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351. Analysis of the Distribution and Temporal Trends of Grade and Stage in Urothelial Bladder Cancer in Northern New England from 1994 to 2004

Author

Schned, Alan R., primary, Lenz, Petra, additional, Moore, Lee E., additional, Johnson, Alison, additional, Jones, Michael, additional, Kida, Masatoshi, additional, Silverman, Debra T., additional, Schwenn, Molly, additional, Kelsey, Karl T., additional, Andrew, Angeline S., additional, Baris, Dalsu, additional, and Karagas, Margaret R., additional

Published
2012
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352. Abstract LB-337: Synergistic effects of twelve common genetic polymorphisms and smoking habits on absolute risk of bladder cancer

Author

García-Closas, M., primary, Rothman, N., additional, Figueroa, J. D., additional, Prokunina-Olsson, L., additional, Han, S., additional, Baris, D., additional, Jacobs, E., additional, Malats, N., additional, Vivo, I. De, additional, Albanes, D., additional, Purdue, M. P., additional, Sharma, S., additional, Fu, Y. P., additional, Kogevinas, M., additional, Wang, Z., additional, Tang, W., additional, Tardón, A., additional, Serra, C., additional, Carrato, A., additional, García-Closas, R., additional, Lloreta, J., additional, Johnson, A., additional, Schwenn, M., additional, Karagas, M. R., additional, Schned, A., additional, Andriole, G., additional, Grubb, R., additional, Black, A., additional, Gapstur, S. M., additional, Thun, M., additional, Diver, W. R., additional, Weinstein, S. J., additional, Virtamo, J., additional, Hunter, D. J., additional, Caporaso, N., additional, Landi, M. T., additional, Hutchinson, A., additional, Burdett, L., additional, Jacobs, K. B., additional, Yeager, M., additional, Fraumeni, J. F., additional, Chanock, S. J., additional, Silverman, D. T., additional, and Chatterjee, N., additional

Published
2012
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354. Common genetic variants in the PSCA gene influence gene expression and bladder cancer risk

Author

Fu, Yi-Ping, primary, Kohaar, Indu, additional, Rothman, Nathaniel, additional, Earl, Julie, additional, Figueroa, Jonine D., additional, Ye, Yuanqing, additional, Malats, Núria, additional, Tang, Wei, additional, Liu, Luyang, additional, Garcia-Closas, Montserrat, additional, Muchmore, Brian, additional, Chatterjee, Nilanjan, additional, Tarway, McAnthony, additional, Kogevinas, Manolis, additional, Porter-Gill, Patricia, additional, Baris, Dalsu, additional, Mumy, Adam, additional, Albanes, Demetrius, additional, Purdue, Mark P., additional, Hutchinson, Amy, additional, Carrato, Alfredo, additional, Tardón, Adonina, additional, Serra, Consol, additional, García-Closas, Reina, additional, Lloreta, Josep, additional, Johnson, Alison, additional, Schwenn, Molly, additional, Karagas, Margaret R., additional, Schned, Alan, additional, Diver, W. Ryan, additional, Gapstur, Susan M., additional, Thun, Michael J., additional, Virtamo, Jarmo, additional, Chanock, Stephen J., additional, Fraumeni, Joseph F., additional, Silverman, Debra T., additional, Wu, Xifeng, additional, Real, Francisco X., additional, and Prokunina-Olsson, Ludmila, additional

Published
2012
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356. Mapping of the UGT1A locus identifies an uncommon coding variant that affects mRNA expression and protects from bladder cancer

