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254. Quantitative structure-activity relationship (QSAR) study of polyhydroxyxanthones

Author

Ungwitayatorn, J., Pickert, M., and Frahm, A.W.

Abstract

In the present study 13C-chemical shift additivity rules are developed for polyhydroxyxanthones with antituberculotic activity against Mycobacterium tuberculosis. QSAR investigations are performed by correlating 13C-chemical shifts and calculated dipole moments of several 1,3-substituted polyhydroxyxanthones with their antituberculotic activity and by using the CoMFA approach as a threedimensional QSAR method.

Published
1997
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255. Dietary animal and plant protein intakes and their associations with obesity and cardio-metabolic indicators in European adolescents: the HELENA cross-sectional study

Author

Lin Y, Mouratidou T, Vereecken C, Kersting M, Bolca S, de Moraes AC, Cuenca García M, Moreno LA, González Gross M, Valtueña J, Labayen I, Grammatikaki E, Hallstrom L, Leclercq C, Ferrari M, Gottrand F, Beghin L, Manios Y, Ottevaere C, Van Oyen H, Molnar D, Kafatos A, Widhalm K, Gómez Martinez S, Prieto LE, De Henauw S, Huybrechts I, Gilbert C, Libersa C, Sánchez J, Sjöstrom M, Molnár D, Dallongeville J, Hall G, Maes L, Scalfi L, Meléndez P, Fleta J, Casajús JA, Rodríguez G, Tomás C, Mesana MI, Vicente Rodríguez G, Villarroya A, Gil CM, Ara I, Revenga J, Lachen C, Fernández Alvira J, Bueno G, Lázaro A, Bueno O, León JF, Garagorri JM, Bueno M, Rey López JP, Iglesia I, Velasco P, Bel Serrat S, Gracia Marco L, Jiménez Pavón D, Marcos A, Wärnberg J, Nova E, Gómez Martínez S, Ligia Díaz E, Romeo J, Veses A, Angeles Puertollano M, Zapatera B, Pozo T, Iliescu C, Von Berlepsch J, Sichert Hellert W, Koeppen E, Erhardt E, Csernus K, Török K, Bokor S, Angster, Nagy E, Kovács O, Répasi J, Codrington C, Plada M, Papadaki A, Sarri K, Viskadourou A, Hatzis C, Kiriakakis M, Tsibinos G, Vardavas C, Sbokos M, Protoyeraki E, Fasoulaki M, Stehle P, Pietrzik K, Breidenassel C, Spinneker A, Al Tahan J, Segoviano M, Berchtold A, Bierschbach C, Blatzheim E, Schuch A, Pickert P, Castillo MJ, Gutiérrez A, Ortega FB, Ruiz JR, Artero EG, España V, Chillón P, Sánchez Muñoz C, Cuenca M, Arcella D, Azzini E, Barrison E, Bevilacqua N, Buonocore P, Catasta G, Censi L, Ciarapica D, D'Acapito P, Galfo M, le Donne C, Maiani G, Mauro B, Mistura L, Pasquali A, Piccinelli R, Polito A, Spada R, Sette S, Zaccaria M, Montagnese C, De Bourdeaudhuij I, De Vriendt T, Matthys C, de Maeyer M, Phillipp K, Dietrich S, Kubelka B, Boriss Riedl M, Bouloubasi Z, Louisa Cook T, Eleutheriou S, Consta O, Moschonis G, Katsaroli I, Kraniou G, Papoutsou S, Keke D, Petraki I, Bellou E, Tanagra S, Kallianoti K, Argyropoulou D, Kondaki K, Tsikrika S, Karaiskos C, Meirhaeghe A, Sjöström M, Ruiz J, Hagströmer M, Hallström L, Patterson E, Kwak L, Rizzo N, Hurtig Wennlöf A, Sánchez Molero J, Picó E, Navarro M, Viadel B, Carreres JE, Merino G, Sanjuán R, Lorente M, Sánchez MJ, Castelló S, Thomas S, Allchurch E, Burguess P, Astrom A, Sverkén A, Broberg A, Masson A, Lehoux C, Brabant P, Pate P, Fontaine L, Sebok A, Kuti T, Hegyi A, Maldonado C, Llorente A, Cárnicas Serrano SL, García E, von Fircks H, Lilja Hallberg M, Messerer M, Larsson M, Fredriksson H, Adamsson V, Börjesson I, Fernández L, Smillie L, Wills J, Albers U, Pedrero R, Meléndez A, Benito PJ, Cañada D, Urzanqui A, Ortiz JC, Fuentes F, Gómez Lorente JJ, Mardía Torres R, Navarro P., VITAGLIONE, PAOLA, Lin, Y, Mouratidou, T, Vereecken, C, Kersting, M, Bolca, S, de Moraes, Ac, Cuenca García, M, Moreno, La, González Gross, M, Valtueña, J, Labayen, I, Grammatikaki, E, Hallstrom, L, Leclercq, C, Ferrari, M, Gottrand, F, Beghin, L, Manios, Y, Ottevaere, C, Van Oyen, H, Molnar, D, Kafatos, A, Widhalm, K, Gómez Martinez, S, Prieto, Le, De Henauw, S, Huybrechts, I, Gilbert, C, Libersa, C, Sánchez, J, Sjöstrom, M, Molnár, D, Dallongeville, J, Hall, G, Maes, L, Scalfi, L, Meléndez, P, Fleta, J, Casajús, Ja, Rodríguez, G, Tomás, C, Mesana, Mi, Vicente Rodríguez, G, Villarroya, A, Gil, Cm, Ara, I, Revenga, J, Lachen, C, Fernández Alvira, J, Bueno, G, Lázaro, A, Bueno, O, León, Jf, Garagorri, Jm, Bueno, M, Rey López, Jp, Iglesia, I, Velasco, P, Bel Serrat, S, Gracia Marco, L, Jiménez Pavón, D, Marcos, A, Wärnberg, J, Nova, E, Gómez Martínez, S, Ligia Díaz, E, Romeo, J, Veses, A, Angeles Puertollano, M, Zapatera, B, Pozo, T, Iliescu, C, Von Berlepsch, J, Sichert Hellert, W, Koeppen, E, Erhardt, E, Csernus, K, Török, K, Bokor, S, Angster, Nagy, E, Kovács, O, Répasi, J, Codrington, C, Plada, M, Papadaki, A, Sarri, K, Viskadourou, A, Hatzis, C, Kiriakakis, M, Tsibinos, G, Vardavas, C, Sbokos, M, Protoyeraki, E, Fasoulaki, M, Stehle, P, Pietrzik, K, Breidenassel, C, Spinneker, A, Al Tahan, J, Segoviano, M, Berchtold, A, Bierschbach, C, Blatzheim, E, Schuch, A, Pickert, P, Castillo, Mj, Gutiérrez, A, Ortega, Fb, Ruiz, Jr, Artero, Eg, España, V, Chillón, P, Sánchez Muñoz, C, Cuenca, M, Arcella, D, Azzini, E, Barrison, E, Bevilacqua, N, Buonocore, P, Catasta, G, Censi, L, Ciarapica, D, D'Acapito, P, Galfo, M, le Donne, C, Maiani, G, Mauro, B, Mistura, L, Pasquali, A, Piccinelli, R, Polito, A, Spada, R, Sette, S, Zaccaria, M, Vitaglione, Paola, Montagnese, C, De Bourdeaudhuij, I, De Vriendt, T, Matthys, C, de Maeyer, M, Phillipp, K, Dietrich, S, Kubelka, B, Boriss Riedl, M, Bouloubasi, Z, Louisa Cook, T, Eleutheriou, S, Consta, O, Moschonis, G, Katsaroli, I, Kraniou, G, Papoutsou, S, Keke, D, Petraki, I, Bellou, E, Tanagra, S, Kallianoti, K, Argyropoulou, D, Kondaki, K, Tsikrika, S, Karaiskos, C, Meirhaeghe, A, Sjöström, M, Ruiz, J, Hagströmer, M, Hallström, L, Patterson, E, Kwak, L, Rizzo, N, Hurtig Wennlöf, A, Sánchez Molero, J, Picó, E, Navarro, M, Viadel, B, Carreres, Je, Merino, G, Sanjuán, R, Lorente, M, Sánchez, Mj, Castelló, S, Thomas, S, Allchurch, E, Burguess, P, Astrom, A, Sverkén, A, Broberg, A, Masson, A, Lehoux, C, Brabant, P, Pate, P, Fontaine, L, Sebok, A, Kuti, T, Hegyi, A, Maldonado, C, Llorente, A, Cárnicas Serrano, Sl, García, E, von Fircks, H, Lilja Hallberg, M, Messerer, M, Larsson, M, Fredriksson, H, Adamsson, V, Börjesson, I, Fernández, L, Smillie, L, Wills, J, Albers, U, Pedrero, R, Meléndez, A, Benito, Pj, Cañada, D, Urzanqui, A, Ortiz, Jc, Fuentes, F, Gómez Lorente, Jj, Mardía Torres, R, Navarro, P., European Commission, Swedish Council for Working Life and Social Research, Ministerio de Educación (España), Ministerio de Sanidad y Consumo (España), Ministerio de Ciencia e Innovación (España), Fundação de Amparo à Pesquisa do Estado de São Paulo, Conselho Nacional de Desenvolvimento Científico e Tecnológico (Brasil), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Brasil), and Matthys, Christophe

