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1,388 results on '"Huo, Ran"'

365. Oocyte competence is maintained by m6A methyltransferase KIAA1429-mediated RNA metabolism during mouse follicular development

Author

Hu, Yue, primary, Ouyang, Zhangyi, additional, Sui, Xuesong, additional, Qi, Meijie, additional, Li, Mingrui, additional, He, Yuanlin, additional, Cao, Yumeng, additional, Cao, Qiqi, additional, Lu, Qianneng, additional, Zhou, Shuai, additional, Liu, Lu, additional, Liu, Li, additional, Shen, Bin, additional, Shu, Wenjie, additional, and Huo, Ran, additional

Published
2020
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366. High Dimensional Mass Cytometry Analysis Reveals Characteristics of the Immunosuppressive Microenvironment in Diffuse Astrocytomas

Author

Fu, Weilun, primary, Wang, Wenjing, additional, Li, Hao, additional, Jiao, Yuming, additional, Weng, Jiancong, additional, Huo, Ran, additional, Yan, Zihan, additional, Wang, Jie, additional, Xu, Hongyuan, additional, Wang, Shuo, additional, Wang, Jiangfei, additional, Chen, Dexi, additional, Cao, Yong, additional, and Zhao, Jizong, additional

Published
2020
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380. Bi-allelic variants in DNAH10 cause asthenoteratozoospermia and male infertility.

Author

Li, Kuokuo, Wang, Guanxiong, Lv, Mingrong, Wang, Jieyu, Gao, Yang, Tang, Fei, Xu, Chuan, Yang, Wen, Yu, Hui, Shao, Zhongmei, Geng, Hao, Tan, Qing, Shen, Qunshan, Tang, Dongdong, Ni, Xiaoqing, Wang, Tianjuan, Song, Bing, Wu, Huan, Huo, Ran, and Zhang, Zhiguo

Subjects
MALE infertility, TRANSMISSION electron microscopy, OLIGOSPERMIA, SCANNING electron microscopy, GENETIC counseling, SPERM motility, INFERTILITY
Abstract

Purpose: Multiple morphological abnormalities in the sperm flagella (MMAF) comprise a severe phenotype of asthenoteratozoospermia with reduced or absent spermatozoa motility. Whereas dozens of candidate pathogenic genes for MMAF have been identified, the genetic cause in a large proportion of patients is unknown. We attempted to identify novel genetic explanations for MMAF. Methods: We performed whole-exome sequencing of patients with MMAF to identify pathogenic variants. The phenotypes of spermatozoa in patients carrying DNAH10 variants were investigated using haematoxylin and eosin staining, scanning electron microscopy, and transmission electron microscopy. The expression and location of DNAH10 and other spermatozoa structure–related proteins were analyzed using immunofluorescence assays. Results: We found one homozygous frameshift DNAH10 variant (NM_207437: c.2514delG:p.L839*) and one compound heterozygous DNAH10 variant (NM_207437: c.10820 T > C:p.M3607T; c.12692C > T:p.T4231I) in two patients with MMAF. These variants were absent or rare in the general population. Haematoxylin and eosin staining and scanning electron microscopy revealed the significant disruption of sperm flagella in the patients. In addition, ultrastructural analysis by transmission electron microscopy showed significant inner dynein arm (IDA) deficiency in sperm flagella. Using immunofluorescence assays, we found a significant reduction in IDA-related proteins including DNAH10 and DNAH1. Conclusions: We identified putative novel pathogenic variants in DNAH10 for MMAF, which might advance the genetic diagnosis and clinical genetic counselling for male infertility. [ABSTRACT FROM AUTHOR]

Published
2022
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382. The Warm Dark Matter Doorframe for Light Dark Matter Direct Detection Experiments

Author

Huo, Ran and Xu, Tao

Subjects
High Energy Physics - Phenomenology, High Energy Physics - Experiment (hep-ex), High Energy Physics - Phenomenology (hep-ph), Cosmology and Nongalactic Astrophysics (astro-ph.CO), FOS: Physical sciences, Astrophysics - Cosmology and Nongalactic Astrophysics, High Energy Physics - Experiment
Abstract

