1,985 results on '"Konrad, M."'
Search Results
352. Tubuläre Störungen
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Klaus, G., primary, Konrad, M., additional, Ehrich, J. H. H., additional, and Seyberth, H.-J., additional
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- 2004
- Full Text
- View/download PDF
353. Probability of Bladder Augmentation, Diversion and Clean Intermittent Catheterization in Classic Bladder Exstrophy: A 36-Year, Multi-Institutional, Retrospective Cohort Study
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Benjamin Whittam, Brian A. VanderBrink, Patricio C. Gargollo, Molly Fuchs, Konrad M. Szymanski, Daryl J. McLeod, Andrew C. Strine, Ilina Rosoklija, and Elizabeth B. Yerkes
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Male ,Reoperation ,medicine.medical_specialty ,Adolescent ,Urology ,medicine.medical_treatment ,Urinary Bladder ,Urinary Diversion ,urologic and male genital diseases ,Urologic Surgical Procedure ,Urinary catheterization ,Young Adult ,medicine ,Humans ,Intermittent Urethral Catheterization ,Child ,Probability ,Retrospective Studies ,business.industry ,Urinary diversion ,Bladder Exstrophy ,Age Factors ,Infant, Newborn ,Infant ,Retrospective cohort study ,Clean Intermittent Catheterization ,Plastic Surgery Procedures ,medicine.disease ,female genital diseases and pregnancy complications ,Surgery ,Bladder exstrophy ,Bladder augmentation ,Child, Preschool ,Female ,business ,human activities ,Follow-Up Studies - Abstract
We assessed the probability of bladder augmentation/diversion and clean intermittent catheterization in classic bladder exstrophy in a multi-institutional cohort.We included children born from 1980 to 2016 with bladder exstrophy and treated across 5 centers (exclusion criteria less than 1 year followup after birth, isolated epispadias, bladder exstrophy variants etc). Outcomes were probability of bladder augmentation/diversion after bladder closure and proportion of patients performing clean intermittent catheterization at last followup. Survival analysis was used.Of 216 patients 63.4% were male (median followup 14.4 years). Overall 4 patients (1.9%) underwent primary diversion and 212 underwent primary closure (72.6% in first week of life). After primary closure 50.9% underwent augmentation, 4.7% diversion and 44.8% neither. By age 18 years 88.5% underwent a bladder neck procedure (synchronous augmentation 27.3%). On survival analysis the probability of bladder augmentation/diversion was 14.9% by age 5 years, 50.7% by 10 years and 70.1% by 18 years. Probability of bladder augmentation/diversion varied significantly between centers (p=0.01). Probability of bladder augmentation/diversion was 60.7% 10 years after bladder neck procedure. At last followup of the entire cohort 67.4% performed clean intermittent catheterization. Among 95 patients with intact native bladders 30.5% performed clean intermittent catheterization (channel 72.4%). Among 76 adults without a diversion 85.5% performed clean intermittent catheterization (augmented bladder 100.0% clean intermittent catheterization, native bladder 31.3%). Fifteen patients underwent diversion (continent 8, ureterosigmoidostomy 5, incontinent 2).On long-term followup probability of bladder augmentation/diversion increased with age, with 1 in 2 patients by age 10 years and the majority in adulthood. Probability of bladder augmentation/diversion differed among institutions. Almost a third of patients, including adults, with a closed native bladder performed clean intermittent catheterization. Considering all adults only 14% did not perform clean intermittent catheterization.
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- 2019
354. Adherence with bladder irrigation following augmentation
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M. Francesca Monn, Amr K. Salama, Matthieu Peycelon, Hillary Risk, R. Misseri, Mark P. Cain, and Konrad M. Szymanski
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Adult ,Male ,medicine.medical_specialty ,Urology ,Urinary Bladder ,030232 urology & nephrology ,Therapeutic irrigation ,Bladder Irrigation ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,030225 pediatrics ,Internal medicine ,medicine ,Humans ,Intermittent Urethral Catheterization ,Therapeutic Irrigation ,Spinal Dysraphism ,Univariate analysis ,business.industry ,Urinary Reservoirs, Continent ,medicine.disease ,Regimen ,Neck of urinary bladder ,Cross-Sectional Studies ,Bladder augmentation ,Pediatrics, Perinatology and Child Health ,Patient Compliance ,Urologic Surgical Procedures ,Female ,Bladder stones ,business ,Bladder stone - Abstract
Summary Background Patients with bladder augmentation (BA) are routinely counseled to irrigate their bladders daily. However, reports of adherence with this regimen are lacking. Objective To evaluate adherence to a bladder irrigation protocol and identify risk factors associated with adherence among adults with spina bifida (SB) and BA. Study design Adults with SB after BA followed in a multidisciplinary clinic were identified (2017–2019). All patients or caregivers were taught the importance of and the technique for the bladder irrigation protocol prior to and after BA. Patient demographics (age, gender, ambulatory status, and presence of a caregiver in clinics) and surgical details (type of BA, age at surgery, length of follow-up, presence of a catheterizable channel, position of stoma, bladder neck surgery, presence of Malone antegrade colonic enema or ventriculo-peritoneal shunt, and number of stone surgeries) were obtained from the medical record. Patients reported other variables in a standardized clinic questionnaire. Answers were confirmed by health care providers. The variables included who performs clean intermittent catheterization (CIC), size of catheter, frequency of CIC, use of overnight catheterization, difficulties with CIC, number of UTIs, and continence per urethra and per catheterizable channel. Adherence to bladder irrigation was also assessed in the questionnaire. ‛Strict adherence’ was defined as bladder irrigation performed ≥6 times/week with ≥120 mL of saline. For statistical analysis, a more lenient definition of ‛higher adherence’ was used: bladder irrigation ≥2 times/week with at least 60 mL. ‛Lower adherence’ was defined as ≤1 time/week or with less than 60 mL. Factors associated with ‛higher adherence’ were assessed with non-parametric tests (Bonferroni-corrected p-value: 0.002). Results Adherence was assessed in 87 eligible patients (60.9% females; mean age of 28.8 ± 8.2 years). No patient (0.0%) reported ‛strict adherence’, and 62 and 25 patients (71.3% and 28.7%) reported ‛higher’ and ‛lower’ adherence’ to bladder irrigation, respectively. Nine patients (10.3%) in the ‛lower adherence’ group did not irrigate at all. No variables were statistically significant on univariate analysis, including previous bladder stone surgery or having a channel (p ≥ 0.01). On exploratory analysis, higher adherence was only associated with self-catheterizations versus those performed by caregivers (76.7% vs 33.3%, p = 0.01). Conclusions Adherence to a bladder irrigation protocol in adults with SB and BA is poor. A history of bladder stones requiring surgery and the presence of a catheterizable channel do not appear to affect adherence. It remains unclear why some patients are more likely than others to irrigate their bladders. Future work will focus on methods to improve adherence. Summary Table . Adherence prevalence. N = 87 Strict adherence (≥6/wk. + ≥120 mL) 0 (0.0%) Some adherence (≥2–5/wk. and ≥60 mL) 62 (71.3%) Poor adherence (≤1/wk. or ≤60 mL) 16 (18.4%) No adherence (no irrigation at all) 9 (10.3%) N = 87 Higher adherence (2 or more times/wk. with 60 mL or more each time) 62 (71.3%) Lower adherence (1 time/wk. or less with 60 mL or less each time) 25 (28.7%) mL, milliliter; wk., week.