Author

Tang, Wei, primary, Fu, Yi-Ping, additional, Figueroa, Jonine D., additional, Malats, Núria, additional, Garcia-Closas, Montserrat, additional, Chatterjee, Nilanjan, additional, Kogevinas, Manolis, additional, Baris, Dalsu, additional, Thun, Michael, additional, Hall, Jennifer L., additional, De Vivo, Immaculata, additional, Albanes, Demetrius, additional, Porter-Gill, Patricia, additional, Purdue, Mark P., additional, Burdett, Laurie, additional, Liu, Luyang, additional, Hutchinson, Amy, additional, Myers, Timothy, additional, Tardón, Adonina, additional, Serra, Consol, additional, Carrato, Alfredo, additional, Garcia-Closas, Reina, additional, Lloreta, Josep, additional, Johnson, Alison, additional, Schwenn, Molly, additional, Karagas, Margaret R., additional, Schned, Alan, additional, Black, Amanda, additional, Jacobs, Eric J., additional, Diver, W. Ryan, additional, Gapstur, Susan M., additional, Virtamo, Jarmo, additional, Hunter, David J., additional, Fraumeni, Joseph F., additional, Chanock, Stephen J., additional, Silverman, Debra T., additional, Rothman, Nathaniel, additional, and Prokunina-Olsson, Ludmila, additional

Published
2012
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357. Large-Scale Pathway-Based Analysis of Bladder Cancer Genome-Wide Association Data from Five Studies of European Background

Author

Menashe, Idan, primary, Figueroa, Jonine D., additional, Garcia-Closas, Montserrat, additional, Chatterjee, Nilanjan, additional, Malats, Nuria, additional, Picornell, Antoni, additional, Maeder, Dennis, additional, Yang, Qi, additional, Prokunina-Olsson, Ludmila, additional, Wang, Zhaoming, additional, Real, Francisco X., additional, Jacobs, Kevin B., additional, Baris, Dalsu, additional, Thun, Michael, additional, Albanes, Demetrius, additional, Purdue, Mark P., additional, Kogevinas, Manolis, additional, Hutchinson, Amy, additional, Fu, Yi-Ping, additional, Tang, Wei, additional, Burdette, Laurie, additional, Tardón, Adonina, additional, Serra, Consol, additional, Carrato, Alfredo, additional, García-Closas, Reina, additional, Lloreta, Josep, additional, Johnson, Alison, additional, Schwenn, Molly, additional, Schned, Alan, additional, Andriole, Gerald, additional, Black, Amanda, additional, Jacobs, Eric J., additional, Diver, Ryan W., additional, Gapstur, Susan M., additional, Weinstein, Stephanie J., additional, Virtamo, Jarmo, additional, Caporaso, Neil E., additional, Landi, Maria Teresa, additional, Fraumeni, Joseph F., additional, Chanock, Stephen J., additional, Silverman, Debra T., additional, and Rothman, Nathaniel, additional

Published
2012
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358. Team managed outpatient care for early onset chronic inflammatory arthritis

Author

E S, Schned, M A, Doyle, S L, Glickstein, J T, Schousboe, J L, Reinertsen, A J, Baglioni, and T F, Tolson

Subjects
Adult, Male, Patient Care Team, Treatment Outcome, Evaluation Studies as Topic, Arthritis, Ambulatory Care, Humans, Female, Health Care Costs, Middle Aged
Abstract

To determine whether an outpatient team management program for persons with early chronic inflammatory arthritis would produce improved clinical outcomes and lower costs than traditional, nonteam outpatient rheumatologic care in a clinic setting.One hundred eighteen patients with chronic inflammatory arthritis were randomly assigned to a team managed outpatient care program (TEAMCARE) or to traditional, one on one, nonteam managed rheumatologic care (TRADCARE). The TEAMCARE program consisted of a half day educational program, a needs assessment intake interview, and quarterly telephone calls, monthly team meetings, and routine rheumatologic care. TRADCARE patient received unconstrained, routine primary and specialty outpatient care as practised typically by rheumatologists at this large multi-specialty clinic. All patients had numerous physical and laboratory outcome assessments by rheumatologists at office visit. Every 6 months, patients completed several self-report measures of functional status, pain, psychosocial status, and costs.One hundred seven patients completed one year of study participation. No significant differences were found between groups in measures of physical status, physical functioning, psychosocial status, or pain. There were no differences between groups in economic or utilization measures.This team managed outpatient program for persons with recent onset chronic inflammatory arthritis afforded no advantage to routine outpatient care, characterized mainly by one on one relationships between patients and primary care doctors and rheumatologists, in our active outpatient clinical environment.

