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2,645 results on '"Lim, In Seok"'

354. Early Bactericidal Activity of Delpazolid (LCB01-0371) in Patients with Pulmonary Tuberculosis

Author

Kim, Ju Sang, primary, Kim, Yong-hyun, additional, Lee, Sang Haak, additional, Kim, Yee Hyung, additional, Kim, Jin-woo, additional, Kang, Ji Young, additional, Kim, Sung Kyoung, additional, Kim, Seung Joon, additional, Kang, Yun-Seong, additional, Kim, Tae-hyung, additional, Mok, Jeongha, additional, Byun, Min Kwang, additional, Park, Hye Jung, additional, Joh, Joon-sung, additional, Park, Yong Bum, additional, Lim, Hyeong-Seok, additional, Choi, Hongjo, additional, Lee, Seung Heon, additional, Kim, Hyejin, additional, Yang, Jeongseong, additional, Kim, Hyunji, additional, Shen, Xianlin, additional, Alsultan, Abdullah, additional, Cho, InSook, additional, Geiter, Lawrence, additional, and Shim, Tae Sun, additional

Published
2022
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358. Exogenous putrescine attenuates the negative impact of drought stress by modulating physio-biochemical traits and gene expression in sugar beet (Beta vulgaris L.)

Author

Islam, Md Jahirul, primary, Uddin, Md Jalal, additional, Hossain, Mohammad Anwar, additional, Henry, Robert, additional, Begum, Mst. Kohinoor, additional, Sohel, Md. Abu Taher, additional, Mou, Masuma Akter, additional, Ahn, Juhee, additional, Cheong, Eun Ju, additional, and Lim, Young-Seok, additional

Published
2022
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362. Crosslinked Polyethyleneimine Gel Polymer Interface to Improve Cycling Stability of RFBs

Author

Lim, Hyung-Seok, primary, Chae, Sujong, additional, Yan, Litao, additional, Li, Guosheng, additional, Feng, Ruozhu, additional, Shin, Yongsoon, additional, Nie, Zimin, additional, Sivakumar, Bhuvaneswari Modachur, additional, Zhang, Xin, additional, Liang, Yangang, additional, Bazak, David Jonathan, additional, Shutthanandan, Vaithiyalingam, additional, Murugesan, Vijayakumar, additional, Kim, Soowhan, additional, and Wang, Wei, additional

Published
2022
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382. Characterization of interval graphs that are paired 2-disjoint path coverable.

Author

Park, Jung-Heum and Lim, Hyeong-Seok

Subjects
*PARALLEL processing, *SUPERCOMPUTERS
Abstract

The performance of a supercomputing system is significantly affected by the network used to interconnect the nodes. One of the key problems associated with parallel processing is finding disjoint paths in the underlying graph of an interconnection network. It is often important to find disjoint paths that collectively pass through all the vertices. A disjoint path cover of a graph is a set of vertex-disjoint paths that altogether cover every vertex of the graph. Given disjoint source and sink sets, S = { s 1 , ... , s k } and T = { t 1 , ... , t k } , in a graph, a paired k-disjoint path cover joining S and T is a disjoint path cover { P 1 , ... , P k } composed of k paths, in which each path P i runs from s i to t i . In this paper, we characterize interval graphs that have a paired 2-disjoint path cover joining S and T for any possible configurations of source and sink sets S and T of size 2 each. [ABSTRACT FROM AUTHOR]

Published
2023
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383. Pharmacokinetic and Pharmacodynamic Modeling and Simulation Analysis of Prasugrel in Healthy Male Volunteers.

Author

Kim, Mi‐Jo, Kim, Hyungsub, Lee, Sang‐Min, Choi, Hee‐Youn, Kim, Yo‐Han, Choi, Seung Chan, Kim, Eun‐Hwa, Park, Hyun‐Jung, and Lim, Hyeong‐Seok

Subjects
BLOOD platelet aggregation, PHARMACOKINETICS, ORAL drug administration, PRASUGREL, PLATELET aggregation inhibitors, VOLUNTEERS
Abstract

This study evaluated the pharmacokinetics and pharmacodynamics of the antiplatelet agent prasugrel, and explored its optimal dose regimens via modeling and simulation using NONMEM. We measured platelet aggregation and the serial plasma concentrations of the inactive (R‐95913) and active metabolites (R‐138727) of prasugrel after a single oral dose of 10–60 mg in 20 healthy adult male volunteers. A pharmacokinetic model for R‐95913 and R‐138727, and a pharmacodynamic model between the concentration of R‐138727 and maximal platelet aggregation measured by light transmittance were constructed. The predictability of the model for platelet aggregation was evaluated by comparing the model prediction values with the observed ones not used in the construction of the model. Pharmacokinetic data were best described by a 3‐compartment models for R‐95913, a 1‐compartment model for R‐138727 with transit compartment model for absorption delay, and first‐pass metabolic conversion of R‐95913 into R‐138727 during absorption. The association–dissociation model between R‐138727 and its receptor in platelets was applied for the inhibitory effect of prasugrel on platelet aggregation. Prasugrel rapidly inhibited platelet aggregation after oral administration, with a prolonged duration of action; however, the concentration of the active metabolite decreased rapidly, which may have been due to the slow dissociation rate of R‐138727 from its target receptor in platelets. The external validation suggests that our model could be used to individualize prasugrel treatment in various clinical situations. Simulation showed rapid onset of inhibitory effect with great magnitude and consistent inhibition after therapeutic dose of prasugrel. [ABSTRACT FROM AUTHOR]

Published
2023
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399. Automated Detection of Acute Myocardial Infarction Using Asynchronous Electrocardiogram Signals—Preview of Implementing Artificial Intelligence With Multichannel Electrocardiographs Obtained From Smartwatches: Retrospective Study

Author

Han, Changho, primary, Song, Youngjae, additional, Lim, Hong-Seok, additional, Tae, Yunwon, additional, Jang, Jong-Hwan, additional, Lee, Byeong Tak, additional, Lee, Yeha, additional, Bae, Woong, additional, and Yoon, Dukyong, additional

Published
2021
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