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- 2019
355. Dynamic programming and automated segmentation of optical coherence tomography images of the neonatal subglottis: enabling efficient diagnostics to manage subglottic stenosis
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Kozlowski, Konrad M, Sharma, Giriraj K, Chen, Jason J, Qi, Li, Osann, Kathryn, Jing, Joseph C, Ahuja, Gurpreet S, Heidari, Andrew E, Chung, Phil-Sang, Kim, Sehwan, Chen, Zhongping, and Wong, Brian J-F
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diagnostic imaging ,Biomedical Engineering ,Bioengineering ,Optical Physics ,Low Birth Weight and Health of the Newborn ,Computer-Assisted ,Clinical Research ,Preterm ,Opthalmology and Optometry ,Infant Mortality ,Humans ,Image Interpretation ,Tomography ,texture analysis ,Pediatric ,screening and diagnosis ,optical coherence tomography ,Infant ,Laryngostenosis ,Optics ,Perinatal Period - Conditions Originating in Perinatal Period ,Newborn ,4.1 Discovery and preclinical testing of markers and technologies ,Detection ,Optical Coherence ,subglottic stenosis ,Biomedical Imaging ,intubation injury ,neonate ,Larynx ,Algorithms ,4.2 Evaluation of markers and technologies - Abstract
Subglottic stenosis (SGS) is a challenging disease to diagnose in neonates. Long-range optical coherence tomography (OCT) is an optical imaging modality that has been described to image the subglottis in intubated neonates. A major challenge associated with OCT imaging is the lack of an automated method for image analysis and micrometry of large volumes of data that are acquired with each airway scan (1 to 2Gb). We developed a tissue segmentation algorithm that identifies, measures, and conducts image analysis on tissue layers within the mucosa and submucosa and compared these automated tissue measurements with manual tracings. We noted small but statistically significant differences in thickness measurements of the mucosa and submucosa layers in the larynx (p
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- 2019
356. Estimating and tracking renal function in children and adults with spina bifida
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Amr K. Salama, David Hains, Konrad M. Szymanski, Arthur J. Szymanski, Mark P. Cain, and Rosalia Misseri
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Adult ,Pediatrics ,medicine.medical_specialty ,Adolescent ,Spinal dysraphism ,Urology ,Population ,030232 urology & nephrology ,Renal function ,Muscle mass ,03 medical and health sciences ,chemistry.chemical_compound ,Young Adult ,0302 clinical medicine ,030225 pediatrics ,medicine ,Humans ,Renal Insufficiency, Chronic ,education ,Child ,Spinal Dysraphism ,Retrospective Studies ,Creatinine ,education.field_of_study ,biology ,Spina bifida ,business.industry ,Middle Aged ,medicine.disease ,Cross-Sectional Studies ,chemistry ,Cystatin C ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,biology.protein ,business ,Kidney disease ,Glomerular Filtration Rate - Abstract
Summary Purpose Estimated glomerular filtration rate (eGFR) in the general population is stable in children after 2 years of age until adulthood. In the first three decades after age 18, eGFR decreases by 0.3–0.8 ml/min/1.73 m2/year. Little data exists regarding eGFR changes in the spina bifida (SB) population given variability in muscle mass. In the absence of a validated SB-specific eGFR formula, the performance of different eGFR formulas may vary. We performed a cross-sectional study (1) to determine trends in eGFR with increasing age in children and adults with SB and (2) to compare eGFRs calculated using different formulas. Methods We retrospectively reviewed records of patients 2–50 years old with SB followed at our institution (2014–2019). We determined eGFR using four pediatric formulas (2–17 years: CKiDSCr, CKiDCys, CKiDSCr-Cys, ZappitelliSCr-Cys) and four adult formulas (18 + years: MDRDSCr, CKD-EPISCr, CKD-EPICys, CKD-EPISCr-Cys). One eGFR per patient was included (most recent eGFR for those with serial measurements). Patients were categorized as chronic kidney disease (CKD) stage 2 (eGFR 60-89) and Stage 3+ ( Results Among 209 children with SB (median age 10.3 years), depending on the formula used, eGFR decreased by −0.7 to −1.8 ml/min/1.73 m2/year (CKiDCys, CKiDScr, p ≤ 0.001), remained stable (CKiDSCr-Cys, p = 0.41), or increased by +2.7/year (ZappitelliSCr-Cys, p Among 164 adults (median age 26.3), eGFR decreased for each formula (range: −1.3 to −2.2/year, p ≤ 0.01) (Figure). The proportion of adults with CKD 2 or higher varied between formulas (9.2–30.5%, p Comment We cannot reliably determine whether eGFR changed during childhood. Among adults, eGFR decreased with age for every formula evaluated at greater than twice the general population rate. Without a validated SB-specific eGFR formula, we are left with formulas providing different results. Conclusions Estimated GFR among adults with SB appears to deteriorate at a higher rate than in the general population. Due to lack of precision of accepted eGFR formulas in the SB population, this may be a real phenomenon, an artifact of inaccurate eGFR formulas, or both. A validated SB-specific eGFR formula is needed. Download : Download high-res image (188KB) Download : Download full-size image Summary Figure . Estimated glomerular filtration rate among 209 children and 164 adults with spina bifida calculated using different published formulas. Formulas for children included: CKiDSCr (blue), CKiDCys (green), CKiDCSCr-ys (black), ZappitelliSCr-Cys (red), adults: MDRDSCr (black), CKD-EPISCr (red), CKD-EPICys (green), CKD-EPISCr-Cys (blue). Curves were drawn using locally estimated scatterplot smoothing (LOESS function).
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- 2019
357. Administration of host‐derived probiotics does not affect utilization of soybean meal enriched diets in juvenile turbot ( Scophthalmus maximus )
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Konrad M. Wanka, Sven Wuertz, Carsten Schulz, and Werner Kloas
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Turbot ,Aquaculture ,Host (biology) ,business.industry ,Soybean meal ,Juvenile ,Saponin degradation ,Food science ,Aquatic Science ,Biology ,business ,biology.organism_classification ,Scophthalmus - Published
- 2019
358. Validation and Preliminary Results of the Parental Assessment of Children's External Genitalia Scale for Females (PACE-F) for Girls With Congenital Adrenal Hyperplasia
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Heather Frady, Richard C. Rink, Martin Kaefer, Patrick O. Monahan, Mark P. Cain, Konrad M. Szymanski, and Benjamin Whittam
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Parents ,Pediatrics ,medicine.medical_specialty ,Cross-sectional study ,Urology ,Population ,030232 urology & nephrology ,Reference range ,03 medical and health sciences ,0302 clinical medicine ,Cronbach's alpha ,medicine ,Humans ,Congenital adrenal hyperplasia ,Sex organ ,Clinical significance ,education ,Child ,education.field_of_study ,Adrenal Hyperplasia, Congenital ,business.industry ,Infant ,Genitalia, Female ,medicine.disease ,Confidence interval ,Cross-Sectional Studies ,030220 oncology & carcinogenesis ,Child, Preschool ,Female ,Self Report ,business - Abstract
To validate a parental assessment of children's external genitalia scale for females (PACE-F) for girls with congenital adrenal hyperplasia (CAH) by adapting the validated adult female genital self-image scale.PACE-F was administered to parents of girls (Tanner 1, 2 months-12 years) with and without CAH. Final questions were determined by clinical relevance and psychometric properties (scores: 0-100). A reference range was established using 95% confidence interval among controls. Age-matched controls were compared to girls with CAH (1)4 years old before and after female genital reconstruction surgery (FGRS), and (2) 4-12-year olds after FGRS. Nonparametric statistics were used.Participants included 56 parents of 41 girls with CAH (median 3.9 years old, 97.6% FGRS) and 139 parents of 130 girls without CAH. Face and content validity was established by families, experts, and factor analysis. Internal consistency was high (Cronbach's alpha: 0.83). Population reference score range was 66.7-100. Ten consecutive girls had pre- and post-FGRS PACE-F scores. All scores improved at 4 months after surgery and all preoperative scores were below reference range and lower than controls (P = .0001). All postoperative scores were within reference range, no different from controls (P = .18). Scores for girls with CAH after FGRS aged 4-12 years were no different from controls (100.0 vs 88.9, P = .77) and 90.0% were in reference range, as expected (P = .99).We present a validated instrument for parental assessment of genital appearance in girls with CAH. We demonstrate improved parent-reported appearance after FGRS, with scores similar to age-matched controls.
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- 2019
359. Treatment and long-term outcome in primary distal renal tubular acidosis
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Lopez-Garcia SC, Emma F, Walsh SB, Fila M, Hooman N, Zaniew M, Bertholet-Thomas A, Colussi G, Burgmaier K, Levtchenko E, Sharma J, Singhal J, Soliman NA, Ariceta G, Basu B, Murer L, Tasic V, Tsygin A, Decramer S, Gil-Peña H, Koster-Kamphuis L, La Scola C, Gellermann J, Konrad M, Lilien M, Francisco T, Tramma D, Trnka P, Yüksel S, Caruso MR, Chromek M, Ekinci Z, Gambaro G, Kari JA, König J, Taroni F, Thumfart J, Trepiccione F, Winding L, Wühl E, Ağbaş A, Belkevich A, Vargas-Poussou R, and Blanchard A
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Acidosis, Renal Tubular/complications/genetics/*therapy ,Adolescent ,Adult ,Aged ,Bicarbonates/blood ,Calcium/urine ,Child ,Child, Preschool ,Cohort Studies ,DNA Mutational Analysis ,Deafness/complications/genetics/therapy ,Female ,Genetic Association Studies ,Glomerular Filtration Rate ,Hearing Loss, Sensorineural/complications/genetics/*therapy ,Humans ,Infant ,Infant, Newborn ,Male ,Middle Aged ,Mutation ,Nephrocalcinosis/complications/genetics/therapy ,Rare Diseases/complications ,Vacuolar P - Abstract
BACKGROUND: Primary distal renal tubular acidosis (dRTA) is a rare disorder, and we aimed to gather data on treatment and long-term outcome. METHODS: We contacted paediatric and adult nephrologists through European professional organizations. Responding clinicians entered demographic, biochemical, genetic and clinical data in an online form. RESULTS: Adequate data were collected on 340 patients (29 countries, female 52%). Mutation testing had been performed on 206 patients (61%); pathogenic mutations were identified in 170 patients (83%). The median (range) presentation age was 0.5 (0-54) years and age at last follow-up was 11.0 (0-70.0) years. Adult height was slightly below average with a mean (SD score) of -0.57 (±1.16). There was an increased prevalence of chronic kidney disease (CKD) Stage ≥2 in children (35%) and adults (82%). Nephrocalcinosis was reported in 88%. Nephrolithiasis was more common with SLC4A1 mutations (42% versus 21%). Thirty-six percent had hearing loss, particularly in ATP6V1B1 (88%). The median (interquartile range) prescribed dose of alkali (mEq/kg/day) was 1.9 (1.2-3.3). Adequate metabolic control (normal plasma bicarbonate and normocalciuria) was achieved in 158 patients (51%), more commonly in countries with higher gross domestic product (67% versus 23%), and was associated with higher height and estimated glomerular filtration rate. CONCLUSION: Long-term follow-up from this large dRTA cohort shows an overall favourable outcome with normal adult height for most and no patient with CKD Stage 5. However, 82% of adult patients have CKD Stages 2-4. Importance of adequate metabolic control was highlighted by better growth and renal function but was achieved in only half of patients.
