoshioka, M., and Miura, K.

Subjects
NEUROMAS, BILE duct diseases, ABDOMINAL surgery, GALLSTONES, LIVER function tests
Abstract

We report on a 65-year-old man with a stenosis of the bile duct which was caused by spontaneous neuroma, with no history of laparotomy. Although he had a gallstone and slightly abnormal parameters on liver function tests, he had no known history of abdominal pain or jaundice. This is a very rare case of a benign stenosis of the common bile duct. [ABSTRACT FROM AUTHOR]

Published
1985

365. The spinal GDNF level is increased after transient spinal cord ischemia in the rat

Author

Joho Tokumine, Sugahara K, Kakinohana O, and Marsala M

Subjects
Male, Rats, Sprague-Dawley, Spinal Cord, Ischemia, Animals, Enzyme-Linked Immunosorbent Assay, Glial Cell Line-Derived Neurotrophic Factor, Nerve Growth Factors, Immunohistochemistry, Rats
Abstract

Glial cell line-derived neurotrophic factor (GDNF) is known as the most potent neurotrophic factor against injury. We have characterized spinal GDNF changes after ischemia to clarify its possible physiological role against ischemic damage. Spinal ischemia in the rat was produced by cross-clamping of the thoracic aorta together with systemic hypotension. The spinal tissue GDNF level was measured by enzyme-linked immunoabsorbent assay (ELISA) and the localization of GDNF in the tissue was examined by immunohistochemistry. GDNF was increased reaching two peaks after ischemia. The first peak was at 2 hrs after onset of recirculation derived from alpha motor neurons. The second GDNF peak was at 72 hrs provided by astrocytes. These data suggest a necessity of GDNF to increase to protect against ischemic damage, and that activated astrocytes may have an important role in maintaining the GDNF level.

367. Lanthionine Ketimine and S-(2-aminoethyl)-L-cysteine Ketimine Induce the Tyrosyl Phosphorylation of 45 kDa Protein in Parallel with its Stimulation of Superoxide Generation in Human Neutrophils

Author

Zhang, J., Sugahara, K., Hashimoto, K., Sagara, Y., Mario FONTANA, Duprè, S., and Kodama, H.

Subjects
N-Formylmethionine Leucyl-Phenylalanine, Amino Acids, Sulfur, Neutrophils, Superoxides, Humans, Tyrosine, NADH Dehydrogenase, Blood Proteins, Enzyme Inhibitors, In Vitro Techniques, Phosphorylation, Genistein, Stimulation, Chemical
Abstract

Human peripheral blood polymorphonuclear leukocytes were preincubated with lanthionine, S-(2-aminoethyl)-L-cysteine, and some of their derivatives found in normal human urine and bovine brain. Among these compounds, lanthionine ketimine and to a lesser extent S-(2-aminoethyl)- L-cysteine ketimine enhanced the N-formyl-methionyl-leucyl-phenylalanine-induced superoxide generation. These ketimines induced tyrosyl phosphorylation of 45 kDa protein of cells. The tyrosyl phosphorylation was markedly increased with time, and the phosphorylation process was dependent on the concentration of both ketimines. However, lanthionine, 1,4-thiomorpholine-3,5-dicarboxylic acid, S-(2-aminoethyl)-L-cysteine and 1,4-thiomorpholine-3-carboxylic acid were without effect both on superoxide generation and on tyrosyl phosphorylation of 45 kDa protein. Lanthionine ketimine and S-(2-aminoethyl)-L-cysteine ketimine also enhanced superoxide generation induced by opsonized zymosan but not the one induced by arachidonic acid and phorbol 12-myristate 13-acetate. Ketimine-primed superoxide generation and tyrosyl phoshorylation of 45 kDa protein were inhibited by genistein, an inhibitor of protein tyrosine kinase, but not by 1-(5-isoquinoline sulfonyl)-2- methylpiperazine, an inhibitor of protein kinase C.

