Search

We present simultaneous XMM-Newton and NuSTAR observations spanning 3–78 keV of the nearest radiogalaxy, Centaurus A (Cen A), performed during a very high flux state. The accretion geometry around thecentral engine in Cen A is still debated, and we investigate possible configurations using detailed X-ray spectralmodeling. NuSTAR imaged the central region of Cen A with subarcminute resolution at X-ray energies above10 keV for the first time, but finds no evidence for an extended source or other off-nuclear point-sources.The XMM-Newton and NuSTAR spectra agree well and can be described with an absorbed power-law witha photon index Γ = 1.815 ± 0.005 and a fluorescent Fe Kα line in good agreement with literature values.The spectrum does not require a high-energy exponential rollover, with a constraint of Efold > 1 MeV. Athermal Comptonization continuum describes the data well, with parameters that agree with values measuredby INTEGRAL, in particular an electron temperature of kTe ≈ 220 keV, assuming a 10 eV seed photon inputtemperature. We do not find evidence for reflection or a broad iron line and put stringent upper limits ofR <0.01 on the reflection fraction and accretion disk illumination. We use archival Chandra data to estimatethe contribution from diffuse emission, extra-nuclear point-sources, and the X-ray jet to the observed NuSTAR and XMM-Newton X-ray spectra and find the contribution to be negligible. We discuss different scenarios forthe physical origin of the observed X-ray spectrum, and conclude that the inner disk is replaced by an advection-dominatedaccretion flow or that the hard X-rays are dominated by synchrotron self-Compton emission fromthe inner regions of the radio jet or a combination thereof.

We report the first hard X-ray observations with NuSTAR of the BL Lac-type blazar PKS 2155-304, augmented with soft X-ray data from XMM-Newton and γ-ray data from the Fermi Large Area Telescope, obtained in 2013 April when the source was in a very low flux state. A joint NuSTAR and XMM spectrum, covering the energy range 0.5–60 keV, is best described by a model consisting of a log-parabola component with curvature β = 0.3 -0.1+0.2 and a (local) photon index 3.04 ± 0.15 at photon energy of 2 keV, and a hard power-law tail with photon index 2.2 ± 0.4. The hard X-ray tail can be smoothly joined to the quasi-simultaneous γ-ray spectrum by a synchrotron self-Compton component produced by an electron distribution with index p = 2.2. Assuming that the power-law electron distribution extends down to γ min = 1 and that there is one proton per electron, an unrealistically high total jet power of Lp ~ 10^47 erg s^−1 is inferred. This can be reduced by two orders of magnitude either by considering a significant presence of electron–positron pairs with lepton-to-proton ratio ne + e-/np ~ 30, or by introducing an additional, low-energy break in the electron energy distribution at the electron Lorentz factor γbr1 ~ 100. In either case, the jet composition is expected to be strongly matter-dominated.

We report the detection of coherent pulsations from the ultraluminous X-ray source NGC 7793 P13. The ~0.42s nearly sinusoidal pulsations were initially discovered in broadband X-ray observations using XMM-Newton and NuSTAR taken in 2016. We subsequently also found pulsations in archival XMM-Newton data taken in 2013 and 2014. The significant (>>5 sigma) detection of coherent pulsations demonstrates that the compact object in P13 is a neutron star with an observed peak luminosity of ~1e40 erg/s (assuming isotropy), well above the Eddington limit for a 1.4 M_sun accretor. This makes P13 the second ultraluminous X-ray source known to be powered by an accreting neutron star. The pulse period varies between epochs, with a slow but persistent spin up over the 2013-2016 period. This spin-up indicates a magnetic field of B ~ 1.5e12 G, typical of many accreting pulsars. The most likely explanation for the extreme luminosity is a high degree of beaming, however this is difficult to reconcile with the sinusoidal pulse profile., Comment: 6 pages, 3 figures, accepted for publication in ApJL