If dark matter has even been in sufficient thermal contact with the visible sector and sufficiently light ($m_\chi\lesssim\mathcal{O}(10)~\text{keV}$), the thermal motion inherited from the visible sector will cause significant free streaming effect which is subject to the structure formation constraint, similar to the benchmark thermal warm dark matter model. Here we identify the interaction responsible for such thermal contact to be the interaction probed by the deep underground dark matter direct detection experiments. With the kinetic decoupling technique on the $m_\chi$ vs. $\sigma$ plot we determine the bound shape in detail, and find that recasting the current Lyman-$\alpha$ bound gives a constraint of $m_\chi\gtrsim73~\text{keV}$, and it gets relaxed to $m_\chi\gtrsim35~\text{keV}$ for a smaller cross section of $\sigma, Comment: 7 pages, 3 figures

Published
2019
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385. The Structure of Dissipative Dark Matter Halos

Author

Huo, Ran, Yu, Hai-Bo, Zhong, Yi-Ming, Huo, Ran, Yu, Hai-Bo, and Zhong, Yi-Ming

Abstract

Dissipative dark matter self-interactions can affect halo evolution and change its structure. We perform a series of controlled N-body simulations to study impacts of the dissipative interactions on halo properties. The interplay between gravitational contraction and collisional dissipation can significantly speed up the onset of gravothermal collapse, resulting in a steep inner density profile. For reasonable choices of model parameters controlling the dissipation, the collapse timescale can be a factor of 10-100 shorter than that predicted in purely elastic self-interacting dark matter. The effect is maximized when energy loss per collision is comparable to characteristic kinetic energy of dark matter particles in the halo. Our simulations provide guidance for testing the dissipative nature of dark matter with astrophysical observations., Comment: 7 pages, 2 figures

Published
2019
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386. Refracting into Ultra Diffuse Galaxy NGC 1052-DF2 by Passing near the Center of NGC 1052

Author

Huo, Ran and Huo, Ran

Abstract

The recent observation of the ultra-diffuse galaxy NGC 1052-DF2 shows a galaxy may lack dark matter. Usually dark matter is much more abundant than stellar in galaxy environment. This dark matter to baryon mass ratio is generally larger than the cosmological ratio of about five, since a significant part of baryon is diffused in the form of intergalactic medium. How to achieve such a low dark matter to baryon mass ratio is a challenge to the standard galaxy formation mechanism. Here we show that such a low ratio can be a natural consequence if the NGC 1052-DF2 had experienced a single passage within a few kpcs to the center of galaxy NGC 1052. The tidal effect of NGC 1052 in the encounter will heat the NGC 1052-DF2 up, stretch the previous dwarf galaxy significantly into its current size. The relative lacking of dark matter in the observed region is a natural consequence of the dark matter extended distribution and relatively less concentration in the corresponding central region before encounter, together with a systematic underestimation of the trace mass estimator method during relaxation after encounter. The observed flat distribution of the ultra-diffuse galaxy can be reproduced. Our results shows no need of introducing any new physical mechanism., Comment: 6 pages, 4 figures

Published
2019
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387. Matter Power Spectrum of Light Freeze-in Dark Matter: With or without Self-Interaction

Author

Huo, Ran and Huo, Ran

Abstract

We study the free-streaming effect in a light freeze-in dark matter model. Naturally in the dark sector one can find dark matter related coupling, and such coupling may induce dark matter self-scattering. In case that such scattering is subdominant, the dark matter partition function is not thermal but determined by the freeze-in process, yet its high momentum side is generally also Boltzmann suppressed. We show that the matter power spectrum is very similar to a warm dark matter one in shape. When matched to the current WDM bound, a $24$~keV freeze-in dark matter is ruled out at $2\sigma$ confidence level. In case that the dark matter self-scattering is strong and decouples at a very late time, by a new numerical calculation we show that the early stage Brownian motion indeed protects the power spectrum against free-streaming suppression. However, such an effect cannot be characterized by a free-streaming length alone; we find that the self-scattering decoupling time is another necessary parameter. The currently interested dark matter self-interaction cross section $\sim\text{cm}^2/\text{g}$ is just marginal for such protection to be effective., Comment: 5 pages, 4 figures. Version published on PLB