Subjects
Male, NUTRITION AND DIETETICS, CHILDHOOD, Medicine (miscellaneous), Overweight, Body fat percentage, Body Mass Index, clinical-trial, fat, Medicine and Health Sciences, HELENA cross-sectional study, dietary proteins, adolescence, Child, treat obesity, Plant Proteins, 2. Zero hunger, Nutrition and Dietetics, Anthropometry, Age Factors, Lipids, Diet Records, 3. Good health, Europe, Plant protein, HELENA study, Female, Dietary Proteins, medicine.symptom, Underweight, Life Sciences & Biomedicine, energy, medicine.medical_specialty, Meat, Adolescent, Clinical nutrition, Sex Factors, Thinness, children, Internal medicine, Environmental health, medicine, body-weight, Animals, Humans, overweight, Obesity, Exercise, body composition, Science & Technology, Nutrition & Dietetics, business.industry, MEDICINE, Research, biomarkers, medicine.disease, protein intake, disease risk, Diet, chilhood, Endocrinology, Cross-Sectional Studies, Nutrition Assessment, adolescence, business, Energy Intake, nutritional-status, Body mass index
Abstract

Lin, Y. et al., [Background] Previous studies suggest that dietary protein might play a beneficial role in combating obesity and its related chronic diseases. Total, animal and plant protein intakes and their associations with anthropometry and serum biomarkers in European adolescents using one standardised methodology across European countries are not well documented., [Objectives] To evaluate total, animal and plant protein intakes in European adolescents stratified by gender and age, and to investigate their associations with cardio-metabolic indicators (anthropometry and biomarkers)., [Methods] The current analysis included 1804 randomly selected adolescents participating in the HELENA study (conducted in 2006–2007) aged 12.5-17.5 y (47% males) who completed two non-consecutive computerised 24-h dietary recalls. Associations between animal and plant protein intakes, and anthropometry and serum biomarkers were examined with General linear Model multivariate analysis., [Results] Average total protein intake exceeded the recommendations of World Health Organization and European Food Safety Authority. Mean total protein intake was 96 g/d (59% derived from animal protein). Total, animal and plant protein intakes (g/d) were significantly lower in females than in males and total and plant protein intakes were lower in younger participants (12.5-14.9 y). Protein intake was significantly lower in underweight subjects and higher in obese ones; the direction of the relationship was reversed after adjustments for body weight (g/(kg.d)). The inverse association of plant protein intakes was stronger with BMI z-score and body fat percentage (BF%) compared to animal protein intakes. Additionally, BMI and BF% were positively associated with energy percentage of animal protein., [Conclusions] This sample of European adolescents appeared to have adequate total protein intake. Our findings suggest that plant protein intakes may play a role in preventing obesity among European adolescents. Further longitudinal studies are needed to investigate the potential beneficial effects observed in this study in the prevention of obesity and related chronic diseases., The HELENA-study took place with the financial support of the European Community Sixth RTD Framework Programme. This work was also partially supported by the European Union in the framework of the Public Health Programme, the Swedish Council for Working Life and Social Research (FAS), the Spanish Ministry of Education, and the Spanish Ministry of Health, Maternal, Child Health and Development Network and the Spanish Ministry of Science and Innovation AGL2007-29784-E. The content of this paper reflect only the authors' views and the rest of HELENA-study members and the European Community is not liable for any use that may be made of the information contained therein. Augusto César F. de Moraes is in receipt of a PhD scholarship from the São Paulo State Research Foundation (FAPESP: proc. 2011/11137-1 and 2011/20662-2) and Postdoctoral Research Fellow scholarship from National Counsel of Technological and Scientific Development (CNPq: proc. 313772/2014-2); Luis A. Moreno was given scholarship of Visiting Professor from Brazilian government by Science without Borders Program by CNPq and CAPES (Coordination of Improvement of Higher Education Personnel) (proc. 007/2012). The GENUD Research Group co-financed by the European Regional Development Fund (MICINN-FEDER). Many thanks to Petra Pickert, Anke Carstensen and Rosa Maria Torres for their contribution to laboratory work.

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263. Plasmaeiweisskörperregulation

Author

Pickert, Heinz

Abstract

Zusammenfassung Die Plasmaeiweißveränderungen beim Bauchtyphus unterliegen demnach einer gesetzmäßigen Steuerung. Betrachtet man die Gesamtumstellung des Organismus, die ihren Wendepunkt am Ende der Fieberperiode hat, so ordnen sich auch unsere Untersuchungsergebnisse dem ein. In diesem Punkt erreichen die verminderte Blutmenge, das Absinken der zirkulierenden Eiweißmengen, die Zunahme des Globulins und der Euglobulinfraktion ihre stärkste Ausprägung. Diesem Maximum streben die Werte zu, um nachher sich stets zur Norm zurück zu bilden.

Published
1948
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264. Impact of physical activity and cardiovascular fitness on total homocysteine concentrations in European adolescents: The HELENA study

Author

Benser, J., Valtueña, J., Ruiz, J. R., Mielgo-Ayuso, J., Breidenassel, C., Vicente-Rodriguez, G., Ferrari, M., Widhalm, K., Manios, Y., Sjöström, M., Molnar, D., Gómez-Martínez, S., Kafatos, A., Palacios, G., Moreno, L. A., Castillo, M. J., Stehle, P., González-Gross, M., Helena Study Group, Gottrand, F., Henauw, S., Gilbert, C., Libersa, C., Sánchez, J., Kersting, M., Sjöstrom, M., Molnár, D., Dallongeville, J., Hall, G., Maes, L., Scalfi, L., Meléndez, P., Fleta, J., Casajús, J. A., Rodríguez, G., Tomás, C., Mesana, M. I., Vicente-Rodríguez, G., Villarroya, A., Gil, C. M., Ara, I., Revenga, J., Lachen, C., Alvira, J. F., Bueno, G., Lázaro, A., Bueno, O., León, J. F., Garagorri, J. M., Bueno, M., López, J. P. R., Iglesia, I., Velasco, P., Bel, S., Marcos, A., Wärnberg, J., Nova, E., Díaz, E. L., Romeo, J., Veses, A., Puertollano, M. A., Zapatera, B., Pozo, T., Beghin, L., Iliescu, C., Berlepsch, J., Sichert-Hellert, W., Koeppen, E., Erhardt, E., Csernus, K., Török, K., Bokor, S., Angster, Nagy, E., Kovács, O., Répasi, J., Codrington, C., Plada, M., Papadaki, A., Sarri, K., Viskadourou, A., Hatzis, C., Kiriakakis, M., Tsibinos, G., Sbokos, C. V. M., Protoyeraki, E., Fasoulaki, M., Pietrzik, K., Spinneker, A., Al-Tahan, J., Segoviano, M., Berchtold, A., Bierschbach, C., Blatzheim, E., Schuch, A., Pickert, P., Garzón, M. J. C., Sáinz, Á G., Porcel, F. B. O., Artero, E. G., Romero, V. E., Pavón, D. J., Muñoz, C. S., Soto, V., Chillón, P., Heredia, J. M., Virginia A Aparicio, Baena, P., Cardia, C. M., Carbonell, A., Arcella, D., Azzini, E., Barrison, E., Bevilacqua, N., Buonocore, P., Catasta, G., Censi, L., Ciarapica, D., D’acapito, P., Galfo, M., Le Donne, C., Leclercq, C., Maiani, G., Mauro, B., Mistura, L., Pasquali, A., Piccinelli, R., Polito, A., Spada, R., Sette, S., Zaccaria, M., Vitaglione, P., Montagnese, C., Bourdeaudhuij, I., Vriendt, T., Matthys, C., Vereecken, C., Maeyer, M., Ottevaere, C., Huybrechts, I., Dietrich, S., Grammatikaki, E., Bouloubasi, Z., Cook, T. L., Eleutheriou, S., Consta, O., Moschonis, G., Katsaroli, I., Kraniou, G., Papoutsou, S., Keke, D., Petraki, I., Bellou, E., Tanagra, S., Kallianoti, K., Argyropoulou, D., Kondaki, K., Tsikrika, S., Karaiskos, C., Meirhaeghe, A., Bergman, P., Hagströmer, M., Hallström, L., Hallberg, M., Poortvliet, E., Rizzo, N., Beckman, L., Wennlöf, A. H., Patterson, E., Kwak, L., Cernerud, L., Tillgren, P., Sörensen, S., Sánchez-Molero, J., Picó, E., Navarro, M., Viadel, B., Carreres, J. E., Merino, G., Sanjuán, R., Lorente, M., Sánchez, M. J., Castelló, S., Thomas, S., Allchurch, E., Burguess, P., Astrom, A., Sverkén, A., Broberg, A., Masson, A., Lehoux, C., Brabant, P., Pate, P., Fontaine, L., Sebok, A., Kuti, T., Hegyi, A., Maldonado, C., Llorente, A., García, E., Fircks, H., Hallberg, M. L., Messerer, M., Larsson, M., Fredriksson, H., Adamsson, V., Börjesson, I., Fernández, L., Smillie, L., Wills, J., Pedrero-Chamizo, R., Meléndez, A., Benito, P. J., Lorente, J. J. G., Cañada, D., Urzanqui, A., Ortiz, J. C., Fuentes, F., Jiménez-Pavón, D., Albers, U., Ayuso, J. M., Torres, R. M., and Navarro, P.

