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Objective: The aim of this review is to summarize the production process, types, characteristics, and application of different food-grade aerogels in sensing of food adulterants, and delivery vehicle of bioactive compounds. Materials and Methods: As an emerging material, food-grade aerogels are being used to develop functional food materials (delivery vehicle for bioactive compounds, nutraceuticals, etc. and sensing material for the detection of pesticides, spoilage, etc.). Impregnation of functional compounds in food-grade aerogels have potential in Food Industries. Results and Discussion: Food-grade aerogels exhibit tremendous potential in food packaging-based applications as a moisture absorber, bioactive compound releaser, carrying material, preserver, etc. It also has the potential to serve as target-based delivery vehicle, improves bioavailability of loaded materials, protects them from adverse environment and essential oil incorporated oleogel, etc. Moreover, food-grade aerogels are biodegradable in nature. It is noteworthy mentioning that how the precursor material and production process influences the characteristics of food-grade aerogels also summarized. Conclusion: Food-grade aerogels (polysaccharide, protein, and mucilage based) are fulfilling the need for food application due to their exceptional properties (high porosity, high specific surface area, and very low density). [ABSTRACT FROM AUTHOR]

Introduction. Stem cell-based therapies are emerging enormously as a ray of hope and a therapeutic alternative for ovarian rejuvenation, regeneration and follicular development in women with impaired ovaries mainly due to primary ovarian insufficiency or premature ovarian failure. In all cases of ovarian impairment, such as poor ovarian response and diminished ovarian reserve or primary ovarian insufficiency, there remains a need for methods to restore fertility in patients seeking reproductive success, but where oocyte donation had been the only practical option. As per the studies reported, within the ovarian context, the infusion of the whole population of human bone marrow-derived stem cells promote human follicle growth, ovarian local vascularization, increase follicle and stromal cell proliferation, and reduce apoptosis and atresia, providing an adequate ovarian niche for follicular rescue in patients with impaired or aged ovarian reserve. Methodology. Based on this, we aimed to evaluate the effects of autologous bone marrow-derived stem cell ovarian transplant on the ovarian reserve of poor responder women with very poor prognosis. With this purpose, we designed a method to mobilize, collect and deliver bone marrow-derived stem cells directly to human ovaries. Bone marrow aspiration done from ileac crest and BMAC concentrate prepared and infused to patient by laparoscopy in ovaries and other group PRP have been injected into ovaries stroma by transvaginal injections. Results. This unique study developed in patients showed that autologous bone marrow-derived stem cell ovarian transplant improves the ovarian reserve biomarkers and reproductive outcomes, resulting in more follicles and oocytes developed after ovarian stimulation. Conclusions. This technique allowed spontaneous pregnancies in poor responder women previously limited to egg donation, but further research is still needed as the embryo euploidy was not modified by the stem cells therapy. The diagnostic hormonal levels improved post-procedure; there was a reduction in FSH and an increase in AMH and in estradiol levels. [ABSTRACT FROM AUTHOR]

Chronic hepatitis B, a major cause of liver disease and cancer, affects >250 million people worldwide. Currently there is no cure, only suppressive therapies. Efforts to develop finite curative hepatitis B virus (HBV) therapies are underway, consisting of combinations of multiple novel agents with or without nucleos(t)ide reverse-transcriptase inhibitors. The HBV Forum convened a webinar in July 2021, along with subsequent working group discussions to address how and when to stop finite therapy for demonstration of sustained off-treatment efficacy and safety responses. Participants included leading experts in academia, clinical practice, pharmaceutical companies, patient representatives, and regulatory agencies. This Viewpoints article outlines areas of consensus within our multistakeholder group for stopping finite therapies in chronic hepatitis B investigational studies, including trial design, patient selection, outcomes, biomarkers, predefined stopping criteria, predefined retreatment criteria, duration of investigational therapies, and follow-up after stopping therapy. Future research of unmet needs are discussed. [ABSTRACT FROM AUTHOR]