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- 2019
360. Waveform Feature Implementation for FRIB LLRF Controllers
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Zhao, S., Bernal-Ruiz, E., Konrad, M., Li, Z., Maniar, H., and Morris, D.
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Accelerator Physics (physics.acc-ph) ,Physics - Instrumentation and Detectors ,FOS: Physical sciences ,Physics - Accelerator Physics ,Instrumentation and Detectors (physics.ins-det) - Abstract
Waveform feature is one of the requirements for the FRIB LLRF controllers. It is desired that the LLRF con-trollers store the internal data (e.g. the amplitude and phase information of forward/reverse/cavity signals) for at least one second of sampled data at the RF feedback control loop rate (around 1.25 MHz). One use case is to freeze the data buffer when an interlock event happens and read out the fast data to diagnose the problem. An-other use case is to monitor a set of signals at a decimated rate (user settable) while the data buffer is still running, like using an oscilloscope. The detailed implementation will be discussed in the paper, including writing data into the DDR memory through the native interface, reading out the data through the bus interface, etc., Comment: Poster presented at LLRF Workshop 2019 (LLRF2019, 1909.06754)
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- 2019
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361. Utbedring av falltap i eldre kraftverkstunneler
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Brandtsegg, Konrad M., Langedal, Kristin H., and Mortensen, Robert S.
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Utbyggingen av vannkraftverk fikk en solid fremdrift etter andre verdenskrig. Spesielt i 60-årene startet flere nye kraftverker opp og flere av de er bygd i fjell. Teknikkene for driving av tunneler har endret seg de siste 70 årene. Høyere presisjon, mer effektiv drift og bedre sprengstoffer er noen av stikkordene for forskjeller ved tunneldriving nå mot før. Bruken av bly i sprengstoff er kanskje en av de viktigste forskjellene man bør merke seg. Eldre vannkrafttunneler ble ofte bygd for å opprette enn vannhastighet på 2-3m/s noe som ikke er optimalt etter dagens standard på 1 m/s. Det ligger store potensialer i å forbedre eksisterende tverrsnitt eller å anlegge en ny parallell tunnel ved denne type kraftverker. Tunnsjødal kraftverk som startet opp i 1963 faller under denne beskrivelsen. Vannhastigheten i tilløpstunnelen er opp mot 2 m/s, dette medfører ekstra store friksjonstap i tunneltverrsnittet. De eksisterende tunnelene er underdimensjonert med 1,9 ganger middelvannføringen, normalt for nye tunneler er 0,8-0,9 ganger middelvannføring. For en råsprengt tunnel med ujevn overflate opererer man med Manningstall rundt 30, og råsprengt normal for 35. Manningstallet ved Tunnsjødal er målt til 21 i tilløpstunnel og 17 i avløpstunnel. Dette ligger langt under akseptabelt nivå. Det lave Manningstallet er et resultat av underdimensjonert tverrsnitt og friksjonstap som følge av ruheten i tunneltverrsnittet og singulærtap fra store rasmasser og løsrevet dekke som blokkerer uniformiteten til vannstrømmen. Alternativer for reduksjon av dette friksjonstapet kan være lønnsomt på sikt. Hver cm av falltap i et kraftverk er et direkte tap av potensiell inntekt. Dette må igjen veies opp mot kostnadene en eventuell utbedring vil påløpe seg. I denne oppgaven er det gått nærmere inn på ny tunnel, strossing og rensk. Strossing av eksisterende tunnel til dobbel størrelse gir, ved Manningstall på 35, et falltap på 2,48 m. Det må påberegnes nedetid og tapt produksjon eller en fordeling av arbeidet over flere år for å unngå produksjonstap. Ved å danne en parallelltunnel vil det totale falltapet utgjøre 9,27 m for tunnelen. Dette er noe høyere enn ved utstrossing da vannmengden må fordeles over to tverrsnitt. Fordeler med parallelltunnel er kort nedetid av anlegg, redundans ved vedlikehold, reparasjoner og annet uforutsett. Falltapet kan reduseres med enda noen meter dersom rensk av eksisterende tunnel får høyere ruhet enn benyttet i beregningen. The construction of hydropower plants got a solid boost after WW2. In the 1960’s the building of new powerplants started and several of them where built inside of mountains. The techniques for tunneling have changed over the last 70 years. Better precision, higher efficiency and better explosives is some of the keywords when it comes to the differences in tunneling then and now. The use of lead in explosives is one of the most important differences one should note. Older hydropower plant tunnels were often built to maintain the water velocity at 2-3 m/s, which is suboptimal after todays standard of 1 m/s. There is a great potential in improving existing cross section or building a new parallel tunnel at these powerplants. Tunnsjoedal powerplant, which were put online in 1963, falls under this description. The velocity in the headrace tunnel is up to 2 m/s, this causes a large head loss when the water flows through the tunnel. The existing tunnels is under dimensioned with a target of 1,9 times the median water level, normal for new tunnels is 0,8-0,9 times the median water level. For a rough blasted tunnel with an uneven surface it is expected get a manning’s number of approximately 30, a rough blasted tunnel with a more even surface gives a manning’s number of approximately 35. The manning’s number in Tunnsjoedal is measured to 21 in the headrace tunnel and 17 in the tailrace tunnel. This is far from an acceptable number. The low manning’s number is a result of under dimensioned cross section and friction influences in the form of uneven surfaces and singular losses caused by large masses of rocks. In addition, there is also large pieces of old concrete and asphalt slabs that’s been ripped up from the flooring, laying around in the tunnel. Alternatives for reduction of head loss may prove profitable in the long run. Every inch of head loss in a powerplant is a direct loss of potential profits. This must be compared to the expenses of a possible improvement. In this paper the possibilities of a new parallel tunnel, expanding the existing tunnel and improving the existing tunnel is explored. Back ripping of the existing headrace tunnel up to double its original size results in a total head loss of 2,48 m including an increase of the manning’s number up to 35. Back ripping does involve downtime time and loss of production, unless the construction time is distributed over several years. By constructing a parallel headrace tunnel the total head loss will be 9,27 m. The manning’s number is set at 35 for the new and 30 for the old tunnel. The total head loss is higher than with back ripping because the water flows through two separate tunnels. Advantages such as reducing downtime for the powerplant during construction and being able to production during maintenance and revisions in one of the tunnels should be considered. Some additional meters of head loss can be cut if the scaling manages to increase the manning’s number up to 35 or higher.
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- 2019
362. Die Rolle der Internen Revision in einem BCP-Projekt
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Reimann, Konrad M., primary
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- 2003
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363. Renal Replacement Therapy and Intermittent Catheterization Risk in Posterior Urethral Valves
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Candace F. Granberg, Daryl J. McLeod, Yuri V. Sebastião, Patricio C. Gargollo, Edward M. Gong, Brian A. VanderBrink, Molly Fuchs, Konrad M. Szymanski, Benjamin Whittam, and Pramod P. Reddy
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Posterior urethral valve ,Male ,Pediatrics ,medicine.medical_specialty ,medicine.medical_treatment ,Anticholinergic agents ,Disease ,urologic and male genital diseases ,Cohort Studies ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Urethra ,Risk Factors ,030225 pediatrics ,medicine ,Humans ,Renal replacement therapy ,Intermittent Urethral Catheterization ,Child ,Survival analysis ,Retrospective Studies ,Creatinine ,business.industry ,Retrospective cohort study ,medicine.disease ,Renal Replacement Therapy ,chemistry ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Female ,business ,Cohort study - Abstract
OBJECTIVES: Posterior urethral valves predispose children to renal replacement therapy (RRT) and bladder dysfunction. Researchers of single-institutional series were unable to refine risk stratification because of rarity of the disease. We aimed to identify clinical variables associated with the risk of RRT and clean intermittent catheterization (CIC) in a large multicenter cohort study. METHODS: Children with posterior urethral valves born between 1995 and 2005 who were treated before 90 days of life at 5 children’s hospitals were retrospectively reviewed. Outcomes included RRT and recommendation for CIC. Predictors and outcomes were assessed by using survival analysis. RESULTS: A total of 274 patients were managed for a median of 6.3 years, and 42 progressed to RRT. On survival analysis, 16% progressed to RRT by 10 years of age. RRT varied by the serum nadir creatinine level in the first year of life (SNC1) (log-rank P < .001). After stratifying by the SNC1, the estimated risk of progressing to RRT by 10 years of age was 0%, 2%, 27%, and 100% for an SNC1 of CONCLUSIONS: Risk of RRT and CIC recommendation increased with age. The SNC1 strongly predicted need for RRT. These results allow for both improved family counseling and the potential for more appropriate screening and intervention strategies for those identified in higher-risk groups.