We present first results from a series of $NuSTAR$ observations of the black hole X-ray binary V404 Cyg obtained during its summer 2015 outburst, primarily focusing on observations during the height of this outburst activity. The $NuSTAR$ data show extreme variability in both the flux and spectral properties of the source. This is partly driven by strong and variable line-of-sight absorption, similar to previous outbursts. The latter stages of this observation are dominated by strong flares, reaching luminosities close to Eddington. During these flares, the central source appears to be relatively unobscured and the data show clear evidence for a strong contribution from relativistic reflection, providing a means to probe the geometry of the innermost accretion flow. Based on the flare properties, analogy with other Galactic black hole binaries, and also the simultaneous onset of radio activity, we argue that this intense X-ray flaring is related to transient jet activity during which the ejected plasma is the primary source of illumination for the accretion disk. If this is the case, then our reflection modelling implies that these jets are launched in close proximity to the black hole (as close as a few gravitational radii), consistent with expectations for jet launching models that tap either the spin of the central black hole, or the very innermost accretion disk. Our analysis also allows us to place the first constraints on the black hole spin for this source, which we find to be $a^* > 0.92$ (99% statistical uncertainty, based on an idealized lamppost geometry)., Comment: 23 pages, 16 figures, accepted for publication in ApJ

We present an analysis of NuSTAR observations of a hard intermediate state of the transient black hole GX 339-4 taken in January 2015. As the source softened significantly over the course of the 1.3 d-long observation we split the data into 21 sub-sets and find that the spectrum of all of them can be well described by a power-law continuum with an additional relativistically blurred reflection component. The photon index increases from ~1.69 to ~1.77 over the course of the observation. The accretion disk is truncated at around 9 gravitational radii in all spectra. We also perform timing analysis on the same 21 individual data sets, and find a strong type-C quasi-periodic oscillation (QPO), which increase in frequency from ~0.68 to ~1.05 Hz with time. The frequency change is well correlated with the softening of the spectrum. We discuss possible scenarios for the production of the QPO and calculate predicted inner radii in the relativistic precession model as well as the global disk mode oscillations model. We find discrepancies with respect to the observed values in both models unless we allow for a black hole mass of ~100 M_sun , which is highly unlikely. We discuss possible systematic uncertainties, in particular with the measurement of the inner accretion disk radius in the relativistic reflection model. We conclude that the combination of observed QPO frequencies and inner accretion disk radii, as obtained from spectral fitting, is difficult to reconcile with current models., Comment: 10 pages, 8 figures; accepted for publication in ApJ

We present a multi-epoch hard X-ray analysis of Cygnus X-1 in its soft state based on four observations with NuSTAR. Despite the basic similarity of the observed spectra, there is clear spectral variability between epochs. To investigate this variability, we construct a model incorporating both the standard disk-corona continuum and relativistic reflection from the accretion disk, based on prior NuSTAR work on Cygnus X-1, and apply this model to each epoch independently. We find excellent consistency for the black hole spin, and the iron abundance of the accretion disk, which are expected to remain constant on observational timescales. In particular, we confirm that Cygnus X-1 hosts a rapidly rotating black hole, 0.93

We present the first observations of quiescent active regions (ARs) using NuSTAR, a focusing hard X-ray telescope capable of studying faint solar emission from high temperature and non-thermal sources. We analyze the first directly imaged and spectrally resolved X-rays above 2~keV from non-flaring ARs, observed near the west limb on 2014 November 1. The NuSTAR X-ray images match bright features seen in extreme ultraviolet and soft X-rays. The NuSTAR imaging spectroscopy is consistent with isothermal emission of temperatures $3.1-4.4$~MK and emission measures $1-8\times 10^{46}$~cm$^{-3}$. We do not observe emission above 5~MK but our short effective exposure times restrict the spectral dynamic range. With few counts above 6~keV, we can place constraints on the presence of an additional hotter component between 5 and 12~MK of $\sim 10^{46}$cm$^{-3}$ and $\sim 10^{43}$ cm$^{-3}$, respectively, at least an order of magnitude stricter than previous limits. With longer duration observations and a weakening solar cycle (resulting in an increased livetime), future NuSTAR observations will have sensitivity to a wider range of temperatures as well as possible non-thermal emission., Comment: 7 page, 5 figures, accepted for publication in ApJL