Published
1995

359. Abstract A66: Apoptosis, cell cycle, DNA repair, immune, and metabolism pathway SNPs modify bladder cancer risk, recurrence, and survival

Author

Andrew, Angeline S., primary, Gui, Jiang, additional, Moore, Jason H., additional, Karagas, Margaret R., additional, Pendleton, Eben, additional, Schned, Alan R., additional, Mason, Rebecca A., additional, Wyszynski, Asaf, additional, Tanyos, Sam A., additional, Kelsey, Karl T., additional, Marsit, Carmen J., additional, and Zens, Michael S., additional

Published
2011
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360. SLC39A2 and FSIP1 polymorphisms as potential modifiers of arsenic-related bladder cancer

Author

Karagas, Margaret R., primary, Andrew, Angeline S., additional, Nelson, Heather H., additional, Li, Zhongze, additional, Punshon, Tracy, additional, Schned, Alan, additional, Marsit, Carmen J., additional, Morris, J. Steven, additional, Moore, Jason H., additional, Tyler, Anna L., additional, Gilbert-Diamond, Diane, additional, Guerinot, Mary-Lou, additional, and Kelsey, Karl T., additional

Published
2011
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361. An unusual suspect: an uncommon human-specific synonymous coding variant within the UGT1A6 gene explains a GWAS signal and protects against bladder cancer

Author

Tang, Wei, primary, Fu, Yi-Ping, additional, Figueroa, Jonine D, additional, Malats, Núria, additional, Garcia-Closas, Montserrat, additional, Chatterjee, Nilanjan, additional, Kogevinas, Manolis, additional, Baris, Dalsu, additional, Thun, Michael, additional, Hall, Jennifer L, additional, De Vivo, Immaculata, additional, Albanes, Demetrius, additional, Porter-Gill, Patricia, additional, Purdue, Mark P, additional, Burdett, Laurie, additional, Liu, Luyang, additional, Hutchinson, Amy, additional, Myers, Timothy, additional, Tardón, Adonina, additional, Serra, Consol, additional, Carrato, Alfredo, additional, Garcia-Closas, Reina, additional, Lloreta, Josep, additional, Johnson, Alison, additional, Schwenn, Molly, additional, Karagas, Margaret R, additional, Schned, Alan, additional, Black, Amanda, additional, Jacobs, Eric J, additional, Diver, W Ryan, additional, Gapstur, Susan M, additional, Virtamo, Jarmo, additional, Hunter, David J, additional, Fraumeni, Joseph F, additional, Chanock, Stephen J, additional, Silverman, Debra T, additional, Rothman, Nathaniel, additional, and Prokunina-Olsson, Ludmila, additional

Published
2011
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362. Hair dye use and risk of bladder cancer in the New England bladder cancer study

Author

Koutros, Stella, primary, Silverman, Debra T., additional, Baris, Dalsu, additional, Zahm, Shelia Hoar, additional, Morton, Lindsay M., additional, Colt, Joanne S., additional, Hein, David W., additional, Moore, Lee E., additional, Johnson, Alison, additional, Schwenn, Molly, additional, Cherala, Sai, additional, Schned, Alan, additional, Doll, Mark A., additional, Rothman, Nathaniel, additional, and Karagas, Margaret R., additional

Published
2011
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363. A genome-wide association study of bladder cancer identifies a new susceptibility locus within SLC14A1, a urea transporter gene on chromosome 18q12.3