In mammals, a complex array of oral sensors assess the taste, temperature and haptic properties of food. Although the representation of taste has been extensively studied in the gustatory cortex, it is unclear how the somatosensory cortex encodes information about the properties of oral stimuli. Moreover, it is poorly understood how different oral sensory modalities are integrated and how sensory responses are translated into oral motor actions. To investigate whether oral somatosensory cortex processes food-related sensations and movements, we performed in vivo whole-cell recordings and motor mapping experiments in rats. Neurons in oral somatosensory cortex showed robust post-synaptic and sparse action potential responses to air puffs. Membrane potential showed that cold water evoked larger responses than room temperature or hot water. Most neurons showed no clear tuning of responses to bitter, sweet and neutral gustatory stimuli. Finally, motor mapping experiments with histological verification revealed an initiation of movements related to food consumption behavior, such as jaw opening and tongue protrusions. We conclude that somatosensory cortex: (i) provides a representation of the temperature of oral stimuli, (ii) does not systematically encode taste information and (iii) influences orofacial movements related to food consummatory behavior. [ABSTRACT FROM AUTHOR]

This study aims to identify clinically meaningful sex differences in efficacy and selected safety adverse events for the treatment of chronic hepatitis C virus infection (HCV) or HIV/HCV co‐infection in those receiving combination direct‐acting antiviral (DAA) regimens. Our assessment was based on adult trial participants treated at the approved DAA dosage and treatment duration from 40 phase 3 clinical trials submitted to the FDA. Female enrollment ranged from 11% to 54% (overall mean 38%). Females with HCV genotype (GT) 1 or 3 infection had statistically significant higher unadjusted or covariant‐adjusted odds of achieving sustained virologic response at post‐treatment Week 12 (SVR12) compared with males. Odds ratios favouring females were observed among Whites and those ≥40 years of age with HCV GT1 or 3 infections, and among those ≥50 years of age, non‐cirrhotic and those with HCV GT3 infection who were treatment‐experienced. These differences were not clinically relevant due to the high SVR12 rate achieved by females and males, overall or in subgroups. No differences were observed in SVR12 rates between HCV GT1 mono‐infected and HCV GT1/ HIV‐1 co‐infected participants. Numerically, more females reported headache, fatigue and nausea compared to males, but the differences were small and predominately Grade 1 or 2 severity. Discontinuation rates for any reason or due to an adverse event were low and similar between the sexes. Our study demonstrated females successfully complete DAA regimens and achieve high SVR12 rates despite numerically higher adverse events for certain commonly reported events. [ABSTRACT FROM AUTHOR]

Introduction: On 4 February, 2020, the Secretary of the Department of Health and Human Services declared a public health emergency related to coronavirus disease 2019 (COVID-19), and on 27 March, 2020 declared circumstances existed to justify the authorization of the emergency use of drug and biological products (hereafter, "drugs") for COVID-19. At the outset of the pandemic with uncertainty relating to the virus, many drugs were being used to treat or prevent COVID-19, resulting in the US Food and Drug Administration's (FDA's) need to initiate heightened surveillance across these drugs. Objective: We aimed to describe the FDA's approach to monitoring the safety of drugs to treat or prevent COVID-19 across multiple data sources and the subsequent actions taken by the FDA to protect public health. Methods: The FDA conducted surveillance of adverse event and medication error data using the FDA Adverse Event Reporting System, biomedical literature, FDA-American College of Medical Toxicology COVID-19 Toxicology Investigators Consortium Pharmacovigilance Project Sub-registry, and the American Association of Poison Control Centers National Poison Data System. Results: From 4 February, 2020, through 31 January, 2022, we identified 22,944 unique adverse event cases worldwide and 1052 unique medication error cases domestically with drugs to treat or prevent COVID-19. These were from the FDA Adverse Event Reporting System (22,219), biomedical literature (1107), FDA-American College of Medical Toxicology COVID-19 Toxicology Investigator's Consortium Sub-registry (638), and the National Poison Data System (32), resulting in the detection of several important safety issues. Conclusions: Safety surveillance using near real-time data was critical during the COVID-19 pandemic because the FDA monitored an unprecedented number of drugs to treat or prevent COVID-19. Additionally, the pandemic prompted the FDA to accelerate innovation, forging new collaborations and leveraging data sources to conduct safety surveillance to respond to the pandemic. [ABSTRACT FROM AUTHOR]

