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Background and Objectives: The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has surprised the medical world with its devastating effects such as severe acute respiratory distress syndrome (ARDS) and cytokine storm, but also with the scant therapeutic solutions which have proven to be effective against the disease. Therapeutic plasma exchange (TPE) has been proposed from the very beginning as a possible adjuvant treatment in severe cases. Our objective was to analyze the evolution of specific biological markers of the COVID-19 disease before and one day after a therapeutic plasma exchange session, how a change in these parameters influences the patient’s respiratory status, as well as the impact of TPE on the survival rate. Materials and Methods: In this retrospective study, we include 65 patients with COVID-19 admitted to the intensive care unit department of our hospital between March 2020 and December 2021, and who received a total of 120 sessions of TPE. Results: TPE significantly reduced the following inflammation markers (p < 0.001): interleukin-6 (IL-6), C-reactive protein (CRP), lactate dehydrogenase (LDH), fibrinogen, ferritin, and erythrocyte sedimentation rate. This procedure significantly increased the number of lymphocytes and decreased D-dimers levels (p = 0.0024). TPE significantly improved the PaO2/FiO2 ratio (p < 0.001) in patients with severe acute respiratory distress syndrome (PaO2/FiO2 < 100). Survival was improved in intubated patients who received TPE. Conclusions: TPE involved the reduction in inflammatory markers in critical patients with COVID-19 disease and the improvement of the PaO2/FiO2 ratio in patients with severe ARDS and had a potential benefit on the survival of patients with extremely severe COVID-19 disease.

Thermal comfort is very important for the well-being and safety of vehicle occupants, as discomfort can elevate stress, leading to distracted attention and slower reaction times. This creates a riskier driving environment. Addressing this, high-induction air diffusers emerge as a significant innovation, enhancing indoor environmental quality (IEQ) by efficiently mixing cool air from the heating ventilation and air conditioning (HVAC) system with the cabin's ambient air. This process ensures uniform airflow, diminishes temperature discrepancies, prevents draft sensations, and boosts overall air quality by improving air circulation. In addition to enhancing thermal comfort in vehicles, the novel air diffuser also offers significant potential for personalized ventilation systems, allowing for individualized control over airflow and temperature, thereby catering to the specific comfort needs of each occupant. This study introduces a novel air diffuser that demonstrates a 48% improvement in air entrainment compared to traditional diffusers, verified through Ansys Fluent simulations and laser Doppler velocimetry (LDV) measurements. At a fresh airflow rate of 31.79 m3/h, the total air entrainment rate at 0.6 m for the standard air diffuser is 73.36 m3/h, while for the innovative air diffuser, it is 109.26 m3/h. This solution has the potential to increase the level of thermal comfort and air quality within vehicles, and also signals potential applications across various enclosed spaces, underscoring its importance in advancing automotive safety and environmental standards. [ABSTRACT FROM AUTHOR]

The secular stagnation hypothesis suggests that population aging (65+) places a drag on long-run growth, but this assertion remains a matter of debate. To address this issue, we use a panel of OECD countries for the years 1975–2014 to estimate the relationship between the old-age dependency ratio (population 65+/population 15–64) and secular growth (10- and 20-year intervals). Our empirical evidence clearly shows that the old-age dependency ratio has a negative effect on growth, confirming the demographic implications of the secular stagnation hypothesis. We also propose an overlapping generations model that explains this pattern in the data. Within this framework, optimizing households invest in their children's human capital and save for retirement. We show that an increase in the old-age dependency ratio reduces productivity through a reduction in human and physical capital as more resources are transferred to the elderly. This reduction in productivity results in slower growth and secular stagnation. [ABSTRACT FROM AUTHOR]