Arcus will be proposed to the NASA Explorer program as a free-flying satellite mission that will enable high-resolution soft X-ray spectroscopy (8-50) with unprecedented sensitivity – effective areas of >500 sq cm and spectral resolution >2500. The Arcus key science goals are (1) to determine how baryons cycle in and out of galaxies by measuring the effects of structure formation imprinted upon the hot gas that is predicted to lie in extended halos around galaxies, groups, and clusters, (2) to determine how black holes influence their surroundings by tracing the propagation of out-flowing mass, energy and momentum from the vicinity of the black hole out to large scales and (3) to understand how accretion forms and evolves stars and circumstellar disks by observing hot infalling and outflowing gas in these systems. Arcus relies upon grazing-incidence silicon pore X-ray optics with the same 12m focal length (achieved using an extendable optical bench) that will be used for the ESA Athena mission. The focused X-rays from these optics will then be diffracted by high-efficiency off-plane reflection gratings that have already been demonstrated on sub-orbital rocket flights, imaging the results with flight-proven CCD detectors and electronics. The power and telemetry requirements on the spacecraft are modest. The majority of mission operations will not be complex, as most observations will be long (~100 ksec), uninterrupted, and pre-planned, although there will be limited capabilities to observe targets of opportunity, such as tidal disruption events or supernovae with a 3-5 day turnaround. After the end of prime science, we plan to allow guest observations to maximize the science return of Arcus to the community.

OBJECTIVE: The neurobiological mechanisms mediating an increased risk to develop affective disorders remain poorly understood. In a group of individuals with a family history of major depressive (MDD) or bipolar disorder (BD), we investigated the microstructural properties of white matter fiber tracts, that is, cingulum bundle, uncinate fasciculus, anterior limb of the internal capsule, and corpus callosum, that facilitate the communication between brain regions implicated in affective disorders.METHOD: Eighty-nine healthy mono- or dizygotic twins with a co-twin diagnosed with MDD or BD (high-risk) and 57 healthy twins with a co-twin with no familial history of affective disorders (low-risk) were included in a diffusion tensor imaging study.RESULT: The high-risk group showed decreased fractional anisotropy (FA), a measure of water diffusion directionality, and increased radial diffusivity in the anterior region of corpus callosum compared to the low-risk group. This abnormality was not associated with zygosity or type of depressive disorder of co-twin.CONCLUSION: The observed decreased anterior callosal fiber FA in the high-risk group may be indicative of a compromised interhemispheric communication between left and right frontal regions critically involved in mood regulation. Reduced anterior callosal FA may act as a vulnerability marker for affective disorders in individuals at familial risk.

We present a multi-epoch hard X-ray analysis of Cygnus X-1 in its soft state based on four observations with the Nuclear Spectroscopic Telescope Array (NuSTAR). Despite the basic similarity of the observed spectra, there is clear spectral variability between epochs. To investigate this variability, we construct a model incorporating both the standard disk-corona continuum and relativistic reflection from the accretion disk, based on prior work on Cygnus X-1, and apply this model to each epoch independently. We find excellent consistency for the black hole spin and the iron abundance of the accretion disk, which are expected to remain constant on observational timescales. In particular, we confirm that Cygnus X-1 hosts a rapidly rotating black hole, 0.93 ≲ a* ≲ 0.96, in broad agreement with the majority of prior studies of the relativistic disk reflection and constraints on the spin obtained through studies of the thermal accretion disk continuum. Our work also confirms the apparent misalignment between the inner disk and the orbital plane of the binary system reported previously, finding the magnitude of this warp to be ~10°–15°. This level of misalignment does not significantly change (and may even improve) the agreement between our reflection results and the thermal continuum results regarding the black hole spin. The spectral variability observed by NuSTAR is dominated by the primary continuum, implying variability in the temperature of the scattering electron plasma. Finally, we consistently observe absorption from ionized iron at ~6.7 keV, which varies in strength as a function of orbital phase in a manner consistent with the absorbing material being an ionized phase of the focused stellar wind from the supergiant companion star., United States. National Aeronautics and Space Administration (Smithsonian Astrophysical Observatory. Contract SV3-73016)

