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We report a hitherto poorly documented cause of failure of curriculum implementation. The case of the clinical training of foreign medical graduates (externs) in Hong Kong is used to illustrate problems that may arise in professional education where in-service work in institutions is part of the educational process. The example is particularly relevant to health professional education which generally involves a significant in-service component. We used participant observation, questionnaires and brief interviews to obtain data from 97 externs and 48 supervisors. The results indicated that between a third and a half of the externs did not receive experiences as designated in the curriculum. Apart from age, individual characteristics of the externs did not show statistically significant relationships to the kind of experience obtained. The major significant variable (P less than 0.01) was the type of hospital where the exposure was gained. In one type of hospital the externs shared the work-load, whilst in the other type they were largely used as observers with minor technical duties. The supervisors' perception of the externs' professional capabilities varied according to the hospital. We believe that the failure of curriculum implementation was related to conflict between institutional needs, which must be safeguarded by the supervisors, and the educational needs of the learners. This conflict affects the perceptions of the supervisors and without their full cooperation the curriculum cannot be delivered. The roles and perceptions of supervisor and learner must overlap sufficiently for the system to be effective and this must be taken into account by curriculum planners.

This series of experiments examined zero-delay matching-to-sample performance in pigeons with element and compound sample stimuli. In Experiment 1, compound sample stimuli were consistently followed by compound comparison stimuli and matching accuracy during testing was equivalent to element sample-element comparison trials on the color dimension. In Experiment 2, element comparisons suddenly introduced following compound samples produced a decrement on the line dimension only. Subsequent testing at various sample durations revealed higher matching accuracy following element samples than following compound samples on both the color and line-tilt dimensions. Experiment 3 replicated the results of Experiments 1 and 2 and also demonstrated that the superiority of element over compound matching performance remains constant over the sample durations tested. In Experiment 4 testing at sample durations up to 30 sec produced an overall decrement in matching performance, but again the element vs compound matching difference remained constant. The stimulus-generalization decrement hypothesis provided a better explanation of these results than either the information-overload hypothesis or the rule hypothesis.

The advancement of any profession is based upon research which when critically evaluated may be incorporated into a knowledge base. When research is poorly conducted and published in a reputable journal, the results can have serious consequences for the practitioner, profession and clinical populations. One such case is cited and critically evaluated which should be of concern to the profession. Several areas of responsibility are discussed with the view that efforts should be made to maintain and extend research and critical evaluation skills.

For he called pope Leo IX not pontifex but pompifex and pulpifex; the Roman Church a council of vanity, the church of the malignant; and the Apostolic See the seat of Satan.’ This hostile epitaph, and more in the same vein, was written in 1088, the year that Berengar died. They are perhaps unequal crimes: to call even a scion of the German aristocracy ‘not pope but a maker of pomp’ or (worse still) ‘pulp’, and to reject the entire Roman Church as an institution. The charges are based on Lanfranc’s indictment of twenty-five years before: that Berengar had ignored the judgements of pope and council and despised the testimony of the faithful throughout the ages, saying that in himself and his followers only was the true Church to be found on earth.

SUMMARY In frame experiments on cabbage and cauliflower seedlings, sprays of dichlofluanid (at 0·05–0·2 per cent a.i.) gave excellent protection against downy mildew on the cotyledons, but unreliable protection of the true leaves. There was an improvement in control of the disease on the leaves by the addition of a non-ionic wetter to the commercial formulation of the fungicide, though there were some indications of possible phytotoxicity.

Background A new disease class of syndromes, described as linkeropathies, which are derived from defects in the glycosaminoglycan-linker region as well as glycosaminoglycan-side chains of proteoglycans is increasingly being recognized as a cause of human disease. Proteoglycans are an essential component of the extracellular matrix. Defects in the enzymatic process of proteoglycan synthesis broadly occur due to the incorrect addition of side chains. Previously, homozygous missense variants within the B3GAT3 gene encoding beta 1,3 glucuronyltransferase 3(GlcAT-I) responsible for the biosynthesis of glycosaminoglycans have been described in 7 individuals. Case presentation In this study, a 4-year-old patient with a severe phenotype of osteoporosis, hypotonia, joint laxity, fractures, scoliosis, biscuspid aortic valve and myopia was referred for next generation sequencing after extensive negative clinical testing. Whole exome sequencing was performed on the proband and his unaffected parents to identify the molecular basis of his disease. Sequencing revealed compound heterozygous variants in B3GAT3: c.1A > G (p.Met1?) and c.671 T > A (p.L224Q). Clinical and in vitro functional studies were then completed to verify the pathogenicity of the genotype and further characterize the functional basis of the patient’s disease demonstrating the patient had a decrease both in the protein level of B3GAT3 and in the glucuronyltransferase activity when compared to control samples. Independent in vitro assessment of each variant confirmed the B3GAT3: c.1A > G (p.Met1?) variant is functionally null and the c.671 T > A (p.L224Q) missense variant has significantly reduced glucuronyltransferase activity (~3% of control). Conclusions This is the first report of a patient with compound heterozygosity for a null variant in trans with a missense in B3GAT3 resulting in a severe phenotype, expanding both the genotypic and phenotypic spectrum of B3GAT3-related disease. Electronic supplementary material The online version of this article (doi:10.1186/s12881-016-0344-9) contains supplementary material, which is available to authorized users.