265. Promoting healthy European lifestyle by exercise and nutrition in adolescents: The HELENA study,Promocionado un estilo de vida saludable en los adolescentes europeos mediante el ejercicio y la nutrición El proyecto HELENA

Author

Moreno Aznar, L. A., González-Gross, M., Marcos, A., Jiménez-Pavón, D., Sánchez, M. J., Mesana, M. I., Gómez, S., Vicente-Rodríguez, G., Diaz, L. E., Castillo, M. J., Gottrand, F., Henauw, S., Gilbert, C., Kafatos, A., Libersa, C., Sánchez, J., Kersting, M., Sjöstrom, M., Molnánar, D., Dallongeville, J., Hall, G., Maes, L., Scalfi, L., Meléndez, P., Fleta, J., Casajús, J. A., Rodríguez, G., Tomás, C., Villaroya, A., Gil, C. M., Ara, I., Revenga, J., Lachen, C., Alvira, J. F., Bueno, G., Lázaro, A., Bueno, O., León, J. F., Garagorri, J. M., Bueno, M., Rey López, J. P., Iglesia, I., Velasco, P., Bel, S., Wärnberg, J., Nova, E., Esperanza Díaz, L., Romeo, J., Prato, A., Linde, J., Beghin, L., Iliescu, C., Berlepsch, J., Sichert-Hellert, W., Koeppen, E., Erhardt, E., Csernus, K., Török, K., Bokor, S., Angster, Nagy, E., Kováes, O., Répasi, J., Codrington, C., Papadaki, A., Plada, M., Sarri, K., Moschandreas, J., Hatzis, C., Linardakis, M., Vardavas, C., Bervanaki, F., Viskadourou, A., Stehle, P., Pietrzik, K., Breidenassel, C., Spinneker, A., Al-Tahan, J., Segoviano, M., Bierschbach, C., Blatzheim, E., Schuch, A., Pickert, P., Bülow, P., Gutiérrez Sáinz, Á, Ruiz, J. R., Ortega Porcel, F. B., Enrique G. Artero, Carreño Gálvez, F., España Romero, V., Sánchez Muñoz, C., Arcella, D., Catasta, G., Censi, L., Ciarapica, D., Ferrari, M., Le Donne, C., Leclerq, C., and Magri, L.

266. Promoting healthy European lifestyle by exercise and nutrition in adolescents: The HELENA study | Promocionado un estilo de vida saludable en los adolescentes europeos mediante el ejercicio y la nutrición El proyecto HELENA

Author

Moreno Aznar, L. A., González-Gross, M., Marcos, A., Jiménez-Pavón, D., Sánchez, M. J., Mesana, M. I., Gómez, S., Vicente-Rodríguez, G., Diaz, L. E., Castillo, M. J., Gottrand, F., Henauw, S., Gilbert, C., Kafatos, A., Libersa, C., Sánchez, J., Kersting, M., Sjöstrom, M., Molnánar, D., Dallongeville, J., Hall, G., Maes, L., Scalfi, L., Meléndez, P., Fleta, J., Casajús, J. A., Rodríguez, G., Tomás, C., Villaroya, A., Gil, C. M., Ara, I., Revenga, J., Lachen, C., Alvira, J. F., Bueno, G., Lázaro, A., Bueno, O., León, J. F., Garagorri, J. M., Bueno, M., Rey López, J. P., Iglesia, I., Velasco, P., Bel, S., Wärnberg, J., Nova, E., Esperanza Díaz, L., Romeo, J., Prato, A., Linde, J., Beghin, L., Iliescu, C., Berlepsch, J., Sichert-Hellert, W., Koeppen, E., Erhardt, E., Csernus, K., Török, K., Bokor, S., Angster, Nagy, E., Kováes, O., Répasi, J., Codrington, C., Papadaki, A., Plada, M., Sarri, K., Moschandreas, J., Hatzis, C., Linardakis, M., Vardavas, C., Bervanaki, F., Viskadourou, A., Stehle, P., Pietrzik, K., Breidenassel, C., Spinneker, A., Al-Tahan, J., Segoviano, M., Bierschbach, C., Blatzheim, E., Schuch, A., Pickert, P., Bülow, P., Gutiérrez Sáinz, Á, Ruiz, J. R., Ortega Porcel, F. B., García Artero, E., Carreño Gálvez, F., España Romero, V., Sánchez Muñoz, C., Arcella, D., Catasta, G., Censi, L., Donatella Ciarapica, Ferrari, M., Le Donne, C., Leclerq, C., and Magri, L.

270. Environmentally dependent sensitive periods for avian vocal learning

Author

Kroodsma, Donald E. and Pickert, Roberta

Abstract

Experience during brief periods of development can exert a profound influence on later life1. Among songbirds, experimental evidence for enhanced vocal learning during a relatively brief period early in life is well documented2,3. The timing of vocal learning with respect to dispersal is fundamental to our understanding of many population processes, yet the significance of the sensitive period remains unclear. We report here that in our study of the marsh wren (Cistothorus palustris), a North American songbird, we found that the sensitive period for song learning is not rigidly programmed with respect to dispersal and/or migration; two environmental factors, the photoperiod and the amount of adult song heard during the hatching year, influence the nature of the sensitive period during the hatching year, the ability to learn further the next spring, and the relative dates at which young males develop their adult songs.

Published
1980
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274. Nutritional Wheat Amylase-Trypsin Inhibitors Promote Intestinal Inflammation via Activation of Myeloid Cells.