We present an analysis of Nuclear Spectroscopic Telescope Array observations of a hard intermediate state of the transient black hole GX 339-4 taken in 2015 January. With the source softening significantly over the course of the 1.3 day long observation we split the data into 21 sub-sets and find that the spectrum of all of them can be well described by a power-law continuum with an additional relativistically blurred reflection component. The photon index increases from ∼1.69 to ∼1.77 over the course of the observation. The accretion disk is truncated at around nine gravitational radii in all spectra. We also perform timing analysis on the same 21 individual data sets, and find a strong type-C quasi-periodic oscillation (QPO), which increases in frequency from ∼0.68 to ∼1.05 Hz with time. The frequency change is well correlated with the softening of the spectrum. We discuss possible scenarios for the production of the QPO and calculate predicted inner radii in the relativistic precession model as well as the global disk mode oscillations model. We find discrepancies with respect to the observed values in both models unless we allow for a black hole mass of ~100, which is highly unlikely. We discuss possible systematic uncertainties, in particular with the measurement of the inner accretion disk radius in the relativistic reflection model. We conclude that the combination of observed QPO frequencies and inner accretion disk radii, as obtained from spectral fitting, is difficult to reconcile with current models.

We present NuSTAR spectral and timing studies of the supergiant fast X-ray transient (SFXT) IGR J17544-2619. The spectrum is well described by an ~1 keV blackbody and a hard continuum component, as expected from an accreting X-ray pulsar. We detect a cyclotron line at 17 keV, confirming that the compact object in IGR J17544-2619 is indeed a neutron star. This is the first measurement of the magnetic field in an SFXT. The inferred magnetic field strength, B = (1.45 ± 0.03) × 1012G (1 + z) is typical of neutron stars in X-ray binaries, and rules out a magnetar nature for the compact object. We do not find any significant pulsations in the source on time-scales of 1-2000 s.

Item does not contain fulltext, IMPORTANCE: Cerebral amyloid-beta aggregation is an early pathological event in Alzheimer disease (AD), starting decades before dementia onset. Estimates of the prevalence of amyloid pathology in persons without dementia are needed to understand the development of AD and to design prevention studies. OBJECTIVE: To use individual participant data meta-analysis to estimate the prevalence of amyloid pathology as measured with biomarkers in participants with normal cognition, subjective cognitive impairment (SCI), or mild cognitive impairment (MCI). DATA SOURCES: Relevant biomarker studies identified by searching studies published before April 2015 using the MEDLINE and Web of Science databases and through personal communication with investigators. STUDY SELECTION: Studies were included if they provided individual participant data for participants without dementia and used an a priori defined cutoff for amyloid positivity. DATA EXTRACTION AND SYNTHESIS: Individual records were provided for 2914 participants with normal cognition, 697 with SCI, and 3972 with MCI aged 18 to 100 years from 55 studies. MAIN OUTCOMES AND MEASURES: Prevalence of amyloid pathology on positron emission tomography or in cerebrospinal fluid according to AD risk factors (age, apolipoprotein E [APOE] genotype, sex, and education) estimated by generalized estimating equations. RESULTS: The prevalence of amyloid pathology increased from age 50 to 90 years from 10% (95% CI, 8%-13%) to 44% (95% CI, 37%-51%) among participants with normal cognition; from 12% (95% CI, 8%-18%) to 43% (95% CI, 32%-55%) among patients with SCI; and from 27% (95% CI, 23%-32%) to 71% (95% CI, 66%-76%) among patients with MCI. APOE-epsilon4 carriers had 2 to 3 times higher prevalence estimates than noncarriers. The age at which 15% of the participants with normal cognition were amyloid positive was approximately 40 years for APOE epsilon4epsilon4 carriers, 50 years for epsilon2epsilon4 carriers, 55 years for epsilon3epsilon4 c

We present coordinated multiwavelength observations of the bright, nearby BL Lac object Mrk 421 taken in 2013 January-March, involving GASP-WEBT, Swift, NuSTAR, Fermi-LAT, MAGIC, VERITAS, and other collaborations and instruments, providing data from radio to very-high-energy (VHE) gamma-ray bands. NuSTAR yielded previously unattainable sensitivity in the 3-79 keV range, revealing that the spectrum softens when the source is dimmer until the X-ray spectral shape saturates into a steep power law with a photon index of approximately 3, with no evidence for an exponential cutoff or additional hard components up to about 80 keV. For the first time, we observed both the synchrotron and the inverse-Compton peaks of the spectral energy distribution (SED) simultaneously shifted to frequencies below the typical quiescent state by an order of magnitude. The fractional variability as a function of photon energy shows a double-bump structure which relates to the two bumps of the broadband SED. In each bump, the variability increases with energy which, in the framework of the synchrotron self-Compton model, implies that the electrons with higher energies are more variable. The measured multi-band variability, the significant X-ray-to-VHE correlation down to some of the lowest fluxes ever observed in both bands, the lack of correlation between optical/UV and X-ray flux, the low degree of polarization and its significant (random) variations, the short estimated electron cooling time, and the significantly longer variability timescale observed in the NuSTAR light curves point toward in-situ electron acceleration, and suggest that there are multiple compact regions contributing to the broadband emission of Mrk 421 during low-activity states., Comment: 32 pages, 14 figures; accepted for publication in ApJ