380. General Lectures-(II)

Author

Toriie, S., primary, Nakajima, M., additional, Kohli, Y., additional, Takebayashi, M., additional, Misaki, F., additional, Kobayashi, A., additional, Hashimoto, Y., additional, Mitsuyoshi, Y., additional, Ida, K., additional, Kawai, K., additional, Fujita, R., additional, Kumura, F., additional, Takahashi, M., additional, Ohsawa, H., additional, Hasegawa, Y., additional, Kidokoro, T., additional, Jojima, Y., additional, Miyoshi, H., additional, Okumura, Y., additional, Yokouchi, A., additional, Asano, H., additional, Uehara, A., additional, Oka, S., additional, Saito, H., additional, Yaginuma, M., additional, Yamamoto, T., additional, Asano, A., additional, Nakamura, M., additional, Okada, Y., additional, Tomioka, T., additional, Tamesue, N., additional, Ikeda, S., additional, Kunisaki, T., additional, Emura, T., additional, Yasumoto, M., additional, Someya, N., additional, Goto, A., additional, Morokuma, K., additional, Sakamoto, H., additional, Kasaki, Y., additional, Imamura, K., additional, Amano, I., additional, Iwanaga, K., additional, Okugawa, N., additional, Ninomiya, K., additional, Yoshida, S., additional, Okabe, N., additional, Shimogawa, Y., additional, Akasaka, Y., additional, Shimamoto, K., additional, Toriie, S., additional, Tada, M., additional, Sugawara, K., additional, Chikayasu, I., additional, Takeda, H., additional, Shibue, T., additional, Yamaguchi, A., additional, Osame, T., additional, Shimada, K., additional, Hori, M., additional, Irisa, T., additional, Miura, Y., additional, Hanamure, B., additional, Chuman, Y., additional, Sato, H., additional, Kizu, M., additional, Kasugai, T., additional, Kuno, N., additional, Aoki, I., additional, Nitta, Y., additional, Machii, A., additional, Murakami, Y., additional, Aiso, Y., additional, Kitahara, N., additional, Yoshizawa, Y., additional, Hishinuma, Y., additional, Nao, Y., additional, Ishiyama, K., additional, Watanabe, M., additional, Kimura, T., additional, Hara, T., additional, Sakaue, S., additional, Shinoda, T., additional, Ito, R., additional, Hayashi, K., additional, Sugie, H., additional, Sekizawa, H., additional, Nakamura, S., additional, Kondo, J., additional, Tanaka, E., additional, Taniguchi, T., additional, Kanayama, M., additional, Koizumi, S., additional, Watabiki, S., additional, Tamura, K., additional, Arai, T., additional, Saito, T., additional, Tojo, S., additional, Furuya, M., additional, Hanaue, H., additional, Ogoshi, K., additional, Murohisa, B., additional, Uchimura, M., additional, Ishigaki, J., additional, Waki, S., additional, Nakafuji, H., additional, Iida, F., additional, Aratake, K., additional, Nakano, T., additional, Ono, N., additional, Hara, I., additional, Sassa, T., additional, Takahashi, T., additional, Inoue, J., additional, Maruyama, Y., additional, Mori, Y., additional, Kawamura, T., additional, Imai, F., additional, Yorita, S., additional, Saegusa, M., additional, Ishihara, F., additional, Asukata, I., additional, Matsuda, M., additional, Wakabayashi, K., additional, Mitani, S., additional, Sugahara, K., additional, Ishikawa, K., additional, Nakayoshi, A., additional, Nakamoto, M., additional, Kono, A., additional, Oda, T., additional, Sato, Y., additional, Nagao, F., additional, Nagano, M., additional, Furusawa, T., additional, Nakama, T., additional, Itoh, H., additional, Nishimura, M., additional, Tsutsumi, K., additional, Yoshida, K., additional, Ito, H., additional, Yoshimura, M., additional, Yoshioka, K., additional, Shimizu, T., additional, Kuroda, C., additional, Uchida, H., additional, Ishida, O., additional, Inoue, T., additional, Hasegawa, S., additional, Mitsusada, K., additional, Kajiyama, Y., additional, Matsuzawa, Y., additional, Yokota, K., additional, Hayashida, Y., additional, Ikegudhi, S., additional, Shida, S., additional, Tsurumi, K., additional, Ito, K., additional, Kamiya, K., additional, Takada, H., additional, Ueno, S., additional, Onda, M., additional, Kojima, G., additional, Shoji, E., additional, Miyaji, M., additional, Goto, K., additional, Yazaki, Y., additional, Ito, M., additional, Kozuka, M., additional, Tanabe, A., additional, Murate, H., additional, Takeuchi, T., additional, Koshikawa, M., additional, Kato, N., additional, Maeda, K., additional, Tsuru, T., additional, Ooyama, I., additional, Kukimoto, H., additional, Nakashima, Y., additional, Katsuki, T., additional, Ueda, N., additional, Kanno, T., additional, Noda, A., additional, Toda, Y., additional, Hayakawa, T., additional, Nakajima, S., additional, Morishita, R., additional, Furukawa, K., additional, Ikeda, F., additional, Fujii, M., additional, Wakisaka, G., additional, Matasumoto, Y., additional, Ono, H., additional, Hirose, S., additional, Kobayashi, K., additional, Sawabu, N., additional, Takeuchi, J., additional, Kajikawa, K., additional, Takada, A., additional, Hirai, Y., additional, Ohki, I., additional, Sato, K., additional, Tasaka, S., additional, Sato, A., additional, Aono, G., additional, Takezoe, K., additional, Ohara, T., additional, Soma, S., additional, Ukawa, S., additional, Yamaguchi, S., additional, Shirahama, T., additional, Sugiyama, K., additional, Koyama, H., additional, Haga, M., additional, Arikawa, H., additional, Toyokawa, H., additional, Sato, R., additional, Ueno, Y., additional, Karasawa, Y., additional, Onuma, H., additional, Suzuki, H., additional, Murakami, T., additional, Yasui, A., additional, Ichinose, Y., additional, Hirase, Y., additional, Okazaki, T., additional, Takai, T., additional, Watanabe, K., additional, Kato, M., additional, Yamada, M., additional, Tsuji, T., additional, Kunito, Y., additional, Kobayashi, S., additional, Udo, K., additional, Iriyama, K., additional, Sugiura, Y., additional, Takahashi, Y., additional, Kawamura, O., additional, Ando, S., additional, Tsuji, K., additional, Yukawa, Y., additional, Saito, N., additional, Miyazawa, M., additional, Imai, K., additional, Tabayashi, T., additional, Umehara, S., additional, Watanabe, Y., additional, Murai, S., additional, Nukaga, A., additional, Ishimatsu, N., additional, Sotoyama, S., additional, Abe, M., additional, Hirai, K., additional, Aoki, T., additional, Aoki, Y., additional, Taniguchi, K., additional, Wada, N., additional, Tabuse, K., additional, Yanagi, I., additional, Tsuhada, K., additional, Katsumi, M., additional, Nakamura, K., additional, Takemoto, K., additional, Yamaura, Y., additional, Karibe, N., additional, Yamada, G., additional, Ichikawa, H., additional, Ogiwara, M., additional, Matsushita, M., additional, Kobayashi, I., additional, Kusano, M., additional, Yasuna, O., additional, Hayashi, S., additional, Yoshizumi, M., additional, Kojima, Y., additional, Matsubayashi, K., additional, Nishimura, R., additional, Koga, M., additional, Tachibana, M., additional, Kurata, M., additional, Suto, H., additional, Ichinose, I., additional, Ishizuka, K., additional, Shimoda, M., additional, Onai, M., additional, Akiyama, T., additional, Sekiguchi, T., additional, Matsuyoshi, M., additional, Yonezawa, N., additional, Kasamatsu, M., additional, Yokota, Y., additional, Toyoda, T., additional, Uchimoto, I., additional, Kanamoto, M., additional, Fukai, Y., additional, Katoh, M., additional, Nakamura, I., additional, Tamura, M., additional