Author

Zevallos, Victor F., Raker, Verena, Tenzer, Stefan, Jimenez-Calvente, Carolina, Ashfaq-Khan, Muhammad, Rüssel, Nina, Pickert, Geethanjali, Schild, Hansjörg, Steinbrink, Kerstin, and Schuppan, Detlef

Abstract

Background & Aims Wheat amylase-trypsin inhibitors (ATIs) are nutritional activators of innate immunity, via activation of the toll-like receptor 4 (TLR4) on myeloid cells. We aimed to characterize the biologic activity of ATIs in various foods and their effect on intestinal inflammation. Methods We selected 38 different gluten-containing and gluten-free products, either unprocessed (such as wheat, rye, barley, quinoa, amaranth, soya, lentils, and rice) or processed (such as pizza, pasta, bread, and biscuits). ATIs were extracted and their biological activities determined in TLR4-responsive mouse and human cell lines. Effects of oral ATIs on intestinal inflammation were determined in healthy C57BL/6 mice on a gluten-free or ATI-free diet and in mice given low-level polyinosinic:polycytidylic acid or dextran sodium sulfate to induce colitis. Parameters of innate and adaptive immune activation were determined in duodenum, ileum, colon, and mesenteric lymph nodes. Results Modern gluten-containing staples had levels of TLR4-activating ATIs that were as much as 100-fold higher than in most gluten-free foods. Processed or baked foods retained ATI bioactivity. Most older wheat variants (such as Emmer or Einkorn) had lower bioactivity than modern (hexaploid) wheat. ATI species CM3 and 0.19 were the most prevalent activators of TLR4 in modern wheat and were highly resistant to intestinal proteolysis. Their ingestion induced modest intestinal myeloid cell infiltration and activation, and release of inflammatory mediators—mostly in the colon, then in the ileum, and then in the duodenum. Dendritic cells became prominently activated in mesenteric lymph nodes. Concentrations of ATIs found in a normal daily gluten-containing diet increased low-level intestinal inflammation. Conclusions Gluten-containing cereals have by far the highest concentrations of ATIs that activate TLR4. Orally ingested ATIs are largely resistant to proteases and heat, and increase intestinal inflammation by activating gut and mesenteric lymph node myeloid cells. [ABSTRACT FROM AUTHOR]

Published
2017
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275. Lived Experience of Stroke Survivors Returning to Work.

Author

Bondoc, Salvador, Campo, Chelsea, O'Donnell Pickert, Kathleen, and Sirois, Kristyn

Subjects
EMPLOYMENT reentry, INTERVIEWING, PHENOMENOLOGY, RESEARCH methodology, MOTIVATION (Psychology), SELF-perception, JUDGMENT sampling, THEMATIC analysis, PATIENTS' attitudes, STROKE patients, OCCUPATIONAL adaptation, ATTITUDES toward illness, PSYCHOLOGY
Abstract

This qualitative study explores the lived experience of stroke survivors returning to work after rehabilitation. Common themes of their lived experience point to the need to address return to work early in the rehab process and foster a sense of self-efficacy about returning to work. [ABSTRACT FROM AUTHOR]

Published
2016
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279. BARs (B-cell receptor antigens for reverse targeting): A Novel and Ultimately Specific Treatment Concept for B-Cell Neoplasms

Author

Pfreundschuh, Michael, Thurner, Lorenz, Barth, Stefan, Pickert, Diana, Fadle, Natalie, Kemele, Maria, Regitz, Evi, Neumann, Frank, Nachreiner, Thomas, and Preuss, Klaus-Dieter

Abstract

Introduction:The major task of a B-cell receptor is the binding and internalization of its antigenic target, and its processing for antigen presentation to T-cells. Chronic antigenic stimulation has been discussed to play a role in the pathogenesis of malignant B-cell lymphomas. We therefore systematically searched for the antigenic targets of BCRs from various B-cell neoplasms.

Published
2015
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286. Advanced Extramedullary Hematopoiesis In a Transplanted Liver Graft As Initial Presentation Of Primary Myelofibrosis

Author

Yacoub, Abdulraheem, Pickert, Coralie, and Cui, Wei

Abstract

Primary myelofibrosis (PMF) is one of the BCR-ABL-negative myeloproliferative neoplasms. The hallmarks of PMF include increased bone marrow (BM) fibrosis, megakaryocytic hyperplasia with hyperchromatic nuclei and abnormal lobation, leukoerythroblastosis, cytopenias, extramedullary hematopoiesis (EMH), and constitutional symptoms that can be debilitating. PMF is associated with the constitutive mobilization of CD34+ cells into the peripheral blood which characteristically occurs in the more clinically advanced phases of the disease. This dysregulation of hematopoietic stem cell (HSC) trafficking likely ultimately leads to the seeding of extramedullary sites with primitive hematopoietic capacity, resulting in EMH within the spleen and liver as well as a variety of other organs. We present a first report of a unique presentation of PMF in a liver transplant-recipient patient as EMH in the transplanted liver graft.

Published
2013
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288. Sheikh Jarrah residents organize in the face of mass house evictions.

Author

Pickert, Jeff

Abstract

The article focuses on the issue of mass house evictions in Sheikh Jarrah, Jerusalem. The Israeli court has considered the land to which the Sheikh Jarrah neighborhood as disputed even if the houses were built through the United Nations agency for Palestine refugees (UNRWA) and the Jordanian government. The al-Ghawe and Hanun families occupying Sheikh Jarrah reportedly worries of unjust and cruel evictions like what the al-Kurd family experienced in November 2008 despite wide public support.

Published
2009

289. ChemInform Abstract: Substituted Xanthones as Antimycobacterial Agents. Part 1. Synthesis and Assignment of 1H/13C NMR Chemical Shifts.

Author

PICKERT, M. and FRAHM, A. W.

Abstract

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Published
1998
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292. ChemInform Abstract: Substituted Xanthones as Antimycobacterial Agents. Part 2. Antimycobacterial Activity.

Author

PICKERT, M., SCHAPER, K. J., and FRAHM, A. W.

Abstract

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Published
1998
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295. HYPERSENSITIVITY TO IMMUNE SERUM GLOBULIN

Author

Pickert, Edward

Abstract

TO THE EDITOR:— The clinical note in The Journal, Sept. 26, 1959, page 415, is a case report entitled "Hypersensitivity to Immune Serum Globulin." The publication of this seems unfortunate to me, since both diagnosis and treatment are open to question. The inaccuracies which it contains could lead to disaster in circumstances of a similar nature. The concept of spontaneous hypersensitivity to human immune serum globulin is hardly borne out by any of the evidence or comments printed. The fact that both parents had a strong allergic history scarcely gives any additional credibility to this diagnosis, in a 15-week-old child who has yet to manifest one symptom of an allergic nature despite the fact that it has met and apparently overcome successfully innumerable antigens.Even the comments of the consultant which are included contain rather misleading statements; e. g., speaking of the possibility of allergy, "The mechanism is of some

Published
1960
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296. Correlates of ideal cardiovascular health in European adolescents: The HELENA study