We present initial results and the source catalog from the NuSTAR survey of the Extended Chandra Deep Field South (hereafter, ECDFS) - currently the deepest contiguous component of the NuSTAR extragalactic survey program. The survey covers the full ~30 arcmin x 30 arcmin area of this field to a maximum depth of ~360 ks (~220 ks when corrected for vignetting at 3-24 keV), reaching sensitivity limits of ~1.3 x 10^-14 erg/cm2/s (3-8 keV), ~3.4 x 10^-14 erg/cm2/s (8-24 keV) and ~3.0 x 10^-14 erg/cm2/s (3-24 keV). Fifty four (54) sources are detected over the full field, although five of these are found to lie below our significance threshold once contaminating flux from neighboring (i.e., blended) sources is taken into account. Of the remaining 49 that are significant, 19 are detected in the 8-24 keV band. The 8-24 keV to 3-8 keV band ratios of the twelve sources that are detected in both bands span the range 0.39-1.7, corresponding to a photon index range of Gamma ~ 0.5-2.3, with a median photon index of 1.70 +/- 0.52. The redshifts of the 49 sources in our main sample span the range z = 0.21-2.7, and their rest-frame 10-40 keV luminosities (derived from the observed 8-24 keV fluxes) span the range L(10-40 keV) ~ (0.7-300) x 10^43 erg/s, sampling below the "knee" of the X-ray luminosity function out to z ~ 0.8-1. Finally, we identify one NuSTAR source that has neither a Chandra nor an XMM-Newton counterpart, but that shows evidence of nuclear activity at infrared wavelengths, and thus may represent a genuine, new X-ray source detected by NuSTAR in the ECDFS., Comment: 20 pages, published in the Astrophysical Journal

We present the 3-8 keV and 8-24 keV number counts of active galactic nuclei (AGN) identified in the NuSTAR extragalactic surveys. NuSTAR has now resolved 33-39% of the X-ray background in the 8-24 keV band, directly identifying AGN with obscuring columns up to approximately 1e25 /cm2. In the softer 3-8 keV band the number counts are in general agreement with those measured by XMM-Newton and Chandra over the flux range 5e-15 < S(3 - 8 keV)/(erg/cm2/s) < 1e-12 probed by NuSTAR. In the hard 8-24 keV band NuSTAR probes fluxes over the range 2e-14 < S(8-24 keV)/(erg/cm2/s) < 1e-12, a factor of approximately 100 fainter than previous measurements. The 8-24 keV number counts match predictions from AGN population synthesis models, directly confirming the existence of a population of obscured and/or hard X-ray sources inferred from the shape of the integrated cosmic X-ray background. The measured NuSTAR counts lie significantly above simple extrapolation with a Euclidian slope to low flux of the Swift/BAT 15-55 keV number counts measured at higher fluxes S(15-55 keV) > 1e-11 erg/cm2/s, reflecting the evolution of the AGN population between the Swift/BAT local (z<0.1) sample and NuSTAR's z~1 sample. CXB synthesis models, which account for AGN evolution, lie above the Swift/BAT measurements, suggesting that they do not fully capture the evolution of obscured AGN at low redshifts., Comment: 8 pages; accepted by the Astrophysical Journal