Author

Garcia-Closas, Montserrat, primary, Ye, Yuanqing, additional, Rothman, Nathaniel, additional, Figueroa, Jonine D., additional, Malats, Núria, additional, Dinney, Colin P., additional, Chatterjee, Nilanjan, additional, Prokunina-Olsson, Ludmila, additional, Wang, Zhaoming, additional, Lin, Jie, additional, Real, Francisco X., additional, Jacobs, Kevin B., additional, Baris, Dalsu, additional, Thun, Michael, additional, De Vivo, Immaculata, additional, Albanes, Demetrius, additional, Purdue, Mark P., additional, Kogevinas, Manolis, additional, Kamat, Ashish M., additional, Lerner, Seth P., additional, Barton Grossman, H., additional, Gu, Jian, additional, Pu, Xia, additional, Hutchinson, Amy, additional, Fu, Yi-Ping, additional, Burdett, Laurie, additional, Yeager, Meredith, additional, Tang, Wei, additional, Tardón, Adonina, additional, Serra, Consol, additional, Carrato, Alfredo, additional, García-Closas, Reina, additional, Lloreta, Josep, additional, Johnson, Alison, additional, Schwenn, Molly, additional, Karagas, Margaret R., additional, Schned, Alan, additional, Andriole, Gerald, additional, Grubb, Robert, additional, Black, Amanda, additional, Jacobs, Eric J., additional, Ryan Diver, W., additional, Gapstur, Susan M., additional, Weinstein, Stephanie J., additional, Virtamo, Jarmo, additional, Hunter, David J., additional, Caporaso, Neil, additional, Teresa Landi, Maria, additional, Fraumeni, Joseph F., additional, Silverman, Debra T., additional, Chanock, Stephen J., additional, and Wu, Xifeng, additional

Published
2011
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371. PRIAPISM IN A 15-YEAR-OLD BOY WITH CONGENITAL DYSERYTHROPOIETIC ANEMIA TYPE II (HEREDITARY ERYTHROBLASTIC MULTINUCLEARITY WITH POSITIVE ACIDIFIED SERUM LYSIS TEST)

Author

Pamela I. Ellsworth, Sara Chaffee, Marc Cendron, Alan R. Schned, and Mark T. Edney

Subjects
Ineffective erythropoiesis, medicine.medical_specialty, Chemotherapy, Congenital dyserythropoietic anemia type II, Anemia, business.industry, medicine.medical_treatment, Urology, Priapism, medicine.disease_cause, medicine.disease, Gastroenterology, Endocrinology, medicine.anatomical_structure, hemic and lymphatic diseases, Internal medicine, medicine, Bone marrow, business, Congenital dyserythropoietic anemia, Dyserythropoietic anemia
Abstract

Congenital dyserythropoietic anemia encompasses a group of related disorders characterized by ineffective erythropoiesis, bone marrow erythroblastic multinuclearity and secondary hemochromatosis. Type II, the most common variation, is called hereditary erythroblastic multinuclearity with positive acidified serum lysis test (HEMPAS). To our knowledge this is the first reported case of priapism associated with HEMPAS.

Published
2002

374. GSTM1 null and NAT2 slow acetylation genotypes, smoking intensity and bladder cancer risk: results from the New England bladder cancer study and NAT2 meta-analysis

Author

Moore, L. E., primary, Baris, D. R., additional, Figueroa, J. D., additional, Garcia-Closas, M., additional, Karagas, M. R., additional, Schwenn, M. R., additional, Johnson, A. T., additional, Lubin, J. H., additional, Hein, D. W., additional, Dagnall, C. L., additional, Colt, J. S., additional, Kida, M., additional, Jones, M. A., additional, Schned, A. R., additional, Cherala, S. S., additional, Chanock, S. J., additional, Cantor, K. P., additional, Silverman, D. T., additional, and Rothman, N., additional

Published
2010
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375. A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci

Author

Rothman, Nathaniel, primary, Garcia-Closas, Montserrat, additional, Chatterjee, Nilanjan, additional, Malats, Nuria, additional, Wu, Xifeng, additional, Figueroa, Jonine D, additional, Real, Francisco X, additional, Van Den Berg, David, additional, Matullo, Giuseppe, additional, Baris, Dalsu, additional, Thun, Michael, additional, Kiemeney, Lambertus A, additional, Vineis, Paolo, additional, De Vivo, Immaculata, additional, Albanes, Demetrius, additional, Purdue, Mark P, additional, Rafnar, Thorunn, additional, Hildebrandt, Michelle A T, additional, Kiltie, Anne E, additional, Cussenot, Olivier, additional, Golka, Klaus, additional, Kumar, Rajiv, additional, Taylor, Jack A, additional, Mayordomo, Jose I, additional, Jacobs, Kevin B, additional, Kogevinas, Manolis, additional, Hutchinson, Amy, additional, Wang, Zhaoming, additional, Fu, Yi-Ping, additional, Prokunina-Olsson, Ludmila, additional, Burdett, Laurie, additional, Yeager, Meredith, additional, Wheeler, William, additional, Tardón, Adonina, additional, Serra, Consol, additional, Carrato, Alfredo, additional, García-Closas, Reina, additional, Lloreta, Josep, additional, Johnson, Alison, additional, Schwenn, Molly, additional, Karagas, Margaret R, additional, Schned, Alan, additional, Andriole, Gerald, additional, Grubb, Robert, additional, Black, Amanda, additional, Jacobs, Eric J, additional, Diver, W Ryan, additional, Gapstur, Susan M, additional, Weinstein, Stephanie J, additional, Virtamo, Jarmo, additional, Cortessis, Victoria K, additional, Gago-Dominguez, Manuela, additional, Pike, Malcolm C, additional, Stern, Mariana C, additional, Yuan, Jian-Min, additional, Hunter, David J, additional, McGrath, Monica, additional, Dinney, Colin P, additional, Czerniak, Bogdan, additional, Chen, Meng, additional, Yang, Hushan, additional, Vermeulen, Sita H, additional, Aben, Katja K, additional, Witjes, J Alfred, additional, Makkinje, Remco R, additional, Sulem, Patrick, additional, Besenbacher, Soren, additional, Stefansson, Kari, additional, Riboli, Elio, additional, Brennan, Paul, additional, Panico, Salvatore, additional, Navarro, Carmen, additional, Allen, Naomi E, additional, Bueno-de-Mesquita, H Bas, additional, Trichopoulos, Dimitrios, additional, Caporaso, Neil, additional, Landi, Maria Teresa, additional, Canzian, Federico, additional, Ljungberg, Borje, additional, Tjonneland, Anne, additional, Clavel-Chapelon, Francoise, additional, Bishop, David T, additional, Teo, Mark T W, additional, Knowles, Margaret A, additional, Guarrera, Simonetta, additional, Polidoro, Silvia, additional, Ricceri, Fulvio, additional, Sacerdote, Carlotta, additional, Allione, Alessandra, additional, Cancel-Tassin, Geraldine, additional, Selinski, Silvia, additional, Hengstler, Jan G, additional, Dietrich, Holger, additional, Fletcher, Tony, additional, Rudnai, Peter, additional, Gurzau, Eugen, additional, Koppova, Kvetoslava, additional, Bolick, Sophia C E, additional, Godfrey, Ashley, additional, Xu, Zongli, additional, Sanz-Velez, José I, additional, D García-Prats, María, additional, Sanchez, Manuel, additional, Valdivia, Gabriel, additional, Porru, Stefano, additional, Benhamou, Simone, additional, Hoover, Robert N, additional, Fraumeni, Joseph F, additional, Silverman, Debra T, additional, and Chanock, Stephen J, additional

Published
2010
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376. Occupation and bladder cancer in a population-based case-control study in Northern New England

Author

Colt, J. S., primary, Karagas, M. R., additional, Schwenn, M., additional, Baris, D., additional, Johnson, A., additional, Stewart, P., additional, Verrill, C., additional, Moore, L. E., additional, Lubin, J., additional, Ward, M. H., additional, Samanic, C., additional, Rothman, N., additional, Cantor, K. P., additional, Beane Freeman, L. E., additional, Schned, A., additional, Cherala, S., additional, and Silverman, D. T., additional

Published
2010
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379. Identification of Methylated Genes Associated with Aggressive Bladder Cancer

Author

Marsit, Carmen J., primary, Houseman, E. Andres, additional, Christensen, Brock C., additional, Gagne, Luc, additional, Wrensch, Margaret R., additional, Nelson, Heather H., additional, Wiemels, Joseph, additional, Zheng, Shichun, additional, Wiencke, John K., additional, Andrew, Angeline S., additional, Schned, Alan R., additional, Karagas, Margaret R., additional, and Kelsey, Karl T., additional

