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993 results on '"Smith, Gregory S."'

357. Synthesis, Structure and in Vitro Biological Screening of Palladium(II) Complexes of Functionalised Salicylaldimine Thiosemicarbazones as Antimalarial and Anticancer Agents

Author

Chellan, Prinessa, primary, Shunmoogam-Gounden, Nelusha, additional, Hendricks, Denver T., additional, Gut, Jiri, additional, Rosenthal, Philip J., additional, Lategan, Carmen, additional, Smith, Peter J., additional, Chibale, Kelly, additional, and Smith, Gregory S., additional

Published
2010
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374. Synthesis of CpM(CO)3-DAB and -PAMAM Dendrimer Conjugates and Preliminary Evaluation of Their Biological Activity.

Author

Hu, Wanning, Hoyer, Jan, Neundorf, Ines, Govender, Preshendren, Smith, Gregory S., and Schatzschneider, Ulrich

Subjects
CHEMICAL synthesis, DENDRIMERS synthesis, CONJUGATED systems, ORGANOMETALLIC compounds spectra, CANCER cells
Abstract

Dendrimers of different generations and core structures [diaminobutane poly(propylenimine) (DAB) G1, G2, G3; poly(amidoamine) (PAMAM) G1] were chosen as carriers for bioactive organometallic half-sandwich complexes of the type CpM(CO)3 (Cp = cyclopentadienyl, M = Mn or Re) to study the influence of these parameters on their biological activity against cancer cells. Structure-activity relationships were determined by variation of the metal center as well as the type, molecular weight, and number of terminal functional groups of the dendrimer conjugates. All conjugates were characterized by IR and NMR spectroscopy as well as HPLC. Their biological activity was determined on MCF-7 human breast cancer cells by the resazurin assay. Interestingly, the most-active compounds were the first-generation dendrimer conjugates. The Mn and Re series showed nearly the same activities. Thus, the cytotoxicity of the dendrimer conjugates does not seem to directly correlate with the type or number of terminal functional groups. Rather, it points to a mechanism of action that is different from that previously observed for peptide conjugates with similar CpM(CO)3 functional groups. [ABSTRACT FROM AUTHOR]

Published
2015
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375. Trinuclear Half-Sandwich RuII, RhIII and IrIII Polyester Organometallic Complexes: Synthesis and in vitro Evaluation as Antitumor Agents.

Author

Burgoyne, Andrew R., Makhubela, Banothile C. E., Meyer, Mervin, and Smith, Gregory S.

Subjects
RUTHENIUM, PLATINUM group, RHODIUM, CLASS B metals, IRIDIUM
Abstract

Schiff base ligands obtained from the condensation of 4-aminophenylmethanol and either 2-pyridinecarboxaldehyde or salicylaldehyde were used to synthesise bidentate trimeric ester ligands. The trimeric ester ligands were used to prepare a new series of trinuclear polyester organometallic complexes by using the dimeric precursors, [Ru(η6- p- iPrC6H4Me)Cl2]2, [Rh(C5Me5)Cl2]2 or [Ir(C5Me5)Cl2]2. The Schiff base ligands act as bidentate donors to each metal. All compounds were characterised by NMR and IR spectroscopy, elemental analysis and EI/ESI mass spectrometry. Model mononuclear analogues were prepared, and the molecular structures of selected compounds were determined by single-crystal X-ray diffraction analysis. The mono- and trimeric ligands and the metal complexes were evaluated for inhibitory effects against the human ovarian cancer cell lines, A2780 (cisplatin-sensitive) and A2780 cisR (cisplatin-resistant), and the model human skin fibroblast cell line, KMST-6. [ABSTRACT FROM AUTHOR]

Published
2015
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397. Improving client/server computing; moving to a decentralized structure requires a break from old support model

Author

Smith, Gregory S.

Subjects
Decentralization, Network Management, System Conversion, Client/Server Architecture, Network Architecture
Abstract

As more organizations move mission-critical applications off of the mainframe, a whole array of problems arises: LAN support and administration, application development, tool selection and implementation, and user support, just […]

Published
1994

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