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1,422 results on '"Lo Muzio, L."'

355. p63 expression in odontogenic cysts

Author

Lo Muzio, L., primary, Santarelli, A., additional, Caltabiano, R., additional, Rubini, C., additional, Pieramici, T., additional, Fior, A., additional, Trevisiol, L., additional, Carinci, F., additional, Leonardi, R., additional, Bufo, P., additional, Lanzafame, S., additional, and Piattelli, A., additional

Published
2005
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359. Number 1 Epithelial biology

Author

Scully, C, primary, Bagan, J‐V, additional, Black, M, additional, Carrozzo, M, additional, Eisen, D, additional, Escudier, M, additional, Farthing, P, additional, Kuffer, R, additional, Lo Muzio, L, additional, Mignogna, M, additional, and Porter, SR, additional

Published
2005
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361. Squamous Cell Carcinoma of the Lower LIP: Fas/Fasl Expression, Lymphocyte Subtypes and Outcome

Author

Somma, P., primary, Lo Muzio, L., additional, Mansueto, G., additional, Delfino, M., additional, Fabbrocini, G., additional, Mascolo, M., additional, Mignogna, C., additional, Di Benedetto, M., additional, Carinci, F., additional, De Lillo, A., additional, Pastore, L., additional, Serpico, R., additional, De Rosa, G., additional, and Staibano, S., additional

Published
2005
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378. p120cat delocalization in cell lines of oral cancer

Author

Lo Muzio, L., primary, Pannone, G., additional, Staibano, S., additional, Mignogna, M.D., additional, Serpico, R., additional, Fanali, S., additional, De Rosa, G., additional, Piattelli, A., additional, and Mariggiò, M.A., additional

Published
2002
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381. British Dental Journal

Author

Hasegawa, A, primary, Kawaguchi, S, additional, Kuc, I, additional, Peters, E, additional, Mignona, M, additional, Lo Muzio, L, additional, Williams, S, additional, and Kwan, S, additional

Published
2000
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388. Correspondence

Author

Testa Nf, Giuseppe Pannone, Stefania Staibano, Mignogna, and Lo Muzio L

Subjects
Cancer Research, Pathology, medicine.medical_specialty, Oncology, business.industry, Myofibroma, Medicine, Oral Surgery, Differential diagnosis, business, Fibrosarcoma, medicine.disease, Myofibromatosis
Published
2000
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394. CD3 AND CD20 EXPRESSION IN TITANIUM vs ZIRCONIA PERI-IMPLANT SOFT TISSUES: A HUMAN STUDY.

Author

BAMBINI, F., SANTARELLI, A., MARZO, G., RUBINI, C., ORSINI, G., DI IORIO, D., LO RUSSO, L., and LO MUZIO, L.

Subjects
PERI-implantitis, GENE expression, IMMUNOHISTOCHEMISTRY, T cells, BIOMATERIALS, METALS in medicine, INFLAMMATION, TISSUE analysis
Abstract

The aim of this study was to investigate the presence of an inflammatory infiltrate in the peri-implant soft tissue of single-implant crowns supported by either zirconia or titanium abutments in healthy subjects. Serial sections from formalin-fixed, paraffin-embedded blocks from peri-implant mucosa of 25 patients were immunohistochemically analyzed for CD3 and CD20 lymphocyte marker expression. The results showed that levels of T cells (CD3) were higher around zirconia than titanium abutments (p<0.05). On the contrary, the levels of B cells (CD20) were found higher around titanium abutment in comparison with the zirconia abutment. These differences were statistically significant (p<0.05). [ABSTRACT FROM AUTHOR]

Published
2013
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395. Immunohistochemical correlation between microvessel density and lymphoid infiltrate in radicular cysts.

Author

Zizzi, A, Aspriello, SD, Ferrante, L, Stramazzotti, D, Colella, G, Balercia, P, Lo Muzio, L, Piemontese, M, Goteri, G, and Rubini, C

Subjects
ACADEMIC medical centers, CYSTS (Pathology), IMMUNOGLOBULINS, IMMUNOHISTOCHEMISTRY, LYMPHATICS, MICROCIRCULATION, ROOT canal treatment, STATISTICS, DENTAL pathology, DATA analysis software, DESCRIPTIVE statistics, DISEASE complications
Abstract