[Display omitted] • Resin and enzymatic hydrolysis combined with sonication is applied for the first time. • Sonication-assisted resin debittering results in a lowered level of bitterness. • Sonication markedly influenced the phytochemical properties of pomelo juice. • Sonication assisted enzymatic hydrolysis improved the flavor, chemical and phytochemical properties. • Significant improvement in enzymatic activities and degradation of naringin. In the present study, sonication assisted debittering of pomelo fruit juice was carried out and the effect of sonication along with resin/enzyme on the chemical, phytochemical and volatile composition of juice was also investigated. The optimum conditions for sonication coupled debittering using resin were 50 kHz, 2 min, and 45 ℃ while 50 kHz, 60 min, and 60 ℃ were obtained for enzyme hydrolysis. Sonication treatment not only reduced the debittering time but also enhanced the adsorption and hydrolysis of naringin by 17% and 20% in resin and enzyme respectively. In addition, enzymatic activity was also improved and weakened C-O bonds in naringin. At the same time, sonication significantly affected the bioactive compounds of juice, chemical composition, and volatile compounds of juice. Flavor compounds including octanal, linalool, citral, and ethyl butyrate were enhanced by sonication-assisted enzymatic treated juice. [ABSTRACT FROM AUTHOR]

Smartphone-based sensors (SPBS) along with communication and data as a part of the Internet of Things (IoT) have the potential to bring about a significant transformation in food safety by enabling customers to conduct screening tests. Additionally, fish spoilage is a critical issue in the fish industry, leading to economic losses and public health concerns. Traditional methods for assessing fish freshness are often labor-intensive and time-consuming. To address these challenges, it is crucial to comprehensively review ongoing research efforts and pinpoint key technological gaps. Consequently, we conducted a systematic review focusing on SPBS for fish spoilage analysis. We present an overview of the SPBS that were reviewed, emphasizing their performance characteristics. Additionally, we provided insights into the current state of the art concerning commercially available SPBS. This analysis has identified several notable technology gaps, with the most prominent ones being (i) the use of smartphone-based sensors in fish analysis, (ii) its applications using different modes of analysis, (iii) the advantages over analytical method, (iv) its limitation, and (v) recent development, challenges, and future trends. Advancements in optical sensor fabrication, miniaturization, and cost reduction, along with sophisticated machine learning algorithms and cloud computing capabilities, are driving significant developments in mobile diagnostics. Limited review and research were encountered for smartphone-based sensors for fish analysis. This opens the possibility areas for future researchers to detect fish spoilage using smartphone-based sensors. [ABSTRACT FROM AUTHOR]

Artocarpus are members of the Moraceae family who are believed to be a large family comprises of nearly 60 genera and about 1400 species. The most important genus of the Moraceae family is Ficus, Morus and Artocarpus. The extract and bioactive compounds from bark, leaves, seeds and pericarp of monkey fruit have shown to possess exceptional phytochemical, nutritional and valuable pharmacological properties. This fruit is capable of offering numerous inhibitory factors such as antibacterial, antitubercular, antiviral, antifungal, antiplatelet, antiarthritic, tyrosinase inhibitory and cytotoxicity. This review devotes the complete overview of pharmacological and bioactive components exclusively found in the monkey fruit and its parts. However, fruit exhibits appreciable properties, but they are still unknown as well as underutilized. The remarkable properties of plants and the modern approaches are needed for the treatment of chronic diseases, the development of drugs and functional food products, or for the improvement of properties existed ones. [ABSTRACT FROM AUTHOR]

We developed a cost-effective, user-friendly smartphone-based sensor equipped with a polyaniline (PANI) label along with optical components and monitored the freshness of three different varieties of fish fillets i.e., Rohu (Labeo rohita), Mullet (Mugil cephalus), and Common Carp (Cyprinus carpio) during storage. We designed an optical cradle as an accessory for a smartphone using ZW3D software and a 3D printer. The cradle with the smartphone was used to observe the spectrum of developed polyaniline deposited labels for ascertaining fish freshness. The sensor was calibrated using a standard ammonia solution (0–400 ppm) and the method was validated with a spectrophotometer and existing conventional techniques like TVB-N (total volatile basic nitrogen), TVC (total visible count), pH, and TPA (Texture Profile Analysis). The limit of detection (LOD), the limit of quantification (LOQ), %Bias, and %RSD of the sensor were 3.83 ppm, 12.96 ppm, 0.14 %, and 1.87 % respectively. The developed smartphone-based sensor used about 1139 pixels for wavelengths between 391.84 and 633.54 nm. A strong correlation could be established between TVB-N, TVC, and pH with the findings of the developed sensor. Application of PANI made the sensor specific for the detection of spoilage of fish therefore can be utilized as a platform for monitoring the freshness of fish. We successfully developed a web application using the present findings to evaluate fish fillet quality. [Display omitted] • Parts to hold the optical elements for smartphone was developed using ZW3D, and assembled to the phone's rear camera. • Polyaniline label was successfully developed on a optically inactive polystyrene sheet. • The detection limit, %Bias, and %RSD of the sensor were 3.83 ppm, 0.14 %, and 1.87 % respectively. • The freshness of three varieties of fish was evaluated successfully using sensor. • Web application was successfully developed using the present results. [ABSTRACT FROM AUTHOR]