Author

P. Henriksson, H. Henriksson, I. Labayen, I. Huybrechts, L. Gracia-Marco, F.B. Ortega, V. España-Romero, Y. Manios, M. González-Gross, A. Marcos, L.A. Moreno, Á. Gutiérrez, J.R. Ruiz, F. Gottrand, S. De Henauw, C. Gilbert, A. Kafatos, C. Libersa, J. Sánchez, M. Kersting, M. Sjöstrom, D. Molnár, J. Dallongeville, G. Hall, L. Maes, L. Scalfi, P. Meléndez, J. Fleta, J.A. Casajús, G. Rodríguez, C. Tomás, M.I. Mesana, G. Vicente-Rodríguez, A. Villarroya, C.M. Gil, I. Ara, J. Revenga, C. Lachen, J.F. Alvira, G. Bueno, A. Lázaro, O. Bueno, J.F. León, J.Ma Garagorri, M. Bueno, J.P. Rey López, I. Iglesia, P. Velasco, S. Bel, J. Wärnberg, E. Nova, S. Gómez-Martinez, L.E. Díaz, J. Romeo, A. Veses, M.A. Puertollano, B. Zapatera, T. Pozo, L. Beghin, C. Iliescu, J. Von Berlepsch, W. Sichert-Hellert, E. Koeppen, D. Molnar, E. Erhardt, K. Csernus, K. Török, S. Bokor, null Angster, E. Nagy, O. Kovács, J. Repásy, C. Codrington, M. Plada, A. Papadaki, K. Sarri, A. Viskadourou, C. Hatzis, M. Kiriakakis, G. Tsibinos, C. Vardavas, M. Sbokos, E. Protoyeraki, M. Fasoulaki, P. Stehle, K. Pietrzik, C. Breidenassel, A. Spinneker, J. Al-Tahan, M. Segoviano, A. Berchtold, C. Bierschbach, E. Blatzheim, A. Schuch, P. Pickert, M.J. Castillo, E.G. Artero, D. Jiménez-Pavón, P. Chillón, D. Arcella, E. Azzini, E. Barrison, N. Bevilacqua, P. Buonocore, G. Catasta, L. Censi, D. Ciarapica, P. D'Acapito, M. Ferrari, M. Galfo, C. Le Donne, C. Leclercq, G. Maiani, B. Mauro, L. Mistura, A. Pasquali, R. Piccinelli, A. Polito, R. Spada, S. Sette, M. Zaccaria, P. Vitaglione, C. Montagnese, I. De Bourdeaudhuij, T. De Vriendt, C. Matthys, C. Vereecken, M. de Maeyer, C. Ottevaere, K. Widhalm, K. Phillipp, S. Dietrich, B. Kubelka, M. Boriss-Riedl, E. Grammatikaki, Z. Bouloubasi, T.L. Cook, S. Eleutheriou, O. Consta, G. Moschonis, I. Katsaroli, G. Kraniou, S. Papoutsou, D. Keke, I. Petraki, E. Bellou, S. Tanagra, K. Kallianoti, D. Argyropoulou, K. Kondaki, S. Tsikrika, C. Karaiskos, A. Meirhaeghe, P. Bergman, M. Hagströmer, L. Hallström, M. Hallberg, E. Poortvliet, N. Rizzo, L. Beckman, A.H. Wennlöf, E. Patterson, L. Kwak, L. Cernerud, P. Tillgren, S. Sörensen, J. Sánchez-Molero, E. Picó, M. Navarro, B. Viadel, J.E. Carreres, G. Merino, R. Sanjuán, M. Lorente, M.J. Sánchez, S. Castelló, S. Thomas, E. Allchurch, P. Burguess, A. Astrom, A. Sverkén, A. Broberg, A. Masson, C. Lehoux, P. Brabant, P. Pate, L. Fontaine, A. Sebok, T. Kuti, A. Hegyi, C. Maldonado, A. Llorente, E. García, H. von Fircks, M.L. Hallberg, M. Messerer, M. Larsson, H. Fredriksson, V. Adamsson, I. Börjesson, L. Fernández, L. Smillie, J. Wills, J. Valtueña, U. Albers, R. Pedrero, A. Meléndez, P.J. Benito, J. Calderón, J.J. Gómez Lorente, D. Cañada, A. Urzanqui, J. Carlos Ortiz, F. Fuentes, R. María Torres, P. Navarro, European Commission, Ministerio de Ciencia e Innovación (España), Ministerio de Sanidad (España), Universidad de Granada, Swedish Society of Medicine, Henriksson, P., Henriksson, H., Labayen, I., Huybrechts, I., Gracia-Marco, L., Ortega, F. B., España-Romero, V., Manios, Y., González-Gross, M., Marcos, A., Moreno, L. A., Gutiérrez, Ã ., Ruiz, J. R., Gottrand, F., De Henauw, S., Gilbert, C., Kafatos, A., Libersa, C., Sánchez, J., Kersting, M., Sjöstrom, M., Molnár, D., Dallongeville, J., Hall, G., Maes, L., Scalfi, L., Meléndez, P., Fleta, J., Casajús, J. A., Rodríguez, G., Tomás, C., Mesana, M. I., Vicente-Rodríguez, G., Villarroya, A., Gil, C. M., Ara, I., Revenga, J., Lachen, C., Alvira, J. F., Bueno, G., Lázaro, A., Bueno, O., León, J. F., Garagorri, J. M., Bueno, M., Rey López, J. P., Iglesia, I., Velasco, P., Bel, S., Wärnberg, J., Nova, E., Gómez-Martinez, S., Díaz, L. E., Romeo, J., Veses, A., Puertollano, M. A., Zapatera, B., Pozo, T., Beghin, L., Iliescu, C., Von Berlepsch, J., Sichert-Hellert, W., Koeppen, E., Molnar, D., Erhardt, E., Csernus, K., Török, K., Bokor, S., Angster, Null, Nagy, E., Kovács, O., Repásy, J., Codrington, C., Plada, M., Papadaki, A., Sarri, K., Viskadourou, A., Hatzis, C., Kiriakakis, M., Tsibinos, G., Vardavas, C., Sbokos, M., Protoyeraki, E., Fasoulaki, M., Stehle, P., Pietrzik, K., Breidenassel, C., Spinneker, A., Al-Tahan, J., Segoviano, M., Berchtold, A., Bierschbach, C., Blatzheim, E., Schuch, A., Pickert, P., Castillo, M. J., Artero, E. G., Jiménez-Pavón, D., Chillón, P., Arcella, D., Azzini, E., Barrison, E., Bevilacqua, N., Buonocore, P., Catasta, G., Censi, L., Ciarapica, D., D'Acapito, P., Ferrari, M., Galfo, M., Le Donne, C., Leclercq, C., Maiani, G., Mauro, B., Mistura, L., Pasquali, A., Piccinelli, R., Polito, A., Spada, R., Sette, S., Zaccaria, M., Vitaglione, P., Montagnese, C., De Bourdeaudhuij, I., De Vriendt, T., Matthys, C., Vereecken, C., de Maeyer, M., Ottevaere, C., Widhalm, K., Phillipp, K., Dietrich, S., Kubelka, B., Boriss-Riedl, M., Grammatikaki, E., Bouloubasi, Z., Cook, T. L., Eleutheriou, S., Consta, O., Moschonis, G., Katsaroli, I., Kraniou, G., Papoutsou, S., Keke, D., Petraki, I., Bellou, E., Tanagra, S., Kallianoti, K., Argyropoulou, D., Kondaki, K., Tsikrika, S., Karaiskos, C., Meirhaeghe, A., Bergman, P., Hagströmer, M., Hallström, L., Hallberg, M., Poortvliet, E., Rizzo, N., Beckman, L., Wennlöf, A. H., Patterson, E., Kwak, L., Cernerud, L., Tillgren, P., Sörensen, S., Sánchez-Molero, J., Picó, E., Navarro, M., Viadel, B., Carreres, J. E., Merino, G., Sanjuán, R., Lorente, M., Sánchez, M. J., Castelló, S., Thomas, S., Allchurch, E., Burguess, P., Astrom, A., Sverkén, A., Broberg, A., Masson, A., Lehoux, C., Brabant, P., Pate, P., Fontaine, L., Sebok, A., Kuti, T., Hegyi, A., Maldonado, C., Llorente, A., García, E., von Fircks, H., Hallberg, M. L., Messerer, M., Larsson, M., Fredriksson, H., Adamsson, V., Börjesson, I., Fernández, L., Smillie, L., Wills, J., Valtueña, J., Albers, U., Pedrero, R., Meléndez, A., Benito, P. J., Calderón, J., Gómez Lorente, J. J., Cañada, D., Urzanqui, A., Carlos Ortiz, J., Fuentes, F., María Torres, R., and Navarro, P.

Subjects
Blood Glucose, Male, Health Knowledge, Attitudes, Practice, Adolescent, Epidemiology, Health Status, Endocrinology, Diabetes and Metabolism, Health Behavior, Ideal Body Weight, Medicine (miscellaneous), Blood Pressure, Health Promotion, 030204 cardiovascular system & hematology, Risk Assessment, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Nutrition and Dietetic, Health Status Indicators, Humans, Socioeconomic statu, Healthy Lifestyle, 030212 general & internal medicine, Exercise, Public health, Nutrition and Dietetics, Prevention, Smoking, Age Factors, Protective Factors, Cardiovascular health, Europe, Primary Prevention, Cholesterol, Cross-Sectional Studies, Adolescent Behavior, Cardiovascular Diseases, Television, Female, Risk factor, Diet, Healthy, Cardiology and Cardiovascular Medicine, Biomarkers
Abstract

On behalf of the HELENA Study Group., [Background and aims]: The ideal cardiovascular health (iCVH) construct consists of 4 health behaviors (smoking status, body mass index, physical activity and diet) and 3 health factors (total cholesterol, blood pressure and fasting glucose). A greater number of iCVH components in adolescence are related to better cardiovascular health, but little is known about the correlates of iCVH in adolescents. Thus, the aim of the study was to examine correlates of iCVH in European adolescents., [Methods and results]: The study comprised 637 European adolescents with complete iCVH data. Participants were part of the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) study, a cross-sectional, multicenter study conducted in 9 different European countries. Correlates investigated were sex and age, family affluence scale, maternal education, geographic location, sleep time, television viewing, duration of pregnancy, birth weight and breastfeeding. Younger adolescents, those whose mothers had medium/high education or those who watched television less than 2 h per day had a greater number of iCVH components compared to those who were older, had a mother with low education or watched television 2 h or more daily (P ≤ 0.01)., [Conclusion]: Since in our study older adolescents had worse iCVH than younger adolescents, early promotion of cardiovascular health may be important. Future studies may also investigate the usefulness of limiting television viewing to promote iCVH. Finally, since adolescents of mothers with low education had poorer iCVH, it may be of special interest to tailor public health promotion to adolescents from families with low socioeconomic status., The HELENA project was supported by the European Community Sixth RTD Framework Programme (contract FOOD-CT-2005-007034). The data for this study was gathered under the aegis of the HELENA project, and further analysis was additionally supported by the Spanish Ministry of Economy and Competitiveness (grants RYC-2010-05957 and RYC-2011-09011), the Spanish Ministry of Health: Maternal, Child Health and Development Network (grant RD16/0022), the Fondo Europeo de Desarrollo Regional (MICINN-FEDER) and by the University of Granada, Plan Propio de Investigación 2016, Excellence actions: Units of Excellence; Unit of Excellence on Exercise and Health (UCEES). Pontus Henriksson was supported by a grant from Henning and Johan Throne-Holst Foundation. Hanna Henriksson was supported by grants from the Swedish Society of Medicine and the County Council of Östergötland, Sweden. Dr. Gracia-Marco acknowledges “Programa de Captación de Talento - UGR Fellows” as part of “Plan Propio” of the University of Granada (Spain).