To provide the census of the sources contributing to the X-ray background peak above 10 keV, NuSTAR is performing extragalactic surveys using a three-tier "wedding cake" approach. We present the NuSTAR survey of the COSMOS field, the medium sensitivity and medium area tier, covering 1.7 deg2 and overlapping with both Chandra and XMM-Newton data. This survey consists of 121 observations for a total exposure of ~3 Ms. To fully exploit these data, we developed a new detection strategy, carefully tested through extensive simulations. The survey sensitivity at 20% completeness is 5.9, 2.9 and 6.4 x 10^-14 erg/cm2/s in the 3-24 keV, 3-8 keV and 8-24 keV bands, respectively. By combining detections in 3 bands, we have a sample of 91 NuSTAR sources with 10^42 -10^45.5 erg/s luminosities and redshift z=0.04-2.5. Thirty two sources are detected in the 8-24 keV band with fluxes ~100 times fainter than sources detected by Swift-BAT. Of the 91 detections, all but four are associated with a Chandra and/or XMM-Newton point-like counterpart. One source is associated with an extended lower energy X-ray source. We present the X-ray (hardness ratio and luminosity) and optical-to-X-ray properties. The observed fraction of candidate Compton-thick AGN measured from the hardness ratio is between 13-20%. We discuss the spectral properties of NuSTAR J100259+0220.6 (ID 330) at z=0.044, with the highest hardness ratio in the entire sample. The measured column density exceeds 10^24 /cm2, implying the source is Compton-thick. This source was not previously recognized as such without the >10 keV data., Comment: 20 pages, published in the Astrophysical Journal

We present a NuSTAR and XMM-Newton monitoring campaign in 2014/2015 of the Compton-thick Seyfert 2 galaxy, NGC 1068. During the August 2014 observation, we detect with NuSTAR a flux excess above 20 keV ($32\pm6 \%$) with respect to the December 2012 observation and to a later observation performed in February 2015. We do not detect any spectral variation below 10 keV in the XMM-Newton data. The transient excess can be explained by a temporary decrease of the column density of the obscuring material along the line of sight (from N$_{\rm H}\simeq10^{25}$ cm$^{-2}$ to N$_{\rm H}=6.7\pm1.0\times10^{24}$ cm$^{-2}$), which allows us for the first time to unveil the direct nuclear radiation of the buried AGN in NGC 1068 and to infer an intrinsic 2-10 keV luminosity L$_{\rm X}=7^{+7}_{-4} \times 10^{43}$ erg s$^{-1}$., Comment: 5 pages, 3 figures, accepted for publication on MNRAS letters

We present simultaneous XMM-Newton and NuSTAR observations spanning 3-78 keV of the nearest radio galaxy, Centaurus A (Cen A). The accretion geometry around the central engine in Cen A is still debated, and we investigate possible configurations using detailed X-ray spectral modeling. NuSTAR imaged the central region of Cen A with sub-arcminute resolution at X-ray energies above 10 keV for the first time, but finds no evidence for an extended source or other off-nuclear point-sources. The XMM-Newton and NuSTAR spectra agree well and can be described with an absorbed power-law with a photon index {\Gamma} = 1.815 +/- 0.005 and a fluorescent Fe K{\alpha} line in good agreement with literature values. The spectrum does not require a high-energy exponential rollover, with a constraint of E_fold > 1 MeV. A thermal Comptonization continuum describes the data well, with parameters that agree with values measured by INTEGRAL, in particular an electron temperature kTe between ~100-300 keV, seed photon input temperatures between 5-50 eV. We do not find evidence for reflection or a broad iron line and put stringent upper limits of R < 0.01 on the reflection fraction and accretion disk illumination. We use archival Chandra data to estimate the contribution from diffuse emission, extra-nuclear point-sources, and the outer X-ray jet to the observed NuSTAR and XMM-Newton X-ray spectra and find the contribution to be negligible. We discuss different scenarios for the physical origin of the observed hard X-ray spectrum, and conclude that the inner disk is replaced by an advection-dominated accretion flow or that the X-rays are dominated by synchrotron self-Compton emission from the inner regions of the radio jet or a combination thereof., Comment: 13 pages, 6 figures, accepted for publication in ApJ