[Display omitted] • IDE sensor for naringin quantification in Pomelo fruit to predict maturity. • Sensor exhibits excellent selectivity for naringin and sensitivity of 0.008 µA for 10 ppb naringin. • Sensor can effectively quantify naringin in µM concentration. • Pomelo harvesting at 180–220 DAFS result maximum bioactive compounds. • Sensor determined naringin content effectively in other citrus cultivars also. Maturity determination of pomelo fruits having health-benefiting attributes is an important issue to enhance the quality of harvesting. Here, an interdigitated electrode (IDE) based sensor is introduced to detect its maturity by determining the naringin content. The sensor was made by depositing amberlite IRA-400 as a sensing layer on IDE patterned PCB substrate at room temperature with hydrothermal and spin-coating techniques. The sensor exhibits excellent selectivity for naringin, high sensitivity of 0.008 µA for 10 ppb of naringin, and reusability up to 3–4 times for naringin quantification in maturity testing of fruits. The pomelo fruits start to mature when maximum values of current response and naringin content are found at 140 DAFS. The naringin content decreases as maturity progresses and maximum phytochemical attributes were obtained at 180–220 DAFS. The IDE sensor assures an appropriate period of plucking of pomelo fruits improving harvesting practices and trade of citrus fruits. [ABSTRACT FROM AUTHOR]

The study aimed to develop a novel eutecto-oleogel and its characterizations. Using starch, beeswax, oil, and natural deep eutectic solvents (NADES), an oleogel with low hardness and high liquid fat was developed. The addition of starch and NADES in oleogels caused the formation of new intra or intermolecular hydrogen bonding and improved the oil binding capacity, thermal behavior, and texture of the oleogels. The oleogel with 1 % starch formed a strong gel with the most favorable functional, textural, flow properties and a high fanning factor. Complementary tests of the oleogel exhibited shear thinning and frequency-independent behavior, with zero residual effect. Non-isothermal crystallization and melting analysis of the oleogels showed noticeable differences among the various oleogels. These results contribute to a better understanding of oleo gelation in rice bran oil-based oleogels with NADES, and beeswax for formulating food, pharmaceutical, and personal care products with desired physical properties., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier B.V. All rights reserved.)

Cellulose-based materials are a viable alternative to petroleum-based sources; however, the practical applicability of cellulose films is severely limited by their poor hydrophobicity. This study explores the development of hydrophobic films with self-healing properties through the incorporation of natural wax into a cellulose matrix. Different formulations of films were developed varying the concentration of glycerol (0 % to 3.5 % v/v) and aminolysis treatment. Printability property, rubbing, acid, and water resistance property of the film were also evaluated. The self-healing efficiency of the films varied from around 30 % to 80 % based on variations in glycerol and aminolysis treatment provided. Aminolysis-treated films showed enhanced self-healing properties (Self-healing efficiency ~77 %) compared to the control films. The films were characterized for their physical, mechanical, barrier, and thermal properties and it was found that 1.5 % had superior properties compared to other compositions. Printability properties showed that aminolysis-treated films had better wetting properties (WCA ~ 74.46°) with a peak tact force of 8.1 N. This signifies aminolysis-treated films had better ink absorption and adhesion properties, which confirms the printability nature of the films. This study highlights the potential applications of biodegradable self-healing based film, applications with a scope of resolving environmental problems by replacing petrochemical plastics., Competing Interests: Declaration of competing interest The authors have no financial or non-financial interests to disclose., (Copyright © 2024 Elsevier B.V. All rights reserved.)