Oral Diseases (2012) 19, 92-99 Objective: Radicular cysts occur as a result of the immunological response to continuous antigenic stimulation from root canals. We correlated the immunophenotypical composition of the lymphoid infiltrate to the microvessel density expressed by the count of CD34 reactive endothelial cells in radicular cysts. Subjects and methods: Thirty-four cases of radicular cysts were evaluated by immunohistochemistry, using antibodies against B- and T-cell antigens (CD20, CD3, CD4, CD8) and against the endothelial cell marker CD34. Statistical analysis was performed. Results: In the epithelium, we observed a low amount of lymphoid infiltrate in all 34 radicular cysts, and a strong significant negative correlation between T and B lymphocytes and between T-helper and T-cytotoxic/suppressor lymphocytes. In the cyst capsule, we observed a significant positive correlation between B and T lymphocytes, B and T-cytotoxic/suppressor lymphocytes, T and T-helper lymphocytes and between the number of CD34+ blood vessels and T and T-helper lymphocytes, respectively. We observed a statistically significant correlation between percentage of CD34+ vessels and inflammatory infiltrate grade. Conclusions: Both humoral and cellular immune reactions and neovascularization are likely to occur in the complex events of tissue destruction. The inflammatory infiltrate has an important role in neoangiogenesis and consequently in radicular cysts development and growth. [ABSTRACT FROM AUTHOR]

Published
2013
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396. SALIVARY PROTEOMIC SIGNATURES OF ORAL SQUAMOUS CELL CARCINOMA.

Author

LO RUSSO, L., PAPALE, M., PERRONE, D., RANIERI, E., RUBINI, C., GIANNATEMPO, G., SANTARELLI, A., COLELLA, G., and LO MUZIO, L.

Subjects
PROTEOMICS, SQUAMOUS cell carcinoma, MORTALITY, MOUTH examination, BIOMARKERS, MULTIVARIATE analysis, DISEASE progression, CANCER, DIAGNOSIS
Abstract

Delay in diagnosing oral squamous cell carcinoma (OSCC) can be still identified as a major cause of its high morbidity and mortality. To date, the early diagnosis for OSCC is mainly based on clinical oral examination and there is an urgent need for reliable markers; thus, advancements in molecular technologies has set the stage for investigating new markers, as well as new diagnostic matrices. The aim of the present study is to investigate the presence of proteomic signatures of OSCC in saliva and their use as potential biomarkers for early and non-invasive diagnosis. Saliva from 45 OSCC patients and 30 healthy controls was analysed by SELDI-TOF mass spectrometry and ProteinChip® technology. A supervised multivariate statistical analysis (Classification and Regression Tree - CART) was used to build models for discriminating between OSCC and controls, and between early (ES-OSCC) and late stage (LS-OSCC) cancers. The peptide with 8041 Da mass was 22-fold more expressed in OSCC, thus being a suitable potential biomarker. Classification and regression analysis allowed to build a model that was capable of correctly classifying all cancers and controls in an independent testing set, using the 8041 m/z peak as splitter. Eleven peaks were also differently expressed between ES-OSCCand LS-OSCC, but, basing on these differences, it was not possible to build an algorithm to predict tumour staging. These findings confirm that saliva proteome in OSCC patients is different from healthy controls and these variations might reflect different stages of disease progression and are worthy of further validation as diagnostic and prognostic biomarkers. [ABSTRACT FROM AUTHOR]

Published
2012
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400. MMP-13 expression in keratocyst odontogenic tumour associated with NBCCS and sporadic keratocysts.

Author

Leonardi, R, Matthews, JB, Caltabiano, R, Greco, M, Lombardo, C, Loreto, C, Santarelli, A, and Lo Muzio, L

Subjects
ORAL surgery, DISEASE relapse prevention, CHI-squared test, COMPUTER software, ENZYMES, FISHER exact test, IMMUNOHISTOCHEMISTRY, DATA analysis, ODONTOGENIC cysts, EQUIPMENT & supplies, SEVERITY of illness index, CLASSIFICATION, THERAPEUTICS
Abstract

Oral Diseases (2010) 16, 795-800 Objective: To investigate the matrix metalloproteinase (MMP)-13 expression in associated and non-nevoid basal cell carcinoma syndrome (NBCCS) Odontogenic Keratocysts (OCKs) in order to contribute to a better understanding of the differences in the growth pattern between them. Materials and methods: Thirty-nine paraffin-embedded blocks of OCKs, 26 sporadic OCKs and 11 NBCCS-associated KCOTs were studied by immunohistochemistry to evaluate MMP-13 expression both in epithelial and stromal layers. A semi-quantitative scale was used to evaluate immunostaining. Obtained data were compared between the two groups, using Fischer's exact test and the chi-square test. Results: Only 13 of 26 sporadic OCKs showed a positive immunostaining, whilst 11 KCOTs resulted in positive labelling for MMP-13 expression. Moreover, syndromic cysts displayed a more intense and diffuse MMP-13 labelling of the stromal tissue. Instead, in non-syndromic forms, the staining pattern of MMP-13 in stromal tissue was completely absent. Fisher's exact test showed a statistically significant greater prevalence of KCOTs-immunolabelled cysts with respect to sporadic OCKs. Conclusions: Results from this study point out that the biological behaviour of these cysts could be related not only to the epithelial layer but also to stromal tissue in that... MMP-13 overexpression in stromal tissue of NBCCS-associated KCOTs could clarify the higher aggressiveness of these cysts. [ABSTRACT FROM AUTHOR]

Published
2010
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