We present spectral analysis of five NuSTAR and Swift observations of GX 339-4 taken during a failed outburst in summer 2013. These observations cover Eddington luminosity fractions in the range ~0.9-6%. Throughout this outburst, GX 339-4 stayed in the hard state, and all five observations show similar X-ray spectra with a hard power-law with a photon index near 1.6 and significant contribution from reflection. Using simple reflection models we find unrealistically high iron abundances. Allowing for different photon indices for the continuum incident on the reflector relative to the underlying observed continuum results in a statistically better fit and reduced iron abundances. With a photon index around 1.3, the input power-law on the reflector is significantly harder than that which is directly observed. We study the influence of different emissivity profiles and geometries and consistently find an improvement when using separate photon indices. The inferred inner accretion disk radius is strongly model dependent, but we do not find evidence for a truncation radius larger than 100 r_g in any model. The data do not allow independent spin constraints but the results are consistent with the literature (i.e., a>0). Our best-fit models indicate an inclination angle in the range 40-60 degrees, consistent with limits on the orbital inclination but higher than reported in the literature using standard reflection models. The iron line around 6.4 keV is clearly broadened, and we detect a superimposed narrow core as well. This core originates from a fluorescence region outside the influence of the strong gravity of the black hole and we discuss possible geometries., Comment: 11 pages, 6 figures, 6 tables, plus 9 tables in the appendix. Submitted to ApJ

We report the results of a multi-band observing campaign on the famous blazar 3C 279 conducted during a phase of increased activity from 2013 December to 2014 April, including first observations of it with NuSTAR. The $\gamma$-ray emission of the source measured by Fermi-LAT showed multiple distinct flares reaching the highest flux level measured in this object since the beginning of the Fermi mission, with $F(E > 100\,{\rm MeV})$ of $10^{-5}$ photons cm$^{-2}$ s$^{-1}$, and with a flux doubling time scale as short as 2 hours. The $\gamma$-ray spectrum during one of the flares was very hard, with an index of $\Gamma_\gamma = 1.7 \pm 0.1$, which is rarely seen in flat spectrum radio quasars. The lack of concurrent optical variability implies a very high Compton dominance parameter $L_\gamma/L_{\rm syn} > 300$. Two 1-day NuSTAR observations with accompanying Swift pointings were separated by 2 weeks, probing different levels of source activity. While the 0.5$-$70 keV X-ray spectrum obtained during the first pointing, and fitted jointly with Swift-XRT is well-described by a simple power law, the second joint observation showed an unusual spectral structure: the spectrum softens by $\Delta\Gamma_{\rm X} \simeq 0.4$ at $\sim$4 keV. Modeling the broad-band SED during this flare with the standard synchrotron plus inverse Compton model requires: (1) the location of the $\gamma$-ray emitting region is comparable with the broad line region radius, (2) a very hard electron energy distribution index $p \simeq 1$, (3) total jet power significantly exceeding the accretion disk luminosity $L_{\rm j}/L_{\rm d} \gtrsim 10$, and (4) extremely low jet magnetization with $L_{\rm B}/L_{\rm j} \lesssim 10^{-4}$. We also find that single-zone models that match the observed $\gamma$-ray and optical spectra cannot satisfactorily explain the production of X-ray emission., Comment: 17 pages, 10 figures, accepted for publication in The Astrophysical Journal

We present the first broadband 0.3-25.0 kev X-ray observations of the bright ultraluminous X-ray source (ULX) Holmberg II X-1, performed by NuSTAR, XMM-Newton and Suzaku in September 2013. The NuSTAR data provide the first observations of Holmberg II X-1 above 10 keV, and reveal a very steep high-energy spectrum, similar to other ULXs observed by NuSTAR to date. These observations further demonstrate that ULXs exhibit spectral states that are not typically seen in Galactic black hole binaries. Comparison with other sources implies that Holmberg II X-1 accretes at a high fraction of its Eddington accretion rate, and possibly exceeds it. The soft X-ray spectrum (E<10 keV) appears to be dominated by two blackbody-like emission components, the hotter of which may be associated with an accretion disk. However, all simple disk models under-predict the NuSTAR data above ~10 keV and require an additional emission component at the highest energies probed, implying the NuSTAR data does not fall away with a Wien spectrum. We investigate physical origins for such an additional high-energy emission component, and favor a scenario in which the excess arises from Compton scattering in a hot corona of electrons with some properties similar to the very-high state seen in Galactic binaries. The observed broadband 0.3-25.0 keV luminosity inferred from these epochs is Lx = (8.1+/-0.1)e39 erg/s, typical for Holmberg II X-1, with the majority of the flux (~90%) emitted below 10 keV., Comment: 8 pages, 2 figures, accepted for publication in ApJ