This is a single tertiary population-based study conducted at a center in southwest Romania. We retrospectively compared data obtained in two periods: January 2008–December 2013 and January 2018–December 2023. The global incidence of the transposition of great arteries in terminated cases, in addition to those resulting in live-born pregnancies, remained almost constant. The live-birth incidence decreased. The median gestational age at diagnosis decreased from 29.3 gestational weeks (mean 25.4) to 13.4 weeks (mean 17.2). The second trimester and the overall detection rate in the prenatal period did not significantly change, but the increase was statistically significant in the first trimester. The proportion of terminated pregnancies in fetuses diagnosed with the transposition of great arteries significantly increased (14.28% to 75%, p = 0.019). [ABSTRACT FROM AUTHOR]

In this study, the objective was to optimize energy consumption in the fused deposition modeling (FDM) 3D printing process via a detailed analysis of printing parameters. By utilizing thermal analysis techniques, this research aimed to identify lower printing temperatures that could lead to reduced energy usage. Experimental analysis was conducted using a three-level L9 Taguchi orthogonal array, which involved a systematic combination of different extruder temperatures and cooling fan capacities. Furthermore, the research incorporated differential scanning calorimetry (DSC) and X-ray diffraction (XRD) methods to analyze the thermal properties and crystallinity of the 3D-printed specimens. The results indicated that temperature was a key factor affecting crystallinity, with samples printed at 190 °C and 60% fan capacity showing the highest mean values. By conducting a multi-objective desirability analysis, the optimal conditions for maximizing ultimate tensile strength (UTS), tensile modulus, and elongation at break while minimizing energy consumption for PLA 3D-printed samples were determined to be a temperature of 180 °C and a fan speed of 80%. [ABSTRACT FROM AUTHOR]

Background: Biological invasions pose an increasing risk to nature, social security and the economy, being ranked amongst the top five threats to biodiversity. Managing alien and invasive species is a priority for the European Union, as outlined in the EU Biodiversity Strategy for 2030 and the Kunming-Montreal Global Biodiversity Framework. Alien plant species are acknowledged to impact the economy and biodiversity; thus, analysing the distribution of such species provides valuable inputs for the management and decision-making processes. The database presented in the current study is the first consolidated checklist of alien plant species that are present in Romania, both of European Union concern and of national interest. This database complements a prior published distribution, based only on records from literature, bringing new information regarding the occurrence of alien plants in Romania, as revealed by a nationwide field survey. We consider this database a valuable instrument for managing biological invasions at both national and regional levels, as it can be utilised in further research studies and in drafting management and action plans, assisting stakeholders in making informed decisions and implementing management actions. New information: We present the results of the first nationwide survey of alien plant species in Romania, conducted between 2019 and 2022, in the framework of a national project coordinated by the Ministry of Environment, Waters and Forests and the University of Bucharest. The present database complements and updates the database published by Sirbu et. al (2022), which included occurrence records published until 2019. The new database includes 98323 occurrence records for 396 alien plant species in 77 families, with most species belonging to the Asteraceae family. One alien plant species in our database, the black locust Robinia pseudoacacia L., had more than 10,000 occurrence records. The distribution database also includes information on newly-reported invasive alien plant species of European Union concern in Romania (i.e. the floating primrose-willow Ludwigia peploides (Kunth) P.H.Raven) and documents the presence of plants in 44 additional families compared to Sirbu et al. (2022). Each entry includes information on species taxonomy, location, year, person who recorded and identified the alien plant, geographical coordinates and taxon rank. [ABSTRACT FROM AUTHOR]