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- 2018
364. Radiographic abnormalities, bladder interventions, and bladder surgery in the first decade of life in children with spina bifida
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Adam J, Rensing, Konrad M, Szymanski, Rosalia, Misseri, Joshua D, Roth, Shelly, King, Katherine, Chan, Benjamin M, Whittam, Martin, Kaefer, Richard C, Rink, and Mark P, Cain
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Male ,Vesico-Ureteral Reflux ,Urinary Bladder ,Infant, Newborn ,Infant ,Hydronephrosis ,Cholinergic Antagonists ,Child, Preschool ,Fluoroscopy ,Urogenital Abnormalities ,Humans ,Female ,Intermittent Urethral Catheterization ,Renal Insufficiency, Chronic ,Child ,Spinal Dysraphism ,Follow-Up Studies ,Retrospective Studies ,Ultrasonography - Abstract
Spina bifida (SB) patients are at increased risk for hydronephrosis, bladder storage and emptying problems, and renal failure that may require multiple bladder surgeries.We retrospectively reviewed patients born with SB 2005-2009, presenting to our institution within 1 year of birth. Outcomes at 8-11 years old included final renal/bladder ultrasound (RBUS) results, clean intermittent catheterization (CIC) use, anticholinergic use, surgical interventions, and final renal function. We excluded those without follow-up past age 8 and/or no RBUS or fluoroscopic urodynamic images (FUI) within the first year of life. Imaging was independently reviewed by four pediatric urologists blinded to radiologists' interpretation and initial findings compared with final outcomes.Of 98 children, 62 met inclusion criteria (48% male, 76% shunted). Median age at last follow-up was 9.6 years. Upon initial imaging, 74% had hydronephrosis (≥ SFU grade 1), decreasing to 5% at 10 years (p 0.0001). Initially, 9% had ≥ SFU grade 3 hydronephrosis, decreasing to 2% (p = 0.13). CIC and anticholinergic use increased from 61% and 37% to 87% and 86%, respectively (p = 0.001 and p 0.0001, respectively). With follow-up, 55% had surgical intervention and 23% had an augmentation. Of children with a serum creatinine/cystatin-C at 8-11 years old, one had confirmed chronic kidney disease (stage 2).Despite initial high incidence of hydronephrosis, this was low grade and resolved in the first decade of life. Additionally, the 8-11-year incidence of kidney disease and upper tract changes was low due to aggressive medical management.
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- 2018
365. Nephronophthise
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Konrad, M., primary
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- 2002
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366. Position of the “Internal Audit Department” in a BCP Project
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Reimann, Konrad M., primary
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- 2002
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367. Molekulargenetische Grundlagen
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Konrad, M., primary
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- 2002
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368. Hereditäre Tubulopathien
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Schärer, K., primary, Konrad, M., additional, Rascher, W., additional, Reusz, G., additional, and Mehls, O., additional
- Published
- 2002
- Full Text
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369. Hereditary Hypokalemic Salt-Losing Tubulopathies: Bartter-Like Syndromes
- Author
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Peters, M., primary, Jeck, N., additional, Seyberth, H.W., additional, and Konrad, M., additional
- Published
- 2001
- Full Text
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370. Hereditary hypokalemic salt-losing tubulopathies
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Jeck, N., primary, Konrad, M., additional, and Seyberth, H.W., additional
- Published
- 2000
- Full Text
- View/download PDF
371. Aging and public institutions: from campuses to prisons, our institutions will need extreme makeovers to serve the public's needs in an aging society
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Kressley, Konrad M.
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Business, general ,Sociology and social work ,Demographic aspects ,Methods - Abstract
Forecasts about the future typically focus on trends in technology, while ignoring demographic factors such as aging populations. This could be a tragic mistake for institutions such as the military, [...]
- Published
- 2005
372. The influence of heteroatom doping on local properties of phosphorene monolayer.
- Author
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Durajski, Artur P., Gruszka, Konrad M., and Niegodajew, Paweł
- Subjects
- *
PHOSPHORENE , *DOPING agents (Chemistry) , *LITHIUM-ion batteries , *MAGNESIUM ions , *ELECTROCHEMISTRY - Abstract
New energy storage technologies that can serve as a reliable alternative to lithium-ion batteries are in the spotlight. Particular attention has been recently devoted to magnesium-ion systems due to the considerable abundance of this element and also due to its promising electro-chemical performance. Our results show that monolayer black phosphorene doped by B, Sc, Co, and Cu atoms possesses good structural stability with the minimal cohesive energy of - 5.563 eV/atom, the adsorption energy per Mg atom ranging from - 1.229 to - 1.357 eV, and the charge transfer from double-side adsorbed single Mg-ions to the B-substituted phosphorene increased by ∼ 0.21 e - in comparison with pristine phosphorene. The present work demonstrates a potential path for future improvements of phosphorus-based anode materials for Mg-ion rechargeable batteries which were evaluated using first-principles density-functional theory calculations. [ABSTRACT FROM AUTHOR]
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- 2021
- Full Text
- View/download PDF
373. Influence of transplantation regimen on prognostic significance of high-level minimal residual disease before allogeneic stem cell transplantation in children with ALL
- Author
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Schneider, M, Hettinger, K, Matthes-Martin, S, Konrad, M, Peters, C, Gadner, H, and Panzer-Grümayer, ER
- Published
- 2001
- Full Text
- View/download PDF
374. Psychiatrische Familienpflege mit gerontopsychiatrischen Langzeitpatienten
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Schmidt-Michel, P.-O., Konrad, M., Jontza, T., Kössinger, I., Möller, Hans-Jürgen, editor, and Rohde, Anke, editor
- Published
- 1993
- Full Text
- View/download PDF
375. Treadmill Training With Partial Body Weight Support and an Electromechanical Gait Trainer for Restoration of Gait in Subacute Stroke Patients: A Randomized Crossover Study
- Author
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Werner, C., von Frankenberg, S., Treig, T., Konrad, M., and Hesse, S.
- Published
- 2002
376. Quantity, Not Frequency, Predicts Bother with Urinary Incontinence and its Impact on Quality of Life in Adults with Spina Bifida
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Richard C. Rink, Konrad M. Szymanski, Mark P. Cain, Rosalia Misseri, Martin Kaefer, and Benjamin Whittam
- Subjects
Adult ,Male ,congenital, hereditary, and neonatal diseases and abnormalities ,medicine.medical_specialty ,Time Factors ,Spinal dysraphism ,Cross-sectional study ,Urology ,030232 urology & nephrology ,Urinary incontinence ,03 medical and health sciences ,0302 clinical medicine ,Quality of life ,medicine ,Humans ,Spinal Dysraphism ,Gynecology ,Health related quality of life ,business.industry ,Spina bifida ,Health related ,Mean age ,medicine.disease ,Cross-Sectional Studies ,Urinary Incontinence ,Quality of Life ,Physical therapy ,Female ,medicine.symptom ,business ,030217 neurology & neurosurgery - Abstract
The effects of urinary incontinence on health related quality of life in adults with spina bifida is poorly understood. We determined which quantification method best captures bother with urinary incontinence. We also quantified the impact of urinary incontinence on health related quality of life.We surveyed an international sample of adults with spina bifida online from January 2013 through September 2014. We evaluated dry intervals (4 hours or greater considered social continence), quantity of urinary incontinence (a lot, medium, little, none) and number of undergarments worn daily (pads, pull-ups or disposable underwear). A 5-point Likert bother scale was used. We applied validated instruments, including QUALAS-A (Quality of Life Assessment in Spina Bifida for Adults) and the generic WHOQOL-BREF (WHO Quality of Life). We analyzed data using linear regression with a range of 0 to 100 for all outcomes.Mean age of the 461 participants was 32 years and 31.0% were male. Overall 26.5% and 51.8% of participants were dry for less than 4 hours and 4 hours or greater, respectively, while 21.7% were always dry. On multivariate analysis worse bother was predominantly determined by the quantity of urinary incontinence (a lot 32.9 and medium 16.2 vs little, p0.0001) rather than dry intervals less than 4 hours (7.21, p = 0.08) or number of undergarments (-2.2 to 4.2, p ≥0.43). Bladder and bowel health related quality of life was lower with higher quantities of urinary incontinence (a lot -31.2, medium -23.0 and little -17.2 vs none, p0.0001) but not for dry intervals less than 4 hours (-4.1, p = 0.14). Use of undergarments regardless of number was associated with lower health related quality of life (-10.2 to -15.4, p ≤0.001). Quantity of urinary incontinence was the main predictor of lower WHOQOL-BREF scores.We report that adults with spina bifida and urinary incontinence have lower health related quality of life than those who are dry. Self-reported quantity of urinary incontinence was the best predictor of bother and health related quality of life.