, Nishio, M., additional, Mukaide, Y., additional, Kuzumoto, Y., additional, Ota, K., additional, Yoshida, T., additional, Sakamoto, A., additional, Kaneko, S., additional, Yanagida, M., additional, Kishimoto, S., additional, Miyaji, K., additional, Shiraki, Y., additional, Inoue, K., additional, Tamada, T., additional, Usui, T., additional, Ohtsuka, K., additional, Yamada, S., additional, Fujishima, S., additional, Tamiya, A., additional, Saji, K., additional, Ueda, A., additional, Yasutake, K., additional, Irie, K., additional, Ijiri, Y., additional, Nishijima, H., additional, Ogino, K., additional, Okuno, T., additional, Date, H., additional, Yao, T., additional, Koga, Y., additional, Fuyuno, S., additional, Okabe, H., additional, Mitsui, H., additional, Tamechika, Y., additional, Masuda, N., additional, Fujiwara, T., additional, Sakimura, M., additional, Takamura, Y., additional, Kono, T., additional, Kurihara, M., additional, Sumida, M., additional, Izumi, T., additional, Haraikawa, M., additional, Hayakawa, H., additional, Shirakabe, H., additional, Ushio, K., additional, Okamoto, M., additional, Noguchi, M., additional, Kinoshita, A., additional, Yamada, T., additional, Shimotori, K., additional, Kudo, T., additional, Mukaida, I., additional, Ishikawa, H., additional, Shirane, T., additional, Kano, A., additional, Suzuki, T., additional, Tanaka, M., additional, Iwanaga, T., additional, Taniguchi, H., additional, Inawashiro, M., additional, Endo, N., additional, Suzuki, Sh., additional, Maki, T., additional, Hayakawa, K., additional, Ikezawa, H., additional, Jao, C. C., additional, Yamada, K., additional, Maruyama, M., additional, Nagasako, K., additional, Oi, I., additional, Kozu, T., additional, Yamashita, K., additional, Yokoyama, I., additional, Endo, M., additional, Takemoto, T., additional, Nakayama, K., additional, Hayakawa, R., additional, Ishiguro, M., additional, Nakano, H., additional, Nakazawa, S., additional, Tsuboi, Y., additional, Yamase, H., additional, Yamashita, T., additional, Fujita, T., additional, Ishikawa, Y., additional, Ito, N., additional, Mitsuno, T., additional, Kanazawa, K., additional, Yamashiro, M., additional, Kubo, T., additional, Iizuka, H., additional, Watanabe, T., additional, Sanada, M., additional, Satoh, H., additional, Shimada, H., additional, Kusama, S., additional, Ikeda, K., additional, Naramoto, J., additional, Okazaki, Y., additional, Kawamura, S., additional, Fujimoto, S., additional, Urayama, S., additional, Matsuura, H., additional, Sekitani, T., additional, Sasayama, T., additional, Nakagawa, K., additional, Toyama, K., additional, Nakagawa, S., additional, Takada, T., additional, Kusaka, K., additional, Takaba, S., additional, Satomura, A., additional, Kawakami, Y., additional, Koike, T., additional, Joh, S., additional, Kobayagawa, K., additional, Hashimoto, T., additional, Uemura, F., additional, Fukui, O., additional, Takasato, Y., additional, Shirakawa, K., additional, Hisamatsu, M., additional, Ashizawa, S., additional, Sakurane, Y., additional, Miyamura, K., additional, Sasaki, H., additional, Ura, S., additional, Emoto, M., additional, Tatsumi, Y., additional, Totsuka, Y., additional, Chiba, N., additional, Ozeki, M., additional, Nakazawa, M., additional, Takamura, S., additional, Sawano, Y., additional, Sugita, T., additional, Funabiki, T., additional, Watanabe, S., additional, Moriya, T., additional, Tomita, N., additional, Nishida, K., additional, Todo, A., additional, Miyake, T., additional, Suzaki, Y., additional, Yamamoto, Y., additional, Ariyoshi, J., additional, Hajiro, K., additional, Oishi, M., additional, Yanagihara, K., additional, Nakamura, A., additional, Kuramata, H., additional, Soeda, S., additional, Kondo, N., additional, Akashi, M., additional, Hemmi, T., additional, Kadono, H., additional, Ito, T., additional, Tsuchiya, R., additional, Ikeda, Y., additional, Futatsuki, K., additional, Nomoto, S., additional, Kino, I., additional, Arai, M., additional, Shimazu, H., additional, Kobori, O., additional, Hiroshima, Y., additional, Matsusaka, Y., additional, Katase, K., additional, Sakuma, Y., additional, Murata, N., additional, Komura, K., additional, Ando, H., additional, Ohara, K., additional, Hayashi, A., additional, Suzuki, M., additional, Watanuki, T., additional, Asano, T., additional, Koide, N., additional, Shiobara, M., additional, Matsuo, N., additional, Segawa, K., additional, Matsumoto, K., additional, Machida, K., additional, Koizumi, Y., additional, Hoshi, Y., additional, Oi, M., additional, Seki, H., additional, Matsumura, M., additional, Kimura, M., additional, Ishikawa, I., additional, Kishi, S., additional, Kondo, Y., additional, Uchida, Y., additional, Harada, H., additional, Mandai, M., additional, Kikuchi, T., additional, Mishima, K., additional, Yamagata, Y., additional, Suyama, T., additional, Kawagoe, K., additional, Inagawa, T., additional, Sugiya, T., additional, Kai, T., additional, Miyoshi, A., additional, Fukumoto, S., additional, Kojo, H., additional, Turuhara, I., additional, Miyoshi, Y., additional, Okamoto, K., additional, Inata, H., additional, Okamoto, H., additional, Sakurai, S., additional, Sugiyama, M., additional, Miura, K., additional, Kurihara, T., additional, Sakumoto, K., additional, Okita, E., additional, Tanaka, H., additional, Ishihara, K., additional, Okawa, M., additional, Nishizaki, N., additional, Saito, K., additional, Aoyagi, K., additional, Hamaguchi, E., additional, Kitamura, T., additional, Matsuo, Y., additional, Seki, A., additional, Mori, H., additional, Ishikawa, T., additional, Nakajima, T., additional, Shimomura, T., additional, Sengoku, K., additional, Uchiya, Y., additional, Yabana, T., additional, Konta, M., additional, Kamijo, K., additional, Yachi, A., additional, Okuse, S., additional, Ohara, H., additional, Wada, T., additional, Furuta, K., additional, Nishii, M., additional, Yamawaki, T., additional, Nishii, K., additional, Umeda, K., additional, Yoshida, H., additional, Okabayashi, T., additional, Kato, Y., additional, Yatsuji, Y., additional, Suzuki, Y., additional, Nomura, K., additional, Kamisaka, K., additional, Motoki, T., additional, Kamii, K., additional, Kameda, H., additional, Imamura, H., additional, Uchiya, T., additional, Ishizawa, M., additional, Nishizaki, H., additional, Orimo, H., additional, Yoshida, A., additional, Itoh, Z., additional, Honda, R., additional, Takeuchi, S., additional, Fukushima, T., additional, Suda, T., additional, Shinonaga, M., additional, Ishiguro, N., additional, Fujisawa, S., additional, Nishiyama, K., additional, and Ohkubo, T., additional

Published
1973
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390. Symposium (III): Problems around the primary liver cancer especially viewed from the standpoint of pathophysiology

Author

Kuratomi, S., primary, Sakamoto, K., additional, Takashima, T., additional, Yamamoto, I., additional, Sugahara, K., additional, Kashii, A., additional, Endo, Y., additional, Kanai, K., additional, Okazaki, N., additional, Araki, E., additional, Shibasaki, K., additional, Ichida, F., additional, Shimogawa, Y., additional, Kubo, Y., additional, Ozawa, K., additional, and Takasan, H., additional

Published
1974
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