351. Serum YKL40: A novel potential link between inflammation and dyslipidemia in acne vulgaris
- Author
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Amany Ibrahim Mustafa, Ola S El-Shimi, Adel A Ebrahim, and Mai Abdallah Fathy
- Subjects
musculoskeletal diseases ,Male ,medicine.medical_specialty ,Adolescent ,Inflammation ,Dermatology ,Significant negative correlation ,Gastroenterology ,Pathogenesis ,030207 dermatology & venereal diseases ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Internal medicine ,Acne Vulgaris ,medicine ,Humans ,Chitinase-3-Like Protein 1 ,Acne ,Triglycerides ,Dyslipidemias ,medicine.diagnostic_test ,business.industry ,Matched control ,Cholesterol, HDL ,Cholesterol, LDL ,medicine.disease ,030220 oncology & carcinogenesis ,Case-Control Studies ,Lipidomics ,Female ,medicine.symptom ,Lipid profile ,business ,Dyslipidemia - Abstract
BACKGROUND Acne vulgaris (AV) is an inflammatory skin disorder that may be associated with metabolic disorders. The relation between lipid profile in acne is not widely investigated. Chitinase-3-like protein 1 (YKL-40) has been found to be implicated in different inflammatory conditions. AIMS We aimed at investigating the role YKL-40 in acne pathogenesis and associated dyslipidemia in acne patients. PATIENTS/METHODS This study included 50 acne vulgaris patients and 30 matched control subjects. Serum YKL-40 in addition to lipid profile were assessed in all studied subjects. RESULTS Serum YKL-40 level was significantly elevated in acne patients than healthy controls (P
- Published
- 2019