- Published
- 2016
377. Quality of Life Assessment in Spina Bifida for Children (QUALAS-C): Development and Validation of a Novel Health-related Quality of Life Instrument
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Rosalia Misseri, David Y. Yang, Konrad M. Szymanski, Sonia-Maria Raposo, Mark P. Cain, Benjamin Whittam, Shelly King, Richard C. Rink, and Martin Kaefer
- Subjects
Male ,medicine.medical_specialty ,Psychometrics ,Urology ,030232 urology & nephrology ,MEDLINE ,Pilot Projects ,03 medical and health sciences ,0302 clinical medicine ,Cronbach's alpha ,Quality of life ,Sickness Impact Profile ,Surveys and Questionnaires ,030225 pediatrics ,medicine ,Humans ,Clinical significance ,Child ,Spinal Dysraphism ,Health related quality of life ,Spina bifida ,business.industry ,Reproducibility of Results ,medicine.disease ,Quality of Life ,Physical therapy ,Item generation ,business - Abstract
Objective To develop and validate a self-reported health-related QUAlity of Life Assessment in Spina bifida for Children (QUALAS-C). Methods We drafted a 27-question pilot instrument using a patient-centered comprehensive item generation and refinement process. It was administered to a sample of children 8-12 years old with spina bifida (SB) recruited online via social media and in person at an outpatient SB clinic (January 2013-September 2014). Healthy controls were recruited at routine pediatrician visits. Validation and final questions were determined based on clinical relevance, high loadings on factor analysis, and domain psychometrics. Children with SB also completed the validated generic Kidscreen-27 instrument. Results Median age of 150 participants was 9.6 years (60.7% male, 72.7% Caucasian), similar to 46 controls (P ≥ .10). There were 97 online and 53 clinic participants (89.0% and 84.2% of eligible, respectively). Face and content validities of the 2-domain, 10-question QUALAS-C were established by patients, parents, and experts. Internal consistency and test-retest reliability was high for the Esteem & Independence and Bladder & Bowel domains (Cronbach's alpha: 0.72-0.76, ICC: 0.74-0.77). Correlations between QUALAS-C domains were low (r = 0.51), indicating that QUALAS-C can differentiate between two distinct health-related quality of life components. Correlations between QUALAS-C and Kidscreen-27 were also low (r ≤ 0.44). QUALAS-C scores were significantly lower in children with SB than without (P Conclusion QUALAS-C is a short, valid health-related quality of life tool for children with SB. It will be useful in clinical and research settings.
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- 2016
378. Use of retrograde pyelogram to plan for miniature open incision in pediatric pyeloplasty
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Ben Whittam, Jessica T. Casey, Amr K. Salama, Konrad M. Szymanski, Mark P. Cain, and Joshua Roth
- Subjects
medicine.medical_specialty ,Pyeloplasty ,Urology ,medicine.medical_treatment ,030232 urology & nephrology ,Kidney ,Retrograde pyelography ,Iliac crest ,Open pyeloplasty ,03 medical and health sciences ,0302 clinical medicine ,Robotic Surgical Procedures ,030225 pediatrics ,Humans ,Medicine ,Kidney Pelvis ,Child ,Retrospective Studies ,Pelvic kidney ,business.industry ,Urography ,medicine.disease ,Single surgeon ,Surgery ,Abdominal incision ,Treatment Outcome ,medicine.anatomical_structure ,Incision Site ,Pediatrics, Perinatology and Child Health ,Urologic Surgical Procedures ,Laparoscopy ,business ,Ureteral Obstruction - Abstract
As robotic-assisted surgery becomes increasingly utilized for pediatric ureteropelvic junction (UPJ) obstruction, open surgeons have countered by using muscle-splitting, miniature (≤2 cm) incisions. To prepare for this type of incision during pyeloplasty, it is necessary to define the exact location of the UPJ. The use of retrograde pyelogram (RPG) at the time of pyeloplasty helps the surgeon to identify the exact location of UPJ, and thus be able to use a muscle-splitting, miniature incision for open pyeloplasty.We hypothesize that when performing a muscle-splitting, miniature incision open approach; preoperative RPG frequently changes the traditional pyeloplasty flank incision at the tip of the 11th or 12th rib.A retrospective review of open pyeloplasties performed by a single surgeon at our institution from 7/1/2010 to 12/31/2018 was performed to determine rate of use of RPG, open pyeloplasty incision location and to determine what factors are predictive of incisional site.114 of 122 (93.4%) patients with 115 renal units had pyeloplasties with preoperative RPG performed. Of the 8 procedures without RPG, two had a pelvic kidney diagnosed prior to surgery, two had narrow ureteric orifices that were difficult to cannulate, and four had associated reflux. In 31/115 (27%) pyeloplasties the incision was changed from a standard incision position at the 11th or 12th rib to an alternative incision (i.e. extended muscle-transecting incision at the tip of the 11th or 12th rib, or to an alternate incision site including Gibson, McBurney's incision, or low anterior abdominal incision). 84/115 (73.0%) had a miniature (2 cm) incision at the tip of the 11th or 12th rib. Grade IV hydronephrosis was a significant predictor for changing the traditional incision site (p = 0.02). Preoperative nephrostomy tube insertion was also associated with an increased likelihood of having an alternate incision (p = 0.04). Incision site was not significantly affected by age of the patient at surgery, patient sex, size of the affected kidney, T1/2 times of30 min, split function of30%, kidney length differential, or laterality.The consistent use of RPG prior to pyeloplasty helps surgeons to plan for a small muscle-splitting, miniature open incisions. In our experience, 27% of pyeloplasties required alternative incision sites based on the results of pre-operative RPG.
- Published
- 2020
379. Factors impacting transition readiness in young adults with neuropathic bladder
- Author
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Mark P. Cain, Konrad M. Szymanski, Rosalia Misseri, and Joshua D. Roth
- Subjects
Adult ,Male ,Gerontology ,Transition to Adult Care ,Activities of daily living ,Urology ,Population ,030232 urology & nephrology ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,030225 pediatrics ,Health care ,medicine ,Humans ,Generalizability theory ,Urinary Bladder, Neurogenic ,Young adult ,education ,Spinal Dysraphism ,education.field_of_study ,Univariate analysis ,business.industry ,Spina bifida ,Cognition ,medicine.disease ,Cross-Sectional Studies ,Pediatrics, Perinatology and Child Health ,Female ,business - Abstract
Summary Introduction Patients with spina bifida (SB) often have cognitive impairments making the difficult transition process to adult care even more challenging. Objective The objective of this study was to identify what patient factors impact transition readiness in this population. It is hypothesized that young adults with SB with more healthcare exposure were more likely to report readiness to transition. Methods Consecutive patients ≥ 18 years old in the adult SB clinic were evaluated using the validated Transition Readiness Assessment Questionnaire (TRAQ, 8/17-5/18). Five TRAQ domains assess 20 skills necessary to transition. Responses are 1 No, I do not know how"; 2 No, but I want to learn"; 3 No, but I am learning how to do this"; 4 Yes, I have started doing this"; 5 Yes, I always do this when I need to" (considered "fully transitioned"). Demographics, ambulatory status, shunt status, shunt revisions, number of medications, and prior bladder augmentation were assessed. Domain and total TRAQ scores were analyzed using non-parametric statistics and linear regression. Results Ninety-six patients (60.4% females, 70.8% shunted) participated at median age 25.5 years. Overall median TRAQ score was 4.0/5.0, indicating that patients were starting to transition. On univariate analysis, age >25 years was associated with higher TRAQ scores across every domain and overall (P ≤ 0.01). Female gender was also associated with higher TRAQ scores for "Appointment Keeping," "Tracking Health Issues" and overall (P ≤ 0.03). Race, ambulatory status, shunt status, number of shunt revisions, number of medications, and prior bladder augmentation were not associated with TRAQ scores (P ≥ 0.12). After adjusting for gender on bivariate analysis, age >25 years was associated with higher TRAQ scores for "Appointment Keeping," "Tracking Health Issues," "Talking with Providers," and "Managing Daily Activities" domains and overall (P ≤ 0.03), but not the "Managing Medications" domain (P = 0.07). Female gender was not independently associated with higher domain or overall TRAQ scores (P≥0.10). Discussion The transition readiness of young adults with SB compared based on demographic factors and factors increasing healthcare exposure is described. Limitations include the small sample size, potentially limiting generalizability, as well as cross-sectional nature. Conclusion Transitioning adults with SB had TRAQ scores indicating that they were not yet fully transitioned in terms of their healthcare-related behavior. Older age was the only factor associated with transition readiness, which was not impacted by other demographics. Increased attention to transition readiness and consideration of a longer transition process in this population is necessary.
- Published
- 2020
380. HYDROLOGY OF WETLANDS IN CULTURAL LANDSCAPES OF NORTH-EAST GERMANY
- Author
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Konrad, M.
