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Central post-stroke pain (CPSP), a neuropathic pain syndrome occurring after a cerebrovascular accident, is characterized by pain or paraesthesia in the part of the body dominated by the area of the brain where blood vessels are injured. CPSP patients are often accompanied by anxiety, depression and other emotional disorders, which have a serious negative impact on patients' quality of life. However, the pathogenesis of CPSP has not been fully elucidated, the clinical diagnosis rate is not high, and the commonly used treatment methods are not effective. This article reviews the clinical features, epidemiology, pathogenesis and treatment of CPSP in order to provide reference for the elucidation of CPSP mechanism and effective treatment.

The present study was designed to test the hypothesis that a small dose of ketanserin, which enhances baroreflex activity, prevents the early lesions of atherosclerosis. In experiment 1, baroreflex sensitivity (BRS) was measured in 31 spontaneously hypertensive rats (SHRs) in a conscious state using a computerized blood pressure monitoring system. Four weeks later, the rats were administered vitamin [D.sub.3] and fed a high-cholesterol diet for 8 weeks to induce atherosclerosis. Then their hearts and aortae were removed for pathological examination. A negative correlation was found between BRS and the scores of coronary (r = -0.460, P < 0.01) and aortic atherosclerosis (r = -0.448, P < 0.05) in SHR. In experiment 2, SHRs were divided into 3 groups (n = 10 in each group) and received a dose of ketanserin of 0.3, 1.0, and 3.0 mg/kg (i.g.), respectively. At the smallest dose (0.3 mg/kg), ketanserin did not lower blood pressure but enhanced BRS. In experiment 3, SHRs were administered vitamin [D.sub.3], fed a high-cholesterol diet, and simultaneously treated with low-dose ketanserin. The atherosclerosis scores of the treatment group were significantly lower than those of the control group (coronary score: 0.90 ± 0.14 vs. 1.76 ± 0.27, P < 0.05; aortic scores: 1.00 ± 0.39 vs. 2.18 ± 0.41, P < 0.05). In experiment 4, male New Zealand White rabbits were fed a high-cholesterol diet and treated with low-dose ketanserin at the same time. The atherosclerosis scores of the treatment group were significantly lower than those of the control group (aortic scores: 0.26 ± 0.20 vs. 0.60 ± 0.31, P < 0.05). In conclusion, the present study demonstrated, for the first time, that low-dose ketanserin prevented the development of atherosclerosis independent of its blood pressure lowering action in SHRs and New Zealand White rabbits at least in part via enhancement of arterial baroreflex function. Key words: atherosclerosis, baroreflex, spontaneously hypertensive rats, rabbit, ketanserin. La presente etude a eu pour objectif de verifier l'hypothese qu'une faible dose de ketanserine, qui stimule l'activite du baroreflexe, a pre;venu les lesions precoces de l'atherosclerose. Dans l'experience 1, on a mesure; la sensibilite du baroreflexe (SBR) chez 31 rats spontaneement hypertendus (RSH) eveillees, en utilisant un systeme informatise: de surveillance de la pression arterielle. Quatre semaines plus tard, on a administre de la vitamine [D.sub.3] aux rats, et on les a soumis a une diete riche en cholesterol pendant 8 semaines pour induire l'atherosclerose. On a ensuite preleve les coeurs et les aortes pour les soumettre a un examen pathologique. On a trouve une correlation negative entre la SBR et les scores coronaire (r =0,460, P < 0,01) et aortique (r = -0,448,P 0< 0,05) de l'atherosclerose. Dans l'experience 2, on a divise les RSH en trois groupes (n =10 dans chaque groupe) et on leur a administre une dose de ketanserine de 0,3, 1,0 et 3,0 mg/kg (i.g.) respectivement. A la plus faible dose (0,3 mg/kg), la ketanserine n'a pas abaisse la PA, mais a augmente la SBR. Dans l'expeerience 3, on a administer de la vitamine D3 aux RSH et on les a soumis a la diete riche en cholesterol, en plus de les traiter avec la faible dose de ketanserine. Les scores d'atheerosclerose du groupe traite ont etee significativement plus faibles que ceux du groupe teemoin (scores coronaires : 0,90 ± 0,14 par rapport a 1,76 ± 0,27, P < 0,05 ; scores aortiques 1,00 ± 0,39 par rapport a 2,18 ± 0,41, P < 0,05). Dans l'experience 4, on a soumis des lapins neo-zeelandais blancs males (NZB) a la diete riche en cholesterol et on les a traites simultanement avec la faible dose de ketanserine. Les scores de l'atherosclerose du groupe traite ont ete significativement plus faibles que ceux du groupe temoin (scores aortiques : 0,26 ± 0,20 contre 0,60 ± 0,31, P < 0,05). En conclusion, cette etude est la premiere a demontrer qu'une faible dose de ketanserine a prevenu le developpement de l'atherosclerose, independamment de son action d'abaissement de la PA, chez les RSH et les lapins NZB, en partie du moins, en stimulant la fonction du baroreflexe arteriel. Mots-cles: atherosclerose, baroreflexe, rats spontanement hypertendus, lapin, ketanserine. [Traduit par la Redaction], Introduction The function of arterial baroreflex (ABR), also expressed by baroreflex sensitivity (BRS), contributes importantly to the regulation of cardiovascular activities. The dysfunction of ABR has been linked to increased [...]

Introduction: The aim of this study was to investigate how peritoneal dialysis and other influencing factors affect patients' cognitive function. Methods: The 85 subjects in the study group were regular patients in our center. The control group included 88 age and gender matched healthy individuals who were with normal renal function. The study subjects' cognitive levels and related factors were analyzed using several screening instruments: the cognitive function was measured using the Montreal Cognitive Assessment Scale and statistical analysis was conducted based on the relevant data. Results: The results showed that cognitive impairment was higher in peritoneal dialysis patients than in non‐dialysis subjects. Age and educational background were single factors that affected cognitive function, which was more likely to be impaired at a higher age level and/or a lower educational level. Conclusion: Cognitive function can be impaired by peritoneal dialysis, and age and education levels are influencing factors. [ABSTRACT FROM AUTHOR]