Published
2010
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380. Abstract 156: Implications of LINE1 methylation for bladder cancer risk in women

Author

Wilhelm, Charlotte S., primary, Kelsey, Karl T., additional, Butler, Rondi, additional, Plaza, Silvia, additional, Gagne, Luc, additional, Zens, Michael S., additional, Andrew, Angeline A., additional, Morris, Steven, additional, Nelson, Heather H., additional, Schned, Alan R., additional, Karagas, Margaret R., additional, and Marsit, Carmen J., additional

Published
2010
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384. Implications of LINE1 Methylation for Bladder Cancer Risk in Women

Author

Wilhelm, Charlotte S., primary, Kelsey, Karl T., additional, Butler, Rondi, additional, Plaza, Silvia, additional, Gagne, Luc, additional, Zens, M. Scot, additional, Andrew, Angeline S., additional, Morris, Steven, additional, Nelson, Heather H., additional, Schned, Alan R., additional, Karagas, Margaret R., additional, and Marsit, Carmen J., additional

Published
2010
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386. Abstract A66: Apoptosis, cell cycle, DNA repair, immune, and metabolism pathway SNPs modify bladder cancer risk, recurrence, and survival

Author

Rebecca A. Mason, Margaret R. Karagas, Eben M. Pendleton, Michael S. Zens, Angeline S. Andrew, Asaf Wyszynski, Karl T. Kelsey, Jiang Gui, Alan R. Schned, Carmen J. Marsit, Sam A. Tanyos, and Jason H. Moore

Subjects
Oncology, Cancer Research, medicine.medical_specialty, Bladder cancer, Multifactor dimensionality reduction, DNA repair, Cancer, Biology, Cell cycle, DNA repair protein XRCC4, medicine.disease, Transitional cell carcinoma, Internal medicine, Immunology, Genotype, medicine
Abstract

Bladder cancer is the fourth most common malignancy in U.S. men. Current treatments for non-invasive bladder tumors often appear initially effective, yet the rates of recurrent disease are high. Clinically useful predictors of the recurrent bladder cancer phenotype have not yet been identified. Major biological processes involved in bladder carcinogenesis include apoptosis, cell cycle, DNA repair, immune surveillance, and xenobiotic metabolism. We hypothesized that genetic variation in genes involved in each of these pathways may modify bladder cancer susceptibility and prognosis. Methods: To examine the independent and interacting effects, we analyzed variant genotypes hypothesized to modify these processes in 818 transitional cell carcinoma cases and 1167 controls enrolled in a case – control study of incident bladder cancer conducted in New Hampshire, U.S.A. Cases were followed over time to ascertain recurrence and survival status. We evaluated gene–gene interactions using Multifactor Dimensionality Reduction (MDR). Results: In the metabolism pathway, the variant form of the metabolism gene HSD3B2 was associated with increased risk (adjusted OR 1.85 95%CI 1.31–2.62) and ALDH2 variants had shorter time to first bladder cancer recurrence (adjusted HR non-invasive 1.94 95%CI 1.32–2.84). We observed longer survival among bladder cancer cases with non-invasive tumors associated with DNA repair XRCC4 heterozygous genotype compared with wildtype (adjusted HR 0.53 95%CI 0.38–0.74) and for invasive cases for immune pathway GATA3 heterozygotes (adjusted HR 0.11 95%CI 0.03–0.39). Conclusions: Our analysis suggests candidate SNPs for further clinical evaluation as prognostic markers and may lead to more personalized bladder cancer surveillance guidelines. Citation Information: Cancer Prev Res 2011;4(10 Suppl):A66.