- Subjects
restoration ,cultivation ,грунтовые воды ,восстановление нарушенных экосистем ,groundwater ,food and beverages ,ditch drain ,дренажная траншея ,водно-болотные угодья ,культивация ,гидропроводность ,hydraulic conductivity ,wetlands - Abstract
About 12.7 % of the German Federal State Mecklenburg-Vorpommern is covered by wetlands. They are predominantly drained by systems of open ditches. Only a small proportion about 2.8 % remained near-natural. If the water level of the receiving water is lower than the water level of the wetland, its discharge is realized gravitationally by an outlet construction like a weir or sill, either uncontrolled or regulated. In the opposite case, the water has to be elevated into the receiving water body by a pumping station. The interaction between ditches and groundwater depends significantly on saturated hydraulic conductivity of the soil substrate or aquifer. This key factor is also determining in re-wetting lowlands. In case of high hydraulic conductivity, a ditch impounding is sufficient to re-wet the area by subsurface flow processes. However, soils with a low conductivity require a water logging or even a flooding to be re-wetted. This is often the case in, for example, degraded wetlands and especially during summer conditions with high potential evapotranspiration., Около 12,7% федерального штата Мекленбург-Ворпоммерн, Германия покрыты водно-болотными угодьями. Они преимущественно дренируются системами открытых канав. Только небольшая часть этих территорий (2,8 %) сохранена в естественном состоянии. В основном болота осушены системами открытых траншей, сообщающимися с естественными водными объектами. В случае, когда уровень воды в водоёме-приёмнике ниже уровня воды в траншее, происходит сброс через регулируемый или нерегулируемый водослив. В противном случае, уровень подтопления регулируется при помощи насосов. Взаимодействие между траншеями и подземными водами существенно зависит от гидропроводности почвенного субстрата или водоносного горизонта. Более того гидропроводность является решающим фактором при выборе мероприятий для восстановления природного болотного ландшафта. В случае высокой гидропроводности запруднение траншей достаточно для восстановления заболоченной территории. Если же гидропроводность низкая, как в случае осушенных болот, необходимо заболачивание или даже затопление восстанавливаемой местности, особенно в летний период при высоком потенциальном суммарном испарении.
- Published
- 2018
- Full Text
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381. Transitioning young adults with neurogenic bladder-Are providers asking too much?
- Author
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R. Misseri, E.J. Ferguson, Mark P. Cain, Joshua D. Roth, and Konrad M. Szymanski
- Subjects
Adult ,Male ,medicine.medical_specialty ,Transition to Adult Care ,Physical disability ,Adolescent ,Health Personnel ,Urology ,030232 urology & nephrology ,Risk Assessment ,Likert scale ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Sex Factors ,Reference Values ,030225 pediatrics ,Surveys and Questionnaires ,Adaptation, Psychological ,medicine ,Humans ,Transitional care ,Generalizability theory ,Young adult ,Urinary Bladder, Neurogenic ,Spinal Dysraphism ,business.industry ,Spina bifida ,digestive, oral, and skin physiology ,Small sample ,Cognition ,medicine.disease ,Adaptation, Physiological ,Self Care ,Cross-Sectional Studies ,Treatment Outcome ,Pediatrics, Perinatology and Child Health ,Physical therapy ,Quality of Life ,Female ,business - Abstract
Significant numbers of young adults with chronic health conditions fail to transition.The aim of the study was to evaluate how ready transitioned urologic patients were for that process. Owing to the cognitive impairments frequently seen with spina bifida (SB), it is hypothesized that these individuals will be less prepared to transition their medical care to adult providers compared with their healthy counterparts.Participants included consecutive patients in the transitional SB clinic at the study institution and controls (college students without obvious physical disability or interest in healthcare-related fields aged 18-25 years). Both groups were administered the Transition Readiness Assessment Questionnaire (TRAQ) over a nine-month period. Five TRAQ domains assess 20 skills necessary to transition. Likert scale responses range from 1 "no, I do not know how" to 5 "yes, I always do this when I need to" (which the authors considered appropriate for transitioned patients). Demographics and the number of daily medications taken were collected. Patients and healthy controls were compared using (1) total and domain TRAQ scores, (2) the proportion of non-transitioned skills ("1"), and (3) fully transitioned skills ("5"). Non-parametric statistics were used.Forty-three unique SB patients (30.8% shunted, 46.5% female) and 100 controls were enrolled. Patients with SB were older than controls (21 vs 20 years, p 0.001). There was no gender difference between groups (p = 0.33). Transitioned patients and college students were fully transitioned only in the "Talking with Providers" domain (Figure). College students performed significantly better than patients in the domains of "Appointment Keeping" (p = 0.04) and "Tracking Health Issues" (p = 0.02). Transitioned patients were less likely to be interested in learning how to perform skills in the domains of "Appointment Keeping" and "Tracking Health Issues" (p 0.001 for both domains).The transition readiness of young adults with SB compared to healthy controls and other youths with chronic health conditions is described. The limitations include the small sample size, potentially limiting generalizability, and cross-sectional nature."Transitioned" patients with SB had lower TRAQ scores in some domains compared to healthy college students, who themselves had scores indicating that they were not fully ready for transition. Increased attention to transition readiness in people with SB is necessary, as even healthy young adults struggle with these tasks and are poorly prepared for transition.
- Published
- 2018
382. Evaluation of Turbulence Models for the Design of Continuously Adapted Riblets
- Author
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Konrad M. Hartung, Karsten Oehlert, and Christoph A. Million
- Subjects
Turbulence ,Mechanics ,Geology - Published
- 2018
383. Quasi-free photoproduction of η -mesons off the deuteron
- Author
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Jaegle, I., Krusche, B., Anisovich, A., Bacelar, J., Bantes, B., Bartholomy, O., Bayadilov, D., Beck, R., Beloglazov, Y., Castelijns, R., Crede, V., Dieterle, M., Dutz, H., Elsner, D., Ewald, R., Frommberger, F., Funke, C., Gothe, R., Gregor, R., Gridnev, A., Gutz, E., Hillert, W., Höffgen, S., Hoffmeister, P., Horn, I., Junkersfeld, J., Kalinowsky, H., Kammer, S., Keshelashvili, I., Kleber, V., Klein, Frank, Klein, Friedrich, Klempt, E., Konrad, M., Kotulla, M., Lang, M., Löhner, H., Lopatin, I., Lugert, S., Maghrbi, Y., Menze, D., Mertens, T., Messchendorp, J., Metag, V., Nikonov, V., Nanova, M., Novinski, D., Novotny, R., Oberle, M., Ostrick, M., Pant, L., van Pee, H., Pfeiffer, M., Pheron, F., Roy, A., Sarantsev, A., Schadmand, S., Schmidt, C., Schmieden, H., Schoch, B., Shende, S., Sokhoyan, V., Süle, A., Sumachev, V., Szczepanek, T., Thoma, U., Trnka, D., Varma, R., Walther, D., Wendel, C., Werthmüller, D., and Witthauer, L.
- Subjects
Nuclear Theory ,Nuclear Experiment - Abstract
Precise data for quasi-free photoproduction of η-mesons off the deuteron have been measured at the Bonn ELSA accelerator with the combined Crystal Barrel/TAPS detector for incident photon energies up to 2.5GeV. The η-mesons have been detected in coincidence with recoil protons and neutrons. Possible nuclear effects like Fermi motion and re-scattering can be studied via a comparison of the quasi-free reaction off the bound proton to η-production off the free proton. No significant effects beyond the folding of the free cross-section with the momentum distribution of the bound protons have been found. These Fermi motion effects can be removed by an analysis using the invariant mass of the η-nucleon pairs reconstructed from the final-state four-momenta of the particles. The total cross-section for quasi-free η-photoproduction off the neutron reveals even without correction for Fermi motion a pronounced bump-like structure around 1GeV of incident photon energy, which is not observed for the proton. This structure is even narrower in the invariant-mass spectrum of the η-neutron pairs. Position and width of the peak in the invariant-mass spectrum are W ≈ 1665 MeV and FWHM Γ ≈ 25 MeV. The data are compared to the results of different models
- Published
- 2018
384. Towards Immersed Boundary Methods For Complex Roughness Structures In Scale-Resolving Simulations
- Author
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Florian Herbst, Konrad M. Hartung, and Philipp Gilge
- Subjects
Materials science ,Scale (ratio) ,Boundary (topology) ,Mechanics ,Surface finish - Published
- 2018
385. Numerical Supported Design Of Continuously Adapted Riblets For Viscous Drag Reduction On A NREL Wind Turbine Airfoil
- Author
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Konrad M. Hartung, Karsten Oehlert, and Jan H. Haake
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Reduction (complexity) ,Airfoil ,Materials science ,Drag ,Mechanics ,Turbine - Published
- 2018
386. Incidence of pathologic postobstructive diuresis after resolution of ureteropelvic junction obstruction with a normal contralateral kidney
- Author
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Jeffrey D. Lesier, Richard C. Rink, Rosalia Misseri, Joshua D. Roth, Konrad M. Szymanski, Mark P. Cain, Benjamin Whittam, and Jessica T. Casey
