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1. The effect of daily supplements of 20-30 mg inorganic iron as ferrous sulphate on the growth, activity and haematological status of preschool children was studied for 3.5, 7 and 12 months and compared to that of children who served as controls. All children were given their daily requirements of energy and protein. In addition, they received 5 microgram cyanocobalamin and 200 microgram folic acid. 2. Fe supplementation increased the haemoglobin, serum Fe and percentage saturation of transferrin and reduced the unsaturated Fe-binding capacity significantly compared to corresponding values for the controls. 3. Height and activity were unaffected by Fe supplements. 4. Of the children 45% had haemoglobin values below 110 g/l at the end of 7-12 months of Fe supplementation.

The serum of 134 patients infected with Schistosoma mansoni, including both acute and chronic forms of the disease, were tested for the presence of cold lymphocytotoxins. These were found in 4.5% of acute forms of the disease, in 88.4% of chronic infections and in only 9.8% of the uninfected control group (blood donors). An analysis of the results suggests a probable role for cold lymphocytotoxins in the immune response of the different phases of human schistosomiasis.

The immunization status and frequency of contraindications to immunization were studied in 446 children attending the paediatric clinic of a teaching hospital in south India. In all, 27% of the children were up to date in their immunizations, 19% had a contraindication, and 57% required and could safely be given immunizations. A policy of offering immunizations in paediatric clinics to all who require them and who do not have a contraindication would result in protection of a significant number of unimmunized children.

The effect of illness on the food intake of 125 preschool children in a residential home was studied. The children had a mean of 6.8 episodes of illness per child per year. Upper respiratory infections, diarrhoeas and fevers depressed food intake by 15-20%. Measles resulted in prolonged and profound depression of appetite, and caused weight losses in the affected children. The number of days of depressed appetite due to illness had a cumulative effect on growth; poor increases in height and weight were seen in these children who had many days of reduced appetite due to illness. Measles vaccination is strongly recommended for improved growth and nutritional status of preschool children.

The faecal flora of 29 healthy infants and young children was compared with that of 49 children of similar age and socio-ecomonic status with acute gastroenteritis. In the healthy children the most common organisms in the faeces were bifidobacteria, veillonellae, enterobacteria and enterodocci with anaerobes outnumbering aerobes. Most members of the noraml faecal flora were present in the diarrhoeal stools, but anaerobes were signigicantly reduced in number and enterobacteria were significantly increased, thereby altering the ratio of anaerobes to aerobes. The alterations in the flora were not related to the nature of the aetiological agent or to the severity of the diarrhoea. The changes appeared to be a direct result of the altered colonic environment produced by the diarrhoeal state. In 13 of the 28 patients from whom bacterial pathogens were isolated, the pathogens were the predominant faecal organsims.

We evaluated prospectively the utility of a latex agglutination technique for the diagnosis of Haemophilus influenzae type b meningitis in a paediatric ward in India. Eight of 44 children had H. influenzae grown from cerebrospinal fluid. These proven cases plus four additional cases of H. influenzae meningitis were detected by the latex agglutination test. There were no cross reactions with other organisms. The high degree of sensitivity and specificity, combined with the speed and simplicity of this technique make it an appropriate method for developing countries.

The diets of women, studied at regular intervals in the first year of lactation, showed that food taboos adversely affected the daily intake of energy, protein and some nutrients in the first month. Despite the poor intakes, the women breastfed their babies successfully and the weight gained by the babies in the early months was satisfactory. Breast feeding continued until the next pregnancy. Most women believed lactation prevented conception.

The microbial flora of the jejunal lumen of 28 infants with acute gastroenteritis was compared with that of a group of 10 normal infants. The jejunum of control subjects harboured an "oral" type of flora and in a few instances enterobacteria in small numbers. The concentrations of all but one of the groups of organism were higher in the patients than in controls, and the differences were of statistical significance for enterobacteria and lactobacilli. In eight subjects, the same pathogen was identified in the jejunum and the stool. In six subjects with rotavirus infection, there were almost no Gram-negative aerobic rods in the jejunum. The possible role of other Gram-negative aerobic rods in producing gastroenteritis is discussed. It is suggested that studies of jejunal flora are of considerable importance in assigning an aetiological role to bacteria in the causation of acute gastroenteritis.

Thirtytwo varieties of edible green leaves were analysed for their beta carotene content in different seasons of the year. Several varieties were found to contain enough beta carotene to provide the daily requirements of vitamin A, even for an adult person, from a moderate serving (30g-100g).