201. IκBζ: A key protein in the pathogenesis of psoriasis.
- Author
-
Johansen C
- Subjects
- Adaptor Proteins, Signal Transducing, Animals, Animals, Genetically Modified, Cytokines metabolism, Disease Models, Animal, Humans, I-kappa B Proteins deficiency, Inflammation, Interleukin-17 metabolism, Keratinocytes metabolism, Mice, Nuclear Proteins deficiency, Signal Transduction, I-kappa B Proteins genetics, I-kappa B Proteins metabolism, Nuclear Proteins genetics, Nuclear Proteins metabolism, Psoriasis immunology, Psoriasis physiopathology
- Abstract
Psoriasis is an immune-mediated chronic inflammatory skin disease with a complex etiology. The proinflammatory cytokine IL-17A is known to play key role in the pathogenesis of psoriasis, and recently anti-IL-17A antibodies have been approved for psoriasis treatment. Here, we discuss our recent findings demonstrating that IκBζ, a transcriptional co-activator, plays a crucial role in the development of psoriasis by mediating IL-17A-driven effects. These findings have significant implications as they uncover a novel crucial regulatory mechanism involved in psoriasis development, and identify IκBζ as a possible future target in the treatment of psoriasis and other IL-17A-driven diseases., (Copyright © 2015 Elsevier Ltd. All rights reserved.)
- Published
- 2016
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