What physiological role does a slow hyperpolarization-activated ion channel with mixed cation selectivity play in the fast world of neuronal action potentials that are driven by depolarization? That puzzling question has piqued the curiosity of physiology enthusiasts about the hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, which are widely expressed across the body and especially in neurons. In this review, we emphasize the need to assess HCN channels from the perspective of how they respond to time-varying signals, while also accounting for their interactions with other co-expressing channels and receptors. First, we illustrate how the unique structural and functional characteristics of HCN channels allow them to mediate a slow negative feedback loop in the neurons that they express in. We present the several physiological implications of this negative feedback loop to neuronal response characteristics including neuronal gain, voltage sag and rebound, temporal summation, membrane potential resonance, inductive phase lead, spike triggered average, and coincidence detection. Next, we argue that the overall impact of HCN channels on neuronal physiology critically relies on their interactions with other co-expressing channels and receptors. Interactions with other channels allow HCN channels to mediate intrinsic oscillations, earning them the "pacemaker channel" moniker, and to regulate spike frequency adaptation, plateau potentials, neurotransmitter release from presynaptic terminals, and spike initiation at the axonal initial segment. We also explore the impact of spatially non-homogeneous subcellular distributions of HCN channels in different neuronal subtypes and their interactions with other channels and receptors. Finally, we discuss how plasticity in HCN channels is widely prevalent and can mediate different encoding, homeostatic, and neuroprotective functions in a neuron. In summary, we argue that HCN channels form an important class of channels that mediate a diversity of neuronal functions owing to their unique gating kinetics that made them a puzzle in the first place., (© 2023 The Authors. Proteins: Structure, Function, and Bioinformatics published by Wiley Periodicals LLC.)

Impact of glycerol on the physico-functional, morphological, mechanical, and rehydration properties of corn starch-based aerogel has been investigated. The aerogel was prepared from hydrogel (sol-gel method) using solvent exchange and supercritical CO 2 drying. Glycerol-infused aerogel had a more connected, denser structure (0.38-0.45 g/cm 3 ), enhanced hygroscopic behavior, and was reusable up to eight times in terms of its capacity to absorb water after being drawn from the soaked sample. However, the inclusion of glycerol reduced the aerogel's porosity (75.89-69.91 %) and water absorption rate (WAR; 118.53-84.64 %) but enhanced its percentage shrinkage (75.03-77.99 %) and compressive strength (26.01-295.06 N). The most effective models for describing the rehydration behavior of aerogel were determined to be the Page, Weibull, and Modified Peleg models. Glycerol addition improved the internal strength of the aerogel so could be recycled without significant change in the physical characteristics of the aerogel. By effectively eliminating the condensed moisture that was developed inside the packing owing to the transpiration of fresh spinach leaves, the aerogel extended the storage life of the leaves by up to eight days. The glycerol-based aerogel has the potential to be employed as a carrier matrix for various chemicals and a moisture scavenger., Competing Interests: Declaration of competing interest We don't have any conflict of Interest to declare with the submitted manuscript., (Copyright © 2023 Elsevier B.V. All rights reserved.)

Ethnomedicinal plants are a rich reservoir of active compounds with potent pharmacological properties. Therefore, plants could serve as a source for the discovery of active antimicrobial and antioxidant agents and are focused because of their low toxicity, economic viability, easy availability, etc. In this regard, phytochemical analyses, viz. β-carotene, total sugar, reducing sugar, vitamin C, total carotenoids, protein, total phenolic content (TPC), and total flavonoid content (TFC) of 20 ethnomedicinal plants of North East India (NEI) were evaluated in this study. The antibacterial activity against human pathogens and antioxidant potential of plant extracts was also demonstrated. The minimum inhibitory concentration (MIC 80 ), minimum bactericidal concentration (MBC), and total antibacterial activity (TAA) of the active extracts were evaluated against Pseudomonas aeruginosa and Chromobacterium violaceum. The active extracts were also examined for antibiofilm as well as anti-pyocyanin activities against P. aeruginosa and anti-QS activity against C. violaceum at sub-MICs. The study demonstrated variable concentration of phytochemicals of the extracts, viz. β-carotene (0.29-8.91 mg g -1 ), total sugar (2.92-30.6 mM), reducing sugar (0.44-14.5 mM), vitamin C (8.41-31.3 mg g -1 ), total carotenoids (14.9-267.0 mg g -1 ), protein (5.65-283 mg g -1 ), TPC (5.32-31.0 mg GAE/g DW), and TFC (1.74-68.2 mg QE/g DW). The plant extracts also exhibited potent antioxidant and antibacterial activities against both Gram-positive and Gram-negative bacteria. Some of the extracts also demonstrated significant biofilm inhibition and eradication, anti-pyocyanin, and anti-QS activities at sub-MICs. The selected ethnomedicinal plants are rich in phytochemicals and demonstrated potent antioxidant, antibacterial, and antibiofilm activities, thus could serve as the important source of novel antioxidant and antimicrobial agents., (© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)