Published
2011

387. Extracellular proteases in renal cell carcinoma

Author

B. Petrella, Jiang Gui, A. Schned, John D. Seigne, Marc S. Ernstoff, and Brea Lipe

Subjects
chemistry.chemical_classification, Cancer Research, Proteases, Pathology, medicine.medical_specialty, Biology, Matrix metalloproteinase, medicine.disease, Metastasis, Extracellular matrix, Enzyme, Oncology, chemistry, Renal cell carcinoma, Extracellular, Cancer research, medicine, Tumor growth
Abstract

363 Background: Tumor growth and metastasis relies on extracellular matrix remodeling, which is primarily mediated by the matrix metalloproteinase (MMP) family of enzymes. Extracellular matrix metalloprotease inducer (EMMPRIN, E) is a glycoprotein also implicated in tumor progression and has been shown to function in concert with MMPs. MMPs and E are highly expressed on the surface of many malignant tumors, including renal cell carcinoma (RCC). We investigated whether MMPs and E represent molecular prognostic factors in RCC. Methods: Protein expression was evaluated in 77 patients with immunohistochemical analysis of a tissue microarray (TMA) consisting of two tumor samples and an adjacent normal renal sample from each patient. Tumors represented on the TMA were clear cell (57), chromophobe (9), papillary (4), oncocytomas (3), clear cell with sarcomatoid differentiation (2), and metastatic (2). Protein expression scores were correlated with clinical outcomes to determine prognostic significance by univariate and multivariate analyses. Results: Using univariate analysis of all RCC tumors, membranous E correlated with overall survival (OS), metastasis-free survival (MFS), size, stage and overall 5-yr survival. Cytoplasmic E correlated with OS, MFS, size, grade, stage and 5-yr survival. Membranous MT1-MMP correlated with MFS, and endothelial MMP-2 correlated with grade. In multivariate analysis, membranous E was an independent indicator of stage, whereas cytoplasmic E was an independent indicator for size, stage, grade and MFS. In the clear cell population, membranous MT1-MMP correlated with OS and MFS, and endothelial MMP-2 correlated with grade in univariate analysis. In multivariate analysis, membranous MT1-MMP was an independent indicator for MFS. Conclusions: We identified EMMPRIN as an independent prognostic indicator for size, grade, stage, and MFS in RCC. While MT1-MMP and MMP-2 both significantly correlated with disease outcome in the clear cell RCC population, only MT1-MMP was an independent prognostic factor for MFS. We conclude that MMPs and E mediate important steps in RCC progression. Further investigation is warranted using larger datasets and a prospective study to determine the strength of the prognostic significance of these findings. No significant financial relationships to disclose.

Published
2011

388. Novel Single Nucleotide Polymorphisms Related to Arsenic-associated Bladder Cancer in a US Population-based Study

Author

Carmen J. Marsit, Karl T. Kelsey, Alan R. Schned, Margaret R. Karagas, J. Steven Morris, Angeline S. Andrew, Heather H. Nelson, Jason H. Moore, Mary Lou Guerinot, and Tracy Punshon

Subjects
Population based study, Bladder cancer, chemistry, Epidemiology, Cancer research, medicine, chemistry.chemical_element, Single-nucleotide polymorphism, Biology, medicine.disease, Arsenic
Published
2011

390. Nucleolar organizer regions as discriminators for the diagnosis of well-differentiated adenocarcinoma of the prostate

Author

A R, Schned

Subjects
Male, Silver Staining, Nucleolus Organizer Region, Humans, Prostatic Neoplasms, Adenocarcinoma
Abstract

This study sought to determine whether nucleolar organizer region (NOR) counts might be of diagnostic use specifically in the frequently difficult identification of well-differentiated prostate cancer. Total silver-stained NOR (AgNOR) counts on sections were done in 50 consecutive nuclei from 22 cases of well-differentiated adenocarcinoma composed exclusively of Gleason grades 1 or 2 and in 50 consecutive nuclei in foci of benign glands on the same slide. Malignant nuclei contained a mean of 4.84 AgNORs; benign nuclei, 3.39 AgNORs. This difference was statistically highly significant (P.0001), but there was considerable overlap of mean AgNOR counts between malignant and benign groups. Thus, to obtain a rule requiring a specificity of greater than 95% using the mean AgNOR count as a definition of malignancy, the maximum sensitivity possible was only 32%. Despite the overlap in mean AgNOR counts, however, in all but one case the mean count for malignant nuclei was greater than that for benign nuclei. This suggests that the diagnostic potential of AgNOR counts might be better realized by a comparison of counts between a suspicious focus and an adjacent focus of benign glands.