- Subjects
Male ,medicine.medical_specialty ,Pyeloplasty ,Urology ,medicine.medical_treatment ,030232 urology & nephrology ,Diuresis ,Kidney ,03 medical and health sciences ,Lethargy ,0302 clinical medicine ,Postoperative Complications ,Interquartile range ,030225 pediatrics ,medicine ,Humans ,Kidney Pelvis ,Child ,Hydronephrosis ,Nephrostomy, Percutaneous ,Retrospective Studies ,business.industry ,Incidence ,Infant ,medicine.disease ,Urination Disorders ,Hypokalemia ,Percutaneous nephrostomy ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Female ,Stents ,medicine.symptom ,business ,Hyponatremia ,Ureteral Obstruction - Abstract
Summary Introduction Postobstructive diuresis (POD) after unilateral pyeloplasty or percutaneous nephrostomy (PCN) tube insertion for ureteropelvic junction obstruction (UPJO) in patients with a normal contralateral kidney is not well described. Objective The objective of this study was to determine the incidence and characteristics of POD after relief of unilateral UPJO in patients with a normal contralateral kidney. Study design Children who underwent a unilateral pyeloplasty or PCN for UPJO from 2010 to 2017 with a normal contralateral kidney were retrospectively reviewed. Postobstructive diuresis was defined as urine output (UO) of >300% of expected UO. Patients with a solitary kidney or those who underwent bilateral pyeloplasty or bilateral PCN tube placement were excluded. Results Out of 396 children meeting inclusion criteria, seven (1.8%) developed POD (4 after pyeloplasty and 3 after PCN tube placement). Median age at intervention was 1.7 years (range 11 days–18 years); median weight was 11.4 kg (range 3.7–54.2 kg). Postobstructive diuresis was more likely to occur in patients with grade 4 hydronephrosis (3.0%) and larger kidneys and if a PCN tube was placed before pyeloplasty. There was no significant difference in age, gender, kidney laterality, or function between those who developed POD and those who did not. Postobstructive diuresis was managed with additional intravenous fluids and electrolyte monitoring. Median initial postprocedure UO was 5.9 mg/kg/hr (range 3.2–10.0 mg/kg/hr). In five children who underwent PCN in whom UO could be differentiated between kidneys, median initial postprocedure UO was 6.1 mg/kg/hr (range 2.5–9.1 mg/kg/hr) from the affected side and 0.8 mg/kg/hr (range 0.4–0.9 mg/kg/hr) from the unaffected side. The median length of time to resolution of POD was 3 days (range 2–4 days). One patient developed significant acidosis and lethargy that improved with intravenous fluid management. Mild hyponatremia developed in two, hypokalemia in one, hypophosphatemia in one, acidosis in one, and hypoglycemia in 1 patient. Discussion A low but clinically significant risk of POD occurring after relief of unilateral UPJO in children with a normal contralateral kidney is described. Limitations include retrospective analysis and small sample size due to the rarity of the condition. Conclusion Postobstructive diuresis after decompression of UPJO in patients with a normal contralateral kidney is a rare event (1.8%). However, POD does occur, and patients should be carefully monitored after these procedures given the potential for significant dehydration and electrolyte disturbances. Table . Predictors of postobstructive diuresis. Factors affecting postobstructive diuresis No POD (N = 389) POD (N = 7) P-value Grade of hydronephrosis of the affected kidney before intervention, # (%) 3 or lower 166 (42.7%) 0 (0%) 0.04 4 223 (57.3%) 7 (100.0%) Median size differential of the affected compared to the unaffected kidney, cm (IQR) +1.4 (+2.4 to −0.8) +4.4 (+5.6 to −2.5) 0.02 Median size ratio of the affected to the unaffected kidney (IQR) 1.2 (1.1–1.4) 1.8 (1.5–2.1) 0.01 Need for nephrostomy tube before pyeloplasty, # (%) 23 (5.9%) 3 (42.9%) IQR, interquartile range; POD, postobstructive diuresis.
- Published
- 2018
387. PD48-01 URINARY AND FECAL INCONTINENCE DURING SEXUAL ACTIVITY IS COMMON AND BOTHERSOME AMONG ADULTS WITH SPINA BIFIDA
- Author
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Devon J. Hensel, John S. Wiener, Joshua Roth, Konrad M. Szymanski, and Rosalia Misseri
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medicine.medical_specialty ,business.industry ,Obstetrics ,Spina bifida ,Urology ,Urinary system ,Medicine ,Fecal incontinence ,medicine.symptom ,business ,medicine.disease - Published
- 2018
388. MP56-17 SACRAL NERVE STIMULATOR SUCCESS AFTER FILUM SECTION FOR REFRACTORY VOIDING DYSFUNCTION
- Author
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Konrad M. Szymanski, Benjamin Whittam, Adam J. Rensing, Sally Dunn, Shelly King, and Mark P. Cain
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medicine.medical_specialty ,Refractory ,business.industry ,Urology ,Section (typography) ,medicine ,Sacral nerve ,business ,Surgery - Published
- 2018
389. Clinical evaluation of subglottic stenosis in neonates using automatic segmentation of optical coherence tomography via dynamic programming (Conference Presentation)
- Author
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Brian J. F. Wong, Konrad M. Kozlowski, Li Qi, Giriraj K. Sharma, Zhongping Chen, Jason J. Chen, and Joseph C. Jing
- Subjects
Larynx ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Subglottic stenosis ,medicine.disease ,medicine.anatomical_structure ,Optical coherence tomography ,Submucosa ,medicine ,Medical imaging ,Segmentation ,Radiology ,Airway ,Subglottis ,business - Abstract
Subglottic stenosis is a severe and challenging disease to manage in neonates. Previous reports describe the usage of long-range optical coherence tomography (LR-OCT) to image the subglottis through an endotracheal tube and potentially identify subepithelial changes in subglottic mucosa which are correlated with edema or scar tissue. A major challenge associated with OCT imaging is that large volumes of data (1-2 GB) are acquired with each airway scan, with no existing automated method for image analysis and tissue measurement. We have developed an innovative MATLAB based auto-segmentation program which identifies and measures tissue layers within the mucosa. LR-OCT data sets of 21 neonates were analyzed for mucosal thickness of the proximal trachea, subglottis and larynx. The auto-segmentation measurements were compared with measurements from manual tracings by a single operator. We found statistically significant associations between the thickness of the mucosa (p
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- 2018
390. Early readmission and reoperation characteristics of ambulatory hypospadias repair
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Mark P. Cain, Aaron E. Carroll, Konrad M. Szymanski, Joshua D. Roth, William E. Bennett, Benjamin Whittam, and R. Misseri
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Male ,Reoperation ,medicine.medical_specialty ,Time Factors ,Urologic Surgical Procedures, Male ,Adolescent ,Urology ,030232 urology & nephrology ,Logistic regression ,Patient Readmission ,03 medical and health sciences ,0302 clinical medicine ,Postoperative Complications ,030225 pediatrics ,Epidemiology ,Hypospadias repair ,Medicine ,Humans ,Child ,Hypospadias ,business.industry ,General surgery ,Infant ,Emergency department ,medicine.disease ,Ambulatory Surgical Procedures ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Ambulatory ,Cohort ,Mixed effects ,business - Abstract
Hypospadias is a common birth defect. It is present in about 34.2 in 10,000 live births in North America. However, few studies have evaluated the immediate reoperation and readmission rates following elective repair.This study aimed to define the rates of readmission and reoperation following elective hypospadias repair, to improve pre-operative counseling on risks of the procedure.The Pediatric Health Information System (PHIS) was interrogated from 2004 to 2015 for all elective hypospadias repairs (ICD-9-CM code 58.45) performed in the ambulatory surgical setting. The following were then determined: age at initial operation, insurance status, race, presence or absence of readmission or reoperation within 30 days, presence of repeat hypospadias repair (same ICD-9 code), and presence or absence of another urethral operation (ICD-9 CM code 58.XX, excluding 58.45). Mixed effects logistic regression were then performed with dependent variables of 30-day repeat encounter, 30-day emergency department (ED) visit, 30-day readmission, or 30-day reoperation; and independent variables of age, race, ethnicity, and insurance status.The study identified 45,264 hypospadias repairs during 2004-2015 performed in 43 hospitals. Within 30 days of the procedures, 2826 (6.2%) had additional encounters in the ED at the same facilities, and 546 (1.2%) had readmissions. A total of 105 (0.2%) underwent second anesthetic within the first 30 days. With regards to a 30-day repeat encounter, odds of repeat encounter were significantly increased in patients aged5 years, Black and Asian patients, and those with Medicaid. Of the 4882 repeat encounters, 954 (19.5%) had discharge ICD-9 codes related to the penis, or to postoperative complications in general.This study described the epidemiology of clinical events occurring at the same tertiary children's hospital within the first 30 days following more than 45,000 hypospadias repairs. Limitations included a cohort generated from a single set of ICD-9 codes.Elective hypospadias repair had a low rate of readmission (1.2%) and reoperation (0.2%) within the first 30 days. Patients aged5 years, of non-white race, Hispanic ethnicity, and on Medicaid had significantly higher odds of 30-day repeat encounters.