Background & Aims: Seroclearance of hepatitis B surface antigen (HBsAg) is the desired end point of treatment for chronic hepatitis B virus (HBV) infection, according to guidelines. We performed a systematic review and meta-analysis to evaluate the strength of the association between HBsAg seroclearance and long-term clinical outcomes., Methods: We performed a systematic review of the PubMed, EMBASE, and Cochrane Library databases for articles that assessed HBsAg status and reported the incidence of hepatocellular carcinoma (HCC), liver decompensation, liver transplantation, and/or all-cause mortality during follow-up evaluation. We performed a meta-analysis of rate ratios (RR) using a random-effects model independently for each end point and for a composite end point., Results: We analyzed data from 28 studies, comprising a total of 188,316 patients with chronic HBV infection (treated and untreated), and 1,486,081 person-years (PY) of follow-up evaluation; 26 reported data on HCC, 7 on liver decompensation, and 13 on liver transplantation and/or death. The composite event rates were 0.19/1000 PY for the HBsAg seroclearance group and 2.45/1000 PY for the HBsAg-persistent group. Pooled RRs for the HBsAg seroclearance group were 0.28 for liver decompensation (95% CI, 0.13-0.59; P = .001), 0.30 for HCC (95% CI, 0.20-0.44; P < .001), 0.22 for liver transplantation and/or death (95% CI, 0.13-0.39; P < .001), and 0.31 for the composite end point (95% CI, 0.23-0.43; P < .001). No differences in RR estimates were observed among subgroups of different study or patient characteristics., Conclusions: In a systematic review and meta-analysis, we found seroclearance of HBsAg to be associated significantly with improved patient outcomes. The results are consistent among different types of studies, in all patient subpopulations examined, and support the use of HBsAg seroclearance as a primary end point of trials of patients with chronic HBV infection., (Copyright © 2021. Published by Elsevier Inc.)

Bitterness and tartness are one of the crucial reasons for the poor commerciality of Pomelo fruits. The present study intends to optimize the process variables such as resin concentration (Amberlite IRA-400) (3-10 g), time exposure (10-60 s), and stirring speed (300-1000 rpm) for removal of naringin content and tartness using response surface methodology. All the independent variables have shown a significant effect on naringin content, titrable acidity, and vitamin C content of pomelo juice. The optimized process variables for debittering and deacidification were 3.27 g resin concentration, 60 s time and 1000 rpm stirring speed, and the naringin content and titrable acidity at these optimized conditions were 0.22 mg ml -1 and 0.64% citric acid equivalent respectively. The treated juice under optimum conditions was analyzed for physicochemical properties where pH, clarity, and L* value of juice increased. In contrast, total soluble solids, vitamin C content, and a* value decreased slightly. The finding of present investigation will be helpful to improve the commercial acceptability of the sour variety of citrus fruit juice., (© Association of Food Scientists & Technologists (India) 2020.)

Hog plum juice powder was obtained from its juice under optimized condition by spray drying with juice: maltodextrin ratio at 2:1, 4:1 and 6:1 (v/w) basis. The inlet temperature and feed rate were varied between 120 to 175 °C and 8 to 14 mL/min. The effect of variables i.e. maltodextrin level, temperature and feed rate on the physicochemical properties and total phenolic content were studied. Moisture content, hygroscopicity, bulk density, water activity and total phenolic content of the powder were significantly affected by inlet temperature and maltodextrin level. However feed rate showed no any significant effect on the bulk density of the powder. An increase in inlet temperature and maltodextrin level reduced the total phenolic content in the spray dried powder. Morphological study showed that at high inlet temperature the spray dried powder were of smooth surfaces however, at low inlet temperature majority of the particles were of shrivelled surfaces. Spray dried hog plum juice powder made with 3.9:1 juice: maltodextrin, processed at 171 °C inlet temperature and at 8 mL/min feed rate had less hygroscopicity, water activity, moisture content and potent TPC content. Storage temperature significantly affected the TPC and DPPH free radical scavenging activity of the powder. Refrigeration temperature was found to be more effective to reduce the losses of TPC and DPPH free radical scavenging activity during storage. Colour acceptability of the refrigerated sample was comparatively more than to the sample stored at room temperature.