Background: Despite therapy advances, one of the leading causes of cancer deaths still remains lung cancer. To improve current treatments or prevent nonsmall cell lung cancer (NSCLC), the role of the nutrition in cancer onset and progression needs to be understood in more detail. While in colorectal cancer, the influence of local microbiota derived SCFAs have been well investigated, the influence of SCFA on lung cancer cells via peripheral blood immune system should be investigated more deeply. In this respect, nutrients absorbed via the gut might affect the tumor microenvironment (TME) and thus play an important role in tumor cell growth. Objective: This study focuses on the impact of the short-chain fatty acid (SCFA) Sodium Butyrate (SB), on lung cancer cell survival. We previously described a protumoral role of glucose on A549 lung adenocarcinoma cell line. In this study, we wanted to know if SB would counteract the effect of glucose and thus cultured A549 and H520 in vitro with and without SB in the presence or absence of glucose and investigated how the treatment with SB affects the survival of lung cancer cells and its influence on immune cells fighting against lung cancer. Methods: In this study, we performed cell culture experiments with A549, H520 and NSCLC-patient-derived epithelial cells under different SB levels. To investigate the influence on the immune system, we performed in vitro culture of peripheral mononuclear blood cells (PBMC) from control, smoker and lung cancer patients with increasing SB concentrations. Results: To investigate the effect of SB on lung tumor cells, we first analyzed the effect of 6 different concentrations of SB on A549 cells at 48 and 72 hours cell culture. Here we found that, SB treatment reduced lung cancer cell survival in a concentration dependent manner. We next focused our deeper analysis on the two concentrations, which caused the maximal reduction in cell survival. Here, we observed that SB led to cell cycle arrest and induced early apoptosis in A549 lung cancer cells. The expression of cell cycle regulatory proteins and A549 lung cancer stem cell markers (CD90) was induced. Additionally, this study explored the role of interferon-gamma (IFN-g) and its receptor (IFN-g-R1) in combination with SB treatment, revealing that, although IFN-g-R1 expression was increased, IFN-g did not affect the efficacy of SB in reducing tumor cell viability. Furthermore, we examined the effects of SB on immune cells, specifically CD8 + T cells and natural killer (NK) cells from healthy individuals, smokers, and NSCLC patients. SB treatment resulted in a decreased production of IFN-g and granzyme B in CD8+ T cells and NK cells. Moreover, SB induced IFN-g-R1 in NK cells and CD4+ T cells in the absence of glucose both in PBMCs from controls and NSCLC subjects. Conclusion: Overall, this study highlights the potential of SB in inhibiting lung cancer cell growth, triggering apoptosis, inducing cell cycle arrest, and modulating immune responses by activating peripheral blood CD4+ T cells while selectively inducing IFN-g-R1 in NK cells in peripheral blood and inhibiting peripheral blood CD8+ T cells and NK cells. Thus, understanding the mechanisms of action of SB in the TME and its influence on the immune system provide valuable insights of potentially considering SB as a candidate for adjunctive therapies in NSCLC. [ABSTRACT FROM AUTHOR]

Background: Double-lumen tubes (DLTs) are the preferred device for lung isolation. Conventional DLTs (cDLT) need a bronchoscopic position control. Visualisation of correct DLT positioning could be facilitated by the use of a video double-lumen tube (vDLT). During the SARS-CoV-2-pandemic, avoiding aerosol-generation was suggesting using this device. In a large retrospective series, we report both general and pandemic related experiences with the device. Methods: All anesthesia records from patients aged 18 years or older undergoing surgery from April 1st, 2020 to December 31st, 2021 in the department of thoracic surgery requiring intraoperative lung isolation were analyzed retrospectively. Results: During the investigation period 343 left-sided vDLTs (77.4%) and 100 left-sided cDLTs (22.6%) were used for one lung ventilation. In the vDLT group bronchoscopy could be reduced by 85.4% related to the cDLT group. Additional bronchoscopy to reach or maintain correct position was needed in 11% of the cases. Other bronchoscopy indications occured in 3.6% of the cases. With cDLT, in 1% bronchoscopy for other indications than conforming position was observed. Conclusions: The Ambu® VivaSight™ vDLT is an efficient, easy-to-use and safe airway device for the generation of one lung ventilation in patients undergoing thoracic surgery. The vDLT implementation was achieved easily with full interchangeability to the left-sided cDLT. Using the vDLT can reduce the need for aerosol-generating bronchoscopic interventions by 85.4%. Continuous video view to the carina enabling position monitoring of the DLT without need for bronchoscopy might be beneficial for both employee's and patient's safety. [ABSTRACT FROM AUTHOR]