Published
2018

297. Inflammation in metabolically healthy and metabolically abnormal adolescents: The HELENA study

Author

E.M. González-Gil, C. Cadenas-Sanchez, J. Santabárbara, G. Bueno-Lozano, I. Iglesia, M. González-Gross, D. Molnar, F. Gottrand, S. De Henauw, A. Kafatos, K. Widhalm, Y. Manios, A. Siani, F. Amaro-Gahete, A.I. Rupérez, D. Cañada, L. Censi, M. Kersting, J. Dallongeville, A. Marcos, F.B. Ortega, L.A. Moreno, C. Gilbert, C. Libersa, S. Castelló, M. Sjöstrom, D. Molnár, G. Hall, L. Maes, L. Scalfi, P. Meléndez, J. Fleta, J.A. Casajús, G. Rodríguez, C. Tomás, M.I. Mesana, G. Vicente-Rodríguez, A. Villarroya, C.M. Gil, I. Ara, J.F. Alvira, G. Bueno, A. Lázaro, O. Bueno, J.F. León, J.Ma Garagorri, M. Bueno, I. Labayen, S. Bel Serrat, L.A. Gracia Marco, T. Mouratidou, A. Santaliestra-Pasías, P. De Miguel-Etayo, C. Julián Almárcegui, M. Miguel-Berges, I. Iguacel, J. Wärnberg, E. Nova, S. Gómez, L.E. Díaz, J. Romeo, A. Veses, B. Zapatera, T. Pozo, D. Martínez, L. Beghin, C. Iliescu, J. Von Berlepsch, W. Sichert-Hellert, E. Koeppen, E. Erhardt, K. Csernus, K. Török, S. Bokor, null Angster, E. Nagy, O. Kovács, J. Répasi, C. Codrington, M. Plada, A. Papadaki, K. Sarri, A. Viskadourou, C. Hatzis, M. Kiriakakis, G. Tsibinos, C. Vardavas, M. Sbokos, E. Protoyeraki, M. Fasoulaki, P. Stehle, K. Pietrzik, C. Breidenassel, A. Spinneker, J. Al-Tahan, M. Segoviano, A. Berchtold, C. Bierschbach, E. Blatzheim, A. Schuch, P. Pickert, M.J. Castillo, Á. Gutiérrez, J.R. Ruiz, E.G. Artero, V. España, D. Jiménez-Pavón, P. Chillón, C. Sánchez-Muñoz, M. Cuenca, D. Arcella, E. Azzini, E. Barrison, N. Bevilacqua, P. Buonocore, G. Catasta, D. Ciarapica, P. D'Acapito, M. Ferrari, M. Galfo, C. Le Donne, C. Leclercq, G. Maiani, B. Mauro, L. Mistura, A. Pasquali, R. Piccinelli, A. Polito, R. Roccaldo, R. Spada, S. Sette, M. Zaccaria, P. Vitaglione, C. Montagnese, I. De Bourdeaudhuij, T. De Vriendt, C. Matthys, C. Vereecken, M. de Maeyer, C. Ottevaere, I. Huybrechts, K. Phillipp, S. Dietrich, E. Grammatikaki, Z. Bouloubasi, T.L. Cook, S. Eleutheriou, O. Consta, G. Moschonis, I. Katsaroli, G. Kraniou, S. Papoutsou, D. Keke, I. Petraki, E. Bellou, S. Tanagra, K. Kallianoti, D. Argyropoulou, S. Tsikrika, C. Karaiskos, A. Meirhaeghe, M. Hagströmer, A.H. Wennlöf, L. Hallström, E. Patterson, L. Kwak, N. Rizzo, J. Sánchez-Molero, E. Picó, M. Navarro, B. Viadel, J.E. Carreres, G. Merino, R. Sanjuán, M. Lorente, M.J. Sánchez, S. Thomas, E. Allchurch, P. Burgess, A. Astrom, A. Sverkén, A. Broberg, A. Masson, C. Lehoux, P. Brabant, P. Pate, L. Fontaine, A. Sebok, T. Kuti, A. Hegyi, C. Maldonado, A. Llorente, E. García, H. von Fircks, M.L. Hallberg, M. Messerer, M. Larsson, H. Fredriksson, V. Adamsson, I. Börjesson, L. Fernández, L. Smillie, J. Wills, R. Pedrero-Chamizo, A. Meléndez, J. Valtueña, U. Albers, P.J. Benito, J.J. Gómez Lorente, A. Urzanqui, R.M. Torres, P. Navarro, González-Gil, E. M., Cadenas-Sanchez, C., Santabárbara, J., Bueno-Lozano, G., Iglesia, I., González-Gross, M., Molnar, D., Gottrand, F., De Henauw, S., Kafatos, A., Widhalm, K., Manios, Y., Siani, A., Amaro-Gahete, F., Rupérez, A. I., Cañada, D., Censi, L., Kersting, M., Dallongeville, J., Marcos, A., Ortega, F. B., Moreno, L. A., Gilbert, C., Libersa, C., Castelló, S., Sjöstrom, M., Molnár, D., Hall, G., Maes, L., Scalfi, L., Meléndez, P., Fleta, J., Casajús, J. A., Rodríguez, G., Tomás, C., Mesana, M. I., Vicente-Rodríguez, G., Villarroya, A., Gil, C. M., Ara, I., Alvira, J. F., Bueno, G., Lázaro, A., Bueno, O., León, J. F., Garagorri, J. Ma, Bueno, M., Labayen, I., Bel Serrat, S., Gracia Marco, L. A., Mouratidou, T., Santaliestra-Pasías, A., De Miguel-Etayo, P., Julián Almárcegui, C., Miguel-Berges, M., Iguacel, I., Wärnberg, J., Nova, E., Gómez, S., Díaz, L. E., Romeo, J., Veses, A., Zapatera, B., Pozo, T., Martínez, D., Beghin, L., Iliescu, C., Von Berlepsch, J., Sichert-Hellert, W., Koeppen, E., Erhardt, E., Csernus, K., Török, K., Bokor, S., Angster, Null, Nagy, E., Kovács, O., Répasi, J., Codrington, C., Plada, M., Papadaki, A., Sarri, K., Viskadourou, A., Hatzis, C., Kiriakakis, M., Tsibinos, G., Vardavas, C., Sbokos, M., Protoyeraki, E., Fasoulaki, M., Stehle, P., Pietrzik, K., Breidenassel, C., Spinneker, A., Al-Tahan, J., Segoviano, M., Berchtold, A., Bierschbach, C., Blatzheim, E., Schuch, A., Pickert, P., Castillo, M. J., Gutiérrez, Ã ., Ruiz, J. R., Artero, E. G., España, V., Jiménez-Pavón, D., Chillón, P., Sánchez-Muñoz, C., Cuenca, M., Arcella, D., Azzini, E., Barrison, E., Bevilacqua, N., Buonocore, P., Catasta, G., Ciarapica, D., D'Acapito, P., Ferrari, M., Galfo, M., Le Donne, C., Leclercq, C., Maiani, G., Mauro, B., Mistura, L., Pasquali, A., Piccinelli, R., Polito, A., Roccaldo, R., Spada, R., Sette, S., Zaccaria, M., Vitaglione, P., Montagnese, C., De Bourdeaudhuij, I., De Vriendt, T., Matthys, C., Vereecken, C., de Maeyer, M., Ottevaere, C., Huybrechts, I., Phillipp, K., Dietrich, S., Grammatikaki, E., Bouloubasi, Z., Cook, T. L., Eleutheriou, S., Consta, O., Moschonis, G., Katsaroli, I., Kraniou, G., Papoutsou, S., Keke, D., Petraki, I., Bellou, E., Tanagra, S., Kallianoti, K., Argyropoulou, D., Tsikrika, S., Karaiskos, C., Meirhaeghe, A., Hagströmer, M., Wennlöf, A. H., Hallström, L., Patterson, E., Kwak, L., Rizzo, N., Sánchez-Molero, J., Picó, E., Navarro, M., Viadel, B., Carreres, J. E., Merino, G., Sanjuán, R., Lorente, M., Sánchez, M. J., Thomas, S., Allchurch, E., Burgess, P., Astrom, A., Sverkén, A., Broberg, A., Masson, A., Lehoux, C., Brabant, P., Pate, P., Fontaine, L., Sebok, A., Kuti, T., Hegyi, A., Maldonado, C., Llorente, A., García, E., von Fircks, H., Hallberg, M. L., Messerer, M., Larsson, M., Fredriksson, H., Adamsson, V., Börjesson, I., Fernández, L., Smillie, L., Wills, J., Pedrero-Chamizo, R., Meléndez, A., Valtueña, J., Albers, U., Benito, P. J., Gómez Lorente, J. J., Urzanqui, A., Torres, R. M., Navarro, P., Ministerio de Economía y Competitividad (España), Consejo Superior de Investigaciones Científicas (España), European Commission, Stockholm County Council, and Ministerio de Ciencia e Innovación (España)

