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Both geometrical isomers (E and Z) of an aminotamoxifen (2) have been prepared as precursors of the corresponding E and Z iodotamoxifens (1). The ability of E and Z-1 and 2 to compete with [3H]estradiol for estrogen receptors in rat uterine cytosol was measured relative to Z-tamoxifen and estradiol. The four tamoxifen derivatives showed affinities ranging from 50% to 1600% of that of tamoxifen. Under the same conditions, tamoxifen's relative binding affinity was 0.2% of that of estradiol. Preparative routes to the radioiodo-tamoxifens, [131I]-E and Z-1, were also developed and provided approximately 100 MBq of 'no carrier added' material in 40-60% radiochemical yield. Study of the biodistribution of these radioligands in tumor-bearing mice demonstrated significant radioactivity in the tumors and in the uterus. For [131I]-E-1, target to background ratios reached 28 for uterus/blood and 10 for tumor/blood; corresponding optimum ratios for [131I]-Z-1 were 10 and 5. A washout study using estradiol indicated selective uptake in the uterus of Swiss white mice. However, tumor uptake and image contrast in humans following intravenous administration of either [131I]-E or Z-1 were insufficient to allow diagnostic use of the radioiodotamoxifens.

During a 6-week period, the effects of sensory integrative activities on a group of seven chronic nonparanoid schizophrenic adults were compared to the effects of sedentary activities in a control group of seven similar subjects. The effects of each therapeutic approach were evaluated by measuring the patients' performance in several areas using the Nurses Observation Scale of Inpatient Evaluation-30 (NOSIE-30), The Object Manipulation Speed Test, a gait analysis, and grip strength. The results indicated general improvement in the experimental group. Behaviors measured by the NOSIE-30 showed the most significant improvements. The control group showed isolated improvements in grooming (measured by the NOSIE-30) and in right-hand use (measured by The Object Manipulation Speed Test). These findings suggest that 6 weeks of sensory integrative activities can improve the overall functioning of chronic nonparanoid schizophrenic patients, facilitate their adaptive responses, and enable them to participate more fully in other areas of therapeutic intervention.

Practice models which depict the interactions of Certified Occupational Therapy Assistants and Registered Occupational Therapists are described. These models portray career ladder development for the Certified Occupational Therapy Assistant. Job enrichment for the assistant facilitates the provision of qualitative and cost effective occupational therapy sessions.

Research data suggest that 24% of the 25- to 34-year-old age group are college graduates who are prime candidates for returning to the university campus. As a professional field in which the enrollment of traditional-age students might decline, occupational therapy may need to find ways to attract older students. Thus, there is a need to examine whether occupational therapy curricula are designed to accommodate older students.