We present the results from coordinated X-ray observations of the ultraluminous X-ray source NGC 5204 X-1 performed by NuSTAR and XMM-Newton in early 2013. These observations provide the first detection of NGC 5204 X-1 above 10 keV, extending the broadband coverage to 0.3-20 keV. The observations were carried out in two epochs separated by approximately 10 days, and showed little spectral variation, with an observed luminosity of Lx = (4.95+/-0.11)e39 erg/s. The broadband spectrum confirms the presence of a clear spectral downturn above 10 keV seen in some previous observations. This cutoff is inconsistent with the standard low/hard state seen in Galactic black hole binaries, as would be expected from an intermediate mass black hole accreting at significantly sub-Eddington rates given the observed luminosity. The continuum is apparently dominated by two optically thick thermal-like components, potentially accompanied by a faint high energy tail. The broadband spectrum is likely associated with an accretion disk that differs from a standard Shakura & Sunyaev thin disk., Comment: 7 pages, 5 figures. Accepted for publication in ApJ

IMPORTANCE: Cerebral amyloid-β aggregation is an early pathological event in Alzheimer disease (AD), starting decades before dementia onset. Estimates of the prevalence of amyloid pathology in persons without dementia are needed to understand the development of AD and to design prevention studies. OBJECTIVE: To use individual participant data meta-analysis to estimate the prevalence of amyloid pathology as measured with biomarkers in participants with normal cognition, subjective cognitive impairment (SCI), or mild cognitive impairment (MCI). DATA SOURCES: Relevant biomarker studies identified by searching studies published before April 2015 using the MEDLINE and Web of Science databases and through personal communication with investigators. STUDY SELECTION: Studies were included if they provided individual participant data for participants without dementia and used an a priori defined cutoff for amyloid positivity. DATA EXTRACTION AND SYNTHESIS: Individual records were provided for 2914 participants with normal cognition, 697 with SCI, and 3972 with MCI aged 18 to 100 years from 55 studies. MAIN OUTCOMES AND MEASURES: Prevalence of amyloid pathology on positron emission tomography or in cerebrospinal fluid according to AD risk factors (age, apolipoprotein E [APOE] genotype, sex, and education) estimated by generalized estimating equations. RESULTS: The prevalence of amyloid pathology increased from age 50 to 90 years from 10% (95% CI, 8%-13%) to 44% (95% CI, 37%-51%) among participants with normal cognition; from 12% (95% CI, 8%-18%) to 43% (95% CI, 32%-55%) among patients with SCI; and from 27% (95% CI, 23%-32%) to 71% (95% CI, 66%-76%) among patients with MCI. APOE-ε4 carriers had 2 to 3 times higher prevalence estimates than noncarriers. The age at which 15% of the participants with normal cognition were amyloid positive was approximately 40 years for APOE ε4ε4 carriers, 50 years for ε2ε4 carriers, 55 years for ε3ε4 carriers, 65 years for ε3ε3 carriers, and 95 y

Sex-hormone fluctuations may increase risk for developing depressive symptoms and alter emotional processing as supported by observations in menopausal and pre- to postpartum transition. In this double-blinded, placebo-controlled study, we used blood-oxygen level dependent functional magnetic resonance imaging (fMRI) to investigate if sex-steroid hormone manipulation with a gonadotropin-releasing hormone agonist (GnRHa) influences emotional processing. Fifty-six healthy women were investigated twice: at baseline (follicular phase of menstrual cycle) and 16 ± 3 days post intervention. At both sessions, fMRI-scans during exposure to faces expressing fear, anger, happiness or no emotion, depressive symptom scores and estradiol levels were acquired. The fMRI analyses focused on regions of interest for emotional processing. As expected, GnRHa initially increased and subsequently reduced estradiol to menopausal levels, which was accompanied by an increase in subclinical depressive symptoms relative to placebo. Women who displayed larger GnRHa-induced increase in depressive symptoms had a larger increase in both negative and positive emotion-elicited activity in the anterior insula. When considering the post-GnRHa scan only, depressive responses were associated with emotion-elicited activity in the anterior insula and amygdala. The effect on regional activity in anterior insula was not associated with the estradiol net decline, only by the GnRHa-induced changes in mood. Our data implicate enhanced insula recruitment during emotional processing in the emergence of depressive symptoms following sex-hormone fluctuations. This may correspond to the emotional hypersensitivity frequently experienced by women postpartum.