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Despite microRNA-494 (miR-494) has a well-established role in many types of cancer; the biological function and potential mechanism of miR-494 in human osteosarcoma (OS) has not been elucidated. The aim of this study was therefore to investigate the role and underlying mechanism of miR-494 expression in osteosarcoma. Here, we found that miR-494 was significantly decreased in OS tissues and cell lines compared to the adjacent noncancerous bone tissues (P

Heating capacity of general air-condition system at low ambient temperature has been heavily attenuated. To solve the problem stated, the variable speed Scroll compressor with enhanced vapor injection (EVI) becomes the focus of the study in recent years. Influencing factors of the capacity and energy efficiency of the scroll compressor with EVI technology have been introduced in paper, including the area of Supplementary channel, the parameters of orbiting and fixed scroll profile, the position and number of Supplementary inlet. The different scheme of prototype is tested and the effect of the scheme is compared and analyzed. With the vapor injected into compress chambers, the Gas forces of working chambers change, and the characteristics of gas force about the scroll compressor with EVI Technology have also been analyzed.

Peasant household's credit behavior not only affect the financial ability of the peasant household, but also influence the credit decisions of the rural financial institution, consequently impact on the development of the Chinese rural economic and the peasant household economic. This paper, based on the credit behavior of peasant household in the process of the Chinese rural economic development11Peasant household's credit behavior is the credit behavior under the comprehensive influence of the repayment capacity and willingness, in which repayment capacity is the key element., analysis the credit behavior game in rural credit and loan process between peasant households and rural financial institution, and the game among peasant households in rural joint warrant process. Finally, provides methods to improve the credit behavior of peasant household in credit game.

The dynamic processes of NO reduction by coals and char at different O2 concentrations have been investigated under the suspension conditions of a precalciner. The effects of cement raw meal, tempe...

Materials with perpendicular magnetic anisotropy have been intensively investigated due to their potential applications in the nonvolatile magnetic memory and spin-torque oscillators. Hear in this paper, we report a special interesting spin-transfer-driven magnetic behavior in perpendicularly magnetized (Co/Ni) -based spin-valve nano-pillars due to the reduced symmetry of easy axis in the free layer. The micromagnetic simulations indicate that a dip in the average magnetization curve can take place due to the reduced symmetry such as tilt of the magnetic field as well as the easy axis of the free and polarizer layers. In order to further clarify the physics mechanism of the dip, we carry out a series of new simulation studies. In our simulations, we consider a spin-valve nano-pillar with perpendicular anisotropy free layer and a 3 tilted polarizer layer. A negative perpendicular magnetic field and a positive perpendicular current are both applied simultaneously. In the average magnetization curves mz as a function of the magnetic field with various currents, three dips are observed. Note that although the spin-transfer torque is essential to the appearance of the dips, the position of the dips is less affected by the current in a certain current range. For three dips, we notice that the mz values are almost identical at a special magnetic field for different currents. At this special magnetic field, the magnetization oscillation modes in the free layer are similar to each other for different currents. The corresponding frequency spectra show that the amplitude of the main frequency peak decreases with the increasing of current due to the enhanced spin-transfer torque. In addition, the frequency shows a blue-shift with the increasing of applied current. Our simulations show that the main frequency f1 corresponding to the highest peak is approximately equal to the precession frequency of the local magnetization in the free layer. Several high-order frequency peaks are also observed in the frequency spectrum with fn=nf1, where n is an integer. Therefore the periodic oscillation of mz is a harmonic oscillation. Further simulations indicate that the dip appearance is also affected by the thickness of free layer. The spin-transfer torque effect decreases with the thickness of the free layer increasing. As a consequence, the dips shift to a low magnetic field range with the increase of the thickness. And for larger thickness t=8.0 nm, no dip appears. This result suggests that the spin-transfer torque is necessary for the dip, rather than the unique effect factor, to occur. In the dip region, the magnetic oscillation modes of the free layer show interesting frequency spectrum characters:harmonic frequency or inter-harmonic frequency. As a consequence, the periodic oscillation of the free layer is accompanied by the harmonic waves.

The study investigated whether bradykinin (BK) preconditioning could regulate the expression of aquaporin-4 (AQP4) using an in vivo transient spinal cord ischemia model in rats. BK was infused continuously via the left femoral artery with infusion pump for 15 min (10 microg/kg/min) then we induced ischemia for 20 min and reperfusion for 24 and 72 h respectively. The results demonstrated that the central part of the white matter exhibited loss of perivascular AQP4 and showed a partial recovery toward 72 h of reperfusion. The border zone of white matter was different from the central part of the white matter by showing no loss of perivascular AQP4 at 24 h of reperfusion but rather a slight increase. BK significantly reduced the expression level of AQP4 protein in the white matter, but it had none of this effect in the gray matter region at 72 h post-reperfusion. There was no difference in AQP4 protein levels between BK group and control group at the two above-mentioned spinal cord regions at 24 h after reperfusion. In addition, the changes in AQP4 protein induced by BK preconditioning were obvious at 72 h after reperfusion, which were accompanied by a reduction of spinal cord edema. Our results demonstrated that the expression of AQP4 protein after spinal cord ischemia/reperfusion was region-specific, time-dependent and also indicated that the attenuation of AQP4 expression induced by BK could be one of the important molecular mechanisms in physiopathology of spinal cord ischemic edema.