Published
1993

391. Derivation of the SLEDAI

Author

S L Glickstein, M. A. T. Doyle, and E S Schned

Subjects
medicine.medical_specialty, Lupus erythematosus, business.industry, Immunology, MEDLINE, medicine.disease, Severity of Illness Index, Rheumatology, Internal medicine, Severity of illness, medicine, Immunology and Allergy, Humans, Lupus Erythematosus, Systemic, Pharmacology (medical), Derivation, business
Published
1993

393. Reply

Author

Ernstoff, Marc S., primary, Fisher, Jan, additional, Seigne, John D., additional, Szczepiorkowski, Zbigniew M., additional, Crosby, Nancy A., additional, Schned, Alan R., additional, Harris, Robert D., additional, Barth, Richard J., additional, Heaney, John A., additional, Schwaab, Thomas, additional, Schwarzer, Adrian, additional, Wolf, Benita, additional, and Noelle, Randolph J., additional

Published
2009
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394. A Case–Control Study of Smoking and Bladder Cancer Risk: Emergent Patterns Over Time

Author

Baris, Dalsu, primary, Karagas, Margaret R., additional, Verrill, Castine, additional, Johnson, Alison, additional, Andrew, Angeline S., additional, Marsit, Carmen J., additional, Schwenn, Molly, additional, Colt, Joanne S., additional, Cherala, Sai, additional, Samanic, Claudine, additional, Waddell, Richard, additional, Cantor, Kenneth P., additional, Schned, Alan, additional, Rothman, Nathaniel, additional, Lubin, Jay, additional, Fraumeni, Joseph F., additional, Hoover, Robert N., additional, Kelsey, Karl T., additional, and Silverman, Debra T., additional

Published
2009
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395. Occupation and Bladder Cancer in a Population-Based Case-Control Study in Northern New England

Author

Colt, Joanne, primary, Karagas, Margaret, additional, Schwenn, Molly, additional, Baris, Dalsu, additional, Johnson, Alison, additional, Stewart, Patricia, additional, Verrill, Castine, additional, Moore, Lee, additional, Lubin, Jay, additional, Ward, Mary, additional, Samanic, Claudine, additional, Rothman, Nathaniel, additional, Cantor, Kenneth, additional, Freeman, Laura Beane, additional, Schned, Alan, additional, Cherala, Sai, additional, and Silverman, Debra, additional

Published
2009
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399. Erratum: Corrigendum: Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer

Author

Wu, Xifeng, primary, Ye, Yuanqing, additional, Kiemeney, Lambertus A, additional, Sulem, Patrick, additional, Rafnar, Thorunn, additional, Matullo, Giuseppe, additional, Seminara, Daniela, additional, Yoshida, Teruhiko, additional, Saeki, Norihisa, additional, Andrew, Angeline S, additional, Dinney, Colin P, additional, Czerniak, Bogdan, additional, Zhang, Zuo-feng, additional, Kiltie, Anne E, additional, Bishop, D Timothy, additional, Vineis, Paolo, additional, Porru, Stefano, additional, Buntinx, Frank, additional, Kellen, Eliane, additional, Zeegers, Maurice P, additional, Kumar, Rajiv, additional, Rudnai, Peter, additional, Gurzau, Eugene, additional, Koppova, Kvetoslava, additional, Mayordomo, Jose Ignacio, additional, Sanchez, Manuel, additional, Saez, Berta, additional, Lindblom, Annika, additional, de Verdier, Petra, additional, Steineck, Gunnar, additional, Mills, Gordon B, additional, Schned, Alan, additional, Chang, Shen-Chih, additional, Lin, Jie, additional, Chang, David W, additional, Hale, Katherine S, additional, Majewski, Tadeusz, additional, Grossman, H Barton, additional, Thorlacius, Steinunn, additional, Thorsteinsdottir, Unnur, additional, Aben, Katja K H, additional, Witjes, J Alfred, additional, Stefansson, Kari, additional, Amos, Christopher I, additional, Karagas, Margaret R, additional, and Gu, Jian, additional

Published
2009
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