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- 2018
391. Isolation and characterization of native probiotics for fish farming
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Konrad M. Wanka, Thilo Damerau, Benjamin Costas, Angela Krueger, Carsten Schulz, and Sven Wuertz
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Acinetobacter ,Bacteria ,Probiotics ,lcsh:QR1-502 ,Fishes ,Psychrobacter ,Saponin metabolization ,PUFA ,Probiotic supplementation ,Aquaculture ,Diet preparation ,Oral administration ,Tenacibaculum maritimum ,Animal Feed ,lcsh:Microbiology ,Gastrointestinal Tract ,Animals - Abstract
Background Innovations in fish nutrition act as drivers for the sustainable development of the rapidly expanding aquaculture sector. Probiotic dietary supplements are able to improve health and nutrition of livestock, but respective bacteria have mainly been isolated from terrestrial, warm-blooded hosts, limiting an efficient application in fish. Native probiotics adapted to the gastrointestinal tract of the respective fish species will establish within the original host more efficiently. Results Here, 248 autochthonous isolates were cultured from the digestive system of three temperate flatfish species. Upon 16S rRNA gene sequencing of 195 isolates, 89.7% (n = 175) Gram-negatives belonging to the Alpha- (1.0%), Beta- (4.1%) and Gammaproteobacteria (84.6%) were identified. Candidate probiotics were further characterized using in vitro assays addressing 1) inhibition of pathogens, 2) degradation of plant derived anti-nutrient (saponin) and 3) the content of essential fatty acids (FA) and their precursors. Twelve isolates revealed an inhibition towards the common fish pathogen Tenacibaculum maritimum, seven were able to metabolize saponin as sole carbon and energy source and two isolates 012 Psychrobacter sp. and 047 Paracoccus sp. revealed remarkably high contents of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). Furthermore, a rapid and cost-effective method to coat feed pellets revealed high viability of the supplemented probiotics over 54 d of storage at 4°C. Conclusions Here, a strategy for the isolation and characterization of native probiotic candidates is presented that can easily be adapted to other farmed fish species. The simple coating procedure assures viability of probiotics and can thus be applied for the evaluation of probiotic candidates in the future.
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- 2018
392. Canadian Urological Association/Pediatric Urologists of Canada guideline on the investigation and management of antenatally detected hydronephrosis
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Luis H. Braga, Konrad M. Szymanski, and John-Paul Capolicchio
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Abdominal pain ,Pediatrics ,medicine.medical_specialty ,Urinary infection ,business.industry ,Urology ,Urinary system ,030232 urology & nephrology ,Early detection ,Guideline ,CUA Guideline ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,Oncology ,030225 pediatrics ,Failure to thrive ,Antenatal Hydronephrosis ,medicine ,medicine.symptom ,business ,Hydronephrosis - Abstract
Prior to the advent of maternal ultrasonography in the 1980s, children with significant congenital hydronephrosis requiring surgery presented symptomatically with abdominal pain, urinary infection, hypertension, hematuria, or failure to thrive. Antenatal hydronephrosis (AHN) became one of the most commonly detected ultrasound (US) findings, affecting 1–5% of pregnancies.1 The majority of AHN in the third trimester is discovered due to US for maternal indications. The benefits of this early detection of urinary tract dilation include a reduction in the renal damage due to obstruction and infection.2,3 On the other hand, many of these antenatally detected cases spontaneously resolve with observation and consequently can be submitted to unnecessary investigations and continued medical followup.4 The challenge to this day remains to predict which of these prenatally detected infants will require corrective surgery, prior to the development of symptoms or potentially irreversible renal damage, thus permitting a more tailored screening.
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- 2018
393. Mineral dust in central asia: 18-month lidar measurements in tajikistan during the central Asian dust experiment (CADEX)
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Julian?Hofer, Dietrich?Althausen, Sabur F.?Abdullaev, Abduvosit?Makhmudov, Bakhron I.?Nazarov, Georg?Schettler, K.Wadinga?Fomba, Konrad?M?ller, Bernd?Heinold, Holger?Baars, Ronny?Engelmann, Albert?Ansmann, D.?Nicolae, A.?Makoto, A.?Vassilis, D.?Balis, A.?Behrendt, A.?Comeron, F.?Gibert, E.?Landulfo, M. P.?McCormick, C.?Senff, I.?Veselovskii, U.?Wandinger, Nicolae, D., Makoto, A., Vassilis, A., Balis, D., Behrendt, A., Comeron, A., Gibert, F., Landulfo, E., McCormick, M., Senff, C., Veselovskii, I., and Wandinger, U.
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010504 meteorology & atmospheric sciences ,010308 nuclear & particles physics ,Asian Dust ,Raman lidar ,Physics ,QC1-999 ,Climate system ,Central asia ,Mineral dust ,Atmospheric sciences ,01 natural sciences ,Lidar ,0103 physical sciences ,Radiative transfer ,0105 earth and related environmental sciences - Abstract
Tajikistan is often affected by atmospheric mineral dust. The direct and indirect radiative effects of dust play a sensitive role in the climate system in Central Asia. The Central Asian Dust Experiment (CADEX) provides first lidar measurements in Tajikistan. The autonomous multiwavelength polarization Raman lidar PollyXT was operated for 1.5 years (2015/16) in Dushanbe. In spring, lofted layers of long-range transported dust and in summer/ autumn, lower laying dust from local or regional sources with large optical thicknesses occurred.
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- 2018
394. G-quadruplex-binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo
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Simone, R., Balendra, R., Moens, T., Preza, E., Wilson, K., Heslegrave, A., Woodling, N., Niccoli, T., Gilbert-Jaramillo, J., Abdelkarim, S., Clayton, E., Clarke, M., Konrad, M., Nicoll, A., Mitchell, J., Calvo, A., Chio, A., Houlden, H., Polke, J., Ismail, M., Stephens, C., Vo, T., Farahat, A., Wilson, W., Boykin, D., Zetterberg, H., Partridge, L., Wray, S., Parkinson, G., Neidle, S., Patani, R., Fratta, P., and Isaacs, A.
- Abstract
Intronic GGGGCC repeat expansions in C9orf72 are the most common known cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), which are characterised by degeneration of cortical and motor neurons, respectively. Repeat expansions have been proposed to cause disease by both the repeat RNA forming foci that sequester RNA-binding proteins and through toxic dipeptide repeat proteins generated by repeat-associated non-ATG translation. GGGGCC repeat RNA folds into a G-quadruplex secondary structure, and we investigated whether targeting this structure is a potential therapeutic strategy. We performed a screen that identified three structurally related small molecules that specifically stabilise GGGGCC repeat G-quadruplex RNA We investigated their effect in C9orf72 patient iPSC-derived motor and cortical neurons and show that they significantly reduce RNA foci burden and the levels of dipeptide repeat proteins. Furthermore, they also reduce dipeptide repeat proteins and improve survival in vivo, in GGGGCC repeat-expressing Drosophila Therefore, small molecules that target GGGGCC repeat G-quadruplexes can ameliorate the two key pathologies associated with C9orf72 FTD/ALS These data provide proof of principle that targeting GGGGCC repeat G-quadruplexes has therapeutic potential.
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- 2018
395. A Rare Case of Fulvestrant-Associated Jaundice and Hepatotoxicity
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Patrick Kohlitz, Konrad M. Dziamski, and Aditya Kalakonda
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0301 basic medicine ,medicine.medical_specialty ,Antineoplastic Agents, Hormonal ,Jaundice ,Breast Neoplasms ,Adenocarcinoma ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Rare case ,medicine ,Humans ,Pharmacology (medical) ,Aspartate Aminotransferases ,Fulvestrant ,Aged ,Pharmacology ,business.industry ,Alanine Transaminase ,General Medicine ,030104 developmental biology ,030220 oncology & carcinogenesis ,Female ,Chemical and Drug Induced Liver Injury ,medicine.symptom ,business ,medicine.drug - Published
- 2019
396. Dynamic programming and automated segmentation of optical coherence tomography images of the neonatal subglottis: enabling efficient diagnostics to manage subglottic stenosis
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Kozlowski, Konrad M., primary, Sharma, Giriraj K., additional, Chen, Jason J., additional, Qi, Li, additional, Osann, Kathryn, additional, Jing, Joseph C., additional, Ahuja, Gurpreet S., additional, Heidari, Andrew E., additional, Chung, Phil-Sang, additional, Kim, Sehwan, additional, Chen, Zhongping, additional, and Wong, Brian J.-F., additional
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- 2019
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- View/download PDF
397. Duration of sick leave in patients with depression treated by general practitioners and psychiatrists
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Konrad, M., primary, Bohlken, J., additional, and Kostev, K., additional
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- 2019
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- View/download PDF
398. Risk of Reaugmentation after Enterocystoplasty Using a Reconfigured Bowel Segment in Patients with Spina Bifida: A Bi-Institutional Cohort Study
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VanderBrink, Brian A., primary, Szymanski, Konrad M., additional, Alam, Zaheer, additional, Misseri, Rosalia, additional, DeFoor, W. Robert, additional, Kaefer, Martin, additional, Reddy, Pramod, additional, Rink, Richard C., additional, Minevich, Eugene, additional, and Cain, Mark P., additional
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- 2019
- Full Text
- View/download PDF
399. Validation and Preliminary Results of the Parental Assessment of Children's External Genitalia Scale for Females (PACE-F) for Girls With Congenital Adrenal Hyperplasia
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Szymanski, Konrad M., primary, Whittam, Benjamin, additional, Monahan, Patrick O., additional, Kaefer, Martin, additional, Frady, Heather, additional, Cain, Mark P., additional, and Rink, Richard C., additional
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- 2019
- Full Text
- View/download PDF
400. Human Guanylate Kinase
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Sabo, T.M., primary, Khan, N., additional, Ban, D., additional, Trigo-Mourino, P., additional, Carneiro, M.G., additional, Trent, J.O., additional, Konrad, M., additional, and Lee, D., additional
- Published
- 2019
- Full Text
- View/download PDF
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