Published
2019
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390. Double Lipschitz Stability for Nonlinearly neutral Differential Systems with Multiple Delay

Author

Huo Ran and Wang Xiaoli

Subjects
Nonlinear system, Exponential stability, General Engineering, Applied mathematics, Differential systems, Lipschitz continuity, Stability (probability), Differential inequalities, Mathematics, Exponential function, Variable (mathematics)
Abstract

In this paper, first we proves a class of time-delay differential inequalities. And then, the nonlinear differential systems with time delay are considered and it is obtained that the trivial solution of the nonlinear systems with time delay has uniform stability and uniform exponential Lipschitz asymptotic stability with respect to partial variable.

Published
2020

391. Development of segregation and integration of functional connectomes during the first 1,000 days.

Author

Li, Qiongling, Xia, Mingrui, Zeng, Debin, Xu, Yuehua, Sun, Lianglong, Liang, Xinyuan, Xu, Zhilei, Zhao, Tengda, Liao, Xuhong, Yuan, Huishu, Liu, Ying, Huo, Ran, Li, Shuyu, and He, Yong

Abstract

The first 1,000 days of human life lay the foundation for brain development and later cognitive growth. However, the developmental rules of the functional connectome during this critical period remain unclear. Using high-resolution, longitudinal, task-free functional magnetic resonance imaging data from 930 scans of 665 infants aged 28 postmenstrual weeks to 3 years, we report the early maturational process of connectome segregation and integration. We show the dominant development of local connections alongside a few global connections, the shift of brain hubs from primary regions to high-order association cortices, the developmental divergence of network segregation and integration along the anterior-posterior axis, the prediction of neurocognitive outcomes, and their associations with gene expression signatures of microstructural development and neuronal metabolic pathways. These findings advance our understanding of the principles of connectome remodeling during early life and its neurobiological underpinnings and have implications for studying typical and atypical development. [Display omitted] • Brain hubs shift from primary to association regions during the first 1,000 days of life • Functional segregation and integration develop along an anterior-posterior axis • Neonatal connectomes predict cognitive and language outcomes at 1.5 years of age • Network growth is regulated by genes involved in neurodevelopment and metabolism Li et al. report the maturational principles of network segregation and integration of the functional connectome during the first 1,000 days of human life. They also show the importance of early connectome remodeling for later neurocognitive outcomes and establish the associations with gene expression signatures of neurodevelopment and metabolism. [ABSTRACT FROM AUTHOR]

Published
2024
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392. KeV Scale Frozen-in Self-Interacting Fermionic Dark Matter

Author

An, Haipeng, Huo, Ran, and Liu, Wanqiang

Subjects
High Energy Physics - Phenomenology, High Energy Physics - Phenomenology (hep-ph), Astrophysics of Galaxies (astro-ph.GA), FOS: Physical sciences, Astrophysics::Cosmology and Extragalactic Astrophysics, Astrophysics - Astrophysics of Galaxies
Abstract

We present a model in which the dark matter particle is frozen-in at MeV scale. In this model, the mediator between the standard model sector and the dark sector can automatically provide a self-interaction for dark matter. The interaction strength is naturally to be the in the region in favor of the cluster mass deficit anomaly. Due to the self-scattering, the Lyman-$\alpha$ constraint can be relaxed to $m_D \gtrsim 2 $ keV. In this region the self-interaction and the Fermi pressure both play roles on forming a dark matter core at the center of the dwarf galaxies., Comment: 6 pages, 6 figures

Published
2018
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