Subjects
Male, Pediatric Obesity, Cross-sectional study, Endocrinology, Diabetes and Metabolism, Health Status, Physiology, Medicine (miscellaneous), 030204 cardiovascular system & hematology, Body Mass Index, 0302 clinical medicine, Risk Factors, Nutrition and Dietetic, adolescents, Metabolic Syndrome, Nutrition and Dietetics, biology, Age Factors, Interleukin, Complement C4, Inflammatory biomarkers, Complement C3, Prognosis, Europe, C-Reactive Protein, Female, medicine.symptom, Inflammation Mediators, Cardiology and Cardiovascular Medicine, medicine.medical_specialty, Adolescent, Metabolic health, 030209 endocrinology & metabolism, Inflammation, 03 medical and health sciences, Sex Factors, Internal medicine, medicine, Humans, business.industry, C-reactive protein, Case-control study, medicine.disease, Endocrinology, Blood pressure, Cross-Sectional Studies, Case-Control Studies, biology.protein, Metabolic syndrome, business, Body mass index, Inflammatory biomarker, Biomarkers
Abstract

On behalf of the HELENA study group., [Background and aims] Inflammation may influence the cardio-metabolic profile which relates with the risk of chronic diseases. This study aimed to assess the inflammatory status by metabolic health (MH)/body mass index (BMI) category and to assess how inflammatory markers can predict the cardio-metabolic profile in European adolescents, considering BMI. [Methods and results] A total of 659 adolescents (295 boys) from a cross-sectional European study were included. Adolescents were classified by metabolic health based on age- and sex-specific cut-off points for glucose, blood pressure, triglycerides, high density cholesterol and BMI. C-reactive protein (CRP), tumor necrosis factor alpha (TNF-α), interleukin (IL-6), complement factors (C3, C4) and cell adhesion molecules were assessed. [Results] Metabolically abnormal (MA) adolescents had higher values of C3 (p < 0.001) and C4 (p = 0.032) compared to those metabolically healthy (MHy). C3 concentrations significantly increased with the deterioration of the metabolic health and BMI (p < 0.001). Adolescents with higher values of CRP had higher probability of being in the overweight/obese-MH group than those allocated in other categories. Finally, high C3 and C4 concentrations increased the probability of having an unfavorable metabolic/BMI status. [Conclusions] Metabolic/BMI status and inflammatory biomarkers are associated, being the CRP, C3 and C4 the most related inflammatory markers with this condition. C3 and C4 were associated with the cardio-metabolic health consistently., The HELENA Study was supported by the European Community Sixth RTD Framework Programme (Contract FOOD-CT-2005-007034) and the Stockholm County Council. This analysis was also supported by the Spanish Ministry of Science and Innovation (JCI-2010-07055) and the gs4:European Regional Development Fund (FEDER). CCS is supported by the Spanish Ministry of Economy and Competitiveness (BES-2014-068829). FBO is supported by a grant from the Spanish Ministry of Science and Innovation (RYC-2011-09011). AIR was funded by a Juan de la Cierva-Formación stipend from the Ministry of Economy and Competitiveness of the Spanish Government (FJCI-2014-19795).