The trends, challenges and global guidelines facing agriculture and the agri-food system are multiple, a process of reflection by decision-makers, researches and businessmen being timely and necessary. The expansion of the agricultural and agri-food sector may be significantly limited by the already existing pressure on agricultural land and water resources. Innovative production models are needed to increase productivity while maintaining biodiversity and the quality of natural resources. Aquaponics can be considered a sustainable agricultural production system because it combines plant and animal production, integrates the flow of nutrients through natural biological cycles of nitrification, is carried out without exhausting available resources and without destroying the environment, so without compromising the possibilities of satisfaction of the needs of future generations. [ABSTRACT FROM AUTHOR]

Emerging technologies based on polymeric materials are progressively developed in order to preserve and consolidate cultural heritage artifacts. In this study, we aimed to obtain a hybrid polymer reliant on two types of thermosets that undergo irreversible crosslinking via ionizing radiation-induced polymerization, the polymer's structure and characteristics being tailored using specific dose rates, doses, linear energy transfer and monomers ratio, in order to achieve the established performance requirements. Here, we demonstrate a covalently bonded 3D hybrid diepoxy-triacrylic polymer that is chemically and dimensionally stable, intending to use it as a consolidant of highly degraded wooden artifacts in order to mitigate oxygen inhibition from radical chain reactions, to increase chemical and thermal stability, as well as to obtain a stiffer consolidated artifact, therefore more resistant to deformation. Various types of analytical techniques such as Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy, Mass Spectrometry or Thermal analysis were performed in order to support our strategy and predictions regarding the synergistic effect given by gamma irradiation-driven crosslinking through simultaneous cationic and radical chain growth polymerization reaction mechanisms. We achieved a homogenous polymeric formulation and wood-polymer composite materials with high modulus of elasticity, therefore providing up to a twofold increase in Young's modulus in the consolidated wood, a good chemical resistance to various solvents and outstanding thermal resistance up to 381°C. Consequently, the consolidation methodology, as well as mechanical testing, analytical and morphological characterization of the resulted composite will be discussed. Apart from consolidating cultural heritage wooden artifacts, this synthetic route and impregnation methodology provide opportunities for wood-polymer composites in a wealth of applications as reinforced wood-based materials. [ABSTRACT FROM AUTHOR]

This article, published in the Romanian Journal of Oral Rehabilitation, explores the role of IGF1 in childhood osteosarcomas. The study analyzed samples from patients diagnosed with osteosarcoma and found that all cases showed overexpression of IGF1. The researchers suggest that IGF1 may contribute to the development and progression of osteosarcoma and could potentially be targeted for personalized treatment. The document provides information on osteosarcoma, including its prevalence in males and its common occurrence in the femur and tibia. It also discusses the histological diagnosis of osteosarcoma and the potential therapeutic implications of IGF1 overexpression. [Extracted from the article]

The mechanisms of variation of intraocular pressure (IOP) during abdominal surgical interventions it is not completely clear and its result on the recovering patient may vary from benign alterations to disabilities. This review aims to identify the most important triggers and its impact of IOP along with individual risk factors during the perioperative period of abdominal surgeries. International literature is providing limited data on this topic. We reviewed 9 studies using PubMed, Scopus, and Web of Science as database. From the multitude of effects and implications that abdominal surgery has onto the physiology of eyeball, the highest impact was linked to the positioning of the patient, induction of anesthesia, perianesthetic events such as intubation and extubation, type of anesthesia and anesthetic used, pneumoperitoneum induced in laparoscopic surgeries and its contribution to the alterations of ocular parameters which are increasing the risk of ocular events. In addition to this, the association of individual risk factors as well as the pre-existing of ophthalmologic diseases may have severe consequences onto the visual function.