Published
2017

298. Physical Activity Is Associated with Attention Capacity in Adolescents

Author

Jérémy Vanhelst, Laurent Béghin, Alain Duhamel, Yannis Manios, Denes Molnar, Sefaan De Henauw, Luis A. Moreno, Francisco B. Ortega, Michael Sjöström, Kurt Widhalm, Frédéric Gottrand, Fréderic Gottrand, Stefaan De Henauw, Marcela González-Gross, Chantal Gilbert, Anthony Kafatos, Christian Libersa, Jackie Sánchez, Mathilde Kersting, Michael Sjöstrom, Dénes Molnár, Jean Dallongeville, Gunnar Hall, Lea Maes, Luca Scalfi, Pilar Meléndez, Jesús Fleta, José A. Casajús, Gerardo Rodríguez, Concepción Tomás, María I. Mesana, Germán Vicente-Rodríguez, Adoración Villarroya, Carlos M. Gil, Ignacio Ara, Juan Revenga, Carmen Lachen, Juan Fernández Alvira, Gloria Bueno, Aurora Lázaro, Olga Bueno, Juan F. León, Jesús Mª Garagorri, Manuel Bueno, Juan Pablo Rey López, Iris Iglesia, Paula Velasco, Silvia Bel, Ascensión Marcos, Julia Wärnberg, Esther Nova, Sonia Gómez, Esperanza Ligia Díaz, Javier Romeo, Ana Veses, Mari Angeles Puertollano, Belén Zapatera, Tamara Pozo, David Martínez, Laurent Beghin, Catalina Iliescu, Juliana Von Berlepsch, Wolfgang Sichert-Hellert, Ellen Koeppen, Dénes Molnar, Eva Erhardt, Katalin Csernus, Katalin Török, Szilvia Bokor, Miklós Angster, Enikö Nagy, Orsolya Kovács, Judit Repásy, Caroline Codrington, María Plada, Angeliki Papadaki, Katerina Sarri, Anna Viskadourou, Christos Hatzis, Michael Kiriakakis, George Tsibinos, Constantine Vardavas, Manolis Sbokos, Eva Protoyeraki, Maria Fasoulaki, Peter Stehle, Klaus Pietrzik, Christina Breidenassel, Andre Spinneker, Jasmin Al-Tahan, Miriam Segoviano, Anke Berchtold, Christine Bierschbach, Erika Blatzheim, Adelheid Schuch, Petra Pickert, Manuel J. Castillo, Ángel Gutiérrez, Jonatan R. Ruiz, Enrique G. Artero, Vanesa España-Romero, David Jiménez-Pavón, Palma Chillón, Magdalena Cuenca-García, Davide Arcella, Elena Azzini, Emma Barrison, Noemi Bevilacqua, Pasquale Buonocore, Giovina Catasta, Laura Censi, Donatella Ciarapica, Paola D'Acapito, Marika Ferrari, Myriam Galfo, Cinzia Le Donne, Catherine Leclercq, Giuseppe Maiani, Beatrice Mauro, Lorenza Mistura, Antonella Pasquali, Raffaela Piccinelli, Angela Polito, Raffaella Spada, Stefania Sette, Maria Zaccaria, Paola Vitaglione, Concetta Montagnese, Ilse De Bourdeaudhuij, Tineke De Vriendt, Christophe Matthys, Carine Vereecken, Mieke de Maeyer, Charlene Ottevaere, Inge Huybrechts, Katharina Phillipp, Sabine Dietrich, Birgit Kubelka, Marion Boriss-Riedl, Eva Grammatikaki, Zoi Bouloubasi, Tina Louisa Cook, Sofia Eleutheriou, Orsalia Consta, George Moschonis, Ioanna Katsaroli, George Kraniou, Stalo Papoutsou, Despoina Keke, Ioanna Petraki, Elena Bellou, Sofia Tanagra, Kostalenia Kallianoti, Dionysia Argyropoulou, Katerina Kondaki, Stamatoula Tsikrika, Christos Karaiskos, Aline Meirhaeghe, Patrick Bergman, María Hagströmer, Lena Hallström, Mårten Hallberg, Eric Poortvliet, Nico Rizzo, Linda Beckman, Anita Hurtig Wennlöf, Emma Patterson, Lydia Kwak, Lars Cernerud, Per Tillgren, Stefaan Sörensen, Jackie Sánchez-Molero, Elena Picó, Maite Navarro, Blanca Viadel, José Enrique Carreres, Gema Merino, Rosa Sanjuán, María Lorente, María José Sánchez, Sara Castelló, Sarah Thomas, Elaine Allchurch, Peter Burguess, Annika Astrom, Anna Sverkén, Agneta Broberg, Annick Masson, Claire Lehoux, Pascal Brabant, Philippe Pate, Laurence Fontaine, Andras Sebok, Tunde Kuti, Adrienn Hegyi, Cristina Maldonado, Ana Llorente, Emilio García, Holger von Fircks, Marianne Lilja Hallberg, Maria Messerer, Mats Larsson, Helena Fredriksson, Viola Adamsson, Ingmar Börjesson, Laura Fernández, Laura Smillie, Josephine Wills, Agustín Meléndez, Pedro J. Benito, Javier Calderón, Jara Valtueña, Paloma Navarro, Alejandro Urzanqui, Ulrike Albers, Raquel Pedrero, Juan José Gómez Lorente, Lille Inflammation Research International Center - U 995 (LIRIC), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Evaluation des technologies de santé et des pratiques médicales - ULR 2694 (METRICS), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Inserm, Université de Lille, CHU Lille, Lille Inflammation Research International Center - U 995 [LIRIC], Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS], Vanhelst, Jérémy, Béghin, Laurent, Duhamel, Alain, Manios, Yanni, Molnar, Dene, De Henauw, Sefaan, Moreno, Luis A, Ortega, Francisco B, Sjöström, Michael, Widhalm, Kurt, Gottrand, Frédéric, Moreno, La, Gottrand, F, De Henauw, S, González Gross, M, Gilbert, C, Kafatos, A, Libersa, C, Sánchez, J, Kersting, M, Sjöstrom, M, Molnár, D, Dallongeville, J, Hall, G, Maes, L, Scalfi, L, Meléndez, P, Fleta, J, Casajús, Ja, Rodríguez, G, Tomás, C, Mesana, Mi, Vicente Rodríguez, G, Villarroya, A, Gil, Cm, Ara, I, Revenga, J, Lachen, C, Alvira, Jf, Bueno, G, Lázaro, A, Bueno, O, León, Jf, Garagorri, Jm, Bueno, M, Rey López, Jp, Iglesia, I, Velasco, P, Bel, S, Marcos, A, Wärnberg, J, Nova, E, Gómez, S, Díaz, El, Romeo, J, Veses, A, Puertollano, Ma, Zapatera, B, Pozo, T, Martínez, D, Beghin, L, Iliescu, C, Von Berlepsch, J, Sichert Hellert, W, Koeppen, E, Molnar, D, Erhardt, E, Csernus, K, Török, K, Bokor, S, Angster, M, Nagy, E, Kovács, O, Repásy, J, Codrington, C, Plada, M, Papadaki, A, Sarri, K, Viskadourou, A, Hatzis, C, Kiriakakis, M, Tsibinos, G, Vardavas, C, Sbokos, M, Protoyeraki, E, Fasoulaki, M, Stehle, P, Pietrzik, K, Breidenassel, C, Spinneker, A, Al Tahan, J, Segoviano, M, Berchtold, A, Bierschbach, C, Blatzheim, E, Schuch, A, Pickert, P, Castillo, Mj, Gutiérrez, Á, Ortega, Fb, Ruiz, Jr, Artero, Eg, España Romero, V, Jiménez Pavón, D, Chillón, P, Cuenca García, M, Arcella, D, Azzini, E, Barrison, E, Bevilacqua, N, Buonocore, P, Catasta, G, Censi, L, Ciarapica, D, D'Acapito, P, Ferrari, M, Galfo, M, Le Donne, C, Leclercq, C, Maiani, G, Mauro, B, Mistura, L, Pasquali, A, Piccinelli, R, Polito, A, Spada, R, Sette, S, Zaccaria, M, Vitaglione, Paola, Montagnese, C, De Bourdeaudhuij, I, De Vriendt, T, Matthys, C, Vereecken, C, de Maeyer, M, Ottevaere, C, Huybrechts, I, Widhalm, K, Phillipp, K, Dietrich, S, Kubelka, B, Boriss Riedl, M, Manios, Y, Grammatikaki, E, Bouloubasi, Z, Cook, Tl, Eleutheriou, S, Consta, O, Moschonis, G, Katsaroli, I, Kraniou, G, Papoutsou, S, Keke, D, Petraki, I, Bellou, E, Tanagra, S, Kallianoti, K, Argyropoulou, D, Kondaki, K, Tsikrika, S, Karaiskos, C, Meirhaeghe, A, Bergman, P, Hagströmer, M, Hallström, L, Hallberg, M, Poortvliet, E, Rizzo, N, Beckman, L, Wennlöf, Ah, Patterson, E, Kwak, L, Cernerud, L, Tillgren, P, Sörensen, S, Sánchez Molero, J, Picó, E, Navarro, M, Viadel, B, Carreres, Je, Merino, G, Sanjuán, R, Lorente, M, Sánchez, Mj, Castelló, S, Thomas, S, Allchurch, E, Burguess, P, Astrom, A, Sverkén, A, Broberg, A, Masson, A, Lehoux, C, Brabant, P, Pate, P, Fontaine, L, Sebok, A, Kuti, T, Hegyi, A, Maldonado, C, Llorente, A, García, E, von Fircks, H, Hallberg, Ml, Messerer, M, Larsson, M, Fredriksson, H, Adamsson, V, Börjesson, I, Fernández, L, Smillie, L, Wills, J, Meléndez, A, Benito, Pj, Calderón, J, Valtueña, J, Navarro, P, Urzanqui, A, Albers, U, Pedrero, R, and Gómez Lorente, J. J.

Subjects
Male, medicine.medical_specialty, Adolescent, Cross-sectional study, Overweight, Motor Activity, 03 medical and health sciences, 0302 clinical medicine, medicine, D2 Test of Attention, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Aerobic exercise, Humans, Attention, 030212 general & internal medicine, Effects of sleep deprivation on cognitive performance, Child, Exercise, 2. Zero hunger, [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics, business.industry, International Standard Classification of Education, [SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences, Cognition, Mesh:Adolescent, Mesh:Attention, Mesh:Child, Mesh:Cross-Sectional Studies, Mesh:Exercise, Mesh:Female, Mesh:Humans, Mesh:Male, Mesh:Motor Activity, 030229 sport sciences, Cross-Sectional Studies, Pediatrics, Perinatology and Child Health, Physical therapy, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Female, medicine.symptom, business, Body mass index, Clinical psychology
Abstract

International audience; Objective: To assess the relationships among physical activity, measured objectively, and attention capacity in European adolescents.Study design: The study included 273 adolescents, aged 12.5-17.5 years, who participated in the Healthy Lifestyle in Europe by Nutrition in Adolescence Study. Participants wore a uniaxial accelerometer for 7 days to measure physical activity. The d2 Test of Attention was administered to assess attention capacity. Multivariate analyses were used to study the association of attention capacity with each measure of physical activity. Receiver operating characteristic analysis was performed to determine thresholds that best discriminate between low and good attention capacity.Results: After controlling for potential confounding variables (age, sex, body mass index, parental educational level, fat mass, aerobic fitness, and center), adolescents' attention capacity test performances were significantly and positively associated with longer time spent in moderate or moderate-to-vigorous physical activity (MVPA) in free-living conditions (P < .05). Receiver operating characteristic curve analyses revealed that the physical activity thresholds that best discriminated between low/good attention capacities were ≥41 min·day−1 for moderate, ≥12 min·day−1 for vigorous, and ≥58 min·day−1 for MVPA.Conclusion:These findings suggest that promoting MVPA may be have a beneficial effect on attention capacity, an important component of cognition, in adolescents.

Published
2015

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